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104. Beyond alpha power: EEG spatial and spectral gradients robustly stratify disorders of consciousness

Author

Colombo, Michele Angelo, primary, Comanducci, Angela, additional, Casarotto, Silvia, additional, Derchi, Chiara-Camilla, additional, Annen, Jitka, additional, Viganò, Alessandro, additional, Mazza, Alice, additional, Trimarchi, Pietro Davide, additional, Boly, Melanie, additional, Fecchio, Matteo, additional, Bodart, Olivier, additional, Navarro, Jorge, additional, Laureys, Steven, additional, Gosseries, Olivia, additional, Massimini, Marcello, additional, Sarasso, Simone, additional, and Rosanova, Mario, additional

Published
2023
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113. Functional Imaging and Impaired Consciousness

Author

Vanhaudenhuyse, Audrey, Boly, Melanie, Bruno, Marie-Aurélie, Gosseries, Olivia, Demertzi, Athena, Kirsch, Murielle, Tshibanda, Jean-Flory Luaba, Thonnard, Marie, Charland-Verville, Vanessa, Chatelle, Camille, Thibaut, Aurore, Laureys, Steven, Soddu, Andrea, Schnakers, Caroline, editor, and Laureys, Steven, editor

Published
2012
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115. The Ethics of Managing Disorders of Consciousness

Author

Demertzi, Athena, Gosseries, Olivia, Bruno, Marie-Aurélie, Schnakers, Caroline, Vanhaudenhuyse, Audrey, Chatelle, Camille, Charland-Verville, Vanessa, Thibaut, Aurore, Thonnard, Marie, Laureys, Steven, Schnakers, Caroline, editor, and Laureys, Steven, editor

Published
2012
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119. Predicting Long-Term Recovery of Consciousness in Prolonged Disorders of Consciousness Based on Coma Recovery Scale-Revised Subscores: Validation of a Machine Learning-Based Prognostic Index

Author

Magliacano, Alfonso, primary, Liuzzi, Piergiuseppe, additional, Formisano, Rita, additional, Grippo, Antonello, additional, Angelakis, Efthymios, additional, Thibaut, Aurore, additional, Gosseries, Olivia, additional, Lamberti, Gianfranco, additional, Noé, Enrique, additional, Bagnato, Sergio, additional, Edlow, Brian L., additional, Lejeune, Nicolas, additional, Veeramuthu, Vigneswaran, additional, Trojano, Luigi, additional, Zasler, Nathan, additional, Schnakers, Caroline, additional, Bartolo, Michelangelo, additional, Mannini, Andrea, additional, and Estraneo, Anna, additional

Published
2022
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120. What is the nutritional status of patients with prolonged disorders of consciousness? A retrospective cross-sectional study

Author

Ippoliti, Camilla, primary, Fadeur, Marjorie, additional, Malherbe, Christian, additional, De Flines, Jenny, additional, Verbrugge, Anne-Marie, additional, Gosseries, Olivia, additional, Ledoux, Didier, additional, Misset, Benoit, additional, Laureys, Steven, additional, Paquot, Nicolas, additional, and Thibaut, Aurore, additional

Published
2022
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121. Virtual reality hypnosis in the management of pain: Self‐reported and neurophysiological measures in healthy subjects

Author

Rousseaux, Floriane, primary, Panda, Rajanikant, additional, Toussaint, Clémence, additional, Bicego, Aminata, additional, Niimi, Masachika, additional, Faymonville, Marie‐Elisabeth, additional, Nyssen, Anne‐Sophie, additional, Laureys, Steven, additional, Gosseries, Olivia, additional, and Vanhaudenhuyse, Audrey, additional

Published
2022
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124. Editorial: Coma and disorders of consciousness: an overview.

Author

Mainali, Shraddha, O'Hana Nobleza, Christa, Edlow, Brian L., Polizzotto, Leonard, Dangayach, Neha, Sarwal, Aarti, and Gosseries, Olivia

Subjects
TRANSCRANIAL direct current stimulation, CONSCIOUSNESS disorders, TRANSCRANIAL magnetic stimulation, PERSISTENT vegetative state, COMA, PATIENTS' families
Abstract

This article is an editorial that provides an overview of coma and disorders of consciousness (DoC). It highlights the complex challenges and the need for innovative therapeutic interventions in this field. The editorial reviews 13 scholarly articles that cover various aspects of research and clinical practice related to DoC, including diagnosis, treatment, rehabilitation, and ethical considerations. The articles emphasize the importance of accurate diagnosis, specialized rehabilitation, neuromodulation techniques, and personalized treatment strategies. Overall, the collection of articles aims to improve the understanding and management of patients with coma and DoC. [Extracted from the article]

