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821 results on '"Gasparini, S"'

101. Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: Comparison of adalimumab, etanercept and infliximab in the GISEA registry

Author

Atzeni, F, Sarzi Puttini, P, Botsios, C, Carletto, A, Cipriani, P, Favalli, Eg, Frati, E, Foschi, V, Gasparini, S, Giardina, A, Gremese, E, Iannone, F, Sebastiani, M, Ziglioli, T, Biasi, D, Ferri, C, Galeazzi, M, Gerli, Roberto, Giacomelli, R, Gorla, R, Govoni, M, Lapadula, G, Marchesoni, A, Salaffi, F, Punzi, L, Triolo, G, Ferraccioli, G, on behalf of GISEA, Atzeni F, Sarzi-Puttini P, Botsios C, Carletto A, Cipriani P, Favalli EG, Frati E, Foschi V, Gasparini S, Giardina A, Gremese E, Iannone F, Sebastiani M, Ziglioli T, Biasi D, Ferri C, Galeazzi M, Gerli R, Giacomelli R, Gorla R, Govoni M, Lapadula G, Marchesoni A, Salaffi F, Punzi L, Triolo G, and Ferraccioli G

Subjects
Male, rheumatoid arthritis, Arthritis, Receptors, Tumor Necrosis Factor, Etanercept, Arthritis, Rheumatoid, Adalimumab, Adult, Aged, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Female, Humans, Immunoglobulin G, Incidence, Infection, Infliximab, Middle Aged, Registries, Tumor Necrosis Factors, Rheumatoid, adalimumab, Monoclonal, Receptors, Immunology and Allergy, infections, Humanized, Anti-TNF agents, GISEA register, Infections, Predictive factors, Incidence (epidemiology), Rheumatoid arthritis, Cohort, medicine.drug, anti-TNF, serious infections, medicine.medical_specialty, anti-TNF therapy, etanercept, infliximab, Immunology, Infections, rheumatoid arthritis, anti-TNF therapy, Antibodies, Internal medicine, medicine, business.industry, medicine.disease, Concomitant, Tumor Necrosis Factor Inhibitors, business, Tumor Necrosis Factor
Abstract

Objective: To evaluate the risk of serious infections (SIs) in RA patients receiving anti-TNF therapy on the basis of the data included in the GISEA register. METHODS: The study involved 2769 adult patients with long-standing RA (mean age 53.2±13.4years; mean disease duration 9.0±8.3years) enrolled in the GISEA register, who had been treated for at least 6months with TNF inhibitors or had discontinued therapy due to SI: 837 (30%) treated with infliximab (IFN), 802 (29%) with adalimumab (ADA), and 1130 (41%) with etanercept (ETN). RESULTS: 176 patients had experienced at least one of the 226 Sis during the 9years of treatment with an anti-TNF agent, an overall incidence of 31.8/1000 patient-years (95% CI 25.2-38.3): 23.7/1000 patient-years (95% CI 13.1-34.2) on ADA; 12.8/1000 patient-years (95% CI 6.3-19.4) on ETN and 65.1/1000 patient-years (95% CI 48.4-81.8) on IFN. The risk was higher in the first than in the second year of treatment, but this difference was not statistically significant (p=0.08) (38.9% of the SIs were recorded in the first 12months of treatment). The risk of SI was significantly different among the three treatment groups (p

Published
2012

102. Dermoscopy of scalp tumours: a multi-centre study conducted by the international dermoscopy society

Author

Stanganelli, I, Argenziano, G, Sera, F, Blum, A, Ozdemir, F, Karaarslan, I K, Piccolo, D, Peris, K, Kirchesch, H, Bono, R, Pizzichetta, M A, Gasparini, S, Braun, R P, Correira, O, Thomas, L, Zaballos, P, Puig, S, Malvehy, J, Scalvenzi, M, Rabinovitz, H, Bergamo, A, Pellacani, G, Longo, C, Pavlovic, M, Rosendahl, C, Hofmann-Wellenhof, R, Cabo, H, Marghoob, A A, Langford, D, Astorino, S, Manganoni, A M, Gourhant, J Y, Keir, J, Grichnik, J M, Fumo, G, Dong, H, Sortino Rachou, A M, Ferrara, G, Zalaudek, I, Stanganelli, I, Argenziano, G, Sera, F, Blum, A, Ozdemir, F, Karaarslan, Ik, Piccolo, D, Peris, K, Kirchesch, H, Bono, R, Pizzichetta, Ma, Gasparini, S, Braun, Rp, Correira, O, Thomas, L, Zaballos, P, Puig, S, Malvehy, J, Scalvenzi, Massimiliano, Rabinovitz, H, Bergamo, A, Pellacani, G, Longo, C, Pavlovic, M, Rosendahl, C, Hofmann Wellenhof, R, Cabo, H, Marghoob, Aa, Langford, D, Astorino, S, Manganoni, Am, Gourhant, Jy, Keir, J, Grichnik, Jm, Fumo, G, Dong, H, Sortino Rachou, Am, Ferrara, G, Zalaudek, I., Correia, O, Scalvenzi, M, Hofmann-Wellenhof, R, Zalaudek, I, Argenziano, Giuseppe, Gourhant, J. Y., and University of Zurich

Subjects
Adult, Male, Scalp, Adolescent, 10177 Dermatology Clinic, 610 Medicine & health, Dermoscopy, 2725 Infectious Diseases, Middle Aged, 2708 Dermatology, Young Adult, Infectious Diseases, Aged, Child, Child, Preschool, Female, Humans, Retrospective Studies, Retrospective Studie, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Preschool, Human
Abstract

Little is known about the dermoscopic features of scalp tumours. Objective To determine the dermoscopic features of scalp tumours. METHODS: Retrospective analysis of dermoscopic images of histopathologically diagnosed scalp tumours from International Dermoscopy Society members. RESULTS: A total of 323 tumours of the scalp from 315 patients (mean age: 52 years; range 3-88 years) were analysed. Scalp nevi were significantly associated with young age (65 years and sun damage. Atypical network and regression were predictive for thin (≤1 mm) melanomas, whereas advanced melanomas (tumour thickness > 1 mm) revealed blue white veil, unspecific patterns and irregular black blotches or dots. CONCLUSIONS: The data collected provide a new knowledge regarding the clinical and dermoscopy features of pigmented scalp tumours

Published
2012

103. Magnetic resonance imaging in a lamb with compression of the thoracic spinal cord by an abscess

Author

Braun, Ueli; https://orcid.org/0000-0002-2573-687X, Suárez, J, Gasparini, S, Warislohner, Sonja, Dennler, Matthias; https://orcid.org/0000-0002-8134-9495, Braun, Ueli; https://orcid.org/0000-0002-2573-687X, Suárez, J, Gasparini, S, Warislohner, Sonja, and Dennler, Matthias; https://orcid.org/0000-0002-8134-9495

Abstract

This report describes a two-month-old Ouessant ram lamb with hind limb ataxia, knuckling and falling attributable to an abscess in the thoracic vertebral region. A swelling palpated adjacent to the spinous processes of the 9th to 12th thoracic vertebrae was identified via ultrasonography as an abscess located on the transverse processes of these vertebrae. Magnetic resonance imaging of the lamb postmortem revealed that the abscess had invaded the vertebral canal through a channel at the level of the 9th thoracic vertebra causing extradural spinal cord compression. Postmortem examination confirmed these findings, and histological examination showed acute spinal cord degeneration.

