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101. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91

Author

von Hoff, K, Hinkes, B, Gerber, N U, Deinlein, F, Mittler, U, Urban, C, Benesch, M, Warmuth-Metz, M, Soerensen, N, Zwiener, I, Goette, H, Schlegel, P G, Pietsch, T, Kortmann, R D, Kuehl, J, Rutkowski, S, University of Zurich, and Rutkowski, S

Subjects
10036 Medical Clinic, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2009
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102. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

Author

Pfister, S, Remke, M, Benner, A, Mendrzyk, F, Toedt, G, Felsberg, J, Wittmann, A, Devens, F, Gerber, N U, Joos, S, Kulozik, A, Reifenberger, G, Rutkowski, S, Wiestler, O D, Radlwimmer, B, Scheurlen, W, Lichter, P, Korshunov, A, University of Zurich, and Pfister, S

Subjects
10036 Medical Clinic, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2009

114. EPENDYMOMA

Author

Hoffman, L. M., primary, Donson, A. M., additional, Nakachi, I., additional, Griesinger, A. M., additional, Birks, D. K., additional, Amani, V., additional, Hemenway, M. S., additional, Liu, A. K., additional, Wang, M., additional, Hankinson, T. C., additional, Handler, M. H., additional, Foreman, N. K., additional, Zakrzewska, M., additional, Zakrzewski, K., additional, Fendler, W., additional, Stefanczyk, L., additional, Liberski, P. P., additional, Massimino, M., additional, Gandola, L., additional, Ferroli, P., additional, Valentini, L., additional, Biassoni, V., additional, Garre, M. L., additional, Sardi, I., additional, Genitori, L., additional, Giussani, C., additional, Massimi, L., additional, Bertin, D., additional, Mussano, A., additional, Viscardi, E., additional, Modena, P., additional, Mastronuzzi, A., additional, Barra, S., additional, Scarzello, G., additional, Cinalli, G., additional, Peretta, P., additional, Giangaspero, F., additional, Boschetti, L., additional, Schiavello, E., additional, Calareso, G., additional, Antonelli, M., additional, Pecori, E., additional, Di Meco, F., additional, Migliorati, R., additional, Taborelli, A., additional, Witt, H., additional, Sill, M., additional, Wani, K., additional, Mack, S. C., additional, Capper, D., additional, Pajtler, K., additional, Lambert, S., additional, Tzaridis, T., additional, Milde, T., additional, Northcott, P. A., additional, Kulozik, A. E., additional, Witt, O., additional, Collins, V. P., additional, Ellison, D. W., additional, Taylor, M. D., additional, Kool, M., additional, Jones, D. T. W., additional, Korshunov, A., additional, Ken, A., additional, Pfister, S. M., additional, Makino, K., additional, Nakamura, H., additional, Kuroda, J.-i., additional, Kuratsu, J.-i., additional, Toledano, H., additional, Margolin, Y., additional, Ohali, A., additional, Michowiz, S., additional, Johann, P., additional, Tabori, U., additional, Walker, E., additional, Hawkins, C., additional, Taylor, M., additional, Yaniv, I., additional, Avigad, S., additional, Hoffman, L., additional, Plimpton, S. R., additional, Stence, N. V., additional, Vibhakar, R., additional, Lourdusamy, A., additional, Rahman, R., additional, Ward, J., additional, Rogers, H., additional, Grundy, R., additional, Punchihewa, C., additional, Lee, R., additional, Lin, T., additional, Orisme, W., additional, Dalton, J., additional, Aronica, E., additional, Smith, A., additional, Gajjar, A., additional, Onar, A., additional, Pounds, S., additional, Tatevossian, R., additional, Merchant, T., additional, Ellison, D., additional, Parker, M., additional, Mohankumar, K., additional, Weinlich, R., additional, Phoenix, T., additional, Thiruvenkatam, R., additional, White, E., additional, Gupta, K., additional, Boop, F., additional, Ding, L., additional, Mardis, E., additional, Wilson, R., additional, Downing, J., additional, Gilbertson, R., additional, Speed, D., additional, Gould, T., additional, Consortium, t. I. E., additional, Hoffman, L. M., additional, Griesinger, A., additional, Donson, A., additional, Birks, D., additional, Ohe, N., additional, Yano, H., additional, Nakayama, N., additional, Iwama, T., additional, Wright, K., additional, Hassall, T., additional, Bowers, D. C., additional, Crawford, J., additional, Bendel, A., additional, Fisher, P. G., additional, Klimo, P., additional, Armstrong, G., additional, Qaddoumi, I., additional, Robinson, G., additional, Wetmore, C., additional, Broniscer, A., additional, Chapman, R., additional, Mayne, C., additional, Duane, H., additional, Kilday, J.-P., additional, Coyle, B., additional, Graul-Conroy, A., additional, Hartsell, W., additional, Bragg, T., additional, Goldman, S., additional, Rebsamen, S., additional, Puccetti, D., additional, Salamat, S., additional, Patel, N. J., additional, Gomi, A., additional, Oguma, H., additional, Hayase, T., additional, Kawahara, Y., additional, Yagi, M., additional, Morimoto, A., additional, Wilbur, C., additional, Dunham, C., additional, Mabbott, D., additional, Carret, A.-S., additional, Lafay-Cousin, L., additional, McNeely, P. D., additional, Eisenstat, D., additional, Wilson, B., additional, Johnston, D., additional, Hukin, J., additional, Mynarek, M., additional, Kortmann, R. D., additional, Kaatsch, P., additional, Pietsch, T., additional, Timmermann, B., additional, Fleischhack, G., additional, Benesch, M., additional, Friedrich, C., additional, von Bueren, A. O., additional, Gerber, N. U., additional, Muller, K., additional, Tippelt, S., additional, Warmuth-Metz, M., additional, Rutkowski, S., additional, von Hoff, K., additional, Murugesan, M. K., additional, Poppleton, H., additional, Currle, S., additional, Kranenburg, T., additional, Eden, C., additional, Boulos, N., additional, Dapper, J., additional, Patel, Y., additional, Freeman, B., additional, Shelat, A., additional, Stewart, C., additional, Guy, R., additional, Adamski, J., additional, Huang, A., additional, Bartels, U., additional, Ramaswamy, V., additional, Krishnatry, R., additional, Laperriere, N., additional, Bouffet, E., additional, Araki, A., additional, Chocholous, M., additional, Gojo, J., additional, Dorfer, C., additional, Czech, T., additional, Dieckmann, K., additional, Slavc, I., additional, Haberler, C., additional, Doerner, E., additional, Muehlen, A. z., additional, Kortmann, R., additional, von Buehren, A., additional, Ottensmeier, H., additional, Resch, A., additional, Kwiecien, R., additional, Faldum, A., additional, Kuehl, J., additional, Sabnis, D., additional, Storer, L., additional, Simmonds, L., additional, Blackburn, S., additional, Lowe, J., additional, Kerr, I., additional, Wohlers, I., additional, Goschzik, T., additional, Dreschmann, V., additional, Denkhaus, D., additional, Rahmann, S., additional, Klein-Hitpass, L., additional, Iglesias, M. J. L., additional, Riet, F. G., additional, Dhermain, F. D., additional, Canale, S., additional, Dufour, C., additional, Rose, C. S., additional, Puget, S., additional, Grill, J., additional, Bolle, S., additional, Parkes, J., additional, Davidson, A., additional, Figaji, A., additional, Pillay, K., additional, Kilborn, T., additional, Padayachy, L., additional, Hendricks, M., additional, Van Eyssen, A., additional, Piccinin, E., additional, Lorenzetto, E., additional, Brenca, M., additional, Aldape, K., additional, Cho, Y.-J., additional, Weiss, W., additional, Phillips, J., additional, Jabado, N., additional, Mora, J., additional, Fan, X., additional, Jung, S., additional, Lee, J. Y., additional, Zitterbart, K., additional, French, P., additional, Kros, J. M., additional, Hauser, P., additional, Faria, C., additional, and Pfister, S., additional