Published
2024
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131. Low-dimensional organization of global brain states of reduced consciousness

Author

Perl, Yonatan Sanz, primary, Pallavicini, Carla, additional, Piccinini, Juan, additional, Demertzi, Athena, additional, Bonhomme, Vincent, additional, Martial, Charlotte, additional, Panda, Rajanikant, additional, Alnagger, Naji, additional, Annen, Jitka, additional, Gosseries, Olivia, additional, Ibañez, Agustin, additional, Laufs, Helmut, additional, Sitt, Jacobo, additional, Jirsa, Viktor, additional, Kringelbach, Morten, additional, Laureys, Steven, additional, Deco, Gustavo, additional, and Tagliazucchi, Enzo, additional

Published
2022
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132. What lies underneath: Precise classification of brain states using time-dependent topological structure of dynamics

Author

Soler-Toscano, Fernando, primary, Galadí, Javier A., additional, Escrichs, Anira, additional, Sanz Perl, Yonatan, additional, López-González, Ane, additional, Sitt, Jacobo D., additional, Annen, Jitka, additional, Gosseries, Olivia, additional, Thibaut, Aurore, additional, Panda, Rajanikant, additional, Esteban, Francisco J., additional, Laureys, Steven, additional, Kringelbach, Morten L., additional, Langa, José A., additional, and Deco, Gustavo, additional

Published
2022
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134. What names for covert awareness? A systematic review

Author

Schnakers, Caroline, primary, Bauer, Chase, additional, Formisano, Rita, additional, Noé, Enrique, additional, Llorens, Roberto, additional, Lejeune, Nicolas, additional, Farisco, Michele, additional, Teixeira, Liliana, additional, Morrissey, Ann-Marie, additional, De Marco, Sabrina, additional, Veeramuthu, Vigneswaran, additional, Ilina, Kseniya, additional, Edlow, Brian L., additional, Gosseries, Olivia, additional, Zandalasini, Matteo, additional, De Bellis, Francesco, additional, Thibaut, Aurore, additional, and Estraneo, Anna, additional

Published
2022
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135. Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness

Author

Panda, Rajanikant, primary, Thibaut, Aurore, additional, Lopez-Gonzalez, Ane, additional, Escrichs, Anira, additional, Bahri, Mohamed Ali, additional, Hillebrand, Arjan, additional, Deco, Gustavo, additional, Laureys, Steven, additional, Gosseries, Olivia, additional, Annen, Jitka, additional, and Tewarie, Prejaas, additional

Published
2022
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136. Author response: Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness

Author

Panda, Rajanikant, primary, Thibaut, Aurore, additional, Lopez-Gonzalez, Ane, additional, Escrichs, Anira, additional, Bahri, Mohamed Ali, additional, Hillebrand, Arjan, additional, Deco, Gustavo, additional, Laureys, Steven, additional, Gosseries, Olivia, additional, Annen, Jitka, additional, and Tewarie, Prejaas, additional

Published
2022
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140. What names for covert awareness? : A systematic review

Author

Schnakers, Caroline, Bauer, Chase, Formisano, Rita, Noé, Enrique, Llorens, Roberto, Lejeune, Nicolas, Farisco, Michele, Teixeira, Liliana, Morrissey, Ann-Marie, De Marco, Sabrina, Veeramuthu, Vigneswaran, Ilina, Kseniya, Edlow, Brian L., Gosseries, Olivia, Zandalasini, Matteo, De Bellis, Francesco, Thibaut, Aurore, Estraneo, Anna, Schnakers, Caroline, Bauer, Chase, Formisano, Rita, Noé, Enrique, Llorens, Roberto, Lejeune, Nicolas, Farisco, Michele, Teixeira, Liliana, Morrissey, Ann-Marie, De Marco, Sabrina, Veeramuthu, Vigneswaran, Ilina, Kseniya, Edlow, Brian L., Gosseries, Olivia, Zandalasini, Matteo, De Bellis, Francesco, Thibaut, Aurore, and Estraneo, Anna

