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102. Structural and kinetic stability of the burkholderia glumae lipase

Author

Invernizzi, G, Papaleo, E, Grandori, R, De Gioia, L, Lotti, M, DE GIOIA, L, INVERNIZZI, GAETANO, PAPALEO, ELENA, GRANDORI, RITA, DE GIOIA, LUCA, LOTTI, MARINA, Invernizzi, G, Papaleo, E, Grandori, R, De Gioia, L, Lotti, M, DE GIOIA, L, INVERNIZZI, GAETANO, PAPALEO, ELENA, GRANDORI, RITA, DE GIOIA, LUCA, and LOTTI, MARINA

Abstract

Stability is a crucial feature for enzymes employed in biocatalytic processes where they might be exposed to non-natural or even harsh environments. We have studied the behaviour of the lipase from Burkholderia glumae (BGL) by exposing it to challenging experimental conditions and characterizing changes in conformation and activity by a large set of biochemical, biophysical (mainly ESI-mass spectrometry, CD, fluorimetry) and computational methods. We observed that deactivation is not strictly related to structural instability in the assay conditions (temperature, pH, solvents), in fact (i) thermal deactivation precedes denaturation; (ii) acid-induced deactivation arises at higher pH than partial or global protein unfolding; and (iii) activity in most organic solvents decreases at solvent concentrations where conformation is fully retained. In the native protein, calcium is not accessible unless specific flexible loops are displaced, for example, by a temperature increase. Such movements concern the whole calcium-binding pocket and particularly the environment of the coordinating aspartate residue 241. As a consequence of metal depletion the protein unfolds irreversibly and undergoes aggregation. Our results are consistent with local unfolding phenomena causing deactivation and in a complex interplay between the mobility of loop structures and the ability of the protein to retain stabilizing Ca2+. This might suggest that a straightforward structural stabilization by site-directed mutagenesis aimed at increasing the general or local rigidity of the protein could be ineffective in relieving the subtle and elusive molecular effects that induce loss of activity in the “twilight” zone, i.e. under conditions that are mild enough to avoid protein unfolding but sub-optimal for activity. In this scenario, random approaches such as mutagenesis by directed evolution may prove to be more effective.

Published
2010

103. Exophthalmos following mechanical thrombectomy for anterior circulation stroke: A retrospective study and review of literature

Author

Volders, D, Labrie, M, Keezer, M, Poppe, AY, Jacquin, G, Stapf, C, Gioia, L, Deschaintre, Y, Odier, C, Daneault, N, Iancu, D, Raymond, J, Roy, D, and Weill, A

Abstract

Background Anecdotal cases of exophthalmos after acute mechanical thrombectomy have been described. We sought to estimate the incidence in a large cohort of patients with acute anterior circulation stroke treated with mechanical thrombectomy. Secondarily, we aimed to evaluate the underlying mechanism and to differentiate it on imaging from other pathology with similar clinical orbital features.Methods Between November 2016 and November 2018, we performed a retrospective single-center study of 250 patients who underwent anterior circulation mechanical thrombectomy. Development of exophthalmos was independently evaluated by two readers on preprocedure and 24-h postprocedure non-contrast cerebral CT.Results In the mechanical thrombectomy cohort, six individuals (2.4%) developed interval ipsilateral exophthalmos at 24 h. Of these, at least two patients developed clinical symptoms. There was almost perfect agreement between assessments of the two readers (Cohen’s kappa = 0.907 (95% confidence interval: 0.726, 1.000)). In two patients, there was delayed ophthalmic artery filling on digital subtraction angiography. None of the patients had features of a direct carotid-cavernous fistula.Conclusions Exophthalmos is not uncommon after mechanical thrombectomy (2.4%). The underlying mechanism is difficult to confirm, but it is most likely due to orbital ischemia from hypoperfusion or distal emboli.

Published
2024
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104. DFT investigation of the CO2 activation at the active site of the Carbon Monoxide Dehydrogenases

Author

Breglia, R, Greco, C, DE GIOIA, L, Bruschi, M, BREGLIA, RAFFAELLA, GRECO, CLAUDIO, DE GIOIA, LUCA, BRUSCHI, MAURIZIO, Breglia, R, Greco, C, DE GIOIA, L, Bruschi, M, BREGLIA, RAFFAELLA, GRECO, CLAUDIO, DE GIOIA, LUCA, and BRUSCHI, MAURIZIO

Abstract

The sustainable production of chemical fuels from non-petrochemical resources and reduction of greenhouse gas emissions are two of the biggest societal challenges. Clean reduction of CO2 to liquid fuels could potentially provide solutions to both. However, a key requirement for the development of large- scale and sustainable process is the design of efficient and selective catalysts. The Ni-containing carbon monoxide dehydrogenases (Ni-CODHs) are the biological catalysts for the reversible reduction of CO2 to CO. The high catalytic efficiency and the absence of expensive metals in their active site (known as C-cluster), composed by an unusual [Fe3NiS4] structure bounded to an additional Fe atom (Feu), make the Ni-CODHs a very promising target for reverse engineering studies aimed at the design of bioinspired catalysts. Structural and spectroscopic studies on Ni-CODH provided multiple insights into the complex catalytic mechanism of this enzyme. However, further investigations of the stereoelectronic and catalytic properties of the C-cluster are required to better understand the enzyme reactivity. In this context, quantum mechanics calculations have been carried out in the framework of the Density Functional Theory (DFT) on a very large model of the active site (290 atoms) and on a minimal model of the C-cluster (62 atoms). A comparative analysis of results obtained using these two different models has allowed to investigate crucial effects of the protein environment on the stereoelectronic properties of the C-cluster. In particular, CO2 binding to active site have been investigated. Three redox states of the C-cluster, differing by one electron (Cred1, Cint, and Cred2), have been considered. According our results, the substrate binding is most favored when the C-cluster is reduced to the Cred2 state. A subsequent transfer of two electrons from the C-cluster to the ligand is responsible for the CO2 activation. Two stable conformations have been identified as stable i

Published
2016

105. Structure-Activity Studies on Arylamides and Arysulfonamides Ras Inhibitors

Author

Atta-ur-Rahman, Bentham Science Publisher, Colombo, S, Palmioli, A, Airoldi, C, Tisi, R, Fantinato, S, Olivieri, S, De Gioia, L, Martegani, E, Peri, F, Atta-ur-Rahman, Bentham Science Publisher, Colombo, S, Palmioli, A, Airoldi, C, Tisi, R, Fantinato, S, Olivieri, S, De Gioia, L, Martegani, E, and Peri, F

Abstract

This paper reports on the synthesis of a panel of small molecules with arylamides and arylsulfonamides groups and their biological activity in inhibiting nucleotide exchange on human Ras. The design of these molecules was guided by structure-activity data previously collected on similar compounds. Aim of this work is the validation of the hypothesis that a phenyl hydroxylamine group linked to a second aromatic moiety generates a pharmacophore capable to interact with Ras and to inhibit its activation. In vitro experiments on purified human Ras clearly show that the presence of an aromatic hydroxylamine and a sulfonamide group in the same molecule is necessary to Ras binding and nucleotide exchange inhibition. The inhibitor potency is lower in molecules in which either the hydroxylamine has been replaced by other functional groups or the sulfonamide has been replaced by an amide. In this case both these moieties, the hydroxylamine and sulfonamide are absent, inactive compounds are obtained.

Published
2016

106. DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions

Author

Lambrughi, M, DE GIOIA, L, Gervasio, F, Lindorff Larsen, K, Nussinov, R, Urani, C, Bruschi, M, Papaleo, E, LAMBRUGHI, MATTEO, DE GIOIA, LUCA, URANI, CHIARA, BRUSCHI, MAURIZIO, PAPALEO, ELENA, Lambrughi, M, DE GIOIA, L, Gervasio, F, Lindorff Larsen, K, Nussinov, R, Urani, C, Bruschi, M, Papaleo, E, LAMBRUGHI, MATTEO, DE GIOIA, LUCA, URANI, CHIARA, BRUSCHI, MAURIZIO, and PAPALEO, ELENA

Abstract

Binding-induced conformational changes of a protein at regions distant from the binding site may play crucial roles in protein function and regulation. The p53 tumour suppressor is an example of such an allosterically regulated protein. Little is known, however, about how DNA binding can affect distal sites for transcription factors. Furthermore, the molecular details of how a local perturbation is transmitted through a protein structure are generally elusive and occur on timescales hard to explore by simulations. Thus, we employed state-of-the-art enhanced sampling atomistic simulations to unveil DNA-induced effects on p53 structure and dynamics that modulate the recruitment of cofactors and the impact of phosphorylation at Ser215. We show that DNA interaction promotes a conformational change in a region 3 nm away from the DNA binding site. Specifically, binding to DNA increases the population of an occluded minor state at this distal site by more than 4-fold, whereas phosphorylation traps the protein in its major state. In the minor conformation, the interface of p53 that binds biological partners related to p53 transcription-independent functions is not accessible. Significantly, our study reveals a mechanism of DNA-mediated protection of p53 from interactions with partners involved in the p53 transcription-independent signalling. This also suggests that conformational dynamics is tightly related to p53 signalling.

Published
2016

107. Computational approaches to the prediction of the redox potentials of iron and copper bioinorganic systems

Author

Bruschi, M, Breglia, R, Arrigoni, F, Fantucci, P, DE GIOIA, L, BRUSCHI, MAURIZIO, BREGLIA, RAFFAELLA, ARRIGONI, FEDERICA, FANTUCCI, PIERCARLO, DE GIOIA, LUCA, Bruschi, M, Breglia, R, Arrigoni, F, Fantucci, P, DE GIOIA, L, BRUSCHI, MAURIZIO, BREGLIA, RAFFAELLA, ARRIGONI, FEDERICA, FANTUCCI, PIERCARLO, and DE GIOIA, LUCA

Abstract

Aim of this contribution is to review some recent quantum mechanical approaches used to compute the redox potentials of transition metal complexes, with the emphasis on copper and iron species, which are particularly relevant in inorganic biochemistry and in synthetic chemistry of bio-mimetic compounds. The paper presents also new DFT results obtained on Cu and Fe aquo ions in the framework of the Thermodynamic Integration and Grand Canonical Ensemble approaches. Such results show that without explicit inclusion of water molecules in the external solvation shells (even using a continuum solvation model) also very advanced methodologies fail to predict the redox potential in an acceptable manner. This is a confirmation of some previous studies which however never addressed this specific problem along the aforementioned approaches. Better results are obtained, on the contrary, on a series of Cu(II) complexes with Gly, Ala, en, Im, and water ligands with coordination type N2O2 or N4. In this case, the complexes are surrounded by nine water molecules which may partially alleviate the inadequacy of the continuum solvent models, especially in the case of highly positively charged species.

