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294 results on '"Hajime Yano"'

101. Data screening and reduction in interplanetary dust measurement by IKAROS-ALADDIN

Author: Hajime Yano, Chisato Okamoto, Nobuhiro Moriyama, Makoto Tanaka, Takayuki Hirai, Masayuki Fujii, and Sunao Hasegawa
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Meteorology, Data screening, Aerospace Engineering, Astrophysics, 01 natural sciences, Interplanetary dust cloud, 0103 physical sciences, Interplanetary dust, Calibration, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Physics, Range (particle radiation), Data reduction, Dynamic range, PVDF, Astronomy and Astrophysics, Solar sail, In-situ dust detector, Geophysics, Amplitude, Space and Planetary Science, General Earth and Planetary Sciences, Particle
Abstract: Accepted: 2016-12-17, 資料番号: SA1160351000
Published: 2017

102. Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu

Author: Maximilian Hamm, Nicole Schmitz, Shogo Tachibana, Matthias Grott, Alessandro Maturilli, Ivanka Pelivan, Kazunori Ogawa, Takehiko Arai, Frank Trauthan, Patrick Michel, Marco Delbo, Axel Hagermann, Jörn Helbert, Satoshi Tanaka, Nils Müller, Wladimir Neumann, Naoya Sakatani, Tra-Mi Ho, Stefano Mottola, K-D Matz, Jörg Knollenberg, Alexander Koncz, Stefan Schröder, Jens Biele, Christian Krause, Ralf Jaumann, Jean-Baptiste Vincent, Line Drube, Katharina A. Otto, Hajime Yano, Aurelie Moussi-Soffys, Markus Schlotterer, Hiroki Senshu, C. Pilorget, Martin Knapmeyer, Tatsuaki Okada, Ekkehard Kührt, German Aerospace Center (DLR), DLR Institute of Planetary Research, Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Deutsches Zentrum für Luft- und Raumfahrt (DLR), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), The Open University [Milton Keynes] (OU), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Potsdam, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and Publica
Subjects: Solar System, 010504 meteorology & atmospheric sciences, Infrared, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Mineralogy, 01 natural sciences, Thermal conductivity, 0103 physical sciences, Ultimate tensile strength, Ryugu, Porosity, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Asteroiden, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Institut für Mathematik, Astronomy and Astrophysics, Regolith, Meteorite, Asteroid, [SDU]Sciences of the Universe [physics], ddc:520, Geology, Thermiscche Trägheit, Hayabusa2
Abstract: 著者人数: 37名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 岡田, 達明; 坂谷, 尚哉; 田中, 智; 矢野, 創), Number of authors: 37 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Okada, Tatsuaki; Sakatani, Naoya; Tanaka, Satoshi; Yano, Hajime）, Accepted: 2019-06-04, 資料番号: SA1190164000
Published: 2019

103. Highly porous nature of a primitive asteroid revealed by thermal imaging

Author: Masanao Abe, Takahiro Iwata, Jens Biele, Kazunori Ogawa, Moe Matsuoka, Yuto Takei, Axel Hagermann, Kent Yoshikawa, Yuichi Tsuda, Takeshi Imamura, Eri Tatsumi, Sei-ichiro Watanabe, Masahiko Arakawa, Kohei Kitazato, Koji Wada, Tomohiro Yamaguchi, Kentaro Suko, Matthias Grott, Tomokatsu Morota, Masateru Ishiguro, Osamu Mori, Ryudo Tsukizaki, Hirotomo Noda, Satoshi Tanaka, Fuyuto Terui, T. Takahashi, Tomohiko Sekiguchi, Kei Shirai, Shota Kikuchi, Masanobu Ozaki, Rie Honda, Hajime Yano, Satoshi Hosoda, Hirohide Demura, Jun Takita, Thomas G. Müller, Hirotaka Sawada, Noriyuki Namiki, Toru Kouyama, Tatsuaki Okada, Yuya Mimasu, Tatsuhiro Michikami, Masahiko Hayakawa, Seiji Sugita, Atsushi Fujii, Tetsuya Fukuhara, Takanao Saiki, Yasuhiro Yokota, Hitoshi Ikeda, Go Ono, Yuri Shimaki, Takehiko Wada, Makoto Yoshikawa, Hikaru Yabuta, Hiroshi Takeuchi, Takehiko Arai, Tsuneo Matsunaga, Hiroki Senshu, Naru Hirata, Yoshiko Ogawa, Chikatoshi Honda, Jörn Helbert, Marco Delbo, Koji Matsumoto, Naoya Sakatani, Naoko Ogawa, Yoshiaki Ishihara, Naoyuki Hirata, Rina Noguchi, Takanobu Shimada, Shogo Tachibana, Chikako Hirose, Maximilian Hamm, Sunao Hasegawa, Manabu Yamada, Yukio Yamamoto, Makoto Taguchi, Satoru Nakazawa, Akira Miura, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Multidisciplinary, 010504 meteorology & atmospheric sciences, [PHYS.ASTR.EP]Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Philosophy, Ryuku, Hayabusa, 01 natural sciences, Regolith, 13. Climate action, 0103 physical sciences, Highly porous, Thermisches Infrarot, 010303 astronomy & astrophysics, Humanities, 0105 earth and related environmental sciences, Asteroiden
Abstract: International audience; Carbonaceous (C-type) asteroids1 are relics of the early Solar System that have preserved primitive materials since their formation approximately 4.6 billion years ago. They are probably analogues of carbonaceous chondrites2,3 and are essential for understanding planetary formation processes. However, their physical properties remain poorly known because carbonaceous chondrite meteoroids tend not to survive entry to Earth’s atmosphere. Here we report on global one-rotation thermographic images of the C-type asteroid 162173 Ryugu, taken by the thermal infrared imager (TIR)4 onboard the spacecraft Hayabusa25, indicating that the asteroid’s boulders and their surroundings have similar temperatures, with a derived thermal inertia of about 300 J m−2 s−0.5 K−1 (300 tiu). Contrary to predictions that the surface consists of regolith and dense boulders, this low thermal inertia suggests that the boulders are more porous than typical carbonaceous chondrites6 and that their surroundings are covered with porous fragments more than 10 centimetres in diameter. Close-up thermal images confirm the presence of such porous fragments and the flat diurnal temperature profiles suggest a strong surface roughness effect7,8. We also observed in the close-up thermal images boulders that are colder during the day, with thermal inertia exceeding 600 tiu, corresponding to dense boulders similar to typical carbonaceous chondrites6. These results constrain the formation history of Ryugu: the asteroid must be a rubble pile formed from impact fragments of a parent body with microporosity9 of approximately 30 to 50 per cent that experienced a low degree of consolidation. The dense boulders might have originated from the consolidated innermost region or they may have an exogenic origin. This high-porosity asteroid may link cosmic fluffy dust to dense celestial bodies1
Published: 2019

104. The International Planetary Protection Handbook

Author: Mark A. Sephton, Alissa Haddaji, Patricia Cabezas, Gerhard Kminek, Petra Rettberg, Hajime Yano, Diana Beatriz Margheritis, John Robert Brucato, J. Andy Spry, Susan McKenna-Lawlor, Nicolas Walter, Elke Rabbow, Jean-Louis Fellous, and Commission of the European Communities
Subjects: Solar System, Engineering, 010504 meteorology & atmospheric sciences, Planetary protection, business.industry, Aerospace Engineering, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Icy moon, 01 natural sciences, GeneralLiterature_MISCELLANEOUS, Strahlenbiologie, Engineering management, 13. Climate action, Space and Planetary Science, Industry sector, 0103 physical sciences, Planetary Protection of Outer Solar System (PPOSS), business, Good practice, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract: The Planetary Protection of Outer Solar System (PPOSS) project tackled the science, technology and policy-making components related to biological and organic contamination of outer solar system bodies, in particular icy moons. This intensive three-year program has provided an international platform and forum where science, industry and policy actors met to nurture and catalyze discussions, exchange of knowledge and produce policy recommendations on the matter of planetary protection. The main objectives of the PPOSS project are to: Describe the state-of-the-art and good practice for implementing planetary protection requirements, and identify good practices and lessons to be learnt. Identify scientific challenges, requirements and knowledge gaps related to planetary protection of outer solar system bodies, including small solar system bodies. Develop a European engineering roadmap for the industry sector. Review the international outer solar system planetary protection regulation structure and categorization and suggest improvements, and, Facilitate the dissemination of knowledge related to planetary protection. The PPOSS project gathers seven European partner organizations, one international partner and one international observer.
Published: 2019

105. Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma

Author: Afsana Islam, Hana Yoshimitsu, Teppei Kaminota, Yui Kirino, Junya Tanaka, Hajime Yano, Naohito Hato, Masahiro Okada, Tohru Ugumori, Souhei Mitani, Reina Tanimoto, Yosuke Mizuno, and Tomoyoshi Sanada
Subjects: 0301 basic medicine, Enzyme-Linked Immunosorbent Assay, Lysyl oxidase, Exosomes, Exosome, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Biomarkers, Tumor, Humans, Medicine, RNA, Neoplasm, Cell Proliferation, LOXL2, Squamous Cell Carcinoma of Head and Neck, business.industry, medicine.disease, Immunohistochemistry, Head and neck squamous-cell carcinoma, Gene Expression Regulation, Neoplastic, stomatognathic diseases, 030104 developmental biology, Otorhinolaryngology, Head and Neck Neoplasms, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Biomarker (medicine), Amino Acid Oxidoreductases, business
Abstract: Objectives The secretory enzyme lysyl oxidase like 2 (LOXL2) is speculated to contribute to tumor progression through its functions in the remodeling of extracellular matrix and epithelial-mesenchymal transition. We previously identified elevated expression of LOXL2 in metastatic human head and neck squamous cell carcinoma (HNSCC) cells in a mouse lymph node metastases model. Here we performed a case series study examining LOXL2 expression levels in human serum from HNSCC patients to evaluate whether LOXL2 is worth evaluation in a large cohort study. Methods LOXL2 protein levels in three serum samples from HNSCC patients were assessed by immunoblotting and LOXL2 tissue expression was examined in one human tongue squamous cell carcinoma (SCC) tissue by immunohistochemistry as a representative of HNSCC tissue. Serum samples were further fractionated in exosomes and supernatants by ultracentrifugation, which were then subjected to immunoblot and in vitro LOX activity analyses. Exosomal LOXL2 levels of 36 serum samples from HNSCC patients and seven healthy volunteers were measured using polymer sedimentation exosome preparation followed by ELISA measurement and subjected to statistical analyses. Results Immunoblot analyses revealed that LOXL2 was present in serum exosomal fractions from three HNSCC patients, and we observed approximately threefold higher levels of LOXL2 in HNSCC patients compared with three healthy volunteers. Immunohistochemical LOXL2 staining was detected in HNSCC cells in addition to non-cancerous lipid tissues and some muscles in human tongue HNSCC tissue. Further measurements of exosomal LOXL2 by ELISA showed over ninefold higher mean LOXL2 levels in patients compared with controls. Statistical analysis revealed a correlation between elevated serum exosomal LOXL2 levels and low-grade, but not high-grade, HNSCC. Conclusions Our case series study that elevated serum exosomal LOXL2 levels exhibited a correlation with low-grade HNSCCs. A follow-up large cohort clinical study will be required to determine the potential clinical utility of LOXL2 as a new biomarker and/or therapy target for HNSCCs. Level of evidence 4 Laryngoscope, 130:E327-E334, 2020.
Published: 2019

106. Chloride intracellular channel protein 2 in cancer and non-cancer human tissues: relationship with tight junctions

Author: Kohei Ogawa, Hajime Yano, Afsana Islam, Akihiro Umakoshi, Yutaro Sumida, Yuji Watanabe, Takeharu Kunieda, Rina Uchida, Naoki Abe, Yoshitomo Ueno, Saya Ozaki, Jun Kuwabara, Yasutsugu Takada, Mohammed E. Choudhury, Toshihiro Yorozuya, Junya Tanaka, and Kei Ishimaru
Subjects: 0301 basic medicine, Male, Histology, lymphatic vessel, Non cancer, colorectal cancer, claudin 1, Biochemistry, Chloride, Metastasis, Tight Junctions, 03 medical and health sciences, 0302 clinical medicine, Chloride Channels, medicine, Humans, ZO-1, Aged, Aged, 80 and over, Tight junction, Chemistry, Cancer, Cell Biology, hepatocellular carcinoma, Middle Aged, medicine.disease, Cell biology, 030104 developmental biology, Chloride channel, Female, 030217 neurology & neurosurgery, Intracellular, medicine.drug, Research Paper
Abstract: Chloride intracellular channel protein 2 (CLIC2) belongs to the CLIC family of conserved metazoan proteins. Although CLICs have been identified as chloride channels, they are currently considered multifunctional proteins. CLIC2 is the least studied family member. We investigated CLIC2 expression and localization in human hepatocellular carcinoma, metastatic colorectal cancer in the liver, and colorectal cancer. Significant expression of mRNAs encoding CLIC1, 2, 4, and 5 were found in the human tissues, but only CLIC2 was predominantly expressed in non-cancer tissues surrounding cancer masses. Fibrotic or dysfunctional (aspartate aminotransferase ≥40) non-cancer liver tissues and advanced stage HCC tissues expressed low levels of CLIC2. Endothelial cells lining blood vessels but not lymphatic vessels in non-cancer tissues expressed CLIC2 as well as high levels of the tight junction proteins claudins 1 and 5, occludin, and ZO-1. Most endothelial cells in blood vessels in cancer tissues had very low expressions of CLIC2 and tight junction proteins. CD31+/CD45− endothelial cells isolated from non-cancer tissues expressed mRNAs encoding CLIC2, claudin 1, occludin and ZO-1, while similar cell fractions from cancer tissues had very low expressions of these molecules. Knockdown of CLIC2 expression in human umbilical vein endothelial cells (HUVECs) allowed human cancer cells to transmigrate through a HUVEC monolayer. These results suggest that CLIC2 may be involved in the formation and/or maintenance of tight junctions and that cancer tissue vasculature lacks CLIC2 and tight junctions, which allows the intravasation of cancer cells necessary for hematogenous metastasis.
Published: 2019

107. The geomorphology, color, and thermal properties of Ryugu: Implications for parent-body processes

Author: Axel Hagermann, Yuri Shimaki, Makoto Yoshikawa, Masateru Ishiguro, Osamu Mori, Takehiko Arai, Masahiro Hayakawa, Takahiro Hiroi, Robert Gaskell, Manabu Yamada, Kei Shirai, N. Takaki, Takanao Saiki, Moe Matsuoka, Yuto Takei, Hirotaka Sawada, Naru Hirata, Fuyuto Terui, Yoshiaki Ishihara, Yoshiyuki Tsuda, Seiichi Tazawa, Hiroaki Kamiyoshihara, Ryodo Hemmi, Deborah L. Domingue, Rina Noguchi, Shinsuke Abe, Nicole Schmitz, Masanao Abe, Ralf Jaumann, Satoru Nakazawa, L. Le Corre, Kazuyoshi Asari, Takanobu Shimada, Shogo Tachibana, Yusuke Oki, M. Ozaki, R. Yamada, Katharina A. Otto, Hiroshi Araki, Faith Vilas, S. Oshigami, Toshimichi Otsubo, Patrick Michel, C. Sugimoto, K. Ogawa, Hideaki Kikuchi, Sei-ichiro Watanabe, Hiroki Senshu, Florian Thuillet, Yutaka Suzuki, T. Fukuhara, Sunao Hasegawa, K. Yamamoto, Ronald-Louis Ballouz, Satoshi Tanaka, Naoya Sakatani, Hirohide Demura, Paul A. Abell, Yuya Mimasu, T. G. Müller, Yoshiko Ogawa, Hideaki Miyamoto, Goro Komatsu, Shota Kikuchi, Carolyn M. Ernst, Fumi Yoshida, Olivier S. Barnouin, Eric Palmer, Rie Honda, Tomoki Nakamura, Yasuhiro Yokota, Yuki Takao, Tomohiko Sekiguchi, Kosuke Yoshioka, Shingo Kameda, Satoshi Hosoda, Eri Tatsumi, Kenji Nagata, Hajime Yano, Takahiro Iwata, Stefan Schröder, Yukio Yamamoto, Makoto Taguchi, Tatsuhiro Michikami, Kent Yoshikawa, J. Kimura, H. Suzuki, Seiji Sugita, Noriyuki Namiki, Yuichiro Cho, Go Ono, C. Honda, Hikaru Yabuta, Tomokatsu Morota, Ryudo Tsukizaki, A. Higuchi, Masatoshi Hirabayashi, Masato Okada, T. Takahashi, M. Shizugami, Chikako Hirose, Kazutaka Nishiyama, Takahide Mizuno, Hirotomo Noda, M. A. Barucci, Sho Sasaki, Masaki Fujimoto, Atsushi Fujii, Seiitsu Tsuruta, Tatsuaki Okada, Stefania Soldini, H. Ikeda, Tomohiro Yamaguchi, Michael E. Zolensky, Toru Kouyama, Koji Matsumoto, Naoko Ogawa, Yuichi Iijima, Hiroshi Takeuchi, Institute of Ecology, Tallinn University-Tallinn University, Institute of Space and Astronautical Science (ISAS), Department of Physics, Tokyo, Waseda University, Institute for Research on Earth Evolution [Yokosuka] (IFREE), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Institute of Observational Research for Global Change, Department of Applied Physics, The University of Tokyo, University of Electro-Communications [Tokyo] (UEC), Seoul National University [Seoul] (SNU), Tsukuba Space Center (TKSC), Japan Aerospace Exploration Agency [Tokyo] (JAXA), National Institute of Polar Research [Tokyo] (NiPR), Brown University, Service d'hépato-gastro-entérologie [Hôpital Saint-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Max-Planck-Institut für Quantenoptik (MPQ), Max-Planck-Gesellschaft, College of Industrial Technology, Nihon University, The Open University [Milton Keynes] (OU), Hiroshima University, Electronic Navigation Research Institute (ENRI), Ministry of Land, Infrastructure, Transport and Tourism, Dept Anim & Dairy Sci, University of Gerogia, National Institute of Agro-Environmental Sciences (NIAES), Mitsubishi Research Institute, Inc., Department of Natural History Sciences, Hokkaido University, Planetary Science Institute [Tucson] (PSI), Sol Agro et hydrosystème Spatialisation (SAS), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Max-Planck-Institut für Sonnensystemforschung (MPS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), GEOMA, Université de Vigo, Universidate de Vigo, Plasma Research Center, University of Tsukuba, IHP Microelctronics, Advanced Materials Institute and Department of Chemistry, Fukuoka University, Department of Applied Mathematics and Physics, Graduate school of Mathematics, Kyoto-Kyoyo University, Department of Environmental and Materials Engineering, Nagoya Institute, Graduate School of Science and Engineering, Tokyo Metropolitan University [Tokyo], Institute of Environmental Systems (SUIKO), Kyushu University [Fukuoka], Graduate School of Science and Technology, Keio University, Rikkyo University [Tokyo], Dept. of Electronics Engineering, University of Electro-Communication, Institute for Sustainable Humanosphere (RISH), Kyoto University [Kyoto], Graduate School of Pharmaceutical Sciences, Tohoku, Tohoku University [Sendai], SolarTerrestrial Environment Laboratory, Nagoya University, Department of Geology and Geophysics, Ministry of Land, Infrastructure, Transport and Tourism (MLIT), Hokkaido University [Sapporo, Japan], DLR Institute of Planetary Research, German Aerospace Center (DLR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universidade de Vigo, Department of Advanced Technology and Development, BML, Matoba, Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Department of Physics, University of California [Irvine] (UCI), University of California-University of California, Biomécanique et génie biomédical (BIM), Centre National de la Recherche Scientifique (CNRS), University of Alaska [Fairbanks] (UAF), Information Science Laboratory, Department of Electronics and Electrical Engineering, Faculty of Science and Technology, Keio University, Department of Earth and Planetary Sciences [Kobe], Kobe University, ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), The University of Tokyo (UTokyo), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Asteroiden und Kometen, Physics, Multidisciplinary, 010504 meteorology & atmospheric sciences, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Stereochemistry, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], 01 natural sciences, Article, Planetengeologie, [SDU]Sciences of the Universe [physics], 0103 physical sciences, Ryugu, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: 著者人数: 120名(所属. 宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS): 澤田, 弘崇; 横田, 康弘; 坂谷, 尚哉; 岡田, 達明; 田中, 智; 飯島, 祐一; 早川, 雅彦; 松岡, 萌; R.-L. Ballouz; 嶌生, 有理; 水野, 貴秀; 石原, 吉明; 長谷川, 直; 藤本, 正樹; 吉川, 真; 山本, 幸生; 白井, 慶; R. Noguchi; 尾川, 順子; 照井, 冬人; 菊地, 翔太; 山口, 智宏; 竹内, 央, 三桝, 裕也; 高橋, 忠輝; 竹井, 洋; 藤井, 淳; 中澤, 暁; 細田, 聡史; 森, 治; 嶋田, 貴信; Soldini, Stefania; 岩田, 隆浩; 安部, 正真; 矢野, 創; 月崎, 竜童; 尾崎, 正伸; 西山, 和孝; 佐伯, 孝尚; 渡邊, 誠一郎; 津田, 雄一), Accepted: 2019-03-12, 資料番号: SA1180387000
Published: 2019

