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101. Bivalirudin or Heparin in Patients Undergoing Invasive Management of Acute Coronary Syndromes

Author

Gargiulo, Giuseppe, primary, Carrara, Greta, additional, Frigoli, Enrico, additional, Vranckx, Pascal, additional, Leonardi, Sergio, additional, Ciociano, Nestor, additional, Campo, Gianluca, additional, Varbella, Ferdinando, additional, Calabrò, Paolo, additional, Garducci, Stefano, additional, Iannone, Alessandro, additional, Briguori, Carlo, additional, Andò, Giuseppe, additional, Crimi, Gabriele, additional, Limbruno, Ugo, additional, Garbo, Roberto, additional, Sganzerla, Paolo, additional, Russo, Filippo, additional, Lupi, Alessandro, additional, Cortese, Bernardo, additional, Ausiello, Arturo, additional, Ierna, Salvatore, additional, Esposito, Giovanni, additional, Zavalloni, Dennis, additional, Santarelli, Andrea, additional, Sardella, Gennaro, additional, Tresoldi, Simone, additional, de Cesare, Nicoletta, additional, Sciahbasi, Alessandro, additional, Zingarelli, Antonio, additional, Tosi, Paolo, additional, van ’t Hof, Arnoud, additional, Omerovic, Elmir, additional, Brugaletta, Salvatore, additional, Windecker, Stephan, additional, and Valgimigli, Marco, additional

Published
2018
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102. Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry

Author

Iannaccone, Mario D'Ascenzo, Fabrizio Frangieh, Antonio H. and Niccoli, Giampaolo Ugo, Fabrizio Boccuzzi, Giacomo Bertaina, Maurizio Mancone, Massimo Montefusco, Antonio Amabile, Nicolas Sardella, Gennaro Motreff, Pascal Toutouzas, Konstantinos Colombo, Francesco Garbo, Roberto and Biondi-Zoccai, Giuseppe Tamburino, Corrado Omede, Pierluigi and Moretti, Claudio D'amico, Maurizio Souteyrand, Geraud and Meieir, Pascal Luescher, Thomas F. Gaita, Fiorenzo Templin, Christian

Subjects
cardiovascular diseases
Abstract

Aim. To determine the potential clinical impact of OCT (Optical Coherence Tomography) during primary percutaneous coronary intervention in patients presenting with ACS (Acute Coronary Syndrome). Methods and Results. FORMIDABLE is a multicentre retrospective registry enrolling all patients presenting with ACS and treated with an OCT-guided approach, while the USZ registry enrolled patients treated with a standard angiography guided approach. Multivariate adjustment was performed via a propensity score matching. The number stents useds was the primary outcome, while the incidence of MACE (a composite of death, myocardial infarction, target vessel revascularization, and stent thrombosis) was the secondary endpoint. A total of 285 patients OCT-guided and 1,547 angiography guided patients were enrolled, resulting in 270 for each cohort after propensity score with matching. Two stents were used in 12% versus 34%; 3 stents in 8% versus 38% of the patients (P

Published
2017

103. Diagnostic accuracy of functional, imaging and biochemical tests for patients presenting with chest pain to the emergency department: A systematic review and meta-analysis

Author

Iannaccone, Mario, primary, Gili, Sebastiano, additional, De Filippo, Ovidio, additional, D’Amico, Salvatore, additional, Gagliardi, Marco, additional, Bertaina, Maurizio, additional, Mazzilli, Silvia, additional, Rettegno, Sara, additional, Bongiovanni, Federica, additional, Gatti, Paolo, additional, Ugo, Fabrizio, additional, Boccuzzi, Giacomo G, additional, Colangelo, Salvatore, additional, Prato, Silvia, additional, Moretti, Claudio, additional, D’Amico, Maurizio, additional, Noussan, Patrizia, additional, Garbo, Roberto, additional, Hildick-Smith, David, additional, Gaita, Fiorenzo, additional, and D’Ascenzo, Fabrizio, additional

Published
2018
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104. Single-staged compared with multi-staged PCI in multivessel NSTEMI patients. the SMILE trial

Author

Sardella, Gennaro, Lucisano, Luigi, Garbo, Roberto, Pennacchi, Mauro, Cavallo, Erika, Stio, Rocco Edoardo, Calcagno, Simone, Ugo, Fabrizio, Boccuzzi, Giacomo, Fedele, Francesco, and Mancone, Massimo

Subjects
acute coronary syndrome, coronary artery disease, intention-to-treat analysis, myocardial infarction, myocardial ischemia, troponin, cardiovascular diseases
Abstract

