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Possibility of synthesis gas (syngas) production from waste lubricant oil (WLO) through gasification process has been investigated. The objective of this work is to develop a comprehensive model to...

Primary cutaneous CD30+ T cell lymphoproliferative disorders (PCLPD), the second most common type of primary cutaneous T cell lymphomas, accounts for approximately 25-30% of cutaneous T-cell lymphoma cases. However, only small retrospective studies have been reported. We aimed to identify prognostic factors and evaluate the overall survival (OS) of patients with PCLPD stratified by ethnicity. We identified 1496 patients diagnosed with PCLPD between 2004 and 2014 in the US National Cancer Database. Chi-square test and anova were used to evaluate differences in demographic and disease characteristics, socioeconomic factors and treatments received. OS was evaluated with the log-rank test, Cox proportional hazard regression analysis, and propensity score matching. The study included 1267 Caucasians, 153 African Americans (AA), 43 Asians, and 33 of other/unknown ethnicity. Older age, higher Charlson-Deyo score, higher clinical stage and receipt of chemotherapy were predictors of shorter OS. Primary disease site on a lower extremity was associated with shorter OS, while a head and neck location was associated with longer OS. AA patients had shorter OS when compared to Caucasian patients on multivariate analysis. This ethnic disparity persisted on propensity-score matched analysis and after matching Caucasian and AA patients on demographic and disease characteristics, socioeconomic factors and treatments received, and age and gender-matched relative survival analyses.

Pemphigus vulgaris is an autoimmune blistering disease characterized by a loss of epidermal cell–cell adhesion caused by anti-desmoglein (Dsg) autoantibodies. The pathogenesis of PV remains unclear. However, abnormal frequency and function of Th2 cells are believed to contribute to PV. We investigated Nr4a2, a transcription factor, which has been found to regulate T cell differentiation, for its association with Th2 cell differentiation and functions in PV. We found significantly decreased mRNA and protein levels of Nr4a2 in CD4+ T cells from patients with PV, compared with healthy control subjects. In addition, mRNA and protein levels of Nr4a2 in CD4+ T cells were inversely correlated with serum levels of IL-4 and IL-13 in patients with PV. Overexpression of Nr4a2 in CD4+ T cells from patients with PV significantly reduced the mRNA levels of GATA3, IL-4, and IL-13, while Nr4a2 siRNA treatment showed the reverse effects on the expression of these Th2-related cytokines and transcription factors. The data suggest that the altered level of Nr4a2 in CD4+ T cells is associated with the development of PV. Nr4a2 may contribute to the pathogenesis of PV by negatively regulating Th2 activity and secretion of Th2-related cytokines.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the development of multiple jaw keratocysts and basal cell carcinomas (BCC) and accompanied by diverse phenotypes. The establishment of diagnosis lies on the identification of a heterozygous germline pathogenic variant in the patched homolog 1 gene (PTCH1). PTCH1 has alternative splicing and selective initial coding exon, leading to three types of encoding proteins (PTCHL, PTCHM and PTCHS). The expression of each protein in NBCCS remains ambiguous, especially the importance of the first two exons in translation. Here, we report a Chinese NBCCS family of a novel PTCH1 heterozygous mutation (IVS 2, c.394+1G>T, g.10652G>T) identified by genomic sequencing and reverse-transcription-PCR as aberrant splicing. To the best of our knowledge, this is the first report of NBCCS with a splicing site mutation in intron 2 resulting in exon 2 skipping. Our finding suggests that exon 2 plays an important role in the development of NBCCS and further speculates that the role of longer isoforms PTCHL and PTCHM is crucial in NBCCS, while that of short isoform PTCHS might be dispensable.

Privileged structures are conductive to discover novel bioactive substances because they can bind to multiple targets with high affinity. Quinones are considered to be a privileged structure and useful template for the design of new compounds with potential pharmacological activity. This article presents the recent developments (2014-2021 update) of quinones in the fields of antitumor, antibacterial, antifungal, antiviral, anti-Alzheimer's disease (AD) and antimalarial, mainly focusing on biological activities, structural modification and mechanism of action.