108. Ultra-violet imaging of the night-time earth by EUSO-Balloon towards space-based ultra-high energy cosmic ray observations

Author: A. Anzalone, Toshiyuki Nonaka, Javier Licandro, K. Benmessai, B. Beldjilali, E. Kuznetsov, N. Blanc, J. L. Marcos, G. Puehlhofer, T. Djemil, Toshiki Tajima, Giuseppe Giraudo, A. Kedadra, K. S. Caballero, M. Di Martino, M. Ave Pernas, S. Blin-Bondil, G. Cordero, H. Khales, L. Allen, P. Baragatti, A. Marini, Hitoshi Ohmori, Alberto Cellino, Hiroyuki Sagawa, I. Dutan, Yoshiya Kawasaki, T. Napolitano, malek mastafa, B. A. Khrenov, Sebastián Franchini, T. Paul, G. Cotto, C. De Donato, I. Stan, P. Gorodetzky, A. Pagliaro, S. Jeong, J. Watanabe, Piergiorgio Picozza, D. Allard, M. Suzuki, L. López Campano, Soon-Wook Kim, J. Rabanal, G. Osteria, Guillaume Prévôt, O. Larsson, L. R. Wiencke, A. Ebersoldt, Yoshio Arai, Francesca Bisconti, J. Hernández Carretero, Katsuhiko Tsuno, I. Kreykenbohm, D. Kolev, A. Radu, N. Tajima, M. Takeda, Shigehiro Nagataki, A. Guzmán, C. Lachaud, Christer Fuglesang, José Meseguer, A. Menshikov, Osvaldo Catalano, Silvia Ferrarese, R. Greg, J. Mimouni, C. González Alvarado, M. E. Bertaina, Valentina Scotti, M. Bogomilov, N. Mebarki, Y. Martín, C. De Santis, Ken'ichi Nomoto, G. Chiritoi, R. Attallah, N. Tone, K. Martens, Valerie Connaughton, Angel Sanz-Andrés, L. Marcelli, G. Masciantonio, I. S. Zgura, J. Tubbs, Hirohiko M. Shimizu, Austin Cummings, M. Wille, H. Krantz, F. Kajino, A. Jung, Y. Tsunesada, Y. Uchihori, A. La Barbera, H. Lahmar, Daisuke Yonetoku, G. Medina-Tanco, Mohammed Bakiri, Maciej Rybczyński, K. Kudela, J. F. Krizmanic, J. Genci, Konstantin Belov, F.J. Ronga, Yoshimasa Kurihara, C. Moretto, A. Diaz Damian, Jin Yong Lee, H. Schieler, Alfonso Monaco, Antonella Castellina, Mitsuteru Sato, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Z. Polonsky, Humberto Ibarguen Salazar, T. Shirahama, T. Jammer, Santiago Pindado, Junpei Fujimoto, G. Abdellaoui, L. Villaseñor, Y. Hachisu, G. Roudil, H. Tokuno, Pavol Bobik, F. Perfetto, Hajime Yano, O. Martinez, Bruno Spataro, Tokonatsu Yamamoto, S. Kalli, M. Yu. Zotov, John N. Matthews, Katsuaki Asano, Estíbaliz Gascón, B. Harlov, Carlo Vigorito, Roberto Bellotti, K. Mase, R. Nava, B. Pastirčák, J. Watts, E. Bozzo, S. Turriziani, Toshikazu Ebisuzaki, M. A. Mendoza, Pierre Barrillon, S. Briz, Eduardo García-Ortega, M. Sanz Palomino, E. M. Popescu, Barbara Szabelska, W. Painter, James H. Adams, Sergei A. Sharakin, Rossella Caruso, M. Vrabel, P. Prat, Francesco Isgrò, S. Bartocci, M. Traïche, Josef Jochum, Piero Vallania, M. D. Sabau, Z. Sahnoune, J. A. Morales de los Ríos, T. Peter, S. Naitamor, R. Tsenov, Tomás Belenguer, J. C. Sanchez Balanzar, Gustavo Alonso, F. Cafagna, W. Marszał, Satoshi Wada, Toshitaka Kajino, Piotr Orleanski, J.N. Capdevielle, R. Young, D. Campana, F. Lakhdari, T. Ogawa, W. Hidber Cruz, Thomas Schanz, Daisuke Ikeda, E. Joven, Inkyu Park, N. Belkhalfa, Francesca Capel, P. Galeotti, A. Pollini, Pavel Klimov, B. Panico, M. C. Talai, S. Bacholle, A. J. de Castro, M. Putis, M. Haiduc, Lech Wiktor Piotrowski, Susumu Inoue, S. S. Meyer, Francesco Fenu, S. B. Thomas, H. Miyamoto, Livio Conti, Angela V. Olinto, H. Attoui, Ovidiu Vaduvescu, C. Tenzer, T. Sugiyama, J. Błȩcki, Sergio Fernández-González, R. Matev, J. F. Valdés-Galicia, J. Bayer, Claudio Cassardo, Andrea Santangelo, A. Neronov, L. G. Tkachev, Simona Toscano, A. Weindl, A. Zuccaro Marchi, M. C. Maccarone, M. Fouka, S. Mackovjak, S. Yoshida, J. Szabelski, L. Caramete, Jörn Wilms, Takayuki Tomida, Dmitri Semikoz, C. de la Taille, Naoto Sakaki, C. Catalano, G. Vankova, D. Supanitsky, Mark Christl, O. Tibolla, O. A. Saprykin, Yoshitaka Itow, K. Katahira, A. Belov, H. Prieto, A. Caramete, R. Cremonini, Andrés Merino, Hajime Takami, F. López, M. Rezazadeh, S. Selmane, D. Maravilla, S. Biktemerova, Masaki Fukushima, E. G. Judd, Isabel Pérez-Grande, Shinsuke Abe, P. Carlson, F. Sarazin, A. Haungs, S. Piraino, Kenji Shinozaki, Zbigniew Wlodarczyk, H. J. Crawford, Gali Garipov, Marc Weber, R. Weigand Muñoz, A. Kusenko, S. Pliego, M. Martucci, Shoichi Ogio, Y. Karadzhov, M. Flamini, J. Yang, B. Vlcek, Y. Takizawa, Amine Ahriche, L. Placidi, P. L. Biermann, M. D. Rodríguez Frías, M. Kleifges, I. Rusinov, Z. Plebaniak, I. V. Yashin, K. Kawai, Michiyuki Chikawa, Marcos Reyes, Akinori Saito, S. E. Csorna, Johannes Eser, M. Serra, Luis A. Anchordoqui, A. Bruno, Jeong-Sook Kim, I. Kaneko, T. Patzak, Yoshihiko Mizumoto, J. Karczmarczyk, G. Sáez Cano, Fausto Guarino, P. von Ballmoos, M. Ricci, S. Dagoret-Campagne, Yukihiro Takahashi, José Luis Sánchez, Marco Casolino, Claudio Fornaro, Mikhail Panasyuk, Ralph Engel, Takahiro Fujii, M. Mahdi, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. -N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Diaz Damian, A., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernandez-Gonzalez, S., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Genci, J., Giraudo, G., Gonzalez Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernandez Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, J. -S., Kim, S. -W., Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Krizmanic, J. F., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lopez Campano, L., Lopez, F., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszal, W., Martens, K., Martin, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Rios, J. A., Moretto, C., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, Beatrice, Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Perez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonsky, Z., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodriguez Frias, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sanchez, J. L., Santangelo, A., Sanz-Andres, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Munoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Y., Zuccaro Marchi, A., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: lens, air, media_common.quotation_subject, tube, JEM-EUSO, Extensive air shower, Airglow, EUSO-Balloon, Ultra-high energy cosmic ray, 7. Clean energy, 01 natural sciences, detector: fluorescence, Aeronáutica, pixel, 0103 physical sciences, ultraviolet, Ultra-high-energy cosmic ray, cosmic radiation: UHE, backscatter, 010303 astronomy & astrophysics, particle source, Astrophysique, media_common, Physics, COSMIC cancer database, showers: atmosphere, Settore FIS/05, 010308 nuclear & particles physics, background, photon, Astronomy, imaging, Astronomy and Astrophysics, Astronomie, Photon counting, Universe, observatory, Pathfinder, Refracting telescope, trajectory, Trajectory, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], satellite: orbit
Abstract: The JEM-EUSO (Joint Experiment Missions for the Extreme Universe Space Observatory) program aims at developing Ultra-Violet (UV) fluorescence telescopes for efficient detections of Extensive Air Showers (EASs) induced by Ultra-High Energy Cosmic Rays (UHECRs) from satellite orbit. In order to demonstrate key technologies for JEM-EUSO, we constructed the EUSO-Balloon instrument that consists of a ∼1 m 2 refractive telescope with two Fresnel lenses and an array of multi-anode photo-multiplier tubes at the focus. Distinguishing it from the former balloon-borne experiments, EUSO-Balloon has the capabilities of single photon counting with a gate time of 2.3 µs and of imaging with a total of 2304 pixels. As a pathfinder mission, the instrument was launched for an 8 h stratospheric flight on a moonless night in August 2014 over Timmins, Canada. In this work, we analyze the count rates over ∼2.5 h intervals. The measurements are of diffuse light, e.g. of airglow emission, back-scattered from the Earth's atmosphere as well as artificial light sources. Count rates from such diffuse light are a background for EAS detections in future missions and relevant factor for the analysis of EAS events. We also obtain the geographical distribution of the count rates over a ∼780 km 2 area along the balloon trajectory. In developed areas, light sources such as the airport, mines, and factories are clearly identified. This demonstrates the correct location of signals that will be required for the EAS analysis in future missions. Although a precise determination of count rates is relevant for the existing instruments, the absolute intensity of diffuse light is deduced for the limited conditions by assuming spectra models and considering simulations of the instrument response. Based on the study of diffuse light by EUSO-Balloon, we also discuss the implications for coming pathfinders and future space-based UHECR observation missions., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2019

109. Lister hooded rats as a novel animal model of attention-deficit/hyperactivity disorder

Author: Mariko Eguchi, Toshihiro Jogamoto, Madoka Kubo, Hajime Yano, Kazuya Miyanishi, Mohammed E. Choudhury, Nanako Kihara, Masahiro Nagai, Yusuke I. Shimizu, Eiichi Ishii, Ryo Utsunomiya, Arisa Sato, Junya Tanaka, Masahiro Nomoto, and Mitsumasa Fukuda
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, Elevated plus maze, Social Interaction, Prefrontal Cortex, Morris water navigation task, Atomoxetine Hydrochloride, Open field, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Species Specificity, Rats, Inbred SHR, Internal medicine, mental disorders, medicine, Animals, Attention deficit hyperactivity disorder, Attention, Rats, Wistar, Maze Learning, Prefrontal cortex, Radial arm maze, business.industry, Atomoxetine, Rats, Inbred Strains, Cell Biology, medicine.disease, Guanfacine, Rats, Disease Models, Animal, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Attention Deficit Disorder with Hyperactivity, Impulsive Behavior, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: Appropriate animal models are necessary to determine the molecular and cellular mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). This study used a battery of behavioral tests to compare Lister hooded rats (LHRs), an old outbred strain frequently used for autistic epilepsy research, with Wistar rats and spontaneously hypertensive rats (SHRs), a commonly used ADHD model. The open field, elevated plus maze, light/dark box, and drop tests demonstrated that LHRs were the most hyperactive animals and displayed the most inattentive- and impulsive-like behaviors, which are characteristics of ADHD. The radial arm maze, social interaction, and Morris water maze tests showed that LHRs did not display deficits characteristic of autism or intellectual disability. Although LHRs did not show different monoamine contents, the mRNA expression levels of various genes linked to ADHD (Cdh13, Drd5, Foxp2, Maoa, Sema6d, Slc9a9, and St3gal3) and tyrosine hydroxylase protein expression levels were lower in the prefrontal cortex of LHRs compared with that of Wistar rats or SHRs. c-Fos, synapsin I, and tau protein expression levels in the prelimbic region of the medial prefrontal cortex were also increased in LHRs compared with Wistar rats. Atomoxetine and guanfacine, commonly used non-stimulant treatments for ADHD, ameliorated ADHD-like behaviors in LHRs. These results suggest that LHRs can serve as a better ADHD model to develop novel pharmacological interventions.
Published: 2020

110. The Small Carry-on Impactor (SCI) and the Hayabusa2 Impact Experiment

Author: Y. Takagi, Hajime Yano, Masahiko Hayakawa, Takanao Saiki, Koji Wada, Kei Shirai, H. Imamura, Chisato Okamoto, and Masahiko Arakawa
Subjects: Shaped charge, 010504 meteorology & atmospheric sciences, Explosive material, 01 natural sciences, Artificial crater, Astrobiology, Small carry-on impactor, Sample return mission, Impact crater, 0103 physical sciences, Aerospace engineering, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Scientific instrument, Impact experiment, business.industry, Asteroid exploration, Astronomy and Astrophysics, Regolith, Space and Planetary Science, Asteroid, business, Guidance system, Geology, Hayabusa2
Abstract: Accepted: 2016-10-03, 資料番号: SA1160287000
Published: 2016

111. The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia

Author: Naoto Seo, Keisuke Miyamoto, Haruna Takeda, Chisato Kawamoto, Yurika Ishii, Hiromi Higaki, Hisaaki Takahashi, Mohammed E. Choudhury, Afsana Islam, Kazuya Miyanishi, Kana Sugimoto, Hajime Yano, and Junya Tanaka
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Gene Expression, Substantia nigra, Proinflammatory cytokine, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, medicine, Animals, Hypnotics and Sedatives, Rats, Wistar, Oxidopamine, Cells, Cultured, Hydroxydopamine, Dose-Response Relationship, Drug, Microglia, Pars compacta, business.industry, Dopaminergic Neurons, Growth factor, Dopaminergic, Cell Biology, Coculture Techniques, Rats, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Interferon Regulatory Factors, Immunology, Bromisovalum, business, 030217 neurology & neurosurgery, Interferon regulatory factors
Abstract: The low molecular weight organic compound bromovalerylurea (BU) has long been used as a hypnotic/sedative. In the present study, we found that BU suppressed mRNA expression of proinflammatory factors and nitric oxide release in lipopolysaccharide (LPS)-treated rat primary microglial cell cultures. BU prevented neuronal degeneration in LPS-treated neuron-microglia cocultures. The anti-inflammatory effects of BU were as strong as those of a synthetic glucocorticoid, dexamethasone. A rat hemi-Parkinsonian model was prepared by injecting 6-hydroxydopamine into the right striatum. BU was orally administered to these rats for 7 days, which ameliorated the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and alleviated motor deficits. BU suppressed the expression of mRNAs for interferon regulatory factors (IRFs) 1, 7 and 8 in the right (lesioned) ventral midbrain as well as those for proinflammatory mediators. BU increased mRNA expression of various neuroprotective factors, including platelet-derived growth factor and hepatocyte growth factor, but it did not increase expression of alternative activation (M2) markers. In microglial culture, BU suppressed the LPS-induced increase in expression of IRFs 1 and 8, and it reduced LPS-induced phosphorylation of JAK1 and STATs 1 and 3. Knockdown of IRFs 1 and 8 suppressed LPS-induced NO release by microglial cells. These results suggest that suppression of microglial IRF expression by BU prevents neuronal cell death in the injured brain region, where microglial activation occurs. Because many Parkinsonian patients suffer from sleep disorders, BU administration before sleep may effectively ameliorate neurological symptoms and alleviate sleep dysfunction.
Published: 2016

