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Supplemental material, DS_10.1177_0022034519894957 for M2 Phenotype Macrophages Colocalize with Schwann Cells in Human Dental Pulp by N. Yoshiba, N. Edanami, N. Ohkura, T. Maekawa, N. Takahashi, A. Tohma, K. Izumi, T. Maeda, A. Hosoya, H. Nakamura, K. Tabeta, Y. Noiri and K. Yoshiba in Journal of Dental Research

To assess the micrometeorological consequences of rice variety choices in relation to rising CO2 associated to climate change, we quantified the interplay between rice architecture, physiology, and microclimate in current (~385 μmol mol−1) and future (~580 μmol mol−1) CO2 microenvironments. Two rice varieties contrasting in canopy structure and physiology were grown embedded in irrigated rice paddies, under elevated CO2 (using a Free-Air CO2 Enrichment facility) and ambient CO2 conditions. The high-yielding indica variety Takanari is more photosynthetically active and characterized by a more open canopy than a commonly cultivated variety Koshihikari. Our results show a strong diurnal interplay between solar angle, canopy structure, plant physiology, and the overlying atmosphere. Plant architecture was identified as a strong determinant of the relation between plant physiology and microclimate that in turn affects the surface forcing to the overlying atmosphere. Takanari was able to maintain lower canopy temperature both in current and future CO2 owing to the greater atmospheric mixing and stomatal conductance than Koshihikari. In the perspective of food security, a shift to such a higher-yielding variety would have consequences on the regional surface energy balance, which subsequently might alter regional weather.

Supplemental material, DS_10.1177_0022034520901519 for A Targeted Genetic Association Study of the Rare Type of Osteomyelitis by H. Yahara, S. Horita, S. Yanamoto, Y. Kitagawa, T. Asaka, T. Yoda, K. Morita, Y. Michi, M. Takechi, H. Shimasue, Y. Maruoka, E. Kondo, J. Kusukawa, H. Tsujiguchi, T. Sato, T. Kannon, H. Nakamura, A. Tajima, K. Hosomichi and K. Yahara in Journal of Dental Research

The class of antiperovskite compounds ${A}_{3}B\mathrm{O}$ ($A$ = Ca, Sr, Ba; $B$ = Sn, Pb) has attracted interest as a candidate three-dimensional Dirac system with topological surface states protected by crystal symmetry. A key factor underlying the rich electronic structure of ${A}_{3}B\mathrm{O}$ is the unusual valence state of $B$, i.e., a formal oxidation state of $\ensuremath{-}4$. Practically, it is not obvious whether anionic $B$ can be stabilized in thin films, due to its unusual chemistry, as well as the polar surface of ${A}_{3}B\mathrm{O}$, which may render the growth-front surface unstable. We report x-ray photoelectron spectroscopy measurements of single-crystalline films of ${\mathrm{Sr}}_{3}\mathrm{SnO}$ and ${\mathrm{Sr}}_{3}\mathrm{PbO}$ grown by molecular beam epitaxy. We observe shifts in the core-level binding energies that originate from anionic Sn and Pb, consistent with density functional theory calculations. Near the surface, we observe additional signatures of neutral or cationic Sn and Pb, which may point to an electronic or atomic reconstruction with possible impact on putative topological surface states.

Background New generation drug eluting stents (DES) have improved target vessel failure as compared with early generation DES and bare metal stent. Contemporary several new generation DES are different each other regarding strut thickness and drug and polymer type. A little is known about which stent induces a more favorable vascular healing at follow up. Purpose In this study, we compared the vascular healing at 8-month follow up by optical coherence tomography (OCT) between 4 different kinds of new generation DES. Methods We enrolled 112 consecutive patients (121 lesions) who underwent PCI using 4 kinds of new generation DES including biodegradable-polymer everolimus-eluting stents (BP-EES), biodegradable-polymer sirolimus-eluting stents (BP-SES), durable-polymer everolimus-eluting stents (DP-EES) and durable-polymer zotarolimus-eluting stents (DP-ZES) and who underwent 8-month follow up angiogram and OCT between July 2016 and April 2018. We compared the OCT parameters including percentage of covered struts, uncovered struts, well-apposed and uncovered struts, malapposed strut and mean neointimal hyperplasia (NIH) thickness between them. Results BP-EES consisted of 29 lesions, BP-SES consisted of 25 lesions, DP-EES consisted of 38 lesions and DP-ZES consisted of 29 lesions. A total of 734 frames with 5163 struts in BP-EES, 481 frames with 4214 struts in BP-SES, 783 frames with 6119 struts in DP-EES and 583 frames with 4708 struts in DP-ZES were analyzed. As shown in a table, mean NIH thickness was significantly higher in BP-EES and BP-SES. Thus, we compared the OCT parameters between durable-polymer (DP) group including DP-ZES and DP-EES and biodegradable-polymer (BP) group including BP-EES and BP-SES. The percentage of uncovered struts was significantly lower and mean NIH thickness was significantly higher in BP group than DP group. Results of OCT parameters BP-EES (n=29) BP-SES (n=25) DP-EES (n=38) DP-ZES (n=29) P value BP group (n=54) DP group (n=67) P value Covered struts (%) 89.5±13.6 92.4±8.6 85.5±17.5 85.0±17.7 0.29 90.9±11.6 85.3±17.4 0.08 Uncovered struts (%) 8.8±10.8 7.1±8.7 14.5±17.5 15.0±17.7 0.14 8.0±9.9 14.7±17.4 0.03 Well-apposed and uncovered struts (%) 7.9±9.9 5.9±7.7 11.7±13.1 12.3±14.0 0.15 7.0±8.9 11.9±13.4 0.04 Malapposed struts (%) 0.8±1.6 1.3±2.2 2.7±5.8 2.7±4.7 0.33 1.0±1.9 2.7±5.3 0.07 Mean NIH thickness (μm) 102±57 121±48 78±28 88±33 Conclusion The present OCT study demonstrated that delayed neointimal healing characterized by the presence of uncovered struts and lower mean NIH thickness was less common in BP group than DP gruop. Biodegradable-polymer may be more favorable than durable-polymer from the point of view of vascular healing.

