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Objective: This study aims to explore the trajectory of sexual dysfunction (FSD) in breast cancer patients up to 9 months after diagnosis and to analyze factors influencing the trajectory. Methods: A longitudinal study was used to investigate 225 patients with a first diagnosis of breast cancer in a tertiary care hospital in Sichuan. Patients were dynamically assessed with the Female Sexual Function Index (FSFI) at baseline, 1 month after diagnosis (T1), 3 months after diagnosis (T2), 6 months after diagnosis (T3), and 9 months after diagnosis (T4). Results: The incidence of FSD in breast cancer patients at each follow-up time point in this study was 30.7%（T0), 80.4%(T1), 81.8%(T2), 87.5%(T3), and 78%(T4), with the greatest severity of FSD at T3. The trajectory of FSD development in the 3 groups of trajectories was the optimal model, accounting for the "FSD improvement group" (22.9%), "FSD severe group" (56.1%), and "FSD worsening group" (21%). Age less than 40 years (β=2.811, P=0.048), occupation as cadre and professional (β=1.740, P=0.033), pre-treatment poorer sexual arousal (β=-2.625, P=0. 011), poorer sexual satisfaction (β=-1.555, P=0.033), and higher sexual pain (β=-1.465, P=0.032) were influencing factors for the "FSD severe group". Chemotherapy cycles ≥8 cycles (β=-1.274, P=0.040), cadre and professional occupation (β=2.172, P=0.009) were the influencing factors in the "FSD worsening group". Conclusion: Early detection of those at risk for FSD is advised for effective intervention due to the high incidence of FSD in breast cancer patients during treatment and the inability of sexual function to return to pretreatment levels at month nine of treatment. Trajectory analysis revealed that the trajectory of FSD development in breast cancer patients showed a large heterogeneity, suggesting that clinical interventions should be tailored to the individual. Priority treatment targets for intervention included patients who were under 40, ≥8 cycles of chemotherapy, professionals, low levels of pre-treatment sexual arousal and sexual satisfaction, and high levels of pre-treatment sexual pain.

Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal-organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.

Whey proteins are mainly a group of small globular proteins. Their structures can be modified by physical, chemical, and other means to improve their functionality. The objectives of this study are to investigate the effect of radiation on protein–protein interaction, microstructure, and microbiological properties of whey protein–water solutions for a novel biomaterial tissue adhesive. Whey protein isolate solutions (10%, 27%, 30%, 33%, and 36% protein) were treated by different intensities (10–35 kGy) of gamma radiation. The protein solutions were analyzed for viscosity, turbidity, soluble nitrogen, total plate count, and yeast and mold counts. The interactions between whey proteins were also analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis and scanning electron microscopy. The viscosity of protein solution (27%, w/w) was increased by the treatment of gamma radiation and by the storage at 23 °C. The 35 kGy intensity irradiated soluble nitrogen (10%, w/w) was reduced to about half of the sample treated by 0 kGy gamma radiation. The effects of gamma radiation and storage time can significantly increase the viscosity of whey protein solutions (p < 0.05). Radiation treatment had significant impact on soluble nitrogen of whey protein solutions (p < 0.05). SDS-PAGE results show that the extent of oligomerization of whey protein isolate solutions are increased by the enhancement in gamma radiation intensity. Photographs of SEM also indicate that protein–protein interactions are induced by gamma radiation in the model system. Consistent with above results, the bonding strength increases by the addition of extent of gamma radiation and the concentration of glutaraldehyde. Our results revealed that the combination of gamma-irradiated whey protein isolate solutions and glutaraldehyde can be used as a novel biomaterial tissue adhesive.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has a poor prognosis. Cuproptosis is a novel mode of cell death that has only recently been discovered. Considering the critical role of lncRNAs in liver cancer development, the aim of this study was to construct a prognostic signature based on cuproptosis-related lncRNAs (CRlncRNAs). We downloaded RNA-sequencing data and corresponding clinical information of patients with HCC from The Cancer Genome Atlas (TCGA) database. To verify the robustness of the model, we added an external validation set obtained from the Gene Expression Omnibus (GEO): GSE40144. In addition, we identified the cuproptosis-related genes (CRGs) based on previous reports. Pearson correlation analysis, univariate Cox regression, and least absolute shrinkage and selection operator (LASSO) Cox regression analysis were utilized to screen for genes associated with prognosis. On this basis, multivariate Cox regression and stepAIC were used to further construct and optimize the prognostic model. The simplified signature with the lowest Akaike information criterion (AIC) value was considered the prognostic signature. Seven different algorithms were used to perform immune infiltration analysis. The single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm was utilized to find the difference in immune function between the high- and low-risk groups. Finally, in vitro experiments were performed by quantitative real-time PCR (qRT–PCR) analysis using HCC cell lines to validate the expression of prognostic genes. We identified 3 lncRNAs (CYTOR, LINC00205, and LINC01184) as independent risk factors for HCC. The receiver operating characteristic (ROC) curves calculated that the AUC at 1, 3, and 5 years reached 0.717, 0.633, and 0.607, respectively. The expression levels of 41 immune checkpoints differed significantly between the high- and low-risk groups, and there were significant differences in sensitivity to immunotherapy between the high- and low-risk groups. The risk model could also serve as a promising predictor of immunotherapeutic response, which has been verified by the TIDE algorithm ( p < 0.001 ). Overall, we propose a signature related to CRlncRNAs that can be used to predict the prognosis of HCC patients, which was validated in external cohort and in vitro experiments.