Published
2014
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115. NEUROSURGERY

Author

Charalampaki, C., primary, Eyth, C., additional, Morgan, M., additional, Charalampaki, C., additional, Ogiwara, H., additional, Kiyotani, C., additional, Terashima, K., additional, Morota, N., additional, Igressa, A., additional, Pettorini, B., additional, Pizer, B., additional, Kanwar, A., additional, Avula, S., additional, Mallucci, C., additional, Leroy, H.-A., additional, Baroncini, M., additional, Delestret, I., additional, Vinchon, M., additional, Kato, T., additional, Hankinson, T., additional, Dudley, R., additional, Poonia, S., additional, Torok, M., additional, Handler, M., additional, Liu, A., additional, Harter, D., additional, Karajanis, M., additional, Wisoff, J., additional, Weiner, H., additional, Toidze, I., additional, Tsikarishvili, V., additional, Lobjanidze, N., additional, Elizbarashvili, I., additional, Akiashvili, N., additional, Maisuradze, T., additional, Jaiswal, A., additional, Jaiswal, S., additional, Mehrotra, A., additional, Srivastava, A., additional, Sahu, R., additional, Behari, S., additional, Behari;, S., additional, Curry, D., additional, Honeycutt, J., additional, O'Neill, B., additional, George, T., additional, Gerber, N. U., additional, Muller, A., additional, Bozinov, O., additional, Berger, C., additional, Grotzer, M. A., additional, Kamaly-Asl, I., additional, Alston, R., additional, McCabe, M., additional, Birch, J., additional, Gattamaneni, R., additional, Estlin, E., additional, Coelho, G., additional, Kunsler, F., additional, Lessa, L., additional, Epelman, S., additional, and Zanon, N., additional

Published
2014
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116. Transcriptional diversity of long-term glioblastoma survivors

Author

Gerber, N. K., primary, Goenka, A., additional, Turcan, S., additional, Reyngold, M., additional, Makarov, V., additional, Kannan, K., additional, Beal, K., additional, Omuro, A., additional, Yamada, Y., additional, Gutin, P., additional, Brennan, C. W., additional, Huse, J. T., additional, and Chan, T. A., additional

Published
2014
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117. Validity and use of the UV index: report from the UVI working group, Schloss Hohenkammer, Germany, 5-7 December 2011.