Background Type 2 diabetic patients with coronary artery disease (CAD) is a high-risk subjects who require intensive secondary preventive management. The current guideline recommends lowering LDL-C with a statin as a first-line therapy in diabetic patients with CAD. However, its anti-atherosclerotic efficacy is diminished compared to non-diabetic subjects. These suggest the need to further identify additional therapeutic target associated with diabetic atherosclerosis. Lipoprotein (a) [Lp (a)] is a plasma lipoprotein which consists of an LDL-like particle with apolipoprotein (a). While Lp (a) has been shown to associate with ASCVD, whether this lipoprotein promotes diabetic coronary atherosclerosis under LDL-C control with a statin remains to be fully elucidated. Purpose To investigate the relationship between Lp (a) and coronary lipidic atheroma by near-infrared spectroscopy (NIRS), which quantitatively measures lipidic burden in vivo. Methods Culprit lesions in 127 type 2 diabetic patients with CAD who already received a statin were evaluated by NIRS imaging. Maximum 4-mm lipid core burden index at culprit lesion (MaxLCBI4mm) was measured. Results High-intensity statin and ezetimibe were used in 13 and 14% of study subjects, respectively. Their on-treatment LDL-C level and Lp (a) were 2.0±0.7 mmol/l and 22.1±26.7 mg/dl. Despite these lipid lowering therapy, average MaxLCBI4mm was 419.6±248.2 and MaxLCBI4mm≥400 was observed in 49% of study subjects. Multivariate linear regression analysis demonstrated LDL-C and Lp (a) as independent determinants associated with MaxLCBI4mm (Table). Of note, in subjects who achieved LDL-C Multivariate linear regression analysis t p-value Entire subjects (n=127) LDL-C 2.04 0.04 Lp (a) 2.88 Conclusions The association of Lp (a) with coronary lipid-rich atheroma even under guideline-recommended LDL-C control indictaes Lp (a) as an additional therapeutic target to further stabilize diabetic atherosclerosis.

Background Recent reports revealed that residual area stenosis (% AS) ≤30% after lesion preparation is a suitable predictor for target lesion revascularization (TLR) after drug-coated balloon (DCB) treatment for in-stent restenosis (ISR). Excimer laser coronary angioplasty (ELCA) can obtain larger lumen area and may be more useful for lesion preparation than plain old ballooning (POBA). On the other hands, it has been reported that in-stent neoatherosclerosis (NA) is major cause of restenosis. It is unclear the correlation between NA of ISR and the effect of ELCA. Thus, we compared the influence of NA which was evaluated by optical coherence tomography (OCT) on % AS for ISR treatment between ELCA and DCB (ELCA) group and POBA and DCB (non-ELCA) group and their clinical outcome. Methods We enrolled 58 consecutive ISR lesions which were treated by OCT guidance between July 2014 and July 2018 in our hospital. The lesions were divided into NA and non-NA lesions according to OCT findings. In each lesion, we compared post procedural % AS and % AS change which was calculated by the difference between pre and post procedural % AS between ELCA and non-ELCA groups. In addition, we compared 8-month major advance cardiac events (MACE) defined by composite of binary restenosis and target lesion revascularization (TLR) between ELCA and non-ELCA group in NA lesions. Results There were 19 NA (33.3%) and 39 non-NA lesions. In NA lesions, ELCA group can obtain significantly lower % AS (p=0.02) and significantly larger % AS change (p Results of %AS NA lesions (n=19) P value non-NA lesions (n=39) P value ELCA group (n=6) non-ELCA group (n=13) ELCA group (n=17) non-ELCA group (n=22) Post %AS (%) 2±21 26±25 0.02 7±29 23±19 0.07 %AS change (%) 71±15 38±19 Conclusion Although neoatherosclerosis is correlated with refractory restenosis, ELCA can improve residual area stenosis in neoatherosclerosis lesions and can achieve better clinical outcomes for in-stent neoatherosclerosis.