Published
2016

104. The 2003 heat wave and marine plankton communities

Author

Piontkovski, S, Fonda, Serena, Olita, A, de Olazabal, A, Stemmann, L, Rubio, Cg, Gasparini, S, Mazzocchi, Mg, Siokou Frangou, I, Zervoudaki, S, Gubanova, A, Altukhov, D., Astthor Gislason and Gabriel Gorsky, Piontkovski, S, Fonda, Serena, Olita, A, de Olazabal, A, Stemmann, L, Rubio, Cg, Gasparini, S, Mazzocchi, Mg, Siokou Frangou, I, Zervoudaki, S, Gubanova, A, and Altukhov, D.

Subjects
zooplankton heat-wave
Published
2010

105. Comparison of the Recent-Onset ArthritisDisability questionnaire with the Health Assessment Questionnaire disability index in patients with rheumatoid arthritis

Author

Salaffi F, Ciapetti A, Gasparini S, Migliore A, Scarpellini M, Corsaro SM, Laganà B, Mozzani F, Varcasia G, Pusceddu M, Castriotta M, Serale F, Maier A, Foti R, SCARPA, RAFFAELE, Bombardieri S., Salaffi, F, Ciapetti, A, Gasparini, S, Migliore, A, Scarpellini, M, Corsaro, Sm, Laganà, B, Mozzani, F, Varcasia, G, Pusceddu, M, Castriotta, M, Serale, F, Maier, A, Foti, R, Scarpa, Raffaele, and Bombardieri, S.

Subjects
rheumatoid arthritis, Recent-Onset Arthriti, Health Assessment Questionnaire disability index, Disability questionnaire
Published
2010

106. Psychometric properties of an index of three patient reportedoutcome (PRO) measures, termed the CLinical ARthritis Activity (PRO-CLARA) inpatients with rheumatoid arthritis. The NEW INDICES study

Author

Salaffi F, Migliore A, Scarpellini M, Corsaro SM, Laganà B, Mozzani F, Varcasia G, Pusceddu M, Pomponio G, Romeo N, Maier A, Foti R, Gasparini S, Bombardieri S., SCARPA, RAFFAELE, Salaffi, F, Migliore, A, Scarpellini, M, Corsaro, Sm, Laganà, B, Mozzani, F, Varcasia, G, Pusceddu, M, Pomponio, G, Romeo, N, Maier, A, Foti, R, Scarpa, Raffaele, Gasparini, S, and Bombardieri, S.

Subjects
Psychometric properties, rheumatoid arthriti, CLinical ARthritis Activity
Published
2010

107. Drug outcome survey to evaluate anti-TNF treatment in rheumatoid arthritis: an Italian observational study (the DOSE study)

Author

Anecchino, C, Fanizza, C, Marino, V, Romero, M, DOSE Study Group, Costatini, A, Franzin, Mg, Gallo, G, Lattarulo, M, Marchesoni, A, Mazzone, A., Scarpato, S, Valesini, Guido, Celeste, Mg, Di Muzio, G, Gentile R, Perricone R, Garibaldi, Ao, Battaglia, E, Bonaccorsi, Lm, Rapisarda, A, Juric, P, Malavolta, N, Mulè, R, Puggioli, C, Arduini, E, Ceccarelli, Fulvia, Valesini, G, Bianchi, S, Padovan M, Trotta F, Bazzichi, L, Consensi, A, Dal Canto, L, Doveri, M, Polvani, M., Bello, S, Bonali, C, Intini, S, Faggioli, A, Cesta V, Costantini A, Cavaliere, A, Laurenti, R, Dell'Orso, B, De Simone, M, Meschini, C, Bellantoni, A, Massari, V, Rotunno, L., Ciapetti, A, Gasparini, S, Grassi, W, Lupi, E, Verri, F, Del Pizzo, V, Donadio, D, Ferrucci, Mg, Goglia, C, Racca, A, Stisi, S, Maesano, C., Ferraccioli, G., Jacoboni, Er, Privitera, R, Proli, Em, Galeazzi, M, Menza, L, Misiani, F, Tarantino, A, Capobianco, L, D'Onofrio, F, Stea, S, Silvi, E, and Vitocolonna, E.

Subjects
Adult, Male, Drug Resistance, Severity of Illness Index, Etanercept, Arthritis, Rheumatoid, Disability Evaluation, Sex Factors, Drug Therapy, Rheumatoid, Humans, Prospective Studies, Age Factors, Aged, Drug Monitoring, Drug Therapy, Combination, Female, Italy, Middle Aged, Treatment Outcome, Tumor Necrosis Factor-alpha, Adalimumab, Antirheumatic Agents, Infliximab, Arthritis, Combination
Abstract

The aim of this paper is to analyse the use of anti-TNF drugs in current Italian practice, evaluate clinical responses to treatment, and identify possible predictors of negative response in patients with rheumatoid arthritis (RA).DOSE is a non-interventional, prospective study of patients with active RA treated for the first time with anti-TNF agents in 21 Italian hospitals. Demographic and clinical characteristics of patients, treatments and outcome measures were assessed. Outcome measures used were EULAR response, DAS28 remission and HAQ remission at 12 months. A stepwise logistic regression model was used to study the predictors of non-response.Of 299 RA patients (mean 53.8 ± 12.8 years, 76.1% female), DAS28 was5.1 in 60.5% of patients and HAQ was1 in 65.9%. Etanercept was the most prescribed anti-TNF. DMARDs were used in 77.6% of patients (methotrexate in 59.2%). Significant improvements in clinical and laboratory parameters were observed at 12 months. The proportion of patients classed as non-responders remained high, and varied according to assessment criteria. The main predictors independently and significantly associated with a high risk of non-response were: age and female gender for all outcome criteria; high DAS28 value for disease remission; and HAQ1 for disability remission.In Italian anti-TNF treatment for RA, age, gender, and high values of both disease activity and disability were predictors of non-response to first-line therapy with anti-TNF drugs. Future studies should consider optimal second-line therapies for RA patients who do not achieve remission to their first anti-TNF treatment.

