3,204 results on '"Giorgianni, A"'
Search Results
102. Optical conductivity of V4O7 across its metal-insulator transition
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Vecchio, I. Lo, Autore, M., D'Apuzzo, F., Giorgianni, F., Perucchi, A., Schade, U., Andreev, V. N., Klimov, V. A., and Lupi, S.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The optical properties of a V4O7 single crystal have been investigated from the high temperature metallic phase down to the low temperature antiferromagnetic insulating one. The temperature dependent behavior of the optical conductivity across the metal-insulator transition (MIT) can be explained in a polaronic scenario. Charge carriers form strongly localized polarons in the insulating phase as suggested by a far-infrared charge gap abruptly opening at T_MIT = 237 K. In the metallic phase instead the presence of a Drude term is indicative of fairly delocalized charges with a moderately renormalized mass m* = 5m_e. The electronic spectral weight is almost recovered on an energy scale of 1 eV, which is much narrower compared to VO2 and V2O3 cases. Those findings suggest that electron-lattice interaction rather than electronic correlation is the driving force for V4O7 metal-insulator transition., Comment: 5 pages, 3 figures
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- 2014
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103. Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient
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Princiotta Cariddi, Lucia, Tabaee Damavandi, Payam, Carimati, Federico, Banfi, Paola, Clemenzi, Alessandro, Marelli, Margherita, Giorgianni, Andrea, Vinacci, Gabriele, Mauri, Marco, and Versino, Maurizio
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- 2020
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104. Identifying single-item faked responses in personality tests: A new TF-IDF-based method.
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Alberto Purpura, Dora Giorgianni, Graziella Orrù, Giulia Melis, and Giuseppe Sartori
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Medicine ,Science - Abstract
Faking in a psychological test is often observed whenever an examinee may gain an advantage from it. Although techniques are available to identify a faker, they cannot identify the specific questions distorted by faking. This work evaluates the effectiveness of term frequency-inverse document frequency (TF-IDF)-an information retrieval mathematical tool used in search engines and language representations-in identifying single-item faked responses. We validated the technique on three datasets containing responses to the 10-item Big Five questionnaire (total of 694 participants, respectively 221, 243, and 230) in three faking situations. Each participant responded twice, once faking to achieve an objective in one of three contexts (one to obtain child custody and two to land a job) and once honestly. The proposed TF-IDF model has proven very effective in separating honest from dishonest responses-with the honest ones having low TF-IDF values and the dishonest ones having higher values-and in identifying which of the 10 responses to the questionnaire were distorted in the dishonest condition. We also provide examples of the technique in a single-case evaluation.
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- 2022
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105. Upper Limb Disorders in Catering Workers
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Concetto Giorgianni, Francesco Principato, and Giovanna Spatari
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handling weight ,work-related musculoskeletal disorders ,occupational health hazards ,Medicine - Abstract
Background: The literature reports that catering workers are exposed to various occupational health hazardsé. Objective: This study aims to assess a cohort of catering workers in relation to upper limb disorders, thus contributing to the quantification of work-related musculoskeletal disorders in this occupational sector. Methods: Here, 500 employees, of which 130 were males and 370 were females, with an overall mean age of 50.7 years and an average length of service of 24.8 years, were examined. All subjects completed a standardized questionnaire: the medical history questionnaire of diseases of the upper limbs and spine proposed in “Health surveillance of workers”, third edition, EPC. Results: The obtained data enables the following conclusions to be drawn. Musculoskeletal disorders affect a wide range of catering workers. The most affected anatomical region is the shoulder. These disorders increase with advancing age, specifically shoulder, wrist/hand disorders and daytime and nighttime paresthesias. Employment seniority in the catering sector increases the likelihood of all considered conditions. An increase in weekly workload exclusively affects the shoulder region. Conclusions: This study aims to serve as an impetus for further research that seeks to better analyze musculoskeletal problems in the catering sector.
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- 2023
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106. Age-Related Diseases and Foods Generating Chlorinative Stress
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Eleonora Di Salvo, Marco Casciaro, Concetto Mario Giorgianni, Nicola Cicero, and Sebastiano Gangemi
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oxidative stress ,chlorinative stress ,hypochlorus acid ,aging ,old ,elderly ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Aging is a slow and inexorable process affecting all life beings and is characterised by age-related worsening in adaptation to external changes. Several factors contribute to such a process, and oxidative stress due to external damages is one key player. Of particular interest is the oxidative stress generated from halogen compounds such as chloride. Hypochlorus acid is produced starting from MPO’s interaction with hydrogen peroxide. We focused on the oxidation of tyrosine residues by HOCl, which leads as a result to the formation of 3-chlorotyrosine (3-ClTyr). This molecule, due to its stability, is considered a marker for MPO activity. Results: We collected data from literature research articles evaluating chlorinative stress and the effects of 3-ClTyr on chronic diseases linked to aging. As diseases are not the only source of 3-ClTyr in people, we also focused on other origins of chlorinative stress, such as food intake. Discussion: Oxidation and halogenation are caused by infectious diseases and by pathologies characterised by inflammation. Moreover, diet could negatively or positively influence chlorinative stress. Comparing 3-ClTyr levels in the oldest and youngest old with age-related diseases and comparing data between different geographic areas with different pesticide rules could be the next challenge.
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- 2023
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107. Resistin levels and inflammatory and endothelial dysfunction markers in obese postmenopausal women with type 2 diabetes mellitus
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Giandalia, A., Alibrandi, A., Giorgianni, L., Lo Piano, F., Consolo, F., Longo Elia, G., Asztalos, B., Cucinotta, D., Squadrito, G., and Russo, G. T.
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- 2021
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108. Processionary caterpillar reactions in Southern Italy forestry workers: description of three cases
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Ricciardi, Luisa, Giorgianni, Concetto, Briguglio, Giusi, Gangemi, Sebastiano, and Spatari, Giovanna
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- 2021
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109. Alexithymia in an unconventional sample of Forestry Officers: a clinical psychological study with surprising results
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Sebastiano Gangemi, Luisa Ricciardi, Andrea Caputo, Concetto Giorgianni, Fabiana Furci, Giovanna Spatari, and Gabriella Martino
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alexithymia ,clinical psychology ,workers ,psychosomatics ,t.a.s.-20 ,toronto alexithymia scale. ,Psychology ,BF1-990 - Abstract
Background: Clinical psychological dynamics are known as effective in the onset of medical conditions. In this regard, alexithymia represents a well-recognized and studied phenomenon, whose study is attracting academic attention. Its relations with several conditions have found consistent resonance in the clinical fields, so that the application of clinical models to disregarded populations represents a relevant clinical opportunity. The current study was aimed at extending alexithymia study to a population consisting of State Forestry officers, including significant variables as age and years of tenure. Methods: The observation group consisted of 59 State Forestry officers, aged between 48 and 67 years old (SD=3.436). All subjects fully completed the protocol, consisting of the Toronto Alexithymia Scale (TAS-20) and a sociodemographic questionnaire. Descriptive statistics, correlational analyses, dependencies and statistical differences were performed in order to let significant relations emerge. Statistical analyses were performed using SPSS 24.0 for the Window package. Results: Descriptive statistics highlighted high scores related to all alexithymia factors (Difficulty Identifying Feelings, Difficulty Describing Feelings, Externally Oriented Thinking, TAS-20 Total score) in the considered individuals. Correlational analyses provided significant relations with reference to age, years of tenure and the whole set of alexithymic variables. Significant dependencies emerged among the selected predictors (age and years of tenure) and Tas-20 variables (including total score), as well as significant differences between two selected groups (38 and 38 years of tenure). Conclusion: Alexithymia emerged as particularly present in the considered population of State Forestry officers, demonstrating its sensibility with reference to age and years of tenure variables. The study of psychological phenomena affecting general subjects’ condition represent an extension of a present research field of high innovativeness, considering the lack of knowledge referred to the selected sample. Furter studies should increase the number of included individuals in order to favor the extension of the emerged results.
