101. Pyrazinyl and pyridinyl bis-azomethines formation: an experimental and computational study.
- Author
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Coufal, Radek and Vohlídal, Jiří
- Subjects
- *
DENSITY functional theory , *HEMIAMINALS , *NUCLEAR magnetic resonance spectroscopy , *HYDRAZINE , *HYDRAZINES - Abstract
Formation of bis-azomethines from hydrazine and heterocyclic aromatic carbaldehydes, namely pyridine-2-carbaldehyde and pyrazine-2-carbaldehyde, is studied using density functional theory. The theoretical investigation is correlated with experimental results obtained by means of NMR spectroscopy. The presence of bis-hemiaminal intermediates is evidenced by NMR spectra while surprisingly stable hemiaminal intermediate was isolated experimentally. Water, methanol and acetic acid were outlined to play a crucial role as active catalysts of elementary steps of the reaction mechanisms. The possible reaction sequences, i.e. addition-dehydration-addition-dehydration or addition-addition-dehydration-dehydration are investigated and discussed. Also, alternative mechanistic path via ionic mechanism was proposed for the formation of hemiaminals. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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