BackgroundA lack of clarity exists about the role of complete coronary revascularization in patients presenting with non–ST-segment elevation myocardial infarction.ObjectivesThe aim of our study was to compare long-term outcomes in terms of major adverse cardiovascular and cerebrovascular events of 2 different complete coronary revascularization strategies in patients with non–ST-segment elevation myocardial infarction and multivessel coronary artery disease: 1-stage percutaneous coronary intervention (1S-PCI) during the index procedure versus multistage percutaneous coronary intervention (MS-PCI) complete coronary revascularization during the index hospitalization.MethodsIn the SMILE (Impact of Different Treatment in Multivessel Non ST Elevation Myocardial Infarction Patients: One Stage Versus Multistaged Percutaneous Coronary Intervention) trial, 584 patients were randomly assigned in a 1:1 manner to 1S-PCI or MS-PCI. The primary study endpoint was the incidence of major adverse cardiovascular and cerebrovascular events, which were defined as cardiac death, death, reinfarction, rehospitalization for unstable angina, repeat coronary revascularization (target vessel revascularization), and stroke at 1 year.ResultsThe occurrence of the primary endpoint was significantly lower in the 1-stage group (1S-PCI: n = 36 [13.63%] vs. MS-PCI: n = 61 [23.19%]; hazard ratio [HR]: 0.549 [95% confidence interval (CI): 0.363 to 0.828]; p = 0.004). The 1-year rate of target vessel revascularization was significantly higher in the MS-PCI group (1S-PCI: n = 22 [8.33%] vs. MS-PCI: n = 40 [15.20%]; HR: 0.522 [95% CI: 0.310 to 0.878]; p = 0.01; p log-rank = 0.013). When the analyses were limited to cardiac death (1S-PCI: n = 9 [3.41%] vs. MS-PCI: n = 14 [5.32%]; HR: 0.624 [95% CI: 0.270 to 1.441]; p = 0.27) and myocardial infarction (1S-PCI: n = 7 [2.65%] vs. MS-PCI: n = 10 [3.80%]; HR: 0.678 [95% CI: 0.156 to 2.657]; p = 0.46), no significant differences were observed between groups.ConclusionsIn multivessel non–ST-segment elevation myocardial infarction patients, complete 1-stage coronary revascularization is superior to multistage PCI in terms of major adverse cardiovascular and cerebrovascular events. (Impact of Different Treatment in Multivessel Non ST Elevation Myocardial Infarction [NSTEMI] Patients: One Stage Versus Multistaged Percutaneous Coronary Intervention [PCI] [SMILE]: NCT01478984)

Published
2016

106. Impact of design of coronary stents and length of dual antiplatelet therapies on ischaemic and bleeding events: a network meta-analysis of 64 randomized controlled trials and 102 735 patients

Author

D’Ascenzo, Fabrizio, primary, Iannaccone, Mario, additional, Saint-Hilary, Gaelle, additional, Bertaina, Maurizio, additional, Schulz-Schüpke, Stefanie, additional, Wahn Lee, Cheol, additional, Chieffo, Alaide, additional, Helft, Gerard, additional, Gili, Sebastiano, additional, Barbero, Umberto, additional, Biondi Zoccai, Giuseppe, additional, Moretti, Claudio, additional, Ugo, Fabrizio, additional, D’Amico, Maurizio, additional, Garbo, Roberto, additional, Stone, Gregg, additional, Rettegno, Sara, additional, Omedè, Pierluigi, additional, Conrotto, Federico, additional, Templin, Christian, additional, Colombo, Antonio, additional, Park, Seung-jung, additional, Kastrati, Adnan, additional, Hildick-Smith, David, additional, Gasparini, Mauro, additional, and Gaita, Fiorenzo, additional

Published
2017
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107. Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry

Author

Barbero, Umberto, primary, Scacciatella, Paolo, additional, Iannaccone, Mario, additional, D'Ascenzo, Fabrizio, additional, Niccoli, Giampaolo, additional, Colombo, Francesco, additional, Ugo, Fabrizio, additional, Colangelo, Salvatore, additional, Mancone, Massimo, additional, Calcagno, Simone, additional, Sardella, Gennaro, additional, Amabile, Nicolas, additional, Motreff, Pascal, additional, Toutouzas, Konstantinos, additional, Garbo, Roberto, additional, Tamburino, Corrado, additional, Montefusco, Antonio, additional, Omedè, Pierluigi, additional, Moretti, Claudio, additional, D'amico, Maurizio, additional, Souteyrand, Geraud, additional, Gaita, Fiorenzo, additional, and Templin, Christian, additional

Published
2017
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108. Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry

Author

Gili, Sebastiano, primary, Iannaccone, Mario, additional, Colombo, Francesco, additional, Montefusco, Antonio, additional, Amabile, Nicolas, additional, Calcagno, Simone, additional, Capodanno, Davide, additional, Scalone, Giancarla, additional, Rognoni, Andrea, additional, Omedè, Pierluigi, additional, Ugo, Fabrizio, additional, Cavallo, Erika, additional, Mancone, Massimo, additional, Mangiameli, Andrea, additional, Boccuzzi, Giacomo, additional, Hiansen, Joshua, additional, Motreff, Pascal, additional, Toutouzas, Konstantinos, additional, Garbo, Roberto, additional, Sardella, Gennaro, additional, Tamburino, Corrado, additional, D’Amico, Maurizio, additional, Moretti, Claudio, additional, Templin, Christian, additional, Gaita, Fiorenzo, additional, Souteyrand, Geraud, additional, Niccoli, Giampaolo, additional, and D’Ascenzo, Fabrizio, additional

Published
2017
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109. Prevalence and outcome of patients with cancer and acute coronary syndrome undergoing percutaneous coronary intervention: a BleeMACS substudy

