142 results on '"Grecucci, Alessandro"'
Search Results
102. Editorial: Advances in Emotion Regulation: From Neuroscience to Psychotherapy
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Grecucci, Alessandro, primary, Frederickson, Jon, additional, and Job, Remo, additional
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- 2017
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103. How dare you not recognize the role of my contempt? Insight from experimental psychopathology
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Grecucci, Alessandro, primary, Frederickson, Jon, additional, and Job, Remo, additional
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- 2017
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104. Schema Therapy for Emotional Dysregulation: Theoretical Implication and Clinical Applications
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Dadomo, Harold, primary, Grecucci, Alessandro, additional, Giardini, Irene, additional, Ugolini, Erika, additional, Carmelita, Alessandro, additional, and Panzeri, Marta, additional
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- 2016
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105. Mindful Emotion Regulation: Exploring the Neurocognitive Mechanisms behind Mindfulness
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Grecucci, Alessandro, Pappaianni, Edoardo, Siugzdaite, Roma, Theuninck, Anthony, and Job, Remo
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Article Subject - Abstract
The purpose of this paper is to review some of the psychological and neural mechanisms behind mindfulness practice in order to explore the unique factors that account for its positive impact on emotional regulation and health. After reviewing the mechanisms of mindfulness and its effects on clinical populations we will consider how the practice of mindfulness contributes to the regulation of emotions. We argue that mindfulness has achieved effective outcomes in the treatment of anxiety, depression, and other psychopathologies through the contribution of mindfulness to emotional regulation. We consider the unique factors that mindfulness meditation brings to the process of emotion regulation that may account for its effectiveness. We review experimental evidence that points towards the unique effects of mindfulness specifically operating over and above the regulatory effects of cognitive reappraisal mechanisms. A neuroanatomical circuit that leads to mindful emotion regulation is also suggested. This paper thereby aims to contribute to proposed models of mindfulness for research and theory building by proposing a specific model for the unique psychological and neural processes involved in mindful detachment that account for the effects of mindfulness over and above the effects accounted for by other well-established emotional regulation processes such as cognitive reappraisal.
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- 2015
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106. Uncovering the Social Deficits in the Autistic Brain. A Source-Based Morphometric Study
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Grecucci, Alessandro, primary, Rubicondo, Danilo, additional, Siugzdaite, Roma, additional, Surian, Luca, additional, and Job, Remo, additional
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- 2016
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107. An Abnormal Cerebellar Network in Children with Autistic Spectrum Disorder: A Morphometric Study
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Pappaianni, Edoardo, primary and Grecucci, Alessandro, additional
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- 2016
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108. How expectations and their violations affect decision making
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Giorgetta Cinzia (a), Grecucci Alessandro (b), Ferrario Roberta (a), Bonini Nicolao (c), and Sanfey Alan (d) (e)
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- 2013
109. Three shades of grey: detecting brain abnormalities in children with autism using source‐, voxel‐ and surface‐based morphometry.
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Pappaianni, Edoardo, Siugzdaite, Roma, Vettori, Sofie, Venuti, Paola, Job, Remo, and Grecucci, Alessandro
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CHILDREN with autism spectrum disorders ,GRAY matter (Nerve tissue) ,MORPHOMETRICS ,STEREOTYPY (Psychiatry) ,SOCIAL interaction - Abstract
Abstract: Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interactions, communication and stereotyped behaviour. Recent evidence from neuroimaging supports the hypothesis that ASD deficits in adults may be related to abnormalities in a specific frontal–temporal network [Autism‐specific Structural Network (ASN)]. To see whether these results extend to younger children and to better characterize these abnormalities, we applied three morphometric methods on brain grey matter (GM) of children with and without ASD. We selected 39 sMRI images of male children with ASD and 42 typically developing (TD) from the Autism Brain Imaging Data Exchange database. We used source‐based morphometry (SoBM), a whole‐brain multivariate approach to identify GM networks, voxel‐based morphometry (VBM), a voxel‐wise comparison of the local GM concentration and surface‐based morphometry (SuBM) for the estimation of the cortical parameters. SoBM showed a bilateral frontal–parietal–temporal network different between groups, including the inferior–middle temporal gyrus, the inferior parietal lobule and the postcentral gyrus; VBM returned differences only in the right temporal lobe; SuBM returned a thinning in the right inferior temporal lobe thinner in ASD, a higher gyrification in the right superior parietal lobule in TD and in the middle frontal gyrus in ASD. For the first time, we investigated the brain abnormalities in children with ASD using three morphometric techniques. The results were relatively consistent between methods, stressing the role of an Autism‐specific Structural Network in ASD individuals. We also make methodological speculations on the relevance of using multivariate and whole‐brain neuroimaging analysis to capture ASD complexity. [ABSTRACT FROM AUTHOR]
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- 2018
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110. Neurocognitive mechanisms of the emotional control of imitation
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Grecucci, Alessandro
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- 2010
111. Baseline and Strategic Effects behind Mindful Emotion Regulation: Behavioral and Physiological Investigation
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Grecucci, Alessandro, primary, De Pisapia, Nicola, additional, Kusalagnana Thero, Derangala, additional, Paladino, Maria Paola, additional, Venuti, Paola, additional, and Job, Remo, additional
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- 2015
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112. Rethinking reappraisal: Insights from affective neuroscience
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Grecucci, Alessandro, primary and Job, Remo, additional
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- 2015
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113. Vicarious Function in the Motor Cortex. A Computational Investigation
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Grecucci, Alessandro, Crescentini, Cristiano, and Siugzdaite, Roma