Y443 packer is widely used in staged fracturing of horizontal wells, but the packing element is often damaged by shoulder extrusion, and the spacer ring has a close relationship with the formation of shoulder extrusion. Therefore, in order to decrease the influence of shoulder extrusion on the sealing performance and service life of the compression packer, this manuscript studies the influence of the spacer ring on the sealing performance of the packing element and optimizes the structural parameters of the spacer ring used in a Y443 packer. Firstly, the finite element model of Y443 packer is established. Then, combine response surface method with finite element results, three response surface equations and response surface model are obtained. Finally, three response surface equations are solved to obtain optimal parameters of the spacer ring. The results show that finite element model can accurately simulate the sealing process. The response surface model has good adaptability and can meet the evaluation index, which indicates that the fitting equations have good performance and reliability. Through multi-objective optimization, the best structural parameters of the spacer ring are proposed, whose $$\theta 1,\theta 2$$ and h are 30°, 30° and 6 mm, respectively. Furthermore, the spacer ring can choose pentagon structure. This research provides a reference for the structural design of spacer rings to improve sealing performance of Y443 packers, and it is of great significance for oil and gas exploitation.

Natural Gas Hydrate (NGH) downhole hydrocyclone separator is one of the core components of solid-state fluidized mining method, and its adaptability to NGH reservoir parameters directly determines ...

Structured efficient and effective photocatalysts was crucial to improve photocatalytic efficiency. In this work, regular octahedron Cu-MOFs and Mn0.05Cd0.95S nanoparticles were adopted to constitute a S-scheme heterojunction. The Cu-MOFs/Mn0.05Cd0.95S (5 wt%) composite exhibited powerful photocatalytic hydrogen evolution activity of 547.5 μmol after 5 h under visible light irradiation (λ > 420 nm), which was ascribed to structure a S-scheme heterojunction brought great redox capacity and efficient separation and transfer of electrons and holes. The SEM and HRTEM results presented close contact of the Cu-MOFs and Mn0.05Cd0.95S. The PL, TRPL, and electrochemical properties further indicated that the composite photocatalysts had competent photocatalytic performance. The UV–vis DRS indicated that the composite catalyst had excellent light absorption capacity. It was confirmed that the composite photocatalysts owned excellent chemical stability by the XPS, FT-TR, and XRD. The S-scheme process can eliminate useless electrons and holes and provide more electrons to participate H2 evolution reduction. This work contributed new strategy to rational structure heterojunction photocatalysts for hydrogen evolution.