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- 2021
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110. Monitoring Cannabinoids and the Safety of the Trace Element Profile of Light Cannabis sativa L. from Different Varieties and Geographical Origin
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Vincenzo Nava, Ambrogina Albergamo, Giovanni Bartolomeo, Rossana Rando, Federica Litrenta, Giovanna Lo Vecchio, Mario Concetto Giorgianni, and Nicola Cicero
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light cannabis ,hemp ,THC ,CBD ,CBN ,potentially toxic elements ,Chemical technology ,TP1-1185 - Abstract
Non-intoxicating Cannabis sativa L. (i.e., hemp) is increasingly used for industrial, cosmetic and food applications. Despite the fact that the EU has not yet established a regulatory framework on hazardous compounds (i.e., toxic inorganic elements), the monitoring of cannabis products is of paramount importance to safeguard consumers, also in view of the species propensity to accumulate toxic metals from the environment. The aim of this work was to assess the compliance with Law n. 242/2016 and the safety of hemp inflorescences from different varieties and Italian regions by monitoring the main cannabinoids and trace elements. All samples complied with the Italian law due to a THC content
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- 2022
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111. Comaneci-Assisted Coiling of Wide-Necked Intracranial Aneurysm: A Single-Center Preliminary Experience
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Gabriele Vinacci, Angelica Celentano, Edoardo Agosti, Alberto Vito Terrana, Francesco Alberto Vizzari, Luca Nativo, Fabio Baruzzi, Antonio Tabano, Davide Locatelli, and Andrea Giorgianni
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Comaneci ,assisted coiling ,intracranial aneurysm ,embolization ,Medicine - Abstract
Background: Wide-necked aneurysms remain challenging for both coiling and microsurgical clipping. They often require additional techniques to prevent coil prolapse into the parent artery, such as balloon- and stent-assisted coiling. Comaneci is an expandable and removable stent that acts as a bridging device and does not interfere with the blood flow of the parent artery. Methods: We retrospectively reviewed our institutional radiological and clinical chart of patients treated for saccular intracranial aneurysm via endovascular Comaneci-assisted coiling. The aim of the study was to report our preliminary experience in Comaneci-assisted coiling of wide-necked intracranial aneurysms. Results: We included 14 patients in the study. Of these, 11 had a ruptured intracranial aneurysm and were treated with Comaneci-assisted coiling. We registered five minor intraprocedural complications and two intraprocedural failures of the device. At one-year follow-up, a satisfying aneurysm occlusion was observed in 85% of the cases. Conclusions: Though long-term follow-up data and larger case series are needed, this preliminary study showed the feasibility of the Comaneci-assisted coiling method for both ruptured and unruptured wide-neck intracranial aneurysms, with similar occlusion rates as balloon-assisted coiling. However, we registered high incidence of thromboembolic complications; these were probably related to the lack of heparin administration. The main advantageous application of this technique is likely in cases of ruptured intracranial aneurysms, as there is no need for post-procedural antiplatelet therapy.
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- 2022
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112. Association Between Intravitreal Aflibercept and Serious Non-ocular Haemorrhage Compared with Intravitreal Ranibizumab: A Multicentre Observational Cohort Study
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Sultana, Janet, Giorgianni, Francesco, Scondotto, Giulia, Ientile, Valentina, Cananzi, Pasquale, Leoni, Olivia, Addario, Sebastiano Walter Pollina, De Sarro, Giovanbattista, De Francesco, Adele, Puzo, Maria Rosa, Renoux, Christel, and Trifirò, Gianluca
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- 2020
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113. Efficacy of ADAPT with large-bore reperfusion catheter in anterior circulation acute ischemic stroke: a multicentric Italian experience
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Romano, Daniele Giuseppe, Frauenfelder, Giulia, Casseri, Tommaso, Piano, Mariangela, Vinci, Sergio, Comai, Alessio, Stecco, Alessandro, Causin, Francesco, Asteggiano, Francesco, Paolucci, Aldo, Comelli, Chiara, Giorgianni, Andrea, Cirillo, Luigi, Ganci, Giuseppe, Cioni, Samuele, Pitrone, Antonio, Pero, Guglielmo, Papa, Rosario, Muto, Mario, Saponiero, Renato, and Bracco, Sandra
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- 2020
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114. IRIDE White Book, An Interdisciplinary Research Infrastructure based on Dual Electron linacs&lasers
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Alesini, D., Alessandroni, M., Anania, M. P., Andreas, S., Angelone, M., Arcovito, A., Arnesano, F., Artioli, M., Avaldi, L., Babusci, D., Bacci, A., Balerna, A., Bartalucci, S., Bedogni, R., Bellaveglia, M., Bencivenga, F., Benfatto, M., Biedron, S., Bocci, V., Bolognesi, M., Bolognesi, P., Boni, R., Bonifacio, R., Boscolo, M., Boscherini, F., Bossi, F., Broggi, F., Buonomo, B., Calo', V., Catone, D., Capogni, M., Capone, M., Castellano, M., Castoldi, A., Catani, L., Cavoto, G., Cherubini, N., Chirico, G., Cestelli-Guidi, M., Chiadroni, E., Chiarella, V., Cianchi, A., Cianci, M., Cimino, R., Ciocci, F., Clozza, A., Collini, M., Colo', G., Compagno, A., Contini, G., Coreno, M., Cucini, R., Curceanu, C., Dabagov, S., Dainese, E., Davoli, I., Dattoli, G., De Caro, L., De Felice, P., Della Longa, S., Monache, G. Delle, De Spirito, M., Di Cicco, A., Di Donato, C., Di Gioacchino, D., Di Giovenale, D., Di Palma, E., Di Pirro, G., Dodaro, A., Doria, A., Dosselli, U., Drago, A., Escribano, R., Esposito, A., Faccini, R., Ferrari, A., Ferrario, M., Filabozzi, A., Filippetto, D., Fiori, F., Frasciello, O., Fulgentini, L., Gallerano, G. P., Gallo, A., Gambaccini, M., Gatti, C., Gatti, G., Gauzzi, P., Ghigo, A., Ghiringhelli, G., Giannessi, L., Giardina, G., Giannini, C., Giorgianni, F., Giovenale, E., Gizzi, L., Guaraldo, C., Guazzoni, C., Gunnella, R., Hatada, K., Ivashyn, S., Jegerlehner, F., Keeffe, P. O., Kluge, W., Kupsc, A., Iannone, M., Labate, L., Sandri, P. Levi, Lombardi, V., Londrillo, P., Loreti, S., Losacco, M., Lupi, S., Macchi, A., Magazu', S., Mandaglio, G., Marcelli, A., Margutti, G., Mariani, C., Mariani, P., Marzo, G., Masciovecchio, C., Masjuan, P., Mattioli, M., Mazzitelli, G., Merenkov, N. P., Michelato, P., Migliardo, F., Migliorati, M., Milardi, C., Milotti, E., Milton, S., Minicozzi, V., Mobilio, S., Morante, S., Moricciani, D., Mostacci, A., Muccifora, V., Murtas, F., Musumeci, P., Nguyen, F., Orecchini, A., Organtini, G., Ottaviani, P. L., Pace, E., Paci, M., Pagani, C., Pagnutti, S., Palmieri, V., Palumbo, L., Panaccione, G. C., Papadopoulos, C. F., Papi, M., Passera, M., Pasquini, L., Pedio, M., Perrone, A., Petralia, A., Petrillo, C., Petrillo, V., Pillon, M., Pierini, P., Pietropaolo, A., Polosa, A. D., Pompili, R., Portoles, J., Prosperi, T., Quaresima, C., Quintieri, L., Rau, J. V., Reconditi, M., Ricci, A., Ricci, R., Ricciardi, G., Ripiccini, E., Romeo, S., Ronsivalle, C., Rosato, N., Rosenzweig, J. B., Rossi, G., Rossi, A. A., Rossi, A. R., Rossi, F., Russo, D., Sabatucci, A., Sabia, E., Sacchetti, F., Salducco, S., Sannibale, F., Sarri, G., Scopigno, T., Serafini, L., Sertore, D., Shekhovtsova, O., Spassovsky, I., Spadaro, T., Spataro, B., Spinozzi, F., Stecchi, A., Stellato, F., Surrenti, V., Tenore, A., Torre, A., Trentadue, L., Turchini, S., Vaccarezza, C., Vacchi, A., Valente, P., Venanzoni, G., Vescovi, S., Villa, F., Zanotti, G., Zema, N., and Zobov, M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Physics - Accelerator Physics - Abstract