Background/Aims: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. Methods: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data. Results: There were 66 patients diagnosed with small intestine angiosarcoma. The onset age ranged from 24–92 years old. There were 24 patients diagnosed before the year 2000, and 42 patients were diagnosed after 2000. The data indicated that 49 cases were diagnosed as primary disease, and the remaining 15 cases were secondary disease. The main clinical symptoms were nonspecific and included gastrointestinal (GI) bleeding and abdominal pain. Additionally, we found multi-center foci were one of the characteristics of this disease. Radiation-induced small intestine angiosarcoma (RSIA) is a special type of disease with a similar prognosis. This type was more frequent in females and decreased after the year 2000. We also found that GI bleeding was less common in RSIA cases. The log-rank test results revealed that old-age, poor differentiation, and GI bleeding were associated with worse prognosis. Surgical treatment showed a trend toward a prolonged survival time. However, the result was not statistically significant. Our results show treatment with adjuvant therapy improved prognosis. The multivariate Cox analysis demonstrated adjuvant therapy was an independent indicator of a favorable outcome in small intestine angiosarcoma patients. Conclusion: Pay attention to the unexplained gastrointestinal bleeding could lead to a faster diagnosis and control of small intestine angiosarcoma. Furthermore, treatments including adjuvant therapy can effectively improve the prognosis.

It remains controversial whether concurrent or subsequent chemoradiotherapy (CRT) provides additional survival benefits when compared to radiotherapy (RT) alone in localized extranodal natural killer/T-cell lymphoma (ENKTL), nasal type We identified 248 patients from the US National Cancer Data Base who were diagnosed with localized ENKTL from 2004-2014; 68.9% received CRT and 31.1% received RT alone. Over time, the use of CRT increased, while the use of RT alone decreased (p .001). On multivariate analysis, CRT was associated with longer OS than RT alone (HR: 0.504; 95% CI: 0.338-0.751; p .001), while uninsured status and African-American race were associated with shorter OS. The survival advantages of CRT over RT alone persisted on propensity score matching for the entire cohort (p = .0014) and in a subgroup analysis of elderly patients (p .001). In conclusion, patients who received CRT had significantly longer OS than those who received RT alone. These results also apply to elderly patients.

Fas, which is an apoptotic-related protein, has an important role in cell apoptosis. Fas ligand (FasL) binds to Fas and activates apoptosis signal transduction. We previously demonstrated that the efficiency of celecoxib inhibited the proliferation and apoptosis of HT-29 colon cancer cell line. The BGC823 cell line was used as an experimental model to evaluate the potential role of celecoxib on gastric cancer cell apoptosis. Inhibitory effects of celecoxib on cell viability were determined by MTT assay. Cell apoptosis was evaluated by flow cytometric analysis and laser confocal microscopy. The results of the present study demonstrated that celecoxib inhibited the viability of BGC823 cells in a concentration- and time-dependent manner. Furthermore, the effect of BGC823 cells apoptosis was increased in a concentration-dependent manner. Western blotting was used to determine the protein expression levels of Fas, FasL, and B-cell lymphoma-2 (Bcl-2). During the celecoxib-induced apoptosis of BGC823 cells, celecoxib upregulated Fas expression and downregulated FasL and Bcl-2 expression in a concentration-dependent manner. These results suggest that celecoxib inhibited the growth and induced apoptosis of BGC823 gastric cancer cells by regulating the protein expression of Fas, FasL and Bcl-2.

Proper representation plays a significant role in pattern recognition fields, effective representation of an image makes it easier to be distinguished from images of other classes and can improve the accuracy of classification. In this paper, to obtain appropriate representation of a face, we propose a novel method to represent an original sample. We crop the original image into a number of non-overlapping blocks, and certain operations are applied to each block, then merge all the modified blocks and obtain a new representation of the original sample. Furthermore, we integrate original samples and its corresponding block representations, which provide more local information of images and allow higher accuracy to be achieved. The extensive experiments demonstrate that our proposed method is robust and obtain better accuracy for face recognition in comparison with previous methods.

A dual-parallel-evaporator heat pump system, which has two parallel evaporators for cabinet air-conditioning and battery temperature control respectively, is designed to realize thermal management for electric vehicles. System performance and refrigerant mass flow distribution character of two branches at different opening degrees of electric expansive valve are tested. Changes of refrigerant superheat degree and pressure at the outlet of battery side evaporator caused by the decreasing of the battery temperature have great effect on mass flow rate of cabinet branch. The maximum mass flow rate reduced ratios of cabinet branch is 20.5% when the opening degree of electric expansive valve (EEV) of battery branch is 0.3. Stable performance of this system on rated condition is tested by adjusting the opening degree of two EEVs to get the optimal status. The experimental results indicate that integration operation can supply additional 1.04 kW cooling capacity for battery unit with very little compressor power increase. However, cooling capacity of cabinet side only decreases by 0.95%. The additional parallel evaporator is desirable to solve the battery cooling problem.

