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1,315 results on '"Gerszten, Robert E."'

101. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Author

Tynkkynen, Juho, Chouraki, Vincent, van der Lee, Sven J., Hernesniemi, Jussi, Yang, Qiong, Li, Shuo, Beiser, Alexa, Larson, Martin G., Sääksjärvi, Katri, Shipley, Martin J., Singh-Manoux, Archana, Gerszten, Robert E., Wang, Thomas J., Havulinna, Aki S., Würtz, Peter, Fischer, Krista, Demirkan, Ayse, Ikram, M. Arfan, Amin, Najaf, Lehtimäki, Terho, Kähönen, Mika, Perola, Markus, Metspalu, Andres, Kangas, Antti J., Soininen, Pasi, Ala-Korpela, Mika, Vasan, Ramachandran S., Kivimäki, Mika, van Duijn, Cornelia M., Seshadri, Sudha, and Salomaa, Veikko

Published
2018
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102. Increases in Myocardial Workload Induced by Rapid Atrial Pacing Trigger Alterations in Global Metabolism

Author

Turer, Aslan T, Lewis, Gregory D, O'Sullivan, John F, Elmariah, Sammy, Mega, Jessica L, Addo, Tayo A, Sabatine, Marc S, de Lemos, James A, and Gerszten, Robert E

Subjects
Medical Biochemistry and Metabolomics, Analytical Chemistry, Biomedical and Clinical Sciences, Chemical Sciences, Cardiovascular, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Amino Acids, Angina Pectoris, Bile Acids and Salts, Carbohydrates, Cardiac Catheterization, Cardiac Pacing, Artificial, Comorbidity, Coronary Sinus, Female, Heart, Heterocyclic Compounds, Humans, Lipolysis, Male, Mass Spectrometry, Metabolic Syndrome, Metabolome, Middle Aged, Myocardial Contraction, Myocardial Ischemia, Smoking, Thyroid Hormones, Tryptophan Hydroxylase, General Science & Technology
Abstract

ObjectiveTo determine whether increases in cardiac work lead to alterations in the plasma metabolome and whether such changes arise from the heart or peripheral organs.BackgroundThere is growing evidence that the heart influences systemic metabolism through endocrine effects and affecting pathways involved in energy homeostasis.MethodsNineteen patients referred for cardiac catheterization were enrolled. Peripheral and selective coronary sinus (CS) blood sampling was performed at serial timepoints following the initiation of pacing, and metabolite profiling was performed by liquid chromatography-mass spectrometry (LC-MS).ResultsPacing-stress resulted in a 225% increase in the median rate·pressure product from baseline. Increased myocardial work induced significant changes in the peripheral concentration of 43 of 125 metabolites assayed, including large changes in purine [adenosine (+99%, p = 0.006), ADP (+42%, p = 0.01), AMP (+79%, p = 0.004), GDP (+69%, p = 0.003), GMP (+58%, p = 0.01), IMP (+50%, p = 0.03), xanthine (+61%, p = 0.0006)], and several bile acid metabolites. The CS changes in metabolites qualitatively mirrored those in the peripheral blood in both timing and magnitude, suggesting the heart was not the major source of the metabolite release.ConclusionsIsolated increases in myocardial work can induce changes in the plasma metabolome, but these changes do not appear to be directly cardiac in origin. A number of these dynamic metabolites have known signaling functions. Our study provides additional evidence to a growing body of literature on metabolic 'cross-talk' between the heart and other organs.

Published
2014

103. A Plasma Long‐Chain Acylcarnitine Predicts Cardiovascular Mortality in Incident Dialysis Patients

Author

Kalim, Sahir, Clish, Clary B, Wenger, Julia, Elmariah, Sammy, Yeh, Robert W, Deferio, Joseph J, Pierce, Kerry, Deik, Amy, Gerszten, Robert E, Thadhani, Ravi, and Rhee, Eugene P

Subjects
Cardiovascular, Clinical Research, Kidney Disease, Good Health and Well Being, Aged, Aged, 80 and over, Biomarkers, Cardiovascular Diseases, Carnitine, Case-Control Studies, Chi-Square Distribution, Chromatography, Liquid, Female, Humans, Kidney Failure, Chronic, Logistic Models, Male, Mass Spectrometry, Metabolomics, Middle Aged, Multivariate Analysis, Odds Ratio, Prospective Studies, Renal Dialysis, Risk Factors, Time Factors, Treatment Outcome, Uremia, cardiovascular disease, dialysis, metabolism, mortality, risk factors, Cardiorespiratory Medicine and Haematology
Abstract