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- 2008
114. Towards a Psychology in Shades of Grey. An Epistemological Analysis.
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Castellana, Mario, Chiffi, Daniele, and Grecucci, Alessandro
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EXPLANATION ,PSYCHOLOGY surveys ,LITERARY explication ,PSYCHOMETRICS ,PSYCHOLOGY - Abstract
Copyright of International Journal of Psychoanalysis & Education is the property of International Journal of Psychoanalysis & Education and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2017
115. Time Devours Things: How Impulsivity and Time Affect Temporal Decisions in Pathological Gamblers
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Grecucci, Alessandro, primary, Giorgetta, Cinzia, additional, Rattin, Andrea, additional, Guerreschi, Cesare, additional, Sanfey, Alan G., additional, and Bonini, Nicolao, additional
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- 2014
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116. Anxious ultimatums: How anxiety disorders affect socioeconomic behaviour
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Grecucci, Alessandro, primary, Giorgetta, Cinzia, additional, Brambilla, Paolo, additional, Zuanon, Sophia, additional, Perini, Laura, additional, Balestrieri, Matteo, additional, Bonini, Nicolao, additional, and Sanfey, Alan G., additional
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- 2013
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117. Reappraising social emotions: the role of inferior frontal gyrus, temporo-parietal junction and insula in interpersonal emotion regulation
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Grecucci, Alessandro, primary, Giorgetta, Cinzia, additional, Bonini, Nicolao, additional, and Sanfey, Alan G., additional
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- 2013
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118. Living Emotions, Avoiding Emotions: Behavioral Investigation of the Regulation of Socially Driven Emotions
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Grecucci, Alessandro, primary, Giorgetta, Cinzia, additional, Bonini, Nicolao, additional, and Sanfey, Alan G., additional
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- 2013
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119. Per una metodologia della regolazione emozionale basata su principi psicodinamici.
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Grecucci, Alessandro, Recchia, Luca, and Frederickson, Jon
- Abstract
Copyright of International Journal of Psychoanalysis & Education is the property of International Journal of Psychoanalysis & Education and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2016
120. Emotional Resonance Deficits in Autistic Children
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Grecucci, Alessandro, primary, Brambilla, Paolo, additional, Siugzdaite, Roma, additional, Londero, Danielle, additional, Fabbro, Franco, additional, and Rumiati, Raffaella Ida, additional
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- 2012
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121. The effect of observed biological and non biological movements on action imitation: An fMRI study
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Crescentini, Cristiano, primary, Mengotti, Paola, additional, Grecucci, Alessandro, additional, and Rumiati, Raffaella Ida, additional
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- 2011
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122. Vicarious function in the motor cortex
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Grecucci, Alessandro, primary, Crescentini, Cristiano, additional, and Siugzdaite, Roma, additional
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- 2008
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123. Difficulties in interpersonal regulation of emotions (DIRE) questionnaire: Psychometric Properties of the Italian Version and Associations with psychopathological symptoms.
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Messina, Irene, Spataro, Pietro, Grecucci, Alessandro, Marogna, Cristina, and Dixon-Gordon, Katherine L.
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RESEARCH methodology evaluation , *RESEARCH methodology , *PSYCHOMETRICS , *QUESTIONNAIRES , *PATHOLOGICAL psychology , *INTERPERSONAL relations , *EMOTION regulation - Abstract
The goal of this research was to validate an Italian adaptation of the questionnaire Difficulties in Interpersonal Regulation of Emotions (DIRE) and to investigate its associations with psychopathology. An Italian sample (N = 630) completed the DIRE and the Symptom Checklist-90 (SCL-90). We tested the factorial structure of the DIRE using explorative and confirmatory factorial analyses; we analysed the convergent validity in terms of zero-order correlations with SCL-90 dimensions; and, we conducted multiple regressions to test the predictivity of DIRE factors on specific SCL-90 dimensions. The Italian DIRE replicated the four-factor structure of the original measure, with two interpersonal (Vent and Reassurance-seek) and two intrapersonal (Accept and Avoid) factors. Interpersonal factors resulted correlated with SCL-90 global indexes of psychopathology. Moreover, specific association between DIRE factors and SCL-90 dimensions were found. The Italian DIRE is a reliable and valid measure to evaluate clinically-relevant forms of emotion dysregulation. [ABSTRACT FROM AUTHOR]
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- 2022
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124. The phobic brain: Morphometric features correctly classify individuals with small animal phobia.
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Scarano, Alessandro, Fumero, Ascensión, Baggio, Teresa, Rivero, Francisco, Marrero, Rosario J., Olivares, Teresa, Peñate, Wenceslao, Álvarez‐Pérez, Yolanda, Bethencourt, Juan Manuel, and Grecucci, Alessandro
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SUPPORT vector machines , *GRAY matter (Nerve tissue) , *ANXIETY disorders , *FRONTAL lobe , *AFFECTIVE neuroscience , *PHOBIAS - Abstract
Specific phobia represents an anxiety disorder category characterized by intense fear generated by specific stimuli. Among specific phobias, small animal phobia (SAP) denotes a particular condition that has been poorly investigated in the neuroscientific literature. Moreover, the few previous studies on this topic have mostly employed univariate analyses, with limited and unbalanced samples, leading to inconsistent results. To overcome these limitations, and to characterize the neural underpinnings of SAP, this study aims to develop a classification model of individuals with SAP based on gray matter features, by using a machine learning method known as the binary support vector machine. Moreover, the contribution of specific structural macro‐networks, such as the default mode, the salience, the executive, and the affective networks, in separating phobic subjects from controls was assessed. Thirty‐two subjects with SAP and 90 matched healthy controls were tested to this aim. At a whole‐brain level, we found a significant predictive model including brain structures related to emotional regulation, cognitive control, and sensory integration, such as the cerebellum, the temporal pole, the frontal cortex, temporal lobes, the amygdala and the thalamus. Instead, when considering macro‐networks analysis, we found the Default, the Affective, and partially the Central Executive and the Sensorimotor networks, to significantly outperform the other networks in classifying SAP individuals. In conclusion, this study expands knowledge about the neural basis of SAP, proposing new research directions and potential diagnostic strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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125. Resting-state BOLD temporal variability in sensorimotor and salience networks underlies trait emotional intelligence and explains differences in emotion regulation strategies.