This report describes the scientific aims and potentials as well as the preliminary technical design of IRIDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity 'particle factory', based on a combination of a high duty cycle radio-frequency superconducting electron linac and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of science and technology. IRIDE will contribute to open new avenues of discoveries and to address most important riddles: What does matter consist of? What is the structure of proteins that have a fundamental role in life processes? What can we learn from protein structure to improve the treatment of diseases and to design more efficient drugs? But also how does an electronic chip behave under the effect of radiations? How can the heat flow in a large heat exchanger be optimized? The scientific potential of IRIDE is far reaching and justifies the construction of such a large facility in Italy in synergy with the national research institutes and companies and in the framework of the European and international research. It will impact also on R&D work for ILC, FEL, and will be complementarity to other large scale accelerator projects. IRIDE is also intended to be realized in subsequent stages of development depending on the assigned priorities., Comment: 270 pages
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- 2013
115. Observation of Dirac plasmons in a topological insulator
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Di Pietro, P., Ortolani, M., Limaj, O., Di Gaspare, A., Giliberti, V., Giorgianni, F., Brahlek, M., Bansal, N., Koirala, N., Oh, S., Calvani, P., and Lupi, S.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Plasmons are the quantized collective oscillations of electrons in metals and doped semiconductors. The plasmons of ordinary, massive electrons are since a long time basic ingredients of research in plasmonics and in optical metamaterials. Plasmons of massless Dirac electrons were instead recently observed in a purely two-dimensional electron system (2DEG)like graphene, and their properties are promising for new tunable plasmonic metamaterials in the terahertz and the mid-infrared frequency range. Dirac quasi-particles are known to exist also in the two-dimensional electron gas which forms at the surface of topological insulators due to a strong spin-orbit interaction. Therefore,one may look for their collective excitations by using infrared spectroscopy. Here we first report evidence of plasmonic excitations in a topological insulator (Bi2Se3), that was engineered in thin micro-ribbon arrays of different width W and period 2W to select suitable values of the plasmon wavevector k. Their lineshape was found to be extremely robust vs. temperature between 6 and 300 K, as one may expect for the excitations of topological carriers. Moreover, by changing W and measuring in the terahertz range the plasmonic frequency vP vs. k we could show, without using any fitting parameter, that the dispersion curve is in quantitative agreement with that predicted for Dirac plasmons., Comment: 11 pages, 3 figures, published in Nature Nanotechnology (2013)
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- 2013
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116. Measuring the Effectiveness of Safety Warnings on the Risk of Stroke in Older Antipsychotic Users: A Nationwide Cohort Study in Two Large Electronic Medical Records Databases in the United Kingdom and Italy
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Sultana, Janet, Fontana, Andrea, Giorgianni, Francesco, Tillati, Silvia, Cricelli, Claudio, Pasqua, Alessandro, Patorno, Elisabetta, Ballard, Clive, Sturkenboom, Miriam, and Trifirò, Gianluca
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- 2019
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117. Correction to: Association of the Careggi Collateral Score with 3-month modified Rankin Scale score after thrombectomy for stroke with occlusion of the middle cerebral artery
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Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Fainardi, Enrico, Consoli, Arturo, Nappini, Sergio, Castellan, Lucio, Bracco, Sandra, Bergui, Mauro, Cosottini, Mirco, Vangosa, Alessandra Briatico, Vinci, Sergio, Ruggiero, Maria, Puglielli, Edoardo, Chiumarulo, Luigi, Cester, Giacomo, Comelli, Chiara, Silvagni, Umberto, Morosetti, Daniele, Caldiera, Valentina, Cavasin, Nicola, Ledda, Valeria, Sanfilippo, Giuseppina, Saletti, Andrea, Filauri, Pietro, Gallesio, Ivan, Nuzzi, Nunzio Paolo, Amistá, Pitero, Zivelonghi, Cecilia, Plebani, Mauro, Pavia, Marco, Romano, Daniele, Biraschi, Francesco, Menozzi, Roberto, Gasparotti, Roberto, Giorgianni, Andrea, Zini, Andrea, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salvatore
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- 2022
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118. Impact of a Modular Bridge Course for First-Year Pharmacy Students
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Baggett, Rachael D., Havrda, Dawn E., Shelton, Chasity M., Kodweis, Karl R., and Beranova-Giorgianni, Sarka
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- 2024
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119. Asymmetric Organocatalysis—A Powerful Technology Platform for Academia and Industry: Pregabalin as a Case Study
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Giuliana Giorgianni, Luca Bernardi, Francesco Fini, Fabio Pesciaioli, Francesco Secci, and Armando Carlone
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industry ,process development ,organocatalysis ,pregabalin ,API ,asymmetric catalysis ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
Enantioselective organocatalysis has quickly established itself as the third pillar of asymmetric catalysis. It is a powerful technology platform, and it has a tremendous impact in both academic and industrial settings. By focusing on pregabalin, as a case study, this Perspective aims to show how a process amenable to industry of a simple chiral molecule can be tackled in several different ways using organocatalysis.
