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102. Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)

Author

Gianotti, L, Besselink, M, Sandini, M, Hackert, T, Conlon, K, Gerritsen, A, Griffin, O, Fingerhut, A, Probst, P, Hilal, M, Marchegiani, G, Nappo, G, Zerbi, A, Amodio, A, Perinel, J, Adham, M, Raimondo, M, Asbun, H, Sato, A, Takaori, K, Shrikhande, S, Del Chiaro, M, Bockhorn, M, Izbicki, J, Dervenis, C, Charnley, R, Martignoni, M, Friess, H, de Pretis, N, Radenkovic, D, Montorsi, M, Sarr, M, Vollmer, C, Frulloni, L, Buchler, M, Bassi, C, Gianotti L., Besselink M. G., Sandini M., Hackert T., Conlon K., Gerritsen A., Griffin O., Fingerhut A., Probst P., Hilal M. A., Marchegiani G., Nappo G., Zerbi A., Amodio A., Perinel J., Adham M., Raimondo M., Asbun H. J., Sato A., Takaori K., Shrikhande S. V., Del Chiaro M., Bockhorn M., Izbicki J. R., Dervenis C., Charnley R. M., Martignoni M. E., Friess H., de Pretis N., Radenkovic D., Montorsi M., Sarr M. G., Vollmer C. M., Frulloni L., Buchler M. W., Bassi C., Gianotti, L, Besselink, M, Sandini, M, Hackert, T, Conlon, K, Gerritsen, A, Griffin, O, Fingerhut, A, Probst, P, Hilal, M, Marchegiani, G, Nappo, G, Zerbi, A, Amodio, A, Perinel, J, Adham, M, Raimondo, M, Asbun, H, Sato, A, Takaori, K, Shrikhande, S, Del Chiaro, M, Bockhorn, M, Izbicki, J, Dervenis, C, Charnley, R, Martignoni, M, Friess, H, de Pretis, N, Radenkovic, D, Montorsi, M, Sarr, M, Vollmer, C, Frulloni, L, Buchler, M, Bassi, C, Gianotti L., Besselink M. G., Sandini M., Hackert T., Conlon K., Gerritsen A., Griffin O., Fingerhut A., Probst P., Hilal M. A., Marchegiani G., Nappo G., Zerbi A., Amodio A., Perinel J., Adham M., Raimondo M., Asbun H. J., Sato A., Takaori K., Shrikhande S. V., Del Chiaro M., Bockhorn M., Izbicki J. R., Dervenis C., Charnley R. M., Martignoni M. E., Friess H., de Pretis N., Radenkovic D., Montorsi M., Sarr M. G., Vollmer C. M., Frulloni L., Buchler M. W., and Bassi C.

Abstract

Background: The optimal nutritional therapy in the field of pancreatic surgery is still debated. Methods: An international panel of recognized pancreatic surgeons and pancreatologists decided that the topic of nutritional support was of importance in pancreatic surgery. Thus, they reviewed the best contemporary literature and worked to develop a position paper to provide evidence supporting the integration of appropriate nutritional support into the overall management of patients undergoing pancreatic resection. Strength of recommendation and quality of evidence were based on the approach of the grading of recommendations assessment, development and evaluation Working Group. Results: The measurement of nutritional status should be part of routine preoperative assessment because malnutrition is a recognized risk factor for surgery-related complications. In addition to patient's weight loss and body mass index, measurement of sarcopenia and sarcopenic obesity should be considered in the preoperative evaluation because they are strong predictors of poor short-term and long-term outcomes. The available data do not show any definitive nutritional advantages for one specific type of gastrointestinal reconstruction technique after pancreatoduodenectomy over the others. Postoperative early resumption of oral intake is safe and should be encouraged within enhanced recovery protocols, but in the case of severe postoperative complications or poor tolerance of oral food after the operation, supplementary artificial nutrition should be started at once. At present, there is not enough evidence to show the benefit of avoiding oral intake in clinically stable patients who are complicated by a clinically irrelevant postoperative pancreatic fistula (a so-called biochemical leak), while special caution should be given to feeding patients with clinically relevant postoperative pancreatic fistula orally. When an artificial nutritional support is needed, enteral nutrition is preferred wh

