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739 results on '"Hakala, M."'

104. Pathogenetic mechanism and prevalence of the stable atlantoaxial subluxation in rheumatoid arthritis

Author

Markku Kauppi, Sakaguchi M, Yt, Konttinen, HämäläinenM, and Hakala M

Subjects
Arthritis, Rheumatoid, Joint Instability, Radiography, Atlanto-Axial Joint, Cervical Vertebrae, Joint Dislocations, Prevalence, Humans
Abstract

To study the pathogenetic mechanisms responsible for and prevalence of stable atlantoaxial subluxation (AAS).Lateral view cervical spine radiographs during flexion and extension were studied in 262 patients with rheumatoid arthritis (RA).AAS was found in 130 patients, 42 (32%) of whom had a stable deformity; in a population based subseries, stable AAS was seen in 16% of the patients with ASS. Atlantoaxial impaction (AAI) was diagnosed in 98 cases and in 37 (88%) of the 42 patients with stable AAS.The main cause of the spontaneous stabilization and occasional ankylosis of the atlantoaxial area is the development of erosions and collapse in the lateral facet joints leading to AAI.

Published
1996

106. Measurement of Two Solvation Regimes in Water-Ethanol Mixtures Using X-Ray Compton Scattering

Author

Juurinen, I., primary, Nakahara, K., additional, Ando, N., additional, Nishiumi, T., additional, Seta, H., additional, Yoshida, N., additional, Morinaga, T., additional, Itou, M., additional, Ninomiya, T., additional, Sakurai, Y., additional, Salonen, E., additional, Nordlund, K., additional, Hämäläinen, K., additional, and Hakala, M., additional

Published
2011
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107. Reexamining the Lyman-Birge-Hopfield band of N2

Author

Bradley, J. A., primary, Sakko, A., additional, Seidler, G. T., additional, Rubio, A., additional, Hakala, M., additional, Hämäläinen, K., additional, Cooper, G., additional, Hitchcock, A. P., additional, Schlimmer, K., additional, and Nagle, K. P., additional

Published
2011
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114. Dynamic Response

Author

Pegg, N.G., Cervetto, D., Das, P.K., Frohling, W., Hakala, M., Loseth, R., Senjanović, Ivo, Sielski, R.A., Sumi, Y., Waeghter, J., and Wang, W.H.

Subjects
Dynamic Response
Abstract

Dynamic Response

Published
1994

130. Patients with rheumatoid arthritis have better functional and working ability but poorer general health and higher comorbidity rates today than in the late 1990s.

Author

Uutela, T, Kautiainen, H, Järvenpää, S, Salomaa, S, Hakala, M, and Häkkinen, A

Abstract

Objectives: Better treatment strategies and therapeutic options have changed the treatment of rheumatoid arthritis (RA) during the past decade. Our objective was to examine clinical and patient-reported outcomes in patients with RA treated in 1998–99 and 2011–12. Method: The cross-sectional observational study included 303 consecutive outpatients (n = 103 in 1998–99 and n = 200 in 2011–12) from the same outpatient clinic. Patient questionnaires included patients’ sociodemographics, the Health Assessment Questionnaire (HAQ) for functional ability, the Nottingham Health Profile (NHP) for health-related quality of life (HRQoL), self-reported general health (GH), and operations performed due to RA. A clinical examination was conducted for all patients. Comorbidities according to the Charlson Comorbidity Index (CCI), anti-rheumatic drugs and medications were recorded and the HAQ and NHP dimensions calculated. The results from these two patient cohorts were compared. Results: The cohorts were comparable with regard to age, sex, and RA duration while the patients in the 2011–12 cohort were less often seropositive for rheumatoid factor (RF), had a better socioeconomic situation, better functional and working ability, and a decreased rate of RA surgery. The patients in 2011–12 had higher comorbidities and poorer GH while the HRQoL dimensions did not differ between the cohorts except for better mobility in 2011–12. Methotrexate (MTX) and combinations of conventional anti-rheumatic drugs were more frequently used in 2011–12. Biologicals were used only in 2011–12. Conclusions: According to our results, more active anti-rheumatic therapy coincides with better RA-related outcomes. However, the result was the opposite with regard to overall health and comorbidities. Is this a new challenge in the treatment RA? [ABSTRACT FROM AUTHOR]