Author

Allinson, Sarah, Asmuss, M, Baldermann, C, Bentzen, J, Buller, D, Gerber, N, Green, AC, Greinert, R, Kimlin, M, Kunrath, J, Matthes, R, Pölzl-Viol, C, Rehfuess, E, Ziegelberger, G, Allinson, Sarah, Asmuss, M, Baldermann, C, Bentzen, J, Buller, D, Gerber, N, Green, AC, Greinert, R, Kimlin, M, Kunrath, J, Matthes, R, Pölzl-Viol, C, Rehfuess, E, and Ziegelberger, G

Published
2012

118. Single- and multiple-dose pharmacokinetics of ziprasidone under non-fasting conditions in healthy male volunteers

Author

Miceli, J J, Wilner, K D, Hansen, R A, Johnson, A C, Apseloff, G, and Gerber, N

Subjects
Adult, Male, Adolescent, Middle Aged, Piperazines, Prolactin, Thiazoles, Double-Blind Method, Reference Values, Area Under Curve, Humans, Sleep Stages, Sleep, Supplement, Antipsychotic Agents
Abstract

To evaluate the pharmacokinetics and tolerability of single and multiple oral doses of ziprasidone in healthy male volunteers, and to determine the influence of ziprasidone on serum prolactin levels.Single and multiple doses of ziprasidone were given orally (as two divided daily doses), at fixed dosages of 10 and 40 mg day(-1), and using titrated regimens of 40-80 and 40-120 mg day(-1), for 14 days. All dosages were taken immediately after food. The study adopted a randomized, double-blind, placebo-controlled design. Prolactin response, sedative properties, tolerability, and extrapyramidal symptoms were also investigated.Steady-state exposure to ziprasidone was attained after 1 day of dosing. Mean Cmax and AUC(0,12 h) increased with increasing dose, with apparent dose-proportionality between the 20 and 60 mg dose levels. Trough-to-peak ratios at steady state ranged from 2 to 5. Accumulation ratios for the fixed-dose regimens were 1.49 and 1.48 at the 5 and 20 mg dose levels, respectively. Ziprasidone was associated with transient prolactin elevation but levels of prolactin returned to baseline within the dosing interval at steady state. There was a marginal, transient increase in serum prolactin levels which was not dose-related at the 80 and 120 mg day(-1) doses, and which was noted to attenuate with chronic dosing. Ziprasidone was generally well tolerated. The most frequent side-effect was mild or moderate headache. A minority of patients suffered first-dose postural hypotension. Ziprasidone was also associated with a mild sedative effect that became less pronounced as treatment continued. There were no drug-related changes in electrocardiogram or clinical laboratory variables that were of clinical importance.Ziprasidone is characterized by a predictable pharmacokinetic profile resulting in symptoms that reflect its pharmacological action.

Published
2000

119. The effects of ziprasidone on steady-state lithium levels and renal clearance of lithium

Author

Apseloff, G, Mullet, D, Wilner, K D, Anziano, R J, Tensfeldt, T G, Pelletier, S M, and Gerber, N

Subjects
Adult, Male, Thiazoles, Humans, Drug Interactions, Lithium, Middle Aged, Piperazines, Supplement, Antipsychotic Agents
Abstract

To assess the potential of ziprasidone to alter the renal clearance and steady-state serum levels of lithium.Healthy subjects who had stable serum lithium levels during the first 7 days of treatment with lithium 900 mg day(-1), given as two divided daily doses, were randomized to receive concomitant treatment with either ziprasidone, 40 mg day(-1), given as two divided daily doses, on days 9-11 followed by 80 mg day(-1), given as two divided daily doses on days 12-15 (n = 12), or placebo twice daily (n = 13). Ziprasidone or placebo was administered 2 h before each dose of lithium.Ziprasidone administration was associated with a 0.07 mmol l(-1) (13%) mean increase in steady-state serum lithium levels compared with a mean increase of 0.06 mmol l(-1) (10%) with placebo. Mean renal clearance of lithium decreased by 0.09 l h(-1) (5%) in the ziprasidone group and by 0.14 l h(-1) (9%) in the placebo group. None of these differences between the two groups was statistically or clinically significant.Ziprasidone does not alter steady-state serum lithium concentrations or renal clearance of lithium.