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- 2022
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120. Data-independent proteome analysis of ARPE-19 cells
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Diwa Koirala, Sarka Beranova-Giorgianni, and Francesco Giorgianni
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
We have performed a proteomics analysis of a human retinal pigment epithelial cell line (ARPE-19), which represents a widely used model for in vitro studies of cellular and molecular mechanisms related to human RPE cells (Dunn et al., 1996; Weigel et al., 2002) [1,2]. Whole cell protein extracts were separated in four gel fractions via short (10 min) SDS-PAGE runs. Following fractionation and trypsin digestion, the resulting peptides were separated on a nano UPLC LC system and analyzed on-line with a QTof-IMS instrument: a tandem mass spectrometer with ion mobility separation (Synapt G2-Si). Data were acquired in data-independent mode (UDMSE), which allows for absolute and/or relative post-acquisition protein quantification (Silva et al., 2006) [3]. The proteome profile data obtained from this study can be used as a protein reference database with qualitative and quantitative protein information related to ARPE-19 cells under normal growth conditions.
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- 2018
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121. IRIDE: Interdisciplinary research infrastructure based on dual electron linacs and lasers
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Ferrario, M, Alesini, D, Alessandroni, M, Anania, MP, Andreas, S, Angelone, M, Arcovito, A, Arnesano, F, Artioli, M, Avaldi, L, Babusci, D, Bacci, A, Balerna, A, Bartalucci, S, Bedogni, R, Bellaveglia, M, Bencivenga, F, Benfatto, M, Biedron, S, Bocci, V, Bolognesi, M, Bolognesi, P, Boni, R, Bonifacio, R, Boscherini, F, Boscolo, M, Bossi, F, Broggi, F, Buonomo, B, Calo, V, Catone, D, Capogni, M, Capone, M, Cassou, K, Castellano, M, Castoldi, A, Catani, L, Cavoto, G, Cherubini, N, Chirico, G, Cestelli-Guidi, M, Chiadroni, E, Chiarella, V, Cianchi, A, Cianci, M, Cimino, R, Ciocci, F, Clozza, A, Collini, M, Colo, G, Compagno, A, Contini, G, Coreno, M, Cucini, R, Curceanu, C, Curciarello, F, Dabagov, S, Dainese, E, Davoli, I, Dattoli, G, De Caro, L, De Felice, P, De Leo, V, Dell Agnello, S, Della Longa, S, Delle Monache, G, De Spirito, M, Di Cicco, A, Di Donato, C, Di Gioacchino, D, Di Giovenale, D, Di Palma, E, Di Pirro, G, Dodaro, A, Doria, A, Dosselli, U, Drago, A, Dupraz, K, Escribano, R, Esposito, A, Faccini, R, Ferrari, A, Filabozzi, A, Filippetto, D, Fiori, F, Frasciello, O, Fulgentini, L, Gallerano, GP, Gallo, A, Gambaccini, M, Gatti, C, Gatti, G, Gauzzi, P, Ghigo, A, Ghiringhelli, G, Giannessi, L, Giardina, G, Giannini, C, Giorgianni, F, and Giovenale, E
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SC Linac ,FEL ,Particle physics ,Neutron source ,Compton source ,Advanced accelerators concepts ,physics.ins-det ,hep-ex ,physics.acc-ph ,Nuclear & Particles Physics ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Other Physical Sciences ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics - Abstract
This paper describes the scientific aims and potentials as well as the preliminary technical design of IRIDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity "particles factory", based on a combination of high duty cycle radio-frequency superconducting electron linacs and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of science and technology. IRIDE is also supposed to be realized in subsequent stages of development depending on the assigned priorities. © 2013 Elsevier B.V.
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- 2014
122. The Conversion of 5-Chloromethylfurfural into 5- Methoxymethylfurfural via Nucleophilic Substitution: Kinetic Modeling.
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Giorgianni, Gianfranco, van Putten, Rober-Jan, Van der Waal, Jan C., Perathoner, Siglinda, Centi, Gabriele, and Abate, Salvatore
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FURFURAL ,NUCLEOPHILIC substitution reactions ,CHEMICAL kinetics ,METHANOL ,CARBOXYLIC acids - Abstract
The nucleophilic substitution of chlorine into the 5-chloromethylfurfural (CMF) by methanol is a high potential route for the production of 5-methoxymethylfurfural (MMF), allowing the production of 2,5-furandicarboxylic acid, an important intermediate for polyester synthesis with larger yield and selectivity than 5-hydroxymethylfurfural. However, HCl, produced during the nucleophilic substitution, leads to the formation of by-products like humins or methyl levulinate, and it is faced by adding bases to the reaction with the side effect of producing large amounts of waste as salts. On the contrary, optimizing the MMF yields in the absence of any base could allow the recycling of the produced HCl into the CMF production process, with benefits for the whole route. To optimize the reaction, CMF was reacted with methanol at low concentration, using a multi-reactor in batch mode, to maximize the MMF yield at 10, 20, 40, and 50 °C. Finally, a lumped kinetic model was employed to analyse the reaction further. The yield of MMF and its corresponding acetal increase with a reaction time and temperature of up to 60 % in 1.5 h. [ABSTRACT FROM AUTHOR]
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- 2024
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123. Evaluating the comparability of osteoporosis treatments using propensity score and negative control outcome methods in UK and Denmark electronic health record databases
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Rathod-Mistry, Trishna, primary, Tan, Eng Hooi, additional, Strauss, Victoria Y, additional, O’Kelly, James, additional, Giorgianni, Francesco, additional, Baxter, Richard, additional, Brunetti, Vanessa C, additional, Pedersen, Alma Becic, additional, Ehrenstein, Vera, additional, and Prieto-Alhambra, Daniel, additional
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- 2023
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124. Acetaldehyde in the Enders triple cascade reaction via acetaldehyde dimethyl acetal
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Brusa, Alessandro, primary, Iapadre, Debora, additional, Casacchia, Maria Edith, additional, Carioscia, Alessio, additional, Giorgianni, Giuliana, additional, Magagnano, Giandomenico, additional, Pesciaioli, Fabio, additional, and Carlone, Armando, additional
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- 2023
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125. Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5
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Shukla, Pradeep K., primary, Rao, Roshan G., additional, Meena, Avtar S., additional, Giorgianni, Francesco, additional, Lee, Sue Chin, additional, Raju, Preeti, additional, Shashikanth, Nitesh, additional, Shekhar, Chandra, additional, Beranova, Sarka, additional, Balazs, Louisa, additional, Tigyi, Gabor, additional, Gosain, Ankush, additional, and Rao, RadhaKrishna, additional
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- 2023
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126. In search of potential predictors of erythropoiesis-stimulating agents (ESAs) hyporesponsiveness: a population-based study
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Ylenia Ingrasciotta, Viviana Lacava, Ilaria Marcianò, Francesco Giorgianni, Giovanni Tripepi, Graziella D’ Arrigo, Alessandro Chinellato, Daniele Ugo Tari, Domenico Santoro, and Gianluca Trifirò
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Hyporesponsiveness ,Erythropoiesis-stimulating agents ,Prediction ,Claims database ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Evidences show that around 20% of biosimilar or originator erythropoiesis-stimulating agents (ESAs) users are hyporesponsive. Controversial post-marketing data exist on the predictors of ESA hyporesponsiveness. The aim of this study was to identify predictors of ESA hyporesponsiveness in patients with chronic kidney disease (CKD) or cancer in clinical practice. Methods During the years 2009–2015, a multi-center, population-based, cohort study was conducted using claims databases of Treviso and Caserta Local Health Units (LHUs). All incident ESA users were characterized at baseline and the differences between the baseline hemoglobin (Hb) value, that is the Hb registered within 30 days prior to the first ESA dispensing (index date, ID) and each outcome Hb value (registered between 30 and 180 days after ID) were calculated and defined as delta Hb (ΔHb). Incident ESA users were defined as hyporesponsive if, during follow-up, they registered at least one ΔHb
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- 2019
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127. Overcoming the thermal regime for the electric-field driven Mott transition in vanadium sesquioxide
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Flavio Giorgianni, Joe Sakai, and Stefano Lupi
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Science - Abstract
Thermal effects limit the speed of the electrically driven insulator-metal transition in V2O3 to tens of picoseconds. Here the authors show that under an intense THz-electric-field excitation the thermal regime can be overcome, achieving a purely electronic transition on ultrafast timescales.