Published
2016

108. Reactivity of the Excited States of the H-Cluster of FeFe Hydrogenases

Author

Sensi, M, Baffert, C, Greco, C, Caserta, G, Gauquelin, C, Saujet, L, Fontecave, M, Roy, S, Artero, V, Soucaille, P, Meynial Salles, I, Bottin, H, DE GIOIA, L, Fourmond, V, Léger, C, Bertini, L, SENSI, MATTEO, GRECO, CLAUDIO, DE GIOIA, LUCA, BERTINI, LUCA, Sensi, M, Baffert, C, Greco, C, Caserta, G, Gauquelin, C, Saujet, L, Fontecave, M, Roy, S, Artero, V, Soucaille, P, Meynial Salles, I, Bottin, H, DE GIOIA, L, Fourmond, V, Léger, C, Bertini, L, SENSI, MATTEO, GRECO, CLAUDIO, DE GIOIA, LUCA, and BERTINI, LUCA

Abstract

FeFe hydrogenases catalyze H2 oxidation and formation at an inorganic active site (the "H-cluster"), which consists of a [Fe2(CO)3(CN)2(dithiomethylamine)] subcluster covalently attached to a Fe4S4 subcluster. This active site is photosensitive: visible light has been shown to induce the release of exogenous CO (a reversible inhibitor of the enzyme), shuffle the intrinsic CO ligands, and even destroy the H-cluster. These reactions must be understood because they may negatively impact the use of hydrogenase for the photoproduction of H2. Here, we explore in great detail the reactivity of the excited states of the H-cluster under catalytic conditions by examining, both experimentally and using TDDFT calculations, the simplest photochemical reaction: the binding and release of exogenous CO. A simple dyad model can be used to predict which excitations are active. This strategy could be used for probing other aspects of the photoreactivity of the H-cluster.

Published
2016

109. N-Spirofused Bicyclic Derivatives of 1-Deoxynojirimycin: Synthesis and Preliminary Biological Evaluation

Author

D’Orazio, G, Martorana, A, Filippi, G, Polissi, A, De Gioia, L, La Ferla, B, D’Orazio, G, Martorana, A, Filippi, G, Polissi, A, De Gioia, L, and La Ferla, B

Abstract

We synthesized a small library of N-spirofused bicyclic derivatives of 1-deoxynojirimycin (DNJ), as quaternary ammonium salts, through a double SN2 annulation process. The spirofused rings are of different size and structural characteristics. Preliminary biological evaluation showed no antibacterial activity towards both Gram+ and Gram- bacteria. The DNJ derivative bearing a 6 member spirofused cycle revealed a promising inhibitor activity towards amyloglucosidase. Binding energies calculated through docking studies resembled the in vitro capability of such compound and of DNJ to inhibit amyloglucosidase activity, while showing significant difference in the binding poses.

Published
2016

110. The mammalian complement system as an epitome of host-pathogen genetic conflicts

Author

Cagliani, R, Forni, D, Filippi, G, Mozzi, A, De Gioia, L, Pontremoli, C, Pozzoli, U, Bresolin, N, Clerici, M, Sironi, M, Cagliani, R, Forni, D, Filippi, G, Mozzi, A, De Gioia, L, Pontremoli, C, Pozzoli, U, Bresolin, N, Clerici, M, and Sironi, M

Abstract

The complement system is an innate immunity effector mechanism; its action is antagonized by a wide array of pathogens and complement evasion determines the virulence of several infections. We investigated the evolutionary history of the complement system and of bacterial-encoded complement-interacting proteins. Complement components targeted by several pathogens evolved under strong selective pressure in primates, with selection acting on residues at the contact interface with microbial/viral proteins. Positively selected sites in CFH and C4BPA account for the human specificity of gonococcal infection. Bacterial interactors, evolved adaptively as well, with selected sites located at interaction surfaces with primate complement proteins. These results epitomize the expectation under a genetic conflict scenario whereby the host's and the pathogen's genes evolve within binding avoidance-binding seeking dynamics. In silico mutagenesis and protein-protein docking analyses supported this by showing that positively selected sites, both in the host's and in the pathogen's interacting partner, modulate binding.

Published
2016

112. Quantum Chemical Investigations of Reaction Paths of Metalloenzymes and Biomimetic Models – The Hydrogenase Example

Author

Bertini, L, Bruschi, M, De Gioia, L, Fantucci, P, Greco C, Zampella, G, Neese, F, Sinnecker S, Herrmann, C, Reiher, M, Thar, J, Reckien, W, Kirchner, B, Senn, HM, Thiel, W, Dellago, C, Bolhuis, PG, Dittrich, M, Yu, J, Schulten K, DE GIOIA, L, Greco, C, BERTINI, LUCA, BRUSCHI, MAURIZIO, DE GIOIA, LUCA, FANTUCCI, PIERCARLO, GRECO, CLAUDIO, ZAMPELLA, GIUSEPPE, Bertini, L, Bruschi, M, De Gioia, L, Fantucci, P, Greco C, Zampella, G, Neese, F, Sinnecker S, Herrmann, C, Reiher, M, Thar, J, Reckien, W, Kirchner, B, Senn, HM, Thiel, W, Dellago, C, Bolhuis, PG, Dittrich, M, Yu, J, Schulten K, DE GIOIA, L, Greco, C, BERTINI, LUCA, BRUSCHI, MAURIZIO, DE GIOIA, LUCA, FANTUCCI, PIERCARLO, GRECO, CLAUDIO, and ZAMPELLA, GIUSEPPE

Abstract

Quantum chemical methods allow one to investigate chemical aspects that are often difficult to evaluate using only experimental approaches. In particular, the continuous increase in reliability and speed of quantum chemical methods has recently allowed the investigation of very complex molecular systems, such as biological macromolecules. In this contribution, we present applications of quantum chemical methods to the investigation of reaction paths of metalloenzymes and related biomimetic models, using hydrogenase models as a reference case. In particular, we discuss several examples from the literature, emphasizing the possibilities (and limitations) offered by present theoretical approaches to study structures, electronic properties and reactivity of metalloenzyme models. Some relevant aspects which have not yet been fully explored using theoretical methods, such as the role of antiferromagnetic coupling and photochemical reactions in [Fe] hydrogenases, are treated in more detail, with presentation and discussion of original data recently obtained in our laboratory.

Published
2007

113. Density functional theory investigation of guanosine triphosphate models. Catalytic role of Mg2 ions in phosphate ester hydrolysis

Author

Franzini, E, Fantucci, P, De Gioia, L, De Gioia, L., Franzini, E, Fantucci, P, De Gioia, L, and De Gioia, L.

Abstract

Hydrolysis of phosphate ester bonds is a key reaction in biological systems and many enzymes require one or more metal ions as cofactors to catalyse this reaction. However, the exact role of metal ions is still unclear. In this contribution, we have investigated the influence of Mg2 on the hydrolysis of guanosine triphosphate (GTP) models using Density Functional Theory (DFT). Results indicate that Mg2 catalyses phosphate ester hydrolysis, stabilizing the transition state (TS) both for associative and dissociative pathways. In the associative pathway, the reaction is promoted by an increased electrophilicity of the reactive phosphor-us atom, whereas in the dissociative pathway catalysis is achieved by stabilization of beta-phosphate due to Mg2 coordination. Considering relative energy values, it turns out that the dissociative pathway is more favorable. (C) 2003 Elsevier Science B.V. All rights reserved

Published
2003

114. Density functional theory investigation of the active site of [Fe]-hydrogenases: Effects of redox state and ligand characteristics on structural, electronic, and reactivity properties of complexes related to the [2Fe](H) subcluster

Author

Bruschi, M, Fantucci, P, De Gioia, L, De Gioia, L., Bruschi, M, Fantucci, P, De Gioia, L, and De Gioia, L.

Abstract

The effects of redox state and ligand characteristics on structural, electronic, and reactivity properties of complexes related to the [2Fe](H) subcluster of [Fe]-hydrogenases have been investigated by DFT calculations and compared with experimental and theoretical data obtained investigating both the enzyme and synthetic model complexes. Our results show that (FeFeII)-Fe-II species characterized by OH or H2O groups terminally coordinated to the iron atom distal to the terminal sulfur ligand (Fe-d) are less stable than corresponding mu-OH or mu-H2O species, suggesting that the latter are destabilized or kinetically inaccessible in the enzyme. In addition, results obtained investigating (FeFeI)-Fe-I and (FeFeI)-Fe-II complexes show that structure and relative stability of species characterized by a mu-CO group are significantly affected by the electronic properties of the ligands coordinated to the iron atoms. The investigation of reaction pathways for H-2 activation confirms and extends a previous hypothesis indicating that H-2 can be cleaved on (FeFeII)-Fe-II species. In particular, even though [Fe]-hydrogenases are proposed to bind and activate H-2 at a single iron center, the comparison of our data with experimental results obtained studying synthetic complexes (Zhao, X.; Georgakaki, I. P.; Miller, M. L.; Mejia-Rodriguez, R.; Chiang, C.-Y.; Darensbourg, M. Y. Inorg. Chem. 2002, 41, 3917) suggests that activation paths involving both metal ions are also possible. Moreover, p-H (FeFeI)-Fe-II complexes are predicted to correspond to stable species and might be formed in the enzyme catalytic cycle

Published
2003

115. Immunohistochemistry, Immunofluorescence and Confocal Laser Microscopy: an Insight into the Enteric Nervous System During Sheep Infection

Author

DI GUARDO G., MARRUCHELLA G., LIGIOS C., BAFFONI M., CANCEDDA G. M., MACCIOCU S., GIOIA L., DE GROSSI L., AGRIMI U., AGUZZI A., LALATTA COSTERBOSA, GIOVANNA, CHIOCCHETTI, ROBERTO, CLAVENZANI, PAOLO, DI GUARDO G., MARRUCHELLA G., LIGIOS C., BAFFONI M., CANCEDDA G.M., MACCIOCU S., GIOIA L., LALATTA G., CHIOCCHETTI R., CLAVENZANI P., DE GROSSI L., AGRIMI U., and AGUZZI A.