Utilizing cabin return air to heat the cabin can reduce the heating load and save the battery power of Electric vehicle, but it is difficult to avoid fogging on the windshield caused by the high humidity of the return air. In this paper, the climate characteristics of the vehicle interior is analyzed by simulation with a thermal model based on the whole cabin. The simulation model is verified by an experimental test on a real car, and the errors are within 7%. The fogging conditions at different driving speeds and external air environments are drawn from the simulation results. An increase in external temperatures or a decrease in external humidity can benefit for increasing the return air ratio. The return air ratio decreases with the higher driving speed due to increases in the convective heat transfer coefficient, which leads to a lower temperature of the glass surface. This influence of the driving speed depends on the relative humidity of external air and becomes more obvious at the higher relative humidity conditions.

The performance and robustness of face recognition are largely determined by the data samples used for model training. To obtain more representative samples of a face, this paper proposes a novel approach to acquire two groups of virtual samples from the right singular vectors as well as from left singular vectors via singular value decomposition (SVD) for each class of training samples. The generated virtual images not only enrich training samples but also obtain more representative information of faces, therefore higher accuracy of face recognition is achieved. Furthermore, we propose a simple and effective method that automatically determines adaptive weight without any manual intervention for three groups of scores, including the original samples and two groups of virtual samples. The weighted score fusion scheme is able to offer more supplementary information from multiple sources and obtain better performance in face recognition. Experiments on three benchmark datasets demonstrate that our proposed method is robust and obtains better accuracy for face recognition compared with previous methods.

Utilizing the return air and fresh air properly is a promising approach to meet the demand for anti-foggy and energy-saving at the same time in electric vehicle (EV). In this paper, a concept of applying a continuous anti-fogging air curtain for front windshield glass to realize the maximum-return-air utilization in winter is presented. Accordingly, heating demand model of EV is built up by taking account of the return air ratio (RAR). The research results indicate that the heating demand can be reduced by 46.4–62.1% compared to the all-fresh-air condition when the ambient temperature is −5 °C to −20 °C. And, air source heat pump (ASHP) system performance under different RARs is tested experimentally in −20 °C ambient temperature to predict the energy-saving potentials. The coefficient of performance (COP) of ASHP decreases with the increasing of RARs. Heating capacity of ASHP presents little difference at different RARs. Equivalent COP (ECOP) is used to evaluate the EV heating, ventilation and air conditioning (HVAC) system comprehensive performance. The highest ECOP is 1.57 when the RAR is 0.46, which is 12.1% higher than that of all-fresh-air condition. Accordingly, the maximum energy saving is 40.6%. Moreover, COP change rate of ASHP with compressor speed is used to get optimal compressor speed.

The traditional Air Source Heat Pump (ASHP) for Electric Vehicles (EVs) has many limits in cold region because of poor heating performance and operating safety in low ambient temperature, which can be solved by the ASHP with refrigerant injection. A test bench that can be switched between a traditional ASHP system and a refrigerant injection ASHP system for EVs in the cold region is developed in this study. Compressors applied in the test bench are refitted with different injection portholes from the regular electric scroll compressor to analyze the influence of porthole shape on the system performance. The experimental results show that the heating capacity of refrigerant injection ASHP system is raised up by 28.6% compared with the traditional system. The larger injection porthole helps to increase the heating capacity when in-car inlet air temperature is higher, and the effect of injection porthole shapes to injection process and refrigerant cycle is also analyzed. The research will contribute to the application of refrigerant injection technology in EVs.

In order to demonstrate the possibilities of application of MESSAGE tool for the modelling of a Nuclear Energy System at the national level, one of the possible open nuclear fuel cycle options based on thermal reactors has been modelled using MESSAGE. The steps of the front-end and back-end of nuclear fuel cycle and nuclear reactor operation are described. The optimal structure for Nuclear Power Development and optimal schedule for introducing various reactor technologies and fuel cycle options; infrastructure facilities, nuclear material flows and waste, investments and other costs are demonstrated.

State-of-the-art sparse representation methods are always constructed on the basis of the similarity metric. In this paper, we propose a new metric that is dissimilarity metric based on collaborative representation (CR) method, which represents the relation between a test sample and a class from a new viewpoint and provides the information different from that offered by the distance metric in conventional sparse representation (SR) methods. The basic idea is that: we determine the dissimilarity between a test sample and the i -th class by exploiting the contribution to representing the test sample of the other classes. If the contribution is greater, the dissimilarity between them is also considered as greater. Simultaneously, integrating the dissimilarity metric and conventional similarity metric, this can lead to richer information so that it is able to get higher accuracy. Experiments on the most widely used and challenging benchmark datasets demonstrate that our method can obtain better accuracy and robustness in comparison with some previous methods. Meanwhile, the designed method is not only mathematically tractable but also performs very well in biometrics.