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Zanella, Federico, Monachesi, Bianca, and Grecucci, Alessandro
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SALIENCE network , *LARGE-scale brain networks , *EMOTIONAL intelligence , *EMOTION regulation , *INDEPENDENT component analysis , *SENSORIMOTOR cortex - Abstract
A converging body of behavioural findings supports the hypothesis that the dispositional use of emotion regulation (ER) strategies depends on trait emotional intelligence (trait EI) levels. Unfortunately, neuroscientific investigations of such relationship are missing. To fill this gap, we analysed trait measures and resting state data from 79 healthy participants to investigate whether trait EI and ER processes are associated to similar neural circuits. An unsupervised machine learning approach (independent component analysis) was used to decompose resting-sate functional networks and to assess whether they predict trait EI and specific ER strategies. Individual differences results showed that high trait EI significantly predicts and negatively correlates with the frequency of use of typical dysfunctional ER strategies. Crucially, we observed that an increased BOLD temporal variability within sensorimotor and salience networks was associated with both high trait EI and the frequency of use of cognitive reappraisal. By contrast, a decreased variability in salience network was associated with the use of suppression. These findings support the tight connection between trait EI and individual tendency to use functional ER strategies, and provide the first evidence that modulations of BOLD temporal variability in specific brain networks may be pivotal in explaining this relationship. [ABSTRACT FROM AUTHOR]
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- 2022
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126. Do anger perception and the experience of anger share common neural mechanisms? Coordinate-based meta-analytic evidence of similar and different mechanisms from functional neuroimaging studies.
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Sorella, Sara, Grecucci, Alessandro, Piretti, Luca, and Job, Remo
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TEMPORAL lobe , *ANGER , *FUSIFORM gyrus , *EMOTIONS , *PREFRONTAL cortex - Abstract
• This meta-analysis explores the neural bases of anger perception and experience. • Anger perception relies on the amygdala, the FFG, the STG and the right IFG. • Anger experience relies on the bilateral insula and ventrolateral PFC. • A common activation of the right IFG may involve emotional conceptualization. The neural bases of anger are still a matter of debate. In particular we do not know whether anger perception and anger experience rely on similar or different neural mechanisms. To study this topic, we performed activation-likelihood-estimation meta-analyses of human neuroimaging studies on 61 previous studies on anger perception and experience. Anger perception analysis resulted in significant activation in the amygdala, the right superior temporal gyrus, the right fusiform gyrus and the right IFG, thus revealing the role of perceptual temporal areas for perceiving angry stimuli. Anger experience analysis resulted in the bilateral activations of the insula and the ventrolateral prefrontal cortex, thus revealing a role for these areas in the subjective experience of anger and, possibly, in a subsequent evaluation of the situation. Conjunction analyses revealed a common area localized in the right inferior frontal gyrus, probably involved in the conceptualization of anger for both perception and experience. Altogether these results provide new insights on the functional architecture underlying the neural processing of anger that involves separate and joint mechanisms. According to our tentative model, angry stimuli are processed by temporal areas, such as the superior temporal gyrus, the fusiform gyrus and the amygdala; on the other hand, the subjective experience of anger mainly relies on the anterior insula; finally, this pattern of activations converges in the right IFG. This region seems to play a key role in the elaboration of a general meaning of this emotion, when anger is perceived or experienced. [ABSTRACT FROM AUTHOR]
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- 2021
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127. Automatic Detection of a Student's Affective States for Intelligent Teaching Systems.
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Myers, Mark H. and Grecucci, Alessandro
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AFFECT (Psychology) , *EMOTIONAL state , *EMOTIONS , *EXTRACTION techniques , *FEATURE extraction , *PEER teaching - Abstract
AutoTutor is an automated computer tutor that simulates human tutors and holds conversations with students in natural language. Using data collected from AutoTutor, the following determinations were sought: Can we automatically classify affect states from intelligent teaching systems to aid in the detection of a learner's emotional state? Using frequency patterns of AutoTutor feedback and assigned user emotion in a series of pairs, can the next pair of feedback/emotion series be predicted? Through a priori data mining approaches, we found dominant frequent item sets that predict the next set of responses. Thirty-four participants provided 200 turns between the student and the AutoTutor. Two series of attributes and emotions were concatenated into one row to create a record of previous and next set of emotions. Feature extraction techniques, such as multilayer-perceptron and naive Bayes, were performed on the dataset to perform classification for affective state labeling. The emotions 'Flow' and 'Frustration' had the highest classification of all the other emotions when measured against other emotions and their respective attributes. The most common frequent item sets were 'Flow' and 'Confusion'. [ABSTRACT FROM AUTHOR]
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- 2021
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128. The Effect of Centralized Financial and Social Incentives on Cooperative Behavior and Its Underlying Neural Mechanisms.
