101. Phorbol ester receptors: autoradiographic identification in the developing rat.
- Author
-
Murphy KM, Gould RJ, Oster-Granite ML, Gearhart JD, and Snyder SH
- Subjects
- Animals, Autoradiography, Brain embryology, Brain Chemistry, Carrier Proteins, Cell Communication, Cell Division, Central Nervous System analysis, Eye embryology, Intestines embryology, Lens, Crystalline embryology, Phorbol 12,13-Dibutyrate, Rats, Rats, Inbred Strains, Caenorhabditis elegans Proteins, Central Nervous System embryology, Fetus analysis, Phorbol Esters metabolism, Phorbols metabolism, Protein Kinase C, Receptors, Cell Surface analysis, Receptors, Drug
- Abstract
Autoradiography with 3H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18-day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors in the ventral marginal zone of the fetal neural tube, the lens of the eye, and other sites suggests a role for phorbol ester receptors in cellular process extension and cell-cell interaction.
- Published
- 1983
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