Published
2000

120. Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006

Author

Gerber, N U, von Hoff, K, von Bueren, A O, Treulieb, W, Warmuth-Metz, M, Pietsch, T, Soerensen, N, Faldum, A, Emser, A, Schlegel, P G, Deinlein, F, Kortmann, R D, Rutkowski, S, Gerber, N U, von Hoff, K, von Bueren, A O, Treulieb, W, Warmuth-Metz, M, Pietsch, T, Soerensen, N, Faldum, A, Emser, A, Schlegel, P G, Deinlein, F, Kortmann, R D, and Rutkowski, S

Abstract

Ependymoblastoma is a rare malignant brain tumor of early childhood. Data on clinical behavior and optimal treatment strategies are scarce. We report on 11 consecutively treated children with centrally confirmed diagnosis of CNS ependymoblastoma, registered between February 1994 and October 2006 to the prospective GPOH-HIT multicenter brain tumor trials, and treated by multimodal regimens. Median age at diagnosis was 3.5 years (range, 1.8-5.6 years), and the median follow-up of survivors was 5.9 years (range, 2.2-12.7 years). Initial stage was M0 in 9, and M0/1 (no cerebrospinal fluid examination done) in 2 patients. Gross-total tumor resection was achieved in 7 patients, incomplete resection in 4 patients. Further primary therapy included chemotherapy in all patients, craniospinal radiotherapy in 5 patients and high-dose chemotherapy in 2 patients. Tumor response to chemotherapy was observed in 1 of 4 evaluable patients. Tumor progression occurred in 7 patients after a median time of 5.0 months (range, 2.5-19.2 months). Five-year progression-free survival was 36.4% (±14.5%), 5-year overall survival 30.3% (±15.9%). Of 4 survivors, 3 had gross-total tumor resection, and all were treated by either craniospinal radiotherapy and/or high-dose chemotherapy with autologous blood stem cell rescue. Prognosis of children with ependymoblastoma is poor, but sustained remissions have been achieved after multimodal treatment. Considerable diagnostic discrepancies between local and central pathologists underscore the importance of central review. Further studies are needed to improve survival of children with this rare malignant central nervous system tumor.

Published
2011

121. Expression of O(6)-methylguanine-DNA methyltransferase in childhood medulloblastoma

Author

Faoro, D, von Bueren, A O, Shalaby, T, Sciuscio, D, Hürlimann, M L, Arnold, L, Gerber, N U, Haybaeck, J, Mittelbronn, M, Rutkowski, S, Hegi, M, Grotzer, M A, Faoro, D, von Bueren, A O, Shalaby, T, Sciuscio, D, Hürlimann, M L, Arnold, L, Gerber, N U, Haybaeck, J, Mittelbronn, M, Rutkowski, S, Hegi, M, and Grotzer, M A

Abstract

Medulloblastomas (MB) are the most common malignant brain tumors in childhood. Alkylator-based drugs are effective agents in the treatment of patients with MB. In several tumors, including malignant glioma, elevated O(6)-methylguanine-DNA methyltransferase (MGMT) expression levels or lack of MGMT promoter methylation have been found to be associated with resistance to alkylating chemotherapeutic agents such as temozolomide (TMZ). In this study, we examined the MGMT status of MB and central nervous system primitive neuroectodermal tumor (PNET) cells and two large sets of primary MB. In seven MB/PNET cell lines investigated, MGMT promoter methylation was detected only in D425 human MB cells as assayed by the qualitative methylation-specific PCR and the more quantitative pyrosequencing assay. In D425 human MB cells, MGMT mRNA and protein expression was clearly lower when compared with the MGMT expression in the other MB/PNET cell lines. In MB/PNET cells, sensitivity towards TMZ and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) correlated with MGMT methylation and MGMT mRNA expression. Pyrosequencing in 67 primary MB samples revealed a mean percentage of MGMT methylation of 3.7-92% (mean: 13.25%, median: 10.67%). Percentage of MGMT methylation and MGMT mRNA expression as determined by quantitative RT-PCR correlated inversely (n = 46; Pearson correlation r (2) = 0.14, P = 0.01). We then analyzed MGMT mRNA expression in a second set of 47 formalin-fixed paraffin-embedded primary MB samples from clinically well-documented patients treated within the prospective randomized multicenter trial HIT'91. No association was found between MGMT mRNA expression and progression-free or overall survival. Therefore, it is not currently recommended to use MGMT mRNA expression analysis to determine who should receive alkylating agents and who should not.