112. Mars Impact Probability Analysis for the Hayabusa-2 NEO Sample Return Mission

Author: Toshihiro Chujo, Makoto Yoshikawa, Yuichi Tsuda, Yukio Shimizu, and Hajime Yano
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Planetary protection, Aerospace Engineering, 01 natural sciences, Asteroid sample return, Astrobiology, Sample return mission, 0103 physical sciences, 010303 astronomy & astrophysics, Analysis method, 0105 earth and related environmental sciences, Mars impact probability, Committee on Space Research, Ion thruster, Spacecraft, business.industry, Astronomy and Astrophysics, Mars Exploration Program, Geophysics, Space and Planetary Science, Trajectory, General Earth and Planetary Sciences, Environmental science, business
Abstract: Accepted: 2015-07-30, 資料番号: SA1150279000
Published: 2016

113. Investigation of the Interplanetary Transfer of Microbes in the Tanpopo Mission at the Exposed Facility of the International Space Station

Author: Hirofumi Hashimoto, Makoto Tabata, Yuko Kawaguchi, Hajime Yano, Shin-ichi Yokobori, Akihiko Yamagishi, and Hideyuki Kawai
Subjects: Bacteria, 010504 meteorology & atmospheric sciences, Altitude, Fungi, Planets, Space Flight, 01 natural sciences, Agricultural and Biological Sciences (miscellaneous), Mini review, Astrobiology, Space and Planetary Science, Abiogenesis, Panspermia, 0103 physical sciences, International Space Station, Environmental science, Interplanetary spaceflight, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Space debris, Space environment
Abstract: Accepted: 2015-11-23, 資料番号: SA1160003000
Published: 2016

114. A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages

Author: Akihiro Umakoshi, Kana Kobayashi, Hajime Yano, Yoshitomo Ueno, Yoshiaki Kumon, Ayano Mise, Junya Tanaka, Yu Funahashi, Yoshiaki Kamei, Takanori Ohnishi, Shirabe Matsumoto, and Yasutsugu Takada
Subjects: 0301 basic medicine, Original article, Cancer Research, Genetic Vectors, Gene Expression, Apoptosis, Biology, lcsh:RC254-282, 03 medical and health sciences, Antigens, CD, Cell Line, Tumor, Glioma, Gene Order, Tumor Microenvironment, medicine, Animals, Humans, Cytotoxic T cell, RNA, Messenger, Cloning, Molecular, Antigen-presenting cell, CD86, Tumor microenvironment, Brain Neoplasms, Macrophages, Liver Neoplasms, Dendritic Cells, Dendritic cell, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Rats, Alternative Splicing, Disease Models, Animal, Phenotype, 030104 developmental biology, Granzyme, Cancer research, biology.protein, Heterografts, Biomarkers, CD8
Abstract: CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L) but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat C6 glioma cell lines that expressed either CD200L or CD200S; the original C6 cell line did not express CD200 molecules. The cell lines showed no significant differences in growth. Upon transplantation into the neonatal Wistar rat forebrain parenchyma, rats transplanted with C6-CD200S cells survived for a significantly longer period than those transplanted with the original C6 and C6-CD200L cells. The C6-CD200S tumors were smaller than the C6-CD200L or C6-original tumors, and many apoptotic cells were found in the tumor cell aggregates. Tumor-associated macrophages (TAMs) in C6-CD200S tumors displayed dendritic cell (DC)-like morphology with multiple processes and CD86 expression. Furthermore, CD3(+), CD4(+) or CD8(+) cells were more frequently found in C6-CD200S tumors, and the expression of DC markers, granzyme, and perforin was increased in C6-CD200S tumors. Isolated TAMs from original C6 tumors were co-cultured with C6-CD200S cells and showed increased expression of DC markers. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8(+) cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. The findings on CD200S action may provide a novel therapeutic modality for the treatment of carcinomas.
Published: 2016

115. Development of mechanical space thermometer for the Tanpopo mission

Author: Akihiko Yamagishi, Shin-ichi Yokobori, Eiichi Imai, Hideyuki Watanabe, Hirofumi Hashimoto, and Hajime Yano
Subjects: Engineering, Development (topology), business.industry, Thermometer, Aerospace engineering, Space (mathematics), business
Published: 2016

116. A Feasible Study of In-Situ Measurements of Light Isotopes and Organic Molecules with High Resolution Mass Spectrometer MULTUM on the OKEANOS Mission.

Author: Motoo ITO, Tatsuaki OKADA, Yoko KEBUKAWA, Jun AOKI, Yosuke KAWAI, Jun MATSUMOTO, Toshihiro CHUJO, Ryosuke NAKAMURA, Hajime YANO, Sho-ichiro YOKOTA, Michisato TOYODA, Hisayoshi YURIMOTO, Motoki WATANABE, Ryota IKEDA, Yuki KUBO, Noel GRAND, Herve COTTIN, Arnaud BUCH, Cyril SZOPA, and Osamu MORI
Subjects: PHOTOMETRY, OUTER space, SOLAR system, SOLAR sails, SOLAR energy, GASKETS
Abstract: The OKEANOS mission utilizing the Solar Power Sail is one of the candidates of the strategic middle-class space exploration to the outer Solar System lead by the JAXA. The mission is planning to be launched in 2030’s, and rendezvous for spectral observations and landing for in-situ measurements of light isotopes and organic molecules to a D or P type Jupitar Trojan asteroid in 2040’s. The flagship instrument on board is a high-resolution mass spectrometry (HRMS) system together with suits of remote-sensing instruments. Through in-depth scientific observations, the OKEANOS mission will provide critical input to the key questions of (1) constraining planet formation/migration theories, and (2) inventory and distribution of volatiles in the Solar System. We have conducted experimental tests of a sample canister sealing by a metal seal knifeedge, sample canister-MULTUM test, gas chromatograph-MULTUM coupling test for organics, and H and N isotopic measurements in the atmospheric air. Current performances are (1) high mass resolution was 30,000 at m/z = 20, (2) sample canister system with a knife-edge metal seal kept 90 % of a released gas in 1 hour for Cu or Au gaskets with/without regolith, (3) error meets the required precision and accuracy for nitrogen isotopic measurement but for hydrogen. These experiment tests need to continue for our scientific proposes on the asteroids. [ABSTRACT FROM AUTHOR]
Published: 2021
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117. Chronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord

Author: Sakiko Kitamura, Naoki Abe, Shinichiro Ochi, Hajime Yano, Keizo Ikemune, Toshihiro Yorozuya, Mohammed E. Choudhury, Tasuku Nishihara, Yuki Nishikawa, Junya Tanaka, Keisuke Sekiya, and Taisuke Hamada
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Myelin, 0302 clinical medicine, Internal medicine, medicine, Animals, Nociception assay, Rats, Wistar, Motor Neurons, Microglia, biology, Macrophages, Cell Biology, Spinal cord, Sciatic Nerve, Myelin basic protein, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Spinal Cord, nervous system, chemistry, Hyperalgesia, Chondroitin sulfate proteoglycan, biology.protein, Neuralgia, Sciatic nerve, medicine.symptom, 030217 neurology & neurosurgery
Abstract: Chronic constriction injury of the sciatic nerve is frequently considered as a cause of chronic neuropathic pain. Marked activation of microglia in the posterior horn (PH) has been well established with regard to this pain. However, microglial activation in the anterior horn (AH) is also strongly induced in this process. Therefore, in this study, we compared the differential activation modes of microglia in the AH and PH of the lumbar cord 7 days after chronic constriction injury of the left sciatic nerve in Wistar rats. Microglia in both the ipsilateral AH and PH demonstrated increased immunoreactivity of the microglial markers Iba1 and CD11b. Moreover, abundant CD68+ phagosomes were observed in the cytoplasm. Microglia in the AH displayed elongated somata with tightly surrounding motoneurons, whereas cells in the PH displayed a rather ameboid morphology and were attached to myelin sheaths rather than to neurons. Microglia in the AH strongly expressed NG2 chondroitin sulfate proteoglycan. Despite the tight attachment to neurons in the AH, a reduction in synaptic proteins was not evident, suggesting engagement of the activated microglia in synaptic stripping. Myelin basic protein immunoreactivity was observed in the phagosomes of activated microglia in the PH, suggesting the phagocytic removal of myelin. CCI caused both motor deficit and hyperalgesia that were evaluated by applying BBB locomotor rating scale and von Frey test, respectively. Motor defict was the most evident at postoperative day1, and that became less significant thereafter. By contrast, hyperalgesia was not severe at day 1 but it became worse at least by day 7. Collectively, the activation modes of microglia were different between the AH and PH, which may be associated with the difference in the course of motor and sensory symptoms.
Published: 2020

118. Spatiotemporal Characteristics of Cortical Activities Associated with Articulation of Speech Perception

Author: Seiji Nakagawa, Tetsuya Takiguchi, Hajime Yano, Naoki Saga, and Yoshiharu Soeta
Subjects: 0301 basic medicine, medicine.medical_specialty, Speech perception, media_common.quotation_subject, Audiology, Auditory cortex, 03 medical and health sciences, 0302 clinical medicine, Perception, medicine, Humans, Speech, media_common, Brain–computer interface, Auditory Cortex, Brain Mapping, Brain, Human brain, Speech processing, Broca Area, 030104 developmental biology, medicine.anatomical_structure, Speech Perception, Noise (video), Articulation (phonetics), Psychology, 030217 neurology & neurosurgery
Abstract: Recently, brain computer interface (BCI) technologies that control external devices with human brain signals have been developed. However, most of the BCI systems, such as P300-speller, can only discriminate among options that have been given in advance. Therefore, the ability to decode the state of a person's perception and recognition, as well as that person's fundamental intention and emotions, from cortical activity is needed to develop a more general-use BCI system. In this study, two experiments were conducted. First, articulations were measured for Japanese monosyllabic utterances masked by several levels of noise. Second, auditory brain magnetic fields evoked by the monosyllable stimuli used in the first experiment were recorded, and neuronal current sources were localized in regions associated with speech perception and recognition - the auditory cortex (BA41), the Wernicke's area (posterior part of BA22), Broca's area (BA22), motor (BA4), and premotor (BA6) areas. Although the source intensity did not systematically change with SNR, the peak latency changed along SNR in the posterior superior temporal gyrus in the right hemisphere. The results suggest that the information associated with articulation is processed in this area.
Published: 2018

119. CBMS-04 SIGNIFICANT ROLE OF HYPOXIA IN THE EXPRESSION AND FUNCTION OF OSTEOPONTIN IN CD44-HIGHLY EXPRESSED GLIOMA STEM-LIKE CELLS IN TUMOR PROGRESSION OF GLIOBLASTOMA

Author: Shirabe Matsumoto, Hajime Yano, Takanori Ohnishi, Satoshi Suehiro, Yonehiro Kanemura, Saya Ozaki, Yoshihiro Ohtsuka, Takeharu Kunieda, Junya Tanaka, Masahiro Nishikawa, and Akihiro Inoue
Subjects: biology, CD44, Hypoxia (medical), medicine.disease, Phenotype, Abstracts, stomatognathic system, Tumor progression, Cancer stem cell, Cell Biology/Metabolism/Stem Cells (Cbms), Glioma, medicine, biology.protein, Cancer research, Osteopontin, medicine.symptom, Glioblastoma
Abstract: The poor prognosis of glioblastoma multiforme (GBM) may be due to the surviving glioma stem-like cells (GSCs) in the tumor periphery after tumor resection. We demonstrated that CD44-expressed GSCs existed much more in the tumor periphery of high invasive (HI) type GBM than low invasive (LI) type GBM. The HI type was significantly associated with worse outcome, but how GSCs with high CD44 expression relate to tumor progression remains unknown. In this study, we investigated effects of hypoxia on CD44-directed signal pathways, leading to tumor invasion and proliferation in GBM. We focused on the CD44 ligand osteopontin (OPN) because it is known hypoxia affects the interaction of CD44 and OPN which promotes stemness and proliferation of cancer stem cells. We examined mRNA expressions of hypoxia inducible factor (HIF)-1a, HIF-2a, CD44 and OPN in tumor tissues of GBM and investigated effects of hypoxia (1%O2:severe or 5%O2:moderate) on the expression of these molecules using cultured GSCs that were established from tumor tissues showing high CD44 expression in the periphery of GBMs. In addition, we analyzed the effects of OPN on invasive, migratory and proliferative activities of GSCs under the hypoxic conditions. OPN was much higher expressed in the tumor periphery of LI type GBM than HI type GBM. Severe hypoxia significantly increased the expressions of HIF-1a and CD44 but did not OPN. On the other hands, moderate hypoxia promoted the expressions of HIF-2a and OPN. Knockdown of HIF-2a significantly inhibited OPN expression. In addition, the more OPN was expressed in the cultured GSCs under moderate hypoxia, the more the GSCs proliferated and decreased their invasive and migratory activities. In conclusion, GSCs existing in the tumor periphery of GBM can migrate or proliferate by changing CD44-directed signal pathways. Moderate hypoxia promoted HIF-2a/OPN/CD44 pathway, resulting in phenotypic transition to high proliferative tumors.
Published: 2019

120. Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson's disease model

Author: Mohammed E. Choudhury, Madoka Kubo, Masahiro Nomoto, Hajime Yano, Minori Watanabe, Kazuya Miyanishi, and Junya Tanaka
Subjects: 0301 basic medicine, Male, Parkinson's disease, Apomorphine, Substantia nigra, Striatum, Motor Activity, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, Animals, Rats, Wistar, Tyrosine hydroxylase, Behavior, Animal, business.industry, Dopaminergic, Parkinson Disease, Cell Biology, medicine.disease, Corpus Striatum, Substantia Nigra, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Metabotropic glutamate receptor, Behavior Rating Scale, Dopamine Agonists, Nerve Degeneration, Forelimb, business, Neuroscience, 030217 neurology & neurosurgery, medicine.drug
Abstract: Parkinson's disease (PD) is a frequent neurodegenerative disease causing bradykinesia, tremor, muscle rigidity and postural instability. Although its main pathology is progressive dopaminergic (DArgic) neuron loss in the substantia nigra, motor deficits are thought not to become apparent until most DArgic neurons are lost, probably due to compensatory mechanisms that overcome the decline of DA level in the striatum. Even in animal PD models, it is difficult to detect motor deficits when most DArgic neurons are functional. In this study, we performed various behavioral tests (apomorphine-induced rotation, cylinder, forepaw adjustment steps (FAS), beam walking, rota-rod, and open-field), using 6-hydroxydopamine (OHDA) and lipopolysaccharide (LPS)-induced hemi-PD model rats with various striatal DA levels, to find the best way to predict the DA level from earlier disease stages. Different from the 6-OHDA-induced model, reduction in the striatal DA levels in the LPS-model was less significant. Among the behavioral tests, data from cylinder and FAS tests, which evaluate forelimb movements, best correlated with decline of the DA level. They also correlated well with decreased body weight gain. The beam and apomorphine tests showed less significant correlation than the cylinder and FAS tests. Open-field and rota-rod tests were not useful. Expressional levels of mRNA encoding tyrosine hydroxylase (TH), a marker of DArgic neurons, correlated well with the DA level. Metabotropic glutamate receptor 4 mRNA expression correlated with the striatal DA level and may be related to compensatory mechanisms. These results suggest that motor impairments of PD should be evaluated by forelimb movements, or hands and forearms in clinical settings, rather than movement of the body or large joints. The combination of cylinder and FAS tests may be the best to evaluate the rat PD models, in which many DArgic neurons survive.
Published: 2018

121. Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea

Author: Naoki Abe, Shun Kawasaki, Shirabe Matsumoto, Takehiro Kunieda, Minori Watanabe, Yoshiaki Kumon, Mohammed E. Choudhury, Tasuku Nishihara, Hajime Yano, Junya Tanaka, and Toshihiro Yorozuya
Subjects: 0301 basic medicine, Mitochondrial ROS, Male, Chemokine, medicine.medical_treatment, Wounds, Stab, CCL2, Proinflammatory cytokine, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Prosencephalon, Brain Injuries, Traumatic, medicine, Animals, Hypnotics and Sedatives, RNA, Messenger, Rats, Wistar, Cells, Cultured, Chemokine CCL2, NADPH oxidase, biology, Microglia, CD68, Growth factor, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, nervous system, Neurology, biology.protein, Cancer research, Bromisovalum, 030217 neurology & neurosurgery
Abstract: Microglia and blood-borne macrophages in injured or diseased brains are difficult to distinguish because they share many common characteristics. However, the identification of microglia-specific markers and the use of flow cytometry have recently made it easy to discriminate these types of cells. In this study, we analyzed the features of blood-borne macrophages, and activated and resting microglia in a rat traumatic brain injury (TBI) model. Oxidative injury was indicated in macrophages and neurons in TBI lesions by the presence of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Generation of mitochondrial reactive oxygen species (ROS) was markedly observed in granulocytes and macrophages, but not in activated or resting microglia. Dihydroethidium staining supported microglia not being the major source of ROS in TBI lesions. Furthermore, macrophages expressed NADPH oxidase 2, interleukin-1β (IL-1β), and CD68 at higher levels than microglia. In contrast, microglia expressed transforming growth factor β1 (TGFβ1), interleukin-6 (IL-6), and tumor necrosis factor α at higher levels than macrophages. A hypnotic, bromovalerylurea (BU), which has anti-inflammatory effects, reduced both glycolysis and mitochondrial oxygen consumption. BU administration inhibited chemokine CCL2 expression, accumulation of monocytes/macrophages, 8-OHdG generation, mitochondrial ROS generation, and proinflammatory cytokine expression, and markedly ameliorated the outcome of the TBI model. Yet, BU did not inhibit microglial activation or expression of TGFβ1 and insulin-like growth factor 1 (IGF-1). These results indicate that macrophages are the major aggravating cell type in TBI lesions, in particular during the acute phase. Activated microglia may even play favorable roles. Reduction of cellular energy metabolism in macrophages and suppression of CCL2 expression in injured tissue may lead to amelioration of TBI.
Published: 2018

122. Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

Author: Shohei Kohno, Hisaaki Takahashi, Riko Kitazawa, Hideaki Watanabe, Daisuke Yamashita, Satoshi Suehiro, Takeharu Kunieda, Akihiro Inoue, Junya Tanaka, Shirabe Matsumoto, Hajime Yano, Takanori Ohnishi, Saya Ozaki, Shiro Ohue, and Masahiro Nishikawa
Subjects: 0301 basic medicine, endocrine system, lcsh:Internal medicine, Article Subject, Stem cell marker, 03 medical and health sciences, chemistry.chemical_compound, Glioma, medicine, lcsh:RC31-1245, Molecular Biology, Gene knockdown, biology, CD44, fungi, Cell Biology, medicine.disease, Phenotype, Vascular endothelial growth factor, 030104 developmental biology, chemistry, Tumor progression, biology.protein, Cancer research, Chemoradiotherapy, Research Article
Abstract: Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be removed during tumor resection, it is very important to know where surviving GSCs are localized. Here, we investigated the existence and functions of GSCs in the tumor periphery, which is considered to constitute the invasion niche for GSCs in GBM, by analyzing expression of stem cell markers and stem cell-related molecules and measuring particular activities of cultured GSCs. In addition, the relationship between GSCs expressing particular stem cell markers and pathological features on MRI and prognosis in GBM patients was analyzed. We showed that GSCs that express high levels of CD44 are present in the tumor periphery. We also found that vascular endothelial growth factor (VEGF) is characteristically expressed at a high level in the tumor periphery. Cultured GSCs obtained from the tumor periphery were highly invasive and have enhanced migration phenotype, both of which were markedly inhibited by CD44 knockdown. Higher expression of CD44 in the tumor periphery than in the core was correlated with a highly invasive feature on MRI and was associated with early tumor progression and worse survival, whereas lower expression of CD44 in the tumor periphery corresponded to low invasion and was associated with longer survival. The low invasion type on MRI tended to show high levels of VEGF expression in the tumor periphery, thus presenting the tumor with high proliferative activity. These results imply the significance of GSCs with high levels of CD44 expression in the tumor periphery compared to the core, not only in tumor invasion but also rapid tumor progression and short survival in patients with GBM.
Published: 2018

123. EUSO-TA - First results from a ground-based EUSO telescope

Author: N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Pavol Bobik, M. Haiduc, Lech Wiktor Piotrowski, S. Bartocci, J. A. Morales de los Ríos, N. Belkhalfa, Susumu Inoue, S. Yoshida, J. Szabelski, S. B. Thomas, K. Kudela, M. D. Rodríguez Frías, Naoto Sakaki, Z. Plebaniak, Thomas Schanz, Michiyuki Chikawa, M. Di Martino, A. Marini, Toshikazu Ebisuzaki, G. Roudil, B. Harlov, J. F. Valdés-Galicia, G. Osteria, Carlo Vigorito, L. G. Tkachev, Josef Jochum, S. Naitamor, G. Vankova, A. Caramete, Livio Conti, K. Martens, D. Maravilla, L. López Campano, J. Fernández-Soriano, R. Matev, Yoshihiko Mizumoto, Sebastián Franchini, S. Biktemerova, A. Ebersoldt, Daisuke Ikeda, A. Zuccaro Marchi, Hajime Takami, Masaki Fukushima, E. G. Judd, O. Larsson, H. J. Crawford, M. Serra, Jörn Wilms, J. Karczmarczyk, M. Ave Pernas, D. Kolev, H. Krantz, Mohammed Bakiri, Luis A. Anchordoqui, I. Kaneko, O. A. Saprykin, Estíbaliz Gascón, S. Turriziani, A. Belov, Valerie Connaughton, L. Marcelli, Konstantin Belov, A. Anzalone, T. Napolitano, Toshitaka Kajino, Francesco Fenu, N. Tone, Christer Fuglesang, Humberto Ibarguen Salazar, K. Benmessai, A. Guzmán, C. Lachaud, Daisuke Yonetoku, J. Blecki, José Meseguer, Angel Sanz-Andrés, Shinsuke Abe, P. Galeotti, R. Attallah, J. Hernández Carretero, H. Tokuno, B. Beldjilali, Takayuki Tomida, Santiago Pindado, S. Jeong, T. Shirahama, Y. Tsunesada, Junpei Fujimoto, M. Yu. Zotov, Silvia Ferrarese, Katsuaki Asano, Alfonso Monaco, H. Attoui, E. M. Popescu, B. A. Khrenov, A. Pagliaro, J. Genci, L. Villaseñor, C. Tenzer, T. Sugiyama, Piergiorgio Picozza, R. Tsenov, Satoshi Wada, N. Mebarki, W. Painter, Piotr Orleanski, T. Paul, A. Pollini, Pavel Klimov, B. Panico, Y. Karadzhov, Isabel Pérez-Grande, F. Sarazin, Zbigniew Wlodarczyk, Marc Weber, F. Bisconti, C. González Alvarado, Tokonatsu Yamamoto, E. Bozzo, T. Ogawa, M. C. Talai, J.N. Capdevielle, G. Sáez Cano, Angela V. Olinto, Javier Licandro, M. Rezazadeh, Andrea Santangelo, A. Kusenko, Katsuhiko Tsuno, Yoshio Arai, I. Kreykenbohm, Pierre Sokolsky, G. Masciantonio, Y. Martín, S. Selmane, John Belz, L. Placidi, M. Kleifges, P. L. Biermann, Tomás Belenguer, Yoshitaka Itow, N. Tajima, Giuseppe Giraudo, M. Takeda, M. A. Mendoza, G. Medina-Tanco, Shigehiro Nagataki, Barbara Szabelska, T. Peter, O. Martinez, Gordon Thomson, Toshiyuki Nonaka, F. Ronga, Gustavo Alonso, J. Watanabe, J. Tubbs, I. Rusinov, I. V. Yashin, M. Fouka, Osvaldo Catalano, M. Martucci, Fausto Guarino, J. Yang, P. von Ballmoos, M. Ricci, H. Miyamoto, M. Sanz Palomino, S. E. Csorna, Amine Ahriche, Simona Toscano, A. Bruno, Jeong-Sook Kim, Kenji Shinozaki, L. Caramete, Marcos Reyes, Roberto Bellotti, K. Mase, Gali Garipov, Joowon Lee, M. Flamini, B. Vlcek, T. Patzak, James H. Adams, H. Prieto, N. Blanc, R. Cremonini, S. Dagoret-Campagne, Francesca Capel, Y. Takizawa, S. Mackovjak, J. L. Marcos, E. Kuznetsov, G. Puehlhofer, D. Supanitsky, R. Weigand Muñoz, P. Gorodetzky, Shoichi Ogio, Johannes Eser, P. Baragatti, Austin Cummings, M. Wille, Y. Uchihori, A. La Barbera, Guillaume Prévôt, S. Blin-Bondil, R. Greg, I. Stan, G. Cordero, Malek Mustafa, J. Mimouni, M. Bogomilov, Z. Polonski, D. Campana, H. Khales, L. Allen, F. Lakhdari, F. Kajino, Maciej Rybczyński, Inkyu Park, M. Putis, S. S. Meyer, A. Weindl, Mark Christl, O. Tibolla, S. Pliego, K. Kawai, Akinori Saito, Ovidiu Vaduvescu, Claudio Cassardo, Dmitri Semikoz, Andrés Merino, P. Carlson, Yuichiro Tameda, John N. Matthews, M. Traïche, F. Cafagna, E. Joven, Y. Hachisu, F. Perfetto, Bruno Spataro, B. Pastirčák, Pierre Barrillon, Eduardo García-Ortega, Sergei A. Sharakin, Piero Vallania, R. Young, Yukihiro Takahashi, José Luis Sánchez, M. D. Sabau, M. Suzuki, Marco Casolino, Claudio Fornaro, Mikhail Panasyuk, A. Neronov, Sergio Fernández-González, J. Bayer, M. C. Maccarone, Valentina Scotti, C. de la Taille, A. Kedadra, I. Dutan, I. S. Zgura, G. Cotto, K. Katahira, M. Mahdi, C. De Donato, Soon-Wook Kim, Yoshimasa Kurihara, G. Chiritoi, H. Schieler, A. Jung, A. Haungs, S. Piraino, H. Lahmar, Antonella Castellina, Mitsuteru Sato, T. Jammer, J. Rabanal, G. Abdellaoui, Hajime Yano, Heungsu Shin, R. Nava, Ralph Engel, Takahiro Fujii, Rossella Caruso, Toshiki Tajima, Hitoshi Ohmori, K. S. Caballero, Hiroyuki Sagawa, Yoshiya Kawasaki, A. Radu, A. Menshikov, Hirohiko M. Shimizu, T. Djemil, D. Allard, Alberto Cellino, S. Kalli, J. Watts, M. E. Bertaina, C. De Santis, L. R. Wiencke, M. Vrabel, P. Prat, Ken'ichi Nomoto, Z. Sahnoune, W. Hidber Cruz, S. Bacholle, Francesco Isgrò, W. Marszał, J. C. Sanchez Balanzar, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Belz, J. W., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., González Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., López Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J., Marini, A., Marszal, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mustafa, M., Matev, R., Matthews, J., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Ríos, J. A., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez Frías, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M., Sáez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shin, H. S., Shinozaki, K., Shirahama, T., Sokolsky, P., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Thomson, G. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Muñoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., Zuccaro Marchi, A., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Fresnel lens, Photomultiplier, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Night sky, JEM-EUSO, Cosmic ray, Field of view, Astrophysics::Cosmology and Extragalactic Astrophysics, 7. Clean energy, 01 natural sciences, cosmic rays, EAS, UHECR, Astronomy and Astrophysics, Aeronáutica, law.invention, Telescope, law, 0103 physical sciences, Ultra-high-energy cosmic ray, 010303 astronomy & astrophysics, cosmic ray, Astrophysique, Physics, Fresnel len, 010308 nuclear & particles physics, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomie, Astronomía, Limiting magnitude, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: EUSO-TA is a ground-based telescope, installed at the Telescope Array (TA) site in Black Rock Mesa, Utah, USA. This is the first detector to successfully use a Fresnel lens based optical system and multi-anode photomultipliers (64 channels per tube, 2304 channels encompassing a 10.6° × 10.6° field of view) for detection of Ultra High Energy Cosmic Rays (UHECR). The telescope is located in front of one of the fluorescence detectors of the TA experiment. Since its installation in 2013, the detector has observed several ultra-high energy cosmic ray events and, in addition, meteors. The limiting magnitude of 5.5 on summed frames (∼ 3 ms) has been established. Measurements of the UV night sky emission in different conditions and moon phases and positions have been completed. The performed observations serve as a proof of concept for the future application of this detector technology., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2018

124. Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

Author: Hajime Yano, Ayu Kawakami, Junya Tanaka, Hisaaki Takahashi, Afsana Islam, Ayaka Yamaizumi, Mohammed E. Choudhury, and Yurika Ishii
Subjects: Lipopolysaccharides, Agonist, medicine.medical_specialty, Adrenergic receptor, medicine.drug_class, Active Transport, Cell Nucleus, Anti-Inflammatory Agents, Nitric Oxide, Proinflammatory cytokine, Norepinephrine, Cellular and Molecular Neuroscience, Internal medicine, medicine, Animals, STAT1, Phosphorylation, Cells, Cultured, biology, Interleukin-6, Kinase, NF-kappa B, Cell Biology, Rats, Cell biology, STAT1 Transcription Factor, Endocrinology, biology.protein, TLR4, Microglia, Signal transduction, Signal Transduction
Abstract: Noradrenaline (NA) has marked anti-inflammatory effects on activated microglial cells. The present study was conducted to elucidate the mechanisms underlying the NA effects using rat primary cultured microglial cells. NA, an α1 agonist, phenylephrine (Phe) and a β2 agonist, terbutaline (Ter) suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) release by microglia and prevented neuronal degeneration in LPS-treated neuron-microglia coculture. The agents suppressed expression of mRNA encoding proinflammatory mediators. Both an α1-selective blocker terazocine and a β2-selective blocker butoxamine overcame the suppressive effects of NA. cAMP-dependent kinase (PKA) inhibitors did not abolish the suppressive NA effects. LPS decreased IκB leading to NFκB translocation into nuclei, then induced phosphorylation of signal transducer and activator of transcription 1 (STAT1) and expression of interferon regulatory factor 1 (IRF1). NA inhibited LPS-induced these changes. When NFκB expression was knocked down with siRNA, LPS-induced STAT1 phosphorylation and IRF1 expression was abolished. NA did not suppress IL-6 induced STAT1 phosphorylation and IRF1 expression. These results suggest that one of the critical mechanisms underlying the anti-inflammatory effects of NA is the inhibition of NFκB translocation. Although inhibitory effects of NA on STAT1 phosphorylation and IRF1 expression may contribute to the overall suppressive effects of NA, these may be the downstream events of inhibitory effects on NFκB. Since NA, Phe and Ter exerted almost the same effects and PKA inhibitors did not show significant antagonistic effects, the suppression by NA might not be dependent on specific adrenergic receptors and cAMP-dependent signaling pathway.
Published: 2015

125. DIVISION F COMMISSION 15: PHYSICAL STUDY OF COMETS AND MINOR PLANETS

Author: Dominique Bockelée-Morvan, Ricardo Gil-Hutton, Daniel Hestroffer, Irina N. Belskaya, Björn J. R. Davidsson, Elisabetta Dotto, Alan Fitzsimmons, Hideyo Kawakita, Thais Mothe-Diniz, Javier Licandro, Diane H. Wooden, Hajime Yano, Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Planetology and Environments from Ground Astrometry and Space Exploration (PEGASE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris
Subjects: Solar System, 010504 meteorology & atmospheric sciences, business.industry, Numerical modeling, Astronomy and Astrophysics, Commission, 01 natural sciences, Astrobiology, Geography, Space and Planetary Science, Asteroid, 0103 physical sciences, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Telecommunications, business, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract: Commission 15 of the International Astronomical Union (IAU), entitled Physical Study of Comets and Minor Planets, was founded in 1935 and dissolved in 2015, following the reorganization of IAU. In 80 years of Commission 15, tremendous progress has been made on the knowledge of these objets, thanks to the combined efforts of ground- and space-based observations, space mission rendezvous and flybys, laboratory simulation and analyses of returned samples, and theoretical and numerical modeling. Together with dynamical studies of the Solar System, this discipline has provided a much deeper understanding of how the Solar System formed and evolved. We present a legacy report of Commission 15, which highlights key milestones in the exploration and knowledge of the small bodies of the Solar System.
Published: 2015

126. Silica Aerogel for Capturing Intact Interplanetary Dust Particles for the Tanpopo Experiment

Author: Hajime Yano, Yuko Kawaguchi, Akihiko Yamagishi, Makoto Tabata, Eiichi Imai, Hirofumi Hashimoto, and Hideyuki Kawai
Subjects: Physics - Instrumentation and Detectors, Silica aerogel, FOS: Physical sciences, Silica Gel, International Space Station, Interplanetary dust cloud, Framing (construction), Qualification testing, Exobiology, Aerospace engineering, Spacecraft, Instrumentation and Methods for Astrophysics (astro-ph.IM), Ecology, Evolution, Behavior and Systematics, Cosmic dust, Earth and Planetary Astrophysics (astro-ph.EP), business.industry, Aerogel, Instrumentation and Detectors (physics.ins-det), General Medicine, Astrobiology, Tanpopo, Space and Planetary Science, Environmental science, Astrophysics - Instrumentation and Methods for Astrophysics, business, Astrophysics - Earth and Planetary Astrophysics
Abstract: In this paper, we report the progress in developing a silica-aerogel-based cosmic dust capture panel for use in the Tanpopo experiment on the International Space Station (ISS). Previous studies revealed that ultralow-density silica aerogel tiles comprising two layers with densities of 0.01 and 0.03 g/cm$^3$ developed using our production technique were suitable for achieving the scientific objectives of the astrobiological mission. A special density configuration (i.e., box framing) aerogel with a holder was designed to construct the capture panels. Qualification tests for an engineering model of the capture panel as an instrument aboard the ISS were successful. Sixty box-framing aerogel tiles were manufactured in a contamination-controlled environment., Comment: Proceedings of 2nd Joint International Conference, ISSOL - the International Astrobiology Society and Bioastronomy (Commission 51 of the International Astronomical Union) (Origins 2014), published in Orig. Life Evol. Biosph., 6 pages, 1 figure
Published: 2015

127. CD200+ and CD200− macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages

Author: Hitomi Aono, Takanori Ohnishi, Akari Kusakawa, Akihiro Inoue, Shirabe Matsumoto, Junya Tanaka, Yoshiaki Kumon, Hideaki Watanabe, Shiro Ohue, Hajime Yano, Kana Sugimoto, and Hisaaki Takahashi
Subjects: Male, medicine.medical_treatment, Adipose tissue macrophages, Immunology, Nitric Oxide Synthase Type II, Cell Count, Biology, Rats, Sprague-Dawley, chemistry.chemical_compound, Antigens, CD, medicine, Animals, Immunology and Allergy, Macrophage, Antigens, Insulin-Like Growth Factor I, Rats, Wistar, Bone Marrow Transplantation, CD86, CD68, Macrophages, Growth factor, Calcium-Binding Proteins, Microfilament Proteins, Brain, Infarction, Middle Cerebral Artery, Molecular biology, Rats, Toll-Like Receptor 4, Disease Models, Animal, Ki-67 Antigen, Gene Expression Regulation, nervous system, Neurology, chemistry, Chondroitin sulfate proteoglycan, TLR4, Cancer research, Cytokines, Proteoglycans, Neurology (clinical), Rats, Transgenic, Transforming growth factor
Abstract: Two types of macrophages in lesion core of rat stroke model were identified according to NG2 chondroitin sulfate proteoglycan (NG2) and CD200 expression. NG2 + macrophages were CD200 − , and vice versa. NG2 − macrophages expressed two splice variants of CD200 that are CD200L and CD200S. CD200 + macrophages expressed CD8, CD68, CD163, CCL2, inducible nitric oxide synthase, interleukin-1β, Toll-like receptor 4 and transforming growth factor β, whilst NG2 + cells expressed a costimulatory factor CD86. Both cell types expressed insulin-like growth factor 1 and CD200R. These results demonstrate that the two macrophage types cannot be classified as either M1 or M2.
Published: 2015