Published
2014

108. Ecological geography of the Mediterranean Sea

Author

Reygondeau, Gabriel, Irisson, Jean-Olivier, Albouy, Camille, Ayata, Sakina-Dorothée, Benedetti, Fabio, Guieu, Cécile, Gasparini, S., Koubbi, Philippe, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ecologie des systèmes marins côtiers (Ecosym), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), UMR 212 EME 'écosystèmes marins exploités' (EME), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience

Published
2014

110. Mediterranean biodiversity (from phytoplankton to top predators) and present threats

Author

Reygondeau, Gabriel, Albouy, Camille, Hattab, Tarek, Benedetti, Fabio, Irisson, Jean-Olivier, Ayata, Sakina-Dorothée, Gasparini, S., Mckenzie, C., Koubbi, P., Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Ecologie des systèmes marins côtiers (Ecosym), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), UMR 212 EME 'écosystèmes marins exploités' (EME), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM), Ecosystèmes et Ressources Aquatiques (UR03AGRO1), Institut National Agronomique de Tunisie, Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and University of Otago [Dunedin, Nouvelle-Zélande]

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience

Published
2014

111. Present status of Mediterranean marine biodiversity and potential anthropogenic threat

Author

Reygondeau, Gabriel, Albouy, Camille, Hattab, Tarek, Benedetti, Fabio, Irisson, Jean-Olivier, Ayata, Sakina, Gasparini, S., Mckenzie, C., Guieu, Cécile, Koubbi, Philippe, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Ecologie des systèmes marins côtiers (Ecosym), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), UMR 212 EME 'écosystèmes marins exploités' (EME), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM), Ecosystèmes et Ressources Aquatiques (UR03AGRO1), Institut National Agronomique de Tunisie, University of Otago [Dunedin, Nouvelle-Zélande], Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience

Published
2014

112. Clinical highlights from the ERS congress in Barcelona

Author

Spruit, M. A., Marvisi, M., Coolen, J., Poletti, V., Gasparini, S., Ställberg, B., Herth, F. J. F., and Clini, Enrico

Subjects
primary care, interventional pneumology, COPD, rehabilitation, interstitial lung diseases
Published
2014

117. Guidelines in dermoscopy

Author

CHIMENTI S, ARGEBZIANO G, DI STEFANI A, ANDREASSI L, PACRLI P, DE GIORGI V, FERRARA G, FERRARI A, GASPARINI S, GIOVENE L, LOMUTO M, MAZZOCCHETTI G, PELLACANO G, PERIS K, PICCOLO D, PIZZICHETTA M. A, RUBEGNI P, SEIDENARI S. SERRESI S, STANGANELLI I, GIABBOTTI B., SCALVENZI, MASSIMILIANO, Chimenti, S, Argebziano, G, DI STEFANI, A, Andreassi, L, Pacrli, P, DE GIORGI, V, Ferrara, G, Ferrari, A, Gasparini, S, Giovene, L, Lomuto, M, Mazzocchetti, G, Pellacano, G, Peris, K, Piccolo, D, Pizzichetta, M. A., Rubegni, P, Scalvenzi, Massimiliano, SEIDENARI S., SERRESI S, Stanganelli, I, and Giabbotti, B.

Published
2005

118. Guidelines in dermoscopy

Author

Chimenti, S, Argenziano, G, Di Stefani, A, Andreassi, L, Carli, P, De Giorgi, V, Ferrara, G, Ferrari, A, Gasparini, S, Giovene, Gl, Lo muto, M, Mazzocchetti, G, Pellacani, G, Pellicano, R, Peris, K, Piccolo, D, Pizzichetta, Ma, Rubegni, P, Scalvenzi, M, Seidenari, S, Serresi, S, Stanganelli, I, Giannotti, B, Chimenti, S, Argenziano, G, Di Stefani, A, Andreassi, L, Carli, P, De Giorgi, V, Ferrara, G, Ferrari, A, Gasparini, S, Giovene, Gl, Lo muto, M, Mazzocchetti, G, Pellacani, G, Pellicano, R, Peris, K, Piccolo, D, Pizzichetta, Ma, Rubegni, P, Scalvenzi, M, Seidenari, S, Serresi, S, Stanganelli, I, and Giannotti, B

Subjects
practice guidelines, practice guideline, melanoma, follow-up
Abstract

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Published
2005

119. A MSFD complementary approach for the assessment of pressures, knowledge and data gaps in Southern European Seas: The PERSEUS experience

