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103. What to look for with drug-induced urticaria: an accurate diagnosis is crucial. It is necessary to know which related drugs need to be avoided, as well as alternative drugs to recommend for patients

Author

Chetty, Natasha Casie and Grattan, Clive E.H.

Subjects
Urticaria -- Diagnosis, Health
Abstract

Urticaria, the second most common drug eruption after exanthematous drug eruptions, (1) is characterized by episodic short-lived swellings of the skin, oropharnyx, or genitalia. Transient leakage of plasma from small [...]

Published
2010

112. Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria : Results of the PURIST Study

Author

Schoepke, Nicole, Asero, Riccardo, Ellrich, André, Ferrer, Marta, Gimenez-Arnau, Ana, Grattan, Clive E H, Jakob, Thilo, Konstantinou, George N, Raap, Ulrike, Skov, Per Stahl, Staubach, Petra, Kromminga, Arno, Zhang, Ke, Bindslev-Jensen, Carsten, Daschner, Alvaro, Kinaciyan, Tamar, Knol, Edward F, Makris, Michael, Marrouche, Nadine, Schmid-Grendelmeier, Peter, Sussman, Gordon, Toubi, Elias, Church, Martin K, Maurer, Marcus, Schoepke, Nicole, Asero, Riccardo, Ellrich, André, Ferrer, Marta, Gimenez-Arnau, Ana, Grattan, Clive E H, Jakob, Thilo, Konstantinou, George N, Raap, Ulrike, Skov, Per Stahl, Staubach, Petra, Kromminga, Arno, Zhang, Ke, Bindslev-Jensen, Carsten, Daschner, Alvaro, Kinaciyan, Tamar, Knol, Edward F, Makris, Michael, Marrouche, Nadine, Schmid-Grendelmeier, Peter, Sussman, Gordon, Toubi, Elias, Church, Martin K, and Maurer, Marcus

Published
2019

113. Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: Results of the PURIST Study

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, CTI, Schoepke, Nicole, Asero, Riccardo, Ellrich, André, Ferrer, Marta, Gimenez-Arnau, Ana, Grattan, Clive E H, Jakob, Thilo, Konstantinou, George N, Raap, Ulrike, Skov, Per Stahl, Staubach, Petra, Kromminga, Arno, Zhang, Ke, Bindslev-Jensen, Carsten, Daschner, Alvaro, Kinaciyan, Tamar, Knol, Edward F, Makris, Michael, Marrouche, Nadine, Schmid-Grendelmeier, Peter, Sussman, Gordon, Toubi, Elias, Church, Martin K, Maurer, Marcus, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, CTI, Schoepke, Nicole, Asero, Riccardo, Ellrich, André, Ferrer, Marta, Gimenez-Arnau, Ana, Grattan, Clive E H, Jakob, Thilo, Konstantinou, George N, Raap, Ulrike, Skov, Per Stahl, Staubach, Petra, Kromminga, Arno, Zhang, Ke, Bindslev-Jensen, Carsten, Daschner, Alvaro, Kinaciyan, Tamar, Knol, Edward F, Makris, Michael, Marrouche, Nadine, Schmid-Grendelmeier, Peter, Sussman, Gordon, Toubi, Elias, Church, Martin K, and Maurer, Marcus

Published
2019

114. Long-term outcomes with subcutaneous C1-inhibitor replacement therapy for prevention of hereditary angioedema attacks

Author

Smithers, Lucy, COMPACT Investigators, Craig, Timothy, Zuraw, Bruce, Longhurst, Hilary, Cicardi, Marco, Bork, Konrad, Grattan, Clive, Katelaris, Constance, Sussman, Gordon, Keith, Paul K., Yang, William, Hébert, Jacques, Hanzlikova, Jana, Staubach-Renz, Petra, Martinez Saguer, Inmaculada, Magerl, Markus, Aygören-Pürsün, Emel, Farkas, Henriette, Reshef, Avner, Kivity, Shmuel, Neri, Sergio, Crișan, Ioana, Caballero, Teresa, Baeza, María Luisa, Hernandez, Maria Dolores, Li, Henry, Lumry, William, Bernstein, Jonathan A., Hussain, Iftikar, Anderson, John, Schwartz, Lawrence B., Jacobs, Joshua, Manning, Michael, Levy, Donald, Riedl, Marc A., Christiansen, Sandra, Feuersenger, Henrike, Pragst, Ingo, Mycroft, Sarah, Pawaskar, Dipti, Jacobs, Iris, Smithers, Lucy, COMPACT Investigators, Craig, Timothy, Zuraw, Bruce, Longhurst, Hilary, Cicardi, Marco, Bork, Konrad, Grattan, Clive, Katelaris, Constance, Sussman, Gordon, Keith, Paul K., Yang, William, Hébert, Jacques, Hanzlikova, Jana, Staubach-Renz, Petra, Martinez Saguer, Inmaculada, Magerl, Markus, Aygören-Pürsün, Emel, Farkas, Henriette, Reshef, Avner, Kivity, Shmuel, Neri, Sergio, Crișan, Ioana, Caballero, Teresa, Baeza, María Luisa, Hernandez, Maria Dolores, Li, Henry, Lumry, William, Bernstein, Jonathan A., Hussain, Iftikar, Anderson, John, Schwartz, Lawrence B., Jacobs, Joshua, Manning, Michael, Levy, Donald, Riedl, Marc A., Christiansen, Sandra, Feuersenger, Henrike, Pragst, Ingo, Mycroft, Sarah, Pawaskar, Dipti, and Jacobs, Iris

Abstract

Background: For the prevention of attacks of hereditary angioedema (HAE), the efficacy and safety of subcutaneous human C1-esterase inhibitor (C1-INH[SC]; HAEGARDA®, CSL Behring) was established in the 16-week COMPACT trial. Objective: To assess the long-term safety, occurrence of angioedema attacks, and use of rescue medication with C1-INH(SC). Methods: Open-label, randomised, parallel-arm extension of COMPACT across 11 countries. Patients with frequent angioedema attacks, either study treatment-naïve or who had completed the COMPACT trial, were randomly assigned (1:1) to 40 IU/kg or 60 IU/kg C1-INH(SC) twice per week, with conditional up-titration to optimise prophylaxis. ClinicalTrials.gov registration: NCT02316353. Results: 126 patients with a monthly attack rate of 4.3 in 3 months prior to entry in the COMPACT program were enrolled and treated for a mean of 1·5 years; 44 patients (34·9%) had >2 years exposure. Median steady-state C1-INH functional activity increased to a maximum of 73.0% with 60 IU/kg. Incidence of adverse events was low and similar in both dose groups (11·3 and 8·5 events per patient-year for 40 IU/kg and 60 IU/kg, respectively). For 40 IU/kg and 60 IU/kg, median annualised attack rates were 1·3 and 1·0, respectively and median rescue medication use was 0.2 and 0.0 times per year, respectively. Of 23 patients receiving 60 IU/kg for >2 years, 19 (83%) were attack-free during months 25–30 of treatment. Conclusion: In patients with frequent HAE attacks, long-term replacement therapy with C1-INH(SC) is safe and exhibits a substantial and sustained prophylactic effect, with the vast majority of patients becoming free from debilitating disease symptoms.

Published
2019

115. Is chronic urticaria more than skin deep?

Author

Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Grattan, Clive, School of Medicine, Department of Dermatology, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Grattan, Clive, School of Medicine, and Department of Dermatology

Abstract

Chronic urticaria is a disease characterized by the appearance of weals, angioedema or both longer than 6 weeks. Degranulation of cutaneous or submucosal mast cells leads to release of mediators including histamine resulting in redness, swelling and itch. Because mast cells are widely distributed throughout the body, the question is why they are not activated systemically or does systemic activation occur without overt end organ dysfunction? We have conducted an exploratory literature search for reports that have evidence of organ-specific dysfunction in chronic urticaria that might justify prospective observational studies. This search revealed some evidence of systemic effects of chronic urticaria in cardiac, respiratory, gastrointestinal, central nervous and musculo-skeletal systems. The relevance of these findings needs to be further determined. However, they justify prospective studies in larger numbers of patients and at different stages of disease activity., NA

Published
2019

122. Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria

Author

Hide, Michihiro, Francis, David M., Grattan, Clive E.H., Hakimi, John, Kochan, Jarema P., and Greaves, Malcolm W.