Background Several studies using optical coherence tomography (OCT) have shown that the prevalence of irregular protrusion was associated with the incidence of adverse cardiac events. However, the correlation between cardiac events and protrusion area is not well investigated. Method One hundred twenty-nine consecutive patients with 138 clesions with 2nd and 3rd generation drug-eluting stents (DES) which had pre-stenting and post-stenting OCT imaging between April 2016 and April 2018 were evaluated. We compared baseline characteristics, procedure findings and OCT findings including minimum stent area, protrusion type and maximum protrusion area between target lesion revascularization (TLR) group and non-TLR group. Results TLR occurred in 12 (9.3%) in 129 patients. The baseline characteristics and procedure findings were similar between TLR group and non-TLR group. Univariate analysis revealed that maximum irregular protrusion area was significantly larger (0.51 [0.00–0.63] vs 0.00 [0.00–0.27], p=0.036) in TLR group than non-TLR group. Receiver operating characteristic curve analysis revealed that the suitable cutoff value of maximum irregular protrusion area were 0.43mm2 for TLR. In multivariate analysis using the parameters with p value Odd's ratio (95% CI) P value Major irregular protrusion (≥0.43mm2) 17.3 (3.63–82.6) Conclusion Major irregular protrusion (>0.43mm2) in post-stenting OCT findings may be a powerful predictor of TLR in the patients with new generation DES.

Background Several reports have revealed that minimum lumen area (MLA) is associated with target lesion failure even with newer-generation drug-eluting stents, and calcified lesions usually induced inadequate lumen area because of stent under expansion. Contemporary debulking devices such as rotational/orbital atherectomy can modify severe calcified lesions before stenting. However, there are no optimal criteria to indicate necessity for calcium modification to obtain adequate acute gain. Therefore, we investigated useful calcium parameters correlating with MLA in the calcified lesions after stenting. Methods We enrolled 71 consecutive calcified lesions (71 patients) who underwent optical coherence tomography (OCT) guided percutaneous coronary intervention (PCI) between September 2016 and January 2019. Exclusion criteria included acute coronary syndrome, in-stent restenosis and lesions without any calcium or treated with rotational atherectomy. If there were several calcium lesions in one patient, we selected maximum calcium angle lesion. We compared mean reference area, pre lumen area and various calcium parameters including calcium arc, maximum thickness, depth, area, longitudinal length and calcium ratio that was maximum calcium thickness divided by nearest reference diameter in disease-free segments as much as possible in pre-PCI OCT evaluation with post-PCI lumen area at that site by simple and multiple regression analysis. Results Calcium ratio was an independent predictor for post-PCI lumen area in addition to mean reference area, while the others were not associated with post-PCI lumen area (table). Results of OCT parameters Univariate analysis Multivariate analysis P value P value β Mean reference area Conclusion The novel calcium measurement, calcium ratio, may be a useful predictor for post-PCI lumen area for calcified lesions.

Objectives We assessed clinical outcomes after percutaneous coronary intervention (PCI) for unprotected left main (ULM) using current generation drug eluting stents (cDES) in hemodialysis (HD) patients compared to general populations. Methods We identified 1269 consecutive patients who underwent PCI for ULM distal bifurcation lesions. Of them, 563 patients were treated with cDES (512 non HD and 51 HD patients). The primary endpoint was target lesion failure (TLF) at 3 years, defined as a composite of cardiac death, target lesion revascularization (TLR) and myocardial infarction (MI). Results HD group was more likely to have diabetes mellitus (70.0% vs. 45.8%, p=0.002), peripheral artery disease (56.0% vs. 14.9%, p Conclusions Hemodialysis was strongly associated with adverse events after PCI for ULM distal bifurcation lesions even with cDES.

