763 results on '"Grimes, H. Leighton"'
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102. Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment
103. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells
104. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival
105. Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms
106. Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors
107. V2 Trial: A Phase I Study of Venetoclax Combined with CPX-351 for Children, Adolescents and Young Adults with Relapsed or Refractory Acute Leukemia
108. DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data
109. cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes
110. Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
111. Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML
112. Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation
113. The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification
114. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
115. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential.
116. Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+T cell identity and function
117. SKI Controls MDS-Associated Chronic TGFb Signaling, Aberrant Splicing, and Stem Cell Fitness
118. The Erythro-Myeloblastic Island (EMBI): A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis
119. Neutropenia-Associated Mutations Differentially Impact Developmental Cell-States
120. A Prognostic Human Splicing Signature That Precurses Leukemia
121. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
122. cellHarmony: Cell-level matching and holistic comparison of single-cell transcriptomes
123. Severe Congenital Neutropenia-Associated Mutations Reveal Stage-Specific GFI1-Dependent Checkpoints in Myeloid Development
124. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
125. Understanding Early Stage Myelodysplastic Syndrome Pathobiology
126. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential
127. DoubletDecon: Cell-State Aware Removal of Single-Cell RNA-Seq Doublets
128. Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors
129. KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia
130. Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation
131. A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap
132. Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression
133. Mitochondrial Morphology Controls Hematopoietic Stem Cell Self-Renewal and Confers Them Divisional Memory
134. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
135. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation
136. Independent production of distinct monocyte subsets by granulocyte-monocyte progenitors (GMPS) and monocyte-dendritic cell progenitors (MDPS)
137. Severe congenital neutropenia-associated mutations induce aberrant stage-specific genetic programs that underlie broad myeloid defects
138. Counting the cost of lineage decisions
139. The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis
140. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia
141. Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire
142. Enhanced MAPK Signaling Constitute Non-Oncogene Addiction in CSF3R Induced Leukemia
143. Regulation of Hematopoietic Stem and Progenitor Cell Differentiation By Mirn23a/b Micrornas
144. A Common Signaling Node Constitute Non-Oncogene Addiction in Kinase Driven Leukemia:Mechanism of Oncogne Addiction in CML
145. Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions
146. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
147. KLF5 deficiency is required for B-cell lymphoid progenitor leukemogenesis to promote glutathione biosynthesis and prevent oxidative stress
148. Temporal expression of Bim limits the development and repertoire of TCR+ double negative thymocytes and CD8αα intestinal intraepithelial lymphocytes.
149. Systemic Inflammation Recruits Ccr7+ Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner
150. HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development
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