Subjects
Autoantibodies -- Physiological aspects, Urticaria -- Physiological aspects, Histamine -- Physiological aspects, Immunoglobulin G -- Physiological aspects
Abstract

Autoantibodies against the alpha subunit of the high affinity immunoglobulin E (IgE) receptor may cause histamine release in patients with chronic urticaria. Chronic urticaria is a skin disorder characterized by recurrent, itchy lesions. Histamine is a substance that functions as a mediator of hypersensitivity, or an exaggerated immune response. A study examined histamine release in four patients with chronic urticaria of unknown cause. Autoantibodies against the alpha subunit of the high affinity IgE receptor were found in the peripheral blood of all four patients. Histamine release was induced by purified immunoglobulin G (IgG) from all four patients' blood. The purified IgG reacted almost completely with the alpha subunit of the high affinity IgE receptor. The antibodies against the alpha subunit may be histamine-releasing IgG autoantibodies.

Published
1993

123. Reviewer acknowledgement 2012

Author

Grattan Clive

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Contributing reviewers The editors of Clinical and Translational Allergy would like to thank all of our reviewers who have contributed to the journal in Volume 2 (2012).

Published
2013
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124. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

Papadopoulos Nikolaos G, Agache Ioana, Bavbek Sevim, Bilo Beatrice M, Braido Fulvio, Cardona Victoria, Custovic Adnan, deMonchy Jan, Demoly Pascal, Eigenmann Philippe, Gayraud Jacques, Grattan Clive, Heffler Enrico, Hellings Peter W, Jutel Marek, Knol Edward, Lötvall Jan, Muraro Antonella, Poulsen Lars K, Roberts Graham, Schmid-Grendelmeier Peter, Skevaki Chrysanthi, Triggiani Massimo, vanRee Ronald, Werfel Thomas, Flood Breda, Palkonen Susanna, Savli Roberta, Allegri Pia, Annesi-Maesano Isabella, Annunziato Francesco, Antolin-Amerigo Dario, Apfelbacher Christian, Blanca Miguel, Bogacka Ewa, Bonadonna Patrizia, Bonini Matteo, Boyman Onur, Brockow Knut, Burney Peter, Buters Jeroen, Butiene Indre, Calderon Moises, Cardell Lars, Caubet Jean-Christoph, Celenk Sevcan, Cichocka-Jarosz Ewa, Cingi Cemal, Couto Mariana, deJong Nicolette, Del Giacco Stefano, Douladiris Nikolaos, Fassio Filippo, Fauquert Jean-Luc, Fernandez Javier, Rivas Montserrat, Ferrer Marta, Flohr Carsten, Gardner James, Genuneit Jon, Gevaert Philippe, Groblewska Anna, Hamelmann Eckard, Hoffmann Hans, Hoffmann-Sommergruber Karin, Hovhannisyan Lilit, Hox Valérie, Jahnsen Frode L, Kalayci Ömer, Kalpaklioglu Ayse, Kleine-Tebbe Jörg, Konstantinou George, Kurowski Marcin, Lau Susanne, Lauener Roger, Lauerma Antti, Logan Kirsty, Magnan Antoine, Makowska Joanna, Makrinioti Heidi, Mangina Paraskevi, Manole Felicia, Mari Adriano, Mazon Angel, Mills Clare, Mingomataj ErvinÇ, Niggemann Bodo, Nilsson Gunnar, Ollert Markus, O'Mahony Liam, O'Neil Serena, Pala Gianni, Papi Alberto, Passalacqua Gianni, Perkin Michael, Pfaar Oliver, Pitsios Constantinos, Quirce Santiago, Raap Ulrike, Raulf-Heimsoth Monika, Rhyner Claudio, Robson-Ansley Paula, Alves Rodrigo, Roje Zeljka, Rondon Carmen, Rudzeviciene Odilija, Ruëff Franziska, Rukhadze Maia, Rumi Gabriele, Sackesen Cansin, Santos Alexandra F, Santucci Annalisa, Scharf Christian, Schmidt-Weber Carsten, Schnyder Benno, Schwarze Jürgen, Senna Gianenrico, Sergejeva Svetlana, Seys Sven, Siracusa Andrea, Skypala Isabel, Sokolowska Milena, Spertini Francois, Spiewak Radoslaw, Sprikkelman Aline, Sturm Gunter, Swoboda Ines, Terreehorst Ingrid, Toskala Elina, Traidl-Hoffmann Claudia, Venter Carina, Vlieg-Boerstra Berber, Whitacker Paul, Worm Margitta, Xepapadaki Paraskevi, and Akdis Cezmi A

Subjects
Allergy, Allergic diseases, Policy, Research needs, Research funding, Europe, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Published
2012
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125. A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria

Author

Iqbal Kamran, Bhargava Kapil, Skov Per, Falkencrone Sidsel, and Grattan Clive EH

Subjects
Ciclosporin, Chronic urticaria, Basophil histamine release assay, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically (P

Published
2012
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126. List of Contributors