Author

Crise, A., Kaberi, H., Ruiz, J., Zatsepin, A., Arashkevich, E., Giani, M., Karageorgis, Aristomenis, Prieto, L., Pantazi, M., Gonzalez-fernandez, D., D'Alcala, M. Ribera, Tornero, V., Vassilopoulou, V., Durrieu De Madron, Xavier, Guieu, C., Puig, P., Zenetos, A., Andral, Bruno, Angel, D., Altukhov, D., Ayata, S. D., Aktan, Y., Balcioglu, E., Benedetti, F., Bouchoucha, Marc, Buia, M. -c., Cadiou, Jean-francois, Canals, M., Chakroun, M., Christou, E., Christidis, M. G., Civitarese, Giuseppe, Coatu, V., Corsini-foka, M., Cozzi, S., Deidun, A., Dell'Aquila, A., Dogrammatzi, A., Dumitrache, C., Edelist, D., Ettahiri, Omar, Fonda-umani, S., Gana, S., Galgani, Francois, Gasparini, S., Giannakourou, A., Gomoiu, M. -t., Gubanova, A., Gucu, Ali-cemal, Gurses, Ozgur, Hanke, G., Hatzianestis, I., Herutx, B., Hone, R., Huertas, E., Irisson, J. -o., Isinibilir, M., Jimenez, J. A., Kalogirou, S., Kapiris, K., Karamfilov, Ventzi, Kavadas, S., Keskin, G., Kideys, Ahmet, Kocak, M., Kondylatos, G., Kontogiannis, C., Kosyan, R., Koubbi, Philippe, Kuspilic, G., La Ferla, R., Langone, L., Laroche, Sophie, Lazar, Luminita, Lefkaditou, E., Lemeshko, I. E., Machias, A., Malej, A., Mazzocchi, M. -g., Medinets, Volodymyr, Mihalopoulos, N., Miserocchi, S., Moncheva, Snejana, Mukhanov, V., Oaie, Gheorghe, Oros, A., Ozturk, A. A., Ozturk, B., Panayotova, M., Prospathopoulos, A., Radu, G., Raykov, V., Regiero, P., Reygondeau, G., Rougeron, Natacha, Salihoglu, B., Sanchez-vidal, A., Sannino, G., Santinelli, C., Secrieru, D., Shapiro, G., Simboura, N., Shiganova, Tamara, Sprovieri, M., Stefanova, Kremena, Streftaris, N., Tirelli, V., Tom, Moshe, Topaloglu, B., Topcu, N. E., Tsagarakis, K., Tsangaris, C., Tserpes, G., Tugrul, S., Uysal, Z., Vasile, Daniela, Violaki, K., Xu, J., Yuksek, Ahsen, Papathanassiouh, E., Crise, A., Kaberi, H., Ruiz, J., Zatsepin, A., Arashkevich, E., Giani, M., Karageorgis, Aristomenis, Prieto, L., Pantazi, M., Gonzalez-fernandez, D., D'Alcala, M. Ribera, Tornero, V., Vassilopoulou, V., Durrieu De Madron, Xavier, Guieu, C., Puig, P., Zenetos, A., Andral, Bruno, Angel, D., Altukhov, D., Ayata, S. D., Aktan, Y., Balcioglu, E., Benedetti, F., Bouchoucha, Marc, Buia, M. -c., Cadiou, Jean-francois, Canals, M., Chakroun, M., Christou, E., Christidis, M. G., Civitarese, Giuseppe, Coatu, V., Corsini-foka, M., Cozzi, S., Deidun, A., Dell'Aquila, A., Dogrammatzi, A., Dumitrache, C., Edelist, D., Ettahiri, Omar, Fonda-umani, S., Gana, S., Galgani, Francois, Gasparini, S., Giannakourou, A., Gomoiu, M. -t., Gubanova, A., Gucu, Ali-cemal, Gurses, Ozgur, Hanke, G., Hatzianestis, I., Herutx, B., Hone, R., Huertas, E., Irisson, J. -o., Isinibilir, M., Jimenez, J. A., Kalogirou, S., Kapiris, K., Karamfilov, Ventzi, Kavadas, S., Keskin, G., Kideys, Ahmet, Kocak, M., Kondylatos, G., Kontogiannis, C., Kosyan, R., Koubbi, Philippe, Kuspilic, G., La Ferla, R., Langone, L., Laroche, Sophie, Lazar, Luminita, Lefkaditou, E., Lemeshko, I. E., Machias, A., Malej, A., Mazzocchi, M. -g., Medinets, Volodymyr, Mihalopoulos, N., Miserocchi, S., Moncheva, Snejana, Mukhanov, V., Oaie, Gheorghe, Oros, A., Ozturk, A. A., Ozturk, B., Panayotova, M., Prospathopoulos, A., Radu, G., Raykov, V., Regiero, P., Reygondeau, G., Rougeron, Natacha, Salihoglu, B., Sanchez-vidal, A., Sannino, G., Santinelli, C., Secrieru, D., Shapiro, G., Simboura, N., Shiganova, Tamara, Sprovieri, M., Stefanova, Kremena, Streftaris, N., Tirelli, V., Tom, Moshe, Topaloglu, B., Topcu, N. E., Tsagarakis, K., Tsangaris, C., Tserpes, G., Tugrul, S., Uysal, Z., Vasile, Daniela, Violaki, K., Xu, J., Yuksek, Ahsen, and Papathanassiouh, E.

Abstract

PERSEUS project aims to identify the most relevant pressures exerted on the ecosystems of the Southern European Seas (SES), highlighting knowledge and data gaps that endanger the achievement of SES Good Environmental Status (GES) as mandated by the Marine Strategy Framework Directive (MSFD). A complementary approach has been adopted, by a meta-analysis of existing literature on pressure/impact/knowledge gaps summarized in tables related to the MSFD descriptors, discriminating open waters from coastal areas. A comparative assessment of the Initial Assessments (IAs) for five SES countries has been also independently performed. The comparison between meta-analysis results and IAs shows similarities for coastal areas only. Major knowledge gaps have been detected for the biodiversity, marine food web, marine litter and underwater noise descriptors. The meta-analysis also allowed the identification of additional research themes targeting research topics that are requested to the achievement of GES.

Published
2015
Full Text
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122. An educational campaign toward epilepsy among Italian primary school teachers: 1. Survey on knowledge and attitudes

Author

Mecarelli, Oriano, Messina, P., Capovilla, G., Michelucci, R., Romeo, A., Beghi, E., De Simone, R., Lucibello, S., Ferrari, A., Vecchi, M., de Palma, L., Monti, F., Ferlazzo, E., Gasparini, S., Passarelli, D., Lodi, M., Cesaroni, E., Stranci, G., Elia, M., Severi, S., Pizzanelli, C., Ausserer, H., Dordi, B., Montalenti, E., Pieri, I., Galeone, D., Germano, M., Cantisani, T., Casellato, S., and Pruna, D.

Subjects
Adult, Male, knowledge, Health Knowledge, Attitudes, Practice, Epilepsy, Schools, Faculty, Health Surveys, Interviews as Topic, Italy, Seizures, Surveys and Questionnaires, school teachers, Humans, Female, Child, Students, epilepsy
Abstract

A questionnaire survey was undertaken to assess the impact of a nationwide educational campaign about epilepsy on the knowledge and attitudes toward the disease among Italian primary school teachers. Five hundred and eighty-two teachers participated. All interviewees were aware of the existence of epilepsy, and most of them had direct experience with the disease. Answers about frequency, causes, outcome, and response to treatments were variable and not correlated with age, residency, and years of experience. Teachers had positive attitudes toward epilepsy, except for the idea that driving and sports can be safe for people with epilepsy. Epilepsy and its treatment were considered a source of learning disability and social disadvantages. Several teachers declared themselves being unable to help a child having seizures. Calling an ambulance was a frequent action. Knowledge and attitudes toward epilepsy are improved compared with those reported in our previous studies. Although this may be a positive reflection of the increasing knowledge and the greater availability of information on epilepsy, there are still areas of uncertainty and incorrect behaviors.

Published
2013

123. Toward a dynamic biogeochemical division of the Mediterranean Sea in a context of global climate change

Author

Reygondeau, Gabriel, Irisson, Jean-Olivier, Guieu, Cécile, Gasparini, S., Ayata, Sakina-Dorothée, Koubbi, Philippe, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience

Published
2013

125. Ecoregionalisation of the Mediterranean Sea

Author

Reygondeau, Gabriel, Irisson, Jean-Olivier, Albouy, Camille, Ayata, Sakina-Dorothée, Benedetti, Fabio, Guieu, Cécile, Gasparini, S., Koubbi, Philippe, UMR 212 EME 'écosystèmes marins exploités' (EME), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM), Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Departement de Biologie, Chimie et Géographie, and Université du Québec à Rimouski (UQAR)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Published
2013

126. Novel modalities and agents in bronchoscopic lung volume reduction

Author

Stratakos, G. Emmanouil, P. Gasparini, S.