128. The ameliorative effects of a hypnotic bromvalerylurea in sepsis

Author: Takumi Nagaro, Yuji Watanabe, Tasuku Nishihara, Junya Tanaka, Jun Kuwabara, Satoshi Kikuchi, Shun Kawasaki, Hajime Yano, Mayuki Aibiki, Hisaaki Takahashi, Mohammed E. Choudhury, and Naoki Abe
Subjects: Lipopolysaccharides, Male, medicine.medical_specialty, medicine.drug_class, Multiple Organ Failure, Biophysics, Inflammation, Biochemistry, Gastroenterology, Hypnotic, Sepsis, Pathogenesis, Interferon-gamma, Internal medicine, medicine, Animals, Humans, Hypnotics and Sedatives, Macrophage, RNA, Messenger, Rats, Wistar, Respiratory system, Molecular Biology, Interleukin-6, business.industry, Macrophages, Cell Biology, medicine.disease, Rats, Disease Models, Animal, STAT1 Transcription Factor, Immunology, Circulatory system, TLR4, Cytokines, I-kappa B Proteins, Bromisovalum, medicine.symptom, business
Abstract: Sepsis is a severe pathologic event, frequently causing death in critically ill patients. However, there are no approved drugs to treat sepsis, despite clinical trials of many agents that have distinct targets. Therefore, a novel effective treatment should be developed based on the pathogenesis of sepsis. We recently observed that an old hypnotic drug, bromvalerylurea (BU) suppressed expression of many kinds of pro- and anti-inflammatory mediators in LPS- or interferon-γ activated alveolar and peritoneal macrophages (AMs and PMs). Taken the anti-inflammatory effects of BU on macrophages, we challenged it to septic rats that had been subjected to cecum-ligation and puncture (CLP). BU was subcutaneously administered to septic rats twice per day. Seven days after CLP treatment, 85% of septic rats administrated vehicle had died, whereas administration of BU reduce the rate to 50%. Septic rats showed symptoms of multi-organ failure; respiratory, circulatory and renal system failures as revealed by histopathological analyses, blood gas test and others. BU ameliorated these symptoms. BU also prevented elevated serum-IL-6 level as well as IL-6 mRNA expression in septic rats. Collectively, BU might be a novel agent to ameliorate sepsis by preventing the onset of MOF.
Published: 2015

129. Cellular mechanotransduction of physical force and organ response to exercise-induced mechanical stimuli

Author: Mohammed E. Choudhury, Afsana Islam, Kana Kobayashi, Junya Tanaka, and Hajime Yano
Subjects: Cellular mechanotransduction, mechanostimuli, Physiology, Chemistry, human body, Sports medicine, QP1-981, mechanosensors, signal processing, RC1200-1245, Cell biology
Abstract: The variable effects of mechanical stimuli induced by exercise on the human body are becoming better understood. Additionally, the indispensable effect of constant gravity on the human body to construct and maintain living organisms is known from observed muscle and bone regression induced by long-term recumbency or visits to gravity-free environments, such as space. Based on reactions of the body, cells faced with various inputs largely depend on gene expression, biochemical processes, or both. Thus, it is easy to imagine that physical input can be converted into a chemical process. The conversion process that changes physical forces (mechanical stimuli) into chemical reactions in a cell is called mechanotransduction. A growing number of studies examining mechanotransduction have led to a new phase in the understanding of exercise-induced effects on organisms.
Published: 2015

130. Impact Frequency Estimate of Micron-sized Meteoroids and Debris on Tanpopo Capture Panels on the ISS

Author: Kazuyoshi Arai, Masumi Higashide, Manami Kurihara, Makoto Tabata, Yuu Takayanagi, Akihiko Yamagishi, Sunao Hasegawa, and Hajime Yano
Subjects: Meteoroid, business.industry, Projectile, ISS, General Medicine, Debris, Astrobiology, Impact crater, International Space Station, Risk assessment code, Impact frequency, Hypervelocity, Impact energy, Environmental science, Crater equation, Space debris, Aerospace engineering, business, Engineering(all)
Abstract: This study is a part of ‘Tanpopo’ mission, which is to be mounted on the Exposure Facility of the Japanese “Kibo” Module of the International Space Station. The purpose of this study is to comparing the impact frequency that is predicted from the debris environment model and the impact craters on the exposed instrument. There are two approaches to achieve this plan. The first is to predict the impact frequency of the micron-sized debris onto the Tanpopo capture panels which is exposed to space. The second is to establish methods for calculating key parameters in relation to impacting debris particles from excavated craters on the capture panel material. The debris impact frequency on the capture panels was predicted using the impact-risk analysis tool. It was found that impact of particles of 10 μm or less in diameter was expected on the panels. Additionally, the relationship between the debris impact energy and crater was also derived by hypervelocity impact experiments. It was found that regardless of the projectile materials and impact speed, the relationship between the impact energy and the crater volume is nearly proportional.
Published: 2015
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131. Induced brain magnetic activities related to salient birdsong under noisy conditions.

Author: Hajime Yano and Yoshiharu Soeta
Published: 2021
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132. Cerebral Air Embolism as a Complication of Subcutaneous Injection

Author: Toshio Fukutake, Sandra Y. Moody, Hajime Yano, Ryota Sato, and Sarah Kyuragi Luthe
Subjects: Male, medicine.medical_specialty, Analgesics, Hyperbaric Oxygenation, business.industry, Heparin, Hyperbaric oxygenation, Injections, Subcutaneous, Anticoagulants, General Medicine, medicine.disease, Air embolism, Surgery, Subcutaneous injection, Embolism, Intracranial Embolism, Anesthesia, medicine, Embolism, Air, Humans, business, Complication, Myofascial Pain Syndromes, Aged
Published: 2017

133. Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus

Author: Kazuya Miyanishi, Madoka Kubo, Yuka Kigami, Hitomi Aono, Hajime Yano, Mohammed E. Choudhury, Kohdai Fujita, Noriko Nishikawa, Junya Tanaka, Hisaaki Takahashi, Jun-ichi Akiyama, Masahiro Nomoto, and Hiromi Higaki
Subjects: 0301 basic medicine, Male, Dopamine, Glutamic Acid, Substantia nigra, Biology, Motor Activity, Indirect pathway of movement, 03 medical and health sciences, Cellular and Molecular Neuroscience, Glutamatergic, 0302 clinical medicine, Prosencephalon, Parkinsonian Disorders, Phagocytosis, Subthalamic Nucleus, Basal ganglia, Animals, Rats, Wistar, Oxidopamine, Cells, Cultured, Pars compacta, Dopaminergic Neurons, Rats, Subthalamic nucleus, Disease Models, Animal, 030104 developmental biology, nervous system, Neurology, Animals, Newborn, Synapses, Exploratory Behavior, Sympatholytics, Microglia, Pars reticulata, Neuroscience, Postsynaptic density, 030217 neurology & neurosurgery
Abstract: Parkinson's disease (PD) symptoms do not become apparent until most dopaminergic neurons in the substantia nigra pars compacta (SNc) degenerate, suggesting that compensatory mechanisms play a role. Here, we investigated the compensatory involvement of activated microglia in the SN pars reticulata (SNr) and the globus pallidus (GP) in a 6-hydroxydopamine-induced rat hemiparkinsonism model. Activated microglia accumulated more markedly in the SNr than in the SNc in the model. The cells had enlarged somata and expressed phagocytic markers CD68 and NG2 proteoglycan in a limited region of the SNr, where synapsin I- and postsynaptic density 95-immunoreactivities were reduced. The activated microglia engulfed pre- and post-synaptic elements, including NMDA receptors into their phagosomes. Cells in the SNr and GP engulfed red fluorescent DiI that was injected into the subthalamic nucleus (STN) as an anterograde tracer. Rat primary microglia increased their phagocytic activities in response to glutamate, with increased expression of mRNA encoding phagocytosis-related factors. The synthetic glucocorticoid dexamethasone overcame the stimulating effect of glutamate. Subcutaneous single administration of dexamethasone to the PD model rats suppressed microglial activation in the SNr, resulting in aggravated motor dysfunctions, while expression of mRNA encoding glutamatergic, but not GABAergic, synaptic elements increased. These findings suggest that microglia in the SNr and GP become activated and selectively eliminate glutamatergic synapses from the STN in response to increased glutamatergic activity. Thus, microglia may be involved in a negative feedback loop in the indirect pathway of the basal ganglia to compensate for the loss of dopaminergic neurons in PD brains.
Published: 2017

134. Effects of hypnotic bromovalerylurea on microglial BV2 cells

Author: Mohammed E. Choudhury, Shun Kawasaki, Afsana Islam, Mayuki Aibiki, Naoki Abe, Satoshi Kikuchi, Junya Tanaka, Jun Kuwabara, Toshihiro Yorozuya, Ryo Utsunomiya, Tasuku Nishihara, Fumito Ohtake, Hajime Yano, and Yuji Watanabe
Subjects: 0301 basic medicine, Lipopolysaccharides, Filgotinib, Macrophage, Acute Lung Injury, Anti-Inflammatory Agents, Pharmacology, Nitric Oxide, NO, Proinflammatory cytokine, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adenosine Triphosphate, Rotenone, Animals, Hypnotics and Sedatives, STAT1, Phosphorylation, Rats, Wistar, biology, Janus kinase 1, Electron Transport Complex II, Macrophages, lcsh:RM1-950, NF-kappa B, Janus Kinase 1, ATP, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, IRF1, STAT1 Transcription Factor, Biochemistry, chemistry, STAT protein, biology.protein, Molecular Medicine, Cytokines, Microglia, Bromisovalum, 030217 neurology & neurosurgery, Interferon Regulatory Factor-1
Abstract: An old sedative and hypnotic bromovalerylurea (BU) has anti-inflammatory effects. BU suppressed nitric oxide (NO) release and proinflammatory cytokine expression by lipopolysaccharide (LPS)-treated BV2 cells, a murine microglial cell line. However, BU did not inhibit LPS-induced nuclear translocation of nuclear factor-κB and subsequent transcription. BU suppressed LPS-induced phosphorylation of signal transducer and activator of transcription 1 (STAT1) and expression of interferon regulatory factor 1 (IRF1). The Janus kinase 1 (JAK1) inhibitor filgotinib suppressed the NO release much more weakly than that of BU, although filgotinib almost completely prevented LPS-induced STAT1 phosphorylation. Knockdown of JAK1, STAT1, or IRF1 did not affect the suppressive effects of BU on LPS-induced NO release by BV2 cells. A combination of BU and filgotinib synergistically suppressed the NO release. The mitochondrial complex I inhibitor rotenone, which did not prevent STAT1 phosphorylation or IRF1 expression, suppressed proinflammatory mediator expression less significantly than BU. BU and rotenone reduced intracellular ATP (iATP) levels to a similar extent. A combination of rotenone and filgotinib suppressed NO release by LPS-treated BV2 cells as strongly as BU. These results suggest that anti-inflammatory actions of BU may be attributable to the synergism of inhibition of JAK1/STAT1-dependent pathways and reduction in iATP level.
Published: 2017

135. Elevated Na

Author: Teppei, Kaminota, Hajime, Yano, Kohei, Shiota, Noriko, Nomura, Haruna, Yaguchi, Yui, Kirino, Kentaro, Ohara, Issei, Tetsumura, Tomoyoshi, Sanada, Toru, Ugumori, Junya, Tanaka, and Naohito, Hato
Subjects: Male, Sodium-Hydrogen Exchanger 1, Sodium-Hydrogen Exchangers, Immunoblotting, Transplantation, Heterologous, Mice, Nude, Immunohistochemistry, Time-Lapse Imaging, HEK293 Cells, Microscopy, Fluorescence, Cell Movement, Head and Neck Neoplasms, Cell Line, Tumor, Lymphatic Metastasis, Carcinoma, Squamous Cell, Animals, Humans, Neoplasm Invasiveness, RNA Interference, Cation Transport Proteins
Abstract: Cancer cells can migrate as collectives during invasion and/or metastasis; however, the precise molecular mechanisms of this form of migration are less clear compared with single cell migration following epithelial-mesenchymal transition. Elevated Na
Published: 2017

136. Meteor studies in the framework of the JEM-EUSO program

Author: M. Dupieux, S. Bartocci, T. Shibata, Francesco Isgrò, K. Kudela, J. N. Albert, M. Di Martino, A. Marini, S. Blin-Bondil, Frederic Jean Ronga, Mohammed Bakiri, Thomas Schanz, O. Larsson, B. Mot, Silvia Ferrarese, T. Djemil, Alberto Cellino, Livio Conti, K. Martens, G. Osteria, T. Tymieniecka, J. Sledd, G. Cordero, L. R. Wiencke, A. Zuccaro Marchi, G. Roudil, Jörn Wilms, M. Rybczyński, R. Bechini, Patrick J. Reardon, M. Haiduc, Lech Wiktor Piotrowski, Yukihiro Takahashi, José Luis Sánchez, R. Young, O. A. Saprykin, Sug Whan Kim, Y. Karadzhov, M. Nagano, Toshiki Tajima, H. Khales, B. Harlov, Carlo Vigorito, G. Sáez Cano, M. Sakata, Massimiliano Bonamente, A. Belov, T. Shirahama, Marco Casolino, G. Siemieniec-Oziȩbło, Hitoshi Ohmori, Yoshiya Kawasaki, Andreas A. Berlind, Alfonso Monaco, W. Hidber, Claudio Fornaro, Takuji Nakamura, E. Kuznetsov, F. Kanouni, Jianyi Yang, K. Benmessai, Katsuaki Asano, Yoshitaka Itow, Shigeto Watanabe, O. Martinez, J. Błȩcki, Tokonatsu Yamamoto, E. Bozzo, D. Allard, Barbara Szabelska, C. González Alvarado, J. Geary, Mikhail Panasyuk, Shinsuke Abe, Alexander Kusenko, E. M. Popescu, Hajime Yano, S. Yoshida, J. Szabelski, T. Peter, Gustavo Alonso, G. Castellini, M. E. Bertaina, M. Ave Pernas, R. Matev, J. Fujimoto, C. De Santis, Sebastián Franchini, Piotr Orleanski, H. Lim, M. D. Rodríguez Frías, N. Tajima, M. Takeda, Shigehiro Nagataki, A. Neronov, M. C. Maccarone, H. Miyamoto, Ken'ichi Nomoto, F. Dulucq, L. Santiago Crúz, M. Fouka, L. Caramete, M. Suzuki, W. Aouimeur, Amine Ahriche, M. Sanz Palomino, J. F. Valdés-Galicia, L. G. Tkachev, H. Tahi, Satoshi Wada, T. Ogawa, M. C. Talai, K. Słomińska, Markus Roth, K. Shinozaki, Angela V. Olinto, Z. Plebaniak, D. Kolev, M. Flamini, F. Bisconti, L. Mehrad, Michiyuki Chikawa, F. Tajima, A. Kedadra, S. Csorna, G. Vankova, J. Fernández-Soriano, Andrea Santangelo, Gali Garipov, Y. Takizawa, P. L. Biermann, S. Bacholle, D. Maravilla, Humberto Ibarguen Salazar, Valerie Connaughton, R. Guehaz, R. Attallah, P. Gorodetzky, Giuseppe Giraudo, T. Paul, A. Ebersoldt, S. Biktemerova, I. Dutan, Nicusor Arsene, A. Acheli, Piero Vallania, H. Tokuno, Ralph Engel, Fausto Guarino, A. Guzmán, C. Lachaud, I. Rusinov, Toshiyuki Nonaka, B. Vlcek, M. D. Sabau, L. Placidi, M. Wille, A. Sobey, Y. Uchihori, J. Hernández Carretero, A. Nardelli, H. Prieto, M. Kleifges, M. Unger, S. Dagoret-Campagne, C. De Donato, R. Cremonini, P. von Ballmoos, M. Ricci, M. Perdichizzi, Soon-Wook Kim, John N. Matthews, L. Villaseñor, H. Ikeda, Francesco Fenu, Naoto Sakaki, Yoshihiko Mizumoto, G. Masciantonio, Z. Włodarczyk, R. Tsenov, D. Monnier-Ragaigne, A. Segreto, Javier Licandro, Sergio Fernández-González, L. López Campano, Toshitaka Kajino, Belkacem Benadda, Tomás Belenguer, K. Higashide, C. Moretto, P. Galeotti, Valentina Scotti, M. Traïche, G. Medina-Tanco, Marcos Reyes, A. Pollini, Pavel Klimov, B. Panico, Takayuki Tomida, J. Bayer, J. Jochum, Graciela B. Gelmini, N. Blanc, H. Attoui, C. Tenzer, T. Sugiyama, Hajime Takami, H. J. Crawford, J. Karczmarczyk, Tadeusz Wibig, Masaki Fukushima, G. Chiritoi, J. L. Marcos, M. Mahdi, Y. Hachisu, F. Perfetto, A. Jung, F. Cafagna, G. Modestino, Y. Arai, C. de la Taille, T. Pierog, E. Joven, K. Katahira, J. Watanabe, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Pavol Bobik, D. Kang, D. Ikeda, Isabel Pérez-Grande, Johannes Eser, Y. Yamamoto, M. Rahmani, H. Lahmar, Osvaldo Catalano, B. Pastirčák, Simona Toscano, F. Sarazin, M. Serra, Luis A. Anchordoqui, T. Batsch, Jeong Sook Kim, N. Tone, Daisuke Yonetoku, Marc Weber, J. A. Morales de los Ríos, G. Abdellaoui, Pierre Barrillon, I. Kaneko, P. Baragatti, Ovidiu Vaduvescu, Santiago Pindado, B. A. Khrenov, Eduardo García-Ortega, Estíbaliz Gascón, M. Lacombe, Guillaume Prévôt, Hanna Rothkaehl, M. Yu. Zotov, R. Nava, Piergiorgio Picozza, Sergei A. Sharakin, N. Mebarki, Susumu Inoue, A. Haungs, S. Piraino, Claudio Cassardo, W. Painter, J. Rabanal, Dmitri Semikoz, B. Nadji, J. Mimouni, M. A. Mendoza, D. Campana, I. S. Zgura, Rossella Caruso, F. Lakhdari, M. Bogomilov, V. S. Morozenko, I. V. Yashin, M. Nagata, Inkyu Park, L. Marcelli, M. Putis, Y. Miyazaki, A. Weindl, Andrés Merino, A. Bruno, Yoshimasa Kurihara, J. C. Sanchez, H. Schieler, J. Lee, Antonella Castellina, Mitsuteru Sato, Mark Christl, F. Kajino, T. Jammer, O. Tibolla, Michael S. Briggs, Dmitry V. Naumov, P. Carlson, T. Mernik, T. Patzak, T. Murakami, J.N. Capdevielle, H. W. Park, Francesca Capel, S. Pliego, Thomas J. Weiler, S. Mackovjak, D. Supanitsky, R. Weigand Muñoz, Shoichi Ogio, I. Stan, K. Kawai, Akinori Saito, A. Caramete, K. S. Caballero, Hiroyuki Sagawa, A. Radu, Maxim Gonchar, Hirohiko M. Shimizu, S. A. Djenas, S. Kalli, J. Watts, C. Pennypacker, M. Vrabel, P. Prat, Z. Sahnoune, M. Karus, Domenico Finco, Roberto Bellotti, K. Mase, James H. Adams, H. Sato, Octavian Micu, E. G. Judd, Katsuhiko Tsuno, I. Kreykenbohm, Vladimir Andreev, Y. Martín, S. Ahmad, A. Anzalone, T. Napolitano, Christer Fuglesang, José Meseguer, Angel Sanz-Andrés, Y. Tsunesada, J. Genci, K. Belov, C. Catalano, M. Rezazadeh, S. Selmane, Toshikazu Ebisuzaki, S. Messaoud, Ke Fang, R. Boudaoud, Abdellaoui, G., Abe, S., Acheli, A., Adams, J. H., Ahmad, S., Ahriche, A., Albert, J. N., Allard, D., Alonso, G., Anchordoqui, L., Andreev, V., Anzalone, A., Aouimeur, W., Arai, Y., Arsene, N., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, A., Belov, K., Benadda, B., Benmessai, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin Bondil, S., Bobik, P., Bogomilov, M., Bonamente, M., Boudaoud, R., Bozzo, E., Briggs, M. S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Djenas, S. A., Dulucq, F., Dupieux, M., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fang, K., Fenu, F., Fernández González, S., Fernández Soriano, J., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujimoto, J., Fukushima, M., Galeotti, P., García Ortega, E., Garipov, G., Gascón, E., Geary, J., Gelmini, G., Genci, J., Giraudo, G., Gonchar, M., González Alvarado, C., Gorodetzky, P., Guarino, Fausto, Guehaz, R., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández Carretero, J., Hidber, W., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Isgro', Francesco, Itow, Y., Jammer, T., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kang, D., Kanouni, F., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong Sook, Kim, Soon Wook, Kim, Sug Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lim, H., López Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Martens, K., Martín, Y., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina Tanco, G., Mehrad, L., Mendoza, M. A., Merino, A., Mernik, T., Meseguer, J., Messaoud, S., Micu, O., Mimouni, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los Ríos, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nadji, B., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Nardelli, A., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perdichizzi, M., Pérez Grande, I., Perfetto, Francesco, Peter, T., Picozza, P., Pierog, T., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Putis, M., Rabanal, J., Radu, A. A., Rahmani, M., Reardon, P., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez Frías, M. D., Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Sáez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, J. C., Sánchez, J. L., Santangelo, A., Santiago Crúz, L., Sanz Andrés, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, Valentina, Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Oziȩbło, G., Sledd, J., Słomińska, K., Sobey, A., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tahi, H., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdés Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watanabe, S., Null, J. Watts J. r., Weber, M., Weigand Muñoz, R., Weindl, A., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Y. u., and Zuccaro Marchi, A.
Subjects: Physics, Meteor (satellite), Mini-EUSO, 010504 meteorology & atmospheric sciences, Meteors, JEM-EUSO, EUSO-TA, Astronomy, Nuclearites, Astronomy and Astrophysics, 01 natural sciences, Preliminary analysis, Aeronáutica, Space and Planetary Science, 0103 physical sciences, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Remote sensing
Abstract: 著者人数: 360名 (JAXA職員: 池田, 博一 ; 鈴木, 睦 ; 矢野, 創), Accepted: 2016-12-08, 資料番号: SA1170070000
Published: 2017