Author

Abdullah, Anthony, Abel, Mary Kathryn, Abudu, Boya, Abu-Hilal, Mohannad, Al Hammadi, Anwar, Al Awadhi, Ameen, Alexis, Andrew F., Aljefri, Khadija, Al-Kutubi, Huda, Almazan, Timothy H., Almohssen, Amer Ali, Alpsoy, Erkan, Ameen, Mahreen, Anderson, Bryan E., Anshelevich, Ellen, Bacik, Lindsay C., Baker, Donald J., Banach, David, Banfield, Cedric C., Baran, Robert, Barankin, Benjamin, Barkham, Melissa C., Bauer, Johann W., Begun, Zoe, Bell, Michael A., Benton, Emma, Bergfeld, Wilma F., Berman, Brian, Berth-Jones, John, Bhate, Chinmoy, Bhatia, Bhavnit K., Bilgiç, Asli, Bitterman, Avi, Black, Samantha, Blume, Jonathan E., Bohelay, Gérôme, Bordet, Nevianna, Brodell, Robert T., Brown, Marc D., Brownstone, Nicholas D., Burdick, Anne E., Butala, Niraj, Callen, Jeffrey P., Camacho, Ivan D., Camasmie, Helena, Caplivski, Daniel, Cappell, Mitchell S., Casey, Genevieve A., Caux, Frédéric, Chan, Cynthia X., Chan, Lawrence S., Chan, Loi-Yuen, Chan, Stephanie, Chao, Kevin Young, Chen, Jennifer K., Child, Fiona J., Choate, Keith, Chosidow, Olivier, Chousakos, Emmanouil, Chuh, Antonio A.T., Cices, Ahuva, Cobos, Gabriela A., Cohen, Steven R., Collier, Nicholas, Cooper, Elizabeth A., Coulson, Ian H., Cowen, Edward W., Craiglow, Brittany, Cruz, Ponciano D., Jr., Cummins, Donna, Cusack, Carrie Ann R., Daniel, Benjamin S., Daunton, Adam R.A., Davis, Mark D.P., Dawe, Robert S., D’Cruz, David P., de Berker, David, de Brito, Marianne, De Maeseneer, Hannelore, de Moll, Ellen H., Decker, Ashley, DeHoratius, Danielle M., Del Rosso, James Q., Desai, Seemal R., Dhawan, Gaurav K., DiGiovanna, John J., Dodiuk-Gad, Roni P., Duffy, Robert F., Dummer, Reinhard, Dunn, Annie, Duong, Tu-Anh, Dutz, Jan P., Eichenfield, Dawn Z., Eichenfield, Lawrence F., Eisen, Drore, Elman, Scott A., Elston, Dirk M., Elyoussfi, Sarah, Emanuel, Patrick O.M., Enos, Clinton W., Noliza Encarnacion, Maria Rosa, Epstein, Ervin H., Jr., Farberg, Aaron S., Farrugia, Michael E., Fassihi, Hiva, Fawaz, Bilal, Feigenbaum, Lawrence S., Felmingham, Claire, Femia, Alisa, Fenner, Justine, Ferguson, Felicity, Fett, Nicole, Finlay, Andrew Y., Firooz, Alireza, Firoz, Bahar F., Flischel, Amy E., Forrestel, Amy, Foley, Kelly A., Fourzali, Kayla, Frare, Cindy P., Freedman, Derek, Frey, Surina, Fried, Richard, Friedman, Adam J., Fuller, L. Claire, Gabel, Colleen, Gach, Joanna E., Ganesh, Jaya, Ganjoo, Shikhar, Gao, Jing Mia, Gaspari, Anthony A., Glaser, Katherine, Goenaga-Vázquez, Yamila, Goldberg, Leonard H., Goldfarb, Johanna, González Barreto, Reina M., Goon, Peter K.C., Gottlieb, Alice B., Gowda, Asha, Grada, Ayman A., Grande, Donald J., Grant, Matthew, Grattan, Clive E.H., Green, Justin J., Grimes, Pearl E., Gropper, Charles A., Grossberg, Anna L., Gupta, Aditya K., Guttman-Yassky, Emma, Guzman, Anthony K., Haddadi, Nazgol-Sadat, Hadi, Ali S., Hadi, Suhail M., Hagans, Iris A., Hairston, Bethany R., Halpern, Analisa Vincent, Halverstam, Caroline, Haque, Emily, Harries, Matthew, Harris, John E., Haw, William, Hazan, Ezra, Heaton, Henry, Hebert, Adelaide A., Helm, Matthew F., Helms, Stephen E., Hexsel, Camille L., Hexsel, Doris M., Heymann, Warren R., High, Whitney A., Hoffman, Melissa, Horenstein, Marcelo G., Hurst, Eva A., Hussain, Walayat, Ibbotson, Sally H., Ibrahim, Sherrif F., Inamadar, Arun C., Ingen-Housz-Oro, Saskia, Iorizzo, Matilde, Jacobe, Heidi, James, William D., Jemec, Gregor B.E., Jennings, Tara, Jibbe, Atieh S., Johnston, Graham A., Joly, Pascal, Joseph, Adrienne, Kanelleas, Antonios, Karadağ, Ayşe Serap, Katugampola, Ruwani P., Katz, Bruce E., Kavanagh, Gina M., Khan, Sidra S., Khattri, Saakshi, Khong, Brendan, Khorasani, Hooman, Kim, Ellen J., Kim, Hee J., Kim, Youn H., King, Brett, Kirby, Joslyn S., Kirby, Lisa, Kirsner, Robert S., Ko, Lauren, Koch, Dimitra, Koh, Wei-Liang, Koo, John Y.M., Kopp, Sandra A., Kouby, Floriane, Kovarik, Carrie, Kraemer, Kenneth H., Kreeshan, Firas C., Krishnamurthy, Karthik, Kroshinsky, Daniela, Krueger, Steven, Kvernebo, Knut, Laimer, Martin, Lalor, Leah, Lam, Charlene, Lambert, Peter C., Lang, Claudia, Lawlor, Frances, Lawrence, Naomi, Layher, Heather, Lebwohl, Mark G., Lebwohl, Oscar, Lee, Helen, Lehman, Julia S., Lemieux, Alexandre, Leslie, Tabi A., Leung, Alexander K.C., Levitt, Jacob O., Lewis, Daniel J., Lewis, Fiona M., Liaqat, Maryam, Ling, Tsui Chin, Litchman, Graham H., Liu, Stephanie, Luger, Thomas A., Luna, Paula C., Lupi, Omar, Lyon, Calum C., Maatouk, Ismael, MacGibeny, Margaret A., Maddukuri, Spandana, Mahmoud, Bassel H., Makkar, Timothy, Mallett, Richard B., Malta, Kiana, Manci, Rachel, Mancuso, Jennifer, Manders, Steven, Mann, Jasmine, Marghoob, Ashfaq A., Markova, Alina, Markowitz, Orit, Martinez, Daniela, Martinka, Michal, Maurer, Marcus, McGee, Jean S., McLarney, R. Matthew, Meah, Nekma, Metz, Martin, Micali, Giuseppe, Michalik, Daniel, Micheletti, Robert G., Mirowski, Ginat W., Mori, Shoko, Mørk, Cato, Morris, Caroline R., Morton, Colin A., Motaparthi, Kiran, Muldoon, Eavan G., Murase, Jenny E., Murdoch, Michele E., Murrell, Dedee F., Muthiah, Shareen, Myers, Bridget, Naeem, Zunaira, Nakamura, Mio, Nambi, Rabindranath, Nasca, Maria R., Navarrete-Dechent, Cristian, Needham, Glen R., Nehal, Kishwer, Newell, Glenn C., Nixon, Rosemary L., Noy, Mariana L., Nunns, David, Olbricht, Suzanne M., Oldenburg, Reid, Orekoya, Fikki, Osborne, Ruth A., Owen, Cindy E., Pandya, Amit G., Papaefthymiou, Vasileios, Paravar, Taraneh, Parish, Jennifer L., Parish, Lawrence Charles, Perz, Allison M., Peterson, Danielle, Phelps, Robert G., Philips, Rebecca C., Phillips, Tania J., Poh-Fitzpatrick, Maureen B., Polansky, Maxim, Pomeranz, Miriam Keltz, Pope, Elena, Privalle, Ashley N., Prost, Catherine, Que, Syril Keena T., Quint, Koen, Qureshi, Sumera, Rashid, Rabia S., Rashighi, Mehdi, Ratnavel, Ravi, Rawi, Sarah, Reddy, Vidhatha, Renzi, Michael A., Jr., Revuz, Jean, Richard, Gabriele, Rigel, Darrell S., Rivera, Sydney, Robles, Wanda S., Rodriguez, Ramiro, Jr., Rook, Alain H., Rosen, Ted, Rosenbach, Misha, Rowland, Emma, Rustin, Malcolm, Sadlier, Muriel, Salavastru, Carmen Maria, Samimi, Sara, Sandoval, Erika Romero, Sarkany, Robert P.E., Scerri, Lawrence, Schimmel, Joshua, Schmults, Chrysalyne D., Schnur, Rhonda E., Schoinas, Spyridon, Schwartz, Robert A., Scorer, Matthew J., Shah, Kalee, Shah, Nidhi, Shah, Radhika, Shah, Sheevam, Sharif, Jennifer, Shea, Christopher R., Shear, Neil H., Sheriff, Tabrez, Shields, Bridget E., Shimizu, Hiroshi, Shinkai, Kanade, Shiu, Jessica, Shivanna, Ragunatha, Shwayder, Tor, Silverberg, Nanette, Sinclair, Rodney, Singal, Archana, Smith, Janellen, Snyder, Margaret L., Sommer, Lacy L., Soter, Nicholas A., Stanger, Roselyn K., Stoll, Joseph R., Sun, Qisi, Sunderkötter, Cord, Swali, Ritu, Taibjee, Saleem M., Talasila, Sreya, Talebi-Liasi, Faezeh, Tamura, Deborah, Tan, Eunice, Y.-M. Tang, William, Thibodeaux, Quinn, Tian, Tina M., Tiplica, George Sorin, Tkachenko, Elizabeth, Tolkachjov, Stanislav N., Tolliver, Starling D., Tomecki, Kenneth, Torgerson, Rochelle R., Tosti, Antonella, Tsuji-Abe, Yukiko, Twaij, Sara, Tyring, Stephen K., van de Kerkhof, Peter, Van Gysel, Dirk, Van Voorhees, Abby S., Varma, Aakaash, Vasani, Resham, Verma, Shyam B., Vermeer, Maarten H., Vieira, Carlos, Vignes, Stéphane, Vleugels, Ruth Ann, Wallengren, Joanna, Wanat, Karolyn A., Wang, Erica B., Wei, Chapman, Weichert, Gabriele, Weigelt, Maximillian A., Weinberg, Jeffrey M., Weitzer, Danielle, Welponer, Tobias, Werth, Victoria P., White, Lucile E., Wilkin, Jonathan K., Wilson, Niall, Wiznia, Lauren E., Wollenberg, Andreas, Wollina, Uwe, Chun Wong, Junie Li, Wright, Andrew L., Wynne, Matthew, Yan, Daisy, Yosipovitch, Gil, Youssef, Molly J., Zaenglein, Andrea L., Zaki, Irshad, Zarbo, Allison, Zawar, Vijay, Zhu, Jane L., Zone, John J., and Zuberbier, Torsten