BackgroundThe marked excess in cardiovascular mortality that results from uremia remains poorly understood.Methods and resultsIn 2 independent, nested case-control studies, we applied liquid chromatography-mass spectrometry-based metabolite profiling to plasma obtained from participants of a large cohort of incident hemodialysis patients. First, 100 individuals who died of a cardiovascular cause within 1 year of initiating hemodialysis (cases) were randomly selected along with 100 individuals who survived for at least 1 year (controls), matched for age, sex, and race. Four highly intercorrelated long-chain acylcarnitines achieved the significance threshold adjusted for multiple testing (P

Published
2013

105. Lac-Phe mediates the anti-obesity effect of metformin

Author

Xiao, Shuke, primary, Li, Veronica L., additional, Lyu, Xuchao, additional, Chen, Xudong, additional, Wei, Wei, additional, Abbasi, Fahim, additional, Knowles, Joshua W., additional, Deng, Shuliang, additional, Tiwari, Gaurav, additional, Shi, Xu, additional, Zheng, Shuning, additional, Farrell, Laurie, additional, Chen, Zsu-Zsu, additional, Taylor, Kent D., additional, Guo, Xiuqing, additional, Goodarzi, Mark O., additional, Wood, Alexis C., additional, Chen, Yii-Der Ida, additional, Lange, Leslie A., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Clish, Clary B., additional, Tahir, Usman A., additional, Gerszten, Robert E., additional, Benson, Mark D., additional, and Long, Jonathan Z., additional

Published
2023
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106. Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability

Author

Hota, Monalisa, primary, Barber, Jacob L, additional, Ruiz-Ramie, Jonathan J., additional, Schwartz, Charles S., additional, Lam, Do Thuy Uyen Ha, additional, Rao, Prashant, additional, Mi, Michael Y., additional, Katz, Daniel H., additional, Robbins, Jeremy, additional, Clish, Clary B., additional, Gerszten, Robert E, additional, Sarzynski, Mark A., additional, Ghosh, Sujoy, additional, and Bouchard, Claude, additional

Published
2023
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107. Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension

Author

Rao, Prashant, Keyes, Michelle. J., Mi, Michael Y., Barber, Jacob L., Tahir, Usman A., Deng, Shuliang, Clish, Clary B., Shen, Dongxiao, Farrell, Laurie. A., Wilson, James G., Gao, Yan, Yimer, Wondwosen K., Ekunwe, Lynette, Hall, Michael E., Muntner, Paul M., Guo, Xiuqing, Taylor, Kent D., Tracy, Russell P., Rich, Stephen S., Rotter, Jerome I., Xanthakis, Vanessa, Vasan, Ramachandran S., Bouchard, Claude, Sarzynski, Mark A., Gerszten, Robert E., and Robbins, Jeremy M.

Abstract

IMPORTANCE: Blood pressure response during acute exercise (exercise blood pressure [EBP]) is associated with the future risk of hypertension and cardiovascular disease (CVD). Biochemical characterization of EBP could inform disease biology and identify novel biomarkers of future hypertension. OBJECTIVE: To identify protein markers associated with EBP and test their association with incident hypertension. DESIGN, SETTING, AND PARTICIPANTS: This study assayed 4977 plasma proteins in 681 healthy participants (from 763 assessed) of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE; data collection from January 1993 to December 1997 and plasma proteomics from January 2019 to January 2020) Family Study at rest who underwent 2 cardiopulmonary exercise tests. Individuals were free of CVD at the time of recruitment. Individuals with resting SBP ≥160 mm Hg or DBP ≥100 mm Hg or taking antihypertensive drug therapy were excluded from the study. The association between resting plasma protein levels to both resting BP and EBP was evaluated. Proteins associated with EBP were analyzed for their association with incident hypertension in the Framingham Heart Study (FHS; n = 1177) and validated in the Jackson Heart Study (JHS; n = 772) and Multi-Ethnic Study of Atherosclerosis (MESA; n = 1367). Proteins associated with incident hypertension were tested for putative causal links in approximately 700 000 individuals using cis-protein quantitative loci mendelian randomization (cis-MR). Data were analyzed from January 2023 to January 2024. EXPOSURES: Plasma proteins. MAIN OUTCOMES AND MEASURES: EBP was defined as the BP response during a fixed workload (50 W) on a cycle ergometer. Hypertension was defined as BP ≥140/90 mm Hg or taking antihypertensive medication. RESULTS: Among the 681 participants in the HERITAGE Family Study, the mean (SD) age was 34 (13) years; 366 participants (54%) were female; 238 (35%) were self-reported Black and 443 (65%) were self-reported White. Proteomic profiling of EBP revealed 34 proteins that would not have otherwise been identified through profiling of resting BP alone. Transforming growth factor β receptor 3 (TGFBR3) and prostaglandin D2 synthase (PTGDS) had the strongest association with exercise systolic BP (SBP) and diastolic BP (DBP), respectively (TGFBR3: exercise SBP, β estimate, −3.39; 95% CI, −4.79 to −2.00; P = 2.33 × 10−6; PTGDS: exercise DBP β estimate, −2.50; 95% CI, −3.29 to −1.70; P = 1.18 × 10−9). In fully adjusted models, TGFBR3 was inversely associated with incident hypertension in FHS, JHS, and MESA (hazard ratio [HR]: FHS, 0.86; 95% CI, 0.75-0.97; P = .01; JHS, 0.87; 95% CI, 0.77-0.97; P = .02; MESA, 0.84; 95% CI, 0.71-0.98; P = .03; pooled cohort, 0.86; 95% CI, 0.79-0.92; P = 6 × 10−5). Using cis-MR, genetically predicted levels of TGFBR3 were associated with SBP, hypertension, and CVD events (SBP: β, −0.38; 95% CI, −0.64 to −0.11; P = .006; hypertension: odds ratio [OR], 0.99; 95% CI, 0.98-0.99; P < .001; heart failure with hypertension: OR, 0.86; 95% CI, 0.77-0.97; P = .01; CVD: OR, 0.84; 95% CI, 0.77-0.92; P = 8 × 10−5; cerebrovascular events: OR, 0.77; 95% CI, 0.70-0.85; P = 5 × 10−7). CONCLUSIONS AND RELEVANCE: Plasma proteomic profiling of EBP identified a novel protein, TGFBR3, which may protect against elevated BP and long-term CVD outcomes.