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- 2019
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128. High frequency of empty sella, with gender differences, in the early neuroradiology evaluation of patients with traumatic brain injury. A prospective study
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Fausto Fama', Roberto Vita, Alessandro Sindoni, Sergio Lucio Vinci, Grazia Giorgianni, Loredana Grasso, Maria Gioffre'-Florio, and Salvatore Benvenga
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
One-hundred four persons aged ≥ 18 years (62 males and 42 females) who were admitted for traumatic brain injury (TBI) underwent brain computed tomography (CT) scan and assay of serum cortisol, insulin-like growth factor 1 (IGF-1), thyrotropin (TSH) and free thyroxine (FT4). The main purpose was to assess any gender difference and the rate of empty sella (ES).Women were more likely to have empty sella (19/42 [45.2%] vs 19/62 [30.6%], P = 0.15, OR = 1.9), which was more frequently total ES or TES (16/19 [84.2%] vs 3/19 [15.8%], P = 0.0025, OR = 11.6). Neuroradiology was normal in the remaining 65 patients. Patients with TES were approximately 20–30 years older than both patients with partial ES (PES) and normal sella, but only the comparison with normal sella was significant (P = 0.001 all patients, P = 0.005 males). Presumed deficiency of IGF-1, cortisol or TSH occurred in 33 persons (31.7%; 20 Males [32.2%], 13 Females [30.9%]), 14 (13.5%; 10 M [16.2%], 4F [9.5%]) or 8 (7.7%; 1 M [1.7%], 7F [16.7%]), with only TSH deficiency having significant intergender difference (P = 0.007). The highest or lowest rates of IGF-1 deficiency occurred in men with PES (41.7%) or men with TES (14.3%), of cortisol deficiency in men with PES (33.3%) or women with PES (zero), and TSH deficiency in women with TES (18.7%) or both men and women with PES (zero) and men with normal sella (zero). Within ES, males with no deficiency were older compared to males with at least one hormone deficiency (75.7 ± 17.4 vs 55.6 ± 18.9, P = 0.022); in turn, the former males were also older compared with normal sella males having no hormone deficiency (54.1 ± 25.2, P = 0.023).In conclusion, ES is detectable in almost 40% of persons who undergo CT within 24 h from TBI. A number of intergender differences concerning ES and the hormones evaluated are apparent. Keywords: Traumatic brain injury, Post-traumatic hypopituitarism, Empty sella, Computed tomography
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- 2019
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129. Patterns and trends of utilization of incretin-based medicines between 2008 and 2014 in three Italian geographic areas
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Giuseppe Roberto, Francesco Barone-Adesi, Francesco Giorgianni, Valeria Pizzimenti, Carmen Ferrajolo, Michele Tari, Claudia Bartolini, Roberto Da Cas, Marina Maggini, Stefania Spila-Alegiani, Paolo Francesconi, Gianluca Trifirò, Elisabetta Poluzzi, Fabio Baccetti, and Rosa Gini
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Glucagon-like peptide-1 analogues ,Dipeptidyl peptidase-4 inhibitors ,Drug utilization ,Database network ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs possess comparable efficacy and low risk of hypoglycaemia, differences in terms of route of administration (subcutaneous versus oral), effect on body weight and gastrointestinal tolerabily can impact their actual use in clinical practice. This study aimed to describe the real-world utilization of incretin-based medicines in the Italian clinical practice. Methods A multi-database, population-based, descriptive, cohort study was performed using administrative data collected between 2008 and 2014 from three Italian geographic areas. Subjects aged ≥18 were selected. New users were defined as those with ≥1 dispensing of GLP1a or DPP4i during the year of interest and none in the past. Trends of cumulative annual incidence of use in the general adult population were observed. New users of GLP1a or DPP4i were respectively described in terms of demographic characteristics and use of antidiabetic drugs during 1 year before and after the first incretin dispensing. Results The overall study population included 4,943,952 subjects. A total of 7357 new users of GLP1a and 41,907 of DPP4i were identified during the study period. Incidence of use increased between 2008 (0.2‰ for both GLP1a and DPP4i) and 2011 (GLP1a = 0.6‰; DPP4i = 2.5‰) and slightly decreased thereafter. In 2014, 61% of new GLP1a users received once-daily liraglutide while 52% of new DPP4i users received metformin/DPP4i in fixed-dose. The percentage of new DPP4i users older than 65 years of age increased from 30.9 to 62.6% during the study period. Around 12% of new users had not received any antidiabetic before starting an incretin. Conclusions During the study period, DPP4i rapidly became the most prescribed incretin-based medicine, particularly among older new user. The choice of the specific incretin-based medicine at first prescription appeared to be directed towards those with higher convenience of use (e.g. oral DPP4i rather than subcutaneous GLP1a, once-daily liraglutide rather than twice-daily exenatide). The non-negligibile use of incretin-based medicines as first-line pharmacotherapy for T2DM warrants further effectiveness and safety evaluations to better define their place in therapy.
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- 2019
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130. Steam Reforming of Bioethanol Using Metallic Catalysts on Zeolitic Supports: An Overview
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Francesco Dalena, Emanuele Giglio, Alessia Marino, Alfredo Aloise, Gianfranco Giorgianni, Massimo Migliori, and Girolamo Giordano
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bioethanol ,steam reforming ,hydrogen ,zeolite ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
Hydrogen is considered one of the energy carriers of the future due to its high mass-based calorific value. Hydrogen combustion generates only water, and it can be used directly as a fuel for electricity/heat generation. Nowadays, about 95% of the hydrogen is produced via conversion of fossil fuels. One of the future challenges is to find processes based on a renewable source to produce hydrogen in a sustainable way. Bioethanol is a promising candidate, since it can be obtained from the fermentation of biomasses, and easily converted into hydrogen via steam catalytic reforming. The correct design of catalysts and catalytic supports plays a crucial role in the optimization of this reaction. The best results have to date been achieved by noble metals, but their high costs make them unsuitable for industrial application. Very satisfactory results have also been achieved by using nickel and cobalt as active metals. Furthermore, it has been found that the support physical and chemical properties strongly affect the catalytic performance. In this review, zeolitic materials used for the ethanol steam reforming reaction are overviewed. We discuss thermodynamics, reaction mechanisms and the role of active metal, as well as the main noble and non-noble active compounds involved in ethanol steam reforming reaction. Finally, an overview of the zeolitic supports reported in the literature that can be profitably used to produce hydrogen through ethanol steam reforming is presented.