This paper aims to achieve high-accuracy 3D object detection, in which we propose a novel Spatial-Channel Attention Network (SCANet), a two-stage detector that takes both LIDAR point clouds and RGB images as input to generate 3D object estimates. The first stage is a 3D region proposal network (RPN) in which we put forward a new Spatial-Channel Attention (SCA) module and an Extension Spatial Upsample (ESU) module. Using the pyramid pooling structure and global average pooling, the SCA module can not only effectively incorporate multi-scale and global context information, but also produce spatial and channel-wise attention to select discriminative features. The ESU module in the decoder can recover the lost spatial information caused by consecutive pooling operators to generate reliable 3D region proposals. In the second stage, we design a new multi-level fusion scheme for accurate classification and 3D bounding box regression. Experimental results demonstrate that SCANet achieves state-of-the-art performance on the challenging KITTI 3D object detection benchmark.

In this paper, a coarse-to-fine framework for image noise removal is proposed. The bilateral filter is redefined by the manner of progressive refining to effectively eliminate noise, thus forming progressive refinement bilateral filter (PRBF), which estimates the pixel values of a noisy image through the method of progressive refinement with gradual recursion and its result retains more details, infinite close to the original image. PRBF is further integrated into the denoising model for the details processing again after denoising of the major part of the image. Our algorithm is evaluated and compared on two large standardized datasets and a number of selected images. The experimental results show that our algorithm consistently outperforms other approaches for image denoising and demonstrates the effectiveness of our framework for stereo matching.

Dermatomyofibroma is a benign and rare proliferation of myofibroblasts and fibroblasts of the skin. Dermatomyofibroma commonly locates at the shoulder and neck of young adults and adolescents. Other frequently affected anatomic sites are upper arms, thigh, chest wall, back, axillary region and abdomen. Herein, we reported a case of dermatomyofibroma occurred in the nasion. The asymptomatic firm nodule and histopathological features were consistent with dermatomyofibroma. Immunohistochemically, the tumor cells expressed vimentin, HHF35 and α-smooth muscle actin (α-SMA). The patient was followed up for 2 years after excision of the tumors and recurrences were not observed.皮肤肌纤维瘤是一种少见的良性皮肤软组织肿瘤，病变为成纤维细胞和肌成纤维细胞增殖，常见于年轻成年人和青少年的肩部及颈部，其次好发于上臂、大腿、胸壁、背部、腋窝和腹部。本文报道1例罕见发生于鼻部的皮肤肌纤维瘤，此例肿物表现为无症状的坚硬的皮肤结节，病理上证实与皮肤肌纤维瘤相符。免疫组织化学结果显示，肿瘤细胞表达波形蛋白(vimentin)、肌特异性肌动蛋白(HHF35)和平滑肌肌动蛋白(α-smooth muscle actin，α-SMA)。手术切除后随访2年无复发。.

Electro-osmosis regeneration (EOR) of solid desiccant is a promising alternative method for dehumidification. Macroporous silica gel (MSG) has good performance on both moisture adsorption capacity and EO effect. In this paper an experimental bench is set up to investigate the water migration character and mechanism between the air and MSG in the coupling process of moisture adsorption and EOR. Through several continuous and oft-repeated experiments under different voltages, the experimental results validate that water can be transferred to a higher relative humidity environment through MSG by EO effect. It is found that the saturated water content around the anode decreases about 1.71% and 2.76% after twice EOR processes respectively. This phenomenon means the moisture re-adsorption capacity of MSG around the anode gets weaker after EOR. Based on the experimental results, the water migration mechanism of the coupling process is analyzed. Moreover, EO effect of MSG is studied from a new perspective. The water mass induced by EO has a near linear relationship with the electric charge transport with a certain EO starting value. The coefficient between the migration water mass and quantity of electric charge is about 0.0536 g/C under the experimental condition.

Patients with lupus erythematosus (LE) specific cutaneous manifestations distributed along the lines of Blaschko are seldom encountered in clinic. In this paper, we reported 5 new cases and perform a systematic review of all the published cases in the English and Chinese literature. We provide a comprehensive summary of the clinical manifestations and explore potential etiology and pathogenesis. Sixty-eight published papers (53 English and 15 Chinese) and 93 cases (including 5 cases reported by us) were included in the analysis. In contrast to classical cutaneous LE, these cases have a series of distinctive clinical features and also have a potentially unique pathogenesis. The pathogenesis of this condition may involve the presence of mosaic abnormal skin cells, possessing crucial pathogenic gene(s)/epigenetic modification(s), located along the lines of Blaschko during embryogenesis. A comparison of the mosaic cells and surrounding "wild-type" cells and in-depth exploration of the interaction between susceptive gene(s)/epigenetic modification(s) and the immune system may potentially bring to light the secrets hidden in LE. Thus, we consider this condition to be a distinct subtype of LE and "Blaschko-linear lupus erythematosus" would be a more appropriate designation. The clues provided in the study of the pathogenesis of this form of LE may potentially unlock the mysteries of the various forms of LE as a whole.