Author

Iannaccone, Mario, primary, D’Ascenzo, Fabrizio, additional, Vadalà, Paolo, additional, Wilton, Stephen B, additional, Noussan, Patrizia, additional, Colombo, Francesco, additional, Raposeiras Roubín, Sergio, additional, Abu Assi, Emad, additional, González-Juanatey, José Ramón, additional, Simao Henriques, Jose Paulo, additional, Saucedo, Jorge, additional, Kikkert, Wouter J, additional, Nuñez-Gil, Iván, additional, Ariza-Sole, Albert, additional, Song, Xian-tao, additional, Alexopoulos, Dimitrios, additional, Liebetrau, Christoph, additional, Kawaji, Tetsuma, additional, Moretti, Claudio, additional, Garbo, Roberto, additional, Huczek, Zenon, additional, Nie, Shao-Ping, additional, Fujii, Toshiharu, additional, Correia, Luis CL, additional, Kawashiri, Masa-aki, additional, García Acuña, José María, additional, Southern, Danielle, additional, Alfonso, Emilio, additional, Terol, Belén, additional, Garay, Alberto, additional, Zhang, Dongfeng, additional, Chen, Yalei, additional, Xanthopoulou, Ioanna, additional, Osman, Neriman, additional, Möllmann, Helge, additional, Shiomi, Hiroki, additional, Giordana, Francesca, additional, Kowara, Michal, additional, Filipiak, Krzysztof, additional, Wang, Xiao, additional, Yan, Yan, additional, Fan, Jing-Yao, additional, Ikari, Yuji, additional, Nakahashi, Takuya, additional, Sakata, Kenji, additional, Gaita, Fiorenzo, additional, Yamagishi, Masakazu, additional, Kalpak, Oliver, additional, and Kedev, Sasko, additional

Published
2017
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110. Acute Kidney Injury After Radial or Femoral Access for Invasive Acute Coronary Syndrome Management

Author

Andò, Giuseppe, primary, Cortese, Bernardo, additional, Russo, Filippo, additional, Rothenbühler, Martina, additional, Frigoli, Enrico, additional, Gargiulo, Giuseppe, additional, Briguori, Carlo, additional, Vranckx, Pascal, additional, Leonardi, Sergio, additional, Guiducci, Vincenzo, additional, Belloni, Flavia, additional, Ferrari, Fabio, additional, de la Torre Hernandez, Jose Maria, additional, Curello, Salvatore, additional, Liistro, Francesco, additional, Perkan, Andrea, additional, De Servi, Stefano, additional, Casu, Gavino, additional, Dellavalle, Antonio, additional, Fischetti, Dionigi, additional, Micari, Antonio, additional, Loi, Bruno, additional, Mangiacapra, Fabio, additional, Russo, Nunzio, additional, Tarantino, Fabio, additional, Saia, Francesco, additional, Heg, Dik, additional, Windecker, Stephan, additional, Jüni, Peter, additional, Valgimigli, Marco, additional, Salomone, Maria, additional, Occhilupo, Pierpaolo, additional, Lodolini, Veronica, additional, Monti, Monia, additional, Mazzone, Maria Grazia, additional, Delos, Erika, additional, Caruso, Maria Teresa, additional, Testa, Maggie, additional, Ciociano, Nestor, additional, Lazzero, Maurizio, additional, Gazzotti, Davide, additional, Cagliari, Lorenzo, additional, Shahmohammadi, Leila, additional, Caiazza, Martina, additional, Virga, Vittorio, additional, Guerra, Elena, additional, Michalska, Eva, additional, Castellini, Sara, additional, Serino, Vincenzo, additional, Visconti, Gabriella, additional, Pendenza, Gianluca, additional, Portolan, Monica, additional, Anzini, Marco, additional, Silvetti, Elisa, additional, Coco, Tiziana, additional, Costa, Francesco, additional, Ariotti, Sara, additional, Valli, Linda, additional, Adamo, Marianna, additional, Marino, Marcello, additional, Tricoci, Pierluigi, additional, Gagnor, Andrea, additional, Calabrò, Paolo, additional, Rubartelli, Paolo, additional, Garducci, Stefano, additional, Andò, Giuseppe, additional, Santarelli, Andrea, additional, Galli, Mario, additional, Garbo, Roberto, additional, Bramucci, Ezio, additional, Ierna, Salvatore, additional, Limbruno, Ugo, additional, Violini, Roberto, additional, Presbitero, Patrizia, additional, de Cesare, Nicoletta, additional, Sganzerla, Paolo, additional, Ausiello, Arturo, additional, Tosi, Paolo, additional, Sardella, Gennaro, additional, Sabate’, Manel, additional, Brugaletta, Salvatore, additional, Saccone, Giovanni, additional, Vandoni, Pietro, additional, Zingarelli, Antonio, additional, Liso, Armando, additional, Rigattieri, Stefano, additional, Di Lorenzo, Emilio, additional, Vigna, Carlo, additional, Palmieri, Cataldo, additional, Falcone, Camillo, additional, De Caterina, Raffaele, additional, Caputo, Marcello, additional, Esposito, Giovanni, additional, Lupi, Alessandro, additional, Mazzarotto, Pietro, additional, Varbella, Fernando, additional, Zaro, Tiziana, additional, Nazzaro, Marco, additional, Rao, Sunil V., additional, van‘t Hof, Arnoud W.J., additional, Omerovic, Elmir, additional, Campo, Gianluca, additional, Uguccioni, Lucia, additional, Tamburino, Corrado, additional, Zavalloni-Parenti, Dennis, additional, Ceravolo, Roberto, additional, Pasquetto, Giampaolo, additional, Mameli, Stefano, additional, Stochino, Maria Letizia, additional, Cremonesi, Alberto, additional, abate, Fabio, additional, Picchi, Andrea, additional, Colangelo, Salvatore, additional, Boccuzzi, Giacomo, additional, Varbella, Ferdinando, additional, Tresoldi, Stefano, additional, Contarini, Marco, additional, Evola, Rosario, additional, Creaco, Manuela, additional, Colombo, Antonio, additional, Chieffo, Alaide, additional, Sciahbasi, Alessandro, additional, Pucci, Edoardo, additional, Romagnoli, Enrico, additional, Moretti, Claudio, additional, Moretti, Luciano, additional, Zimmarino, Marco, additional, Ferrario, Maurizio, additional, Turturo, Maurizio, additional, Bonmassari, Roberto, additional, Penzo, Carlo, additional, Mauro, Ciro, additional, Petronio, Anna Sonia, additional, Gabrielli, Gabriele, additional, Amico, Francesco, additional, Comeglio, Marco, additional, Fresco, Claudio, additional, Van Mieghem, Nicolas, additional, Diletti, Roberto, additional, Regar, Evelyn, additional, Sabaté, Manel, additional, Gómez Hospital, Joan Antoni, additional, Díaz Fernández, José Francisco, additional, and Mainar, Vicente, additional