Published
2018

103. Associations between pancreatic expression quantitative trait loci (eQTLs) and pancreatic ductal adenocarcinoma risk

Author

Gentiluomo, M., Pistoni, L., Peduzzi, G., Lu, Y., Macauda, A., Hlavac, V., Vanella, G., Darvasi, E., Milanetto, A. C., Oliverius, M., Vashist, Y., Di Leo, M., Mohelnikova-Duchonova, B., Talar-Wojnarowska, R., Gheorghe, C., Petrone, M., Strobel, O., Arcidiacono, P., Vodickova, L., Szentesi, A., Capurso, G., Gajdan, L., Malleo, G., Theodoropoulos, G., Basso, D., Soucek, P., Brenner, H., Lawlor, R., Morelli, L., Ivanauskas, A., Kauffmann, E., Gazouli, M. Archibugi L., Nentwich, M., Lovecek, M., Cavestro, G., Vodicka, P., Landi, S., Tavano, F., Sperti, C., Hackert, T., Kupcinsckas, J., Pezzilli, R., Andriulli, A., Pollina, L., Kreivenaite, E., Gioffreda, D., Jamroziak, K., Hegyi, P., Izbicki, J., Testoni, S., Zuppardo, R., Bozzato, D., Neoptolemos, J., Canzian, F., and Campa, D

Published
2020

104. Polymorphic variants with non-coding RNA and risk of pancreatic ductal adenocarcinoma

Author

Gentiluomo, M., Corradi, C., Lu, Y., Giaccherini, M., Hegyi, P., Pezzilli, R., Tavano, F., Szentesi, A., Gajdan, L., Nentwich, M., Strobel, O., Gazouli, M., Cavestro, G., Darvasi, E., Arcidiacono, P., Landi, S., Luchini, C., Gioffreda, D., Kupcinsckas, J., Hackert, T., Neoptolemos, J., Morelli, L., Kreivenaite, E., Zuppardo, R., Carrara, S., Di Franco, G., Brenner, H., Hlavac, V., Sperti, C., Milanetto, A. C., Moz, S., Mohelnikova-Duchonova, B., Petrone, M., Lawlor, R., Vanella, G., Vashist, Y., Soucek, P., Vodicka, P., Cervena, K., Capurso, G., Malenka-Panas, E., Pasquali, C., Archibugi, L., Gheorghe, C., Andriulli, A., Ivanauskas, A., Theodoropoulos, G., Jamroziak, K., Izbicki, J., Testoni, S., Oliverius, M., Napoli, N., Canzian, F., and Campa, D.

Published
2020

105. Genome-wide association study identifies an early onset pancreatic cancer risk locus

Author

Campa, D. Gentiluomo, M. Obazee, O. Ballerini, A. Vodickova, L. Hegyi, P. Soucek, P. Brenner, H. Milanetto, A.C. Landi, S. Gao, X. Bozzato, D. Capurso, G. Tavano, F. Vashist, Y. Hackert, T. Bambi, F. Bursi, S. Oliverius, M. Gioffreda, D. Schöttker, B. Ivanauskas, A. Mohelnikova-Duchonova, B. Darvasi, E. Pezzilli, R. Małecka-Panas, E. Strobel, O. Gazouli, M. Katzke, V. Szentesi, A. Cavestro, G.M. Farkas, G., Jr. Izbicki, J.R. Moz, S. Archibugi, L. Hlavac, V. Vincze, Á. Talar-Wojnarowska, R. Rusev, B. Kupcinskas, J. Greenhalf, B. Dijk, F. Giese, N. Boggi, U. Andriulli, A. Busch, O.R. Vanella, G. Vodicka, P. Nentwich, M. Lawlor, R.T. Theodoropoulos, G.E. Jamroziak, K. Zuppardo, R.A. Moletta, L. Ginocchi, L. Kaaks, R. Neoptolemos, J.P. Lucchesi, M. Canzian, F.