Published
2011

122. Development of an auditory implant manipulator for minimally invasive surgical insertion of implantable hearing devices

Author

Stieger, C, Caversaccio, M, Arnold, A, Zheng, G, Salzmann, J, Widmer, D, Gerber, N, Thurner, M, Nauer, C, Mussard, Y, Kompis, M, Nolte, L P, Häusler, R, Weber, S, Stieger, C, Caversaccio, M, Arnold, A, Zheng, G, Salzmann, J, Widmer, D, Gerber, N, Thurner, M, Nauer, C, Mussard, Y, Kompis, M, Nolte, L P, Häusler, R, and Weber, S

Abstract

Objective:To present the auditory implant manipulator, a navigation-controlled mechanical and electronic system which enables minimally invasive ('keyhole') transmastoid access to the tympanic cavity.Materials and methods:The auditory implant manipulator is a miniaturised robotic system with five axes of movement and an integrated drill. It can be mounted on the operating table. We evaluated the surgical work field provided by the system, and the work sequence involved, using an anatomical whole head specimen.Results:The work field provided by the auditory implant manipulator is considerably greater than required for conventional mastoidectomy. The work sequence for a keyhole procedure included pre-operative planning, arrangement of equipment, the procedure itself and post-operative analysis.Conclusion:Although system improvements are necessary, our preliminary results indicate that the auditory implant manipulator has the potential to perform keyhole insertion of implantable hearing devices.

Published
2011

123. c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients

Author

von Bueren, A O, Oehler, C, Shalaby, T, von Hoff, K, Pruschy, M, Seifert, Burkhardt, Gerber, N U, Warmuth-Metz, M, Stearns, D, Eberhart, C G, Kortmann, R D, Rutkowski, S, Grotzer, M A, von Bueren, A O, Oehler, C, Shalaby, T, von Hoff, K, Pruschy, M, Seifert, Burkhardt, Gerber, N U, Warmuth-Metz, M, Stearns, D, Eberhart, C G, Kortmann, R D, Rutkowski, S, and Grotzer, M A

Abstract

BACKGROUND: To study whether and how c-MYC expression determines response to radio- and chemotherapy in childhood medulloblastoma (MB). METHODS: We used DAOY and UW228 human MB cells engineered to stably express different levels of c-MYC, and tested whether c-MYC expression has an effect on radio- and chemosensitivity using the colorimetric 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay, clonogenic survival, apoptosis assays, cell cycle analysis, and western blot assessment. In an effort to validate our results, we analyzed c-MYC mRNA expression in formalin-fixed paraffin-embedded tumor samples from well-documented patients with postoperative residual tumor and compared c-MYC mRNA expression with response to radio- and chemotherapy as examined by neuroradiological imaging. RESULTS: In DAOY - and to a lesser extent in UW228 - cells expressing high levels of c-MYC, the cytotoxicity of cisplatin, and etoposide was significantly higher when compared with DAOY/UW228 cells expressing low levels of c-MYC. Irradiation- and chemotherapy-induced apoptotic cell death was enhanced in DAOY cells expressing high levels of c-MYC. The response of 62 of 66 residual tumors was evaluable and response to postoperative radio- (14 responders (CR, PR) vs. 5 non-responders (SD, PD)) or chemotherapy (23 CR/PR vs. 20 SD/PD) was assessed. c-MYC mRNA expression was similar in primary MB samples of responders and non-responders (Mann-Whitney U test, p = 0.50, ratio 0.49, 95% CI 0.008-30.0 and p = 0.67, ratio 1.8, 95% CI 0.14-23.5, respectively). CONCLUSIONS: c-MYC sensitizes MB cells to some anti-cancer treatments in vitro. As we failed to show evidence for such an effect on postoperative residual tumors when analyzed by imaging, additional investigations in xenografts and larger MB cohorts may help to define the exact function of c-MYC in modulating response to treatment.

Published
2011

125. Nitric oxide synthase structure and electron transfer

Author

Pr, Ortiz Montellano, Nishida C, J. Ignacio Rodriguez-Crespo, and Gerber N

Subjects
Electron Transport, Animals, Humans, Nitric Oxide Synthase
Abstract

The nitric oxide synthases (NOS), although unrelated to the cytochromes P450 in terms of sequence, exhibit spectroscopic and catalytic properties strongly reminiscent of those of the P450 system. One important difference is the requirement of the NOS enzymes for tetrahydrobiopterin. The biopterin cofactor is shown by chemical studies to bind close to pyrrole ring D of the prosthetic heme group, a position confirmed recently for inducible NOS and endothelial NOS by crystal structures. The only plausible role so far for the tetrahydrobiopterin is as a transient electron donor for the activation of molecular oxygen. NADPH-derived electrons are provided to the heme by the NOS flavin domain, but the biopterin may be required to provide an electron at a faster rate than that supported by the flavin groups. Chimeras in which the reductase domains of the isoforms have been exchanged indicate that the overall rate of catalytic turnover is directly governed by the ability of the flavin domain to deliver electrons. Electron transfer from the flavin to the heme domain, and within the flavin and heme domains, is thus a critical determinant of the catalytic turnover of NOS.

