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106. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications

Author

Tao, Hongyan, Han, Zhibo, Han, Zhong Chao, and Li, Zongjin

Subjects
Article Subject
Abstract

Mesenchymal stem cells (MSCs) have shown their therapeutic potency for treatment of cardiovascular diseases owing to their low immunogenicity, ease of isolation and expansion, and multipotency. As multipotent progenitors, MSCs have revealed their ability to differentiate into various cell types and could promote endogenous angiogenesis via microenvironmental modulation. Studies on cardiovascular diseases have demonstrated that transplanted MSCs could engraft at the injured sites and differentiate into cardiomyocytes and endothelial cells as well. Accordingly, several clinical trials using MSCs have been performed and revealed that MSCs may improve relevant clinical parameters in patients with vascular diseases. To fully comprehend the characteristics of MSCs, understanding their intrinsic property and associated modulations in tuning their behaviors as well as functions is indispensable for future clinical translation of MSC therapy. This review will focus on recent progresses on endothelial differentiation and potential clinical application of MSCs, with emphasis on therapeutic angiogenesis for treatment of cardiovascular diseases.

Published
2016
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107. Additional file 1: of VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity

Author

Wenjing Du, Li, Xue, Chi, Ying, Fengxia Ma, Zongjin Li, Shaoguang Yang, Baoquan Song, Junjie Cui, Ma, Tao, Juanjuan Li, Jianjian Tian, Zhouxin Yang, Xiaoming Feng, Chen, Fang, Shihong Lu, Liang, Lu, Han, Zhi-Bo, and Han, Zhong-Chao

Subjects
cardiovascular system
Abstract

is Table S1 presenting primers for real-time reverse transcription PCR, Table S2 presenting the description of the human cytokine antibody array (AAH-CYT-G1000), Table S3 presenting the phenotype of three donor-derived CV-MSCs, Table S4 presenting differential angiogenesis cytokines of VCAM-1â CV-MSCs and VCAM-1+CV-MSCs, Fig. S1 showing sVCAM-1 concentration in 48-hour CM of VCAM-1+CV-MSCs and VCAM-1â CV-MSCs measured by ELISA, and Fig. S2 showing the endothelial-like cells derived from VCAM-1+CV-MSCs and VCAM-1â CV-MSCs harvested after in vitro endothelial induction and immunostained by anti-vWF antibodies to evaluate their endothelial differentiation capacities. (PDF 524 kb)

Published
2016
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110. Transplantation of Human Placenta-Derived Mesenchymal Stem Cells Alleviates Critical Limb Ischemia in Diabetic Nude Rats

Author

Liang, Lu, primary, Li, Zongjin, additional, Ma, Tao, additional, Han, Zhibo, additional, Du, Wenjing, additional, Geng, Jie, additional, Jia, Honghong, additional, Zhao, Meng, additional, Wang, Jimin, additional, Zhang, Bingjing, additional, Feng, Jie, additional, Zhao, Lanzhen, additional, Rupin, Alain, additional, Wang, Youwei, additional, and Han, Zhong Chao, additional

Published
2017
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112. Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue Maintain Their Immunosuppressive Properties After Chondrogenic Differentiation: Role of HLA-G

Author

Du, Wen-Jing, primary, Reppel, Loic, additional, Leger, Léonore, additional, Schenowitz, Chantal, additional, Huselstein, Celine, additional, Bensoussan, Danièle, additional, Carosella, Edgardo D., additional, Han, Zhong-Chao, additional, and Rouas-Freiss, Nathalie, additional

Published
2016
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113. VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity

Author

Du, Wenjing, primary, Li, Xue, additional, Chi, Ying, additional, Ma, Fengxia, additional, Li, Zongjin, additional, Yang, Shaoguang, additional, Song, Baoquan, additional, Cui, Junjie, additional, Ma, Tao, additional, Li, Juanjuan, additional, Tian, Jianjian, additional, Yang, Zhouxin, additional, Feng, Xiaoming, additional, Chen, Fang, additional, Lu, Shihong, additional, Liang, Lu, additional, Han, Zhi-Bo, additional, and Han, Zhong-Chao, additional

Published
2016
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114. Safety of Mesenchymal Stem Cells for Clinical Application

Author

Wang, Youwei, Han, Zhi-bo, Song, Yong-ping, and Han, Zhong Chao

Subjects
Article Subject
Abstract

Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.