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- 2022
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131. Mental health
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Giorgianni, Salvatore J., primary, Brott, Armin, additional, Milstein, Susan A., additional, and Karczmarczyk, Diana, additional
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- 2020
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132. Case–control study on intestinal intussusception: implications for anti-rotavirus vaccination
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Vincenzo Restivo, Claudio Costantino, Gabriele Giorgianni, Mario Cuccia, Fabio Tramuto, Giovanni Corsello, Alessandra Casuccio, and Francesco Vitale
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antibiotic use ,anti-rotavirus vaccine ,breastfeeding ,gastroenteritis ,intussusception ,risk factor ,Internal medicine ,RC31-1245 - Abstract
Background: Intussusception represents the most common cause of abdominal emergency among young children but nearly 75% of cases are still considered idiopathic. Research design and methods: A case–control study was conducted among Sicilian children aged 0–59 months with a hospital admission for intussusception between 2009 and 2015 to identify factors associated with intussusception onset. Results: Overall, 125 cases and 190 controls were recruited for the study. Birth order (OR 1.49, 95%CI: 1.10, 2.02, P = 0.02) and having had gastroenteritis or having taken antibiotics during the 30 days prior to hospitalization (OR 11.55, 95%CI: 3.23, 41.23, P
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- 2018
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133. Spontaneous coronary artery dissection: an unpredictable event
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Alexandra Smirnova, Flaminia Aliberti, Claudia Cavaliere, Ilaria Gatti, Viviana Vilardo, Carmelina Giorgianni, Chiara Cassani, Alessandra Repetto, Nupoor Narula, Lorenzo Giuliani, Mario Urtis, Yukio Ozaki, Francesco Prati, Eloisa Arbustini, and Michela Ferrari
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Cardiology and Cardiovascular Medicine - Abstract
Spontaneous coronary artery dissection (SCAD) is an under-recognized cause of acute coronary syndrome that predominantly affects women in adulthood and is the leading cause of acute myocardial infarction in pregnancy. The most common clinical presentation is ST-segment elevation myocardial infarction (STEMI) or non-STEMI, followed by cardiogenic shock (∼2%), sudden cardiac death (0.8% in autopsy series), cardiac arrest, ventricular arrhythmias (∼5%), and Takotsubo syndrome. The prevalence of SCAD in the general population is largely uncertain due to underdiagnosis. Oral contraceptives, post-menopausal therapy, and infertility treatments are recognized associated factors. The pathological substrates (fibromuscular dysplasia) and triggers (especially emotional stress) are commonly present in affected women. The few cases with a precise genetic aetiology occur in the context of syndromic and non-syndromic connective tissue diseases. The only true certainty in SCAD is the overwhelming prevalence in women. The first event as well as the recurrence (up to 30%, which varies depending on the definition) is largely unpredictable. The treatment strategy is highly individualized and requires extensive additional study in order to optimize outcomes and prevent major adverse cardiovascular events in affected individuals. We have known about SCAD for nearly a century, but we still do not know how best to prevent, diagnose, and treat it, making SCAD a highly important and unmet clinical need.
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- 2023
134. Dme Production via Methanol Dehydration with H Form and Desilicated Zsm-5 Type Zeolitic Catalysts: Study on the Correlation Between Acid Sites and Conversion
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Francesco Dalena, Emanuele Giglio, Gianfranco Giorgianni, Daniela Cozza, Alessia Marino, and Alfredo Aloise
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Chemical engineering ,TP155-156 ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
Methanol (MeOH) dehydration for Dimethyl ether (DME) production is one of the possible pathways to produce a green, synthetic fuel that can substitute fossil/conventional ones in automotive/transportation applications. DME synthesis in gas phase usually occurs in presence of an acid catalyst at moderate temperature (up to 250 °C). This work deals with the use of MFI-type zeolitic catalysts. H form and desilicated zeolite samples were synthesized, characterized, and tested to investigate their catalytic activity in MeOH dehydration reaction. Ammonia temperature-programmed desorption (NH3-TPD) and Fourier-transform Infrared spectroscopy (FT-IR) analyses were carried out to elucidate the amount and the nature of acid sites. Zeolite sample desilicated for 60 minutes presented a higher amount of Bronsted acid sites (that can be correlated to the superior catalytic activity), while the Turnover frequency (TOF) referred to the amount of Bronsted acid sites is very similar for the investigated samples. Finally, preliminary kinetic investigation via linear fitting of experimental data on the Arrhenius plot was carried out for simple first and second order kinetic models.
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- 2021
135. Direct Synthesis of H2o2 on Pd/al2o3 Contactors: Understanding the Effect of Pd Particle Size and Calcination Through Kinetic Analysis
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Gianfranco Giorgianni, Daniela Cozza, Francesco Dalena, Emanuele Giglio, and Salvatore Abate
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Chemical engineering ,TP155-156 ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
The direct synthesis of H2O2 on Pd-based catalysts, although recognized as a potential route for the sustainable production of H2O2, is still limited by the low catalytic selectivity and safety concerns. Here, the calcination treatment effect, with the dispersion of Pd NPs and its interaction with Al2O3, is investigated. Catalysts have been prepared by the sol-immobilization procedure (SI) on Al2O3 as asymmetric alumina membranes (AAS) and tested in both reduced and calcined form (450°C, 1°C/min, 8 h) for the direct synthesis of H2O2. Finally, the catalytic performance was compared with other catalysts, prepared by hydrazine-reduction (NRC) and impregnation-decomposition (IDC) already reported in a previous paper and calcined for a shorter time (450°C, 1°C/min, 6 h). TEM micrographs showed the formation of Pd NPs with average diameters of 12 (NR), 3.8 (IDC), and 3.3 nm (SI), respectively. The reduced SI catalyst has shown a 2-4% selectivity. However, after calcination (SIC), a 69 % selectivity to H2O2 was reached. Compared with NRC and IDC catalysts, the selectivity increased within the series NRC < IDC < SIC. The kinetic analysis of calcined catalysts showed an overall decrease of the hydrogenolysis and direct combustion routes in the series NRC > IDC > SIC. The SIC catalyst's improved performance was related to the increased interaction with the support, stabilizing Pd in its oxidized form.