Published
2015
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131. Quasi-Static Load Effects

Author

Ziliotto, F., Andersson, L., Ebert, J., Hakala, M., Hong, D.P., Isnard, J.L., Ivanov, L.D., Pegg, N.G., Sakato, T., Senjanović, Ivo, Wang, W.H., and Xirouchakis, P.C.

Subjects
Quasi-Static Load Effects
Abstract

Quasi-Static Load Effects

Published
1991

137. Electronic stucture of methane hydrate studied by Compton scattering

Author

Sternemann, C., primary, Huotari, S., additional, Hakala, M., additional, Paulus, M., additional, Volmer, M., additional, Gutt, C., additional, Buslaps, T., additional, Hiraoka, N., additional, Klug, D. D., additional, Hämäläinen, K., additional, Tolan, M., additional, and Tse, J. S., additional

Published
2006
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146. Identification of COL2A1 gene mutations in patients with chondrodysplasias and familial osteoarthritis.

Author

UCL - SSS/DDUV - Institut de Duve, Ritvaniemi, P, Körkkö, J, Bonaventure, J, Vikkula, Miikka, Hyland, J, Paassilta, P, Kaitila, I, Kääriäinen, H, Sokolov, B P, Hakala, M, UCL - SSS/DDUV - Institut de Duve, Ritvaniemi, P, Körkkö, J, Bonaventure, J, Vikkula, Miikka, Hyland, J, Paassilta, P, Kaitila, I, Kääriäinen, H, Sokolov, B P, and Hakala, M

Abstract

Using the procedure developed for analysis of the COL2A1 gene, mutations were detected in > 20% of patients with chondrodysplasias and up to 2% of patients with early-onset familial OA. However, these percentages are only minimal estimates because all possible mutations in the gene cannot be detected with this procedure.

Published
1995

150. High frequency of reactive arthritis in adults after Yersinia pseudotuberculosis O:1 outbreak caused by contaminated grated carrots.

Author

Vasala, M., Hallanvuo, S., Ruuska, P., Suokas, R., Siitonen, A., and Hakala, M.

Abstract

Objective We describe the epidemiological and microbiological process in the clearing of a foodborne outbreak of O:1 linked to Yersinia pseudotuberculosis raw carrots and frequency of the associated reactive extra-gastrointestinal manifestations. Methods The patient samples were investigated by routine culture or antibody testing methods. The real-time bacterial PCR was used to detect Y pseudotuberculosis in samples from the grated carrots and in those taken from the carrot storage. Genotype of bacterial isolates was determined by pulsed-field gel electrophoresis. For case identification, we retrospectively looked over the laboratory les of the central hospital focusing on the time period of the outbreak. Results Altogether 49 case patients were identified. Y pseudotuberculosis was detected by real-time PCR analysis in samples taken from grated carrots and from the carrot distributor. Bacterial isolates originating from the farm environment showed identical serotype (O:1) and genotype (S12) with the patients' isolates. Among 37 adults, reactive arthritis (ReA) was found in 8 (22%) and three adults had probable ReA. Six (67%) out of nine human leucocyte antigen (HLA) typed patients with ReA were HLA-B27 positive. Erythema nodosum was found in 42% of the 12 children, whereas none of them had definite ReA. Conclusions In this outbreak, Y pseudotuberculosis was for the first time detected in both patient and food samples. ReA was more common than earlier reported in the outbreaks associated with this pathogen; the reason may be that the previous outbreaks have occurred among children. HLA-B27 frequency was higher than usually reported in single-source outbreaks of ReA. [ABSTRACT FROM AUTHOR]

Published
2014
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