Transition metal layered double hydroxides (LDHs) with amazing theoretical capacitance have caused remarkable interest as a potential supercapacitor electrode materials. However, the exerted low performance limits their further application. Nano-engineering technology was considered to be an effective strategy to further expose the pseudocapacitive properties of materials. Here, an ordered NiV LDHs@P-NF nanoarray was successfully constructed via phosphorized pretreatment and hydrothermal growth method. The as prepared NiV LDHs@P-NF electrode delivers an areal capacitance of 2.85 F cm−2 at the current density of 20 mA cm−2 and rarely decrease capacitance after over 5000 cycles at 50 mA cm−2. Furthermore, the asymmetric supercapacitor assembled with prepared NiV LDHs@P-NF as the positive electrode and activated carbon as the negative electrode was found to show a maximum energy density of 0.202 mWh cm−2 under a power density of 7.022 mW cm−2. This work suggests that the NiV LDHs@P-NF nano-arrays electrode can be regard as the remarkable candidate to improve the performance of the asymmetric supercapacitor.

Perforating-test joint operation in oil&gas wells may causes strong impact vibration of downhole tools which can easily lead to buckling of tubing string, falling off of tools and damage of instruments. A 3D impact dynamic model of the perforated tubing string is established by using d'Alembert's principle and microelement method, and solved by the Newton difference method, taking into account the well trajectory, internal/external fluid pressure, interaction forces between the tubing and casing, and the coupling effect of perforating gun-shock absorber-tubing string. Due to the complexity of the verification, firstly, a similar experiment is carried out to test the accuracy of the model preliminarily. Secondly, through a case analysis, the feasibility of the model in the perforation impact dynamic analysis of tubing string in curved wells is further investigated. Both the two tests show that the model proposed in this paper has good calculation accuracy and can meet the needs of perforation shock vibration analysis of tubing string in curved wells perforation.

Today, the IT departments of many healthcare organizations are suffering from data storage and network speed. Doctors diagnose patients to help them out, and this treatment process needs to be well managed. Clinical trial data are the main basis for judging the patient’s condition in the medical process. With the rapid development of clinical laboratory technology in China, important achievements have been made in medicine. Clinical hospitals use a large number of different types of testing reagents and equipment, and the accuracy of testing data has become a key issue for testing results. The accuracy of testing data comes from the zero error of clinical testing, derived from the rigor and operational rigor of the testers in clinical testing. This article is dedicated to the quality control analysis and research based on mobile medical edge computing in clinical trials. This article introduces the relevant theories of mobile medical edge computing technology and quality control methods, with reference to the study on the general medical students’ clinical competency in problem-solving, communication skills, procedure, history, and physical examination and critical and non-critical indicators in objective structured clinical examination (OSCE). In addition, a routine testing group and a quality control group for strengthening important aspects of medical testing were designed to conduct comparative experiments. Experiments have proved that the quality control group for strengthening the important links of medical testing has a higher index than the routine testing group in all aspects. Among them, the detection accuracy rate can reach up to 99.48%, which is of great significance for the improvement of the detection link of the patient’s condition and the follow-up diagnosis and treatment link.

In this study, carboxyl-terminated polybutylene adipate (CTPBA) was used to modify epoxy resin, and the modified epoxy resin was cured by a room temperature rapid curing agent (T-31). The effects of CTPBA modification on bonding properties and mechanical properties of epoxy resin adhesive at room temperature were carefully studied. Epoxy-terminated prepolymer was synthesized by pre-polymerization and its structure was characterized. Compared with the addition method of direct blending, the bonding properties and mechanical properties of pre-polymerized epoxy resin adhesive were significantly better. Compared with unmodified epoxy resin, CTPBA modification significantly improved the bonding strength. Furthermore, with the increase of CTPBA content, the shear strength of the material increased first and then decreased, and reached the maximum when the addition amount was 40 phr. This shows that the tensile strength of the material decreased with the increase of CTPBA content, and the elongation at break increased with the increase of CTPBA content. Dynamic mechanical analyzer (DMA) test results showed that the addition of CTPBA reduced the glass transition temperature, but broadened the damping temperature range. TG analysis showed that the thermal stability of the modified epoxy resin was good, and compared with pure epoxy resin, the initial temperature of thermal weight loss and the maximum thermal decomposition rate decreased, but the overall thermal stability was not significantly different. In summary, CTPBA modification of epoxy resin is expected to improve the comprehensive mechanical properties at room temperature.