Background Several reports have revealed that stent under expansion is associated with target lesion failure and calcified lesions usually induced inadequate stent expansion. Contemporary debulking devices such as rotational/orbital atherectomy can modify severe calcified lesions before stenting. However, it is uclear which calcium parameter is most useful predictor for stent expansion in the calcified lesions. Thus, we investigated useful calcium parameters correlating with stent expansion in the calcified lesions. Methods We enrolled 43 consecutive calcified lesions (43 patients) who underwent optical coherence tomography (OCT) guided percutaneous coronary intervention (PCI) between September 2016 and January 2019. We evaluated the lesions treated with post dilatation by non-compliant balloon due to stent under expansion after stenting. Exclusion criteria included acute coronary syndrome, in-stent restenosis and lesions without any calcium or treated with rotational atherectomy. If there were several calcium lesions in one patient, we selected maximum calcium angle lesion. Stent expansion defined as post-PCI lumen area divided by the values predicted by the manufactures compliance charts. We compared mean reference area, pre lesion area stenosis, calcium parameters including calcium arc, maximum thickness, area and longitudinal length in pre-PCI OCT evaluations with post-PCI stent expansion at that site. Results Maximum calcium thickness showed significant correlation with stent expansion, while the others did not show a significant correlation with stent expansion (table). The optimal thresholds of maximum calcium thickness for the prediction of acceptable stent expansion defined by 80% of the values predicted by the manufactures compliance charts was 870mm (area under curve (AUC): 0.65) (figure). Results of OCT parameters Univariate analysis P value Mean reference area 0.41 Pre % area stenosis 0.16 Calcium parameters Calcium arc 0.37 Calcium maximum thickness 0.04 Calcium area 0.20 Calcium longitudinal length 0.43 Conclusion A maximum calcium thickness

Background High sensitive cardiac troponin I (hs-TnI), subunit of cardiac troponin complex, is a sensitive and specific marker of myocardium injury as troponin T. Several studies showed hs-TnI was associated with worse cardiovascular outcomes but relationship between serum hs-TnI level in patients with atrial fibrillation (AF) after pulmonary vein isolation (PVI) and AF recurrence remains unclear. Methods We enrolled 444 consecutive AF patients who underwent PVI from May 2017 to September 2018. We investigated the difference of relationship between serum hs-TnI, inflammation markers at 48 hours after PVI and early or late recurrence of AF (ERAF, Results RFA and CBA were performed in 328 and 116 patients, respectively. There were no significant differences in patient characteristics between RFA group and CBA group. Serum hs-TnI in RFA group was significantly lower than in CBA group (1.93 ng/ml±3.28 vs 5.08 ng/ml±4.29, p TnI and CRP between RFA and CBA RFA (n=328) CBA (n=116) P value hs-TnI 1.93±3.28 5.08±4.29 Conclusion CBA may cause more myocardial injury than RFA, on the contrary RFA may cause more inflammation than CBA. These markers did not affect ERAF and LRAF after PVI.

To investigate whether lower extremity muscle activation patterns differ in the strides leading to locomotive state transitions in the involved limb of individuals with transtibial amputation. It is hypothesized that all transitions elicit activation differences between strides as the subjects move toward the transition event.Single-sample, observational study.University research center.Volunteer sample of persons with unilateral transtibial amputation (N=9; mean age, 48.8±12.1y; mean height, 1.74±0.09m; mean weight, 86.1±24.7kg) were recruited by posting flyers in local prosthetics clinics.Not applicable.Surface electromyography was used to measure muscle activation from 7 muscles of the involved limb. Subjects walked across 8 different terrain conditions transitioning from level-ground to ramp/stair locomotion and vice versa. Statistical Parametric Mapping analysis of variance (α.05) was used to assess muscle activation differences in the 3 pretransition gait cycles as subjects moved toward the terrain change.No muscle activation changes were observed in ramp transitions. All stair transitions elicited a myoelectric difference in at least 2 muscles. The transition from stair descent to level ground elicited change in the greatest number of muscles. Tibialis anterior activation was unchanged in all transitions.Muscle activation differences were observed in the involved limb of individuals with transtibial amputation during stair transitions, suggesting that those patterns may be successfully used in transition detection algorithms. It remains unknown whether ramp transitions can be successfully identified pretransition using electromyography.

Supplemental material, Supplemental Material1 for Factors predictive of long-term mortality in lupus nephritis: a multicenter retrospective study of a Japanese cohort by K Ichinose, M Kitamura, S Sato, K Fujikawa, Y Horai, N Matsuoka, M Tsuboi, F Nonaka, T Shimizu, S Fukui, M Umeda, T Koga, S Kawashiri, N Iwamoto, M Tamai, H Nakamura, T Origuchi, T Nishino and A Kawakami in Lupus