Published
1998

134. QUALITY OF LIFE/AFTERCARE

Author

Rednam, S., primary, Scheurer, M., additional, Adesina, A., additional, Lau, C., additional, Okcu, M., additional, Deatrick, J., additional, Ogle, S., additional, Fisher, M., additional, Barakat, L., additional, Hardie, T., additional, Li, Y., additional, Ginsberg, J., additional, Ben-Arush, M., additional, Krivoy, E., additional, Rosenkranz, R., additional, Peretz-Nahum, M., additional, Brown, R. J., additional, Love, J., additional, Warburton, D., additional, McBride, W. H., additional, Bluml, S., additional, Mueller, S., additional, Sear, K., additional, Hills, N., additional, Chettout, N., additional, Afghani, S., additional, Lew, L., additional, Tolentino, E., additional, Haas-Kogan, D., additional, Fullerton, H., additional, Reddick, W., additional, Palmer, S., additional, Glass, J., additional, Ogg, R., additional, Gajjar, A., additional, Omar, A., additional, Perkins, S., additional, Shinohara, E., additional, Spoljaric, D., additional, Isenberg, J., additional, Whittington, M., additional, Hauff, M., additional, King, A., additional, Litzelman, K., additional, Barker, E., additional, Catrine, K., additional, Puccetti, D., additional, Possin, P., additional, Witt, W., additional, Mallucci, C., additional, Kumar, R., additional, Pizer, B., additional, Williams, D., additional, Pettorini, B., additional, Piscione, J., additional, Bouffet, E., additional, Shams, I., additional, Kulkarni, A., additional, Remes, T., additional, Harila-Saari, A., additional, Suo-Palosaari, M., additional, Arikoski, P., additional, Riikonen, P., additional, Sutela, A., additional, Koskenkorva, P., additional, Ojaniemi, M., additional, Rantala, H., additional, Campen, C. J., additional, Ashby, D., additional, Fisher, P. G., additional, Monje, M., additional, Kulkarni, A. V., additional, Nakamura, H., additional, Makino, K., additional, Yano, S., additional, Kuratsu, J.-i., additional, Jadrijevic-Cvrlje, F., additional, Batinica, M., additional, Toledano, H., additional, Hoffman, T., additional, Ezer-Cohen, Y., additional, Michowiz, S., additional, Yaniv, I., additional, Cohen, I. J., additional, Adler, I., additional, Mindel, S., additional, Gopalakrishnamoorthy, M., additional, Saunders, D., additional, Gaze, M., additional, Spoudeas, H., additional, Kieffer, V., additional, Dellatolas, G., additional, Chevignard, M., additional, Puget, S., additional, Dhermain, F., additional, Grill, J., additional, Dufour, C., additional, Muir, R., additional, Hunter, A., additional, Latchman, A., additional, de Camargo, O., additional, Scheinemann, K., additional, Dhir, N., additional, Zaky, W., additional, Zomorodian, T., additional, Wong, K., additional, Dhall, G., additional, Macy, M., additional, Lauro, C., additional, Zeitler, P., additional, Foreman, N., additional, Liu, A., additional, Chocholous, M., additional, Dodier, P., additional, Peyrl, A., additional, Dieckmann, K., additional, Hausler, G., additional, Slavc, I., additional, Avula, S., additional, Garlick, D., additional, Armstrong, G., additional, Kawashima, T., additional, Leisenring, W., additional, Stovall, M., additional, Sklar, C., additional, Robison, L., additional, Samaan, C., additional, Duckworth, J., additional, Greenberg-Kushnir, N., additional, Freedman, S., additional, Eshel, R., additional, Zverling, N., additional, Elhasid, R., additional, Dvir, R., additional, Yalon, M., additional, Constantini, S., additional, Wilne, S., additional, Liu, J.