Published
2017
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112. PROVISIONAL VERSUS ELECTIVE TWO-STENTING STRATEGY FOR UNPROTECTED TRUE LEFT MAIN BIFURCATION LESIONS: A SUB-STUDY FROM FAILS 2 STUDY

Author

Kawamoto, Hiroyoshi, primary, Chieffo, Alaide, additional, Jabbour, Richard, additional, D'Ascenzo, Fabrizio, additional, Cerrato, Enrico, additional, Ugo, Fabrizio, additional, Pavani, Marco, additional, di Summa, Roberto, additional, Varbella, Ferdinando, additional, Boccuzzi, Giacomo, additional, Omedè, Pierluigi, additional, Garbo, Roberto, additional, Conrotto, Federico, additional, Montefusco, Antonio, additional, Biondi-Zoccai, Giuseppe, additional, D'Amico, Maurizio, additional, Moretti, Claudio, additional, Escaned, Javier, additional, Gaita, Fiorenzo, additional, Nakamura, Sunao, additional, and Colombo, Antonio, additional

Published
2017
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114. Absorbable Polymer Technology – Viable Solutions for Unmet Needs in PCI: Proceedings of two satellite symposia held at EuroPCR, Paris in May 2015

Author

Mountfort, Katrina, Khashaba, Ahmed, Garbo, Roberto, Tigen, Kurstat, Moellmann, Helge, and Morice, Marie-Claude

Subjects
Supported Contribution
Abstract

The use of drug-eluting stents (DES) has improved clinical outcomes in percutaneous coronary intervention procedures, but many challenges remain. In two symposia at EuroPCR 2015, the factors necessary to ensure successful chronic total occlusion (CTO) intervention were presented. Good preparation, sufficient operator experience and the correct approach are key to the success of CTO interventions. A live case demonstrated the challenges of these complex cases. Stent choice in CTO interventions is crucial; second-generation DES are associated with lower rates of restenosis and re-occlusion compared with first-generation DES. The Coracto™ DES features unique structural properties and rapidly absorbable polymer, resulting in excellent conformability, efficacy and safety.

Published
2015

115. Rotational atherectomy in very long lesions: Results for the ROTATE registry

Author

Iannaccone, Mario, Barbero, Umberto, D'Ascenzo, Fabrizio, Latib, Azeem, Pennacchi, Mauro, Rossi, Marco Luciano, Ugo, Fabrizio, Meliga, Emanuele, Kawamoto, Hiroyoshi, Moretti, Claudio, Ielasi, Alfonso, Garbo, Roberto, Colombo, Antonio, Boccuzzi, Giacomo G., and Sardella, Gennaro

Subjects
Atherectomy, Coronary, Male, calcific lesion, Atherectomy, Time Factors, Coronary, Coronary Artery Disease, Coronary Angiography, Severity of Illness Index, rotablator, rotational atherectomy, second-generation DES, Aged, Female, Follow-Up Studies, Humans, Percutaneous Coronary Intervention, Retrospective Studies, Treatment Outcome, Registries, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, Nuclear Medicine and Imaging, medicine (all), radiology, nuclear medicine and imaging, cardiology and cardiovascular medicine, Radiology
Abstract