Subjects
sheep, scrapie
Abstract

P03.133 Immunohistochemistry, Immunofluorescence and Confocal Laser Microscopy: An Insight into the Enteric Nervous System During Sheep Scrapie Infection Di Guardo, G1; Marruchella, G1; Ligios, C2; Baffoni, M1; Cancedda, GM2; Macciocu, S2; Gioia, L1; Lalatta Costerbosa, G3; Chiocchetti, R3; Clavenzani, P3; De Grossi, L4; Agrimi, U5; Aguzzi, A6 1Faculty of Veterinary Medicine, University of Teramo, Dept Comparative Biomedical Sciences, Italy; 2Istituto Zooprofilattico Sperimentale della Sardegna, Italy; 3Faculty of Veterinary Medicine, University of Bologna, Dept Vet Morphophysiology and Animal Productions, Italy; 4Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Italy; 5Istituto Superiore di Sanità, Dept Food Safety and Veterinary Public Health, Italy; 6University Hospital of Zurich, Institute of Neuropathology, Switzerland The enteric nervous system (ENS) is likely to play a role in the early pathogenesis of sheep scrapie, but little is known about the ENS cell types involved. We investigated the ileal myenteric plexi (MPs) and submucosal plexi (SMPs) of 4 natural and 4 oral experimental scrapie-affected ARQ/ARQ Sarda breed sheep, as well as of 12 healthy sheep carrying different PRNP genotypes. In all control animals, as well as in all scrapie-affected sheep, which were euthanized at the end stage of clinical disease, detailed laboratory investigations were carried out by means of immunohistochemistry (IHC), as well as by indirect immunofluorescence (IIF) and confocal laser microscopy (CLM) techniques. All the above 8 scrapie-affected animals showed IHC evidence of PrPSc deposition within both MPs and SMPs, with IIF and CLM studies allowing us to identify enteroglial cells (EGCs) and, for the first time, also calbindin (CALB)-immunoreactive (IR) and neuronal nitric oxide synthase (nNOS)-IR neurons as the ENS cytotypes involved in PrPSc accumulation and plausibly, thereby, in the subsequent process of “neuroinvasion”. In conclusion, IHC, IIF and CLM proved to be in our hands three highly valuable and complementary laboratory techniques for investigating the p

Published
2007

116. Immunohistochemistry, Immunofluorescence and Confocal Laser Microscopy: an Insight into the Enteric Nervous System during Sheep Scrapie Infection

Author

Di Guardo G., Marruchella G., Ligios C., Baffoni M., Cancedda G.M., Macciocu S., Gioia L., De Grossi L., Agrimi U., Aguzzi A., LALATTA COSTERBOSA, GIOVANNA, CHIOCCHETTI, ROBERTO, CLAVENZANI, PAOLO, Di Guardo G., Marruchella G., Ligios C., Baffoni M., Cancedda GM., Macciocu S., Gioia L., Lalatta Costerbosa G., Chiocchetti R., Clavenzani P., De Grossi L., Agrimi U., and Aguzzi A.

Published
2007

117. DFT investigation of structural, electronic, and catalytic properties of diiron complexes related to the [2Fe]H subcluster of Fe-only hydrogenases

Author

Bruschi, M, Fantucci, P, De Gioia, L, De Gioia, L., Bruschi, M, Fantucci, P, De Gioia, L, and De Gioia, L.

Abstract

Hydrogenases catalyze the reversible oxidation of dihydrogen to protons and electrons. The structures of two Fe-only hydrogenases have been recently reported [Peters, J. W.; Lanzilotta, W. N.; Lemon, B. J.; Seefeldt, L. C. Science 1998, 282, 1853-1858. Nicolet, Y.; Piras, C.; Legrand, P.; Hatchikian, E. C.; Fontecilla-Camps, J, C. Structure 1999, 7, 13-23], showing that the likely site of dihydrogen activation Is the so-called [2Fe](H) cluster, where each Fe ion is coordinated by CO and CN- ligands and the two metals are bridged by a chelating S-X-3-S ligand. Moreover, the presence of a water molecule coordinated to the distal Fe2 center suggested that the Fe2 atom could be a suitable site for binding and activation of H-2. In this contribution, we report a density functional theory investigation of the structural and electronic properties of complexes derived from the [(CO)(CH3S)(CN)Fe(II)(mu-PDT)Fe(II)(CO)(2)(CN)](-1) species, which is related to the [2Fe]H cluster observed in Fe-only hydrogenases. Our results show that the structure of the [2Fe](H) cluster observed in the enzyme does not correspond to a stable form of the isolated cluster, in the absence of the protein. As a consequence, the reactivity of [(CO)(CH3S)(CN)Fe(II) (mu-PDT)Fe(II)(CO)(2)(CN)](-1) derivatives in solution may be expected to be quite different from that of the active site of Fe-only hydrogenases. In fact, the most favorable path for H-2 activation Involves the two meta[ atoms and one of the bridging S atoms and is associated with a very low activation energy (5.3 kcal mol(-1)). The relevance of these observations for the catalytic properties of Fe-only hydrogenases is discussed in light of available experimental and theoretical data

Published
2002

120. DFT investigation of the Ni-A inactive state of the [NiFe]-hydrogenases: inactivation mechanism under aerobic conditions

Author

Breglia, R, Greco, C, DE GIOIA, L, Bruschi, M, BREGLIA, RAFFAELLA, GRECO, CLAUDIO, DE GIOIA, LUCA, BRUSCHI, MAURIZIO, Breglia, R, Greco, C, DE GIOIA, L, Bruschi, M, BREGLIA, RAFFAELLA, GRECO, CLAUDIO, DE GIOIA, LUCA, and BRUSCHI, MAURIZIO

Abstract

Because dihydrogen is considered as a future non polluting source of energy, Hydrogenase enzymes are of fundamental interest for their capability to catalyse the reversible interconversion of protons and reducing equivalents into molecular hydrogen. While the [FeFe]-hydrogenases are irreversibly inactivated by O2, the oxidized [NiFe]-hydrogenases can be reactivated by one-electron reduction and protonation. This property, in addition to the high catalytic efficiency and the absence of expensive metals in their active site, makes the [NiFe]-hydrogenases a very promising target for reverse engineering studies aimed at the development of bioinspired catalysts. In the active site of [NiFe]-hydrogenases, the iron and nickel atoms are bridged by two cysteine residues. Two further cysteine residues are terminally bounded to the Ni atom while two CN and one CO ligands coordinate the Fe atom. The inactive oxidized Ni-A state of this enzyme have been recently characterized by X-ray diffraction, as containing a bridging hydroxide ligand between the two metallic ions and a bridging cysteine oxidized to its sulfanated form. To investigate the mechanism of oxidation of active forms to this state, quantum mechanics calculations have been carried out in the framework of the Density Functional Theory (DFT) on a very large model of the active site. Under aerobic conditions, oxidation is promoted by binding to the active site of a O2 molecule, that provide the two oxygen atoms included in the Ni-A form.

Published
2015

121. Excited state properties of a [FeFe] hydrogenase active site models. The Time-Dependent Density Functional Theory theoretical picture

Author

Bertini, L, Prosdocimi, T, Arrigoni, F, Filippi, G, DE GIOIA, L, Zampella, G, BERTINI, LUCA, ARRIGONI, FEDERICA, FILIPPI, GIULIA, DE GIOIA, LUCA, ZAMPELLA, GIUSEPPE, Bertini, L, Prosdocimi, T, Arrigoni, F, Filippi, G, DE GIOIA, L, Zampella, G, BERTINI, LUCA, ARRIGONI, FEDERICA, FILIPPI, GIULIA, DE GIOIA, LUCA, and ZAMPELLA, GIUSEPPE

Abstract

Recently a growing interest in the photochemical aspects of [FeFe] hydrogenases catalytic site and their biomimetic models has emerged. The photochemical aspects investigated range from the CO photolysis of the CO inhibited form of the enzyme to the excited state properties of the H-cluster models. [1] Regarding this last point, many efforts have been devoted to the investigation of the photochemical properties of simple diiron models of the [FeFe] hydrogenases catalytic site. The present contribution is focused on the Time-Dependent Density Functional theory (TDDFT) investigation of CO photolysis and photoisomerization of the trimetilphosphine (PMe3) derivative Fe2(S2C2H4)(CO)4(PMe3)2 starting from the recent ultrafast time-resolved infrared spectroscopy measurements [2,3]. By exploring the potential energy surfaces of low energy singlet excited states [4,5] the photoisomerization pathways has been characterized. Our calculation also show that the nature of this mechanism depends on the type of ligands coordinated to the iron atoms. The photoinduced CO dissociation involved excited states at higher excitation energy with the formation of a solvent adduct

Published
2015

125. Surgical treatment of prolactin-secreting pituitary adenomas: Early results and long-term outcome

Author

Losa M, Barzaghi R, Gioia L, Giovanelli M., MORTINI , PIETRO, Losa, M, Mortini, Pietro, Barzaghi, R, Gioia, L, and Giovanelli, M.

Abstract

Medical therapy with dopaminergic drugs is the preferred initial treatment for symptomatic prolactin (PRL)-secreting adenomas; but in recent years, there has been a renewed interest in surgery. The aim of this study is to report a large series of patients operated for prolactinoma in the last 10 yr. A total of 120 consecutive patients (93 female, 27 male) underwent surgery from January 1990 to December 1999. Their mean age at surgery was 29.7 +/- 0.9 yr. Fifty-nine patients (49.2%) had a microadenoma, and the remaining 61 (50.8%) had a macroadenoma, of which 24 (20%) were intrasellar and 37 (30.8%) were extrasellar adenoma. Magnetic resonance imaging signs of invasion of the cavernous sinus were detected in 18 patients (15.0%). Thirty-one patients (25.8%) had never been treated before, whereas the remaining 89 (74.2%) had received dopaminergic drugs. After surgery, normalization of PRL levels occurred in 77 patients (64.2%). Logistic regression analysis showed that the only predictive factor of unsuccessful surgery was a high preoperative PRL level. Recurrence of hyperprolactinemia occurred in 13 of the 77 cured patients (16.9%) during a mean follow-up of 50.2 +/- 3.0 months; the 5-yr disease-free survival was 75.9%. Extrasellar extension of the tumor and presence of a postoperative PRL response to TRH were associated with a lower risk of relapse. In summary, surgery normalized PRL levels and relieved symptoms of hyperprolactinemia in most patients. Recurrence of hyperprolactinemia occurred within 4 yr after surgery. Transsphenoidal surgery can be offered as a definitive therapy, especially to patients with intrasellar tumors.