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Micheli, Leticia, Stallen, Mirre, Sanfey, Alan G., and Grecucci, Alessandro
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INCENTIVE (Psychology) ,MONETARY incentives ,PUBLIC goods ,FUNCTIONAL magnetic resonance imaging - Abstract
Incentives are frequently used by governments and employers to encourage cooperation. Here, we investigated the effect of centralized incentives on cooperation, firstly in a behavioral study and then replicated in a subsequent neuroimaging (fMRI) study. In both studies, participants completed a novel version of the Public Goods Game, including experimental conditions in which the administration of centralized incentives was probabilistic and incentives were either of a financial or social nature. Behavioral results showed that the prospect of potentially receiving financial and social incentives significantly increased cooperation, with financial incentives yielding the strongest effect. Neuroimaging results showed that activation in the bilateral lateral orbitofrontal cortex and precuneus increased when participants were informed that incentives would be absent versus when they were present. Furthermore, activation in the medial orbitofrontal cortex increased when participants would potentially receive a social versus a financial incentive. These results speak to the efficacy of different types of centralized incentives in increasing cooperative behavior, and they show that incentives directly impact the neural mechanisms underlying cooperation. [ABSTRACT FROM AUTHOR]
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- 2021
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129. Motivated Interpretations of Deceptive Information.
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Vainapel, Sigal, Shani, Yaniv, Shalvi, Shaul, and Grecucci, Alessandro
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BEHAVIORAL ethics ,MORAL judgment ,CORPORATE profits - Abstract
We examine whether people seek information that might help them make sense of others' dishonest behavior. Participants were told that a hypothetical partner (either a friend or a stranger) had engaged in a task in which the partner could lie to boost their earnings at the expense of the participant's earnings. Participants were less likely to search for information that can justify potential dishonest behavior conducted by a friend than by a stranger (Experiment 1). When participants knew for certain that their partners had lied to them, they were less likely to assume that that the lie was justified when told that the partner was a friend rather than a stranger (Experiment 2). The results imply that people are more likely to search for information that may reduce the severity of possible dishonest behavior when a stranger, rather than a friend, is responsible for the behavior. [ABSTRACT FROM AUTHOR]
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- 2021
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130. Evidence for lateralized functional connectivity patterns at rest related to the tendency of externalizing or internalizing anger.
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Consolini, Jennifer, Sorella, Sara, and Grecucci, Alessandro
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FUNCTIONAL connectivity , *FRONTAL lobe , *PREFRONTAL cortex , *RESPONSE inhibition , *ANGER , *ANGER management - Abstract
Previous electroencephalographic and brain stimulation studies have shown that anger responses may be differently lateralized in the prefrontal cortex, with outward-oriented responses (externalized anger) linked to left prefrontal activity, and inward-oriented responses (internalized anger) linked to right prefrontal activity. However, the specific neural structures involved in this asymmetry, and how they interact to produce individual differences, remain unexplored. Furthermore, it is unclear whether such asymmetry may be explained by general behavioral tendencies, known as Behavioral Activation and Behavioral Inhibition Systems (BIS/BAS). Therefore, we analyzed the tendency of externalizing and internalizing anger, respectively measured by the Anger-Out and Anger-In subscales of the State-Trait Anger Expression Inventory, with the patterns of functional connectivity at rest of 71 participants. A left, prefrontal, resting-state, functional connectivity pattern was found for externalizing anger (Anger-Out), including the left inferior frontal gyrus and the left frontal eye fields. By contrast, a right, prefrontal, resting-state, functional connectivity pattern was found for internalizing anger (Anger-In), including the rostral and lateral prefrontal cortex, the orbitofrontal cortex, the frontal pole, the superior, middle and inferior frontal gyri, and the anterior cingulate. Notably, these patterns were not associated with the BIS/BAS scores. In this study, for the first time, we provide evidence using fMRI functional connectivity for two specific lateralized circuits contributing to individual differences in externalizing and internalizing anger. These results confirm and extend the asymmetry hypothesis for anger and have notable implications in the treatment of anger-related problems. [ABSTRACT FROM AUTHOR]
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- 2022
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131. Narcissus reflected: Grey and white matter features joint contribution to the default mode network in predicting narcissistic personality traits.