In order to do source apportionment of PM2.5 and source trajectories, particle induced X-ray emission and energy disperse-X ray fluorescence were used to analyze chemical composition of samples. Five major sources have been identified by using positive matrix factorization. Source trajectories have been determined by conditional probability function and the potential source contribution function. Extreme events, such as sandstorms, have been identified and traced.

Indeterminate cell histiocytosis (ICH) is a very rare histiocytic disease. We reported a case of generalized ICH presenting as eroded papules and crusts, accompanied with intermittent fever, pulmonary disorder, lymphadenectasis in the mediastinum, and the retroperitoneum. The histopathology indicated a neoplasm that was composed of small nests of large cells with ample pale cytoplasm. Immunohistochemistry results and the absence of Birbeck granules led us to the diagnosis of ICH. Four months later, the patient died of anemia, ascites, and swelling of the limbs.

The correlation between systemic lupus erythematosus (SLE) and microbiota colonization has been receiving much attention during recent years. Here, we screened the cutaneous bacterial spectrums of 69 SLE patients, 49 healthy controls and 20 dermatomyositis (DM) patients and identified the specific changes of cutaneous microbial composition and abundance in SLE patients. We observed the decreasing diversity in community richness and evenness and the greater heterogeneity in SLE patients compared to healthy controls, which were also different from the cutaneous microbiome of DM patients. The skin microbial community disorders in SLE patients were correlated with several clinical features such as serum low complement level, gender, renal involvement and myositis. According to the Kruskal-Wallis (KW) test, receiver operating characteristic (ROC) curve and LDA Effect Size (LEfSe) analysis, several bacterial taxa such as Staphylococcus, especially Staphylococcus aureus and Staphylococcus epidermidis, were identified to be potential markers for SLE skin lesions. Furthermore, Picrust analysis showed that Staphylococcus aureus infection pathway was significantly enriched and exhibited a strong correlation with genus Staphylococcus in SLE patients. The changes in the composition and abundance of cutaneous microbiota in SLE patients suggest that the microbial dysbiosis is associated with the pathogenesis of SLE, which may be potentially reliable biomarker or therapeutic target for SLE.

Background The efficacy of Helicobacter pylori (H. pylori) eradication has steadily declined, primarily because of antibiotic resistance. This study aimed to evaluate the efficacy and safety of furazolidone eradication therapies as initial treatments for H. pylori infection. Methods A national, multicenter, open-label, randomized controlled trial was performed at 16 sites across 13 provinces in China to evaluate the efficacy and safety of furazolidone-containing therapies for H. pylori infection. Treatment naive patients were randomly assigned to: esomeprazole 20 mg, bismuth 220 mg, amoxicillin 1000 mg, and furazolidone 100 mg twice daily for 10 and 7 days (FAB 10 and FAB 7; the same therapy without bismuth (FA 10 and FA 7). The primary and secondary outcomes were the eradication rate and regimen safety, respectively. Treatment success was assessed by the 13 C urea breath test at least 4 weeks after treatment completion. Results Overall, according to intention-to-treat (ITT) analysis, the eradication rates for FAB 10 and FAB 7 were 86.6% (95% confidence interval [CI], 79.9%-93.2%) and 83.6% (95% CI, 76.3%-90.9%) and for FA 10 and FA 7 were 82.4% (95% CI, 74.9%-89.8%) and 77.6% (95% CI, 69.4%-85.8%), respectively. According to per-protocol analysis, the overall eradication rates for FAB 10 and FAB 7 were 94.7% (95% CI, 90.3%-99.1%) and 90.8% (95% CI, 85.1%-96.5%) and for FA 10 and FA 7 were 90.6% (95% CI, 84.9%-96.3%) and 85.1% (95% CI, 78.2%-92.1%), respectively. The overall prevalence of side effects was 8.1%. Conclusions Furazolidone-containing therapies, particularly the tested 10-day quadruple therapy, exhibited satisfactory efficacy and safety. This 10-day quadruple therapy represents a promising initial treatment strategy for Chinese patients.