The hollow materials have stronger absorption capacity for visible light than other materials due to their special internal cavity structure. In this paper, NiTiO3 hollow nanorods and Co9S8 QDs wer...

Layered double hydroxides (LDHs) have been paid more attention in supercapacitors due to their advantages in structure and performance. In particular, NiCo LDHs have been extensively studied due to its high theoretical specific capacity. Unfortunately, the exerted capacity is much lower than the theoretical value due to its poor electron conductivity. In this work, P@NiCo LDHs cabbage-like spheres were successfully synthesized by a mild co-precipitation strategy and a subsequent phosphating treatment method. Owing to the generation of metal phosphides, which is endowed with good electron conduction ability, the specific capacitance of the P@NiCo LDHs (536 C g−1) is 1.88 times greater than the NiCo LDHs (285.8 C g−1) at a current density of 1 A g−1. In addition, the prepared electrode provided a good cycling performance with no difference from the initial capacitance at 10 A g−1 after 5000 cycles. Besides, the symmetric supercapacitor device with vacuum plastic packaging structure was prepared, which exhibits an energy density of 7.83 W h kg−1 at 300 W kg−1. This work indicates that the phosphating strategy is an effective way to improve the performance of LDH-based materials for supercapacitors.

The combination of large energy density and high power density is the optimized model for supercapacitors. However, due to the sluggish charge transfer and ion diffusion, cobalt-aluminium hydrotalcite (CoAl LDHs) electrode materials currently deliver barely satisfactory performance. Oxygen vacancies have been reported to have positive facilitation to the electrochemical property of the hydrotalcite-like materials. In this work, the proportion of oxygen vacancies in CoAl LDHs was increased by NaBH4 treatment, which improved the electrochemical energy storage performance of pristine CoAl LDHs, while prolonged treatment will damage the internal structure of the material and is not conducive to the improvement of electrochemical performance. Consequently, the acquired CoAl LDHs-0.5 delivers a high specific capacity of 799.2 F g−1 at a current density of 1 A g−1 and maintains 81.1% capacity as the current density up to 20 A g−1, which exhibited higher performance than pristine CoAl LDHs and the most reported CoAl LDH-based materials. Besides, the asymmetric supercapacitor (ASC) was fabricated using CoAl LDHs-0.5 and commercial activated carbon (AC) as the positive and negative electrodes, respectively, which exhibits a maximum energy density of 28.9 W h kg−1 at a power density of 523.5 W kg−1 and retains 73.3% of the initial capacity after 5000 cycles at a current density of 5 A g−1. This work provides an ingenious strategy and builds confidence in the further application of CoAl LDHs in electrode materials of supercapacitors.

Research on cheap co-catalysts to increase hydrogen evolution and improve catalyst stability is an important developmental direction in the field of photocatalytic hydrogen release. In this work, Mo15S19/CdS nanocomposites were synthesized via a facile multistep synthesis method. On account of the larger specific surface area, more active sites and more favorable photogenic carrier separation of the composite photocatalyst, the 5%-Mo15S19/CdS obtained the highest hydrogen production capacity. The rate reached 142.9 μmol h−1 (10 mg), which is 8.4 times that of the pristine CdS nanorods. The introduction of Mo15S19 can reduce the surface resistance and improve the transportation of photogenerated electrons on the surface of CdS, resulting in a significant reduction in the recombination rate of the photogenerated electrons, thereby promoting the photocatalytic hydrogen production performance of CdS. This work not only provides an effective co-catalyst to improve the rate of photocatalytic water splitting of CdS, but also provides a reference for the development of novel high efficiency catalysts.