Published
2024
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109. Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD

Author

Ganda, Anjali, Yvan-Charvet, Laurent, Zhang, Yuan, Lai, Eric J., Regunathan-Shenk, Renu, Hussain, Farah N., Avasare, Rupali, Chakraborty, Bibhas, Febus, Annie J., Vernocchi, Linda, Lantigua, Rafael, Wang, Ying, Shi, Xu, Hsieh, Joanne, Murphy, Andrew J., Wang, Nan, Bijl, Nora, Gordon, Kristie M., de Miguel, Maria Hamm, Singer, Jessica R., Hogan, Jonathan, Cremers, Serge, Magnusson, Martin, Melander, Olle, Gerszten, Robert E., and Tall, Alan R.

Published
2017
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111. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Author

Warren, Curtis R., O’Sullivan, John F., Friesen, Max, Becker, Caroline E., Zhang, Xiaoling, Liu, Poching, Wakabayashi, Yoshiyuki, Morningstar, Jordan E., Shi, Xu, Choi, Jihoon, Xia, Fang, Peters, Derek T., Florido, Mary H.C., Tsankov, Alexander M., Duberow, Eilene, Comisar, Lauren, Shay, Jennifer, Jiang, Xin, Meissner, Alexander, Musunuru, Kiran, Kathiresan, Sekar, Daheron, Laurence, Zhu, Jun, Gerszten, Robert E., Deo, Rahul C., Vasan, Ramachandran S., O’Donnell, Christopher J., and Cowan, Chad A.

Published
2017
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112. The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Author

Bennett, J. Allen, Mastrangelo, Michael A., Ture, Sara K., Smith, Charles O., Loelius, Shannon G., Berg, Rachel A., Shi, Xu, Burke, Ryan M., Spinelli, Sherry L., Cameron, Scott J., Carey, Thomas E., Brookes, Paul S., Gerszten, Robert E., Sabater-Lleal, Maria, de Vries, Paul S., Huffman, Jennifer E., Smith, Nicholas L., Morrell, Craig N., and Lowenstein, Charles J.

Published
2020
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113. Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study

Author

Tahir, Usman A., Katz, Daniel H., Zhao, Tianyi, Ngo, Debby, Cruz, Daniel E., Robbins, Jeremy M., Chen, Zsu-Zsu, Peterson, Bennet, Benson, Mark D., Shi, Xu, Dailey, Lucas, Andersson, Charlotte, Vasan, Ramachandran S., Gao, Yan, Shen, Changyu, Correa, Adolfo, Hall, Michael E., Wang, Thomas J., Clish, Clary B., Wilson, James G., and Gerszten, Robert E.