-F., additional, Trusler, J., additional, Lundsell, S., additional, Kennedy, C., additional, Clough, L., additional, Dickson, N., additional, Lakhanpaul, M., additional, Baker, M., additional, Dudley, J., additional, Grundy, R., additional, Walker, D., additional, von Hoff, K., additional, Herzog, N., additional, Ottensmeier, H., additional, Grabow, D., additional, Gerber, N. U., additional, Friedrich, C., additional, von Bueren, A. O., additional, Resch, A., additional, Kortmann, R. D., additional, Kaatsch, P., additional, Doerr, H. G., additional, Rutkowski, S., additional, del Bufalo, F., additional, Mastronuzzi, A., additional, Serra, A., additional, de Sio, L., additional, Locatelli, F., additional, Biassoni, V., additional, Leonardi, M., additional, Ajovalasit, D., additional, Riva, D., additional, Vago, C., additional, Usilla, A., additional, Fidani, P., additional, Schiavello, E., additional, Gariboldi, F., additional, Massimino, M., additional, Lober, R., additional, Perrault, S., additional, Partap, S., additional, Edwards, M., additional, Fisher, P., additional, Yeom, K., additional, Salgado, D., additional, Nunes, S., additional, Vinhais, S., additional, Wells, E. M., additional, Seidel, K., additional, Ullrich, N. J., additional, Diller, L., additional, Krull, K. R., additional, Neglia, J., additional, Robison, L. L., additional, Whelan, K., additional, Russell, C. E., additional, Brownstone, D., additional, Kaise, C., additional, Bull, K., additional, Culliford, D., additional, Calaminus, G., additional, Bertin, D., additional, Vallero, S., additional, Romano, E., additional, Basso, M. E., additional, Biasin, E., additional, Fagioli, F., additional, Ziara, K., additional, L'Hotta, A., additional, Williams, A., additional, Thede, R., additional, Moore, K., additional, James, A., additional, Bjorn, E., additional, Franzen, P., additional, Haag, A., additional, Lax, A.-K., additional, Moreno, I., additional, Obeid, J., additional, Timmons, B. W., additional, Iwata, W., additional, Wagner, S., additional, Lai, J.-S., additional, Waddell, K., additional, VanLeeuwen, S., additional, Newmark, M., additional, Noonan, J., additional, O'Connell, K., additional, Urban, M., additional, Yount, S., additional, Goldman, S., additional, Igoe, D., additional, Cunningham, T., additional, Orfus, M., additional, Mabbott, D., additional, Liptak, C., additional, Manley, P., additional, Recklitis, C., additional, Zhang, P., additional, Shaikh, F., additional, Narang, I., additional, Matsumoto, K., additional, Yamasaki, K., additional, Okada, K., additional, Fujisaki, H., additional, Osugi, Y., additional, Hara, J., additional, Phipps, K., additional, Gumley, D., additional, Jacques, T., additional, Hargrave, D., additional, Michalski, A., additional, Chordas, C., additional, Chi, S., additional, Robison, N., additional, Bandopadhayay, P., additional, Marcus, K., additional, Zimmerman, M. A., additional, Goumnerova, L., additional, Kieran, M., additional, Brand, S., additional, Brinkman, T., additional, Delaney, B., additional, Diver, T., additional, Rey, C., additional, Madden, J. R., additional, Hemenway, M. S., additional, Dorneman, L., additional, Stiller, D., additional, Liu, A. K., additional, Foreman, N. K., additional, Vibhakar, R., additional, Mitchell, M., additional, Hemenway, M., additional, Madden, J., additional, Ryan, M., additional, O'Kane, R., additional, Picton, S., additional, Kenny, T., additional, Stiller, C., additional, Chumas, P., additional, Bendel, A., additional, Patterson, R., additional, Barrera, M., additional, Schulte, F., additional, Bartels, U., additional, Janzen, L., additional, Johnston, D., additional, Cataudella, D., additional, Chung, J., additional, Sung, L., additional, Hancock, K., additional, Hukin, J., additional, Zelcer, S., additional, Brandon, S., additional, Montour-Proulx, I., additional, Strother, D., additional, Cooksey, R., additional, Bowers, D., additional, Gargan, L., additional, Gode, A., additional, Klesse, L., additional, Oden, J., additional, Vega, G., additional, Sala, F., additional, Nuzzi, D., additional, Mulino, M., additional, Masotto, B., additional, Mazza, C., additional, Bricolo, A., additional, Gerosa, M., additional, Tong, M., additional, Laughlin, S., additional, Mackie, S., additional, Taylor, L., additional, Sharpe, G., additional, Al-Salihi, O., additional, and Nicolin, G., additional