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Jornkokgoud, Khanitin, Baggio, Teresa, Bakiaj, Richard, Wongupparaj, Peera, Job, Remo, and Grecucci, Alessandro
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DEFAULT mode network , *PERSONALITY , *MACHINE learning , *SUPERVISED learning , *GRAY matter (Nerve tissue) , *WHITE matter (Nerve tissue) , *LARGE-scale brain networks - Abstract
Despite the clinical significance of narcissistic personality, its neural bases have not been clarified yet, primarily because of methodological limitations of the previous studies, such as the low sample size, the use of univariate techniques and the focus on only one brain modality. In this study, we employed for the first time a combination of unsupervised and supervised machine learning methods, to identify the joint contributions of grey matter (GM) and white matter (WM) to narcissistic personality traits (NPT). After preprocessing, the brain scans of 135 participants were decomposed into eight independent networks of covarying GM and WM via parallel ICA. Subsequently, stepwise regression and Random Forest were used to predict NPT. We hypothesized that a fronto‐temporo parietal network, mainly related to the default mode network, may be involved in NPT and associated WM regions. Results demonstrated a distributed network that included GM alterations in fronto‐temporal regions, the insula and the cingulate cortex, along with WM alterations in cerebellar and thalamic regions. To assess the specificity of our findings, we also examined whether the brain network predicting narcissism could also predict other personality traits (i.e., histrionic, paranoid and avoidant personalities). Notably, this network did not predict such personality traits. Additionally, a supervised machine learning model (Random Forest) was used to extract a predictive model for generalization to new cases. Results confirmed that the same network could predict new cases. These findings hold promise for advancing our understanding of personality traits and potentially uncovering brain biomarkers associated with narcissism. [ABSTRACT FROM AUTHOR]
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- 2024
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132. Neurochemical correlates of brain atrophy in fibromyalgia syndrome: a magnetic resonance spectroscopy and cortical thickness study
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Paola Feraco 1, 2, Salvatore Nigro 3, Luca Passamonti 4, 5, Alessandro Grecucci 6, Maria Eugenia Caligiuri 3, Cesare Gagliardo 7, Antonella Bacci 8, Feraco, Paola [0000-0002-3707-018X], Grecucci, Alessandro [0000-0001-6043-2196], Caligiuri, Maria Eugenia [0000-0002-2030-5552], Gagliardo, Cesare [0000-0003-4088-2020], Apollo - University of Cambridge Repository, Feraco, Paola, Nigro, Salvatore, Passamonti, Luca, Grecucci, Alessandro, Caligiuri, Maria Eugenia, Gagliardo, Cesare, and Bacci, Antonella
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In vivo magnetic resonance spectroscopy ,medicine.medical_specialty ,brain MRI ,Article ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Neurochemical ,Atrophy ,Neuroimaging ,Gyrus ,Fibromyalgia ,Internal medicine ,medicine ,cortical thickne ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,030304 developmental biology ,0303 health sciences ,business.industry ,General Neuroscience ,MR spectroscopy ,Glutamate receptor ,Settore MED/37 - Neuroradiologia ,cortical thickness ,medicine.disease ,Subcortical gray matter ,Endocrinology ,medicine.anatomical_structure ,fibromyalgia ,glutamate excitotoxicity ,chronic pain ,Settore MED/36 - Diagnostica Per Immagini E Radioterapia ,business ,030217 neurology & neurosurgery - Abstract
(1) Background: Recently, a series of clinical neuroimaging studies on fibromyalgia (FM) have shown a reduction in cortical volume and abnormally high glutamate (Glu) and glutamate + glutamine (Glx) levels in regions associated with pain modulation. However, it remains unclear whether the volumetric decreases and increased Glu levels in FM are related each other. We hypothesized that higher Glu levels are related to decreases in cortical thickness (CT) and volume in FM patients. (2) Methods: Twelve females with FM and 12 matched healthy controls participated in a session of combined 3.0 Tesla structural magnetic resonance imaging (MRI) and single-voxel MR spectroscopy focused on the thalami and ventrolateral prefrontal cortices (VLPFC). The thickness of the cortical and subcortical gray matter structures and the Glu/Cr and Glx/Cr ratios were estimated. Statistics included an independent t-test and Spearman&rsquo, s test. (3) Results: The Glu/Cr ratio of the left VLPFC was negatively related to the CT of the left inferior frontal gyrus (pars opercularis (p = 0.01, r = &minus, 0.75) and triangularis (p = 0.01, 0.70)). Moreover, the Glx/Cr ratio of the left VLPFC was negatively related to the CT of the left middle anterior cingulate gyrus (p = 0.003, 0.81). Significantly lower CTs in FM were detected in subparts of the cingulate gyrus on both sides and in the right inferior occipital gyrus (p <, 0.001). (4) Conclusions: Our findings are in line with previous observations that high glutamate levels can be related, in a concentration-dependent manner, to the morphological atrophy described in FM patients.
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- 2020
133. How sexual objectification marks the brain: fMRI evidence of self-objectification and its harmful emotional consequences.
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Monachesi, Bianca, Deruti, Alice, Vaes, Jeroen, Leoni, Paolo, and Grecucci, Alessandro
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SEXUAL objectification , *TEMPORAL lobe , *SOCIAL processes , *SOCIAL dynamics , *EMOTIONS , *SHAME - Abstract
• We explored brain correlates of self-objectification and related emotional response. • Neural activity was recorder in 25 women exposed to objectifying interactions. • Being objectified increased activity in cortical and subcortical brain regions. • Self-objectification tendency and shame response increased activity in the caudate. • Importance of neuroscientific perspective for understanding toxic social dynamic. Female Sexual Objectification refers to perceiving and treating women based on their body appearance. This phenomenon may serve as a precursor for dysfunctional behaviors, particularly among females prone to self -objectification and experiencing shame emotions. Understanding this challenging trajectory by disclosing its neural consequences may be crucial for comprehending extreme psychopathological outcomes. However, investigations in this sense are still scarce. The present study explores the neural correlates of female participants' experiences of being objectified and their relationship with self-objectification, emotional responses and individual dispositions in self-esteem, emotion regulation abilities and self-conscious emotion proneness. To this aim, 25 female participants underwent an fMRI experimental session while they were exposed to interpersonal encounters with objectifying or non-objectifying men. Participants' experienced emotions and levels of attention shifted toward their bodies (self-objectification) was reported after each interaction. The results revealed increased brain activity in objectifying contexts, impacting cortical (frontal, occipital and temporal cortex) and subcortical regions (thalamus, and hippocampus) involved in visual, emotion, and social processing. Remarkably, the inferior temporal gyrus emerged as a crucial neural hub associated in opposite ways with self-esteem and the self-conscious emotion of shame, highlighting its role in self-referential processing during social dynamics. This study points out the importance of adopting a neuroscientific perspective for a deeper understanding of sexual objectification, and to shed light on its possible neural consequences. [ABSTRACT FROM AUTHOR]
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- 2024
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134. Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder.