Published
2022
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127. Neues Rahmenwerk zur Interpretation von IgE-Tests — eine wissenschaftliche Zusammenfassung

Author

Roberts, Graham, Graessel, Anke, Ollert, Markus, Aalberse, Rob, Austin, Moira, Cardona, Victoria, Custovic, Adnan, Dunngalvin, Audrey, Eigenmann, Philippe A., Fassio, Filippo, Grattan, Clive, Hellings, Peter, Hourihane, Jonathan, Knol, Edward, Muraro, Antonella, Papadopoulos, Nikolaos, Santos, Alexandra F., Schnadt, Sabine, and Tzeli, Kassiani

Abstract

Seit vielen Jahren setzen Allergologen auf IgE-Tests wie Hautpricktests und die Messung der spezifischen IgE-Antikörper im Serum gegen das vollständige Allergen, um IgE-vermittelte, klinisch relevante Allergien zu diagnostizieren. Diese Tests haben einen wesentlichen Nachteil: Sie stellen zwar eine Sensibilisierung fest, diese hängt aber nur indirekt mit der klinisch relevanten Allergie zusammen. Mit vielen Patienten müssen daher Provokationstests durchgeführt werden, die häufig teuer und mit potenziell schwerwiegenden Reaktionen verbunden sind, um eine endgültige Diagnose zu stellen.Die Wahrscheinlichkeit für eine klinisch relevante Allergie kann durch die Ergebnisse eines IgE-Tests semi-quantitativ bestimmt werden. Wie belastbar diese Korrelation ist, variiert je nach Alter, ethnischer Herkunft und Art der vermeintlich allergischen Reaktion des Patienten, und wird durch den Grad der Pollenexposition, die Ernährung sowie bestehende klinische Erkrankungen, etwa Ekzeme, beeinflusst. Werden diese individuellen Faktoren bei der Auswertung eines IgE-Tests berücksichtigt, kann die Wahrscheinlichkeit für das Auftreten einer klinisch relevanten Allergie präziser abgeschätzt werden (Prätestwahrscheinlichkeit). Beruhend auf den Testergebnissen weist dann das Vorhandensein jeder dieser patientenspezifischen Charakteristika darauf hin, ob bei einem Patienten mit höherer oder geringerer Wahrscheinlichkeit eine klinisch relevante Allergie vorliegt (Posttestwahrscheinlichkeit). Die Einbeziehung von Ko-Faktoren, wie zum Beispiel sportliche Betätigung, könnten auch erforderlich sein, um sensitivere und genauere Testresultate zu erzielen.In dieser Arbeit werden zwei Ansätze vorgestellt, wie Prätestwahrscheinlichkeiten bei der Interpretation der IgE-Testergebnisse eingebunden werden können. Obwohl diese erhebliche Vorteile bieten, speziell in der Klinik, muss noch mehr in diesen Forschungsbereich investiert werden, um künftig die Prätestwahrscheinlichkeiten für verschiedene Bedingungen, Lebensregionen und Allergene ableiten zu können. Ebenfalls muss noch genauer geklärt werden, welchen Stellenwert die Testergebnisse in den verschiedenen Populationen haben. Kliniker müssen dafür sorgen, dass die Patienten die Testergebnisse klar verstehen, um ihnen Selbstvertrauen zum Selbstmanagement zu geben.

Published
2018

128. New Framework for the Interpretation of IgE Tests - A scientific Summary

Author

Roberts, Graham Graessel, Anke Ollert, Markus Aalberse, Rob and Austin, Moira Cardona, Victoria Custovic, Adnan and Dunngalvin, Audrey Eigenmann, Philippe A. Fassio, Filippo and Grattan, Clive Hellings, Peter Hourihane, Jonathan Knol, Edward Muraro, Antonella Papadopoulos, Nikolaos Santos, Alexandra F. Schnadt, Sabine Tzeli, Kassiani

Published
2018

129. EAACI/GA2LEN/EDF/WAO-Leitlinie für die Definition, Klassifikation, Diagnose und das Management der Urtikaria — konsentierte, deutschsprachige Übersetzung

Author

Zuberbier, Torsten, Aberer, Werner, Asero, Riccardo, Latiff, Amir Hamzah Abdul, Baker, Diane, Ballmer-Weber, Barbara K, Bernstein, Jonathan A, Bindslev-Jensen, Carsten, Brzoza, Zenon, Bedrikow, Roberta Buense, Canonica, Giorgio Walter, Church, Martin K, Craig, Timothy, Danilycheva, Inna Vladimirovna, Dressler, Corinna, Ensina, Luis Felipe, Giménez-Arnau, Ana M, Godse, Kiran, Gonçalo, Margarida, E. H. Grattan, Clive, Hebert, Jacques, Hide, Michihiro, Kaplan, Allen, Kapp, Alexander, Katelaris, Constance H., Kocatürk, Emek, Kulthanan, Kanokvalai, Larenas-Linnemann, Desiree, Leslie, Tabi A., Magerl, Markus, Mathelier-Fusade, Pascale, Meshkova, Raisa Y., Metz, Martin, Nast, Alexander, Nettis, Eustachio, Oude-Elberink, Hanneke N G, Rosumeck, Stefanie, Saini, Sarbjit S, Sánchez-Borges, Mario, Schmid-Grendelmeier, Peter, Staubach, Petra, Sussman, Gordon, Toubi, Elias, Vena, Gino A., Vestergaard, Christian, Wedi, Bettina, Werner, Ricardo N., Zhao, Zuotao, Maurer, Marcus, Brehler, Randolf, Brockow, Knut, Fluhr, Joachim, Grabbe, Jürgen, Hamelmann, Eckard, Hartmann, Karin, Jakob, Thilo, Merk, Hans, Ollert, Markus, Ott, Hagen, Reese, Imke, Ruëff, Franziska, and Werfel, Thomas

Published
2018

130. UK Single Institution Experience of Mastocytosis: Guy's and St Thomas' NHS Foundation Trust

Author

Oni, Clare, primary, Moonim, Mufaddal, additional, Desterro, Joana, additional, Grattan, Clive, additional, Curto-Garcia, Natalia, additional, Woodley, Claire, additional, Ciesielska, Monika, additional, Drasutyte, Deimante, additional, Francis, Yvonne, additional, O'Sullivan, Jennifer, additional, Olaoni, Thompson, additional, Green, Anna, additional, Yurina, Miki, additional, Ong, Mark, additional, Cross, Nick C.P., additional, McLornan, Donal P., additional, and Radia, Deepti, additional

Published
2019
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132. Ligelizumab for Chronic Spontaneous Urticaria