Published
2002

126. Exression of the chemokine receptor CCR3 on human mast cells

Author

DE PAULIS, AMATO, ANNUNZIATO F., DI GIOIA L., ROMAGNANI S., CARFORA M., BELTRAME C., ROMAGNANI P., MARONE, GIANNI, DE PAULIS, Amato, Annunziato, F., DI GIOIA, L., Romagnani, S., Carfora, M., Beltrame, C., Marone, Gianni, and Romagnani, P.

Published
2001

128. Studies of tau- -> eta.K-.nu and tau- -> eta.pi-.nu at BaBar and a search for a second-class current

Author

del Amo Sanchez, P., P. Lees, J., Poireau, V., Prencipe, E., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tanabe, T., M. Hawkes, C., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyako, S., I. Skovpen, Yu., P. Solodo, E., Yu. Todyshe, K., N. Yushko, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., West, C., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard, D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettonia, D., Bozzia, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontesea, L., Baldini-Ferroli, R., Calcaterra, A., de Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi, I., Piccolo, M., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggioa, S., Patrignani, C., Robuttia, E., Tosi, S., Bhuyan, B., Prasad, V., L. Lee, C., Morii, M., Adametz, A., Marks, J., Uwer, U., U. Bernlochner, F., Ebert, M., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., Sciolla, G., Zhao, M., Lindemann, D., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardoa, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., R. Kroeger, §, Sonnek, P., J. Summers, D., Nguyen, X., Simard, M., Taras, P., de Nardo, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morina, M., Posoccoa, M., Rotondoa, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Calderini, G., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Rossi, A., Angelini, C., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Cervelli, A., Forti, F., A. Giorgi, M., Lusiani, A., Neri, N., Paoloni, E., Rizzo, G., Walsha, J.J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telno, A., Anullia, F., Baracchini, E., Cavotoa, G., Faccini, R., Ferrarottoa, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzonia, M., Pireddaa, G., Rengaab, F., Hartmann, T., Leddig, T., Schr¨oder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel de Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., Pulliam, T., N. Ratcliff, B., Roodman, A., A. Salnikov, A., Santoro, V., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Sun, S., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Rul, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Lancer, L., Vitale, L., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., E. Latham, T., M. T. Puccio, E., R. Band, H., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
High Energy Physics::Phenomenology, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, 11.30.Ly, 13.35.Dx, 14.60.Fg, Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report on analyses of tau lepton decays $\tau^- \to \eta K^- \nu_{\tau}$ and $\tau^- \to \eta \pi^- \nu_{\tau}$, with $\eta \to \pi^+ \pi^- \pi^0$, using 470 fb$^{-1}$ of data from the Babar experiment at PEP-II, collected at center-of-mass energies at and near the $\Upsilon(4S)$ resonance. We measure the branching fraction for the $\tau^- \to \eta K^- \nu_{\tau}$ decay mode, $\Br(\tau^- \to \eta K^- \nu_{\tau}) = (1.42\pm0.11\text{(stat)}\pm0.07\text{(syst)})\times10^{-4}$, and report a 95% confidence level upper limit for the second-class current process $\tau^- \to \eta \pi^- \nu_{\tau}$, $\Br(\tau^- \to \eta \pi^- \nu_{\tau}) < 9.9\times10^{-5}$., Comment: 11 pages, 4 figures

Published
2011
Full Text
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130. A betaPP peptide carboxyl-terminal to Abeta is neurotoxic

Author

MARCON, Gabriella, GIACCONE G, CANCIANI B, CAJOLA L, ROSSI G, DE GIOIA L, SALMONA M, BUGIANI O, TAGLIAVINI F., Marcon, Gabriella, Giaccone, G, Canciani, B, Cajola, L, Rossi, G, DE GIOIA, L, Salmona, M, Bugiani, O, and Tagliavini, F.

Published
1999

131. Dalitz-plot Analysis of B0 --> D0bar pi+ pi

Author

Del Amo Sanchez, P., Lees, J.P., Poireau, V., Prencip, E., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tane, T., M. Hawkes, C., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., N. Yushkov, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., W. H. Toki,, M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard , D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettonic. Bozzi, D., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontesea, L., Baldini-Ferroli, R., Calcaterra, A., De Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi M. Piccolo, I., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggio, S., Patrignani, C., Robutti, E., Bhuyan, B., Prasad, V., L. Lee, C., Morii, M., Adametz, A., Marks, J., Uwer, U., U. Bernlochner, F., Ebert, M., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino Da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., J. West, T., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., Sciolla, G., Zhao, M., Lindemann, D., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardoa, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., Kroeger, R., Sonnek, P., J. Summers, D., Nguyen, X., Simard, M., Taras, P., De Nardo, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morandina, M., Posoccoa, M., Rotondoa, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Calderini, G., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Rossi, A., Angelini, C., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Cervelli, A., Forti, F., A. Giorgi, M., Lusianiac, A., Neri, N., Paoloni, E., Rizzo, G., Walsha, J.J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anullia, F., Baracchini, E., Cavotoa, G., Faccini, R., Ferrarottoa, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzonia, M., Pireddaa, G., Renga, F., Hartmann, T., Leddig, T., Schröder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel De Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., Pulliam, T., N. Ratcliff, B., Roodman, A., A. Salnikov, A., Santoro, V., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Sun, S., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., J. Sekula, S., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Lanceri, L., Vitale, L., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., E. Latham, T., M. T. Puccio, E., R. Band, H., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., Tisserand, V., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, and BABAR

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics - Experiment
Abstract

We report preliminary results from a study of the decay B0 --> D0bar pi+ pi- using a data sample of 470.9 +/- 2.8 million BBbar events collected with the BaBar detector at the Y(4S) resonance. Using the Dalitz-plot analysis technique, we find contributions from the intermediate resonances D*_2(2460)-, D*_0(2400)-, rho(770)0 and f_2(1270) as well as a pi+ pi- S-wave term, a D0bar pi- nonresonant S-wave term and a virtual D*(2010)- amplitude. We measure the branching fractions of the contributing decays., Comment: 15 pages, 6 figures, 6 tables, presented at ICHEP 2010

Published
2010

132. Measurement of |V_cb| and the Form-Factor Slope in Bbar -> D l- nubar Decays in Events Tagged by a Fully Reconstructed B Meson

Author

Aubert, B., Karyotakis, Y., Lees, J.P., Poireau, V., Prencipe, E., Prudent, X., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tackmann, K., Tanabe, T., M. Hawkes, C., Soni, N., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., G. Fulsom, B., Hearty, C., S. Mattison, T., A. Mckenna, J., Barrett, M., Khan, A., Randle-Conde, A., E. Blinov, V., D. Bukin, A., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., Bondioli, M., Curry, S., Eschrich, I., Kirkby, D., J. Lankford, A., Lund, P., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Yasin, Z., Zhang, L., Sharma, V., Campagnari, C., M. Hong, T., Kovalskyi, D., A. Mazur, M., D. Richman, J., W. Beck, T., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., Wang, L., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., Fang, F., G. Hitlin, D., Narsky, I., Piatenko, T., C. Porter, F., Andreassen, R., Mancinelli, G., T. Meadows, B., Mishra, K., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., F. Hirschauer, J., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., J. Wilson, R., Feltresi, E., Hauke, A., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., Nogowski, R., R. Schubert, K., Schwierz, R., Volk, A., Bernard , D., Latour, E., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettoni, D., Bozzi, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontese, L., Santoro, V., Baldini-Ferroli, R., Calcaterra, A., De Sangro, R., Finocchiaro, G., Pacetti, S., Patteri, P., M. Peruzzi, I., Piccolo, M., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggio, S., Patrignani, C., Robutti, E., Tosi, S., S. Chaisanguanthum, K., Morii, M., Adametz, A., Marks, J., Schenk, S., Uwer, U., U. Bernlochner, F., Klose, V., M. Lacker, H., J. Bard, D., D. Dauncey, P., Tibbetts, M., K. Behera, P., J. Charles, M., Mallik, U., Cochran, J., B. Crawley, H., Dong, L., Eyges, V., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., Gao, Y.Y., V. Gritsan, A., J. Guo, Z., Arnaud, N., Béquilleux, J., D'Orazio, A., Davier, M., Derkach, D., Firmino Da Costa, J., Grosdidier, G., Le Diberder, F., Lepeltier, V., M. Lutz, A., Malaescu, B., Pruvot, S., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., P. Burke, J., Chavez, C.A., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., K. Clarke, C., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., J. West, T., I. Yi, J., Anderson, J., Chen, C., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Saremi, S., Cowan, R., Dujmic, D., H. Fisher, P., W. Henderson, S., Sciolla, G., Spitznagel, M., K. Yamamoto, R., Zhao, M., M. Patel, P., H. Robertson, S., Schram, M., Lazzaro, A., Lombardo, V., Palombo, F., Stracka, S., M. Bauer, J., Cremaldi, L., Godang, R., Kroeger, R., Sonnek, P., J. Summers, D., W. Zhao, H., Simard, M., Taras, P., Nicholson, H., De Nardo, G., Lista, L., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kagan, H., Kass, R., P. Morris, J., M. Rahimi, A., Regensburger, J.J., J. Sekula, S., K. Wong, Q., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Lu, M., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Gagliardi, N., Margoni, M., Morandin, M., Posocco, M., Rotondo, M., Simonetto, F., Stroili, R., Voci, C., Del Amo Sanchez, P., Ben-Haim, E., R. Bonneaud, G., Briand, H., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Perez, A., Prendki, J., Sitt, S., Gladney, L., Biasini, M., Manoni, E., Angelini, C., Batignani, G., Bettarini, S., Calderini, G., Carpinelli, M., Cervelli, A., Forti, F., A. Giorgi, M., Lusiani, A., Morganti, M., Neri, N., Paoloni, E., Rizzo, G., J. Walsh, J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anulli, F., Baracchini, E., Cavoto, G., Faccini, R., Ferrarotto, F., Ferroni, F., Gaspero, M., D. Jacksona, P., Li Gioia, L., A. Mazzoni, M., Morganti, S., Piredda, G., Renga, F., Voena, C., Ebert, M., Hartmann, T., Schröder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Esteve, L., Hamel De Monchenault, G., Kozanecki, W., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., Bartoldus, R., F. Benitez, J., Cenci, R., P. Coleman, J., R. Convery, M., C. Dingfelder, J., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., Kaminski, J., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., Messner, R., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., N. Ratcliff, B., Roodman, A., A. Salnikov, A., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Suzuki, K., K. Swain, S., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Liu, Hong, Park, W., V. Purohit, M., M. White, R., R. Wilson, J., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Soffer, A., M. Spanier, S., J. Wogsland, B., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., W. Drummond, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Bosisio, L., Cartaro, C., Della Ricca, G., Lanceri, L., Vitale, L., Azzolini, V., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., Bhuyan, B., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., Ilic, J., E. Latham, T., B. Mohanty, G., M. T. Puccio, E., R. Band, H., Chen, X., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics - Experiment
Abstract