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Xiao, Qian, Shen, Liying, He, Haoling, Wang, Xueying, Fu, Yan, Ding, Jun, Jiang, Furong, Zhang, Jinfan, Zhang, Zhejia, Grecucci, Alessandro, Yi, Xiaoping, and Chen, Bihong T.
- Abstract
The neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. The study aimed to assess the alterations in neural activity within prefrontal cortex in adolescents with BPD and investigate the relationship of prefrontal activity with emotional regulation and cognitive function. This study enrolled 50 adolescents aged 12–17 years with BPD and 21 gender and age-matched healthy control (HC) participants. Study assessment for each participant included a brain resting-state functional MRI (rs-fMRI), clinical assessment questionnaires such as Borderline Personality Features Scale (BPFS), Difficulties in Emotion Regulation Scale (DERS), Ottawa Self-Injury Inventory and Childhood Trauma Questionnaire (CTQ) and cognitive testing with Stroop Color-Word Test (SCWT). Fractional amplitude of low-frequency fluctuations (fALFF) and seed-based functional connectivity (FC) were obtained from rs-fMRI analysis. Correlation analysis was also performed to evaluate the associations of the neuroimaging metrics such as fALFF and FC with clinical assessment questionnaire and cognitive testing scores. Adolescents with BPD showed increased fALFF values in the right inferior frontal gyrus and decreased activity in the left middle frontal gyrus as compared to the HC group (
p < 0.05, cluster size ≥ 100, FWE correction). In adolescents with BPD, increased fALFF in the right inferior frontal gyrus was related to the BPFS (emotional dysregulation), DERS-F (lacking of emotional regulation strategies) and Ottawa Self-Injury Inventory-4 C scores (internal emotional regulation function of self-injurious behavior). The reduced fALFF in the left middle frontal gyrus was associated with the SCWT-A (reading characters) and the SCWT-B (reading color) scores. Additionally, the fALFF values in the left middle frontal gyrus and the right inferior frontal gyrus were related to the CTQ-D (emotional neglect) (p < 0.05). The left middle frontal gyrus exhibited increased FC with the right hippocampus, left inferior temporal gyrus and right inferior frontal gyrus (voxelp < 0.001, clusterp < 0.05, FWE correction). The increased FC between the left middle frontal gyrus and the right hippocampus was related to the SCWT-C (cognitive flexibility) score. We observed diverging changes in intrinsic brain activity in prefrontal cortex, and neural compensatory changes to maintain function in adolescents with BPD. In addition, decreased neural function was closely associated with emotional dysregulation, while increased neural function as indicated by brain activity and FC was associated with cognitive dysfunction. These results indicated that alterations of intrinsic brain activity may be one of the underlying neurobiological markers for clinical symptoms in adolescents with BPD. [ABSTRACT FROM AUTHOR]- Published
- 2024
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135. Structural and functional brain networks of individual differences in trait anger and anger control: an unsupervised machine learning study
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Alessandro Grecucci, Roma Siugzdaite, Valentina Vellani, Sara Sorella, Paola Feraco, Sorella, Sara, Vellani, Valentina, Siugzdaite, Roma, Feraco, Paola, Grecucci, Alessandro, Sorella, Sara [0000-0001-6080-9467], and Apollo - University of Cambridge Repository
- Subjects
trait anger ,media_common.quotation_subject ,Individuality ,Hostility ,Anger ,behavioral disciplines and activities ,trait anger, anger control, machine learning, resting state, sourcebased morphometry, brain networks ,anger control ,Neural Pathways ,mental disorders ,medicine ,Humans ,resting state ,trait anger, anger control, machine learning, resting state, source-based morphometry, brain networks ,Default mode network ,media_common ,Brain Mapping ,Fusiform gyrus ,Resting state fMRI ,General Neuroscience ,Brain ,Cognition ,brain networks ,Magnetic Resonance Imaging ,machine learning ,Posterior cingulate ,Trait ,behavior and behavior mechanisms ,source-based morphometry ,medicine.symptom ,Psychology ,psychological phenomena and processes ,Cognitive psychology ,Unsupervised Machine Learning - Abstract
The ability to experience, use and eventually control anger is crucial to maintain well-being and build healthy relationships. Despite its relevance, the neural mechanisms behind individual differences in experiencing and controlling anger are poorly understood. To elucidate these points, we employed an unsupervised machine learning approach based on independent component analysis to test the hypothesis that specific functional and structural networks are associated with individual differences in trait anger and anger control. Structural and functional resting state images of 71 subjects as well as their scores from the State-Trait Anger Expression Inventory entered the analyses. At a structural level, the concentration of grey matter in a network including ventromedial temporal areas, posterior cingulate, fusiform gyrus and cerebellum was associated with trait anger. The higher the concentration, the higher the proneness to experience anger in daily life due to the greater tendency to orient attention towards aversive events and interpret them with higher hostility. At a functional level, the activity of the default mode network (DMN) was associated with anger control. The higher the DMN temporal frequency, the stronger the exerted control over anger, thus extending previous evidence on the role of the DMN in regulating cognitive and emotional functions in the domain of anger. Taken together, these results show, for the first time, two specialized brain networks for encoding individual differences in trait anger and anger control.