Author

Maurer, Marcus, primary, Giménez-Arnau, Ana M., additional, Sussman, Gordon, additional, Metz, Martin, additional, Baker, Diane R., additional, Bauer, Andrea, additional, Bernstein, Jonathan A., additional, Brehler, Randolf, additional, Chu, Chia-Yu, additional, Chung, Wen-Hung, additional, Danilycheva, Inna, additional, Grattan, Clive, additional, Hébert, Jacques, additional, Katelaris, Constance, additional, Makris, Michael, additional, Meshkova, Raisa, additional, Savic, Sinisa, additional, Sinclair, Rodney, additional, Sitz, Karl, additional, Staubach, Petra, additional, Wedi, Bettina, additional, Löffler, Jürgen, additional, Barve, Avantika, additional, Kobayashi, Kenneth, additional, Hua, Eva, additional, Severin, Thomas, additional, and Janocha, Reinhold, additional

Published
2019
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133. Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: Results of the PURIST Study

Author

Schoepke, Nicole, primary, Asero, Riccardo, additional, Ellrich, André, additional, Ferrer, Marta, additional, Gimenez‐Arnau, Ana, additional, E. H. Grattan, Clive, additional, Jakob, Thilo, additional, Konstantinou, George N., additional, Raap, Ulrike, additional, Skov, Per Stahl, additional, Staubach, Petra, additional, Kromminga, Arno, additional, Zhang, Ke, additional, Bindslev‐Jensen, Carsten, additional, Daschner, Alvaro, additional, Kinaciyan, Tamar, additional, Knol, Edward F., additional, Makris, Michael, additional, Marrouche, Nadine, additional, Schmid‐Grendelmeier, Peter, additional, Sussman, Gordon, additional, Toubi, Elias, additional, Church, Martin K., additional, and Maurer, Marcus, additional

Published
2019
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134. EAACI/GA2LEN/EDF/WAO-Leitlinie für die Definition, Klassifikation, Diagnose und das Management der Urtikaria — konsentierte, deutschsprachige Übersetzung

Author

Zuberbier, Torsten, primary, Aberer, Werner, additional, Asero, Riccardo, additional, Latiff, Amir Hamzah Abdul, additional, Baker, Diane, additional, Ballmer-Weber, Barbara, additional, Bernstein, Jonathan A., additional, Bindslev-Jensen, Carsten, additional, Brzoza, Zenon, additional, Bedrikow, Roberta Buense, additional, Canonica, Giorgio Walter, additional, Church, Martin K., additional, Craig, Timothy, additional, Danilycheva, Inna Vladimirovna, additional, Dressler, Corinna, additional, Ensina, Luis Felipe, additional, Giménez-Arnau, Ana, additional, Godse, Kiran, additional, Goncalo, Margarida, additional, Grattan, Clive, additional, Hebert, Jacques, additional, Hide, Michihiro, additional, Kaplan, Allen, additional, Kapp, Alexander, additional, Katelaris, Constance H., additional, Kocatürk, Emek, additional, Kulthanan, Kanokvalai, additional, Larenas-Linnemann, Désirée, additional, Leslie, Tabi A., additional, Magerl, Markus, additional, Mathelier-Fusade, Pascale, additional, Meshkova, Raisa Y., additional, Metz, Martin, additional, Nast, Alexander, additional, Nettis, Eustachio, additional, Oude-Elberink, Hanneke, additional, Rosumeck, Stefanie, additional, Saini, Sarbjit S., additional, Sánchez-Borges, Mario, additional, Schmid-Grendelmeier, Peter, additional, Staubach, Petra, additional, Sussman, Gordon, additional, Toubi, Elias, additional, Vena, Gino A., additional, Vestergaard, Christian, additional, Wedi, Bettina, additional, Werner, Ricardo N., additional, Zhao, Zuotao, additional, Maurer, Marcus, additional, Brehler, Randolf, additional, Brockow, Knut, additional, Fluhr, Joachim, additional, Grabbe, Jürgen, additional, Hamelmann, Eckard, additional, Hartmann, Karin, additional, Jakob, Thilo, additional, Merk, Hans, additional, Ollert, Markus, additional, Ott, Hagen, additional, Reese, Imke, additional, Rueff, Franziska, additional, and Werfel, Thomas, additional

Published
2018
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137. Angioedema in Chronic Spontaneous Urticaria Is Underdiagnosed and Has a Substantial Impact : Analyses From ASSURE-CSU

Author

Sussman, Gordon, Abuzakouk, Mohamed, Bérard, Frédéric, Canonica, Walter, Oude Elberink, Hanneke, Giménez-Arnau, Ana, Grattan, Clive, Hollis, Kelly, Hunter, Shannon, Knulst, André, Lacour, Jean-Philippe, Lynde, Charles, Marsland, Alexander, McBride, Doreen, Maurer, Marcus, Nakonechna, Alla, Ortiz de Frutos, Javier, Reynolds, Maria, Sweeney, Carolyn, Tian, Haijun, Weller, Karsten, Wolin, Daniel, Balp, Maria-Magdalena, Sussman, Gordon, Abuzakouk, Mohamed, Bérard, Frédéric, Canonica, Walter, Oude Elberink, Hanneke, Giménez-Arnau, Ana, Grattan, Clive, Hollis, Kelly, Hunter, Shannon, Knulst, André, Lacour, Jean-Philippe, Lynde, Charles, Marsland, Alexander, McBride, Doreen, Maurer, Marcus, Nakonechna, Alla, Ortiz de Frutos, Javier, Reynolds, Maria, Sweeney, Carolyn, Tian, Haijun, Weller, Karsten, Wolin, Daniel, and Balp, Maria-Magdalena

Published
2018

138. Angioedema in Chronic Spontaneous Urticaria Is Underdiagnosed and Has a Substantial Impact: Analyses From ASSURE-CSU

Author

MS Dermatologie/Allergologie, Infection & Immunity, Sussman, Gordon, Abuzakouk, Mohamed, Bérard, Frédéric, Canonica, Walter, Oude Elberink, Hanneke, Giménez-Arnau, Ana, Grattan, Clive, Hollis, Kelly, Hunter, Shannon, Knulst, André, Lacour, Jean-Philippe, Lynde, Charles, Marsland, Alexander, McBride, Doreen, Maurer, Marcus, Nakonechna, Alla, Ortiz de Frutos, Javier, Reynolds, Maria, Sweeney, Carolyn, Tian, Haijun, Weller, Karsten, Wolin, Daniel, Balp, Maria-Magdalena, MS Dermatologie/Allergologie, Infection & Immunity, Sussman, Gordon, Abuzakouk, Mohamed, Bérard, Frédéric, Canonica, Walter, Oude Elberink, Hanneke, Giménez-Arnau, Ana, Grattan, Clive, Hollis, Kelly, Hunter, Shannon, Knulst, André, Lacour, Jean-Philippe, Lynde, Charles, Marsland, Alexander, McBride, Doreen, Maurer, Marcus, Nakonechna, Alla, Ortiz de Frutos, Javier, Reynolds, Maria, Sweeney, Carolyn, Tian, Haijun, Weller, Karsten, Wolin, Daniel, and Balp, Maria-Magdalena

Published
2018

142. Neues Rahmenwerk zur Interpretation von IgE-Tests — eine wissenschaftliche Zusammenfassung

Author

Roberts, Graham, primary, Graessel, Anke, additional, Ollert, Markus, additional, Aalberse, Rob, additional, Austin, Moira, additional, Cardona, Victoria, additional, Custovic, Adnan, additional, DunnGalvin, Audrey, additional, Eigenmann, Philippe A., additional, Fassio, Filippo, additional, Grattan, Clive, additional, Hellings, Peter, additional, Hourihane, Jonathan, additional, Knol, Edward, additional, Muraro, Antonella, additional, Papadopoulos, Nikolaos, additional, Santos, Alexandra F., additional, Schnadt, Sabine, additional, and Tzeli, Kassiani, additional

Published
2018
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143. Long-Term Outcomes with Subcutaneous C1-Inhibitor Replacement Therapy for Prevention of Hereditary Angioedema Attacks: An Open-Label Extension Study of the COMPACT Trial