Published
2021
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115. Abstract 13944: Biracial Proteomic Profiling Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Individuals

Author

Katz, Daniel H, Tahir, Usman A, Ngo, Debby, Benson, Mark, Gao, Yan, shi, xu, Nayor, Matthew G, Keyes, Michelle J, Larson, Martin G, Hall, Michael E, Correa, Adolfo, Sinha, Sumita, Shen, Dongxiao, Herzig, Matthew, Yang, Qiong, ROBBINS, Jeremy M, Chen, Zsu-Zsu, Cruz, Daniel E, Peterson, Bennet, Ramachandran, Vasan S, Wang, Thomas J, and GERSZTEN, Robert E

Published
2020
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118. Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits

Author

Nayor, Matthew, Short, Meghan I., Rasheed, Humaira, Lin, Honghuang, Jonasson, Christian, Yang, Qiong, Hveem, Kristian, Felix, Janine F., Morrison, Alanna C., Wild, Philipp S., Morley, Michael P., Cappola, Thomas P., Benson, Mark D., Ngo, Debby, Sinha, Sumita, Keyes, Michelle J., Shen, Dongxiao, Wang, Thomas J., Larson, Martin G., Brumpton, Ben M., Gerszten, Robert E., Omland, Torbjørn, and Vasan, Ramachandran S.

Published
2020
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120. Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies

Author

Zhang, Daiwei, primary, Gao, Boran, additional, Feng, Qidi, additional, Manichaikul, Ani W., additional, Peloso, Gina M., additional, Tracy, Russell, additional, Durda, Peter, additional, Taylor, Kent, additional, Liu, Yongmei, additional, Johnson, W. Craig, additional, Gabriel, Stacey, additional, Gupta, Namrata, additional, Smith, Joshua D., additional, Aguet, Francois, additional, Ardlie, Kristin G., additional, Blackwell, Thomas W., additional, Gerszten, Robert E., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Scott, Laura, additional, Zhou, Xiang, additional, and Lee, Seunggeun, additional

Published
2023
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121. The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes

Author

Ha, Edward T., primary, Taylor, Kent D., additional, Raffield, Laura M, additional, Briggs, William M, additional, Yee, Aaron, additional, Elemento, Olivier, additional, Parikh, Manish A., additional, Peterson, Stephen J, additional, Frishman, William, additional, Gerszten, Robert E, additional, Wilson, James G., additional, Kelsey, Karl T., additional, Tahir, Usman A., additional, Reiner, Alexander P., additional, Auer, Paul, additional, Seeman, Teresa E., additional, Rich, Stephen S. S., additional, Carson, April P., additional, Post, Wendy S., additional, Rotter, Jerome I. I., additional, and Aronow, Wilbert S., additional

Published
2023
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122. Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait

Author

Cai, Yanwei, primary, Franceschini, Nora, additional, Surapaneni, Aditya, additional, Garrett, Melanie E., additional, Tahir, Usman A., additional, Hsu, Li, additional, Telen, Marilyn J., additional, Yu, Bing, additional, Tang, Hua, additional, Li, Yun, additional, Liu, Simin, additional, Gerszten, Robert E., additional, Coresh, Josef, additional, Manson, JoAnn E., additional, Wojcik, Genevieve L., additional, Kooperberg, Charles, additional, Auer, Paul L., additional, Foster, Matthew W., additional, Grams, Morgan E., additional, Ashley-Koch, Allison E., additional, Raffield, Laura M., additional, and Reiner, Alex P., additional

Published
2023
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123. Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts

Author

Ngo, Debby, primary, Pratte, Katherine A., additional, Flexeder, Claudia, additional, Petersen, Hans, additional, Dang, Hong, additional, Ma, Yanlin, additional, Keyes, Michelle J., additional, Gao, Yan, additional, Deng, Shuliang, additional, Peterson, Bennet D., additional, Farrell, Laurie A., additional, Bhambhani, Victoria M., additional, Palacios, Cesar, additional, Quadir, Juweria, additional, Gillenwater, Lucas, additional, Xu, Hanfei, additional, Emson, Claire, additional, Gieger, Christian, additional, Suhre, Karsten, additional, Graumann, Johannes, additional, Jain, Deepti, additional, Conomos, Matthew P., additional, Tracy, Russell P., additional, Guo, Xiuqing, additional, Liu, Yongmei, additional, Johnson, W. Craig, additional, Cornell, Elaine, additional, Durda, Peter, additional, Taylor, Kent D., additional, Papanicolaou, George J., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Rennard, Steven I., additional, Curtis, Jeffrey L., additional, Woodruff, Prescott G., additional, Comellas, Alejandro P., additional, Silverman, Edwin K., additional, Crapo, James D., additional, Larson, Martin G., additional, Vasan, Ramachandran S., additional, Wang, Thomas J., additional, Correa, Adolfo, additional, Sims, Mario, additional, Wilson, James G., additional, Gerszten, Robert E., additional, O’Connor, George T., additional, Barr, R. Graham, additional, Couper, David, additional, Dupuis, Josée, additional, Manichaikul, Ani, additional, O’Neal, Wanda K., additional, Tesfaigzi, Yohannes, additional, Schulz, Holger, additional, and Bowler, Russell P., additional