- Published
- 2021
136. Predicting dropout and non-response to psychotherapy for personality disorders: A study protocol focusing on therapist, patient, and the therapeutic relationship.
- Author
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De Salve F, Rossi C, Messina I, Grecucci A, Falgares G, Infurna MR, and Oasi O
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- Humans, Longitudinal Studies, Adult, Professional-Patient Relations, Male, Therapeutic Alliance, Female, Patient Dropouts statistics & numerical data, Patient Dropouts psychology, Personality Disorders therapy, Psychotherapy methods, Psychotherapy statistics & numerical data
- Abstract
Background: The abandonment of psychotherapeutic treatments is influenced by various factors, including patient characteristics, therapist traits, and the therapeutic relationship. Despite the well-documented importance of these factors, limited empirical research has focused on the role of the therapeutic relationship and the characteristics of therapist-patient dyads in predicting treatment dropout. This study protocol outlines a longitudinal research project aimed at predicting dropout and non-response in psychotherapy for individuals with personality disorders. The research seeks to identify predictive factors related to psychotherapy outcomes, focusing on patient, therapist, and dyadic elements. Specifically, the study will examine the influence of therapist characteristics (e.g., personality traits, countertransference, responsiveness) on treatment outcomes, explore the impact of relational factors (e.g., treatment expectations, epistemic trust, therapeutic alliance) on therapy effectiveness, and assess how the therapeutic alliance within therapist-patient dyads affects the likelihood of dropout and non-response., Methods: The longitudinal study will include 100 therapist-patient dyads (200 participants) recruited from various Mental Health Services in Milan, Italy. Validated instruments will be administered to both patients and therapists at four-time points: T0 (baseline), T1 (3 months), T2 (6 months), and T3 (1 year). Data will be collected at baseline and at the one-year mark to evaluate the relationships between therapist, patient, and dyadic factors and treatment outcomes., Discussion: Identifying predictive variables associated with high dropout rates can help preempt treatment discontinuation, reducing the financial and operational burdens on mental health services. Understanding these factors will enable the development of targeted interventions to improve treatment engagement and reduce attrition. This approach could enhance outcomes for individuals with personality disorders and lead to more efficient resource allocation and sustainable delivery of mental health care., (© 2024. The Author(s).)
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- 2024
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137. Decoding acceptance and reappraisal strategies from resting state macro networks.
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Ahmadi Ghomroudi P, Siugzdaite R, Messina I, and Grecucci A
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- Humans, Female, Male, Adult, Young Adult, Nerve Net physiology, Nerve Net diagnostic imaging, Emotional Regulation physiology, Emotions physiology, Rest physiology, Brain Mapping methods, Cognition physiology, Magnetic Resonance Imaging methods, Brain physiology, Brain diagnostic imaging
- Abstract
Acceptance and reappraisal are considered adaptive emotion regulation strategies. While previous studies have explored the neural underpinnings of these strategies using task-based fMRI and sMRI, a gap exists in the literature concerning resting-state functional brain networks' contributions to these abilities, especially regarding acceptance. Another intriguing question is whether these strategies rely on similar or different neural mechanisms. Building on the well-known improved emotion regulation and increased cognitive flexibility of individuals who rely on acceptance, we expected to find decreased activity inside the affective network and increased activity inside the executive and sensorimotor networks to be predictive of acceptance. We also expect that these networks may be associated at least in part with reappraisal, indicating a common mechanism behind different strategies. To test these hypotheses, we conducted a functional connectivity analysis of resting-state data from 134 individuals (95 females; mean age: 30.09 ± 12.87 years, mean education: 12.62 ± 1.41 years). To assess acceptance and reappraisal abilities, we used the Cognitive Emotion Regulation Questionnaire (CERQ) and a group-ICA unsupervised machine learning approach to identify resting-state networks. Subsequently, we conducted backward regression to predict acceptance and reappraisal abilities. As expected, results indicated that acceptance was predicted by decreased affective, and executive, and increased sensorimotor networks, while reappraisal was predicted by an increase in the sensorimotor network only. Notably, these findings suggest both distinct and overlapping brain contributions to acceptance and reappraisal strategies, with the sensorimotor network potentially serving as a core common mechanism. These results not only align with previous findings but also expand upon them, illustrating the complex interplay of cognitive, affective, and sensory abilities in emotion regulation., (© 2024. The Author(s).)
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- 2024
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138. Attachment orientations and emotion regulation: new insights from the study of interpersonal emotion regulation strategies.
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Messina I, Calvo V, and Grecucci A
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A crucial point for the understanding of the link between attachment and emotion regulation concerns the individual tendency in turning to others to alleviate distress. Most previous studies in this field have considered almost exclusively intra-personal forms of emotion regulation, neglecting the role of social interaction in emotion regulation processes. In the present study, instead, we focused on interpersonal emotion regulation. 630 adults were assessed for their attachment orientations, general difficulties in emotion regulation, and habitual intra-personal and interpersonal emotion regulation strategies. Results showed that the imbalance between the hyper-activation and deactivation of the attachment system, which characterize unsecure attachment, reflects a correspondent imbalance in the use of emotion regulation strategies, with an exaggerated dependence on other associated with attachment anxiety and pseudo-autonomy associated to attachment avoidance.
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- 2023
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139. Decoding reappraisal and suppression from neural circuits: A combined supervised and unsupervised machine learning approach.