It has been reported that a phenomenon called “surgical diabetes”, which is a temporary hyperglycemic condition, occur due to anesthetic action during surgery. Surgical diabetes has been thought to be caused by the suppression of insulin secretion due to a decrease in glucose uptake. However, recent reports showed that insulin secretion is not inhibited by the low concentration of volatile anesthetic isoflurane used for treatments; though inhibition of glucose uptake occurred. Nevertheless, the cause of this has not yet been fully elucidated. In this study, we aim to verify that a change in membrane fluidity of insulin receptor (IR) causes surgical diabetes. Therefore, we have constructed a laminar flow live imaging system using a microfluidic device. The system control drug exposure within the observation system by creating a laminar flow in the cell culture place using MEMS technology. First, we formed laminar flow while observing on the stage of the confocal microscope. Furthermore, we succeeded in peeling cells which cultured in the device flow path, only in arbitrary region by trypsin treatment. Then, in order to elucidate the above phenomenon, we have investigated the effect of IR membrane diffusion was measured by the FRAP method. The result showed that the membrane fluidity of IR is enhanced during isoflurane treatment.It has been reported that a phenomenon called “surgical diabetes”, which is a temporary hyperglycemic condition, occur due to anesthetic action during surgery. Surgical diabetes has been thought to be caused by the suppression of insulin secretion due to a decrease in glucose uptake. However, recent reports showed that insulin secretion is not inhibited by the low concentration of volatile anesthetic isoflurane used for treatments; though inhibition of glucose uptake occurred. Nevertheless, the cause of this has not yet been fully elucidated. In this study, we aim to verify that a change in membrane fluidity of insulin receptor (IR) causes surgical diabetes. Therefore, we have constructed a laminar flow live imaging system using a microfluidic device. The system control drug exposure within the observation system by creating a laminar flow in the cell culture place using MEMS technology. First, we formed laminar flow while observing on the stage of the confocal microscope. Furthermore, we succeeded in pee...

Supplemental material, LUP881200 Supplemental Material for Factor Xa inhibitors for preventing recurrent thrombosis in patients with antiphospholipid syndrome: a longitudinal cohort study by T Sato, H Nakamura, Y Fujieda, N Ohnishi, N Abe, M Kono, M Kato, K Oku, T Bohgaki, O Amengual, S Yasuda and T Atsumi in Lupus

We present the electronic and structural properties of monolayer ${\mathrm{WSe}}_{2}$ grown by pulsed-laser deposition on monolayer graphene (MLG) on SiC. The spin splitting in the ${\mathrm{WSe}}_{2}$ valence band at $\overline{\mathrm{K}}$ was ${\mathrm{\ensuremath{\Delta}}}_{\mathrm{SO}}=0.469\ifmmode\pm\else\textpm\fi{}0.008$ eV, as determined by angle-resolved photoemission spectroscopy. Synchrotron-based grazing-incidence in-plane x-ray diffraction (XRD) revealed the in-plane lattice constant of monolayer ${\mathrm{WSe}}_{2}$ to be ${a}_{{\mathrm{WSe}}_{2}}=3.2757\ifmmode\pm\else\textpm\fi{}0.0008$ \AA{}. This indicates a lattice compression of $\ensuremath{-}0.19$% relative to bulk ${\mathrm{WSe}}_{2}$. By using the experimentally determined graphene lattice constant (${a}_{\mathrm{MLG}}=2.4575\ifmmode\pm\else\textpm\fi{}0.0007$ \AA{}), we found that a $3\ifmmode\times\else\texttimes\fi{}3$ unit cell of the slightly compressed ${\mathrm{WSe}}_{2}$ is perfectly commensurate with a $4\ifmmode\times\else\texttimes\fi{}4$ graphene lattice with a mismatch below 0.03%, which could explain why the monolayer ${\mathrm{WSe}}_{2}$ is compressed on MLG. From XRD and first-principles calculations, we conclude that the observed size of strain will affect ${\mathrm{\ensuremath{\Delta}}}_{\mathrm{SO}}$ only on the order of a few meV. In addition, angle-resolved, ultraviolet, and x-ray photoelectron spectroscopies shed light on the band alignment between ${\mathrm{WSe}}_{2}$ and MLG/SiC and indicate electron transfer from graphene to the ${\mathrm{WSe}}_{2}$ monolayer. As further revealed by atomic force microscopy, the ${\mathrm{WSe}}_{2}$ island size depends on the number of carbon layers on top of the SiC substrate. This suggests that the epitaxy of ${\mathrm{WSe}}_{2}$ favors the weak van der Waals interactions with graphene, while it is perturbed by the influence of the SiC substrate and its carbon buffer layer.

Reproducing the electronic structure of AM$_4$X$_8$ lacunar spinels with a breathing pyrochlore lattice is a great theoretical challenge due to the interplay of various factors. The character of the M$_4$X$_4$ cluster orbitals is critically influenced by the Jahn-Teller instability, the spin-orbit interaction, and also by the magnetic state of the clusters. Consequently, to reproduce the narrow-gap semiconducting nature of these moderately correlated materials requires advanced approaches, since the strength of the inter-cluster hopping is strongly affected by the character of the cluster orbitals. In order to provide a solid experimental basis for theoretical studies, we performed broadband optical spectroscopy on a large set of lacunar spinels, with systematically changing ions at the A and M sites as well as the ligand (A=Ga, Ge, Al; M=V, Mo, Nb, Ta; X=S, Se). Our study covers the range of phonon excitations and also electronic transitions near the gap edge. In the phonon excitation spectrum a limited subset of the symmetry allowed modes is observed in the cubic state, with a few additional modes emerging upon the symmetry-lowering structural transition. All the infrared active modes are assigned to vibrations of the ligands and ions at the A sites, with no obvious contribution from the M-site ions. Concerning the electronic states, we found that all compounds are narrow-gap semiconductors ($E_\mathrm{g} = 130 - 350\,$meV) already in their room-temperature cubic state and their structural transitions induce weak, if any, changes in the band gap. The gap value is decreased when substituting S with Se and also when replacing $3d$ ions by $4d$ or $5d$ ions at the M sites., Comment: 11 pages, 7 figures