Author

Craig, Timothy, primary, Zuraw, Bruce, additional, Longhurst, Hilary, additional, Cicardi, Marco, additional, Bork, Konrad, additional, Grattan, Clive, additional, Katelaris, Constance, additional, Sussman, Gordon, additional, Keith, Paul K., additional, Yang, William, additional, Hébert, Jacques, additional, Hanzlikova, Jana, additional, Staubach-Renz, Petra, additional, Martinez-Saguer, Inmaculada, additional, Magerl, Markus, additional, Aygören-Pürsün, Emel, additional, Farkas, Henriette, additional, Reshef, Avner, additional, Kivity, Shmuel, additional, Neri, Sergio, additional, Crisan, Ioana, additional, Caballero, Teresa, additional, Baeza, Maria L., additional, Hernandez, Maria Dolores, additional, Li, Henry, additional, Lumry, William, additional, Bernstein, Jonathan A., additional, Hussain, Iftikar, additional, Anderson, John, additional, Schwartz, Lawrence B., additional, Jacobs, Joshua, additional, Manning, Michael, additional, Levy, Donald, additional, Riedl, Marc, additional, Christiansen, Sandra, additional, Feuersenger, Henrike, additional, Pragst, Ingo, additional, Mycroft, Sarah, additional, Pawaskar, Dipti, additional, Jacobs, Iris, additional, and Investigators, COMPACT, additional

Published
2018
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147. Colaboradores

Author

Sarah Abraham, Roshini, Albanesi, Cristina, Alevizos, Ilias, Anguita, Juan, Antiochos, Brendan, Aranow, Cynthia, Atkinson, John P., Austin, Howard A., III, Babu, Subash, Ballow, Mark C., Balow, James E., Belmont, John W., Berek, Claudia, Beukelman, Timothy, Bhavsar, Tapan, Andrew Bird, J., Blutt, Sarah E., Boguniewicz, Mark, Bonamichi-Santos, Rafael, Boisson, Bertrand, Borzova, Elena, Boyaka, Prosper N., Boyce, Joshua, Browne, Sarah K., Burks, Wesley, Bustamante, Jacinta, Calder, Virginia L., Campbell, Matthew, Cardones, Adela Rambi G., Casanova, Jean-Laurent, Castells, Mariana, Cavacini, Lisa A., Chan, Edwin S.L., Chaplin, David D., Winn Chatham, W., Chen, Edward S., Chinen, Javier, Christopher-Stine, Lisa, Ciancanelli, Michael, Cope, Andrew P., Corry, David B., Crea, Filippo, Cron, Randy Q., Cuellar-Rodriguez, Jennifer M., Dalakas, Marinos C., Dann, Sara M., Diamond, Betty, Du Clos, Terry W., Dupuis-Boisson, Stéphanie, Eagar, Todd N., Elmets, Craig A., Erkan, Doruk, Fanning, Laura, Fikrig, Erol, Flego, Davide, Fleisher, Thomas A., Fonacier, Luz, Fontenot, Andrew P., Freeman, Alexandra F., Frew, Anthony J., Fujihashi, Kohtaro, Gadina, Massimo, Gatt, Moshe E., Eric Gershwin, M., Gillespie, Susan L., Goronzy, Jörg J., Goswami, Sangeeta, Grattan, Clive E.H., Greenspan, Neil S., Gupta, Sarthak, Gustafson, Claire E., Hall, Russell P., III, Hamilton, Robert G., Harrington, Laurie E., Harrison, Leonard C., Hasni, Sarfaraz A., Helbling, Arthur, Hester, Joanna, Holland, Steven M., Hourcade, Dennis, Huntington, Nicholas D., Hwangpo, Tracy, Imboden, John B., Issa, Fadi, Izraeli, Shai, Jaffe, Elaine S., Jalkanen, Sirpa, Jones, Stacie, Jouanguy, Emmanuelle, Kabbani, Sarah, Kaufmann, Stefan H.E., Kheradmand, Farrah, Kohn, Donald B., Korngold, Robert, Kovalszki, Anna, Kuhns, Douglas B., Kulkarni, Hrishikesh, Kuo, Caroline Y., Lahouti, Arash, Ola Landgren, C., Laurence, Arian, Lee, Joyce S., Lemière, Catherine, Leung, Donald Y.M., Levinson, Arnold I., Levy, Ofer, Lewis, Dorothy E., Lin, Phoebe, Linkermann, Andreas, Liuzzo, Giovanna, Lockshin, Michael D., Lord, Allison K., Lozier, Jay N., Luong, Amber, Luqmani, Raashid, Mackay, Meggan, Maltzman, Jonathan S., Mannon, Peter J., Manns, Michael P., Martin, James G., Maynard, Craig L., McCash, Samual, McDonald, Douglas R., Melby, Peter C., Miller, Stephen D., Mitchell, Anna L., Mohd-Zaki, Amirah, Mold, Carolyn, Moller, David R., Monos, Dimitrios S., Mueller, Scott N., Mulders-Manders, Catharina M., Mulligan, Mark J., Müller, Ulrich R., Munshi, Pashna N., Murata, Kazunori, Murphy, Philip M., Navasa, Nicolás, Noel, Pierre, Notarangelo, Luigi D., Nussbaum, Robert L., Nutman, Thomas B., Nutt, Stephen L., Oliveira, João B., Ortel, Thomas L., O’Shea, John J., Pai, Sung-Yun, Pandit, Lavannya, Paul, Mary E., Pearce, Simon H.S., Pedicino, Daniela, Peterson, Erik J., Picard, Capucine, Pittaluga, Stefania, Long Priel, Debra, Puck, Jennifer, Puel, Anne, Radbruch, Andreas, Reece, Stephen T., Reveille, John D., Rich, Robert R., Roifman, Chaim M., Rosen, Antony, Rosenbaum, James T., Rosenzweig, Sergio D., Rouse, Barry T., Rowley, Scott D., Sakaguchi., Shimon, Salmi, Marko, Sant, Andrea J., Satola, Sarah W., Saw, Valerie, Schechter, Marcos C., Schroeder, Harry W., Segal, Benjamin M., Selmi, Carlo, Shankar, Sushma, Sharma, Anu, Sharma, Padmanee, Shearer, William T., Siegel, Richard M., Simon, Anna, Smith, Gideon P., Stephens, David S., Stephens, Robin, Straumann, Alex, Teos, Leyla Y., Timares, Laura, Tonnus, Wulf, Torres, Raul M., Uzel, Gülbü, van der Hilst, Jeroen C.H., van der Meer, Jos W.M., Varga, John, Vyas, Jatin M., Waldman, Meryl, Weiser, Peter, Weller, Peter F., Weyand, Cornelia M., Wigley, Fredrick M., Winchester, Robert J., Wing, James B., Wood, Kathryn J., Wu, Xiaobo, Xu, Hui, Yee, Cassian, and Zhang, Shen-Ying

Published
2020
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148. 7th drug hypersensitivity meeting: part one