Abstract

Background: With the emergence of Brain Computer Interfaces (BCI), clinicians have been facing a new group of patients with severe acquired brain injury who are unable to show any behavioral sign of consciousness but respond to active neuroimaging or electrophysiological paradigms. However, even though well documented, there is still no consensus regarding the nomenclature for this clinical entity. Objectives: This systematic review aims to 1) identify the terms used to indicate the presence of this entity through the years, and 2) promote an informed discussion regarding the rationale for these names and the best candidates to name this fascinating disorder. Methods: The Disorders of Consciousness Special Interest Group (DoC SIG) of the International Brain Injury Association (IBIA) launched a search on Pubmed and Google scholar following PRISMA guidelines to collect peer-reviewed articles and reviews on human adults (>18 years) published in English between 2006 and 2021. Results: The search launched in January 2021 identified 4,089 potentially relevant titles. After screening, 1,126 abstracts were found relevant. Finally, 161 manuscripts were included in our analyses. Only 58% of the manuscripts used a specific name to discuss this clinical entity, among which 32% used several names interchangeably throughout the text. We found 25 different names given to this entity. The five following names were the ones the most frequently used: covert awareness, cognitive motor dissociation, functional locked-in, non-behavioral MCS (MCS*) and higher-order cortex motor dissociation. Conclusion: Since 2006, there has been no agreement regarding the taxonomy to use for unresponsive patients who are able to respond to active neuroimaging or electrophysiological paradigms. Developing a standard taxonomy is an important goal for future research studies and clinical translation. We recommend a Delphi study in order to build such a consensus., The Human Brain Project

Published
2022
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141. What lies underneath: Precise classification of brain states using time-dependent topological structure of dynamics

Author

Universidad de Sevilla. Departamento de Filosofía y Lógica y Filosofía de la Ciencia, Universidad de Sevilla. Departamento de Ecuaciones Diferenciales y Análisis Numérico, Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Universidad de Jaén, Fundación Alicia Koplowitz, Unión Europea. Horizonte 2020, Swiss National Science Foundation, Fonds de la Recherche Scientifique (FNRS). Bélgica, National Natural Science Foundation of China, Soler Toscano, Fernando, Galadí García, Javier Alejandro, Escrichs, Anira, Sanz Perl, Y., López González, Ane, Sitt, Jacobo D., Annen, Jitka, Gosseries, Olivia, Thibaut, Aurore, Panda, Rajanikant, Esteban, Francisco J., Laureys, Steven, Kringelbach, M.L., Langa Rosado, José Antonio, Deco, Gustavo, Universidad de Sevilla. Departamento de Filosofía y Lógica y Filosofía de la Ciencia, Universidad de Sevilla. Departamento de Ecuaciones Diferenciales y Análisis Numérico, Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Universidad de Jaén, Fundación Alicia Koplowitz, Unión Europea. Horizonte 2020, Swiss National Science Foundation, Fonds de la Recherche Scientifique (FNRS). Bélgica, National Natural Science Foundation of China, Soler Toscano, Fernando, Galadí García, Javier Alejandro, Escrichs, Anira, Sanz Perl, Y., López González, Ane, Sitt, Jacobo D., Annen, Jitka, Gosseries, Olivia, Thibaut, Aurore, Panda, Rajanikant, Esteban, Francisco J., Laureys, Steven, Kringelbach, M.L., Langa Rosado, José Antonio, and Deco, Gustavo

Abstract

The self-organising global dynamics underlying brain states emerge from complex recursive nonlinear interactions between interconnected brain regions. Until now, most efforts of capturing the causal mechanistic generating principles have supposed underlying stationarity, being unable to describe the non-stationarity of brain dynamics, i.e. time-dependent changes. Here, we present a novel framework able to characterise brain states with high specificity, precisely by modelling the time-dependent dynamics. Through describing a topological structure associated to the brain state at each moment in time (its attractor or ‘information structure’), we are able to classify different brain states by using the statistics across time of these structures hitherto hidden in the neuroimaging dynamics. Proving the strong potential of this framework, we were able to classify resting-state BOLD fMRI signals from two classes of post-comatose patients (minimally conscious state and unresponsive wakefulness syndrome) compared with healthy controls with very high precision.

Published
2022

142. Studying death and near-death experiences requires neuroscientific expertise

Author

Martial, Charlotte, Gosseries, Olivia, Cassol, Héléna, Kondziella, Daniel, Martial, Charlotte, Gosseries, Olivia, Cassol, Héléna, and Kondziella, Daniel

Abstract

Parnia et al. recently published suggestions for the study of death and experiences recalled in a near-death context. We have serious reservations about the authors’ statements. In this commentary, we discuss the omissions and knowledge gaps inherent to the authors’ paper, which among others include incorrect neurological claims about brain death and misunderstandings regarding the terminology of consciousness. Although we believe that (near-)death research deserves a framework guideline, the paper by Parnia and colleagues is misleading and, contrary to the authors' intention, hinders the scientific understanding of near-death experiences and the neural mechanisms occurring in the dying brain.