We present a measurement of the Cabibbo-Kobayashi-Maskawa matrix element |V_cb| and the form-factor slope rho^2 in Bbar -> Dl- nubar decays based on 460 million BBar events recorded at the Upsilon(4S) resonance with the BaBar detector. BBar -> Dl- nubar decays are selected in events in which a hadronic decay of the second B meson is fully reconstructed. We measure the differential decay rate and determine G(1) |V_cb|= (43.0 \pm 1.9 \pm 1.4)\times 10^{-3} and rho^2 = 1.20 \pm 0.09 \pm 0.04, where G(1) is the the hadronic form factor at the point of zero recoil. We also determine the exclusive branching fractions and find BF(B^- -> D0l- nubar) = (2.31 \pm 0.08 \pm 0.09)% and BF (B0bar -> D+ l^- nubar)=(2.23 \pm 0.11 \pm 0.11)%., Comment: 8 pages, 2 postscript figures, submitted to Physical Review Letters

Published
2010
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133. Observation of the decay B0bar -> LambdaC antiproton pi0

Author

Aubert, B., Karyotakis, Y., Lees, J.P., Poireau, V., Prencipe, E., Prudent, X., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tackmann, K., Tanabe, T., M. Hawkes, C., Soni, N., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Barrett, M., Khan, A., Randle-Conde, A., E. Blinov, V., D. Bukin, A., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., Bondioli, M., Curry, S., Eschrich, I., Kirkby, D., J. Lankford, A., Lund, P., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Yasin, Z., Sharma, V., Campagnari, C., M. Hong, T., Kovalskyi, D., A. Mazur, M., D. Richman, J., W. Beck, T., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., Wang, L., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., Fang, F., G. Hitlin, D., Narsky, I., Ongmongkolkul, P., Piatenko, T., C. Porter, F., Andreassen, R., Mancinelli, G., T. Meadows, B., Mishra, K., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., F. Hirschauer, J., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., Feltresi, E., Hauke, A., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., Nogowski, R., R. Schubert, K., Schwierz, R., Bernard , D., Latour, E., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettonia, D., Bozzia, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontesea, L., Santoro, V., Baldini-Ferroli, R., Calcaterra, A., De Sangro, R., Finocchiaro, G., Pacetti, S., Patteri, P., M. Peruzzi, I., M. Piccolo, ‡, Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggioa, S., Patrignani, C., Robuttia, E., Tosi, S., Morii, M., Adametz, A., Marks, J., Schenk, S., Uwer, U., U. Bernlochner, F., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., J. Charles, M., Mallik, U., Cochran, J., B. Crawley, H., Dong, L., Eyges, V., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., Gao, Y.Y., V. Gritsan, A., J. Guo, Z., Arnaud, N., D'Orazio, A., Davier, M., Derkach, D., Firmino Da Costa, J., Grosdidier, G., Le Diberder, F., Lepeltier, V., M. Lutz, A., Malaescu, B., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., P. Burke, J., Chavez, C.A., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., K. Clarke, C., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., J. West, T., I. Yi, J., Anderson, J., Chen, C., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., H. Fisher, P., W. Henderson, S., Sciolla, G., Spitznagel, M., K. Yamamoto, R., Zhao, M., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardoa, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., Kroeger, R., Sonnek, P., J. Summers, D., W. Zhao, H., Nguyen, X., Simard, M., Taras, P., Nicholson, H., De Nardo, G., Listaa, L., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kagan, H., Kass, R., P. Morris, J., M. Rahimi, A., J. Sekula, S., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Lu, M., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Gagliardi, N., Margoni, M., Morandina, M., Posoccoa, M., Rotondoa, M., Simonetto, F., Stroili, R., Voci, C., Del Amo Sanchez, P., Ben-Haim, E., R. Bonneaud, G., Briand, H., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Perez, A., Prendki, J., Sitt, S., Gladney, L., Biasini, M., Manoni, E., Angelini, C., Batignani, G., Bettarini, S., Calderini, G., Carpinelli, M., Cervelli, A., Forti, F., A. Giorgi, M., Lusianiac, A., Morganti, M., Neri, N., Paoloni, E., Rizzo, G., Walsha, J.J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anullia, F., Baracchini, E., Cavotoa, G., Faccini, R., Ferrarottoa, F., Ferroni, F., Gaspero, M., D. Jacksona, P., Li Gioia, L., A. Mazzonia, M., Morgantia, S., Pireddaa, G., Renga, F., Voenaa, C., Ebert, M., Hartmann, T., Schr¨oder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Esteve, L., Hamel De Monchenault, G., Kozanecki, W., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cenci, R., P. Coleman, J., R. Convery, M., C. Dingfelder, J., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., Kaminski, J., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., Messner, R., D. R. Muller,, Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., N. Ratcliff, B., Roodman, A., A. Salnikov, A., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Suzuki, K., K. Swain, S., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Liu, Hong, Park, W., V. Purohit, M., M. White, R., R. Wilson, J., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Soffer, A., M. Spanier, S., J. Wogsland, B., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., W. Drummond, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Bosisio, L., Cartaro, C., Della Ricca, G., Lanceri, L., Vitale, L., Azzolini, V., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., Bhuyan, B., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., Ilic, J., E. Latham, T., B. Mohanty, G., M. T. Puccio, E., R. Band, H., Chen, X., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
13.25.Hw, 13.60.Rj, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics - Experiment
Abstract

In a sample of 467 million $B\overline B$ pairs collected with the BABAR detector at the PEP-II collider at SLAC we have observed the decay $\overline{B}^0\rightarrow\Lambda_c^+{\overline p} \pi^0$ and measured the branching fraction to be $(1.94\pm0.17 \pm 0.14 \pm 0.50)\times 10^{-4}$, where the uncertainties are statistical, systematic, and the uncertainty on the $\Lambda_c^+\rightarrow p {K^-} \pi^+$ branching fraction, respectively. We determine an upper limit of $1.5\times 10^{-6}$ at $90\%$ C.L. for the product branching fraction ${\cal B} (\overline{B}^0\rightarrow \Sigma_c^+(2455)\overline p)\times{\cal B} (\Lambda_c^+\rightarrow p K^- \pi^+)$. Furthermore, we observe an enhancement at the threshold of the invariant mass of the baryon-antibaryon pair., Comment: 7 pages, 5 postscript figures, submitted to PRD RC

Published
2010
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134. Exclusive Production of $D^+_sD^-_s$, $D^{*+}_sD^-_s$, and $D^{*+}_sD^{*-}_s$ via $e^+ e^-$ Annihilation with Initial-State-Radiation

Author

Del Amo Sanchez, P., Lees, J.P., Poireau, V., Prencipe, E., Tisserand, V., Garra Tico E. Grauges, J., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tanabe, T., M. Hawkes, C., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., N. Yushkov, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard , D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettonia, D., Bozzia, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontesea, L., Baldini-Ferroli, R., Calcaterra, A., De Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi, I., M. Piccolo, †, Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggioa, S., Patrignani, C., Robuttia, E., Tosi, S., Bhuyan, B., Prasad, V., L. Lee, C., Morii, M., Adametz, A., Marks, J., Uwer, U., U. Bernlochner, F., Ebert, M., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino Da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., J. West, T., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., Sciolla, G., Zhao, M., Lindemann, D., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardoa, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., R. Kroeger, §, Sonnek, P., J. Summers, D., Nguyen, X., Simard, M., Taras, P., De Nardo, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morina, M., Posoccoa, M., Rotondoa, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Calderini, G., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Rossi, A., Angelini, C., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Cervelli, A., Forti, F., A. Giorgi, M., Lusianiac, A., Neri, N., Paoloni, E., Rizzo, G., Walsha, J.J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anullia, F., Baracchini, E., Cavotoa, G., Faccini, R., Ferrarottoa, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzonia, M., Pireddaa, G., Renga, F., Hartmann, T., Leddig, T., Schr¨oder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel De Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., Pulliam, T., N. Ratcliff, B., Roodman, A., A. Salnikov, A., Santoro, V., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Sun, S., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., J. Sekula, S., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Lanceri, L., Vitale, L., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., E. Latham, T., M. T. Puccio, E., R. Band, H., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], FOS: Physical sciences, High Energy Physics - Experiment, 14.40.Pq, 13.66.Bc, 13.25.Gv
Abstract

We perform a study of exclusive production of$D^+_sD^-_s$, $D^{*+}_sD^-_s$, and $D^{*+}_sD^{*-}_s$ final states in initial-state-radiation events from $e^+ e^-$ annihilations at a center-of-mass energy near 10.58 GeV, to search for charmonium $1^{--}$ states. The data sample corresponds to an integrated luminosity of 525 $fb^{-1}$ and was recorded by the BaBar experiment at the PEP-II storage ring. The $D^+_sD^-_s$, $D^{*+}_sD^-_s$, and $D^{*+}_sD^{*-}_s$ mass spectra show evidence of the known $\psi$ resonances. Limits are extracted for the branching ratios of the decays $X(4260)\to D^{(*)+}_sD^{(*)-}_s$., Comment: 12 pages, 6 postscript figures, submitted to Phys. Rev. D