Aphids are among the most destructive phytophagous pests of host plants, because of their rapid reproduction, parthenogenesis, extensive crop damage, and the transmission of many plant viruses. Since lady beetles are important predatory natural enemies of aphids, developing lady beetle attractants to increase their field abundance is vital for aphid control. Floral volatiles and other semiochemicals are reportedly attractive to lady beetles. In this research, a total of 58 floral volatiles were tested by Y-tube olfactometer assays, among which 29 were highly attractive to both Harmonia axyridis (Coleoptera: Coccinellidae) and Coccinella septempunctata (Coleoptera: Coccinellidae). Meanwhile, the results of wind tunnel trials showed that only isoamyl acetate, α-humulene, trans-3-hexen-1-ol, methyl salicylate, and β-pinene lure these two species. Thereafter, 15 semiochemicals from pests, natural enemies, and pest-infested crops were mixed with the selected floral volatiles, to determine optimum formulations for attracting lady beetles through wind tunnels and further field trials. Eventually, formulas (1) α-humulene: β-pinene: methyl salicylate: trans-3-hexen-1-ol = 1:3:3:10; (5) α-humulene: β-pinene: methyl salicylate:1-nonanal = 1:3:3:10; (8) α-humulene: β-pinene: methyl salicylate: indole = 1:3:3:10 (1, 5, and 8 are labels used for the various formulations in field trials) were successfully verified to be attractive to lady beetles in both pumpkin and wheat fields. These formulations will be of great significance in developing integrated pest management strategies for aphid control.

Metal-organic frameworks (MOFs) and layered double hydroxides (LDHs) have been considered to be one of the most promising and worthy hot-spot materials to develop advanced catalysts for efficient hydrogen evolution and energy storage because of their abundant diversity in structure and excellent properties. However, the design of heterogeneous structure is usually an effective tactic for the construction of efficient photocatalysts because it is difficult for a single material to meet the requirements of wide spectral light response and efficient charge separation. Here, the NiV LDH@ZIF-67 p-n heterojunction was synthesized by “bottle around ship” method and served as prominent photocatalyst for hydrogen evolution and excellent supercapacitor electrode as well. Delightedly, the prepared NiV LDH@ZIF-67 hybrid shows the most excellent photocatalytic H2 evolution rate with 9.5 and 5.9 times more than ZIF-67 and NiV LDH, respectively. Furthermore, the assembled asymmetric supercapacitor with active carbon exhibits a high energy density of 42.3 Wh kg−1 at a power density of 520.6 W kg−1 and 120% of energy storage retention after 5000 cycles (81.4% of NiV LDH//AC). This study demonstrates the promising potential of NiV LDH@ZIF-67 p-n junction for both the fields of photocatalysis and energy storage.

The intensive exploration to improve the accuracy of the calculation model of velocity slip and theoretical head has always been a major issue in pump research. Discontinuous blade of disc pump is different from the continuous blade of traditional pump. Disc pump realizes energy transfer by the effect of boundary layer. In order to fill in the theoretical blank of current research on the velocity slip and theoretical head of blade disc pump, the velocity slip is calculated by the systematic analysis under solid–liquid flow. In this study, the current misconception of velocity slip was corrected. Based on the different normal velocity components between particle and liquid on the blade surface, a new method is proposed to further verify the difference of solid–liquid flow velocity in impeller passage. Through the proposed method of calculating average circumferential velocity, the calculation model of the velocity slip coefficient and theoretical head of disc pump with linear and curved blade are given and verified. The accuracy of calculation model is increased by 39.4%. This model has good application value in theoretical head calculation, which lays a foundation for further research on energy conversion, energy efficiency prediction and reverse optimization design of disc pump with different blade shapes.

Improving conductivity of electron and ion was considered to be the significant tendency on pseudocapacitive materials. In this work, a flower-like P-NiAl LDHs electrode materials have been successfully fabricated by hydrothermal synthesis and subsequent phosphatized treatment. Owing to the presence of phosphide, the resulting P-NiAl LDHs electrode showed a high specific capacitance of 2159F g−1 at 1 A g−1 and a good capacitance retention of 85.6% at 20 A g−1, which more excellent than NiAl LDHs electrode. Besides, the P-NiAl LDHs//AC asymmetric supercapacitor exhibited a high energy density of 79.3 Wh kg−1 under a power density of 1033.6 W kg−1 and an acceptable stability of 73.6% specific capacitance retention after 2400 charge-discharge cycles. Consequently, the P-NiAl LDHs nanoflower is one of the better candidates for assembling supercapacitor, and this phosphatized method is a kind of facile and desirable strategies to improve the electrochemical characteristics of LDH-based supercapacitor materials.