Published
2022

143. Hypnosis, Meditation, and Self-Induced Cognitive Trance to Improve Post-treatment Oncological Patients’ Quality of Life: Study Protocol

Author

Grégoire, Charlotte, Marie, Nolwenn, Sombrun, Corine, Faymonville, Marie-Elisabeth, Kotsou, Ilios, van Nitsen, Valérie, de Ribaucourt, Sybille, Jerusalem, Guy, Laureys, Steven, Vanhaudenhuyse, Audrey, Gosseries, Olivia, Grégoire, Charlotte, Marie, Nolwenn, Sombrun, Corine, Faymonville, Marie-Elisabeth, Kotsou, Ilios, van Nitsen, Valérie, de Ribaucourt, Sybille, Jerusalem, Guy, Laureys, Steven, Vanhaudenhuyse, Audrey, and Gosseries, Olivia

Abstract

Introduction A symptom cluster is very common among oncological patients: cancer-related fatigue (CRF), emotional distress, sleep difficulties, pain, and cognitive difficulties. Clinical applications of interventions based on non-ordinary states of consciousness, mostly hypnosis and meditation, are starting to be investigated in oncology settings. They revealed encouraging results in terms of improvements of these symptoms. However, these studies often focused on breast cancer patients, with methodological limitations (e.g. small sample size, no control group, and no follow-up). Another non-ordinary state of consciousness may also have therapeutic applications in oncology: self-induced cognitive trance (SICT). It seems to differ from hypnosis and meditation, as it involves the body more directly. Thus, investigating its clinical applications, along with hypnosis and meditation interventions, could improve available therapeutic options in oncology. This article details the study protocol of a preference-based longitudinal controlled superiority trial aiming to assess the effectiveness of 3 group interventions (hypnosis, meditation, and SICT) to improve oncological patients’ quality of life, and more specifically CRF, emotional distress, sleep, pain, and cognitive difficulties (primary outcomes). Methods and analysis A power analysis required a total sample of 160 patients. Main inclusion criteria are: cancer diagnosis, active treatments completed for less than a year, no practice of hypnosis, meditation, or SICT, and presence of at least one of these four symptoms: fatigue, sleep difficulties, depression, or anxiety. Each participant will choose the intervention in which they want to participate (hypnosis, mindful self-compassion meditation, SICT, or no intervention—control group). To test the effectiveness of the interventions, data will be collected by questionnaires and neurobiological measures and directly from the medical record at four time points: before inclu, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

144. Sedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity

Author

Kirsch, Muriëlle, Guldenmund, Pieter, Ali Bahri, Mohamed, Demertzi, Athena, Baquero, Katherine, Heine, Lizette, Charland-Verville, Vanessa, Vanhaudenhuyse, Audrey, Bruno, Marie-Aurélie, Gosseries, Olivia, Di Perri, Carol, Ziegler, Erik, Brichant, Jean-François, Soddu, Andrea, Bonhomme, Vincent, and Laureys, Steven

Published
2017
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146. The Human Affectome