Rotational atherectomy (RA) is relatively contraindicated in patients with lesions ≥25 mm of length. Aim of this study was to evaluate RA safety and efficacy in this subset of patients with new technology and devices.From April 2002 to August 2013, the ROTATE registry included all consecutive patients undergoing RA in 8 centres. They were divided into shorter lesion group (SLG, lesions 25 mm) and longer lesion group (LLG, lesions ≥ 25 mm). The angiographic success (AS) was the primary end point. Procedural complications (PC), a composite end point of procedural perforation, slow flow/no flow, and in-hospital major acute cardiovascular events (MACE), were secondary end points, along with death, nonfatal MI, target lesion revascularization, and MACE during follow-up. Sensitivity analysis was performed according to generation of DES. 1186 patients were included: 51.5% in SLG and 48.4% in LLG. Mean age was 70.4 ± 9.3 years, 64.5% were male. AS and PC did not differ between the two groups (93% vs 91%, p = 0.24 and 9.8 vs 9.4%, p = 0.84). During follow-up (27.6 ± 22.9 months), MACE did not differ between the two groups (28% vs 29.1%, p = 0.95). At multivariate analysis chronic kidney disease, male gender increased risk of MACE (HR 1.94, IQR 1.29-2.0, p = 0.01, HR 0.52, IQR 0.34-0.79, p = 0.01) while second-generation DES seemed protective (HR 0.53, IQR 0.31-0.88, p = 0.02). Data were confirmed at sensitivity analysis for second-generation DES (759 pts, 63.9%). No differences were found in this subpopulation between the two groups in term of AS, PC, and long-term MACE (93.6% vs 93.5%, p = 0.28, 11.9% vs 9.4%, p = 0.32 and 25.5% vs 23.9%, p = 0.72, respectively).Treating coronary lesions ≥ 25 mm length with RA does not impact short- and long-term outcome, in particular, in patients with second-generation DES. © 2016 Wiley Periodicals, Inc.

Published
2015

118. Retrograde Recanalization of Chronic Total Occlusions in Europe : procedural, In-Hospital, and Long-Term Outcomes From the Multicenter ERCTO Registry

Author

Galassi, Alfredo, Sianos, Georgios, Werner, Gerald, Escaned, Javier, Tomasello, Salvatore, Boukhris, Marouane, Castaing, Marine, Buttner, Joachim, Bufe, Alexander, Kalnins, Artis, Spratt, James, Garbo, Roberto, Hildick-Smith, David, Elhadad, Simon, Gagnor, Andrea, Lauer, Bernward, Bryniarski, Leszek, Christiansen, Evald, Thuesen, Leif, Meyer-Gessner, Markus, Goktekin, Omer, Carlino, Mauro, Louvard, Yves, Lefevre, Thierry, Lismanis, Aigars, Gelev, Valery, Serra, Antonio, Marza, Francesco, Di Mario, Carlo, Reifart, Nicolaus, and the Euro CTO Club

Published
2015

119. Contemporary Techniques for Coronary Chronic Total Occlusions Revascularisation: Sharing Experience in a Global World: Proceedings of a satellite symposium held at EuroPCR on May 20th – 23rd 2014 in Paris Katrina Mountfort, Medical Writer, Radcliffe Cardiology

Author

Mountfort, Katrina, Joachim Büttner, Heinz, Yamane, Masahisa, Reifart, Nicolaus, Escaned, Javier, Sianos, Georgios, Goktekin, Omer, and Garbo, Roberto

Subjects
Coronary CTO, cardiovascular diseases
Abstract

Chronic total occlusions (CTO) are the most challenging lesions treated by interventional cardiologists. A symposium at EuroPCR 2014 discussed factors influencing the success of percutaneous intervention (PCI) in CTO. Current treatment paradigms suggest that one or two vessel disease should be treated by PCI while three-vessel disease requires surgery if complete revascularisation cannot be achieved with PCI. In patients with CTO and multi-vessel disease timing is key, and evidence of ischaemic burden and expected completeness of revascularisation is required before PCI is undertaken. Other factors affecting procedural success include the available equipment and expertise of the operator. Flexiblity in strategy selection is also important as it is frequently necessary to switch strategies during the procedure. The presentation included two live cases that illustrated the complexity of this procedure.

Published
2014

122. DESolve novolimus-eluting bioresorbable coronary scaffold failure assessed by frequency-domain optical coherence tomography imaging

Author

Porto, Italo, Vergallo, Rocco, Sangiorgi, Giuseppe M, Burzotta, Francesco, Garbo, Roberto, D'Amario, Domenico, Trani, Carlo, Rebuzzi, Antonio Giuseppe, Crea, Filippo, Porto, Italo (ORCID:0000-0002-9854-5046), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Rebuzzi, Antonio Giuseppe (ORCID:0000-0002-9873-957X), Crea, Filippo (ORCID:0000-0001-9404-8846), Porto, Italo, Vergallo, Rocco, Sangiorgi, Giuseppe M, Burzotta, Francesco, Garbo, Roberto, D'Amario, Domenico, Trani, Carlo, Rebuzzi, Antonio Giuseppe, Crea, Filippo, Porto, Italo (ORCID:0000-0002-9854-5046), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Rebuzzi, Antonio Giuseppe (ORCID:0000-0002-9873-957X), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