Psoriasis is a chronic, immune-mediated inflammatory skin disease. As psoriasis rarely occurs in nonhuman animals, the lack of an ideal animal model reflecting the histopathological and molecular immunological characteristics of psoriasis remains an urgent issue. In the present study, an imiquimod-induced psoriasis-like dermatitis mouse model was constructed under natural immune conditions and verified by evaluations of the Psoriasis Area and Severity Index (PASI) score and Baker score, H&E staining, immunohistochemical examination of the CD3 and Gr1 levels, measurement of plasmacytoid dendritic cell- (pDC) and Th17-associated cytokine levels, and evaluation of p65 phosphorylation and TLR7 expression. Moreover, rutaecarpine (RUT), the main active ingredient in the traditional Chinese medicine Wu-Zhu-Yu, could improve psoriasis-like dermatitis through effects on pDC- and Th17-associated cytokines through NF-κB and toll-like receptor 7 (TLR7) signaling. Taken together, the imiquimod-induced psoriasis-like dermatitis mouse model can be regarded as an ideal model for evaluating psoriasis pathogenesis and antipsoriatic drugs. We provided theoretical and experimental evidence for the clinical application of RUT in psoriasis.

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a very rare form of peripheral α/β T cell skin lymphoma that is localized primarily in the subcutaneous adipose tissues. It is characterized by single or multiple painful subcutaneous nodules or lumps, often affecting the limbs. The patient presented to the Department of Dermatology, Second Xiangya Hospital, Central South University, who suffered from intermittent fever and erythema on the body, finally was diagnosed as SPTCL after histopathological examinations for twice.皮下脂膜炎性T细胞淋巴瘤是一种少见的主要累及皮下脂肪组织的外周α/β 型T细胞淋巴瘤，临床表现为无痛性皮下结节或肿块，可单发或多发，常累及四肢。本例患者以发热和躯干部红斑为首发症状，经过2次组织病理检查最终确诊为皮下脂膜炎性T细胞淋巴瘤。.

Systemic anaplastic lymphoma kinase positive (ALK+) anaplastic large cell lymphoma with extranodal involvement (ALCL-E) is a rare form of non-Hodgkin lymphoma. No large study in the literature has compared the survival outcomes among different primary extranodal sites of involvement in ALK+ ALCL-E. We identified 1306 patients with ALK+ ALCL-E diagnosed between 2004 and 2014 in the US National Cancer Database, among whom 387 had primary extranodal site in the chest/abdomen/pelvis, 103 in the bone, 62 in the central nervous system, 134 in the head and neck and 620 in the cutaneous/soft tissue. Younger age, lower Charlson-Deyo score, lower clinical stage, receipt of chemotherapy and receipt of radiotherapy were predictors of longer overall survival. Patients with extranodal involvement of central nervous system and chest/abdomen/pelvis had shorter overall survival than those with involvement of head and neck, bone, and cutaneous/subcutaneous tissue after adjusting for confounding variables. We recommend treating these patients upfront with more aggressive therapy.

From the old Chinese saying “While his parents are alive, the son may not go abroad to a distance.” to the new buzzwords “There is such a lot of world to see.”. Different attitudes towards tourism bear the marks of times and technology. Since the 21st century, with the continuous improvement of China's economic and per capita disposable income, the tourism industry has undergone enormous changes in the wave of Internet tourism. On september 16, 2015, China National Tourism Administration issued Notification on the Implementation Plan of “Travel + Internet” Action. This notification points out that in the new round of science and technology revolution, the combination of Internet and tourism has brought a subversive change to the traditional tourism industry, and the deep integration of the two has become an irreversible trend of the times. To grasp the new vision of tourism integrated into Internet, we should sort out two key factors [1] of tourism and Internet. One is the force of the core factors of Internet and the other is the key components of tourism system. Thus can ultimately stimulate The strategic global evolution of the tourism industry.

Since the performance of conventional air source heat pump (ASHP) for electric vehicles (EVs) is apt to decline sharply in low ambient temperature, it will consume more electricity of the cell, and affect driving mileage in cold regions. Aiming at developing high efficiency heating system for EVs in cold regions, an ASHP system applying refrigerant injection for EVs is designed, as well as the test bench is built to investigate its performance. According to the operation condition of EVs, heating performances are tested on different in-car inlet air temperature and various fresh air ratios under −20 °C ambient temperature. The system cycle process with refrigerant injection, as well as the influences of refrigerant injection and dryness are also analyzed and discussed. The results show that the heating capacity of the ASHP with refrigerant injection can be increased up to 31%, and in comparison with the conventional heat pump system its heating performance is better when in-car inlet temperature is above −10 °C. Therefore, ASHP with refrigerant injection has great potentiality to be applied for the EVs in cold regions.