Published
2023
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124. Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion

Author

Martí-Pàmies, Íngrid, primary, Thoonen, Robrecht, additional, Morley, Michael, additional, Graves, Lauren, additional, Tamez, Jesus, additional, Caplan, Alex, additional, McDaid, Kendra, additional, Yao, Vincent, additional, Hindle, Allyson, additional, Gerszten, Robert E., additional, Farrell, Laurie A., additional, Li, Li, additional, Tseng, Yu-Hua, additional, Profeta, Gerson, additional, Buys, Emmanuel S., additional, Bloch, Donald B., additional, and Scherrer-Crosbie, Marielle, additional

Published
2023
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125. Metabolic Signatures of Cardiac Dysfunction, Multimorbidity, and Post–Transcatheter Aortic Valve Implantation Death

Author

Perry, Andrew S., primary, Zhao, Shilin, additional, Murthy, Venkatesh, additional, Gupta, Deepak K., additional, Fearon, William F., additional, Kim, Juyong B., additional, Kapadia, Samir, additional, Kumbhani, Dharam J., additional, Gillam, Linda, additional, Whisenant, Brian, additional, Quader, Nishath, additional, Zajarias, Alan, additional, Mallugari, Ravinder R., additional, Clark, Daniel E., additional, Patel, Jay N., additional, Gonzales, Holly, additional, Welt, Frederick G., additional, Bavry, Anthony A., additional, Coylewright, Megan, additional, Piana, Robert N., additional, Vatterott, Anna, additional, Jackson, Natalie, additional, Gerszten, Robert E., additional, Lindman, Brian R., additional, Shah, Ravi, additional, and Elmariah, Sammy, additional

Published
2023
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126. Author Correction: Human plasma proteomic profiles indicative of cardiorespiratory fitness

Author

Robbins, Jeremy M., Peterson, Bennet, Schranner, Daniela, Tahir, Usman A., Rienmüller, Theresa, Deng, Shuliang, Keyes, Michelle J., Katz, Daniel H., Beltran, Pierre M. Jean, Barber, Jacob L., Baumgartner, Christian, Carr, Steven A., Ghosh, Sujoy, Shen, Changyu, Jennings, Lori L., Ross, Robert, Sarzynski, Mark A., Bouchard, Claude, and Gerszten, Robert E.

Published
2021
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128. Molecular Biomarkers for Cardiometabolic Disease: Risk Assessment in Young Individuals

Author

Tahir, Usman A. and Gerszten, Robert E.

Subjects
Article
Abstract

Cardiometabolic diseases, including cardiovascular disease and diabetes, are major causes of morbidity and mortality worldwide. Despite progress in prevention and treatment, recent trends show a stalling in the reduction of cardiovascular disease morbidity and mortality, paralleled by increasing rates of cardiometabolic disease risk factors in young adults, underscoring the importance of risk assessments in this population. This review highlights the evidence for molecular biomarkers for early risk assessment in young individuals. We examine the utility of traditional biomarkers in young individuals and discuss novel, nontraditional biomarkers specific to pathways contributing to early cardiometabolic disease risk. Additionally, we explore emerging omic technologies and analytical approaches that could enhance risk assessment for cardiometabolic disease.

Published
2023

132. Plasma Proteomic Associations With Incident Ischemic Stroke in Older Adults

Author

Kalani, Rizwan, primary, Bartz, Traci M., additional, Psaty, Bruce M., additional, Elkind, Mitchell S.V., additional, Floyd, James S., additional, Gerszten, Robert E., additional, Shojaie, Ali, additional, Heckbert, Susan R., additional, Bis, Joshua C., additional, Austin, Thomas R., additional, Tirschwell, David L., additional, Delaney, Joseph A.C., additional, and Longstreth, W.T., additional

Published
2023
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133. Abstract 679: HDL Apolipoproteomic Score, Cardiometabolic Risk, And Exercise Training

Author

Miranda Maravi, Juan S, primary, Schwartz, Charles S, additional, Dev, Prasun K, additional, Barber, Jacob L, additional, Reasons, Riley J, additional, Pearce, Ryan W, additional, Mcphaul, Michael J, additional, Gerszten, Robert E, additional, Rohatgi, Anand, additional, Bouchard, Claude, additional, Collier, Timothy S, additional, and Sarzynski, Mark A, additional