N/A

Published
2016

123. ROTational AThErectomy in acute coronary syndrome: early and midterm outcomes from a multicentre registry

Author

Iannaccone, Mario, Piazza, Fabio, Boccuzzi, Giacomo G, D'Ascenzo, Fabrizio, Latib, Azeem, Pennacchi, Mauro, Rossi, Marco Luciano, Ugo, Fabrizio, Meliga, Emanuele, Kawamoto, Hiroyoshi, Moretti, Claudio, Ielasi, Alfonso, Garbo, Roberto, Frangieh, Antonio H, Hildick-Smith, David, Templin, Christian, Colombo, Antonio, Sardella, Gennaro, Iannaccone, Mario, Piazza, Fabio, Boccuzzi, Giacomo G, D'Ascenzo, Fabrizio, Latib, Azeem, Pennacchi, Mauro, Rossi, Marco Luciano, Ugo, Fabrizio, Meliga, Emanuele, Kawamoto, Hiroyoshi, Moretti, Claudio, Ielasi, Alfonso, Garbo, Roberto, Frangieh, Antonio H, Hildick-Smith, David, Templin, Christian, Colombo, Antonio, and Sardella, Gennaro

Published
2016

124. Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter 'real-world' registry

Author

Imori, Yoichi, D'Ascenzo, Fabrizio, Gori, Tommaso, Münzel, Thomas, Fabrizio, Ugo, Campo, Gianluca, Cerrato, Enrico, Napp, L Christian, Iannaccone, Mario, Ghadri, Jelena R, Kazemian, Elycia, Binder, Ronald K, Jaguszewski, Milosz, Csordas, Adam, Capasso, Piera, Biscaglia, Simone, Conrotto, Fedrico, Varbella, Ferdinando, Garbo, Roberto, Gaita, Fiorenzo, Erne, Paul, Lüscher, Thomas F, Moretti, Claudio, Frangieh, Antonio H, Templin, Christian, Imori, Yoichi, D'Ascenzo, Fabrizio, Gori, Tommaso, Münzel, Thomas, Fabrizio, Ugo, Campo, Gianluca, Cerrato, Enrico, Napp, L Christian, Iannaccone, Mario, Ghadri, Jelena R, Kazemian, Elycia, Binder, Ronald K, Jaguszewski, Milosz, Csordas, Adam, Capasso, Piera, Biscaglia, Simone, Conrotto, Fedrico, Varbella, Ferdinando, Garbo, Roberto, Gaita, Fiorenzo, Erne, Paul, Lüscher, Thomas F, Moretti, Claudio, Frangieh, Antonio H, and Templin, Christian

Abstract

BACKGROUND: Safety and efficacy of bioresorbable vascular scaffolds (BRS) and the role of postdilatation on outcome in acute coronary syndrome (ACS) patients compared with those of everolimus-eluting stents (EES) remain unknown. The aim of the study is to compare the safety and efficacy of BRS with EES in ACS and to investigate the role of BRS postdilatation. METHODS: Consecutive ACS patients undergoing BRS implantation in 8 centers were com-pared with those with EES before and after propensity score matching. Major adverse cardiac event (MACE), myocardial infarction, and target lesion revascularization (TLR) were the primary endpoint. Sensitivity analysis was performed according to postdilatation after BRS implantation. We enrolled 303 BRS and 748 EES patients; 215 from each group were com-pared after matching, and 117 (55.2%) BRS patients were treated with postdilatation. RESULTS: After a median follow-up of 24.0 months, MACE rates were higher in BRS patients than in EES patients (9.3% vs. 4.7%, p < 0.001), mainly driven by TLR (6.1% vs. 1.9%, p < 0.001). Stent thrombosis increased in the BRS group (2.8% vs. 0.9%, p = 0.01). How-ever, after sensitivity analysis, MACE rates in BRS patients with postdilatation were signifi-cantly lower than in those without, comparable to EES patients (6.0% vs. 12.6% vs. 4.7%, p < 0.001). The same trend was observed for TLR (3.4% vs. 8.4% vs. 1.9%, p < 0.001). Stent thrombosis rates were higher in both the BRS groups than in EES patients (2.6% vs. 3.2% vs. 0.9%, p = 0.045). CONCLUSIONS: Postdilatation appears effective when using BRS in ACS patients. MACE rates are comparable to those of EES, although scaffold thrombosis is not negligible. Randomized prospective studies are required for further investigation.

Published
2016

125. Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE‐CARDIOGROUP IV and USZ registry

Author

Iannaccone, Mario, primary, D'Ascenzo, Fabrizio, additional, Frangieh, Antonio H., additional, Niccoli, Giampaolo, additional, Ugo, Fabrizio, additional, Boccuzzi, Giacomo, additional, Bertaina, Maurizio, additional, Mancone, Massimo, additional, Montefusco, Antonio, additional, Amabile, Nicolas, additional, Sardella, Gennaro, additional, Motreff, Pascal, additional, Toutouzas, Konstantinos, additional, Colombo, Francesco, additional, Garbo, Roberto, additional, Biondi‐Zoccai, Giuseppe, additional, Tamburino, Corrado, additional, Omedè, Pierluigi, additional, Moretti, Claudio, additional, D'amico, Maurizio, additional, Souteyrand, Geraud, additional, Meieir, Pascal, additional, Lüscher, Thomas F., additional, Gaita, Fiorenzo, additional, and Templin, Christian, additional