Subjects
respiratory system, respiratory tract diseases
Abstract

The NETT study has shown the effectiveness of lung volume reduction surgery (LVRS) in improving functional parameters and exercise tolerance in selected patients with severe pulmonary emphysema of upper lobe predominance. A number of bronchoscopic techniques have since been developed under the term "bronchoscopic lung volume reduction" (BLVR), aiming to lower the complications and the cost while facilitating the procedure of lung volume approach in patients with emphysema. These include airway bypass by creation of airway/parenchyma communications, one-way endobronchial valves occluding the airways of the targeted lobes, endobronchial coils which mechanically contract the parenchyma, hot vapour ablation thermally destroying the targeted sites and sealant which fill the alveoli with polymer material. These methods are generally simple and safe, with a favourable complications profile, requiring less infrastructure and interventional experience than the open surgical approach. Bronchial valves have produced promising results in a very narrow phenotype of emphysema patients and have the major advantage of being reversible in their action. Parenchymal interventions at the cost of producing permanent effects and a transient inflammatory syndrome, may be effective in larger group of patients regardless of the fissure integrity and the presence of collateral ventilation. New, more extensive multicentre studies are underway which aim at better selection and stratification of patients in order to further evaluate the safety and effectiveness of these techniques, before wider use of this revolutionary approach for severe lung emphysema can be advocated. © 2013 Bentham Science Publishers.

Published
2013

127. Classical test theory and Rasch analysis validation of the Recent-Onset Arthritis Disability questionnaire in rheumatoid arthritis patients

Author

Salaffi, F, Franchignoni, F, Giordano, A, Ciapetti, A, Gasparini, S, Ottonello, M, 'NEW INDICES' Study Group, Lagana', Bruno, Fausto, Salaffi, Franco, Franchignoni, Andrea, Giordano, Alessandro, Ciapetti, Stefania, Gasparini, Marcella, Ottonello, and Scarpa, Raffaele

Subjects
Adult, Male, Questionnaires, medicine.medical_specialty, Activities of daily living, Settore MED/16 - REUMATOLOGIA, Psychometrics, Motor Activity, Severity of Illness Index, Classical test theory, Arthritis, Rheumatoid, Disability Evaluation, Rheumatology, Surveys and Questionnaires, Rheumatoid, Activities of Daily Living, Outpatients, Medicine, Humans, Aged, Rasch model, business.industry, Arthritis, Reproducibility of Results, General Medicine, Middle Aged, Explained variation, Confirmatory factor analysis, Physical therapy, Patient-reported outcome, Observational study, Female, business
Abstract

Disability has been identified as a core outcome measure in rheumatoid arthritis (RA). The aim of this study was to perform a comprehensive psychometric analysis of the Recent-Onset Arthritis Disability (ROAD) questionnaire in patients with RA. The questionnaire was completed by 583 patients with RA: 196 subjects participating in the NEW INDICES study and 387 subjects who were taking part in a long-term observational study. At confirmatory factor analysis for categorical data, data fit for a three-factor model was adequate to good (non-normed fit index = 0.98, comparative fit index = 0.99, root mean square error of approximation = 0.079, standardized root mean square residual = 0.047), with standardized item-to-factor loadings ranging from 0.60 to 0.90 and a cumulative explained variance of 83 %. The bifactor model of ROAD presented a clean independent cluster structure. The loadings in the unidimensional model were very similar to those on the general factor in the bifactor model. Rasch analysis showed a correct functioning of rating categories, a good fit of the data to the model for all three subscales, and satisfactory separation indexes and respective reliability (for both persons and items). This study, using both classical test theory and Rasch analysis methods, provides psychometric evidence of the reliability and internal and structural validity of ROAD in RA patients. Our results support the use of separate subscores for upper limb function, lower limb function, and activities of daily living/work, and the appropriateness of reporting an overall score (i.e., the mean of the three subscales).

Published
2013

129. Maspin expression is a favorable prognostic factor in non-small cell lung cancer

Author

Rossana Berardi, Santinelli, A., Onofri, A., Brunelli, A., Pierantoni, C., Pisa, E., Pagliacci, A., Stramazzotti, D., Zuccatosta, L., Mazzanti, P., Sabbatini, A., Gasparini, S., Bearzi, I., Cascinu, S., R., Berardi, A., Santinelli, A., Onofri, A., Brunelli, C., Pierantoni, E., Pisa, A., Pagliacci, D., Stramazzotti, L., Zuccatosta, P., Mazzanti, A., Sabbatini, S., Gasparini, I., Bearzi, and Cascinu, Stefano

Subjects
Adult, Male, Lung Neoplasms, Prognosi, Biopsy, Tumor Marker, Adenocarcinoma, metabolism/mortality/pathology, Adult, Aged, Aged, 80 and over, Biopsy, Carcinoma, Non-Small-Cell Lung, metabolism/mortality/pathology, Carcinoma, Squamous Cell, metabolism/mortality/pathology, Female, Humans, Immunohistochemistry, methods, Lung Neoplasms, metabolism/mortality/pathology, Male, Middle Aged, Prognosis, Retrospective Studies, Serpins, metabolism, Tumor Markers, Biological, metabolism, Retrospective Studie, Carcinoma, Non-Small-Cell Lung, 80 and over, Biomarkers, Tumor, Humans, Serpins, Aged, Retrospective Studies, Serpin, Aged, 80 and over, metabolism/mortality/pathology, Carcinoma, Middle Aged, Prognosis, Immunohistochemistry, Lung Neoplasm, method, Carcinoma, Squamous Cell, Female, Human
Abstract

To evaluate prognostic impact of maspin expression in patients with resected non-small cell lung cancer (NSCLC).From 1996 to 2001, 439 patients underwent radical surgery for NSCLC at the Polytechnic University of the Marche Region. Maspin expression was detected as cytoplasmic and nuclear staining of neoplastic cells. For cytoplasmic staining, cases were classified as negative, low positive, and high positive. In positive cases, intensity of staining was also considered and scored. A similar classification was used for nuclear staining, but intensity was not considered.The analysis showed that smoking history, pathologic stage of disease, N status, histologic grading, sex, and Eastern Cooperative Oncology Group performance status had a prognostic impact on overall survival (OS). Expression of maspin was also found to be an independent prognostic factor. A statistically significant longer OS was seen in patients with higher compared with lower expression of nuclear maspin, and poorer OS was present in patients with a higher intensity of cytoplasmic staining. Nuclear expression of maspin was also found to be an independent prognostic factor at multivariate analysis.Results suggest that overexpression of maspin correlates with favorable prognosis in NSCLC. and may be a useful clinical marker.

Published
2012

131. Development of the benthic toxic dinoflagellate Ostreopsis cf. ovata in the NW Mediterranean sea

Author

Cohu, S., Lemee, R., Mangialajo, L., Aurelie Blanfuné, Gasparini, S., Guidi-Guilvard, L., Marro, S., Thierry THIBAUT, Ecosystèmes Côtiers Marins et Réponses aux Stress (ECOMERS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

International audience; Development of the benthic toxic dinoflagellate Ostreopsis cf. ovata in the NW Mediterranean sea.