- Published
- 2021
136. Posterior reversible encephalopathy syndrome and COVID-19: A series of 6 cases from Lombardy, Italy
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Antonio Colombo, Filippo Martinelli Boneschi, Sandro Beretta, Nereo Bresolin, Maurizio Versino, Lorenzo Lorusso, Diego Spagnoli, Giulia Nastasi, Davide Vallauri, Stefania Rota, Maria Repaci, Massimo Ferrarini, Mattia Pozzato, Lucia Princiotta Cariddi, Payam Tabaee Damavandi, Federico Carimati, Paola Banfi, Alessandro Clemenzi, Margherita Marelli, Andrea Giorgianni, Gabriele Vinacci, Marco Mauri, Paola Melzi, Maria Di Stefano, Antonio Tetto, Margherita Canesi, and Andrea Salmaggi
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COVID-19 ,PRES ,Seizures ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Posterior reversible encephalopathy cases are increasingly being reported in patients affected by COVID-19, but the largest series so far only includes 4 patients. We present a series of 6 patients diagnosed with PRES during COVID-19 hospitalized in 5 Centers in Lombardia, Italy. 5 out of the 6 patients required intensive care assistence and seizures developed at weaning from assisted ventilation. 3 out of 6 patients underwent cerebrospinal fluid analysis which was normal in all cases, with negative PCR for Sars-CoV-2 genome search. PRES occurrence may be less rare than supposed in COVID-19 patients and a high suspicion index is warranted for prompt diagnosis and treatment.
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- 2021
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137. Transient acute-onset tetraparesis in a COVID-19 patient
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Giorgianni, Andrea, Vinacci, Gabriele, Agosti, Edoardo, Cariddi, Lucia Princiotta, Mauri, Marco, Baruzzi, Fabio, and Versino, Maurizio
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- 2020
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138. Endovascular Treatment of Acute Basilar Artery Occlusion: Registro Endovascolare Lombardo Occlusione Basilar Artery (RELOBA) Study Group Experience
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Giorgianni, Andrea, Biraschi, Francesco, Piano, Mariangela, Mardighian, Dikran, Gasparotti, Roberto, Frigerio, Michele, Pero, Guglielmo, Quilici, Luca, Crispino, Mario, Pellegrino, Carlo, Pavia, Marco, Peroni, Roberto, Longoni, Marco, Cellerini, Martino, Lafe, Elvis, Remida, Paolo, Faragò, Giuseppe, Reganati, Paolo, Strocchi, Sabina, and Valvassori, Luca
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- 2018
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139. Line-by-line spectroscopic parameters of HFC-32 ro-vibrational transitions within the atmospheric window around 8.2 μm
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Tasinato, Nicola, Ceselin, Giorgia, Pietropolli Charmet, Andrea, Stoppa, Paolo, and Giorgianni, Santi
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- 2018
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140. High performance of Au/ZTC based catalysts for the selective oxidation of bio-derivative furfural to 2-furoic acid11 This paper in honor of Professor James G. Goodwin, Jr., in the occasion of his 75th birthday, to celebrate his outstanding contribution to catalysis sciences and technology.
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Georgia Papanikolaou, Paola Lanzafame, Siglinda Perathoner, Gabriele Centi, Daniela Cozza, Gianfranco Giorgianni, Massimo Migliori, and Girolamo Giordano
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Zeolite template carbon replica ,Selective oxidation ,Furfural catalytic upgrading ,2-furoic synthesis ,Biomass waste valorisation ,Chemistry ,QD1-999 - Abstract
Furfural is a platform bio-molecule for which is valuable to develop new green upgrading processes in biorefinery. We report here for the first time the high performance of Au/ZTC catalyst for the selective oxidation of furfural to 2-furoic acid, as first step to develop electrodes. The ordered nanostructure and high surface area of BEA structure replica ZTC allows to develop 3D-type electrodes. Au/ZTC catalyst shows higher performance than commercial Vulcan, used as reference conductive carbon in fuel cells. The weak acidity on ZTC avoids decarboxylation and esterification reactions, leading to about 90% of furfural conversion fully selectivity to 2-furoic acid.
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- 2021
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141. Screening and treatment of familial hypercholesterolemia in a French sample of ambulatory care patients: A retrospective longitudinal cohort study
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Jean Ferrières, Victoria Banks, Demetris Pillas, Francesco Giorgianni, Laurene Gantzer, Beranger Lekens, Lea Ricci, Margaux Dova-Boivin, Jean-Vannak Chauny, Guillermo Villa, and Gaelle Désaméricq
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Medicine ,Science - Abstract
Background and aims Untreated Familial Hypercholesterolemia (FH) leads to premature morbidity and mortality. In France, its epidemiology and management are understudied in ambulatory care. We described the clinical profile, pharmacological management, and clinical outcomes in a French sample of FH patients. Methods This was a retrospective longitudinal study on patients from The Health Improvement Network (THIN®) database in France, between October 2016-June 2019. Patients ≥18 years, with probable/definite FH based on the Dutch Lipid Clinic Network (DLCN) criteria were included. Baseline characteristics, lipid profile, lipid-lowering therapy (LLT), low-density lipoprotein-cholesterol (LDL-C) goal achievement; and disease management at 6-month of follow-up were analyzed. Results 116 patients with probable (n = 70)/definite (n = 46) FH were included (mean age:57.8±14.0 years; 56.0% women; 9.5% with personal history of cardiovascular events); 90 patients had data available at follow-up. At baseline, 77.6% of patients had LDL-C>190 mg/dL, 27.6% were not receiving LLTs, 37.9% received statins alone, 20.7% statins with other LLTs, and 7.7% other LLTs. High-intensity statins were prescribed to 11.2% of patients, 30.2% received moderate-intensity statins, and 8.6% low-intensity statins. Only 6.0% of patients achieved LDL-C goal. At 6-month of follow-up, statins discontinuation and switching were 22.7% and 2.3%, respectively. None of the patients received proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors at baseline nor follow-up. Conclusions Despite the existence of effective LLTs, FH patients are suboptimally-treated, do not achieve LDL-C goal, and exhibit worsened pharmacological management over time. Future studies with longer follow-up periods and assessment of factors affecting LDL-C management, including lifestyle and diet, are needed.
