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937 results on '"Hall, David H."'

102. Conserved role for Ataxin‐2 in mediating endoplasmic reticulum dynamics

Author

del Castillo, Urko, primary, Gnazzo, Megan M., additional, Sorensen Turpin, Christopher G., additional, Nguyen, Ken C. Q., additional, Semaya, Emily, additional, Lam, Yuwan, additional, Cruz, Matthew A., additional, Bembenek, Joshua N., additional, Hall, David H., additional, Riggs, Blake, additional, Gelfand, Vladimir I., additional, and Skop, Ahna R., additional

Published
2019
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103. The Marginal Cells of theCaenorhabditis elegansPharynx Scavenge Cholesterol and Other Hydrophobic Small Molecules

Author

Kamal, Muntasir, primary, Moshiri, Houtan, additional, Magomedova, Lilia, additional, Han, Duhyun, additional, Nguyen, Ken CQ, additional, Yeo, May, additional, Knox, Jess, additional, Bagg, Rachel, additional, Won, Amy M., additional, Szlapa, Karolina, additional, Yip, Christopher, additional, Cummins, Carolyn L., additional, Hall, David H., additional, and Roy, Peter J., additional

Published
2019
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107. Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors

Author

Ramirez-Suarez, Nelson J., primary, Belalcazar, Helen M., additional, Salazar, Christopher J., additional, Beyaz, Burcu, additional, Raja, Benjamin, additional, Nguyen, Ken C.Q., additional, Celestrin, Kevin, additional, Fredens, Julius, additional, Færgeman, Nils J., additional, Hall, David H., additional, and Bülow, Hannes E., additional

Published
2019
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110. The connectome of the Caenorhabditis elegans pharynx.

Author

Cook, Steven J., Crouse, Charles M., Yemini, Eviatar, Hall, David H., Emmons, Scott W., and Hobert, Oliver

Abstract

Detailed anatomical maps of individual organs and entire animals have served as invaluable entry points for ensuing dissection of their evolution, development, and function. The pharynx of the nematode Caenorhabditis elegans is a simple neuromuscular organ with a self‐contained, autonomously acting nervous system, composed of 20 neurons that fall into 14 anatomically distinct types. Using serial electron micrograph (EM) reconstruction, we re‐evaluate here the connectome of the pharyngeal nervous system, providing a novel and more detailed view of its structure and predicted function. Contrasting the previous classification of pharyngeal neurons into distinct inter‐ and motor neuron classes, we provide evidence that most pharyngeal neurons are also likely sensory neurons and most, if not all, pharyngeal neurons also classify as motor neurons. Together with the extensive cross‐connectivity among pharyngeal neurons, which is more widespread than previously realized, the sensory‐motor characteristics of most neurons define a shallow network architecture of the pharyngeal connectome. Network analysis reveals that the patterns of neuronal connections are organized into putative computational modules that reflect the known functional domains of the pharynx. Compared with the somatic nervous system, pharyngeal neurons both physically associate with a larger fraction of their neighbors and create synapses with a greater proportion of their neighbors. We speculate that the overall architecture of the pharyngeal nervous system may be reminiscent of the architecture of ancestral, primitive nervous systems. [ABSTRACT FROM AUTHOR]

Published
2020
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111. Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans.

Author

Chaogu Zheng, Atlas, Emily, Lee, Ho Ming Terence, Jao, Susan Laura Javier, Nguyen, Ken C. Q., Hall, David H., and Chalfie, Martin

Subjects
MOLECULAR chaperones, CAENORHABDITIS elegans, NEURONAL differentiation, GABAERGIC neurons, CELL differentiation, MOTOR neurons, MICROTUBULES
Abstract

Molecular chaperones often work collaborativelywith the ubiquitylationproteasome system (UPS) to facilitate the degradation of misfolded proteins, which typically safeguards cellular differentiation and protects cells from stress. In this study, however, we report that the Hsp70/Hsp90 chaperone machinery and an F-box protein, MEC-15, have opposing effects on neuronal differentiation, and that the chaperones negatively regulate neuronal morphogenesis and functions. Using the touch receptor neurons (TRNs) of Caenorhabditis elegans, we find that mec-15(-) mutants display defects in microtubule formation, neurite growth, synaptic development and neuronal functions, and that these defects can be rescued by the loss of Hsp70/Hsp90 chaperones and co-chaperones. MEC-15 probably functions in aSkp-,Cullin- and F-boxcontaining complex to degrade DLK-1, which is an Hsp90 client protein stabilized by the chaperones. The abundance of DLK-1, and likely other Hsp90 substrates, is fine-tuned by the antagonism between MEC-15 and the chaperones; this antagonism regulates TRN development, as well as synaptic functions of GABAergic motor neurons. Therefore, a balance between the UPS and the chaperones tightly controls neuronal differentiation. [ABSTRACT FROM AUTHOR]