Published
2011

132. The effect of Ostreopsis cf. ovata, a toxic benthic dinoflagellate, on phytal meiofauna from the coastal NW Mediterranean

Author

Guidi-Guilvard, L., Gasparini, S., Lemee, R., Aurelie Blanfuné, Cohu, S., Mangialajo, L., Thierry THIBAUT, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes Côtiers Marins et Réponses aux Stress (ECOMERS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

International audience; The effect of Ostreopsis cf. ovata, a toxic benthic dinoflagellate, on phytal meiofauna from the coastal NW Mediterranean.

Published
2011

133. The French research project MediOs 2 (Mediterranée Ostreopsis) and the relations with managers and policy makers

Author

Lemee, R., Mangialajo, L., Amzil, Z., Aurelie Blanfuné, Chomerat, N., Cohu, S., Ganzin, N., Gasparini, S., Grossel, H., Guidi-Guilivard, L., Hoareau, L., Leduff, F., Marro, S., Natalie Simon, Nezan, E., Pedrotti, M. L., Séchet, V., Soliveres, O., Thierry THIBAUT, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes Côtiers Marins et Réponses aux Stress (ECOMERS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
[SDE.ES]Environmental Sciences/Environmental and Society
Abstract

International audience; The French research project MediOs 2 (Mediterranée Ostreopsis) and the relations with managers and policy makers.

Published
2011

134. Impact d'un dinoflagellé benthique toxique Ostreopsis cf. ovata sur l'abondance et la composition de la méiofaune des macroalgues en Méditerranée nord-occidentale

Author

Guidi-Guilvard, L., Gasparini, S., Lemee, R., Aurelie Blanfuné, Cohu, S., Mangialajo, L., Thierry THIBAUT, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes Côtiers Marins et Réponses aux Stress (ECOMERS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

National audience; Impact d'un dinoflagellé benthique toxique Ostreopsis cf. ovata sur l'abondance et la composition de la méiofaune des macroalgues en Méditerranée nord-occidentale.

Published
2011

136. Marine ecosystems'responses to climatic and anthropogenic forcings in the Mediterranean

Author

Durrieu de Madron, X., Guieu, C., Sempéré, R., Conan, P., Cossa, D., D'Ortenzio, F., Estournel, C., Gazeau, F., Rabouille, C., Stemmann, L., Bonnet, Sophie, Diaz, Frédéric, Koubbi, P., Radakovitch, O., Babin, M., Baklouti, M., Bancon-Montigny, C., Belviso, S., Bensoussan, N., Bonsang, B., Bouloubassi, I., Brunet, C., Cadiou, J.F., Carlotti, F., Chami, M., Charmasson, S., Charrière, B., Dachs, J., Doxaran, D., Dutay, J.C., Elbaz Poulichet, F., Eléaume, M., Eyrolles, F., Fernandez, C., Fowler, S., Francour, P., Gaertner, J.C., Galzin, R., Gasparini, S., Ghiglione, J.F., Gonzalez, J.L., Goyet, C., Guidi, L., Guizien, K., Heimbürger, L.E., Jacquet, S.H.M., Jeffrey, W.H., Joux, F., Le Hir, P., Leblanc, K., Lefèvre, D., Lejeusne, C., Lemé, R., Loÿe-Pilot, M.D., Mallet, M., Méjanelle, L., Mélin, F., Mellon, C., Mérigot, B., Merle, P.L., Migon, C., Miller, W.L., Mortier, L., Mostajir, B., Mousseau, L., Moutin, T., Para, J., Pérez, T., Petrenko, A., Poggiale, J.C., Prieur, L., Pujo-Pay, M., Pulido-Villena, Raimbault, P., Rees, A.P., Ridame, C., Rontani, J.F., Ruiz Pino, D., Sicre, M.A., Taillandier, V., Tamburini, C., Tanaka, T., Taupier-Lepage, I., Tedetti, M., Testor, P., Thébault, H., Thouveni, B., Touratier, F., Tronczynski, J., Ulses, C., Van Wambeke, F., Vantrepotte, V., Vaz, S., and Verney, R.

Subjects
CIRCULATION OCEANIQUE, PHYTOPLANCTON, ALTERATION, ZOOPLANCTON, FONCTIONNEMENT DE L'ECOSYSTEME, SEL NUTRITIF, RADIATION SOLAIRE, TEMPERATURE, FACTEUR ANTHROPIQUE, CYCLE BIOGEOCHIMIQUE, ACIDIFICATION, IMPACT SUR L'ENVIRONNEMENT
Published
2011