Author

Schiller, Daniela, primary, Yu, Alessandra Nicoletta Cruz, additional, Alia-Klein, Nelly, additional, Becker, Susanne, additional, Cromwell, Howard Casey, additional, Dolcos, Florin, additional, Eslinger, Paul J., additional, Frewen, Paul, additional, Kemp, Andrew Haddon, additional, Pace-Schott, Edward, additional, Raber, Jacob, additional, Silton, Rebecca Levin, additional, Stefanova, Elka, additional, Williams, Justin H. G., additional, Abe, Nobuhito, additional, Aghajani, Moji, additional, Albrecht, Franziska, additional, Alexander, Rebecca, additional, Anders, Silke, additional, Aragón, Oriana R., additional, Arias, Juan A, additional, Arzy, Shahar, additional, Aue, Tatjana, additional, Baez, Sandra, additional, Balconi, Michela, additional, Ballarini, Tommaso, additional, Bannister, Scott, additional, Amole, Marlissa C., additional, Barrett, Karen Caplovitz, additional, Belzung, Catherine, additional, Bensafi, Moustafa, additional, Booij, Linda, additional, Bookwala, Jamila, additional, Boulanger-Bertolus, Julie, additional, Boutros, Sydney Weber, additional, Bräscher, Anne-Kathrin, additional, Bruno, Antonio, additional, Busatto, Geraldo, additional, Bylsma, Lauren, additional, Caldwell-Harris, Catherine, additional, Chan, Raymond C. K., additional, Cherbuin, Nicolas, additional, Chiarella, Julian, additional, Cipresso, Pietro, additional, Critchley, HUgo, additional, Croote, Denise, additional, Demaree, Heath A., additional, Denson, Thomas F, additional, Depue, Brendan, additional, Dernt, Birgit, additional, Dickson, Joanne M., additional, Dolcos, Sanda, additional, Drach-Zahavy, Anat, additional, Dubljević, Olga, additional, Eerola, Tuomas, additional, Ellingsen, Dan-Mikael, additional, Fairfield, Beth, additional, Ferdenzi, Camille, additional, Scarpa-Friedman, Bruce H, additional, Fu, Cynthia H.Y., additional, Gatt, Justine, additional, de Gelder, Beatrice, additional, Gendolla, Guido H. E., additional, Gilam, Gadi, additional, Goldblatt, Hadass, additional, Kotynski, Anne, additional, Gosseries, Olivia, additional, Hamm, Alfons O., additional, Hanson, Jamie Lars, additional, Hendler, Talma, additional, Herbert, Cornelia, additional, Hofmann, Stefan G., additional, Ibanez, Agustin, additional, Joffily, Mateus, additional, Jovanovic, Tanja, additional, Kahrilas, Ian J., additional, Kangas, Maria, additional, Katsumi, Yuta, additional, Kensinger, Elizabeth, additional, Kirby, Lauren A. J., additional, Koncz, Rebecca, additional, Koster, Ernst H. W., additional, Kozlowska, Kasia, additional, Krach, Sören, additional, Kret, Mariska, additional, Krippl, Martin, additional, Kusi-Mensah, Kwabena, additional, Ladouceur, Cecile D., additional, Laureys, Steven, additional, Lawrence, Alistair, additional, Li, Chiang-Shan R., additional, Liddell, Belinda, additional, Lidhar, Navdeep K., additional, Lowry, Christopher A., additional, Magee, Kelsey, additional, Marin, Marie-France, additional, Mariotti, Veronica, additional, Martin, Loren, additional, Marusak, Hilary A., additional, Mayer, Annalina V., additional, Merner, Amanda R., additional, Minnier, Jessica, additional, Moll, Jorge, additional, Morrison, Robert, additional, Moore, Matthew, additional, Mouly, Anne-Marie, additional, Mueller, Sven C, additional, Mühlberger, Andreas, additional, Murphy, Nora A., additional, Muscatello, Maria Rosaria Anna, additional, Musser, Erica D., additional, Newton, Tamara L., additional, Noll-Hussong, Michael, additional, Norrholm, Seth Davin, additional, Northoff, Georg, additional, Nusslock, Robin, additional, Okon-Singer, Hadas, additional, Olino, Thomas M, additional, Ortner, Catherine Nicole Marie, additional, Owolabi, Mayowa, additional, Padulo, Caterina, additional, Palermo, Romina, additional, Palumbo, Rocco, additional, Palumbo, Sara, additional, Papadelis, Christos, additional, Pegna, Alan J., additional, Pellegrini, Silvia, additional, Peltonen, Kirsi, additional, Penninx, Brenda, additional, Pietrini, Pietro, additional, Pinna, Graziano, additional, Pintos Lobo, Rosario, additional, Polnaszek, Kelly L, additional, Polyakova, Maryna, additional, Rabinak, Christine, additional, Richter, S. Helene, additional, Richter, Thalia, additional, Riva, Giuseppe, additional, Rizzo, Amelia, additional, Robinson, Jennifer L., additional, Rosa, Pedro, additional, Sachdev, Perminder S, additional, Satomi, Wataru, additional, Schroeter, Matthias L., additional, Schweizer, Susanne, additional, Shiban, Youssef, additional, Siddharthan, Advaith, additional, Siedlecka, Ewa, additional, Smith, Robert C., additional, Soreq, Hermona, additional, Spangler, Derek P., additional, Stern, Emily R., additional, Styliadis, Charis, additional, Sullivan, Gavin Brent, additional, Swain, James E., additional, Urben, Sébastien, additional, Van den Stock, Jan, additional, van der Kooij, Michael A., additional, van Overveld, Mark, additional, Van Rheenen, Tamsyn, additional, VanElzakker, Michael B., additional, Ventura-Bort, Carlos, additional, Verona, Edelyn, additional, Volk, Tyler, additional, Wang, Yi, additional, Weingast, Leah T., additional, Weymar, Mathias, additional, Williams, Claire, additional, Willis, Megan, additional, Yamashita, Paula, additional, Zahn, Roland, additional, Zupan, Barbra, additional, and Lowe, Leroy, additional

Published
2022
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150. Preface

Author

Laureys, Steven, primary, Gosseries, Olivia, additional, and Tononi, Giulio, additional

Published
2016
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