In this work, p-type semiconductor CoWO4 nanoparticles was successfully anchored on the surface of n-type Mn0.2Cd0.8S nanorods, and p-n type heterostructure photocatalysts with low cost and high efficiency were synthesized. By optimizing the loading of CoWO4 nanoparticles, the hydrogen evolution rate of the compound can reach a maximum, the peak is 408 μmol/5 h. Under visible light irradiation, it is equivalent to 3.61 times pure Mn0.2Cd0.8S. In addition, the composite catalyst has favorable durability and structural stability. In terms of morphology, the combination of nanorods (SBET = 24 m2g-1) and nanoparticles (SBET = 12 m2g-1) increased the specific surface area of the composite catalyst (SBET = 31 m2g-1), thus the composite exposed more active sites. In terms of heterojunction, the conduction bands of two semiconductors were determined by UV–vis diffuse reflection and Mott-Schottky, and the construction of p-n heterojunction was verified. The results of photochemical experiment further indicate that the built-in electric field in the p-n type heterostructure not only accelerates the electron-hole pair transfer, but vastly enhances the carrier average lifetime. In this paper, the morphology of the photocatalyst was modified and p-n heterojunction was constructed. The result is that the performance of Mn0.2Cd0.8S MCS was improved and the possible mechanism of photocatalytic hydrogen evolution was proposed.

One of the urgent problems that has yet to be addressed in the field of drilling engineering is how to further improve the working performance of rock bit journal bearings (RBJBs) and prolong their...

Hydrogen production from water splitting is considered as a brand-new and promising way to convert solar energy into recyclable chemical energy. Herein, a core–shell-shaped structure which consisted of Mn0.05Cd0.95S nanorods and flowerlike NiAl-LDH microsphere was constructed via a simple hydrothermal method. The constructed Mn0.05Cd0.95S/ NiAl-LDH core–shell-shaped structure shows superior photocatalytic H2 evolution. The highest photocatalytic H2 evolution rate of the composite is 7.5 mmol g−1 h−1, which is 17 and 6 times higher than those of NiAl-LDH and Mn0.05Cd0.95S respectively. The core–shell like structure is beneficial for the H2 production reaction because NiAl-LDH flowerlike microsphere can provide large surface for the anchoring of Mn0.05Cd0.95S nanorods, which can enhance the interaction between these two materials. A series of characterizations including XRD, FT-IR, SEM, TEM, BET, XPS, UV−vis DRS, etc., were conducted and studied to analyze the reason for the enhanced photocatalytic hydrogen evolution activity. The results of XPS show that an interaction between NiAl-LDH and Mn0.05Cd0.95S has been occurred. The interaction between these two materials is presented through the transfer of electrons, which can be demonstrated by the results of XPS. And, it is found that the rational designed structure can accelerate the transfer of electrons and this is the reason for the enhanced photocatalytic evolution performance. A core-shell like structure consisted of Mn0.05Cd0.95S nanorods and NiAl-LDH nanoflower like sphere was designed rationally via a simple method. The NiAl-LDH nanoflower like sphere with some wrinkles on its surface can provide more areas to contact with Mn0.05Cd0.95S nanorods, which can is beneficial for the interaction between these two materials and accelerate the transfer of electrons.