Eosinophilic skin diseases, commonly termed as eosinophilic dermatoses, refer to a broad spectrum of skin diseases characterized by eosinophil infiltration and/or degranulation in skin lesions, with or without blood eosinophilia. The majority of eosinophilic dermatoses lie in the allergy-related group, including allergic drug eruption, urticaria, allergic contact dermatitis, atopic dermatitis, and eczema. Parasitic infestations, arthropod bites, and autoimmune blistering skin diseases such as bullous pemphigoid, are also common. Besides these, there are several rare types of eosinophilic dermatoses with unknown origin, in which eosinophil infiltration is a central component and affects specific tissue layers or adnexal structures of the skin, such as the dermis, subcutaneous fat, fascia, follicles, and cutaneous vessels. Some typical examples are eosinophilic cellulitis, granuloma faciale, eosinophilic pustular folliculitis, recurrent cutaneous eosinophilic vasculitis, and eosinophilic fasciitis. Although tissue eosinophilia is a common feature shared by these disorders, their clinical and pathological properties differ dramatically. Among these rare entities, eosinophilic pustular folliculitis may be associated with human immunodeficiency virus (HIV) infection or malignancies, and some other diseases, like eosinophilic fasciitis and eosinophilic cellulitis, may be associated with an underlying hematological disorder, while others are considered idiopathic. However, for most of these rare eosinophilic dermatoses, the causes and the pathogenic mechanisms remain largely unknown, and systemic, high-quality clinical investigations are needed for advances in better strategies for clinical diagnosis and treatment. Here, we present a comprehensive review on the etiology, pathogenesis, clinical features, and management of these rare entities, with an emphasis on recent advances and current consensus.

In this study, sustained-release of GnRH antagonist peptide LXT-101 was realized through oil formulation, and their releasing characteristics in vitro and in vivo were investigated. In this formulation, the static interaction between cationic charged peptide LXT-101 and the negative charged phospholipid led to the formation of the phospholipid-peptide complex, by which LXT-101 was completely dissolved in oils. This formulation was prepared by mixing an aqueous solution of LXT-101 and empty SUV (small unilamellar liposomes) containing EPC (phosphatidylcholine) and DPPG (1, 2-dipalmitog-sn-glycero-3- phosphoglycerol) at an appropriate ratio, the mixture was subsequently lyophilized, and the resultant was dissolved in the oil to form a clear oily solution containing solubilized peptide LXT-101. With atomic force microscopy combined with Langmuir-Blodgett technology, the morphology of the particles in the oily solution were examined to be oval-shaped and the mean particle size was 150 nm in diameter. In pure water at 37°C, about 70~90 % of LXT-101 was released slowly from the oily formulation over 7 days. An effective sustained suppression of testosterone in beagle dogs could be achieved over a period of seven days with this LXT-101 oily formulation, by i.m. at a dose of 0.2 mg/kg (2 mg/ml). This formulation dramatically improved the bioactivity of LXT-101 compared to its aqueous solution. It was also found that when the concentration of peptide LXT-101 was up to or over 10 mg/ml in aqueous solution, there was no significant difference between the oily formulation and aqueous solution. This fact meant that LXT-101 itself could conduct sustained release in vivo by self-assembly of nanofibers.

In this paper, the possibility on electro-osmosis regeneration of macro-porous silica gel (MSG) desiccant has been investigated by testing the adsorption and electro-osmosis characteristic. The measured saturated moisture content of MSG is 113% in 300 K temperature and 95% relative humidity. Its zeta potential is −10.92 mV, which shows it has both good moisture absorption and electro-osmosis characteristic. The experiment bench is built to test the electro-osmosis regeneration performance on MSG by means of changing initial moisture content (105% and 110%) and applied voltage (40 V, 50 V and 60 V) respectively. The D -value of moisture content between the bottom and upper half with voltage is much higher than that without voltage. For the 110% initial moisture content, there are many visible condensing water droplets on the inside surface of plastic film under the cathode. Based on experimental results, it can find electro-osmosis flow exists when the moisture content is lower than the saturated moisture content. Besides, the electro-osmosis regeneration is one potential method of MSG desiccant when it is applied in dehumidification.

The facility for delayed neutron counting was built at the China Institute of Atomic Energy in the 1980s. A method of normalized decaying curve of delayed neutron is proposed in this work. Preliminary experiments show that this method is suitable for the determinations of uranium in samples with a wide range of uranium concentrations.