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Ghomroudi PA, Scaltritti M, and Grecucci A
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- Humans, Brain diagnostic imaging, Cerebral Cortex physiology, Anxiety, Magnetic Resonance Imaging, Emotions physiology, Unsupervised Machine Learning, Emotional Regulation physiology
- Abstract
Emotion regulation is a core construct of mental health and deficits in emotion regulation abilities lead to psychological disorders. Reappraisal and suppression are two widely studied emotion regulation strategies but, possibly due to methodological limitations in previous studies, a consistent picture of the neural correlates related to the individual differences in their habitual use remains elusive. To address these issues, the present study applied a combination of unsupervised and supervised machine learning algorithms to the structural MRI scans of 128 individuals. First, unsupervised machine learning was used to separate the brain into naturally grouping grey matter circuits. Then, supervised machine learning was applied to predict individual differences in the use of different strategies of emotion regulation. Two predictive models, including structural brain features and psychological ones, were tested. Results showed that a temporo-parahippocampal-orbitofrontal network successfully predicted the individual differences in the use of reappraisal. Differently, insular and fronto-temporo-cerebellar networks successfully predicted suppression. In both predictive models, anxiety, the opposite strategy, and specific emotional intelligence factors played a role in predicting the use of reappraisal and suppression. This work provides new insights regarding the decoding of individual differences from structural features and other psychologically relevant variables while extending previous observations on the neural bases of emotion regulation strategies., (© 2023. The Author(s).)
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- 2023
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140. Electrophysiological, emotional and behavioural responses of female targets of sexual objectification.
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Monachesi B, Deruti A, Grecucci A, and Vaes J
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- Female, Humans, Sexual Behavior psychology, Emotions, Shame, Self Concept, Body Image psychology
- Abstract
Sexual objectification and the interiorized objectifying gaze (self-objectification) are dangerous phenomena for women's psychological wellness. However, their specific effects on women's socio-affective reactions are still poorly understood, and their neural activity has never been explored before. In the present study, we investigated women's emotional and electrophysiological responses during simulated computer-based objectifying social interactions, and we examined consequent punishing behaviours towards the perpetrator using the ultimatum game. Behavioural results (N = 36) showed that during objectifying encounters women generally felt angrier/disgusted and tended to punish the perpetrator in later interactions. However, the more the women self-objectified, the more they felt ashamed (p = 0.011) and tended to punish the perpetrators less (p = 0.008). At a neural level (N = 32), objectifying interactions modulated female participants' neural signal elicited during the processing of the perpetrator, increasing early (N170) and later (EPN, LPP) ERP components. In addition, only the amplitude of the LPP positively correlated with shame (p = 0.006) and the level of self-objectification (p = 0.018). This finding provides first evidence for the specific time-course of sexual objectification, self-objectification and its associated shame response, and proves that emotional and social consequences of sexual objectification in women may depend on their tendency to self-objectify., (© 2023. The Author(s).)
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- 2023
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141. Borderline shades: Morphometric features predict borderline personality traits but not histrionic traits.
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Langerbeck M, Baggio T, Messina I, Bhat S, and Grecucci A
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- Humans, Brain diagnostic imaging, Personality, Thalamus, Phenotype, Borderline Personality Disorder diagnostic imaging
- Abstract
Borderline personality disorder (BPD) is one of the most diagnosed disorders in clinical settings. Besides the fully diagnosed disorder, borderline personality traits (BPT) are quite common in the general population. Prior studies have investigated the neural correlates of BPD but not of BPT. This paper investigates the neural correlates of BPT in a subclinical population using a supervised machine learning method known as Kernel Ridge Regression (KRR) to build predictive models. Additionally, we want to determine whether the same brain areas involved in BPD are also involved in subclinical BPT. Recent attempts to characterize the specific role of resting state-derived macro networks in BPD have highlighted the role of the default mode network. However, it is not known if this extends to the subclinical population. Finally, we wanted to test the hypothesis that the same circuitry that predicts BPT can also predict histrionic personality traits. Histrionic personality is sometimes considered a milder form of BPD, and making a differential diagnosis between the two may be difficult. For the first time KRR was applied to structural images of 135 individuals to predict BPT, based on the whole brain, on a circuit previously found to correctly classify BPD, and on the five macro-networks. At a whole brain level, results show that frontal and parietal regions, as well as the Heschl's area, the thalamus, the cingulum, and the insula, are able to predict borderline traits. BPT predictions increase when considering only the regions limited to the brain circuit derived from a study on BPD, confirming a certain overlap in brain structure between subclinical and clinical samples. Of all the five macro networks, only the DMN successfully predicts BPD, confirming previous observations on its role in the BPD. Histrionic traits could not be predicted by the BPT circuit. The results have implications for the diagnosis of BPD and a dimensional model of personality., Competing Interests: Declaration of Competing Interest Author SB was funded by the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3). The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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142. Interpersonal emotion regulation questionnaire: psychometric properties of the Italian version and associations with psychopathology.
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Messina I, Spataro P, Grecucci A, Moskow DM, Marogna C, and Hofmann SG
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The emerging field of interpersonal emotion regulation (IER) is drawing attention to forms of emotion regulation which involve communication and social interaction as part of the regulation process. The availability of instruments to measure IER in different languages represents significant promise for future work in this field. The goal of the present study was to validate an Italian adaptation of a self-report instrument for the assessment of IER, the Interpersonal Emotion Regulation Questionnaire (IERQ; Hofmann et al., 2016). In an Italian sample (N=448), exploratory and confirmatory factor analyses confirmed the original structure comprising four factors (Enhancing Positive Affect, Perspective Taking, Soothing and Social Modelling). Correlations with other measures of emotion regulation showed good convergent validity of the questionnaire.
- Published
- 2022
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