The wrap angle is one of the key parameters in design of impeller and space diffuser. At present, it is mainly designed based on theoretical estimation and experience. However, there are few studies on collaborative design. In this paper, the process model of collaborative design was put forward, then 25 kinds of wrap angle matching schemes between impeller and space diffuser were determined by orthogonal experimental method, and it was completed to study basic change law of the external characteristics and flow field under different matching schemes. It was shown that impeller wrap angle had more obvious influence on the hydraulic characteristics than space diffuser wrap angle within a certain wrap angle range. Therefore, the optimal impeller wrap angle should be determined in the collaborative design at first. By the multidimensional evaluation criteria, it was carried out such as the selection of the space diffuser wrap angle. It can reduce a lot of work to easily find a better balance about multi-influence of the multi-component parameters, and get an optimal performance when the diagonal-flow pump is used in oil and gas development.

The surface modification of titanium is effective in promoting osseointegration and is widely used in the treatment of bone diseases. Epimedii Folium (EF) plays an important role in the treatment of metabolic bone diseases. However, few studies have so far been reported on their combined use in such treatments. In the present study, EF water extract was coated onto the surface of TiO2 nanotubes (TNT) by electrochemical anodization to obtain EF-TNT. Through analysis of surface morphology characteristics, it was demonstrated that EF was successfully coated on the surface of TiO2 nanotubes. In vitro drug release data suggested that the quantity of EF water extract released was a significant quantity over 4 days, reaching a total of 80%, the release continuing in total for approximately 2 weeks. By using scanning electron microscopy and immunofluorescent staining, it was found that, EF-TNT more strongly promoted adhesion, proliferation, and differentiation of MC3T3-E1 osteoblasts compared with Ti and TNT. Quantitative reverse transcript polymerase chain reaction (qRT-PCR) analysis indicated that the expression of key genes for proliferation and differentiation of osteoblasts, such as COL1a1, ALP, OPN, and Runx2, were up-regulated by EF-TNT. Network pharmacology analysis suggested that EF water extract not only regulated the proliferation and differentiation of osteoblasts but also caused a regulatory effect on osteoclasts via multiple signaling pathways, such as RANKL-RANK-induced signaling and TGF-β signaling. These findings indicate that the EF-TNT promotes differentiation and proliferation of osteoblasts, and represents considerable potential for use in clinical applications.

Fluid-induced vibration (FIV) prediction is an important prerequisite work in wear and fatigue analysis of tubing string in oil & gas well. The finite element method, energy method and Hamiltonian principle are comprehensively used to establish a single nonlinear vibration model of pipe conveying fluid, taking into account the longitudinal/lateral coupled vibration. Based on the contact/impact theory of elastic/plastic body, the nonlinear contact-impact model of tubing-casing is established and introduced into the single nonlinear vibration model to form a bi-nonlinear vibration model of tubing string in oil & gas well. The bi-nonlinear model is numerically discretized by the finite element method, solved by Newmark− β method, and verified preliminarily by a classical contact/impact example in literature in which the influence of inflow is not taken into account temporarily. A similar experiment of tubing vibration is designed and completed to further test the validity of the bi-nonlinear vibration model by comparing the frequency-domain and time-domain responses of the experiment with those from the model. The analysis shows that the bi-nonlinear model has good calculation accuracy and the vibration response law is basically consistent with the experimental results, which can provide an effective theoretical analysis tool for FIV behavior of tubing string in oil & gas well.

This study investigated the effect of microbial transglutaminase cross-linking on the gel properties of soybean-whey mixed protein (SPI-WPI) after ultrasonic pretreatment. The average particle size of SPI-WPI decreased with increasing of ultrasonic time treatment, and minimal particle size was verified after 45 min. Endogenous fluorescence spectroscopy and surface hydrophobicity analysis showed that the SPI-WPI conformation changed after ultrasonic treatment. The polypeptide chain partially expanded inside the protein molecule, the hydrophobic group was exposed, and the protein structure became more stretched. The gel hardness and water holding capacity of the SPI-WPI hybrid system reached a maximum 30 min after ultrasonic treatment. Fourier infrared analysis showed that the secondary structure of the protein changed after ultrasonic modification. A complex is formed between SPI and WPI, and the gel properties of the mixed protein are significantly improved, providing theoretical and technical support for the development of new mixed protein foods.