Published
2010
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135. Observation of new resonances decaying to $D\pi$ and $D^*\pi$ in inclusive $e^+e^-$ collisions near $\sqrt{s}=$10.58 GeV

Author

Amo Sanchez, P.Del, P. Lees, J., Poireau, V., Prencipe, E., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tanabe, T., M. Hawkes, C., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., N. Yushkov, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., West, C., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard , D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettoni, D., Bozzia, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontesea, L., Baldini-Ferroli, R., Calcaterra, A., De Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi, I., Piccolo, M., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggio, S., Patrignani, C., Robutti, E., Tosi, S., Bhuyan, B., Prasad, V., L. Lee, C., Morii, M., Adametz, A., Marks, J., Uwer, U., U. Bernlochner, F., Ebert, M., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino Da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., Sciolla, G., Zhao, M., Lindemann, D., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardoa, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., R. Kroeger, §, Sonnek, P., J. Summers, D., Nguyen, X., Simard, M., Taras, P., De Nardo, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morandina, M., Posoccoa, M., Rotondoa, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Calderini, G., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Rossi, A., Angelini, C., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Cervelli, A., Forti, F., A. Giorgi, M., Lusiani, A., Neri, N., Paoloni, E., Rizzo, G., Walsha, J.J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anullia, F., Baracchini, E., Cavotoa, G., Faccini, R., Ferrarottoa, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzonia, M., Pireddaa, G., Renga, F., Hartmann, T., Leddig, T., Schr¨oder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel De Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., Pulliam, T., N. Ratcliff, B., Roodman, A., A. Salnikov, A., Santoro, V., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Sun, S., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., J. Sekula, S., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Lanceri, L., Vitale, L., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., E. Latham, T., M. T. Puccio, E., R. Band, H., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
14.40.Lb, 13.25.Ft, 12.38.-t, High Energy Physics::Phenomenology, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, High Energy Physics - Experiment
Abstract

We present a study of the $D^+\pi^-$, $D^0\pi^+$, and $D^{*+}\pi^-$ systems in inclusive $e^+e^- \rightarrow c\bar{c}$ interactions in a search for new excited $D$ meson states. We use a dataset, consisting of $\sim$454 fb$^{-1}$, collected at center-of-mass energies near 10.58 GeV by the BABAR detector at the SLAC PEP-II asymmetric-energy collider. We observe, for the first time, candidates for the radial excitations of the $D^0$, $D^{*0}$, and $D^{*+}$, as well as the L=2 excited states of the $D^0$ and $D^+$, where $L$ is the orbital angular momentum of the quarks., Comment: 8 pages, 7 postscript figures, accepted by PRD-RC

Published
2010
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136. Astronomia a Roma. Percorsi

Author

Lanciano, Nicoletta, Berardo, M., De Sanctis, E., Gioia, L., Morellato, J., Scippo, Stefano, Tomassetti, T., and Tutino, M.

Subjects
osservatorio astronomico, roma, città come luoghi educativi, meridiane a tangente, visite didattiche
Published
2010

137. Search for the Rare Decay B->K nu nubar

Author

del Amo Sanchez, P., Lees, J.P., Poireau, V., Prencipe, E., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tanabe, T., M. Hawkes, C., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., N. Yushkov, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., W. H. Toki,, Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard, D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettonia, D., Bozzia, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontese, L., Baldini-Ferroli, R., Calcaterra, A., de Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi, I., Piccolo, M., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggio, S., Patrignani, C., Robutti, E., Tosi, S., Bhuyan, B., Prasad, V., L. Lee, C., Morii, M., Adametz, A., Marks, J., Uwer, U., U. Bernlochner, F., Ebert, M., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., Gao, Y.Y., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., J. West, T., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., H. Fisher, P., Sciolla, G., Zhao, M., Lindemann, D., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardo, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., R. Kroeger, §, Sonnek, P., J. Summers, D., Nguyen, X., Simard, M., Taras, P., De, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morandin, M., Posocco, M., Rotondo, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Calderini, G., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Rossi, A., Angelini, C., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Cervelli, A., Forti, F., A. Giorgi, M., Lusiani, A., Neri, N., Paoloni, E., Rizzo, G., J. Walsh, J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anullia, F., Baracchini, E., Cavoto, G., Faccini, R., Ferrarotto, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzoni, M., Piredda, G., Renga, F., Hartmann, T., Leddig, T., Schroder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel de Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., Pulliam, T., N. Ratcliff, B., Roodman, A., A. Salnikov, A., Santoro, V., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Sun, S., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., J. Sekula, S., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Lanceri, L., Vitale, L., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., E. Latham, T., M. T. Puccio, E., R. Band, H., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics - Experiment
Abstract

We present a search for the rare decays B+ -> K+ nu nubar and B0 -> K0 nu nubar using 459 million BBbar pairs collected with the BaBar detector at the SLAC National Accelerator Laboratory. Flavor-changing neutral-current decays such as these are forbidden at tree level but can occur through one-loop diagrams in the Standard Model (SM), with possible contributions from new physics at the same order. The presence of two neutrinos in the final state makes identification of signal events challenging, so reconstruction in the semileptonic decay channels B -> D(*) l nu of the B meson recoiling from the signal B is used to suppress backgrounds. We set an upper limit at the 90% confidence level of 1.3 x 10^{-5} on the total branching fraction for B+ -> K+ nu nubar, and 5.6 x 10^{-5} for B0 -> K0 nu nubar. We additionally report partial branching fractions in two ranges of di-neutrino mass squared for B+ -> K+ nu nubar., Comment: 10 pages, 6 postscript figures

Published
2010
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138. Observation of the Rare Decay B0 --> KsK+/-pi-/+

Author

del Amo Sanchez, P., P. Lees, J., Poireau, V., Prencipe, E., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tanabe, T., M. Hawkes, C., Soni, N., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., N. Yushkov, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Yasin, Z., Sharma, V., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., F. Hirschauer, J., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., Hauke, A., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard, D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettonia, D., Bozzia, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontese, L., Baldini-Ferroli, R., Calcaterra, A., de Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi, I., Piccolo, M., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggio, S., Patrignani, C., Robutti, E., Tosi, S., Bhuyan, B., Morii, M., Adametz, A., Marks, J., Schenk, S., Uwer, U., U. Bernlochner, F., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., Gao, Y.Y., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., P. Burke, J., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., J. West, T., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., H. Fisher, P., Sciolla, G., K. Yamamoto, R., Zhao, M., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardo, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., Kroeger, R., Sonnek, P., J. Summers, D., W. Zhao, H., Nguyen, X., Simard, M., Taras, P., de Nardo, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., M. Rahimi, A., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morandin, M., Posocco, M., Rotondo, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Angelini, C., Batignani, G., Bettarini, S., Calderini, G., Carpinelli, M., Cervelli, A., Forti, F., A. Giorgi, M., Lusiani, A., Neri, N., Paoloni, E., Rizzo, G., J. Walsh, J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anulli, F., Baracchini, E., Cavoto, G., Faccini, R., Ferrarotto, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzoni, M., Piredda, G., Renga, F., Ebert, M., Hartmann, T., Leddig, T., Schröder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel de Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., N. Ratcliff, B., Roodman, A., A. Salnikov, A., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., Santoro, V., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., J. Sekula, S., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Della Ricca, G., Lanceri, L., Vitale, L., Azzolini, V., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., Ilic, J., E. Latham, T., B. Mohanty, G., M. T. Puccio, E., R. Band, H., Chen, X., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
High Energy Physics - Phenomenology, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics - Experiment
Abstract

We report an analysis of charmless hadronic decays of neutral B mesons to the final state KsK+/-pi-/+, using a data sample of (465 +/- 5) x 10^6 BB-bar events collected with the BABAR detector at the Y(4S) resonance. We observe an excess of signal events with a significance of 5.2 standard deviations including systematic uncertainties and measure the branching fraction to be BF(B0 --> KsK+/-pi-/+) = (3.2 +/- 0.5 +/- 0.3) x 10^-6, where the uncertainties are statistical and systematic, respectively., Comment: 8 pages, 5 postscript figures, published in PRD(RC)

Published
2010
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139. Measurement of the Absolute Branching Fractions for $D^-_s\!\rightarrow\!\ell^-\bar{\nu}_{\ell}$ and Extraction of the Decay Constant $f_{D_s}$