Published
2016
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126. ROTational AThErectomy in acute coronary syndrome: early and midterm outcomes from a multicentre registry

Author

Iannaccone, Mario, primary, Piazza, Fabio, additional, Boccuzzi, Giacomo, additional, D’Ascenzo, Fabrizio, additional, Latib, Azeem, additional, Pennacchi, Mauro, additional, Rossi, Marco Luciano, additional, Ugo, Fabrizio, additional, Meliga, Emanuele, additional, Kawamoto, Hiroyoshi, additional, Moretti, Claudio, additional, Ielasi, Alfonso, additional, Garbo, Roberto, additional, Frangieh, Antonio, additional, Hildick-Smith, David, additional, Templin, Christian, additional, Colombo, Antonio, additional, and Sardella, Gennaro, additional

Published
2016
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127. In-hospital and midterm clinical outcomes of rotational atherectomy followed by stent implantation: the ROTATE multicentre registry

Author

Kawamoto, Hiroyoshi, primary, Latib, Azeem, additional, Ruparelia, Neil, additional, Ielasi, Alfonso, additional, D’Ascenzo, Fabrizio, additional, Pennacchi, Mauro, additional, Sardella, Gennaro, additional, Garbo, Roberto, additional, Meliga, Emanuele, additional, Moretti, Claudio, additional, Rossi, Marco, additional, Presbitero, Patrizia, additional, Magri, Caroline, additional, Nakamura, Sunao, additional, Colombo, Antonio, additional, and Boccuzzi, Giacomo, additional

Published
2016
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128. TCT-204 Optimal duration of dual antiplatelet therapy (DAPT) after second generation drug-eluting stent (DES) implantation in elderly patients: the SECURITY-ELDERLY substudy

Author

Ferri, Luca Angelo, primary, Chieffo, Alaide, additional, Giustino, Gennaro, additional, Frasheri, Arian, additional, Garbo, Roberto, additional, Masotti-Centol, Monica, additional, Salvatella, Neus, additional, Oteo Dominguez, Juan Francisco, additional, Steffanon, Luigi, additional, Tarantini, Giuseppe, additional, Presbitero, Patrizia, additional, Menozzi, Alberto, additional, Pucci, Edoardo, additional, Mauri, Josepa, additional, Sardella, Gennaro, additional, and Colombo, Antonio, additional

Published
2016
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129. Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter “real-world” registry

Author

Imori, Yoichi, primary, D'Ascenzo, Fabrizio, additional, Gori, Tommaso, additional, Münzel, Thomas, additional, Fabrizio, Ugo, additional, Campo, Gianluca, additional, Cerrato, Enrico, additional, Napp, L. Christian, additional, Iannaccone, Mario, additional, Ghadri, Jelena R., additional, Kazemian, Elycia, additional, Binder, Ronald K., additional, Jaguszewski, Milosz, additional, Csordas, Adam, additional, Capasso, Piera, additional, Biscaglia, Simone, additional, Conrotto, Fedrico, additional, Varbella, Ferdinando, additional, Garbo, Roberto, additional, Gaita, Fiorenzo, additional, Erne, Paul, additional, Lüscher, Thomas F., additional, Moretti, Claudio, additional, Frangieh, Antonio H., additional, and Templin, Christian, additional

Published
2016
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132. Rotational atherectomy in very long lesions: Results for the ROTATE registry

Author

Iannaccone, Mario, primary, Barbero, Umberto, additional, D'ascenzo, Fabrizio, additional, Latib, Azeem, additional, Pennacchi, Mauro, additional, Rossi, Marco Luciano, additional, Ugo, Fabrizio, additional, Meliga, Emanuele, additional, Kawamoto, Hiroyoshi, additional, Moretti, Claudio, additional, Ielasi, Alfonso, additional, Garbo, Roberto, additional, Colombo, Antonio, additional, Sardella, Gennaro, additional, and Boccuzzi, Giacomo G., additional

Published
2016
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134. Second-generation drug-eluting stent implantation followed by 6- versus 12-month dual antiplatelet therapy: the SECURITY randomized clinical trial

Author

Colombo, Antonio, Chieffo, Alaide, Frasheri, Arian, Garbo, Roberto, Masotti-Centol, Monica, Salvatella, Neus, Oteo Dominguez, Juan Francisco, Steffanon, Luigi, Tarantini, Giuseppe, Presbitero, Patrizia, Menozzi, Alberto, Pucci, Edoardo, Mauri, Josepa, Cesana, Bruno Mario, Giustino, Gennaro, and Sardella, Gennaro

Subjects
stents, percutaneous coronary intervention, platelet aggregation inhibitors, coronary artery disease, prospective studies, thrombosis
Abstract