138. A randomized study of endobronchial valves for advanced emphysema

Author

Sciurba, Fc, Ernst, A, Herth, Fj, Strange, C, Criner, Gj, Marquette, Ch, Kovitz, Kl, Chiacchierini, Rp, Goldin, J, Mclennan, G, Sciurba, F, Landreneau, R, Crespo, M, Lane, L, Slivka, W, Fuhrman, C, Ferson, P, Witt, C, End, A, Schneider, F, Klepetko, W, Stanzel, F, Weber, N, Haeussinger, K, Gasparini, S, De Luca, S, Golden, E, Smith, M, Williams, G, Feller Kopman, D, Garland, R, Ashiku, S, Decamp, M, Ferguson, G, Thompson, Tm, McKenna R., Jr, Geaga, C, Kusuanco, D, Pison, Ch, Wuyam, B, Ferretti, G, Vivodtzev, I, Righini, C, Lebargy, F, Deslee, G, Dury, S, Schmidt, B, Gonzalez Bermejo, J, Trosini Desert, V, Similowski, T, Beigelman, C, Becquemin, Mh, Simoff, M, Almario, R, Mal, H, Marceau, A, Fournier, M, Brugière, O, Dauriat, G, Marquette, C, Leroy, S, Perez, T, Bautin, N, Massard, G, Kessler, R, Charloux, A, Jeung, My, Jory, A, Muir, Jf, Viacroze, C, Benhamou, D, Cuvelier, A, Molano, L, Degano, B, Hermant, C, Pontier, S, Rami, J, Chabbert, V, Vergnon, Jm, Veyret, C, Costes, F, De Matos, L, Febvre, M, Chouaid, C, Lebeau, B, Pinet, C, Dutau, H, Thomas, P, Badier, M, Gaubert, Jy, Xaubet, A, Torres, A, Agustí, C, Barberà, J, Agustí, A, Togores, B, Renom, F, Sauleda, J, Ramos, R, Nathan, S, Ahmad, S, Collazo, L, Battle, E, Hecker, E, Volmerig, J, Jahn, T, Ficker, J, Wagner, M, Fink, T, Egan, J, Coyle, J, Edell, E, Midthun, D, Utz, J, Andrist, B, Meiras, K, Silvestri, G, Williams Cummings, E, Freilich, E, Amin, D, Masson, J, Orlando, D, Morgan, L, Bowler, R, Wheeler, C, Mitchell, K, Maxfield, R, Ginsburg, M, Jellen, P, Brogan, F, Valipour, A, Kohansal, R, Burghuber, C, Elton, D, Sy, A, Mcfarland, E, Haase, N, Stout, M, Tillis, W, Whitten, P, Crabb, J, Hartwig, K, Scott, A, Levine, B, Ross, J, Baratz, D, Fu, L, Cordasco, E, Adamo, J, Botte, J, Voelker, K, Horiuchi, T, Hurwitz, K, Ferreira, G, Morgan, K, Jantz, M, Deem, A, Fox, A, Campbell, S, Vincent, T, Shen, W, Hazelrigg, S, Boley, T, Boomer, Wm, Goulet, J, Mullins, C, Cicena, J, O'Neill, P, Criner, G, Travaline, J, Chatila, W, Jones, G, Herth, F, Eberhardt, R, Leeds, W, Fair, G, Ludlow, L, Nicklin, S, Davis, C, Kovitz, K, Ditta, S, Chan, A, Allen, R, Albertson, T, Morrissey, B, Juarez, M, Germonpre, P, Janssens, A, De Backer, W, Noppen, M, De Mey, J, Meysman, M, Ferguson, J, Ross, A, Sprenger, K, Keating, J, Zgoda, M, Berger, R, Mcclung, J, Cortes, R, Krasna, M, Britt, J, Gamliel, Z, Moskowitz, I, Gay, S, Konkle, J, Goodnight White, S, Soubra, S, Smithwick, P, Velamuri, K, Cooper, C, Badduke, B, Hsiao, E, Wise, R, Celli, B, Ciccone, Annamaria, Keenan, R, Gilman, D, Brown, M, McNitte Gray, M, da Costa, I, Ho, J, Kaplan, R, Ganiats, T, Groessl, E, Harvey, J, Mulligan, B., Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Antoine [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
MESH: Exercise Tolerance, Exacerbation, MESH: Pulmonary Disease, Chronic Obstructive, law.invention, MESH: Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Randomized controlled trial, law, Forced Expiratory Volume, Medicine, 030212 general & internal medicine, Antibiotic prophylaxis, Pneumonectomy, MESH: Aged, COPD, Exercise Tolerance, MESH: Middle Aged, Respiratory disease, Prostheses and Implants, General Medicine, Middle Aged, Bronchodilator Agents, 3. Good health, Pulmonary Emphysema, MESH: Pulmonary Emphysema, Respiratory Physiological Phenomena, Adult, medicine.medical_specialty, Randomization, MESH: Prostheses and Implants, MESH: Forced Expiratory Volume, 03 medical and health sciences, Internal medicine, Bronchoscopy, MESH: Antibiotic Prophylaxis, Humans, MESH: Bronchoscopy, Aged, Proportional Hazards Models, MESH: Humans, business.industry, Proportional hazards model, MESH: Pneumonectomy, Endobronchial valve, MESH: Adult, Antibiotic Prophylaxis, medicine.disease, Surgery, MESH: Respiratory Physiological Phenomena, 030228 respiratory system, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Bronchodilator Agents, business
Abstract

International audience; BACKGROUND: Endobronchial valves that allow air to escape from a pulmonary lobe but not enter it can induce a reduction in lobar volume that may thereby improve lung function and exercise tolerance in patients with pulmonary hyperinflation related to advanced emphysema. METHODS: We compared the safety and efficacy of endobronchial-valve therapy in patients with heterogeneous emphysema versus standard medical care. Efficacy end points were percent changes in the forced expiratory volume in 1 second (FEV1) and the 6-minute walk test on intention-to-treat analysis. We assessed safety on the basis of the rate of a composite of six major complications. RESULTS: Of 321 enrolled patients, 220 were randomly assigned to receive endobronchial valves (EBV group) and 101 to receive standard medical care (control group). At 6 months, there was an increase of 4.3% in the FEV1 in the EBV group (an increase of 1.0 percentage point in the percent of the predicted value), as compared with a decrease of 2.5% in the control group (a decrease of 0.9 percentage point in the percent of the predicted value). Thus, there was a mean between-group difference of 6.8% in the FEV1 (P=0.005). Roughly similar between-group differences were observed for the 6-minute walk test. At 12 months, the rate of the complications composite was 10.3% in the EBV group versus 4.6% in the control group (P=0.17). At 90 days, in the EBV group, as compared with the control group, there were increased rates of exacerbation of chronic obstructive pulmonary disease (COPD) requiring hospitalization (7.9% vs. 1.1%, P=0.03) and hemoptysis (6.1% vs. 0%, P=0.01). The rate of pneumonia in the target lobe in the EBV group was 4.2% at 12 months. Greater radiographic evidence of emphysema heterogeneity and fissure completeness was associated with an enhanced response to treatment. CONCLUSIONS: Endobronchial-valve treatment for advanced heterogeneous emphysema induced modest improvements in lung function, exercise tolerance, and symptoms at the cost of more frequent exacerbations of COPD, pneumonia, and hemoptysis after implantation. (Funded by Pulmonx; ClinicalTrials.gov number, NCT00129584.)

Published
2010

140. A MSFD complementary approach for the assessment of pressures, knowledge and data gaps in Southern European Seas: The PERSEUS experience