Author

Del Amo Sanchez, P., Lees, J.P., Poireau, V., Prencipe, E., Tisserand, V., Garra Tico, J., Grauges, E., Martinelli, M., Palano, A., Pappagallo, M., Eigen, G., Stugu, B., Sun, Luyan, Battaglia, M., N. Brown, D., Hooberman, B., T. Kerth, L., G. Kolomensky, Yu., Lynch, G., L. Osipenkov, I., Tanabe, T., M. Hawkes, C., T. Watson, A., Koch, H., Schroeder, T., J. Asgeirsson, D., Hearty, C., S. Mattison, T., A. Mckenna, J., Khan, A., Randle-Conde, A., E. Blinov, V., R. Buzykaev, A., P. Druzhinin, V., B. Golubev, V., P. Onuchin, A., I. Serednyakov, S., I. Skovpen, Yu., P. Solodov, E., Yu. Todyshev, K., N. Yushkov, A., Bondioli, M., Curry, S., Kirkby, D., J. Lankford, A., Mandelkern, M., C. Martin, E., P. Stoker, D., Atmacan, H., W. Gary, J., Liu, Franklin, Long, O., M. Vitug, G., Campagnari, C., M. Hong, T., Kovalskyi, D., D. Richman, J., West, C., M. Eisner, A., Heusch, C.A., Kroseberg, J., S. Lockman, W., J. Martinez, A., Schalk, T., A. Schumm, B., Seiden, A., O. Winstrom, L., H. Cheng, C., Doll, D.A., Echenard, B., G. Hitlin, D., Ongmongkolkul, P., C. Porter, F., Y. Rakitin, A., Andreassen, R., S. Dubrovin, M., Mancinelli, G., T. Meadows, B., D. Sokoloff, M., C. Bloom, P., T. Ford, W., Gaz, A., Nagel, M., Nauenberg, U., G. Smith, J., R. Wagner, S., Ayad, R., H. Toki, W., Jasper, H., M. Karbach, T., Merkel, J., Petzold, A., Spaan, B., Wacker, K., J. Kobel, M., R. Schubert, K., Schwierz, R., Bernard , D., Verderi, M., J. Clark, P., Playfer, S., E. Watson, J., Andreotti, M., Bettoni, D., Bozzi, C., Calabrese, R., Cecchi, A., Cibinetto, G., Fioravanti, E., Franchini, P., Luppi, E., Munerato, M., Negrini, M., Petrella, A., Piemontese, L., Baldini-Ferroli, R., Calcaterra, A., De Sangro, R., Finocchiaro, G., Nicolaci, M., Pacetti, S., Patteri, P., M. Peruzzi, I., Piccolo, M., Rama, M., Zallo, A., Contri, R., Guido, E., Lo Vetere, M., R. Monge, M., Passaggio, S., Patrignani, C., Robutti, E., Tosi, S., Bhuyan, B., Prasad, V., L. Lee, C., Morii, M., Adametz, A., Marks, J., Uwer, U., U. Bernlochner, F., Ebert, M., M. Lacker, H., Lueck, T., Volk, A., D. Dauncey, P., Tibbetts, M., K. Behera, P., Mallik, U., Chen, C., Cochran, J., B. Crawley, H., Dong, L., T. Meyer, W., Prell, S., I. Rosenberg, E., E. Rubin, A., V. Gritsan, A., J. Guo, Z., Arnaud, N., Davier, M., Derkach, D., Firmino Da Costa, J., Grosdidier, G., Le Diberder, F., M. Lutz, A., Malaescu, B., Perez, A., Roudeau, P., H. Schune, M., Serrano, J., Sordini, V., Stocchi, A., Wang, L., Wormser, G., J. Lange, D., M. Wright, D., Bingham, I., Chavez, C.A., P. Coleman, J., R. Fry, J., Gabathuler, E., Gamet, R., E. Hutchcroft, D., J. Payne, D., Touramanis, C., J. Bevan, A., Di Lodovico, F., Sacco, R., Sigamani, M., Cowan, G., Paramesvaran, S., C. Wren, A., L. Davis, C., G. Denig, A., Fritsch, M., Gradl, W., Hafner, A., E. Alwyn, K., Bailey, D., J. Barlow, R., Jackson, G., D. Lafferty, G., Anderson, J., Cenci, R., Jawahery, A., Roberts, D.A., Simi, G., M. Tuggle, J., Dallapiccola, C., Salvati, E., Cowan, R., Dujmic, D., Sciolla, G., Zhao, M., Lindemann, D., M. Patel, P., H. Robertson, S., Schram, M., Biassoni, P., Lazzaro, A., Lombardo, V., Palombo, F., Stracka, S., Cremaldi, L., Godang, R., Kroeger, R., Sonnek, P., J. Summers, D., Nguyen, X., Simard, M., Taras, P., De, G., Monorchio, D., Onorato, G., Sciacca, C., Raven, G., L. Snoek, H., P. Jessop, C., J. Knoepfel, K., M. Losecco, J., F. Wang, W., Corwin, L.A., Honscheid, K., Kass, R., P. Morris, J., L. Blount, N., Brau, J., Frey, R., Igonkina, O., A. Kolb, J., Rahmat, R., B. Sinev, N., Strom, D., Strube, J., Torrence, E., Castelli, G., Feltresi, E., Gagliardi, N., Margoni, M., Morandin, M., Posocco, M., Rotondo, M., Simonetto, F., Stroili, R., Ben-Haim, E., R. Bonneaud, G., Briand, H., Calderini, G., Chauveau, J., Hamon, O., Leruste, Ph., Marchiori, G., Ocariz, J., Prendki, J., Sitt, S., Biasini, M., Manoni, E., Rossi, A., Angelini, C., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Cervelli, A., Forti, F., A. Giorgi, M., Lusiani, A., Neri, N., Paoloni, E., Rizzo, G., J. Walsh, J., Lopes Pegna, D., Lu, C., Olsen, J., J. S. Smith, A., V. Telnov, A., Anulli, F., Baracchini, E., Cavoto, G., Faccini, R., Ferrarotto, F., Ferroni, F., Gaspero, M., Li Gioia, L., A. Mazzoni, M., Piredda, G., Renga, F., Hartmann, T., Leddig, T., Schroder, H., Waldi, R., Adye, T., Franek, B., O. Olaiya, E., F. Wilson, F., Emery, S., Hamel De Monchenault, G., Vasseur, G., Yèche, Ch., Zito, M., T. Allen, M., Aston, D., J. Bard, D., Bartoldus, R., F. Benitez, J., Cartaro, C., R. Convery, M., Dorfan, J., P. Dubois-Felsmann, G., Dunwoodie, W., C. Field, R., Franco Sevilla, M., G. Fulsom, B., M. Gabareen, A., T. Graham, M., Grenier, P., Hast, C., R. Innes, W., H. Kelsey, M., Kim, H., Kim, P., L. Kocian, M., W. G. S. Leith, D., Li, S., Lindquist, B., Luitz, S., Luth, V., L. Lynch, H., B. Macfarlane, D., Marsiske, H., R. Muller, D., Neal, H., Nelson, S., P. O'Grady, C., Ofte, I., Perl, M., Pulliam, T., N. Ratcliff, B., Roodman, A., A. Salnikov, A., Santoro, V., H. Schindler, R., Schwiening, J., Snyder, A., Su, D., K. Sullivan, M., Sun, S., Suzuki, K., M. Thompson, J., Va'Vra, J., P. Wagner, A., Weaver, M., West, C.A., J. Wisniewski, W., Wittgen, M., H. Wright, D., W. Wulsin, H., K. Yarritu, A., C. Young, C., Ziegler, V., R. Chen, X., Park, W., V. Purohit, M., M. White, R., R. Wilson, J., J. Sekula, S., Bellis, M., R. Burchat, P., J. Edwards, A., S. Miyashita, T., Ahmed, Mohamed-Salem, S. Alam, M., A. Ernst, J., Pan, B., A. Saeed, M., B. Zain, S., Guttman, N., Soffer, A., Lund, P., M. Spanier, S., Eckmann, R., L. Ritchie, J., M. Ruland, A., J. Schilling, C., F. Schwitters, R., C. Wray, B., M. Izen, J., C. Lou, X., Bianchi, F., Gamba, D., Pelliccioni, M., Bomben, M., Lanceri, L., Vitale, L., Lopez-March, N., Martinez-Vidal, F., Milanes, D.A., Oyanguren, A., Albert, J., Banerjee, Sw., H. F. Choi, H., Hamano, K., J. King, G., Kowalewski, R., J. Lewczuk, M., M. Nugent, I., M. Roney, J., J. Sobie, R., J. Gershon, T., F. Harrison, P., E. Latham, T., M. T. Puccio, E., R. Band, H., Dasu, S., T. Flood, K., Pan, Y., Prepost, R., O. Vuosalo, C., L. Wu, S., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BABAR, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
High Energy Physics::Phenomenology, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, High Energy Physics - Experiment
Abstract

The absolute branching fractions for the decays $D^-_s\!\rightarrow\!\ell^-\bar{\nu}_{\ell}$ ($\ell=e$, $\mu$, or $\tau$) are measured using a data sample corresponding to an integrated luminosity of 521 fb$^{-1}$ collected at center of mass energies near 10.58 GeV with the \mbox{\slshape B\kern-0.1em{\smaller A}\kern-0.1em B\kern-0.1em{\smaller A\kern-0.2em R}} detector at the PEP-II $e^+e^-$ collider at SLAC. The number of $D^-_s$ mesons is determined by reconstructing the recoiling system $DKX\gamma$ in events of the type $e^+e^-{\rightarrow}DKXD^{*-}_s$, where $D^{*-}_s\rightarrow D^-_s\gamma$ and $X$ represents additional pions from fragmentation. The $D^-_s\!\rightarrow\!\ell^-\bar{\nu}_{\ell}$ events are detected by full or partial reconstruction of the recoiling system $DKX\gamma\ell$. The branching fraction measurements are combined to determine the $D^-_s$ decay constant $f_{D_s} = (258.6 \pm 6.4 \pm 7.5)$ MeV, where the first uncertainty is statistical and the second is systematic., Comment: 8 pages, 3 postscript figures

Published
2010
Full Text
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141. The oxidative inactivation of FeFe hydrogenase reveals the plasticity of the H-cluster

Author

Fourmond, V, Baffert, C, Ezanno, P, Leger, C, Greco, C, Bruschi, M, DE GIOIA, L, Sybirna, K, Bottin, H, Meynial Salles, I, Soucaille, P, Wang, P, Montefiori, M, Blumberger, J, Blumberger, J., GRECO, CLAUDIO, DE GIOIA, LUCA, Fourmond, V, Baffert, C, Ezanno, P, Leger, C, Greco, C, Bruschi, M, DE GIOIA, L, Sybirna, K, Bottin, H, Meynial Salles, I, Soucaille, P, Wang, P, Montefiori, M, Blumberger, J, Blumberger, J., GRECO, CLAUDIO, and DE GIOIA, LUCA

Published
2014

144. Il Piano Lauree Scientifiche – Area Chimica all’Università di Milano-Bicocca

Author

Anzellotti, G, Catena, LM, Catti, M, Cosentino, U, Immè, J, Vittorio, N, Bruschi, M, Greco, C, Zoia, L, DE GIOIA, L, Moro, G, La Grasta, C, Frasconà, C, COSENTINO, UGO RENATO, BRUSCHI, MAURIZIO, GRECO, CLAUDIO, ZOIA, LUCA, DE GIOIA, LUCA, MORO, GIORGIO, Frasconà, C., Anzellotti, G, Catena, LM, Catti, M, Cosentino, U, Immè, J, Vittorio, N, Bruschi, M, Greco, C, Zoia, L, DE GIOIA, L, Moro, G, La Grasta, C, Frasconà, C, COSENTINO, UGO RENATO, BRUSCHI, MAURIZIO, GRECO, CLAUDIO, ZOIA, LUCA, DE GIOIA, LUCA, MORO, GIORGIO, and Frasconà, C.