Published
2023
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134. Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations

Author

Robbins, Jeremy M., primary, Rao, Prashant, additional, Deng, Shuliang, additional, Keyes, Michelle J., additional, Tahir, Usman A., additional, Katz, Daniel H., additional, Beltran, Pierre M. Jean, additional, Marchildon, François, additional, Barber, Jacob L., additional, Peterson, Bennet, additional, Gao, Yan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Smith, J. Gustav, additional, Cohen, Paul, additional, Ross, Robert, additional, Bouchard, Claude, additional, Sarzynski, Mark A., additional, and Gerszten, Robert E., additional

Published
2023
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135. Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome

Author

Wang, Suya, primary, Yazawa, Erika, additional, Keating, Erin, additional, Mazumdar, Neil, additional, Hauschild, Alexander, additional, Ma, Qing, additional, Wu, Haiyan, additional, Xu, Yang, additional, Shi, Xu, additional, Strathdee, Douglas, additional, Gerszten, Robert E, additional, Schlame, Michael, additional, and Pu, William T, additional

Published
2023
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136. CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

Author

Tanzo, Julia T., primary, Li, Veronica L., additional, Wiggenhorn, Amanda L., additional, Moya-Garzon, Maria Dolores, additional, Wei, Wei, additional, Lyu, Xuchao, additional, Dong, Wentao, additional, Tahir, Usman A., additional, Chen, Zsu-Zsu, additional, Cruz, Daniel E., additional, Deng, Shuliang, additional, Shi, Xu, additional, Zheng, Shuning, additional, Guo, Yan, additional, Sims, Mario, additional, Abu-Remaileh, Monther, additional, Wilson, James G., additional, Gerszten, Robert E., additional, Long, Jonathan Z., additional, and Benson, Mark D., additional

Published
2023
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137. Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization

Author

Bersell, Kevin R., primary, Yang, Tao, additional, Mosley, Jonathan D., additional, Glazer, Andrew M., additional, Hale, Andrew T., additional, Kryshtal, Dmytro O., additional, Kim, Kyungsoo, additional, Steimle, Jeffrey D., additional, Brown, Jonathan D., additional, Salem, Joe-Elie, additional, Campbell, Courtney C., additional, Hong, Charles C., additional, Wells, Quinn S., additional, Johnson, Amanda N., additional, Short, Laura, additional, Blair, Marcia A., additional, Behr, Elijah R., additional, Petropoulou, Evmorfia, additional, Jamshidi, Yalda, additional, Benson, Mark D., additional, Keyes, Michelle J., additional, Ngo, Debby, additional, Vasan, Ramachandran S., additional, Yang, Qiong, additional, Gerszten, Robert E., additional, Shaffer, Christian, additional, Parikh, Shan, additional, Sheng, Quanhu, additional, Kannankeril, Prince J., additional, Moskowitz, Ivan P., additional, York, John D., additional, Wang, Thomas J., additional, Knollmann, Bjorn C., additional, and Roden, Dan M., additional

Published
2023
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138. METABOLIC SIGNATURES OF CARDIAC DYSFUNCTION ARE ASSOCIATED WITH MULTIMORBIDITY AND POST-TRANSCATHETER AORTIC VALVE IMPLANTATION MORTALITY

Author

Perry, Andrew, primary, Zhao, Shilin, additional, Murthy, Venkatesh Locharla, additional, Gupta, Deepak K., additional, Fearon, William Fuller, additional, Kim, Juyong Brian, additional, Kapadia, Samir R., additional, Kumbhani, Dharam J., additional, Gillam, Linda D., additional, Whisenant, Brian K., additional, Quader, Nishath, additional, Zajarias, Alan, additional, Mallugari, Ravinder, additional, Clark, Daniel Eugene, additional, Patel, Jay, additional, Gonzales, Holly, additional, Welt, Frederick G.P., additional, Bavry, Anthony A., additional, Coylewright, Megan, additional, Piana, Robert N., additional, Jackson, Natalie, additional, Gerszten, Robert E., additional, Lindman, Brian R., additional, Shah, Ravi, additional, and Elmariah, Sammy, additional

Published
2023
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139. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

Author

Tateishi, Kensuke, Wakimoto, Hiroaki, Iafrate, A. John, Tanaka, Shota, Loebel, Franziska, Lelic, Nina, Wiederschain, Dmitri, Bedel, Olivier, Deng, Gejing, Zhang, Bailin, He, Timothy, Shi, Xu, Gerszten, Robert E., Zhang, Yiyun, Yeh, Jing-Ruey J., Curry, William T., Zhao, Dan, Sundaram, Sudhandra, Nigim, Fares, Koerner, Mara V.A., Ho, Quan, Fisher, David E., Roider, Elisabeth M., Kemeny, Lajos V., Samuels, Yardena, Flaherty, Keith T., Batchelor, Tracy T., Chi, Andrew S., and Cahill, Daniel P.