Author

Crise, A., primary, Kaberi, H., additional, Ruiz, J., additional, Zatsepin, A., additional, Arashkevich, E., additional, Giani, M., additional, Karageorgis, A.P., additional, Prieto, L., additional, Pantazi, M., additional, Gonzalez-Fernandez, D., additional, Ribera d’Alcalà, M., additional, Tornero, V., additional, Vassilopoulou, V., additional, Durrieu de Madron, X., additional, Guieu, C., additional, Puig, P., additional, Zenetos, A., additional, Andral, B., additional, Angel, D., additional, Altukhov, D., additional, Ayata, S.D., additional, Aktan, Y., additional, Balcıoğlu, E., additional, Benedetti, F., additional, Bouchoucha, M., additional, Buia, M.-C., additional, Cadiou, J.-F., additional, Canals, M., additional, Chakroun, M., additional, Christou, E., additional, Christidis, M.G., additional, Civitarese, G., additional, Coatu, V., additional, Corsini-Foka, M., additional, Cozzi, S., additional, Deidun, A., additional, Dell’Aquila, A., additional, Dogrammatzi, A., additional, Dumitrache, C., additional, Edelist, D., additional, Ettahiri, O., additional, Fonda-Umani, S., additional, Gana, S., additional, Galgani, F., additional, Gasparini, S., additional, Giannakourou, A., additional, Gomoiu, M.-T., additional, Gubanova, A., additional, Gücü, A.-C., additional, Gürses, Ö., additional, Hanke, G., additional, Hatzianestis, I., additional, Herut, B., additional, Hone, R., additional, Huertas, E., additional, Irisson, J.-O., additional, İşinibilir, M., additional, Jimenez, J.A., additional, Kalogirou, S., additional, Kapiris, K., additional, Karamfilov, V., additional, Kavadas, S., additional, Keskin, Ç., additional, Kideyş, A.E., additional, Kocak, M., additional, Kondylatos, G., additional, Kontogiannis, C., additional, Kosyan, R., additional, Koubbi, P., additional, Kušpilić, G., additional, La Ferla, R., additional, Langone, L., additional, Laroche, S., additional, Lazar, L., additional, Lefkaditou, E., additional, Lemeshko, I.E., additional, Machias, A., additional, Malej, A., additional, Mazzocchi, M.-G., additional, Medinets, V., additional, Mihalopoulos, N., additional, Miserocchi, S., additional, Moncheva, S., additional, Mukhanov, V., additional, Oaie, G., additional, Oros, A., additional, Öztürk, A.A., additional, Öztürk, B., additional, Panayotova, M., additional, Prospathopoulos, A., additional, Radu, G., additional, Raykov, V., additional, Reglero, P., additional, Reygondeau, G., additional, Rougeron, N., additional, Salihoglu, B., additional, Sanchez-Vidal, A., additional, Sannino, G., additional, Santinelli, C., additional, Secrieru, D., additional, Shapiro, G., additional, Simboura, N., additional, Shiganova, T., additional, Sprovieri, M., additional, Stefanova, K., additional, Streftaris, N., additional, Tirelli, V., additional, Tom, M., additional, Topaloğlu, B., additional, Topçu, N.E., additional, Tsagarakis, K., additional, Tsangaris, C., additional, Tserpes, G., additional, Tuğrul, S., additional, Uysal, Z., additional, Vasile, D., additional, Violaki, K., additional, Xu, J., additional, Yüksek, A., additional, and Papathanassiou, E., additional

Published
2015
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146. Comparison of the recent-onset arthritis disability questionnaire with the health assessment questionnaire disability index in patients with rheumatoid arthritis

Author

Salaffi, F, Ciapetti, A, Gasparini, S, Migliore, A, Scarpellini, M, Corsaro, Sm, Laganà, B, Mozzani, F, Cimmino, MARCO AMEDEO, Varcasia, G, Pusceddu, M, Castriotta, M, Serale, F, Maier, A, Foti, R, Scarpa, R, Bombardieri, S, and NEW INDICES Study Group

Subjects
Adult, Male, rheumatoid arthritis, validity, Psychometrics, patient-reported outcome, disability, road, haq-di, Reproducibility of Results, Middle Aged, HAQ, Severity of Illness Index, Arthritis, Rheumatoid, Disability Evaluation, Cross-Sectional Studies, Italy, Antirheumatic Agents, Surveys and Questionnaires, Humans, Female, Aged
Abstract

Physical disability in patients with rheumatoid arthritis (RA) is often assessed by questionnaires. We compared the Recent-Onset Arthritis Disability (ROAD) questionnaire with the Health Assessment Questionnaire (HAQ) disability index (DI) in a cohort of RA patients. The aim of this study was to obtain information on several aspects of construct validity of these measures.A cross-sectional multicentre study was carried out among patients with RA who were attending hospital outpatient clinics. The patient group included 196 patients partially or not responding to disease modifying anti-rheumatic drugs. For the evaluation of the psychometric properties of the ROAD in comparison with HAQ-DI this population has been compared to another cohort of 247 outpatients with RA who were participating in a long-term observational study. All patients completed the ROAD and HAQ-DI. Additional comparator composite indices of disease activity were analysed. The ROAD structural validity was first assessed using exploratory factor analysis. Concurrent validity was analysed by Spearman's correlations and cross-tabulations. Discriminant validity to distinguish patients with active and non-active disease was assessed with receiver operating characteristic (ROC) curve analysis. For agreement analysis Bland and Altman plots were calculated.Factor analysis yielded a two-factor ROAD score that accounted for 68.74% of the explained variance in the questionnaire. The first factor, namely upper extremity function/activity daily living and work (ROAD-upper) accounted for 55.6% of the explained variance. The second factor, namely lower extremity function (ROAD-lower) accounted for 13.1% of the explained variance. Significant correlations were found between the scores of the ROAD and the other clinical variables with a high ability to measure pain and disease activity, supporting the concept of convergent construct validity. The discriminatory power of both questionnaires to assess inactive and active RA patients was good, without significant difference.ROAD is a good alternative to the HAQ-DI for the assessment of physical disability in RA. Use of the ROAD makes it easier and less costly to collect data and reduces the burden on RA patients and should be applied in both clinical trials and routine clinical care settings.

Published
2010

150. Efficacy and safety of rituximab with and without methotrexate in the treatment of rheumatoid arthritis patients: results from the GISEA register

Author

Sebastiani, M, Anelli, Mg, Atzeni, F, Bazzani, C, Farina, I, Fedele, Anna Laura, Favalli, Eg, Fineschi, I, Cino, N, Dal Forno, I, Gasparini, S, Cassarà, E, Giardina, R, Bruschi, E, Addimanda, O, Cassone, G, Lopriore, S, Sarzi Puttini, P, Filippini, M, Pignatti, F, Gremese, Elisa, Biggioggero, M, Manganelli, S, Amato, G, Caimmi, C, Salaffi, F, Iannone, F, Ferri, C, Sandri, G, Lapadula, G, Gorla, R, Govoni, M, Ferraccioli, Gianfranco, Marchesoni, A, Galeazzi, M, Foti, R, Carletto, A, Cantini, F, Triolo, G, Epis, Om, Salvarani, C., Gremese, Elisa (ORCID:0000-0002-2248-1058), Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Sebastiani, M, Anelli, Mg, Atzeni, F, Bazzani, C, Farina, I, Fedele, Anna Laura, Favalli, Eg, Fineschi, I, Cino, N, Dal Forno, I, Gasparini, S, Cassarà, E, Giardina, R, Bruschi, E, Addimanda, O, Cassone, G, Lopriore, S, Sarzi Puttini, P, Filippini, M, Pignatti, F, Gremese, Elisa, Biggioggero, M, Manganelli, S, Amato, G, Caimmi, C, Salaffi, F, Iannone, F, Ferri, C, Sandri, G, Lapadula, G, Gorla, R, Govoni, M, Ferraccioli, Gianfranco, Marchesoni, A, Galeazzi, M, Foti, R, Carletto, A, Cantini, F, Triolo, G, Epis, Om, Salvarani, C., Gremese, Elisa (ORCID:0000-0002-2248-1058), and Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428)

Abstract

Rituximab (RTX) is a monoclonal anti-CD20 antibody approved for the treatment of rheumatoid arthritis (RA) in association with methotrexate (MTX).

Published
2014

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