Abstract

Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome-wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset ≤60 years, of whom 198 with age of onset ≤50, and 3227 controls from PanScan I-II, we observed four SNPs (rs7155613, rs2328991, rs4891017 and rs12610094) showing an association with EOPC risk (P < 1 × 10−4). We replicated these SNPs in the PANcreatic Disease ReseArch (PANDoRA) consortium and used additional in silico data from PanScan III and PanC4. Among these four variants rs2328991 was significant in an independent set of 855 cases with age of onset ≤60 years, of whom 265 with age of onset ≤50, and 4142 controls from the PANDoRA consortium while in the in silico data, we observed no statistically significant association. However, the resulting meta-analysis supported the association (P = 1.15 × 10−4). In conclusion, we propose a novel variant rs2328991 to be involved in EOPC risk. Even though it was not possible to find a mechanistic link between the variant and the function, the association is supported by a solid statistical significance obtained in the largest study on EOPC genetics present so far in the literature. © 2020 UICC

Published
2020

107. Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, F, Hung, RJ, Walsh, N, Zhang, H, Platz, EA, Wheeler, W, Song, L, Arslan, AA, Freeman, LEB, Bracci, P, Canzian, F, Du, M, Gallinger, S, Giles, GG, Goodman, PJ, Kooperberg, C, Le Marchand, L, Neale, RE, Rosendahl, J, Scelo, G, Shu, X-O, Visvanathan, K, White, E, Zheng, W, Albanes, D, Amiano, P, Andreotti, G, Babic, A, Bamlet, WR, Berndt, SI, Brennan, P, Bueno-de-Mesquita, B, Buring, JE, Campbell, PT, Chanock, SJ, Fuchs, CS, Gaziano, JM, Goggins, MG, Hackert, T, Hartge, P, Hassan, MM, Holly, EA, Hoover, RN, Katzke, V, Kirsten, H, Kurtz, RC, Lee, I-M, Malats, N, Milne, RL, Murphy, N, Ng, K, Oberg, AL, Porta, M, Rabe, KG, Real, FX, Rothman, N, Sesso, HD, Silverman, DT, Thompson, IM, Wactawski-Wende, J, Wang, X, Wentzensen, N, Wilkens, LR, Yu, H, Zeleniuch-Jacquotte, A, Shi, J, Duell, EJ, Amundadottir, LT, Li, D, Petersen, GM, Wolpin, BM, Risch, HA, Yu, K, Klein, AP, Stolzenberg-Solomon, R, Yuan, F, Hung, RJ, Walsh, N, Zhang, H, Platz, EA, Wheeler, W, Song, L, Arslan, AA, Freeman, LEB, Bracci, P, Canzian, F, Du, M, Gallinger, S, Giles, GG, Goodman, PJ, Kooperberg, C, Le Marchand, L, Neale, RE, Rosendahl, J, Scelo, G, Shu, X-O, Visvanathan, K, White, E, Zheng, W, Albanes, D, Amiano, P, Andreotti, G, Babic, A, Bamlet, WR, Berndt, SI, Brennan, P, Bueno-de-Mesquita, B, Buring, JE, Campbell, PT, Chanock, SJ, Fuchs, CS, Gaziano, JM, Goggins, MG, Hackert, T, Hartge, P, Hassan, MM, Holly, EA, Hoover, RN, Katzke, V, Kirsten, H, Kurtz, RC, Lee, I-M, Malats, N, Milne, RL, Murphy, N, Ng, K, Oberg, AL, Porta, M, Rabe, KG, Real, FX, Rothman, N, Sesso, HD, Silverman, DT, Thompson, IM, Wactawski-Wende, J, Wang, X, Wentzensen, N, Wilkens, LR, Yu, H, Zeleniuch-Jacquotte, A, Shi, J, Duell, EJ, Amundadottir, LT, Li, D, Petersen, GM, Wolpin, BM, Risch, HA, Yu, K, Klein, AP, and Stolzenberg-Solomon, R