Published
2020
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115. Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos

Author

Mutlu, Beste, primary, Chen, Huei-Mei, additional, Moresco, James J., additional, Orelo, Barbara D., additional, Yang, Bing, additional, Gaspar, John M., additional, Keppler-Ross, Sabine, additional, Yates, John R., additional, Hall, David H., additional, Maine, Eleanor M., additional, and Mango, Susan E., additional

Published
2018
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119. Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation inC. elegansembryos

Author

Mutlu, Beste, primary, Chen, Huei-Mei, additional, Moresco, James J., additional, Orelo, Barbara D., additional, Yang, Bing, additional, Gaspar, John M., additional, Keppler-Ross, Sabine, additional, Yates, John R., additional, Hall, David H., additional, Maine, Eleanor M., additional, and Mango, Susan E., additional

Published
2018
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123. A direct glia-to-neuron natural transdifferentiation ensures nimble sensory-motor coordination of male mating behaviour

Author

Molina-García, Laura, primary, Cook, Steven J., additional, Kim, Byunghyuk, additional, Bonnington, Rachel, additional, Sammut, Michele, additional, O’Shea, Jack, additional, Elliott, David J., additional, Hall, David H., additional, Emmons, Scott W., additional, Barrios, Arantza, additional, and Poole, Richard J., additional

Published
2018
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128. Cell invasion and matricide during Photorhabdus luminescens transmission by Heterorhabditis bacteriophora nematodes

Author

Ciche, Todd A., Kwi-suk Kim, Kaufmann-Daszczuk, Bettina, Nguyen, Ken C.Q., and Hall, David H.

Subjects
Bioluminescence -- Analysis, Host-bacteria relationships -- Research, Nematoda -- Environmental aspects, Biological sciences
Abstract

A study was conducted to examine the mutualistic host-bacterium interactions with another rhabditid nematode where transmission of Photorhabdus luminescens is necessary for the insect-pathogenic lifestyle of the two organisms. The results showed that Photorhabdus symbionts are maternally transmitted by an elaborate infectious process involving multiple selective steps in order to attain symbiont-specific transmission.

Published
2008

133. Cover Image, Volume 74, Issue 11

Author

Qadota, Hiroshi, primary, Matsunaga, Yohei, additional, Nguyen, Ken C.Q., additional, Mattheyses, Alexa, additional, Hall, David H., additional, and Benian, Guy M., additional

Published
2017
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145. Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans

Author

Grussendorf, Kelly A, primary, Trezza, Christopher J, additional, Salem, Alexander T, additional, Al-Hashimi, Hikmat, additional, Mattingly, Brendan C, additional, Kampmeyer, Drew E, additional, Khan, Liakot A, additional, Hall, David H, additional, Göbel, Verena, additional, Ackley, Brian D, additional, and Buechner, Matthew, additional

Published
2016
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149. A cellular and regulatory map of the cholinergic nervous system of C. elegans

Author

Howard Hughes Medical Institute, National Institute of Neurological Disorders and Stroke (US), Pereira, Laura, Kratsios, Paschalis, Serrano-Saiz, Esther, Sheftel, Hila, Mayo, Avi E., Hall, David H., White, John G., LeBoeuf, Brigitte, García, L Rene, Alon, Uri, Hobert, Oliver, Howard Hughes Medical Institute, National Institute of Neurological Disorders and Stroke (US), Pereira, Laura, Kratsios, Paschalis, Serrano-Saiz, Esther, Sheftel, Hila, Mayo, Avi E., Hall, David H., White, John G., LeBoeuf, Brigitte, García, L Rene, Alon, Uri, and Hobert, Oliver

Abstract

Nervous system maps are of critical importance for understanding how nervous systems develop and function. We systematically map here all cholinergic neuron types in the male and hermaphrodite C. elegans nervous system. We find that acetylcholine (ACh) is the most broadly used neurotransmitter and we analyze its usage relative to other neurotransmitters within the context of the entire connectome and within specific network motifs embedded in the connectome. We reveal several dynamic aspects of cholinergic neurotransmitter identity, including a sexually dimorphic glutamatergic to cholinergic neurotransmitter switch in a sex-shared interneuron. An expression pattern analysis of ACh-gated anion channels furthermore suggests that ACh may also operate very broadly as an inhibitory neurotransmitter. As a first application of this comprehensive neurotransmitter map, we identify transcriptional regulatory mechanisms that control cholinergic neurotransmitter identity and cholinergic circuit assembly.

Published
2015

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