Published
2012
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135. RADIOLOGY

Author

Murray, J., primary, Braly, E., additional, Head, H., additional, Donahue, D., additional, Rush, S., additional, Stence, N., additional, Liu, A., additional, Kleinhenz, J., additional, Bison, B., additional, Pietsch, T., additional, von Hoff, K., additional, von Bueren, A., additional, Rutkowski, S., additional, Warmuth-Metz, M., additional, Jaspan, T., additional, Brisse, H., additional, Potepan, P., additional, Berg, F., additional, Gerber, N., additional, Sugiyama, K., additional, Kurisu, K., additional, Kajiwara, Y., additional, Takayasu, T., additional, Saito, T., additional, Hanaya, R., additional, Yamasaki, F., additional, Vicente, J., additional, Fuster-Garcia, E., additional, Tortajada, S., additional, Garcia-Gomez, J. M., additional, Davies, N., additional, Natarajan, K., additional, Wilson, M., additional, Grundy, R. G., additional, Wesseling, P., additional, Monleon, D., additional, Celda, B., additional, Robles, M., additional, Peet, A. C., additional, Perret, C., additional, Boltshauser, E., additional, Scheer, I., additional, Kellenberger, C., additional, Grotzer, M., additional, Steffen-Smith, E., additional, Venzon, D., additional, Bent, R., additional, Baker, E., additional, Shandilya, S., additional, Warren, K., additional, Shih, C.-S., additional, West, J., additional, Ho, C., additional, Porter, D., additional, Wang, Y., additional, Saykin, A., additional, McDonald, B., additional, Arfanakis, K., additional, Vezina, G., additional, Hargrave, D., additional, Poussaint, T. Y., additional, Goldman, S., additional, Packer, R., additional, Wen, P., additional, Pollack, I., additional, Zurakowski, D., additional, Kun, L., additional, Prados, M., additional, Kieran, M., additional, Eckel, L., additional, Keating, G., additional, Giannini, C., additional, Wetjen, N., additional, Patton, A., additional, Sarlls, J., additional, Pierpaoli, C., additional, Walker, L., additional, Perreault, S., additional, Lober, R., additional, Yeom, K., additional, Carret, A.-S., additional, Vogel, H., additional, Partap, S., additional, Fisher, P., additional, Gill, S. K., additional, Davies, N. P., additional, MacPherson, L., additional, Arvanitis, T. N., additional, Gill, S., additional, Arvanitis, T., additional, Peet, A., additional, Hayes, L., additional, Jones, R., additional, Mazewski, C., additional, Aguilera, D., additional, Palasis, S., additional, Bendel, A., additional, Patterson, R., additional, Petronio, J., additional, Meijer, L., additional, Grundy, R. G. G., additional, Walker, D. A., additional, Robison, N., additional, Grant, F., additional, Treves, S. T., additional, Bandopadhayay, P., additional, Manley, P., additional, Chi, S., additional, Zimmerman, M. A., additional, Chordas, C., additional, Goumnerova, L., additional, Smith, E., additional, Scott, M., additional, Ullrich, N. J., additional, Poussaint, T., additional, Yang, J. C., additional, Lightner, D. D., additional, Khakoo, Y., additional, Wolden, S. L., additional, Smee, R., additional, Zhao, C., additional, Spencer-Trotter, B., additional, Hallock, A., additional, Konski, A., additional, Bhambani, K., additional, Mahajan, A., additional, Jones, J., additional, Ketonen, L., additional, Paulino, A., additional, Ater, J., additional, Grosshans, D., additional, Dauser, R., additional, Weinberg, J., additional, Chintagumpala, M., additional, Dvir, R., additional, Elhasid, R., additional, Corn, B., additional, Tempelhoff, H., additional, Matceyevsky, D., additional, Makrin, V., additional, Shtraus, N., additional, Yavetz, D., additional, Constantini, S., additional, Gez, E., additional, Yu, E.-S., additional, Kim, Y.-J., additional, Park, H. J., additional, Kim, H. J., additional, Shin, S. H., additional, Kim, J.-H., additional, Kim, J.-Y., additional, Lee, Y. K., additional, Fiore, M. R., additional, Sanne, C., additional, Mandeville, H. C., additional, Saran, F. H., additional, Greenspoon, J., additional, Duckworth, J., additional, Singh, S., additional, Scheinemann, K., additional, Whitton, A., additional, Gauvain, K., additional, Geller, T., additional, Elbabaa, S., additional, Dombrowski, J., additional, Wong, K., additional, Olch, A., additional, Davidson, T. B., additional, Venkatramani, R., additional, Haley, K., additional, Zaky, W., additional, Dhall, G., additional, Finlay, J., additional, Bishop, M. W., additional, Hummel, T. R., additional, Leach, J., additional, Minturn, J., additional, Breneman, J., additional, Stevenson, C., additional, Wagner, L., additional, Sutton, M., additional, Miles, L., additional, and Fouladi, M., additional

Published
2012
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137. Treatment of young children with localized medulloblastoma by chemotherapy alone: Results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology

Author

von Bueren, A. O., primary, von Hoff, K., additional, Pietsch, T., additional, Gerber, N. U., additional, Warmuth-Metz, M., additional, Deinlein, F., additional, Zwiener, I., additional, Faldum, A., additional, Fleischhack, G., additional, Benesch, M., additional, Krauss, J., additional, Kuehl, J., additional, Kortmann, R. D., additional, and Rutkowski, S., additional

Published
2011
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139. Development of an auditory implant manipulator for minimally invasive surgical insertion of implantable hearing devices

Author

Stieger, C, primary, Caversaccio, M, additional, Arnold, A, additional, Zheng, G, additional, Salzmann, J, additional, Widmer, D, additional, Gerber, N, additional, Thurner, M, additional, Nauer, C, additional, Mussard, Y, additional, Kompis, M, additional, Nolte, L P, additional, Häusler, R, additional, and Weber, S, additional

Published
2010
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