Author

Carr, Daniel F., Chung, Wen-Hung, Jenkiins, Rosalind E., Chaponda, Mas, Nwikue, Gospel, Cornejo Castro, Elena M., Antoine, Daniel J., Pirmohamed, Munir, Wuillemin, Natascha, Dina, Dolores, Eriksson, Klara K., Yerly, Daniel, Pavlos, Rebecca, Mckinnin, Elizabeth, Ostrov, David, Peters, Bjoern, Buus, Soren, Koelle, David, Chopra, Abha, Rive, Craig, Redwood, Alec, Restrepo, Susana, Bracey, Austin, Yuan, Jing, Gaudieri, Silvana, Carrington, Mary, Haas, David, Mallal, Simon, Phillips, Elizabeth, De Boer, Douwe, Menheere, Paul, Nieuwhof, Chris, Bons, Judith, Jonsson, Friederike, De Chaisemartin, Luc, Granger, Vanessa, Gillis, Caitlin, Gouel, Aurelie, Neukirch, Catherine, Dib, Fadia, Nicaise, Pascale Roland, Longrois, Dan, Tubach, Florence, Martin, Sylvie, Bruhns, Pierre, Chen, Kai-Lung, Liao, Shu-Ling, Sheen, Yi-Shuan, Cho, Yung-Tsu, Yang, Che-Wen, Liau, Jau-Yu, Chu, Chia-Yu, Aguiar, Rita, Lopes, Anabela, Fernandes, Natália, Viegas, Leonor, Pereira-Barbosa, M. A., Bünter, Antonia, Gupta, Nisha, Petkovic, Tatjana Pecaric, Wirth, Nicole, Pichler, Werner J., Hausmann, Oliver, Yazicioglu, Mehtap, Ozdemir, Pinar G., Ciplak, Gokce, Kaya, Ozkan, Cooke, Peter John, Mota, Inês, Gaspar, Ângela, Benito-Garcia, Filipe, Chambel, Marta, Morais-Almeida, Mário, Marques, Luis, Alcoceba, Eva, Lara, Silvia, Carneiro-Leão, Leonor, Botelho, Carmen, Dias-Castro, Eunice, Cernadas, Josefina R., Nicholls, Katherine, Lay, William, Smith, Olivia, Collins, Christine, Unglik, Gary, Spriggs, Kymble, Auyeung, Priscilla, McComish, Jeremy, Douglass, Jo A., Peter, Jonny G., Potter, Paul, Carolino, Fabrícia, De Castro, Eunice Dias, Moreira, Ana Sofia, Abreu, Carmo, Gomes, Eva, Cardoso, Bárbara Kong, Tomaz, Elza, Correia, Sara, Inácio, Filipe, Arnold, Annabelle, Bear, Natasha, Rueter, Kristina, Gong, Grace, O’Sullivan, Michael, Muthusamy, Saravanan, Noble, Valerie, Lucas, Michaela, Buterleviciute, Neringa, Rudzeviciene, Odilija, May, Sara, Pongdee, Thanai, Park, Miguel, Griguola, Linas, Vinikovas, Arturas, Kašinskaite, Simona, Kvedariene, Violeta, Aktas, Ayse, Rahman, Suheyla, Elbi, Huseyin, Ozyurt, Beyhan Cengiz, Cavkaytar, Ozlem, Karaatmaca, Betul, Cetinkaya, Pinar Gur, Esenboga, Saliha, Sahiner, Umit M., Sekerel, Bulent E., Soyer, Ozge, Zubrinich, Celia, Tong, Bianca, Patel, Mittal, Giles, Michelle, O’Hehir, Robyn, Puy, Robert, Amaral, Luís, Demir, Semra, Gelincik, Asli, Olgac, Muge, Caskun, Raif, Unal, Derya, Colakoglu, Bahauddin, Buyukozturk, Suna, Matute, Olga Vega, Bernad, Amalia, Gastaminza, Gabriel, Madamba, Roselle, Lacasa, Carlos, Goikoetxea, M. J., D’Amelio, Carmen, Rifón, Jose, Martínez, Nicolas, Ferrer, Marta, Ribeiro, Carmelita, Faria, Emília, Frutuoso, Cristina, Barros, Anabela, Lebre, Rosário, Pego, Alice, Bom, Ana Todo, Ensina, Luis Felipe, Aranda, Carolina, Nunes, Ines Camelo, Martins, Ana Maria, Solé, Dirceu, Bavbek, Sevim, Kendirlinan, Resat, Çerçi, Pamir, Tutluer, Seda, Soyyigit, Sadan, Sözener, Zeynep Çelebi, Aydin, Ömür, Gümüsburun, Reyhan, Almeida, Marta, Sai, Kimie, Imatoh, Takuya, Nakamura, Ryosuke, Fukazawa, Chisato, Hinomura, Yasushi, Saito, Yoshiro, Sousa-Pinto, Bernardo, Correia, Cláudia, Gomes, Lídia, Gil-Mata, Sara, Araújo, Luís, Delgado, Luís, Okamoto-Uchida, Yoshimi, Kajinami, Koji, Matsunaga, Kayoko, Aihara, Michiko, Wang, Chuang-Wei, Su, Shih-Chi, Hung, Shuen-Iu, Ho, Hsin-Chun, Yang, Chih-Hsun, Paulmann, Maren, Dunant, Ariane, Mockenhaupt, Maja, Sekula, Peggy, Schumacher, Martin, Kardaun, Sylvia, Naldi, Luigi, Bellón, Teresa, Creamer, Daniel, Haddad, Cynthia, Sassolas, Bruno, Lebrun-Vignes, Bénédicte, Valeyrie-Allanore, Laurence, Roujeau, Jean-Claude, Kremmler, Carmen, Dodiuk-Gad, Roni P., Olteanu, Cristina, Feinstein, Anthony, Hashimoto, Rena, Alhusayen, Raed, Whyte-Croasdaile, Sonia, Finkelstein, Yaron, Burnett, Marjorie, Sade, Shachar, Cartotto, Robert, Jeschke, Marc, Shear, Neil H., Takamura, Naoko, Yamane, Yumiko, Matsukura, Setsuko, Nakamura, Kazuko, Watanabe, Yuko, Yamaguchi, Yukie, Kambara, Takeshi, Ikezawa, Zenro, Chew, Hall, Knezevic, Brittany, Ionmhain, Una Nic, Barraclough, Allison, Anstey, Matthew, Usui, Toru, Meng, Xiaoli, Farrell, John, Whitaker, Paul, Watson, John, French, Neil, Park, Kevin, Naisbitt, Dean, Neves, Ana Castro, Cadinha, Susana, Moreira, Ana, Da Silva, J. P. Moreira, Drvar, Daniela Ledic, Gulin, Sandra Jerkovic, Hadzavdic, Suzana Ljubojevic, Ceovic, Romana, De Francisco, Ana Montoro, De Vicente Jiménez, Talía, Luque, Amelia García, David, Natalia Rosado, Galván, José Mª Mateos, Darlenski, Razvigor, Gulin, Dario, Sikic, Jozica, Habek, Jasna Cerkez, Galic, Edvard, Specht, Philip, Staab, Doris, Mayer, Beate, Roehmel, Jobst, Solovan, Caius, Chiriac, Anca, Djurinec, Paola, Kostovic, Kresimir, Bradamante, Mirna, Almeida, Jose Pedro, Caiado, Joana, Pedro, Elisa, Da Silva, Pedro Canas, Barbosa, Manuel Pereira, Bogas, Gador, Blanca-López, Natalia, Pérez-Alzate, Diana, Doña, Inmaculada, Agúndez, José Augusto, García-Martín, Elena, Cornejo-García, José Antonio, Mayorga, Cristobalina, Torres, María José, Canto, Maria Gabriela, Blanca, Miguel, Aksakal, Sengül, Sin, Aytül Zerrin, Koç, Zeynep Peker, Günsen, Fatma Düsünür, Ardeniz, Ömür, Gökmen, Emine Nihal Mete, Gülbahar, Okan, Kokuludag, Ali, Pérez-Sánchez, Natalia, Salas, María, Salas, Maria, Gomez, Francisca, Barrionuevo, Esther, Andreu, Inmaculada, Miranda, Miguel Ángel, Didžiokaite, Gabija, Gaidej, Olesia, Garcimartin, Maria Isabel, Somoza, Maria Luisa, Bojas, Gador, Cornejo-Garcia, Jose Antonio, Perez, Francisco Javier Ruano, Miranda, Miguel Angel, Jerschow, Elina, Pelletier, Teresa, Ren, Zhen, Hudes, Golda, Sanak, Marek, Morales, Esperanza, Schuster, Victor, Spivack, Simon D, Rosenstreich, David, Erzen, Renato, Silar, Mira, Bajrovic, Nissera, Rijavec, Matija, Zidarn, Mihaela, Korosec, Peter, Castro, Eunice, Al-Ahmad, Mona, Rodriguez, Tito, Azevedo, João Pedro, Tavares, Beatriz, Regateiro, Frederico, Todo-Bom, Ana, Miranda, Pablo Andrés, De La Cruz Hoyos, Bautista, Abuzeid, Waleed, Akbar, Nadeem, Gibber, Marc, Fried, Marvin, Han, Weiguo, Keskin, Taha, Tamayev, Robert, Spivack, Simon D., Boni, Elisa, Russello, Marina, Mauro, Marina, Neto, Marta Ferreira, Brosseron, Lise, Malheiro, Daniela, Barreira, Patrícia, Sprigg, Dustin, Trevenen, Michelle, Seet, Jason, Trubiano, Jason, Smith, William, Jeelall, Yogesh, Vale, Sandra, Loh, Richard, Mclean-Tooke, Andrew, Müller, Sabine, Amstutz, Ursula, Jörg, Lukas, Yawalkar, Nikhil, Krähenbühl, Stephan, Leblanc, Ana, Ribeiro, Laura, Vega, Arantza, Rivas, Raquel Gutierrez, Alonso, Ana, Beitia, Juan Maria, Mateo, Belén, Cárdenas, Remedios, Garcia-Dominguez, Juan Jesus, Strautins, Kaija, James, Ian, Neves, Ana, Do Céu Machado, Maria, Dalgiç, Ceyda Tunakan, Bulut, Gökten, Ardeniz, Fatma Ömür, Hsu, Shao-Hsuan, Ye, Young-Min, Hur, Gyu-Young, Park, Hae-Sim, Kim, Seung-Hyun, Ali, Syed, Hollingsworth, Peter N., Mclean-Tooke, Andrew P. C., Chadly, Zohra, Fredj, Nadia Ben, Aouam, Karim, Romdhane, Haifa Ben, Boughattas, Naceur A., Chaabane, Amel, Salazar, Marina Lluncor, Pola, Beatriz, Fiandor, Ana, Ramírez, Elena, Ortega, Javier Domínguez, Quirce, Santiago, Cabañas, Rosario, Baynova, Krasimira, Labella, Marina, Prados, Manuel, Ramonaite, Agne, Bajoriuniene, Ieva, Sitkauskiene, Brigita, Sakalauskas, Raimundas, Kwon, Jae-Woo, Park, Shinyoung, Silva, Diana, Leão, Leonor Carneiro, Garcimartin, Maria, De La Torre, Maria Vazquez, Pérez, Francisco Javier Ruano, Haroun, Elisa, Diez, Gabriela Canto, Ónodi-Nagy, Katinka, Kinyó, Ágnes, Kemény, Lajos, Bata-Csörgo, Zsuzsanna, Pita, Joana Sofia, Fernandes, Rosa Anita, Moura, Ana, Sousa, Nuno, Loureiro, Carlos, Pfützner, Wolfgang, Marrouche, Nadine, Grattan, Clive, Chen, Yu-En, Chen, Chun-Bing, Hsiao, Yu-Ping, and Ruano, Francisco Javier