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- 2021
142. Identifying Faked Responses in Questionnaires with Self-Attention-Based Autoencoders.
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Alberto Purpura, Giuseppe Sartori, Dora Giorgianni, Graziella Orrù, and Gian Antonio Susto
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- 2022
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143. Antipsychotic utilization patterns among patients with schizophrenic disorder: a cross-national analysis in four countries
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Sultana, Janet, Hurtado, Isabel, Bejarano-Quisoboni, Daniel, Giorgianni, Francesco, Huybrechts, Krista F., Lu, Zhigang, Patorno, Elisabetta, Sanfélix-Gimeno, Gabriel, Tari, Daniele Ugo, and Trifirò, Gianluca
- Published
- 2019
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144. Leggett mode controlled by light pulses
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Giorgianni, Flavio, Cea, Tommaso, Vicario, Carlo, Hauri, Christoph P., Withanage, Wenura K., Xi, Xiaoxing, and Benfatto, Lara
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- 2019
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145. Comparison and Functional Genetic Analysis of Striatal Protein Expression Among Diverse Inbred Mouse Strains
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Cory Parks, Francesco Giorgianni, Byron C. Jones, Sarka Beranova-Giorgianni, Bob M. Moore II, and Megan K. Mulligan
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C57BL/6J ,DBA/2J ,striatum ,synaptosome ,proteomics ,systems genetics ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
C57BL/6J (B6) and DBA/2J (D2) inbred mouse strains are highly variable genetically and differ in a large number of behavioral traits related to striatal function, including depression, anxiety, stress response, and response to drugs of abuse. The genetic basis of these phenotypic differences are, however, unknown. Here, we present a comparison of the striatal proteome between B6 and D2 and relate differences at the protein level to strain differences at the mRNA level. We also leverage a recombinant inbred BXD population derived from B6 and D2 strains to investigate the role of genetic variation on the regulation of mRNA and protein levels. Finally, we test the hypothesis that differential protein expression contributes to differential behavioral responses between the B6 and D2 strain. We detected the expression of over 2,500 proteins in membrane-enriched protein fractions from B6 and D2 striatum. Of these, 160 proteins demonstrated significant differential expression between B6 and D2 strains at a 10% false discovery level, including COMT, GABRA2, and cannabinoid receptor 1 (CNR1)—key proteins involved in synaptic transmission and behavioral response. Similar to previous reports, there was little overlap between protein and transcript levels (25%). However, the overlap was greater (51%) for proteins demonstrating genetic regulation of cognate gene expression. We also found that striatal proteins with significantly higher or lower relative expression in B6 and D2 were enriched for dopaminergic and glutamatergic synapses and processes involved in synaptic plasticity [e.g., long-term potentiation (LTP) and long-term depression (LTD)]. Finally, we validated higher expression of CNR1 in B6 striatum and demonstrated greater sensitivity of this strain to the locomotor inhibiting effects of the CNR1 agonist, Δ9-tetrahydrocannabinol (THC). Our study is the first comparison of differences in striatal proteins between the B6 and D2 strains and suggests that alterations in the striatal proteome may underlie strain differences in related behaviors, such as drug response. Furthermore, we propose that genetic variants that impact transcript levels are more likely to also exhibit differential expression at the protein level.
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- 2019
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146. CO2-, He- and H2-broadening coefficients of SO2 for ν1 band and ground state transitions for astrophysical applications
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Ceselin, Giorgia, Tasinato, Nicola, Puzzarini, Cristina, Pietropolli Charmet, Andrea, Stoppa, Paolo, and Giorgianni, Santi
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- 2017
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147. Organocatalytic Synthesis of γ-Amino Acid Precursors via Masked Acetaldehyde under Micellar Catalysis
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Fabio Pesciaioli, Armando Carlone, Luisa Giansanti, Giuliana Giorgianni, Maria Edith Casacchia, and Elena Allegritti
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Micellar Catalysis ,Biomaterials ,amino acids ,Green Chemistry ,Aminocatalysis ,Materials Science (miscellaneous) ,Organic Chemistry ,Micellar Catalysis, Aminocatalysis, Asymmetric Synthesis, amino acids, Green Chemistry ,Catalysis ,Asymmetric Synthesis - Abstract
The development of micellar catalysis offers a sustainable alternative to organic solvents, and represents an environmental milestone in organic synthesis. Here, the first Michael addition of masked acetaldehyde under neutral, cationic and anionic micellar catalysis is reported, affording the products in high yields and enantiomeric excess, despite the use of water as solvent.
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- 2022
148. An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era
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Elisa Candeloro, Federico Carimati, Payam Tabaee Damavandi, Lucia Princiotta Cariddi, Paola Banfi, Alessandro Clemenzi, Marco Gallazzi, Marco Mauri, Valentina Rebecchi, Fabio Baruzzi, Andrea Giorgianni, Matteo Tozzi, Massimo Bianchi, Walter Ageno, and Maurizio Versino
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stroke unit ,reshaping ,hub and spoke system ,COVID-19 pandemic ,timing ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
During the COVID-19 outbreak, the Neurology and Stroke Unit (SU) of the hospital of Varese had to serve as a cerebrovascular hub, meaning that the referral area for the unit doubled. The number of beds in the SU was increased from 4 to 8. We took advantage of the temporary suspension of the out-patient clinic and reshaped our activity to guarantee the 24/7 availability of recombinant tissue Plasminogen Activator (rtPA) intravenous therapy (IVT) in the SU, and to ensure we were able to admit patients to the SU as soon as they completed endovascular treatment (EVT). In 42 days, 46 stroke patients were admitted to our hospital, and 34.7% of them underwent IVT and/or EVT, which means that we treated 0.38 patients per day; in the baseline period from 2016 to 2018, these same figures had been 23.5% and 0.23, respectively. The mean values of the door-to-first CT/MRI and the door-to-groin puncture, but not of the onset-to-door and the door-to-needle periods were slightly but significantly longer than those observed in the baseline period in 276 patients. On an individual basis, only one patient exceeded the door-to-groin puncture time limit computed from the baseline period by about 10 min. None of the patients had a major complication following the procedures. None of the patients was or became SARS-CoV2 positive. In conclusion, we were able to manage the new hub-and-spoke system safely and without significant delays. The reshaping of the SU was made possible by the significant reduction of out-patient activity. The consequences of this reduction are still unknown but eventually, this emergency will suggest ways to reconsider the management and the allocation of health system resources.
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- 2020
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149. The Crisis in Male Mental Health: A Call to Action
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Demetrius Porche PhD and Salvatore J. Giorgianni PharmD
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Medicine - Published
- 2020
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150. Measles and Pregnancy: Immunity and Immunization—What Can Be Learned from Observing Complications during an Epidemic Year
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Rosalia Ragusa, Armando Platania, Mario Cuccia, Gaetano Zappalà, Gabriele Giorgianni, Placido D’Agati, Maria Alessandra Bellia, and Marina Marranzano
- Subjects
Gynecology and obstetrics ,RG1-991 - Abstract
Measles is a highly contagious airborne disease. Unvaccinated pregnant women are not only at risk of infection but also at risk of severe pregnancy complications. As measles causes a dysregulation of the entire immune system, we describe immunological variations and how immune response mechanisms can lead to adverse pregnancy outcomes. We evaluated data during the measles outbreak reported in the province of Catania, Italy, from May 2017 to June 2018. We controlled hospital discharge records for patients admitted to hospital obstetric wards searching the measles diagnostic code. We have indicated the case as “confirmed” when the IgM was found to be positive with the ELISA method. We registered 843 cases of measles and 51% were females (430 cases). 24 patients between the ages of 17 and 40 had measles while they were pregnant. Adverse pregnancy outcomes included 2 spontaneous abortions, 1 therapeutic abortion, 1 foetal death, and 6 preterm deliveries. Respiratory complications were more prevalent in pregnant women (21%) than in nonpregnant women with measles (9%). 14 health care workers (1.7%) were infected with measles, and none of these had been previously vaccinated. Immune response mechanisms were associated with adverse pregnancy outcomes in women with measles. To reduce the rate of measles complications, gynaecologists should investigate vaccination history and antibody test results in all women of childbearing age. During a measles outbreak, gynaecologists and midwives should be active proponents of vaccination administration and counteract any vaccine hesitancy not only in patients but also among health care workers.
- Published
- 2020
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