Abstract

Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at P values < 0.05 (0.0040, 0.0057, 0.011, and 3.4 × 10-6, respectively). After excluding the 20 PDAC susceptibility regions (±500 kb) previously identified by GWAS, the genomic regions for ulcerative colitis, Crohn disease, and inflammatory bowel disease remained associated with PDAC (P = 0.0029, 0.0057, and 0.0098, respectively). Genomic regions for celiac disease (P = 0.22) and primary sclerosing cholangitis (P = 0.078) were not associated with PDAC. Our results support the hypothesis that genomic regions surrounding variants associated with inflammatory intestinal diseases, particularly, ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis are associated with PDAC. SIGNIFICANCE: The joint effects of common variants in genomic regions containing susceptibility loci for infla

Published
2020

110. Global Outcomes and Learning Curve for Clinical Outcomes and Proficiency of Robotic Pancreatoduodenectomy

Author

Jones, L.R., primary, Zwart, M.J., additional, de Graaf, N., additional, Luyer, M.D., additional, Saint-Marc, O., additional, Moraldi, L., additional, Groot Koerkamp, B., additional, de Wilde, R., additional, Lips, D.J., additional, Molenaar, I.Q., additional, Hackert, T., additional, Bonsing, B.A., additional, Moo Kang, C., additional, Shen, B., additional, Shyr, Y.-M., additional, Shan, Y.-S., additional, Peng, C.-M., additional, Machado, M., additional, Kim, H., additional, Boggi, U., additional, Jang, J.-Y., additional, Besselink, M.G., additional, and Abu Hilal, M., additional

Published
2021
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112. A novel microfluidic-based assay to determine high-risk pancreatic cysts for surgery utilizing pancreatic cyst fluid: an international multicenter study

Author

Kone, L., primary, Pollini, T., additional, Brugge, W., additional, Castillo, C Fernandez-del, additional, Winter, J., additional, Yeo, C.J., additional, Hackert, T., additional, Buchler, M.W., additional, Roggin, K., additional, Schmidt, C.M., additional, Yip-Schnieder, M., additional, Salvia, R., additional, Bassi, C., additional, Chlipala, G., additional, and Maker, A.V., additional

Published
2021
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118. Oncological Outcomes of Minimally-invasive and Open Pancreatoduodenectomy for PDAC: An International Retrospective Propensity-score Matched Study

Author

Vissers, F., primary, van Roessel, S., additional, Rosso, E., additional, Kauffmann, E., additional, Klompmaker, S., additional, Alseidi, A., additional, Coratti, A., additional, Dokmak, S., additional, Espopsito, A., additional, Fuks, D., additional, Groot Koerkamp, B., additional, Hackert, T., additional, Halimi, A., additional, Keck, T., additional, Kerem, M., additional, Khatkov, I., additional, Molenaar, Q., additional, Saint-Marc, O., additional, van Santvoort, H., additional, Wittel, U., additional, Wolfgang, C., additional, Abu Hilal, M., additional, Besselink, M., additional, and Boggi, U., additional

Published
2021
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120. First Year of the European Registry for Minimally Invasive Pancreatic Surgery (E-MIPS)

Author

van der Heijde, N., primary, Vissers, F., additional, Manzoni, A., additional, Zimmitti, G., additional, Balsells, J., additional, Berrevoet, F., additional, Bjornsson, B., additional, van den Boezem, P., additional, Boggi, U., additional, Bratlie, S.O., additional, Burdio, F., additional, Coratti, A., additional, D'Hondt, M., additional, Del Pozo, D., additional, Dokmak, S., additional, Fara, R., additional, Fatih Can, M., additional, Festen, S., additional, Forgione, A., additional, Fristrup, C., additional, Gaujoux, S., additional, Groot Koerkamp, B., additional, Hackert, T., additional, Khatkov, I., additional, Keck, T., additional, Kokkola, A., additional, Lips, D., additional, Luyer, M., additional, Pittau, G., additional, Maglione, M., additional, Molenaar, I.Q., additional, Pessaux, P., additional, Roeyen, G., additional, Saint-Marc, O., additional, Sanchez Cabus, S., additional, van Santvoort, H., additional, van der Schelling, G., additional, Serradilla-Martin, M., additional, Souche, F.-R., additional, Suarez Munoz, M.A., additional, Vito Marino, M., additional, Besselink, M., additional, and Abu Hilal, M., additional