Published
2012
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116. Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer

Author

Wang, Wei-qiang, primary, Zhao, Dan, additional, Zhou, Yu-shan, additional, Hu, Xiao-yu, additional, Sun, Zhi-na, additional, Yu, Gang, additional, Wu, Wan-tong, additional, Chen, Song, additional, Kuang, Jiu-long, additional, Xu, Guo-gang, additional, Han, Zhong-chao, additional, Wang, Bang-mao, additional, Yang, Jing-xian, additional, and Feng, Xiao-ming, additional

Published
2015
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117. Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Author

Song, Bao-quan, primary, Chi, Ying, additional, Li, Xue, additional, Du, Wen-jing, additional, Han, Zhi-Bo, additional, Tian, Jian-jian, additional, Li, Juan-juan, additional, Chen, Fang, additional, Wu, He-he, additional, Han, Li-xin, additional, Lu, Shi-hong, additional, Zheng, Yi-zhou, additional, and Han, Zhong-chao, additional

Published
2015
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118. Human mesenchymal stem cells possess different biological characteristics but do not change their therapeutic potential when cultured in serum free medium

Author

Wang, Youwei, primary, Wu, Hehe, additional, Yang, Zhouxin, additional, Chi, Ying, additional, Meng, Lei, additional, Mao, Aibin, additional, Yan, Shulin, additional, Hu, Shanshan, additional, Zhang, Jianzhong, additional, Zhang, Yun, additional, Yu, Wenbo, additional, Ma, Yue, additional, Li, Tao, additional, Cheng, Yan, additional, Wang, Yongjuan, additional, Wang, Shanshan, additional, Liu, Jing, additional, Han, Jingwen, additional, Li, Caiyun, additional, Liu, Li, additional, Xu, Jian, additional, Han, Zhi Bo, additional, and Han, Zhong Chao, additional

Published
2014
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119. Reduced Intensity Conditioning, Combined Transplantation of Haploidentical Hematopoietic Stem Cells and Mesenchymal Stem Cells in Patients with Severe Aplastic Anemia

Author

Li, Xiao-Hong, primary, Gao, Chun-Ji, additional, Da, Wan-Ming, additional, Cao, Yong-Bin, additional, Wang, Zhi-Hong, additional, Xu, Li-Xin, additional, Wu, Ya-Mei, additional, Liu, Bei, additional, Liu, Zhou-Yang, additional, Yan, Bei, additional, Li, Song-Wei, additional, Yang, Xue-Liang, additional, Wu, Xiao-Xiong, additional, and Han, Zhong-Chao, additional

Published
2014
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122. CD106 Identifies a Subpopulation of Mesenchymal Stem Cells with Unique Immunomodulatory Properties

Author

Yang, Zhou Xin, primary, Han, Zhi-Bo, additional, Ji, Yue Ru, additional, Wang, You Wei, additional, Liang, Lu, additional, Chi, Ying, additional, Yang, Shao Guang, additional, Li, Li Na, additional, Luo, Wei Feng, additional, Li, Jian Ping, additional, Chen, Dan Dan, additional, Du, Wen Jing, additional, Cao, Xiao Cang, additional, Zhuo, Guang Sheng, additional, Wang, Tao, additional, and Han, Zhong Chao, additional

Published
2013
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132. Intrapulmonary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Attenuates Acute Lung Injury by Expanding CD4+CD25+ Forkhead Boxp3 (FOXP3) + Regulatory T Cells and Balancing Anti- and Pro-inflammatory Factors

Author

Sun, Jun, primary, Han, Zhi-Bo, additional, Liao, Wenbin, additional, Yang, Shao Guang, additional, Yang, ZhouXin, additional, Yu, JingXia, additional, Meng, Lei, additional, Wu, Rong, additional, and Han, Zhong Chao, additional

Published
2011
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142. Therapeutic Benefit of Human Umbilical Cord Derived Mesenchymal Stromal Cells in Intracerebral Hemorrhage Rat: Implications of Anti-inflammation and Angiogenesis

Author

Liao, Wenbin, primary, Zhong, Jian, additional, Yu, Jingxia, additional, Xie, Jiang, additional, Liu, Yongjun, additional, Du, Lei, additional, Yang, Shaoguang, additional, Liu, Pengxia, additional, Xu, Jie, additional, Wang, Jiming, additional, Han, Zhibo, additional, and Han, Zhong Chao, additional

Published
2009
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143. Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: Implication in the migration

Author

Li, Guo, primary, Zhang, Xiao‐ai, additional, Wang, Hua, additional, Wang, Xin, additional, Meng, Chun‐ling, additional, Chan, Chu‐yan, additional, Yew, David Tai Wai, additional, Tsang, Kam Sze, additional, Li, Karen, additional, Tsai, Sau‐na, additional, Ngai, Sai‐ming, additional, Han, Zhong Chao, additional, Lin, Marie Chia‐mi, additional, He, Ming‐liang, additional, and Kung, Hsiang‐fu, additional

Published
2008
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