Subjects
Pulmonary and Respiratory Medicine, Drug, Allergy, business.industry, media_common.quotation_subject, Immunology, medicine.disease, Meeting Abstracts, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Drug Hypersensitivity Syndrome, 030220 oncology & carcinogenesis, Immunology and Allergy, Medicine, business, media_common
Abstract

Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE? Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09) P1 Anaphylactic reactions during anaesthesia and the perioperative period Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine? Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann P3 Cefotaxime-induced severe anaphylaxis in a neonate Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine Peter John Cooke P5 Drug-induced anaphylaxis: five-year single-center survey Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida P6 Intraoperative severe anaphylactic reaction due to patent blue v dye Luis Marques, Eva Alcoceba, Silvia Lara P7 Kounis syndrome in the setting of anaphylaxis to diclofenac Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass P9 Recurrent peri-operative anaphylaxis: a perfect storm Jonny G. Peter, Paul Potter Poster Walk 2: DH regions and patient groups (P10–P19) P10 A rare presentation of amoxicillin allergy in a young child Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas P11 Adverse drug reactions in children: antibiotics or virus? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P12 Allergic reactions in invasive medical procedures Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio P13 Antibiotic allergy in children: room for improvement Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation Neringa Buterleviciute, Odilija Rudzeviciene P15 Nonimmediate cutaneous drug reactions in children: are skin tests required? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies Sara May, Thanai Pongdee, Miguel Park P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt P19 Severe drug hypersensitivity reactions in pediatric age Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer Poster Walk 3: Desensitisation (P20–P28) P20 A protocol for desensitisation to valaciclovir Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy P21 A rare case of desensitization to modafinil Josefina Cernadas, Luís Amaral, Fabrícia Carolino P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom P25 Filgrastim anaphylaxis: a successful desensitization protocol Luis Amaral, Josefina Cernadas P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida Poster Walk 4: SJS (P29–P38) P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey Poster Walk 5: Other organs/unexpected immune reactions (P39–P47) P39 A case report of patient with anti-tuberculosis drug-related severe liver failure Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt P40 Acute interstitial nephritis induced by ibuprofen Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva P41 Cetuximab induced acneiform rash—two case reports Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic P42 Enteropathy associated with losartan Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván P43 Granuloma annulare after therapy with canakinumab Razvigor Darlenski P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel P46 Progesterone triggered pemphigus foliaceus: case report Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac P47 Ramipril: triggered generalized pustular psoriasis Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic Poster Walk 6: NSAIDs (P48–P56) P48 Aspirin desensitization in cardiovascular disease—Portuguese experience Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich Poster Walk 7: NSAID 2 (P57–P65) P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec P58 Anaphylaxis to diclofenac: what about the underlying mechanism? Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs? Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty Mona Al-Ahmad, Tito Rodriguez P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema Elisa Boni, Marina Russello, Marina Mauro P65 Selective hypersensitivity reactions to ibuprofen—seven years experience Marta Ferreira Neto Poster Walk 8: Epidemiological methods (P66–P72) P66 Allopurinol hypersensitivity: a 7-year review Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015 Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl P70 Patients with suspected drug allergy: a specific psychological profile? Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips Poster Walk 9: DRESS/AGEP (P73–P81) P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report Krasimira Baynova, Marina Labella, Manuel Prados P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91) P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test Jae-Woo Kwon, Shinyoung Park P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas P84 Allergy to heparins Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez P85 Allopurinol-induced adverse drug reactions Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure Wolfgang Pfützner P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox? Nadine Marrouche, Clive Grattan P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-Ping Hsiao, Chia-Yu Chu P90 Diagnosis of allergic reactions to eye drops Maria Vazquez De La Torre, Natalia Blanca-Lopez, Diana Perez-Alzate, Maria Isabel Garcimartin, Francisco Javier Ruano, Maria Luisa Somoza, Elisa Haroun, Gabriela Canto P91 Diagnostic approach in suspected hypersensitivity reactions to corticosteroids Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas

Published
2016

150. Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study

Author

Lortholary, Olivier, primary, Chandesris, Marie Olivia, additional, Livideanu, Cristina Bulai, additional, Paul, Carle, additional, Guillet, Gérard, additional, Jassem, Ewa, additional, Niedoszytko, Marek, additional, Barete, Stéphane, additional, Verstovsek, Srdan, additional, Grattan, Clive, additional, Damaj, Gandhi, additional, Canioni, Danielle, additional, Fraitag, Sylvie, additional, Lhermitte, Ludovic, additional, Lavialle, Sophie Georgin, additional, Frenzel, Laurent, additional, Afrin, Lawrence B., additional, Hanssens, Katia, additional, Agopian, Julie, additional, Gaillard, Raphael, additional, Kinet, Jean-Pierre, additional, Auclair, Christian, additional, Mansfield, Colin, additional, Moussy, Alain, additional, Dubreuil, Patrice, additional, and Hermine, Olivier, additional

Published
2017
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