Published
2015
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141. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

Author

O'Sullivan, John F., Morningstar, Jordan E., Yang, Qiong, Zheng, Baohui, Gao, Yan, Jeanfavre, Sarah, Fernandez, Celine, Scott, Justin, Zheng, Hui, OConnor, Sean, Cohen, Paul, Vasan, Ramachandran S., Long, Michelle T., Wilson, James G., Melander, Olle, Wang, Thomas J., Fox, Caroline, Peterson, Randall T., Clish, Clary B., Corey, Kathleen E., and Gerszten, Robert E.

Subjects
Obesity -- Risk factors, Diabetes mellitus -- Risk factors, Liver diseases -- Risk factors, Dyslipidemias -- Risk factors, Health care industry
Abstract

Unbiased, 'nontargeted' metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CTdefined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases., Introduction Nonalcoholic fatty liver disease (NAFLD) is defined by the presence of hepatic steatosis (via histology or imaging) when there are no causes for secondary hepatic fat accumulation, and it [...]

Published
2017
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142. Canonical correlation analysis for multi-omics: Application to cross-cohort analysis

Author

Tracy, Russell P., VanDenBerg, David J., Smith, Josh, Sofer, Tamar, Liu, Yongmei, Durda, Peter, Rich, Stephen S., Rotter, Jerome I., Kasela, Silva, Lappalainen, Tuuli, Love, Michael I., Gabriel, Stacey B., Chen, Jiawen, Cruz, Dan, Ardlie, Kristin, Taylor, Kent D., Gerszten, Robert E., Johnson, Craig W., Raffield, Laura M., Reiner, Alex P., Wilson, James G., Lange, Leslie A., Guo, Xiuqing, Cornell, Elaine, Aguet, François, Jiang, Min-Zhi, Li, Yun, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group, and Le Cao, Kim-Anh

Subjects
Cohort Studies, Proteomics, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Canonical Correlation Analysis, Human Genome, Genetics, TOPMed Analysis Working Group, Humans, Generic health relevance, Multiomics, Cardiovascular, Biotechnology, Developmental Biology
Abstract

Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of multiple or all components in a biological system of interest. Canonical correlation analysis (CCA) is a correlation-based integrative method designed to extract latent features shared between multiple assays by finding the linear combinations of features–referred to as canonical variables (CVs)–within each assay that achieve maximal across-assay correlation. Although widely acknowledged as a powerful approach for multi-omics data, CCA has not been systematically applied to multi-omics data in large cohort studies, which has only recently become available. Here, we adapted sparse multiple CCA (SMCCA), a widely-used derivative of CCA, to proteomics and methylomics data from the Multi-Ethnic Study of Atherosclerosis (MESA) and Jackson Heart Study (JHS). To tackle challenges encountered when applying SMCCA to MESA and JHS, our adaptations include the incorporation of the Gram-Schmidt (GS) algorithm with SMCCA to improve orthogonality among CVs, and the development of Sparse Supervised Multiple CCA (SSMCCA) to allow supervised integration analysis for more than two assays. Effective application of SMCCA to the two real datasets reveals important findings. Applying our SMCCA-GS to MESA and JHS, we identified strong associations between blood cell counts and protein abundance, suggesting that adjustment of blood cell composition should be considered in protein-based association studies. Importantly, CVs obtained from two independent cohorts also demonstrate transferability across the cohorts. For example, proteomic CVs learned from JHS, when transferred to MESA, explain similar amounts of blood cell count phenotypic variance in MESA, explaining 39.0% ~ 50.0% variation in JHS and 38.9% ~ 49.1% in MESA. Similar transferability was observed for other omics-CV-trait pairs. This suggests that biologically meaningful and cohort-agnostic variation is captured by CVs. We anticipate that applying our SMCCA-GS and SSMCCA on various cohorts would help identify cohort-agnostic biologically meaningful relationships between multi-omics data and phenotypic traits.