Published
2014

145. DFT Investigation of Models Related to the Active Siteof Hydrogenases

Author

Greco, C, DE GIOIA, L, GRECO, CLAUDIO, DE GIOIA, LUCA, Greco, C, DE GIOIA, L, GRECO, CLAUDIO, and DE GIOIA, LUCA

Abstract

From a methodological perspective, most quantum-chemical studies of hydrogenases and related models have been carried out within the theoretical framework of the density functional theory (DFT), a choice that stems principally from the very good trade-off between the accuracy of DFT and its relatively low computational cost. This chapter presents a non comprehensive overview of quantum mechanics (QM) studies of molecular models related to the active site of hydrogenases and aims to show how computational studies have contributed to the elucidation of key properties of hydrogenases, as well as of related synthetic compounds. When considering biomimetic models, recent results have highlighted the importance of coupled proton-electron transfer for efficient H2 formation or oxidation, and computational studies are expected to play an important role in the design of novel and more efficient synthetic catalysts.

Published
2014

146. Quantum mechanical methods for the investigation of metalloproteins and related bioinorganic compounds

Author

Fontecilla-Camps, JC, Nicolet, Y, Bertini, L, Bruschi, M, Cosentino, U, Greco, C, Moro, G, Zampella, G, DE GIOIA, L, BERTINI, LUCA, BRUSCHI, MAURIZIO, GRECO, CLAUDIO, MORO, GIORGIO, ZAMPELLA, GIUSEPPE, DE GIOIA, LUCA, Fontecilla-Camps, JC, Nicolet, Y, Bertini, L, Bruschi, M, Cosentino, U, Greco, C, Moro, G, Zampella, G, DE GIOIA, L, BERTINI, LUCA, BRUSCHI, MAURIZIO, GRECO, CLAUDIO, MORO, GIORGIO, ZAMPELLA, GIUSEPPE, and DE GIOIA, LUCA

Abstract

It is well known that transition metal ions are often bound to proteins, conveying very specific functional properties. In fact, metalloproteins play crucial biological roles in the transport and activation of small molecules such as H-2, O-2, and N-2, as well as in several other biochemical processes. However, even if the presence of transition metals in the active site of proteins allows a very rich biochemistry, the experimental disclosure of structure-activity relationships in metalloproteins is generally difficult exactly because of the presence of transition metals, which are intrinsically characterized by a very versatile and often elusive chemistry. For this reason, computational methods are becoming very popular tools in the characterization of metalloproteins. In particular, since computing power is becoming less and less expensive, due to the continuous technological development of CPUs, the computational tools suited to investigate metalloproteins are becoming more accessible and therefore more commonly used also in molecular biology and biochemistry laboratories. Here, we present the main procedures and computational methods based on quantum mechanics, which are commonly used to study the structural, electronic, and reactivity properties of metalloproteins and related bioinspired compounds, with a specific focus on the practical and technical aspects that must be generally tackled to properly study such biomolecular systems.

Published
2014

147. Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches

Author

Arrigoni, A, Bertini, L, De Gioia, L, Papaleo, E, Papaleo, E., Arrigoni, A, Bertini, L, De Gioia, L, Papaleo, E, and Papaleo, E.

Abstract

Among the different classes of enzymes involved in the ubiquitin pathway, E2 ubiquitin-conjugating enzymes occupy a central role in the ubiquitination cascade. Cdc34-like E2 enzymes are characterized by a 12-14 residue insertion in the proximity of the catalytic site, known as the acidic loop. Cdc34 ubiquitin-charging activity is regulated by CK2-dependent phosphorylation and the regulatory mechanism involves the acidic loop. Indeed, the phosphorylation stabilizes the loop in an open conformation that is competent for ubiquitin charging.Cdc34 is associated with a variety of diseases, such as hepatocellular carcinomas and prostatic adenocarcinomas. In light of its role, the discovery of potential inhibitory compounds would provide the mean to effectively modulate its activity.Here, we carried out a computational study based on molecular dynamics, virtual screening and docking to identify potential inhibitory compounds of Cdc34, modulating the acidic loop conformation. The molecules identified in this study have been designed to act as molecular hinges that can bind the acidic loop in its closed conformation, thus inhibiting the Cdc34-mediated ubiquitination cascade at the ubiquitin-charging step. In particular, we proposed a pharmacophore model featuring two amino groups in the central part of the model and two lateral aromatic chains, which respectively establish electrostatic interactions with the acidic loop (Asp 108 and Glu 109) and a hydrogen bond with Ser 139, which is one of the key residues for Cdc34 activity. © 2014 The Authors.

Published
2014

148. An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection

Author

Forni, D, Cagliani, R, Tresoldi, C, Pozzoli, U, DE GIOIA, L, Filippi, G, Riva, S, Menozzi, G, Colleoni, M, Biasin, M, Lo Caputo, S, Mazzotta, F, Comi, G, Bresolin, N, Clerici, M, Sironi, M, Sironi, M., DE GIOIA, LUCA, FILIPPI, GIULIA, Forni, D, Cagliani, R, Tresoldi, C, Pozzoli, U, DE GIOIA, L, Filippi, G, Riva, S, Menozzi, G, Colleoni, M, Biasin, M, Lo Caputo, S, Mazzotta, F, Comi, G, Bresolin, N, Clerici, M, Sironi, M, Sironi, M., DE GIOIA, LUCA, and FILIPPI, GIULIA

Abstract

The antigenic repertoire presented by MHC molecules is generated by the antigen processing and presentation (APP) pathway. We analyzed the evolutionary history of 45 genes involved in APP at the inter- and intra-species level. Results showed that 11 genes evolved adaptively in mammals. Several positively selected sites involve positions of fundamental importance to the protein function (e.g. the TAP1 peptide-binding domains, the sugar binding interface of langerin, and the CD1D trafficking signal region). In CYBB, all selected sites cluster in two loops protruding into the endosomal lumen; analysis of missense mutations responsible for chronic granulomatous disease (CGD) showed the action of different selective forces on the very same gene region, as most CGD substitutions involve aminoacid positions that are conserved in all mammals. As for ERAP2, different computational methods indicated that positive selection has driven the recurrent appearance of protein-destabilizing variants during mammalian evolution. Application of a population-genetics phylogenetics approach showed that purifying selection represented a major force acting on some APP components (e.g. immunoproteasome subunits and chaperones) and allowed identification of positive selection events in the human lineage.We also investigated the evolutionary history of APP genes in human populations by developing a new approach that uses several different tests to identify the selection target, and that integrates low-coverage whole-genome sequencing data with Sanger sequencing. This analysis revealed that 9 APP genes underwent local adaptation in human populations. Most positive selection targets are located within noncoding regions with regulatory function in myeloid cells or act as expression quantitative trait loci. Conversely, balancing selection targeted nonsynonymous variants in TAP1 and CD207 (langerin). Finally, we suggest that selected variants in PSMB10 and CD207 contribute to human phenotypes. Thus

Published
2014

149. Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes

Author

Greco, C, Fourmond, V, Baffert, C, Wang, P, Dementin, S, Bertrand, P, Bruschi, M, Blumberger, J, DE GIOIA, L, Léger, C, GRECO, CLAUDIO, BRUSCHI, MAURIZIO, DE GIOIA, LUCA, Léger, C., Greco, C, Fourmond, V, Baffert, C, Wang, P, Dementin, S, Bertrand, P, Bruschi, M, Blumberger, J, DE GIOIA, L, Léger, C, GRECO, CLAUDIO, BRUSCHI, MAURIZIO, DE GIOIA, LUCA, and Léger, C.

Abstract

After enzymes were first discovered in the late XIX century, and for the first seventy years of enzymology, kinetic experiments were the only source of information about enzyme mechanisms. Over the following fifty years, these studies were taken over by approaches that give information at the molecular level, such as crystallography, spectroscopy and theoretical chemistry (as emphasized by the Nobel Prize in Chemistry awarded last year to M. Karplus, M. Levitt and A. Warshel). In this review, we thoroughly discuss the interplay between the information obtained from theoretical and experimental methods, by focussing on enzymes that process small molecules such as H2 or CO2 (hydrogenases, CO-dehydrogenase and carbonic anhydrase), and that are therefore relevant in the context of energy and environment. We argue that combining theoretical chemistry (DFT, MD, QM/MM) and detailed investigations that make use of modern kinetic methods, such as protein film voltammetry, is an innovative way of learning about individual steps and/or complex reactions that are part of the catalytic cycles. We illustrate this with recent results from our labs and others, including studies of gas transport along substrate channels, long range proton transfer, and mechanisms of catalysis, inhibition or inactivation

Published
2014

150. Structural investigation of the cold-adapted acylaminoacyl peptidase from Sporosarcina psychrophila by atomistic simulations and biophysical methods

Author

Papaleo, E, Parravicini, F, Grandori, R, DE GIOIA, L, Brocca, S, PAPALEO, ELENA, PARRAVICINI, FEDERICA, GRANDORI, RITA, DE GIOIA, LUCA, BROCCA, STEFANIA, Papaleo, E, Parravicini, F, Grandori, R, DE GIOIA, L, Brocca, S, PAPALEO, ELENA, PARRAVICINI, FEDERICA, GRANDORI, RITA, DE GIOIA, LUCA, and BROCCA, STEFANIA

Abstract

Protein structure and dynamics are crucial for protein function. Thus, the study of conformational properties can be very informative for characterizing new proteins and to rationalize how residue substitutions at specific protein sites affect its dynamics, activity and thermal stability. Here, we investigate the structure and dynamics of the recently isolated cold-adapted acylaminoacyl peptidase from Sporosarcina psychrophila (SpAAP) by the integration of simulations, circular dichroism, mass spectrometry and other experimental data. Our study notes traits of cold-adaptation, such as lysine-to-arginine substitutions and a lack of disulphide bridges. Cold-adapted enzymes are generally characterized by a higher number of glycine residues with respect to their warm-adapted counterparts. Conversely, the SpAAP glycine content is lower than that in the warm-adapted variants. Nevertheless, glycine residues are strategically located in proximity to the functional sites in SpAAP, such as the active site and the linker between the two domains. In particular, G457 reduces the steric hindrance around the nucleophile elbow. Our results suggest a local weakening of the intramolecular interactions in the cold-adapted enzyme. This study offers a basis for the experimental mutagenesis of SpAAP and related enzymes. The approaches employed in this study may also provide a more general framework to characterize new protein structures in the absence of X-ray or NMR data.

Published
2014

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