We present the results of broadband dielectric spectroscopy of GaMo$_4$S$_8$, a lacunar spinel system that recently was shown to exhibit non-canonical, orbitally-driven ferroelectricity. Our study reveals complex relaxation dynamics of this multiferroic material, both above and below its Jahn-Teller transition at T$_{\textrm{JT}}=47$ K. Above T$_{\textrm{JT}}$, two types of coupled dipolar-orbital dynamics seem to compete: relaxations within cluster-like regions with short-range polar order like in relaxor ferroelectrics and critical fluctuations of only weakly interacting dipoles, the latter resembling the typical dynamics of order-disorder type ferroelectrics. Below the Jahn-Teller transition, the onset of orbital order drives the system into long-range ferroelectric order and dipolar dynamics within the ferroelectric domains is observed. The coupled dipolar and orbital relaxation behavior of GaMo$_4$S$_8$ above the Jahn-Teller transition markedly differs from that of the skyrmion host GaV$_4$S$_8$, which seems to be linked to differences in the structural distortions of the two systems on the unit-cell level.

ISPOR Europe 2018；2018.11.10-14；Barcelona, Spain

In the midst of global climate change, a large typhoon has hit Japan and unprecedented heavy rainfall is occurring. In large cities in Japan, underground discharge channels and underground regulating reservoirs are being developed to improve the flood control safety. In this paper, we confirm the flood reduction effect of these underground facilities against the rainfall generated by Typhoon Hagibis in the Tokyo area in 2019. In addition, the advantages of underground regulating reservoirs in the metropolitan area are discussed from two aspects: cost and land acquisition. It is confirmed that the underground reservoir type has remarkable advantages in both aspects.

A lot of devices measuring the International Roughness Index (IRI) has recently been developed and applied in response to the pavement inspection purposes. Consequently, the accuracy of measured IRIs obtained with different devices on the same road surface has become a practical concern for providing a consistent inspection result. Against this background, the specified non-profit organization Pavement Diagnosis Researchers Group (PDRG) in Japan has undertaken a project regarding the experiment to harmonize and compare Test methods for surface Roughness Under actual road Environment (TRUE project) since 2014. The TRUE project has so far conducted the roughness measuring experiments three times over five years at Hokkaido, Japan. This paper introduces the features of the TRUE project such as participated devices, test site selection, and data recording and reporting procedures. A benchmark testing for obtaining reference profiles is also provided to make the project reliable. In this paper, the results of experiments conducted in the last five years are statistically described as well. Finally, this paper introduces the potential of the TRUE project such as a new device grouping and the accuracy evaluation report for device certification for contributing to further improvement of a device participated in the project.

In this study, the effects of carbon fiber orientations on the strengthening of small-scale thin-walled steel cylinders (TSCs) under axial compression were experimentally and numerically investigated. Besides, the strengthening effects of various types of carbon fiber reinforced polymers (CFRPs) on the load-carrying capacity of full-scale TSCs were numerically investigated. The results showed that circumferential CFRP layers (0°) have significant effects on the increased load-carrying capacity of TSCs under axial compression, whereas, only 90° CFRP layers had small strengthening effects for TSCs under axial compression. When the TSCs subjected to bending shear loads with high values of internal pressures, the appearances of circumferential fibers also brought better strengthening effects than only the angled fibers for TSCs.

Spectral unmixing of hyperspectral data often fails to select some minerals and rocks having flat spectra but no diagnostic absorption features as endmembers, even if they are actually important endmembers. To avoid this problem, we propose a novel approach that combined two methods: spectral unmixing and full-pixel classification. First, all pixels were divided into two categories, hydrothermally altered areas and unaltered rocks based on the absorption depth of 2.0 to 2.5 μm. For the hydrothermally altered areas, endmembers were extracted by the Improved Causal Random Pixel Purity Index (ICRPPI) method, which was improved from the existing Pixel Purity Index (PPI) and Causal Random Pixel Purity Index (CRPPI) methods. Endmember abundance in each pixel was calculated by linear spectral unmixing. In a separate operation, k-means clustering was applied to the unaltered rock areas. Finally, the results of these two methods were combined to generate a single distribution map of rocks and minerals. This approach was applied to the airborne hyperspectral HyMap data of Cuprite, Nevada, U.S.A. We confirmed that our mapping result was consistent with the existing geological map as well as our field survey result.