Published
2023

143. Abstract P201: Plasma Proteomic Signatures of Angptl3/8 and 4/8 Before and After Exercise Training

Author

Miranda-Maravi, Sebastian, primary, Hoffman, William G, additional, Dev, Prasun K, additional, Barber, Jacob L, additional, Schwartz, Charles S, additional, Clarkson, William A, additional, Robbins, Jeremy M, additional, Rao, Prashant, additional, Mi, Michael, additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Silbernagel, Gunther, additional, Chen, Yan Q, additional, Konrad, Robert J, additional, Bouchard, Claude, additional, Gerszten, Robert E, additional, and Sarzynski, Mark A, additional

Published
2023
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144. Abstract P205: Association of Angptl3/8 and 4/8 With Plasma Metabolites Before and After Exercise Training

Author

Dev, Prasun K, primary, Miranda-Maravi, Sebastian, additional, Hoffman, William, additional, Barber, Jacob L, additional, Schwartz, Charles S, additional, Clarkson, William A, additional, Robbins, Jeremy M, additional, Rao, Prashant, additional, Mi, Michael, additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Silbernagel, Gunther, additional, Chen, Yan Q, additional, Konrad, Robert J, additional, Bouchard, Claude, additional, Gerszten, Robert E, additional, and Sarzynski, Mark A, additional

Published
2023
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145. Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis

Author

Cronjé, Héléne T., primary, Mi, Michael Y., primary, Austin, Thomas R., primary, Biggs, Mary L., primary, Siscovick, David S., primary, Lemaitre, Rozenn N., primary, Psaty, Bruce M., primary, Tracy, Russell P., primary, Djoussé, Luc, primary, Kizer, Jorge R., primary, Ix, Joachim H., primary, Rao, Prashant, primary, Robbins, Jeremy M., primary, Barber, Jacob L., primary, Sarzynski, Mark A., primary, Clish, Clary B., primary, Bouchard, Claude, primary, Mukamal, Kenneth J., primary, Gerszten, Robert E., primary, and Jensen, Majken K., primary

Published
2023
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146. Abstract WMP101: Plasma Proteomic Determinants Of White Matter Hyperintensities And Covert Brain Infarction In The Cardiovascular Health Study

Author

Sharma, Malveeka, primary, Longstreth, W T, additional, Kalani, Rizwan, additional, Psaty, Bruce, additional, Elkind, Mitchell, additional, Floyd, James S, additional, Heckbert, Susan R, additional, Buckwalter, Marion S, additional, Gomez, Gabriela, additional, Walker, Keenan, additional, Bartz, Traci, additional, Austin, Thomas, additional, Bis, Joshua, additional, Brody, Jennifer, additional, Tirschwell, David L, additional, Tracy, Russell P, additional, Gerszten, Robert E, additional, and Fohner, Alison, additional

Published
2023
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147. Protein markers of diabetes discovered in an African American cohort

Author

Chen, Zsu-Zsu, primary, Gao, Yan, primary, Keyes, Michelle J., primary, Deng, Shuliang, primary, Mi, Michael, primary, Farrell, Laurie A., primary, Shen, Dongxiao, primary, Tahir, Usman A., primary, Cruz, Daniel E., primary, Ngo, Debby, primary, Benson, Mark D., primary, Robbins, Jeremy M., primary, Correa, Adolfo, primary, Wilson, James G., primary, and Gerszten, Robert E., primary

Published
2023
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148. Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice

Author

Liu, Jing, primary, Lane, Sarah, additional, Lall, Rahul, additional, Russo, Michele, additional, Farrell, Laurie, additional, Debreli Coskun, Melis, additional, Curtin, Casie, additional, Araujo-Gutierrez, Raquel, additional, Scherrer-Crosbie, Marielle, additional, Trachtenberg, Barry H., additional, Kim, Jonghan, additional, Tolosano, Emanuela, additional, Ghigo, Alessandra, additional, Gerszten, Robert E., additional, and Asnani, Aarti, additional

Published
2022
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150. Probing the Virtual Proteome to Identify Novel Disease Biomarkers

Author

Mosley, Jonathan D., Benson, Mark D., Smith, J. Gustav, Melander, Olle, Ngo, Debby, Shaffer, Christian M., Ferguson, Jane F., Herzig, Matthew S., McCarty, Catherine A., Chute, Christopher G., Jarvik, Gail P., Gordon, Adam S., Palmer, Melody R., Crosslin, David R., Larson, Eric B., Carrell, David S., Kullo, Iftikhar J., Pacheco, Jennifer A., Peissig, Peggy L., Brilliant, Murray H., Kitchner, Terrie E., Linneman, James G., Namjou, Bahram, Williams, Marc S., Ritchie, Marylyn D., Borthwick, Kenneth M., Kiryluk, Krzysztof, Mentch, Frank D., Sleiman, Patrick M., Karlson, Elizabeth W., Verma, Shefali S., Zhu, Yineng, Vasan, Ramachandran S., Yang, Qiong, Denny, Josh C., Roden, Dan M., Gerszten, Robert E., and Wang, Thomas J.

Published
2018
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