137. Cosmic ray oriented performance studies for the JEM-EUSO first level trigger

Author: H. Sato, T. Djemil, Alberto Cellino, Octavian Micu, Javier Licandro, M. D. Rodríguez Frías, Z. Plebaniak, N. Guardone, Katsuhiko Tsuno, A. Belov, L. R. Wiencke, N. Tone, G. Cordero, A. Anzalone, T. Napolitano, Michiyuki Chikawa, Katsuaki Asano, A. Ebersoldt, Daisuke Yonetoku, I. S. Zgura, Roberto Bellotti, M. Mahdi, T. Pierog, Yoshimasa Kurihara, H. Schieler, E. M. Popescu, Antonella Castellina, Mitsuteru Sato, T. Jammer, K. S. Caballero, Hiroyuki Sagawa, Christer Fuglesang, J. Watanabe, G. Roudil, K. Mase, Graciela B. Gelmini, G. Chiritoi, Y. Hachisu, F. Perfetto, Y. Yamamoto, B. Pastirčák, J. Geary, H. Khales, José Meseguer, Angel Sanz-Andrés, Osvaldo Catalano, Santiago Pindado, Junpei Fujimoto, B. A. Khrenov, S. Pliego, Thomas J. Weiler, Pierre Barrillon, Eduardo García-Ortega, Sergei A. Sharakin, Massimiliano Bonamente, James H. Adams, Y. Tsunesada, H. Lahmar, Patrick J. Reardon, Toshiki Tajima, G. Siemieniec-Oziȩbło, Satoshi Wada, T. Ogawa, M. Yu. Zotov, J. Genci, Piergiorgio Picozza, N. Mebarki, Mohammed Bakiri, C. Catalano, K. Benmessai, M. Suzuki, Valentina Scotti, Hitoshi Ohmori, G. Abdellaoui, Francesco Isgrò, Daisuke Ikeda, Belkacem Benadda, W. Painter, P. Gorodetzky, Yoshiya Kawasaki, E. Kuznetsov, Yoshihiko Mizumoto, R. Bechini, M. C. Talai, C. De La Taille, K. Shinozaki, A. Radu, F.J. Ronga, Alfonso Monaco, Shinsuke Abe, B. Nadji, E. Parizot, A. Guzmán, Toshitaka Kajino, K. Kawai, Ralph Engel, I. Kreykenbohm, Hajime Takami, Angela V. Olinto, Andrea Santangelo, D. Maravilla, S. Blin-Bondil, D. Allard, Vladimir Andreev, Masaki Fukushima, R. Nava, V. S. Morozenko, Akinori Saito, Maxim Gonchar, Hirohiko M. Shimizu, M. A. Mendoza, E. G. Judd, D. Kang, G. Castellini, Andreas A. Berlind, M. Rezazadeh, S. Selmane, Alexander Kusenko, K. Higashide, C. Moretto, P. Galeotti, Y. Martín, M. E. Bertaina, L. Villaseñor, C. De Santis, J. Yang, Rossella Caruso, J. Karczmarczyk, Shigeto Watanabe, Ken'ichi Nomoto, K. Słomińska, H. Attoui, C. Tenzer, F Dulucq, N. Inoue, S. Bacholle, John N. Matthews, Francesca Capel, J. F. Valdés-Galicia, L. G. Tkachev, H. Tahi, G. Vankova, Tokonatsu Yamamoto, Guillaume Prévôt, L. del Peral, A. Franceschi, Pavol Bobik, T. Sugiyama, Hajime Yano, Tadeusz Wibig, B. Mot, S. Dagoret-Campagne, S. Bartocci, E. Bozzo, M. Serra, Luis A. Anchordoqui, T. Shibata, M. Traïche, S. Mackovjak, J. Fernández-Soriano, D. Supanitsky, T. Batsch, Toshio Murakami, R. Young, M. Sakata, S. Biktemerova, Toshikazu Ebisuzaki, Yukihiro Takahashi, José Luis Sánchez, S. Ahmad, C. Lachaud, F. Cafagna, H. J. Crawford, O. Larsson, S. Messaoud, K. Kudela, G. Modestino, E. Joven, M. Rahmani, Giuseppe Giraudo, R. Weigand Muñoz, T. Shirahama, S. A. Djenas, S. Kalli, I. Kaneko, A. Haungs, S. Piraino, J. Watts, Hanna Rothkaehl, J. Mimouni, J. A. Morales de los Ríos, Toshiyuki Nonaka, Ovidiu Vaduvescu, M. Karus, L. Santiago Crúz, M. Bogomilov, Josef Jochum, F. Bisconti, M. Lacombe, Claudio Cassardo, Shoichi Ogio, M. Flamini, Silvia Ferrarese, C. Pennypacker, Marco Casolino, Claudio Fornaro, Susumu Inoue, Tomás Belenguer, J. Błȩcki, L. Mehrad, M. Vrabel, P. Prat, Piotr Orleanski, Ke Fang, Mikhail Panasyuk, F. Kajino, Andrés Merino, Y. Takizawa, M. Fouka, P. L. Biermann, Z. Sahnoune, D. Kolev, H. Lim, J. C. Sanchez, Maciej Rybczyński, G. Sáez Cano, D. Monnier-Ragaigne, A. Segreto, W. Aouimeur, A. Neronov, M. C. Maccarone, B. Harlov, I. Rusinov, P. Carlson, T. Mernik, A. Jung, H. W. Park, R. Boudaoud, M. Dupieux, I. V. Yashin, Carlo Vigorito, Domenico Finco, A. Kedadra, T. Paul, Valerie Connaughton, Marcos Reyes, R. Guehaz, N. Blanc, M. Ave Pernas, T. Nakamura, Yoshio Arai, L. Marcelli, I. Dutan, L. Placidi, A. Sobey, Francesco Fenu, Piero Vallania, S. E. Csorna, G. Masciantonio, G. Medina-Tanco, J. L. Marcos, M. D. Sabau, Johannes Eser, H. Prieto, R. Cremonini, H. Ikeda, Naoto Sakaki, G. Cotto, Markus Roth, C. De Donato, L. López Campano, Sergio Fernández-González, Takayuki Tomida, Nicusor Arsene, J. Bayer, A. Insolia, M. Kleifges, N. Tajima, M. Takeda, Soon-Wook Kim, J. Rabanal, J. Hernández Carretero, Fausto Guarino, P. von Ballmoos, M. Ricci, A. Bruno, M. Unger, Shigehiro Nagataki, K. Katahira, Isabel Pérez-Grande, F. Sarazin, Zbigniew Wlodarczyk, Marc Weber, R. Matev, Simona Toscano, Michael S. Briggs, M. Haiduc, Lech Wiktor Piotrowski, S. Yoshida, J. Szabelski, Estíbaliz Gascón, O. Martinez, T. Patzak, M. Nagata, Dmitry V. Naumov, J.N. Capdevielle, I. Stan, A. Caramete, K. Martens, Konstantin Belov, Joowon Lee, F. Tajima, A. Acheli, J. N. Albert, Thomas Schanz, M. Wille, Livio Conti, Y. Uchihori, A. Zuccaro Marchi, Jörn Wilms, O. A. Saprykin, Sug Whan Kim, F. Kanouni, Sebastián Franchini, Gali Garipov, R. Attallah, D. Campana, F. Lakhdari, Barbara Szabelska, Inkyu Park, M. Putis, Y. Miyazaki, A. Weindl, T. Peter, B. Vlcek, Mark Christl, Gustavo Alonso, O. Tibolla, Jeong Sook Kim, C. González Alvarado, P. Baragatti, H. Miyamoto, M. Manfrin, Yoshitaka Itow, L. Caramete, M. Sanz Palomino, Y. Karadzhov, Amine Ahriche, Humberto Ibarguen Salazar, G. Contino, H. Tokuno, W. Hidber, R. Tsenov, R. Forza, A. Pollini, Pavel Klimov, B. Panico, M. Mignone, M. Di Martino, A. Marini, G. Osteria, D.V. Semikoz, T. Tymieniecka, J. Sledd, M. Nagano, Abdellaoui, G., Abe, S., Acheli, A., Adams, J. H., Ahmad, S., Ahriche, A., Albert, J. N., Allard, D., Alonso, G., Anchordoqui, L., Andreev, V., Anzalone, A., Aouimeur, W., Arai, Y., Arsene, N., Asano, K., Attallah, R., Attoui, H., Ave pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, A., Belov, K., Benadda, B., Benmessai, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin Bondil, S., Bobik, P., Bogomilov, M., Bonamente, M., Boudaoud, R., Bozzo, E., Briggs, M. S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Contino, G., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., De donato, C., De la taille, C., De santis, C., Del peral, L., Di martino, M., Djemil, T., Djenas, S. A., Dulucq, F., Dupieux, M., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fang, K., Fenu, F., Fernández González, S., Fernández Soriano, J., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Forza, R., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujimoto, J., Fukushima, M., Galeotti, P., García Ortega, E., Garipov, G., Gascón, E., Geary, J., Gelmini, G., Genci, J., Giraudo, G., Gonchar, M., González alvarado, C., Gorodetzky, P., Guardone, N., Guarino, Fausto, Guehaz, R., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández carretero, J., Hidber, W., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro', Francesco, Itow, Y., Jammer, T., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kang, D., Kanouni, F., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong Sook, Kim, Soon Wook, Kim, Sug Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lim, H., López campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Manfrin, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Martens, K., Martín, Y., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina Tanco, G., Mehrad, L., Mendoza, M. A., Merino, A., Mernik, T., Meseguer, J., Messaoud, S., Micu, O., Mignone, M., Mimouni, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los ríos, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nadji, B., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Pérez Grande, I., Perfetto, Francesco, Peter, T., Picozza, P., Pierog, T., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Putis, M., Rabanal, J., Radu, A. A., Rahmani, M., Reardon, P., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez frías, M. D., Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Sáez cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, J. C., Sánchez, J. L., Santangelo, A., Santiago crúz, L., Sanz Andrés, A., Sanz palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, Valentina, Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Oziȩbło, G., Sledd, J., Słomińska, K., Sobey, A., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tahi, H., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdés Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., Von ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weigand muñoz, R., Weindl, A., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Y. u., Zuccaro marchi, A., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Nuclear and High Energy Physics, data analysis method, Instrumentation, Astrophysics::High Energy Astrophysical Phenomena, Night sky, measurement methods, satellite, JEM-EUSO, FPGA, Nightglow background, Trigger system, Cosmic ray, 01 natural sciences, law.invention, Aeronáutica, Telescope, nightglow background, law, 0103 physical sciences, International Space Station, cosmic radiation: UHE, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, background: suppression, Remote sensing, Physics, detector: wide-angle, trigger system, laser: pulsed, showers: atmosphere, 010308 nuclear & particles physics, Astrophysics::Instrumentation and Methods for Astrophysics, trigger, Astronomía, Satellite, background: fluctuation, FPGA, JEM-EUSO, Nightglow background, Trigger system, Nuclear and High Energy Physics, Instrumentation, Neutrino, Energy (signal processing), performance
Abstract: 著者人数: 368名 (JAXA職員: 池田, 博一 ; 鈴木, 睦 ; 矢野, 創), Accepted: 2017-05-29, 資料番号: SA1170117000
Published: 2017

138. Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy

Author: Hisaaki Takahashi, Mitsumasa Fukuda, Yusuke Izumo-Shimizu, Eiichi Ishii, Shinji Tsuda, Kenta Fujiyama, Kouhei Yoshimoto, Masanori Ito, Yoshiaki Yano, Junya Tanaka, Hajime Yano, and Ryota Motoie
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Article Subject, medicine.medical_treatment, Encephalopathy, Hypoxic Ischemic Encephalopathy, Cerebral edema, Lesion, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, medicine, Saline, Survival rate, business.industry, lcsh:Other systems of medicine, medicine.disease, lcsh:RZ201-999, 030104 developmental biology, Aquaporin 4, Complementary and alternative medicine, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article
Abstract: Secondary cerebral edema regulation is of prognostic significance in hypoxic-ischemic encephalopathy (HIE), and aquaporin 4 (AQP4) plays an important role in the pathogenesis of cerebral edema. The traditional Japanese herbal medicine Goreisan relieves brain edema in adults; however, its effect and pharmacological mechanism in children are unknown. We investigated the effects of Goreisan on HIE-associated brain edema and AQP4 expression in a juvenile rat model, established by combined occlusion of middle cerebral and common carotid arteries. Magnetic resonance imaging showed that the lesion areas were significantly smaller in the Goreisan- (2 g/kg) treated group than in the nontreated (saline) group at 24 and 48 h postoperatively. AQP4 mRNA levels in the lesion and nonlesion sides were significantly suppressed in the Goreisan group compared with the nontreated group 36 h postoperatively. Western blotting revealed that levels of AQP4 protein were significantly decreased in the Goreisan group compared with the nontreated group in the lesion side 72 h postoperatively, but not at 12 or 36 h. After 14 days, the Goreisan group had a significantly better survival rate. These findings suggest that Goreisan suppresses brain edema in HIE and improves survival in juvenile rats, possibly via regulation of AQP4 expression and function.
Published: 2017

139. Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma

Author: Yuya Kawabe, Hironobu Harada, Hajime Yano, Kana Sugimoto, Yuki Hosokawa, Hisaaki Takahashi, Shinji Iwata, Akihiro Inoue, Daisuke Yamashita, Junya Tanaka, Takanori Ohnishi, Shiro Ohue, and Shohei Kohno
Subjects: Vascular Endothelial Growth Factor A, Cancer Research, Pathology, medicine.medical_specialty, Angiogenesis, Gene Expression, Mice, Nude, Biology, Neovascularization, chemistry.chemical_compound, Downregulation and upregulation, Tumor Cells, Cultured, medicine, Animals, Humans, Protein kinase B, Tube formation, Neovascularization, Pathologic, Brain Neoplasms, General Medicine, Hypoxia-Inducible Factor 1, alpha Subunit, Oncogene Protein v-akt, Vascular endothelial growth factor, Vascular endothelial growth factor A, Oncology, chemistry, sense organs, Neurology (clinical), medicine.symptom, Stem cell, Glioblastoma, Octamer Transcription Factor-3, Neoplasm Transplantation
Abstract: Accumulating evidence shows that the expression level of Oct-3/4, a self-renewal regulator in stem cells, is positively correlated with the progression of various solid tumors. However, little is known regarding the influence of Oct-3/4 in the tumor angiogenesis of glioblastomas. In the present study, we subcutaneously transplanted Oct-3/4-overexpressing human glioblastoma U251 (U251/EGFP-Oct-3/4) cells into the right thighs of nude mice to evaluate the roles of Oct-3/4 in the tumor angiogenesis. Both tumor size and the number of large vessels growing in the tumor were markedly increased. In an in vitro model of angiogenesis, the conditioned media from U251/EGFP-Oct-3/4 cells significantly accelerated capillary-like tube formation compared with that of U251/EGFP cells. In comparison with U251/EGFP cells, U251/EGFP-Oct-3/4 cells had markedly elevated the expression of vascular endothelial growth factor mRNA under the control of hypoxia-inducible factor (HIF) 1α. In U251/EGFP-Oct-3/4 cells, enhanced protein expression and nuclear translocation of HIF1α were observed. Furthermore, we demonstrated that the involvement of AKT, an oncogenic signaling molecule, in the Oct-3/4 induced upregulation of HIF1α protein. Our findings suggest that Oct-3/4-expressing glioblastoma cells have the ability to adapt to low-oxygen environments within tumor masses by promoting tumor angiogenesis through AKT-HIF1 pathway.
Published: 2014

140. Microparticle impact calibration of the Arrayed Large-Area Dust Detectors in INterplanetary space (ALADDIN) onboard the solar power sail demonstrator IKAROS

Author: Ralf Srama, Sunao Hasegawa, Hajime Yano, Masanori Kobayashi, Masayuki Fujii, Mike J. Cole, Takeo Iwai, and Takayuki Hirai
Subjects: Physics, Zodiacal light, business.industry, PVDF, Astronomy and Astrophysics, Microparticle impact calibration, Radiation, Laser, law.invention, In-situ dust detector, Interplanetary dust cloud, Optics, Space and Planetary Science, law, Hypervelocity, Van de Graaff generator, Interplanetary spaceflight, business, Cosmic dust
Abstract: Accepted: 2014-05-12, 資料番号: SA1140138000
Published: 2014

141. Planetary protection on international waters: An onboard protocol for capsule retrieval and biosafety control in sample return mission

Author: Yasuhito Sekine, Hajime Yano, Ryu Funase, Yoshinori Takano, and Ken Takai
Subjects: Atmospheric Science, Jurisdiction, Planetary protection, business.industry, Onboard protocols, Environmental resource management, Extraterrestrial materials, Aerospace Engineering, Astronomy and Astrophysics, Sample (statistics), International waters, Ongoing chemical evolution, Unexplored biosphere, Biosafety, Geophysics, Sample return mission, Space and Planetary Science, General Earth and Planetary Sciences, Environmental science, business, Outer Space Treaty, Remote sensing
Abstract: Accepted: 2013-12-28, 資料番号: SA1140011000
Published: 2014
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142. JEM-EUSO observational technique and exposure

Author: G. Castellinic, Markus Roth, Thomas J. Weiler, S. Perez Cano, Fausto Guarino, P. von Ballmoos, M. Ricci, Roberto Bellotti, Andreas A. Berlind, K. Kawai, M. Di Martino, A. Marini, Graciela B. Gelmini, Akinori Saito, G. Osteria, T. Tymieniecka, Barbara Szabelska, T. Peter, J. Sledd, Y. Hachisu, Y. Arai, P. L. Biermann, Ovidiu Vaduvescu, M. Lacombe, Claudio Cassardo, M. Nagata, James H. Adams, J. Fujimoto, Dmitri Semikoz, O. Martinez, Dmitry V. Naumov, Y. Yamamoto, M. I. Panasyuk, I. V. Yashin, L. Marcelli, J.N. Capdevielle, H. Ikeda, Andrii Neronov, D. Kolev, Silvia Ferrarese, I. Rusinov, T. Mernik, Gali Garipov, Yoshihiko Mizumoto, Katsuaki Asano, Guillaume Prévôt, Kenji Shinozaki, A. Bruno, H. Sato, Pierre Barrillon, Valerie Connaughton, H. H. Silva Lopez, T. Batsch, T. Shibata, S. Selmane, T. Murakami, J. Karczmarczyk, Karl Mannheim, Michael S. Briggs, A. J. de Castro, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, M. Bogomilov, Pavol Bobik, Y. Karadzhov, Yoshitaka Itow, G. Distratis, Marcos Reyes, Sergei A. Sharakin, R. Young, M. Sakata, A. Anzalone, N. Tajima, T. Napolitano, David B. Cline, T. Patzak, Piero Vallania, Hanna Rothkaehl, S. Blin-Bondil, M. D. Sabau, Satoshi Wada, T. Ogawa, F. Kajino, Shigehiro Nagataki, M. Serra, F. Cafagna, G. Modestino, Luis A. Anchordoqui, E. G. Judd, Katsuhiko Tsuno, H. W. Park, J. A. Morales de los Ríos, F. Tajima, E. Joven, Massimiliano Bonamente, R. Bechini, Ralph Engel, J. Watts, K. Belov, P. Gorodetzky, Humberto Ibarguen Salazar, C. Catalano, J. Lee, C. Lachaud, S. Dagoret-Campagne, Tomás Belenguer, B. A. Khrenov, Angela V. Olinto, Fernando López, Andrea Santangelo, C. De Santis, H. Tokuno, H. Miyamoto, E. Kuznetsov, C. Pennypacker, Piergiorgio Picozza, Toshikazu Ebisuzaki, L. Santiago Crúz, J. Bayer, M. Wille, I. Kreykenbohm, Vladimir Andreev, B. Pastircak, S. Sánchez, M. Ave Pernas, Alexander Kusenko, J. Błȩcki, M. Nagano Murakami, Frederic Trillaud, Y. Uchihori, Susumu Inoue, J. N. Albert, C. Blaksley, I. Kaneko, Toshiyuki Nonaka, P. Prat, K. Słomińska, C. de la Taille, Alfonso Monaco, Thomas Schanz, Shigeto Watanabe, Ke Fang, I. Fernández-Gómez, H. Prieto, R. Cremonini, B. Mot, R. Tsenov, K. Katahira, S. Ahmad, Livio Conti, N. Tone, Z. Włodarczyk, H. Lim, M. C. Maccarone, J. F. Valdés-Galicia, L. G. Tkachev, M. Dupieux, F. Dulucq, A. Pollini, Pavel Klimov, Patrick J. Reardon, Toshiki Tajima, A. Zuccaro Marchi, M. Karus, D. Monnier-Ragaigne, A. Segreto, Daisuke Yonetoku, S. Csorna, G. Vankova, H. J. Crawford, Taka Tomida, Jörn Wilms, Yukihiro Takahashi, G. Siemieniec-Oziȩbło, Yoshimasa Kurihara, O. A. Saprykin, A. Dell’Oro, Toshitaka Kajino, H. Schieler, N. Blanc, G. Masciantonio, Hitoshi Ohmori, Domenico Finco, J. Hernández Carretero, D. Supanitsky, M. Yu. Zotov, M. Unger, S. Biktemerova, Yoshiya Kawasaki, K. Higashide, C. Moretto, Tokonatsu Yamamoto, P. Galeotti, Susana Briz, G. Catalano, Hiroyuki Sagawa, C. González Alvarado, Mitsuteru Sato, Shoichi Ogio, C. Tenzer, Marco Casolino, Claudio Fornaro, M. Putis, D. Allard, A. Guzmán, A. Sobey, M. E. Bertaina, D. Campana, C. De Donato, A. Insolia, M. Kleifges, Soon-Wook Kim, Ken'ichi Nomoto, T. Sugiyama, A. Ebersoldt, Tadeusz Wibig, M. Sanz Palomino, Maxim Gonchar, Inkyu Park, Hirohiko M. Shimizu, J. Geary, S. Falk, A. Haungs, S. Piraino, Hajime Yano, N. De Simone, Y. Miyazaki, G. Roudil, L. Villaseñor, M. Suzuki, B. Harlov, Carlo Vigorito, K. Kudela, J. S. Kim, G. Sáez-Cano, Mark Christl, O. Tibolla, V. S. Morozenko, Yoshiki Tsunesada, M. Rybczyński, Lech Wiktor Piotrowski, A. Jung, T. Paul, K. Yoshida, P. Baragatti, G. Cordero, Valentina Scotti, Hajime Takami, Masaki Fukushima, G. Medina-Tanco, S. Yoshida, J. Szabelski, T. Nakamura, R. Nava, N. Sakaki, R. Matev, M. D. Rodríguez Frías, Z. Plebaniak, J. Blümer, L. Valore, Rossella Caruso, Michiyuki Chikawa, Simona Toscano, Alberto Cellino, L. R. Wiencke, K. Mase, G. Giraudo, Francesco Fenu, D. Ikeda, I. Rodríguez, F. Sarazin, Marc Weber, M. Flamini, Y. Takizawa, T. Shirahama, Francesco Isgrò, Piotr Orleanski, B. Keilhauer, Frederic Jean Ronga, Javier Licandro, T. Pierog, J. Watanabe, M. Takeda, D. Maravilla, Jianyi Yang, Adams, J. H., Ahmad, S., Albert, J. N., Allard, D., Anchordoqui, L., Andreev, V., Anzalone, A., Arai, Y., Asano, K., Ave Pernas, M., Baragatti, P., Barrillon, P., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blanc, N., Błȩcki, J., Blin Bondil, S., Blümer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J. N., Caruso, R., Casolino, M., Cassardo, C., Castellinic, G., Catalano, C., Catalano, G., Cellino, A., Chikawa, M., Christl, M. J., Cline, D., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Dell’Oro, A., De Simone, N., Di Martino, M., Distratis, G., Dulucq, F., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernández Gómez, I., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Franceschi, A., Fujimoto, J., Fukushima, M., Galeotti, P., Garipov, G., Geary, J., Gelmini, G., Giraudo, G., Gonchar, M., González Alvarado, C., Gorodetzky, P., Guarino, Fausto, Guzmán, A., Hachisu, Y., Harlov, B., Haungs, A., Hernández Carretero, J., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro', Francesco, Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Kim, J. S., Kim, S. W., Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lee, J., Licandro, J., Lim, H., López, F., Maccarone, M. C., Mannheim, K., Maravilla, D., Marcelli, L., Marini, A., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Medina Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los Ríos, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Murakami, M. Nagano, Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Panasyuk, M. I., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perez Cano, S., Peter, T., Picozza, P., Pierog, T., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Prat, P., Prévôt, G., Prieto, H., Putis, M., Reardon, P., Reyes, M., Ricci, M., Rodríguez, I., Rodríguez Frías, M. D., Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Sáez Cano, G., Sagawa, H., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sánchez, S., Santangelo, A., Santiago Crúz, L., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Oziȩbło, G., Silva López, H. H., Sledd, J., Słomińska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Trillaud, F., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdés Galicia, J. F., Vallania, P., Valore, Laura, Vankova, G., Vigorito, C., Villaseñor, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zotov, M. Y. u., and Zuccaro Marchi, A.
Subjects: Aperture, Ciencias Físicas, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Extensive air shower, JEM-EUSO, ultra-high energy cosmic rays, Cosmic ray, Astrophysics, Atmosphere, Altitude, International Space Station, Nadir, Extensive air showers, extensive air showers, Ultra-high energy cosmic ray, Physics::Atmospheric and Oceanic Physics, media_common, Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Ultra-high energy cosmic rays, Astronomy and Astrophysic, Universe, Astronomía, Tilt (optics), Space and Planetary Science, Physics::Space Physics, Astrophysics::Earth and Planetary Astrophysics, CIENCIAS NATURALES Y EXACTAS
Abstract: Designed as the first mission to explore the ultra-high energy universe from space, JEM-EUSO observes the Earth’s atmosphere at night to record the ultraviolet tracks generated by the extensive air showers. We present the expected geometrical aperture and annual exposure in the nadir and tilt modes for ultra-high energy cosmic rays observation as a function of the altitude of the International Space Station. Fil: Bertaina, M.. Istituto Nazionale di Fisica Nucleare; Italia Fil: Bobik, P.. Institute of Experimental Physics; Eslovaquia Fil: Fenu, F.. University of Tubingen; Alemania Fil: Shinozaki, K.. RIKEN; Japón Fil: Adams, J. H.. University of Alabama in Huntsville; Estados Unidos Fil: Ahmad, S.. Ecole Polytechnique; Francia Fil: Albert, J. N.. Univ Paris-Sud; Francia Fil: Allard, D.. Univ Paris Diderot; Francia Fil: Anchordoqui, L.. University of Wisconsin-Milwaukee; Estados Unidos Fil: Andreev, V.. University of California; Estados Unidos Fil: Anzalone, A.. Istituto di Astrofisica Spaziale e Fisica Cosmica di Palermo; Italia Fil: Arai, Y.. High Energy Accelerator Research Organization (KEK); Japón Fil: Asano, K.. Tokyo Institute of Technology; Japón Fil: Ave Pernas, M.. Universidad de Alcalá; España Fil: Baragatti, P.. UTIU, Dipartimento di Ingegneria; Italia Fil: Barrillon, P.. Univ Paris-Sud; Francia Fil: Batsch, T.. National Centre for Nuclear Research; Polonia Fil: Bayer, J.. University of Tubingen; Alemania Fil: Bechini, R.. Istituto Nazionale di Fisica Nucleare; Italia Fil: Belenguer, T.. Instituto Nacional de Tecnica Aeroespacial (INTA); España Fil: Bellotti, R.. Istituto Nazionale di Fisica Nucleare; Italia Fil: Belov, K.. University of California; Estados Unidos Fil: Berlind, A. A.. Vanderbilt University; Estados Unidos Fil: Biermann, P. L.. Karlsruhe Institute of Technology (KIT); Alemania Fil: Biktemerova, S.. Joint Institute for Nuclear Research; Rusia Fil: Blaksley, C.. Univ Paris Diderot; Francia Fil: Blanc, N.. Swiss Center for Electronics and Microtechnology (CSEM); Suiza Fil: Blecki, J.. Space Research Centre of the Polish Academy of Sciences (CBK); Polonia Fil: Supanitsky, Alberto Daniel. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentina Fil: The JEM-EUSO Collaboration.
Published: 2014

143. Fluorescence Imaging of Microbe-Containing Particles Shot from a Two-Stage Light-Gas Gun into an Aerogel

Author: Akihiko Yamagishi, Sunao Hasegawa, Eichi Imai, K. Okudaira, Yuko Kawaguchi, Tomohiro Sugino, Hideyuki Kawai, Shin-ichi Yokobori, Kensei Kobayashi, Hikaru Yabuta, Makoto Tabata, Hirofumi Hashimoto, Hajime Mita, and Hajime Yano
Subjects: DNA, Bacterial, Fluorescence-lifetime imaging microscopy, Microscope, Materials science, Extraterrestrial Environment, Diamines, law.invention, Hypervelocity impact experiment, Optics, law, Light-gas gun, Fluorescence microscope, DNA-specific fluorescence dye, Benzothiazoles, Organic Chemicals, Particle Size, Ecology, Evolution, Behavior and Systematics, Aerogel, business.industry, General Medicine, Space experiment, Silicon Dioxide, Fluorescence, Spectrometry, Fluorescence, Space and Planetary Science, Quinolines, Particle, Deinococcus, Particle size, business, Gels
Abstract: 著者人数: 14名, Accepted: 2014-06-26, 資料番号: SA1140068000
Published: 2014

144. Temperature Measurement of Space Environment with Tanpopo Space Thermometer

Author: Shin-ichi Yokobori, Eiichi Imai, Hirofumi Hashimoto, Hajime Yano, and Akihiko Yamagishi
Subjects: Physics, business.industry, Thermometer, Aerospace engineering, business, Space (mathematics), Temperature measurement, Space environment
Published: 2019

145. Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1

Author: Hajime Yano, Ryutaro Nishioka, Kana Sugimoto, Yoshiaki Kumon, Airi Ikeda, Ayano Mise, Hisaaki Takahashi, Takanori Ohnishi, and Junya Tanaka
Subjects: NG2 proteoglycan, Pathology, medicine.medical_specialty, Neurofilament, biology, Microglia, Neurodegeneration, medicine.disease, Cell biology, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine.anatomical_structure, nervous system, Neurology, chemistry, Chondroitin sulfate proteoglycan, biology.protein, medicine, NeuN, Receptor, Transforming growth factor
Abstract: We investigated activated microglia in ischemic brain lesions from rats that had been subjected to transient middle cerebral artery occlusion. Activated microglia expressing NG2 chondroitin sulfate proteoglycan (NG2) were found only in the narrow zone (demarcation zone) that demarcated the peri-infarct tissue and ischemic core. NG2(-) activated microglia were abundantly distributed in the peri-infarct tissue outside the demarcation zone. NG2(+) microglia but not NG2(-) microglia expressed both CD68 and a triggering receptor expressed on myeloid cells 2 (TREM-2), suggesting that NG2(+) microglia eliminated apoptotic neurons. In fact, NG2(+) microglia often attached to degenerating neurons and sometimes internalized NeuN(+) or neurofilament protein(+) material. Kinetic studies using quantitative real-time RT-PCR revealed that expression of transforming growth factor-β1 (TGF-β1) was most evident in the ischemic core; with this marker produced mainly by macrophages located in this region. TGF-β receptor mRNA expression peaked at 3 days post reperfusion (dpr) in the peri-infarct tissue, including the demarcation zone. Primary cultured rat microglia also expressed the receptor mRNA. In response to TGF-β1, primary microglia enhanced the expression of NG2 protein and TREM-2 mRNA as well as migratory activity. A TGF-β1 inhibitor, SB525334, abolished these effects. The present results suggest that TGF-β1 produced in the ischemic core diffused toward the peri-infarct tissue, driving activated microglial cells to eliminate degenerating neurons. Appropriate control of NG2(+) microglia in the demarcation zone might be a novel target for the suppression of secondary neurodegeneration in the peri-infarct tissue.
Published: 2013