Introduction: Obtaining central venous access is one of the most commonly performed procedures in cancer patients. However, there are very limited data to guide clinicians when selecting a device for metastatic colorectal cancer patients who received cetuximab. Case description: A 54-year-old male patient with metastatic colorectal cancer treated with cetuximab plus FOLFIRI used peripherally inserted central catheter as intravenous pathway. After eight cycles, the patient suffered cetuximab-induced grade 2 skin toxicity and grade 3 contact dermatitis at the peripherally inserted central catheter insertion site. Finally, he removed the peripherally inserted central catheter and accepted subcutaneous port instead for 2 years without implantation cutaneous complication. Conclusions: We suggest that metastatic colorectal cancer patients treated with cetuximab should be recommended to choose subcutaneous port preferentially to avoid potential risk of unexpected peripherally inserted central catheter removal due to cetuximab-induced skin toxicity or contact dermatitis. Further clinical practices and researches are needed for more profound evidences for better practical suggestions.

In this work, C@ZnxCd1-xS/Co3O4 catalyst which with high hydrogen production activity was prepared and the catalyst was characterized by SEM, TEM, XRD, XPS, Uv–vis DRS characterization. After two-step modification, the light absorption intensity of C@ZnxCd1-xS and C@ZnxCd1-xS/Co3O4 showed an increasing trend compared with pure ZnxCd1-xS, such phenomenon was beneficial to the visible light absorption and utilization of photocatalyst. In addition, Mott-Schottky proved that ZnxCd1-xS catalyst formed p-n heterojunction with Co3O4 nanoparticles, which further demonstrated that the modification of ZnxCd1-xS by Co3O4 was successful. And the hydrogen production of C@ZnxCd1-xS/Co3O4 (30%) (1405.1 μmol) was 6.9 times that of pure ZnxCd1-xS. The improvement of photocatalytic performance can be attributed to that carbon particles accelerate the storage and transfer of electrons, and the formation of p-n heterojunction between Co3O4 and ZnxCd1-xS promotes the separation of photogenerated carriers effectively. In this study, the introduction of amorphous carbon and Co3O4 promoted the transfer and separation of electrons and holes greatly, thereby inhibited the recombination of carriers and provided the favorable conditions for the preparation of highly efficient and stable photocatalysts.

Follicular thyroid carcinoma (FTC) is a common endocrine malignancy with highly aggressive features. In this study, next-generation sequencing technology was used to identify aberrant expression of sialyltransferase (ST) family members in FTC. Aberrant high expression of alpha-2,6-sialyltransferase 2 (ST6GAL2) was demonstrated to promote tumorigenesis of FTC in vitro and in vivo. Furthermore, ST6GAL2 promoted tumorigenesis by inactivating the Hippo signaling pathway. Resveratrol is a native compound extracted from Vitis species, and many studies have confirmed its protective cardiovascular and antineoplastic effects. Here we found that resveratrol can inhibit the tumorigenesis of FTC by suppressing the expression of ST6GAL2, further activating the Hippo pathway. In summary, this study revealed the role of the ST6GAL2-Hippo signaling pathway in FTC tumorigenesis and indicated that resveratrol, a commonly found antineoplastic compound, could inhibit tumorigenesis of FTC by regulating the abovementioned pathways. Keywords: follicular thyroid carcinoma, resveratrol, Hippo signaling pathway, sialyltransferase families

In an attempt to solve the problems of the low intelligent distribution degree and high working intensity of auxiliary transportation systems in underground coal mines, an intelligent distribution strategy of materials in the whole mine is put forward. Firstly, combined with the characteristics of materials and standard containers, a three-dimensional loading model is established with the goal of maximizing the space utilization of standard containers, and a three-dimensional space segmentation heuristic algorithm is used to solve the material loading scheme. Then, the multi-objective optimization model of distribution parameters is established with the goal of the shortest delivery distance, the shortest delay time, and the fewest number of delivery vehicles, and the dual-layer genetic algorithm is used to solve the distribution scheme. Finally, the spatiotemporal conversion coefficient is designed to solve the task list by hierarchical clustering, and the solution time is reduced by 30%. The results show that the dual-layer genetic algorithm based on hierarchical clustering has good adaptability in complex material scheduling scenarios.