Published
2021
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133. Adjuvant chemotherapy in patients with resected pancreatic cancer following neoadjuvant FOLFIRINOX chemotherapy: an international multicenter study

Author

Van Roessel, S., primary, Van Veldhuisen, E., additional, Jansen, K., additional, Abu Hilal, M., additional, Alseidi, A., additional, Bassi, C., additional, Malleo, G., additional, Del Chiaro, M., additional, Hackert, T., additional, Falconi, M., additional, Mortensen, M., additional, Lesurtel, M., additional, Keck, T., additional, Pietrasz, D., additional, Strobel, O., additional, Tarvainen, T., additional, Van Laarhoven, H., additional, Wilmink, H., additional, Groot Koerkamp, B., additional, and Besselink, M., additional

Published
2020
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134. ESPAC-5F: Four arm, international randomised phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer

Author

Ghaneh, P., primary, Palmer, D., additional, Cicconi, S., additional, Halloran, C., additional, Psarelli, E., additional, Rawcliffe, C., additional, Sripadam, R., additional, Mukherjee, S., additional, Wadsley, J., additional, Al-Mukhtar, A., additional, Jiao, L., additional, Wasan, H., additional, Carter, R., additional, Graham, J., additional, Ammad, F., additional, Evans, J., additional, Tjaden, C., additional, Hackert, T., additional, Buchler, M., additional, and Neoptolemos, J., additional

Published
2020
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135. ESPAC-4: A randomized controlled phase III trial of adjuvant gemcitabine (GEM) and capecitabine (CAP) versus gemcitabine in resected pancreatic ductal adenocarcinoma: five year follow up.

Author

Neoptolemos, J., primary, Palmer, D., additional, Gahneh, P., additional, Valle, J., additional, Cunningham, D., additional, Wadsley, J., additional, Meyer, T., additional, Anthoney, A., additional, Glimelius, B., additional, Falk, S., additional, Segersvard, R., additional, Middleton, G., additional, Ross, P., additional, Wasan, H., additional, Mcdonald, A., additional, Crosby, T., additional, Psarelli, E., additional, Hammel, P., additional, Hackert, T., additional, Halloran, C., additional, and Buchler, M., additional

Published
2020
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138. A Pretreatment Prognostic Score to Stratify Survival in Pancreatic Cancer: The Heidelberg Prognostic Pancreatic Cancer (HELPP)-Score.

Author

Hank, T., primary, Hinz, U., additional, Thomas, R., additional, Malleo, G., additional, König, A., additional, Maggino, L., additional, Niesen, W., additional, Marchegiani, G., additional, Kaiser, J., additional, Paiella, S., additional, Binco, A., additional, Salvia, R., additional, Hackert, T., additional, Bassi, C., additional, Büchler, M., additional, and Strobel, O., additional

Published
2020
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144. Laparoscopic extended versus open extended distal pancreatectomy for ductal adenocarcinoma: A pan-European propensity-score matched study

Author

Balduzzi, A., primary, Van Hilst, J., additional, Korrel, M., additional, Lof, S., additional, Al-Sarireh, B., additional, Alseidi, A., additional, Berrevoet, F., additional, Bjo¨rnsson, B., additional, Van den Boezem, P., additional, Boggi, U., additional, Busch, O., additional, Butturini, G., additional, Casadei, R., additional, Van dam, R., additional, Dokmak, S., additional, Edwin, B., additional, Fabre, J.M., additional, Falconi, M., additional, Forgione, A., additional, Gayet, B., additional, Gomez, D., additional, Koerkamp, B Groot, additional, Hackert, T., additional, Keck, T., additional, Khatkov, I., additional, Marudanayagam, R., additional, Menon, K., additional, Pietrabissa, A., additional, Poves, I., additional, Salvia, R., additional, and Sa´nchez-Cabu´s, S., additional

Published
2020
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146. Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma

Author

Obazee, O., Archibugi, L., Andriulli, A., Soucek, P., Malecka-Panas, E., Ivanauskas, A., Johnson, T., Gazouli, M., Pausch, T., Lawlor, R. T., Cavestro, G. M., Milanetto, A. C., Di Leo, M., Pasquali, C., Hegyi, P., Szentesi, A., Radu, C. E., Gheorghe, C., Theodoropoulos, G. E., Bergmann, F., Brenner, H., Vodickova, L., Katzke, V., Campa, D., Strobel, O., Kaiser, J., Pezzilli, R., Federici, F., Mohelnikova-Duchonova, B., Boggi, U., Lemstrova, R., Johansen, J. S., Bojesen, S. E., Chen, I., Jensen, B. V., Capurso, G., Pazienza, V., Dervenis, C., Sperti, C., Mambrini, A., Hackert, T., Kaaks, R., Basso, D., Talar-Wojnarowska, R., Maiello, E., Izbicki, J. R., Cuk, K., Saum, K. U., Cantore, M., Kupcinskas, J., Palmieri, O., Delle Fave, G., Landi, S., Salvia, R., Fogar, P., Vashist, Y. K., Scarpa, A., Vodicka, P., Tjaden, C., Iskierka-Jazdzewska, E., Canzian, F., Obazee, O., Archibugi, L., Andriulli, A., Soucek, P., Malecka-Panas, E., Ivanauskas, A., Johnson, T., Gazouli, M., Pausch, T., Lawlor, R. T., Cavestro, G. M., Milanetto, A. C., Di Leo, M., Pasquali, C., Hegyi, P., Szentesi, A., Radu, C. E., Gheorghe, C., Theodoropoulos, G. E., Bergmann, F., Brenner, H., Vodickova, L., Katzke, V., Campa, D., Strobel, O., Kaiser, J., Pezzilli, R., Federici, F., Mohelnikova-Duchonova, B., Boggi, U., Lemstrova, R., Johansen, J. S., Bojesen, S. E., Chen, I., Jensen, B. V., Capurso, G., Pazienza, V., Dervenis, C., Sperti, C., Mambrini, A., Hackert, T., Kaaks, R., Basso, D., Talar-Wojnarowska, R., Maiello, E., Izbicki, J. R., Cuk, K., Saum, K. U., Cantore, M., Kupcinskas, J., Palmieri, O., Delle Fave, G., Landi, S., Salvia, R., Fogar, P., Vashist, Y. K., Scarpa, A., Vodicka, P., Tjaden, C., Iskierka-Jazdzewska, E., and Canzian, F.

Subjects
Male, Cancer Research, pancreatic cancer, Genes, BRCA2, I157T, Polymorphism, Single Nucleotide, Humans, Genetic Predisposition to Disease, Germ-Line Mutation, Aged, BRCA2 Protein, K3326X, PANDoRA consortium, rs11571833, rs17879961, Oncology, Pancreatic cancer, Middle Aged, Pancreatic Neoplasms, Checkpoint Kinase 2, Case-Control Studies, Female, Carcinoma, Pancreatic Ductal
Abstract

Rare truncating BRCA2 K3326X (rs11571833) and pathogenic CHEK2 I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. The effect of both mutations in important DNA repair genes on sporadic PDAC risk may shed light on the genetic architecture of this disease. Both mutations were genotyped in germline DNA from 2,935 sporadic PDAC cases and 5,626 control subjects within the PANcreatic Disease ReseArch (PANDoRA) consortium. Risk estimates were evaluated using multivariate unconditional logistic regression with adjustment for possible confounders such as sex, age and country of origin. Statistical analyses were two-sided with p values

Published
2018

147. Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) : An International Multicenter Analysis

Author

Klompmaker, S., Peters, N. A., van Hilst, J., Bassi, C., Boggi, U., Busch, O. R., Niesen, W., Van Gulik, T. M., Javed, A. A., Kleeff, J., Kawai, M., Lesurtel, M., Lombardo, C., Moser, A. J., Okada, K. -I., Popescu, I., Prasad, R., Salvia, R., Sauvanet, A., Sturesson, C., Weiss, M. J., Zeh, H. J., Zureikat, A. H., Yamaue, H., Wolfgang, C. L., Hogg, M. E., Besselink, M. G., Gerritsen, S. L., Adham, M., Albiol Quer, M. T., Berrevoet, F., Cesaretti, M., Dalla Valle, R., Darnis, B., Diener, M. K., Del Chiaro, M., Hackert, T. H., Grutzmann, R., Dumitrascu, T., Friess, H., Hirono, S., Ivanecz, A., Karayiannakis, A., Fusai, G. K., Labori, K. J., Lopez-Ben, S., Mabrut, J. -Y., Miyazawa, M., Pardo, F., Perinel, J., Roeyen, G., Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, Surgery, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and E-AHPBA DP-CAR Study Grp