We analyze the advantages of an electro-optic (EO) polymer/TiO2 vertical slot waveguide modulator based on a low-index EO polymer (SEO125). This modulator can realize a lower half-wave voltage (Vπ)-electrode length (Le) product (VπLe) when compared with hybrid EO polymer (EOP)/sol–gel silica waveguide modulators because of the high mode confinement of the guided light and the high poling efficiency. We show the enhancement of the poling efficiency in these devices when the EO polymers are poled with TiO2 and sol–gel silica layers. We also enhance the EO coefficient to a level of 260 pm/V at a wavelength of 1.31 μm for a high-index EOP (SEO100) deposited on TiO2, a sol–gel silica cladding layer, and an additional interfacial layer.

A dynamic smoothing method was proposed based on a phase control to stabilize plasma instabilities and smooth plasma non-uniformities. In this paper, the dynamic smoothing method is applied to a spherical fuel target implosion in heavy ion inertial fusion (HIF). We found that the wobbling motion of each heavy ion beam (HIB) axis induces a phase-controlled HIBs energy deposition, and consequently the phase-controlled implosion acceleration is realized, so that the HIBs illumination non-uniformity is successfully smoothed. HIB accelerators provide a well-established capability to oscillate the HIBs axes with a high frequency. In inertial confinement fusion, a fuel implosion uniformity is essentially important to compress the DT fuel and release the fusion energy, and the non-uniformity of the implosion acceleration should be less than a few %. The results in this paper also demonstrate that the wobbling HIBs would provide an improvement in the fusion energy output gain.

Paddy fields are an important source of atmospheric CH4, the second most important greenhouse gas. There is a strong concern that the increasing atmospheric CO2 concentration ([CO2]) and global warming are further stimulating CH4 emissions, but the magnitude of this stimulation varies substantially by study, and few open-field evaluations have been conducted. Here we report results obtained at a Japanese rice free-air CO2 enrichment (FACE) site under water and soil temperature elevation during two growing seasons. Our objectives were to evaluate the effects of high [CO2] (ambient + 200 μmol mol−1) and elevated soil temperature (+ 2 °C) on CH4 emissions under completely open-field conditions. We found about 80% enhancement in total seasonal emissions by the additive effects of FACE and warming, indicating a strong positive feedback effect of global warming. The enhancement in CH4 emission from the FACE-effect alone (+ 26%) was statistically non-significant (P = 0.19). Nevertheless, observed positive correlations between CH4 emissions and rice biomass agreed well with previous studies, suggesting that higher photosynthesis led to greater rhizodeposition, which then acted as substrates for methanogenesis. Soil warming increased the emission by 44% (P < 0.001), which was equivalent to a Q10 of 5.5. Increased rice biomass by warming could only partly explain the enhanced CH4 emissions, but stoichiometric analysis of the electron budget indicated that even a moderate enhancement in organic matter decomposition due to soil warming can cause a large increase in CH4 production under conditions where Fe(III) reduction, which was little affected by soil warming, dominates electron-accepting processes. At later rice growth stages, advanced root senescence due to elevated temperature probably provided more substrate for methanogenesis. Our stoichiometric evaluation showed that in situ Fe reduction characteristics and root turnover in response to elevated temperature should be understood to correctly predict future CH4 emissions from paddy fields under a changing climate. Challenges remain for determination of in situ root-exudation rate and its response to FACE and warming.

A flow, module steps and key structural elements enabling a surrounding gate transistor (SGT) based 6T-SRAM with 50nm pillar pitch and 0.0205 um2 are presented, with emphasis on process challenges and innovations. A new DTCO/TCAD methodology is used to explore the design space, demonstrate the bit cell functionality and optimize the process. In particular, it is shown that vertical SGT are extremely sensitive to gate misalignment and that buried bottom contact makes the process immune to doping variations and misalignments.

Background The levels of corneal donation are insufficient to meet the demand for corneal transplantation in Japan. To overcome this problem, we started to routinely mention the possibility of corneal donation to the families of patients who died in our hospital's Urology Department in February 2008. In this study, we evaluated the effectiveness of this approach. Methods We retrospectively reviewed the medical records of the patients who died in the Department of Urology, St. Marianna University School of Medicine Hospital, and analyzed the patients' characteristics and information about corneal donation. Results In total, 211 patients died in our department between February 2008 and March 2017, and 155 patients were medically suitable corneal donors. We mentioned the possibility of corneal donation to 129 (83.2%) families, and 29 (18.7%) families agreed. Three families subsequently withdrew their consent. Finally, 26 (16.8%) of the families that were approached about corneal donation by urologists agreed to donate their relatives' corneas. Another 2 families voluntarily offered to donate their relatives' corneas. Thus, 28 (18.1%) of 155 medically suitable donors donated their corneas for transplantation. Twenty-six (92.8%) donors were 60 years or older and all donors were affected with malignant genitourinary tumors. Fifty-four (96.4%) corneas were successfully transplanted into recipients. Conclusions Even elderly patients who die of solid carcinoma can be an important source of corneal donors. In this study, we showed that routine referral by urologists increased corneal donation. If this approach were adopted by other departments, it might further increase the number of corneal donations.