The performance and robustness of fatigue detection largely decrease if the driver with glasses. To address this issue, this paper proposes a practical driver fatigue detection method based on face alignment at 3000 FPS algorithm. Firstly, the eye regions of the driver are localized by exploiting 6 landmarks surrounding each eye. Secondly, the HOG features of the extracted eye regions are calculated and put into SVM classifier to recognize the eye state. Finally, the value of PERCLOS is calculated to determine whether the driver is drowsy or not. An alarm will be generated if the eye is closed for a specified period of time. The accuracy and real-time on testing videos with different drivers demonstrate that the proposed algorithm is robust and obtain better accuracy for driver fatigue detection compared with some previous method.

Background Studies have shown contradictory results regarding the survival outcomes among white, African American, and Asian patients with mycosis fungoides (MF). Objective To evaluate the survival outcomes among white, African American, and Asian patients with MF and to determine other prognostic factors of the disease. Methods The US National Cancer Database was used to identify patients with histologically confirmed MF from 2004 to 2014. Clinicopathologic, socioeconomic, and treatment data were compared among the races by using the chi-square test. Overall survival was evaluated by using the log-rank test, multivariable Cox proportional hazard regression, and propensity score–matched analysis. Results Of 4459 patients with MF, 77.7% were white, 19.2% were African American, and 3.2% were Asian. Older age, treatment received in a community facility, government insurance, higher Charlson-Deyo score, male sex, higher clinical stage, receipt of radiotherapy or chemotherapy, and African American race were predictors of poor overall survival on multivariate analysis ( P P = .07). Limitations Retrospective analysis. Conclusion African American patients with MF demonstrated poorer survival than white patients after accounting for disease characteristics, socioeconomic factors, and types of treatment, warranting further investigation into the underlying biology of MF and prescribed treatment modalities.

Additional file 1. Additional figures and tables.

Sparse representation, which represents the test sample as a linear combination of the whole training samples, achieved great success in face recognition. It can obtain a good performance if there exist enough training samples. However, the number of face images of a subject is usually limited in real face recognition systems. In this paper, in order to obtain more representations of a face, we propose a novel method that applies the singular value decomposition (SVD) to produce virtual images of original images. Furthermore, we integrate the virtual samples and its original samples, which allows more information of the same class object to be available, so better performance can be achieved. Experiments on the most widely used and challenging benchmark datasets demonstrate that our method can obtain better accuracy and robustness in comparison with previous methods.

Psoriasis is a common and chronic autoimmune skin disease which affects 2 to 3% of the world population. Abnormal proliferation of human keratinocytes is an important feature of psoriasis, along with local hypoxia and vascular abnormal growth. To leverage recent molecular findings into the personalized treatment of psoriasis, we need a strategy that integrates clinical stratification with molecular phenotyping. MicroRNAs (miRNAs) are a large family of small non-coding RNA which regulates diverse biological process, including cell proliferation, by modulating gene expression at the posttranscriptional level. In the present study, we indicated that miR-150 specifically down-regulated expressed in psoriatic skin lesions, and could inhibit HaCaT cells and primary adult human keratinocytes (HKCs)' proliferation in either normal or hypoxia conditions; by direct targeting, miR-150 could also regulate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor A (VEGFA). In addition, we found that HIF-1α and VEGFA were highly expressed in the lesional psoriatic skin compared with the non-lesional psoriatic skin, and negatively correlated with miR-150 expression. Taken together, we indicated miR-150 regulates human keratinocytes' proliferation in hypoxic conditions through targeting HIF-1α and VEGFA in psoriasis for the first time, and provide diagnostic markers and a novel target for psoriasis treatment.

Optically pumped atomic magnetometers based on spin exchange relaxation free regime have recently become a powerful tool in the field of magnetoencephalography measurements. For this application of magnetometers, simultaneous multilocation magnetic field measurements are desired. To fulfill the requirement, we develop a multi-channel sensor module based on a single large vapor cell. The probe beam passes through the vapor cell twice by reflection and then records the two-dimensional spatial magnetic field distribution with two 2 × 2 photodiode matrixes. Comparing with the previous multi-channel tangential magnetic field measuring sensors, our magnetometer is sensitive to the normal magnetic field by operating in the longitudinal parametric modulation mode. Measuring the normal component is considered more suitable for magnetoencephalography, because the normal component provides more information. The sensitivities of the channels are approximately 10 fT/Hz1/2 in the normal direction. The auditory evoked magnetic fields of the four adjacent locations perpendicular to the scalp are detected simultaneously. Our magnetometer can measure the normal and tangential magnetic fields simultaneously. The dual-axis vector measurement of magnetic field is very important for magnetoencephalography.