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Any clue with the symbol // in the middle is a before-and-after. For example, 'False//Football,' four letters, would yield 'Flag' (False Flag' and 'Flag [...]

I SPENT THE SUMMER OF 1985 in Dusseldorf, West Germany. By day I worked in a high-rise bank, counting out pastel bundles of foreign cash bound first for branches and [...]

This paper presents the results of static and dynamic tests on unreinforced brick masonry wall panels subject to out-of-plane loading. Fourteen wall panels were tested. The test program included static, free-vibration, and dynamic tests using harmonic support, impulse support, and earthquake support motion. The experimental results indicate that displacement, rather than inertia force amplitude, determines whether an unreinforced masonry wall will collapse during inertial (seismic) loading. An empirical force-displacement relationship is proposed that can be used for a substitute structure in a displacement-based method of analysis. CE Database subject headings: Masonry; Earthquake loads; Flexure; Displacement; Walls; Panels.

EUDORA WELTY'S 'A PIECE OF NEWS,' a story originally published in these pages in 1937, seems at first glance to have an almost imbecilic premise. The dramatis personae are a [...]

Megakaryocyte-specific expression of the platelet-adhesion receptor, integrin [Alpha]IIb[Beta]3, is caused by the presence of regulatory elements of the [Alpha]IIb promoter that direct high-level, selective gene transcription early in megakaryocytopoiesis. To develop methods for targeted expression of transgenes, we transduced human CD34+ peripheral blood cells with a murine leukemia virus (MuLV) vector controlled by the human integrin [Alpha]IIb promoter (nucleotides -889 to +35). A naturally occurring cDNA encoding the [Pl.sup.A2] alloantigen form (Pro33) of the integrin [Beta]3 subunit was subcloned into this construct (-889[Pl.sup.A2][Beta]3) and transduced into cells that endogenously synthesized [pl.sup.A1][Beta]3 ([Leu.sub.33]) as a marker for detection of provirus-derived [Beta]3. The ability of this vector to target expression of [pl.sup.A2][Beta]3 to megakaryocytes was first examined in cell lines. Immunoblot analysis with human anti-[Pl.sup.A2] alloserum detected synthesis of [pl.sup.A2][Beta]3 in transduced promegakaryocytic cells; however, [Pl.sup.A2][Beta]3 protein was not detected in transduced epithelial cells. Human hematopoietic CD34+ cells were transduced with -889[Pl.sup.A2][Beta]3 virions and induced to differentiate with megakaryocyte growth and development factor. A hybrid [Alpha]IIb[Beta]3 complex was formed in progeny megakaryocytes where provirus-derived [pl.sup.A2][Beta]3 was detected associated with endogenous [Alpha]IIb subunit. Another [Alpha]IIb promoter-driven MuLV vector (-889nlacZ) encoding Escherichia coli [Beta]-galactosidase was used to demonstrate that transgene expression was selectively targeted to the megakaryocyte progeny of transduced CD34+ cells. These studies demonstrate the feasibility of using [Alpha]IIb promoter-driven MuLV vectors for gene transfer of hematopoietic CD34+ cells to target transgene expression in developing megakaryocytes and platelets and indicate potential applications toward human gene therapy for platelet disorders.

(cloth). Almost No Memory by Lydia Davis. New York: Farrar Straus Giroux. $21.00 'Do you see any affinity between hard drinking and the writing life? Explain.' Well, climb up on [...]

Hell by Kathryn Davis. Hopewell, NJ: Ecco Press. $22.00 (cloth). 'Do you see any affinity between hard drinking and the writing life? Explain.' Well, climb up on my knees here, [...]

(cloth). Bunny Modern by David Bowman. Boston: Little, Brown & Co. $21.95 (cloth). 'Do you see any affinity between hard drinking and the writing life? Explain.' Well, climb up on [...]

An Underachiever's Diary by Benjamin Anastas. New York: Dial Press. $15.95 'Do you see any affinity between hard drinking and the writing life? Explain.' Well, climb up on my knees [...]