Subjects
Male, medicine.medical_specialty, Pancreatic Neoplasms/pathology, SURGERY, medicine.medical_treatment, Pancreatectomy/mortality, Pancreatectomy, Celiac artery, Celiac Artery, Pancreatic cancer, medicine.artery, Medicine and Health Sciences, Aged, Female, Follow-Up Studies, Humans, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, Survival Rate, Treatment Outcome, Patient Selection, Journal Article, Medicine, Survival rate, ARTERY, Framingham Risk Score, business.industry, Mortality rate, Celiac Artery/surgery, ADENOCARCINOMA, Retrospective cohort study, medicine.disease, Surgery, ddc, MODEL, Multicenter Study, DEFINITION, Oncology, Hepatobiliary Tumors, VOLUME, Adenocarcinoma, Human medicine, business
Abstract

Background Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day mortality rate of 16%, highlighting the importance of patient selection. The authors constructed a risk score to predict 90-day mortality and assessed oncologic outcomes. Methods This multicenter retrospective cohort study investigated patients undergoing DP-CAR at 20 European centers from 12 countries (model design 2000–2016) and three very-high-volume international centers in the United States and Japan (model validation 2004–2017). The area under receiver operator curve (AUC) and calibration plots were used for validation of the 90-day mortality risk model. Secondary outcomes included resection margin status, adjuvant therapy, and survival. Results For 191 DP-CAR patients, the 90-day mortality rate was 5.5% (95 confidence interval [CI], 2.2–11%) at 5 high-volume (≥ 1 DP-CAR/year) and 18% (95 CI, 9–30%) at 18 low-volume DP-CAR centers (P = 0.015). A risk score with age, sex, body mass index (BMI), American Society of Anesthesiologists (ASA) score, multivisceral resection, open versus minimally invasive surgery, and low- versus high-volume center performed well in both the design and validation cohorts (AUC, 0.79 vs 0.74; P = 0.642). For 174 patients with pancreatic ductal adenocarcinoma, the R0 resection rate was 60%, neoadjuvant and adjuvant therapies were applied for respectively 69% and 67% of the patients, and the median overall survival period was 19 months (95 CI, 15–25 months). Conclusions When performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor. Electronic supplementary material The online version of this article (10.1245/s10434-018-07101-0) contains supplementary material, which is available to authorized users.

Published
2019

148. Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma

Author

Obazee, O. Archibugi, L. Andriulli, A. Soucek, P. Małecka-Panas, E. Ivanauskas, A. Johnson, T. Gazouli, M. Pausch, T. Lawlor, R.T. Cavestro, G.M. Milanetto, A.C. Di Leo, M. Pasquali, C. Hegyi, P. Szentesi, A. Radu, C.E. Gheorghe, C. Theodoropoulos, G.E. Bergmann, F. Brenner, H. Vodickova, L. Katzke, V. Campa, D. Strobel, O. Kaiser, J. Pezzilli, R. Federici, F. Mohelnikova-Duchonova, B. Boggi, U. Lemstrova, R. Johansen, J.S. Bojesen, S.E. Chen, I. Jensen, B.V. Capurso, G. Pazienza, V. Dervenis, C. Sperti, C. Mambrini, A. Hackert, T. Kaaks, R. Basso, D. Talar-Wojnarowska, R. Maiello, E. Izbicki, J.R. Cuk, K. Saum, K.U. Cantore, M. Kupcinskas, J. Palmieri, O. Delle Fave, G. Landi, S. Salvia, R. Fogar, P. Vashist, Y.K. Scarpa, A. Vodicka, P. Tjaden, C. Iskierka-Jazdzewska, E. Canzian, F.