To specify preferential occupation sites of Co substituents and to clarify charge and spin states of Co ions in (La, Co)-cosubstituted hexagonal magnetoplumbite-type (M-type) Sr ferrite ${\mathrm{Sr}}_{1\ensuremath{-}x}{\mathrm{La}}_{x}{\mathrm{Fe}}_{12\ensuremath{-}y}{\mathrm{Co}}_{y}{\mathrm{O}}_{19}$ ($x,y\ensuremath{\le}0.4$), $^{57}\mathrm{Fe}$ and $^{59}\mathrm{Co}$ nuclear magnetic resonance (NMR) spectra are measured under zero and external magnetic fields using powdered and single crystalline specimens. For comparison, NMR investigations of nondoped and La- or Co-doped M-type Sr ferrites are also performed. Ferrimagnetic M-type Sr ferrite contains the following five crystallographic Fe sites: the majority spin sites $12k$, $2a$, and $2b$, and the minority spin sites $4{f}_{1}$ and $4{f}_{2}$. Based on $^{57}\mathrm{Fe}$ and $^{59}\mathrm{Co}$ NMR, a plausible model of (La, Co)-codoped Sr ferrite is deduced. To a considerable degree, the charge compensation between ${\mathrm{La}}^{3+}$ and ${\mathrm{Co}}^{2+}$ works in the equal (La, Co)-codoped case, where more than half of the Co ions are considered to be present in the minority spin $4{f}_{1}$ sites at the center of the oxygen tetrahedra, with the $S=3/2$ state carrying a small orbital moment owing to spin-orbit interaction. The remaining small number of high-spin ${\mathrm{Co}}^{2+}$ ($S=3/2$, $L=1)$ ions with unquenched orbital moments would be distributed to the other octahedral $12k$, $2a$, and $4{f}_{2}$ sites.

The presence of both inversion (P) and time-reversal (T) symmetries in solids leads to a double degeneracy of the electronic bands (Kramers degeneracy). By lifting the degeneracy, spin textures manifest themselves in momentum space, as in topological insulators or in strong Rashba materials. The existence of spin textures with Kramers degeneracy, however, is difficult to observe directly. Here, we use quantum interference measurements to provide evidence for the existence of hidden entanglement between spin and momentum in the antiperovskite-type Dirac material Sr3SnO. We find robust weak antilocalization (WAL) independent of the position of EF. The observed WAL is fitted using a single interference channel at low doping, which implies that the different Dirac valleys are mixed by disorder. Notably, this mixing does not suppress WAL, suggesting contrasting interference physics compared to graphene. We identify scattering among axially spin-momentum locked states as a key process that leads to a spin-orbital entanglement., The spin texture in presence of both inversion and time-reversal symmetries has been difficult to observe. Here, Nakamura et al. report evidence of hidden entanglement between spin and momentum in antiperovskite Dirac material Sr3SnO.

This study aimed to evaluate neuromuscular activation in the scalene and sternocleidomastoid muscles using surface electromyography (EMG) during progressively increased inspiratory flow, produced by increasing the respiratory rate under inspiratory-resistive loading using a mask ventilator. Moreover, we attempted to identify the EMG inflection point (EMGIP) on the graph, at which the root mean square (RMS) of the EMG signal values of the inspiratory muscles against the inspiratory flow velocity acceleration abruptly increases, similarly to the EMG anaerobic threshold (EMGAT) reported during incremental-resistive loading in other skeletal muscles. We measured neuromuscular activation of healthy male subjects and found that the inspiratory flow velocity increased by approximately 1.6-fold. We successfully observed an increase in RMS that corresponded to inspiratory flow acceleration with ρ ≥ 0.7 (Spearman’s rank correlation) in 17 of 27 subjects who completed the experimental protocol. To identify EMGIP, we analyzed the fitting to either a straight or non-straight line related to the increasing inspiratory flow and RMS using piecewise linear spline functions. As a result, EMGIP was identified in the scalene and sternocleidomastoid muscles of 17 subjects. We believe that the identification of EMGIP in this study infers the existence of EMGAT in inspiratory muscles. Application of surface EMG, followed by identification of EMGIP, for evaluating the neuromuscular activation of respiratory muscles may be allowed to estimate the signs of the respiratory failure, including labored respiration, objectively and non-invasively accompanied using accessory muscles in clinical respiratory care.