146. Development of On-board Image Processing Algorithm to Detect Lunar Impact Flashes for DELPHINUS.

Author: Masahiro FUJIWARA, Satoshi IKARI, Hirotaka KONDO, Ryota FUSE, Yosuke MASUDA, Shinsuke ABE, Masahisa YANAGISAWA, Kenji YAMAMOTO, Hajime YANO, and Ryu FUNASE
Subjects: IMAGE processing, ALGORITHMS, OBSERVATIONS of the Moon, LUNAR surface, PIXELS
Abstract: DELPHINUS is a camera system mounted on EQUULEUS, which is planned to be launched using NASA's Space Launch System EM-1 in 2021. DELPHINUS aims to investigate size distribution, influx ratio, and daily variation of meteoroids in the cislunar space through observations of lunar impact flashes (LIFs) from the far side of the moon. DELPHINUS will observe the moon's surface with the 60-fps camera modules to capture the flashes that are short duration phenomena. All image data cannot be downlinked due to constraints in memory size and communication capability. Therefore, an on-board image processing algorithm was developed to reduce downlinked data size by extracting only necessary pixel data including LIFs. Three experiments using three simulators were demonstrated to verify the real-time processing performance and detection capability. This paper reports the details of the proposed algorithm and the verification results. [ABSTRACT FROM AUTHOR]
Published: 2020
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147. Erratum to: Ultra high energy photons and neutrinos with JEM-EUSO

Author: S. Perez Cano, M. Bogomilov, M. Rybczyński, P. Gorodetzky, G. Cordero, K. Kawai, O. Martinez, Akinori Saito, Francesco Fenu, Y. Itow, Lech Wiktor Piotrowski, R. Matev, Toshikazu Ebisuzaki, J. N. Capdevielle, L. Santiago Crúz, Hiroyuki Sagawa, D. Ikeda, Ovidiu Vaduvescu, M. Lacombe, Claudio Cassardo, S. Yoshida, F. Guarino, Silvia Ferrarese, V. Scotti, T. Nonaka, A. Haungs, H. Schieler, I. Kreykenbohm, Y. Hachisu, T. Batsch, Y. Arai, E. Kuznetsov, T. J. Weiler, M. S. Briggs, Y. Tsunesada, R. Bechini, P. Picozza, Tomás Belenguer, M. Bonamente, M. Roth, N. Inoue, H. Salazar, M. Ave Pernas, L. Wiencke, C. de la Taille, K. Katahira, I. Fernández-Gómez, F. Cafagna, J. Licandro, K. Higashide, S. Ahmad, M. Unger, Maxim Gonchar, T. Tomida, M. I. Panasyuk, Ke Fang, M. Sakata, M. Reyes, L. Marcelli, J. Yang, D. Cline, H. Takami, R. Young, V. Connaughton, H. J. Crawford, L. del Peral, A. Franceschi, E. Parizot, A. Kusenko, P. Reardon, Hajime Yano, M. Di Martino, J. Hernández Carretero, A. Marini, M. Kleifges, D. Supanitsky, G. Siemieniec-Oziȩbło, M. Dupieux, Sergei A. Sharakin, Roberto Bellotti, G. Castellinic, J. Błȩcki, T. Paul, F. Dulucq, J. A. Morales de los Ríos, M. Chikawa, P. Vallania, Y. Karadzhov, S. Sánchez, G. Distratis, D. Allard, T. Tymieniecka, J. Sledd, M. Nagata, C. González Alvarado, M. Flamini, P. von Ballmoos, M. E. Bertaina, H. Lim, Dmitry V. Naumov, M. C. Maccarone, S. Selmane, G. Sáez-Cano, H. Ohmori, S. W. Kim, G. Medina-Tanco, G. Modestino, Y. Takizawa, C. Blaksley, H. Sato, A. Guzman, Susumu Inoue, T. Shibata, N. Tone, J. Watts, M. Suzuki, C. Pennypacker, T. Murakami, E. Joven, B. Pastircak, J. F. Valdés-Galicia, L. Tkachev, S. Csorna, J. Watanabe, M. Wille, R. Cremonini, J. Szabelski, Y. Mizumoto, P. Prat, J. Karczmarczyk, M. D. Sabau, M. Sanz Palomino, Y. Miyazaki, M. Putis, A. Sobey, Satoshi Wada, M. Takeda, T. Ogawa, H. H. Silva Lopez, M. Yu. Zotov, E. G. Judd, S. Piraino, A. Jung, G. Vankova, A. Cellino, K. Shinozaki, R. Nava, J. H. Adams, N. Sakaki, Gali Garipov, T. Napolitano, T. Mernik, Susana Briz, M. Karus, Angela V. Olinto, Fernando López, Andrea Santangelo, K. Yoshida, K. Mase, O. Tibolla, Rossella Caruso, L. Anchordoqui, P. Barrillon, S. Nagataki, J. Blümer, T. Shirahama, Domenico Finco, T. Patzak, D. Campana, J. Lee, K. Nomoto, C. Lachaud, S. Dagoret-Campagne, F. Tajima, C. Moretto, H. Prieto, P. L. Biermann, A. Anzalone, C. De Donato, T. Yamamoto, R. Engel, P. Baragatti, J. N. Albert, I. Rusinov, K. Belov, Thomas Schanz, J. S. Kim, V. S. Morozenko, Livio Conti, C. De Santis, A. Zuccaro Marchi, A. A. Berlind, M. Nagano Murakami, Mitsuteru Sato, F. Sarazin, Jörn Wilms, O. A. Saprykin, T. Tajima, H. M. Shimizu, J. Bayer, J. Geary, A. Pollini, Pavel Klimov, N. De Simone, T. Peter, N. Tajima, Y. Yamamoto, A. Dell’Oro, H. Tokuno, T. Sugiyama, G. Roudil, B. Harlov, Carlo Vigorito, K. Kudela, M. Weber, D. Monnier-Ragaigne, A. Segreto, H. Rothkaehl, C. Catalano, N. Blanc, C. Tenzer, D. Semikoz, I. H. Park, J. Fujimoto, G. Giraudo, T. Kajino, F. Ronga, G. Osteria, P. Bobik, S. Biktemerova, Francesco Isgrò, G. Prévôt, K. Tsuno, T. Pierog, S. Blin-Bondil, V. Andreev, D. Yonetoku, T. Wibig, K. Asano, B. A. Khrenov, H. Miyamoto, K. Słomińska, M. Ricci, A. Neronov, Z. Włodarczyk, P. Galeotti, D. Kolev, G. Gelmini, Simona Toscano, I. V. Yashin, S. Watanabe, R. Tsenov, I. Rodríguez, P. Orleański, G. Masciantonio, A. J. de Castro, M. Fukushima, Z. Plebaniak, A. Insolia, F. Kajino, L. Valore, B. Keilhauer, H. W. Park, A. Bruno, Y. Uchihori, K. Mannheim, Frederic Trillaud, B. Mot, Yukihiro Takahashi, Alfonso Monaco, Marco Casolino, Claudio Fornaro, G. Catalano, Y. Kawasaki, S. Falk, S. Ogio, H. Ikeda, A. Ebersoldt, L. Villaseñor, Y. Kurihara, D. Maravilla, T. Nakamura, M. Serra, I. Kaneko, B. Szabelska, M. J. Christl, and M. D. Rodríguez Frías
Subjects: Physics, High energy photon, Space and Planetary Science, Astrophysics::High Energy Astrophysical Phenomena, Physics::Space Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, High Energy Physics::Experiment, Astronomy and Astrophysics, Neutrino, Neutrinos Photons Space observation
Abstract: Ultra high energy photons and neutrinos are carriers of very important astrophysical information. They may be produced at the sites of cosmic ray acceleration or during the propagation of the cosmic rays in the intergalactic medium. In contrast to charged cosmic rays, photon and neutrino arrival directions point to the production site because they are not deflected by the magnetic fields of the Galaxy or the intergalactic medium. In this work we study the characteristics of the longitudinal development of showers initiated by photons and neutrinos at the highest energies. These studies are relevant for development of techniques for neutrino and photon identification by the JEM-EUSO telescope. In particular, we study the possibility of observing the multi-peak structure of very deep horizontal neutrino showers with JEM-EUSO. We also discuss the possibility to determine the flavor content of the incident neutrino flux by taking advantage of the different characteristics of the longitudinal profiles generated by different type of neutrinos. This is of grate importance for the study of the fundamental properties of neutrinos at the highest energies. Regarding photons, we discuss the detectability of the cosmogenic component by JEM-EUSO and also estimate the expected upper limits on the photon fraction which can be obtained from the future JEM-EUSO data for the case in which there are no photons in the samples.
Published: 2015

148. Erratum to: Performances of JEM-EUSO: angular reconstruction

Author: H. Sato, A. Guzman, David B. Cline, E. G. Judd, Katsuhiko Tsuno, I. Rodríguez, Roberto Bellotti, James H. Adams, I. Kreykenbohm, M. Ave Pernas, Vladimir Andreev, K. Mase, R. Young, M. Sakata, N. Tone, S. Ahmad, Massimiliano Bonamente, Ovidiu Vaduvescu, Yoshihiko Mizumoto, Katsuaki Asano, Toshikazu Ebisuzaki, T. Shirahama, C. González Alvarado, Francesco Fenu, M. Lacombe, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, F. Tajima, E. Kuznetsov, Andreas A. Berlind, Daisuke Yonetoku, Claudio Cassardo, Graciela B. Gelmini, J. N. Capdevielle, L. Santiago Crúz, M. Wille, M. Nagano Murakami, Y. Uchihori, Alexander Kusenko, J. Hernández Carretero, B. Mot, M. Di Martino, A. Marini, Y. Hachisu, G. Osteria, Satoshi Wada, T. Ogawa, Silvia Ferrarese, Francesco Isgrò, F. Dulucq, T. Tymieniecka, J. Błȩcki, H. Prieto, H. Lim, M. C. Maccarone, M. Sanz Palomino, Y. Arai, N. Tajima, T. Murakami, J. Sledd, Shigehiro Nagataki, D. Kolev, H. Ikeda, R. Cremonini, B. Keilhauer, G. Prévôt, J. A. Morales de los Ríos, J. Karczmarczyk, Yukihiro Takahashi, J. Watts, M. Unger, M. Yu. Zotov, Susana Briz, J. N. Albert, Ke Fang, Thomas Schanz, K. Słomińska, C. Pennypacker, B. Pastircak, Barbara Szabelska, T. Peter, Susumu Inoue, Piotr Orleanski, Frederic Jean Ronga, D. Ikeda, Livio Conti, Y. Yamamoto, A. Zuccaro Marchi, Valerie Connaughton, H. H. Silva Lopez, G. Distratis, Angela V. Olinto, Fernando López, Andrea Santangelo, Jörn Wilms, O. A. Saprykin, M. Nagata, Marco Casolino, Claudio Fornaro, Hanna Rothkaehl, I. Fernández-Gómez, M. Karus, Pierre Barrillon, M. Bogomilov, C. De Donato, F. Sarazin, Marc Weber, Alberto Cellino, Soon-Wook Kim, Gali Garipov, Domenico Finco, Dmitry V. Naumov, Andrii Neronov, G. Roudil, J. S. Kim, P. L. Biermann, F. Cafagna, G. Modestino, E. Joven, M. I. Panasyuk, L. R. Wiencke, V. S. Morozenko, A. Jung, M. Putis, F. Kajino, A. Sobey, Hiroyuki Sagawa, B. Harlov, Carlo Vigorito, C. Lachaud, S. Dagoret-Campagne, Yoshitaka Itow, I. Rusinov, T. Mernik, M. Flamini, G. Giraudo, K. Higashide, A. Insolia, M. Kleifges, P. Picozza, J. Lee, K. Kudela, T. Paul, K. Yoshida, M. Dupieux, Thomas J. Weiler, D. Maravilla, H. W. Park, S. Perez Cano, Y. Takizawa, C. Blaksley, T. Shibata, J. F. Valdés-Galicia, L. G. Tkachev, Y. Karadzhov, K. Shinozaki, Marcos Reyes, S. Csorna, G. Vankova, R. Nava, N. Sakaki, Maxim Gonchar, Hirohiko M. Shimizu, Z. Włodarczyk, G. Medina-Tanco, A. Dell’Oro, Toshitaka Kajino, L. Valore, S. Biktemerova, M. Rybczyński, Rossella Caruso, K. Kawai, S. Sánchez, G. Castellinic, Alfonso Monaco, Toshiyuki Nonaka, C. Moretto, P. Galeotti, Akinori Saito, Markus Roth, R. Bechini, Simona Toscano, C. Tenzer, T. Sugiyama, P. Gorodetzky, G. Cordero, J. Geary, Tadeusz Wibig, Ralph Engel, N. De Simone, Fausto Guarino, P. von Ballmoos, M. Ricci, Jianyi Yang, Taka Tomida, Shigeto Watanabe, Javier Licandro, P. Prat, A. Haungs, Yoshimasa Kurihara, Hajime Yano, S. Selmane, Lech Wiktor Piotrowski, H. Schieler, S. Piraino, Tokonatsu Yamamoto, P. Baragatti, Mitsuteru Sato, I. V. Yashin, S. Yoshida, J. Szabelski, Humberto Ibarguen Salazar, Frederic Trillaud, G. Catalano, R. Matev, T. Pierog, J. Watanabe, L. Marcelli, M. Takeda, C. De Santis, H. Tokuno, M. Suzuki, D. Campana, A. Anzalone, T. Napolitano, D. Monnier-Ragaigne, A. Segreto, Inkyu Park, T. Patzak, Y. Miyazaki, M. D. Rodríguez Frías, Mark Christl, O. Martinez, O. Tibolla, Tomás Belenguer, Patrick J. Reardon, A. Bruno, Z. Plebaniak, J. Blümer, R. Tsenov, K. Belov, C. Catalano, N. Blanc, Toshiki Tajima, G. Siemieniec-Oziȩbło, S. Falk, A. Pollini, G. Masciantonio, Hitoshi Ohmori, Pavel Klimov, Karl Mannheim, Michael S. Briggs, A. J. de Castro, Michiyuki Chikawa, Yoshiya Kawasaki, H. J. Crawford, D. Semikoz, L. Villaseñor, D. Allard, G. Sáez-Cano, M. Serra, Luis A. Anchordoqui, S. A. Sharakin, M. E. Bertaina, T. Batsch, S. Blin-Bondil, Ken'ichi Nomoto, I. Kaneko, Piero Vallania, D. Supanitsky, M. D. Sabau, J. Bayer, C. de la Taille, K. Katahira, A. Ebersoldt, Shoichi Ogio, Yoshiki Tsunesada, Hajime Takami, Masaki Fukushima, T. Nakamura, B. A. Khrenov, H. Miyamoto, J. Fujimoto, P. Bobik, and Valentina Scotti
Subjects: Physics, Particle physics, Space and Planetary Science, Astronomy and Astrophysics, Astrophysics
Abstract: The online version of the original article can be found at http://dx.doi.org/10.1007/s10686-013-9371-0 .
Published: 2015

149. Small Carry-on Impactor of Hayabusa2 Mission

Author: Y. Takagi, Hajime Yano, Hirotaka Sawada, Chisato Okamoto, Makoto Yoshikawa, Yasuhiro Akahoshi, and Takanao Saiki
Subjects: business.product_category, Explosive material, Spacecraft, business.industry, Computer science, Aerospace Engineering, Acceleration, Explosive device, Impact crater, Aeronautics, Rocket, Asteroid, Aerospace engineering, business, Guidance system
Abstract: Accepted: 2012-11-21, 資料番号: SA1004111000
Published: 2013

150. High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats

Author: Yoshito Ishizaki, Yusuke I. Shimizu, Hisaaki Takahashi, Yoshiaki Yano, Eiichi Ishii, Masanori Ito, Junya Tanaka, Hajime Yano, and Mitsumasa Fukuda
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Neurology, Fever, Hippocampus, chemical and pharmacologic phenomena, Electroencephalography, Corpus callosum, Biochemistry, Epileptogenesis, Seizures, Febrile, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, Epilepsy, 0302 clinical medicine, Seizures, Febrile seizure, Internal medicine, medicine, Avoidance Learning, Animals, HMGB1 Protein, medicine.diagnostic_test, Dose-Response Relationship, Drug, business.industry, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, Endocrinology, Anesthesia, Neurology (clinical), Epileptic seizure, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Levels of high mobility group box 1 (HMGB1), an important inflammatory mediator, are high in the serum of febrile seizure (FS) patients. However, its roles in FS and secondary epilepsy after prolonged FS are poorly understood. We demonstrate HMGB1’s role in the pathogenesis of hyperthermia-induced seizures (HS) and secondary epilepsy after prolonged hyperthermia-induced seizures (pHS). In the first experiment, 14–15-day-old male rats were divided into four groups: high-dose HMGB1 (100 μg), moderate-dose (10 μg), low-dose (1 μg), and control. Each rat was administered HMGB1 intranasally 1 h before inducing HS. Temperature was measured at seizure onset with electroencephalography (EEG). In the second experiment, 10–11-day-old rats were divided into four groups: pHS + HMGB1 (10 μg), pHS, HMGB1, and control. HMGB1 was administered 24 h after pHS. Video-EEGs were recorded for 24 h at 90 and 120 days old; histological analysis was performed at 150 days old. In the first experiment, the temperature at seizure onset was significantly lower in the high- and moderate-dose HMGB1 groups than in the control group. In the second experiment, the incidence of spontaneous epileptic seizure was significantly higher in the pHS + HMGB1 group than in the other groups. Comparison between pHS + HMGB1 groups with and without epilepsy revealed that epileptic rats had significantly enhanced astrocytosis in the hippocampus and corpus callosum. In developing rats, HMGB1 enhanced HS and secondary epilepsy after pHS. Our findings suggest that HMGB1 contributes to FS pathogenesis and plays an important role in the acquired epileptogenesis of secondary epilepsy associated with prolonged FS.
Published: 2016

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