Abstract

Rare truncating BRCA2 K3326X (rs11571833) and pathogenic CHEK2 I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. The effect of both mutations in important DNA repair genes on sporadic PDAC risk may shed light on the genetic architecture of this disease. Both mutations were genotyped in germline DNA from 2,935 sporadic PDAC cases and 5,626 control subjects within the PANcreatic Disease ReseArch (PANDoRA) consortium. Risk estimates were evaluated using multivariate unconditional logistic regression with adjustment for possible confounders such as sex, age and country of origin. Statistical analyses were two-sided with p values

Published
2019

149. Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA)

Author

van Hilst, J, de Rooij, T, Klompmaker, S, Rawashdeh, M, Aleotti, F, Al-Sarireh, B, Alseidi, A, Ateeb, Z, Balzano, G, Berrevoet, F, Bjornsson, B, Boggi, U, Busch, Or, Butturini, G, Casadei, R, Del Chiaro, M, Chikhladze, S, Cipriani, F, van Dam, R, Damoli, I, van Dieren, S, Dokmak, S, Edwin, B, van Eijck, C, Fabre, Jm, Falconi, M, Farges, O, Fernandez-Cruz, L, Forgione, A, Frigerio, I, Fuks, D, Gavazzi, F, Gayet, B, Giardino, A, Koerkamp, Bg, Hackert, T, Hassenpflug, M, Kabir, I, Keck, T, Khatkov, I, Kusar, M, Lombardo, C, Marchegiani, G, Marshall, R, Menon, Kv, Montorsi, M, Orville, M, de Pastena, M, Pietrabissa, A, Poves, I, Primrose, J, Pugliese, R, Ricci, C, Roberts, K, Rosok, B, Sahakyan, Ma, Sanchez-Cabus, S, Sandstrom, P, Scovel, L, Solaini, L, Soonawalla, Z, Souche, Fr, Sutcliffe, Rp, Tiberio, Ga, Tomazic, A, Troisi, R, Wellner, U, White, S, Wittel, Ua, Zerbi, A, Bassi, C, Besselink, Mg, and Abu Hilal, M

Subjects
Male, robot-assisted, laparoscopic, Pancreatectomy, Postoperative Complications, Robotic Surgical Procedures, Humans, Minimally Invasive Surgical Procedures, distal pancreatectomy, Propensity Score, Aged, Neoplasm Staging, Retrospective Studies, Incidence, Carcinoma, Length of Stay, left pancreatectomy, minimally invasive, Pancreatic Ductal, Europe, Female, Laparoscopy, Pancreatic Neoplasms, Survival Rate, Treatment Outcome, Carcinoma, Pancreatic Ductal
Published
2019

150. A multifactorial score for pancreatic ductal adenocarcinoma risk prediction

Author

Gentiluomo, M., Galeotti, A. A., Rizzato, C., Obazee, O., Neoptolemos, J. P., Pasquali, C., Nentwick, M., Cavestro, G. M., Pezzilli, R., Greenhalf, W., Holleczek, B., Shroeder, C., Shottker, B., Ivanauskas, A., Ginocchi, L., Key, T. J., Hegyi, P., Archibugi, L., Darvasi, E., Basso, D., Sperti, C., Bijlisma, M. F., Palmieri, G., Hlavac, V., Talar-Wojnarowska, R., Mohelnikova – Duchonova, B., Hackert, T., Vahist, Y., Strouhal, O., van Laarhoven, C., Tavano, F., Lovecek, M., Dervenis, C., Izbeki, F., Padoan, A., Malencka-Panas, E., Maiello, E., Vanella, G., Capurso, G., Izbicki, J. R., Theodoropulos, G. E., Jamroziak, K., Katzke, V., Kaaks, R., Mambrini, A., Papanikolaou, I. S., Szentesi, A., Kupcinskas, J., Bursi, S., Costello, E., Boggi, U., Milanetto, A. C., Landi, S., Gazouli, M., Vodickova, L., Soucek, P., Gioffreda, D., Gemignani, F., Brenner, H., Strobel, O., Bukler, M. W., Vodicka, P., Paiella, S, Canzian, F., and Campa, D. :.

Published
2019

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