BackgroundThe optimal duration of dual antiplatelet therapy (DAPT) following second-generation drug-eluting stent (DES) implantation is still debated.ObjectivesThe aim of this study was to test the noninferiority of 6 versus 12 months of DAPT in patients undergoing percutaneous coronary intervention with second-generation DES.MethodsThe SECURITY (Second Generation Drug-Eluting Stent Implantation Followed by Six- Versus Twelve-Month Dual Antiplatelet Therapy) trial was a 1:1 randomized, multicenter, international, investigator-driven, noninferiority study conducted from July 2009 to June 2014. Patients with a stable or unstable angina diagnosis or documented silent ischemia undergoing revascularization with at least 1 second-generation DES were eligible. The primary endpoint was a composite of cardiac death, myocardial infarction (MI), stroke, definite or probable stent thrombosis, or Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding at 12 months. The main secondary endpoint was a composite of cardiac death, MI, stroke, definite or probable stent thrombosis, or BARC type 2, 3, or 5 bleeding at 12 and 24 months.ResultsOverall, 1,399 patients were enrolled in the study and randomized to receive 6 months (n = 682) versus 12 months (n = 717) DAPT. The primary composite endpoint occurred, respectively, in 4.5% versus 3.7% (risk difference 0.8%; 95% confidence interval [CI]: −2.4% to 1.7%; p = 0.469) at 12 months. The upper 95% CI limit was lower than the pre-set margin of 2%, confirming the noninferiority hypothesis (p < 0.05). Moreover, no differences were observed in the occurrence of the secondary endpoint at 12 months (5.3% vs. 4.0%, difference: 1.2%; 95% CI: −1.0 to 3.4; p = 0.273) and between 12 and 24 months (1.5% vs. 2.2%, difference: −0.7%; 95% CI: −2.1 to 0.6; p = 0.289). Finally, no differences were observed in definite or probable stent thrombosis at 12 months (0.3% vs. 0.4%; difference: −0.1%; 95% CI: −0.7 to 0.4; p = 0.694) and between 12 and 24 months of follow-up (0.1% vs. 0%; difference: 0.1%; 95% CI: −0.1 to 0.4; p = 0.305).ConclusionsIn a low-risk population, the noninferiority hypothesis of 6 vs. 12 months DAPT following second-generation DES implantation appears accepted for the incidence of cardiac death, MI, stroke, definite/probable stent thrombosis, and BARC type 3 or 5 bleeding at 12 months. (Second Generation Drug-Eluting Stent Implantation Followed by Six- Versus Twelve-Month Dual Antiplatelet Therapy; NCT00944333)

Published
2014

135. Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry.

Author

Barbero, Umberto, Scacciatella, Paolo, Iannaccone, Mario, D'Ascenzo, Fabrizio, Niccoli, Giampaolo, Colombo, Francesco, Ugo, Fabrizio, Colangelo, Salvatore, Mancone, Massimo, Calcagno, Simone, Sardella, Gennaro, Amabile, Nicolas, Motreff, Pascal, Toutouzas, Konstantinos, Garbo, Roberto, Tamburino, Corrado, Montefusco, Antonio, Omedè, Pierluigi, Moretti, Claudio, and D'amico, Maurizio

Published
2018
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136. Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry.

Author

Gili, Sebastiano, Iannaccone, Mario, Colombo, Francesco, Montefusco, Antonio, Amabile, Nicolas, Calcagno, Simone, Capodanno, Davide, Scalone, Giancarla, Rognoni, Andrea, Omedè, Pierluigi, Ugo, Fabrizio, Cavallo, Erika, Mancone, Massimo, Mangiameli, Andrea, Boccuzzi, Giacomo, Hiansen, Joshua, Motreff, Pascal, Toutouzas, Konstantinos, Garbo, Roberto, and Sardella, Gennaro

Subjects
ATHEROSCLEROSIS, CONFIDENCE intervals, DIABETES, HYPERLIPIDEMIA, LIPIDS, MYOCARDIAL infarction, PREANESTHETIC medication, STATINS (Cardiovascular agents), OPTICAL coherence tomography, RETROSPECTIVE studies, ACUTE coronary syndrome, ODDS ratio, PHARMACODYNAMICS
Abstract

Aims Chronic pre-treatment with statins may reduce mortality and morbidity in patients experiencing acute coronary syndromes (ACS), but mechanisms accounting for these findings are not completely understood. Methods and results The optical coherence tomography (OCT)-Formidable registry retrospectively enrolled 285 consecutive patients with ACS undergoing OCT in 9 European centres. Mean age was 60.4 ° 12.8 years, 148 (51.9%) patients had hyperlipemia, 45 (15.8%) diabetes mellitus and 142 (49.8%) presented with ST Segment Elevation Myocardial Infarction (STEMI). Patients were stratified according to statin prescription: 150 (52.6%) were on chronic pretreatment with statins before ACS and were more likely to present with non-ST segment elevation acute coronary syndromes (NSTE-ACS) at admission (111, 74%) rather than STEMI, while the opposite was observed for patients not on statins. The primary end-point of ruptured plaque at OCT occurred significantly less frequently in the patients on chronic pre-treatment with statins [odds ratio (OR) 0.375, 95% confidence interval (CI) 0.185-0.759, P = 0.006]. The secondary end-point of thin-cap fibro-atheroma (TCFA) at any site was significantly less frequent in the statin group (OR 0.423, 95%CI 0.213-0.840, P = 0.014). No differences were observed for the secondary endpoint of not-ruptured TCFA as the culprit lesion. Pre-specified sensitivity analysis was conducted according to the pattern of ACS: the reported differences were confirmed for NSTE-ACS patients, with a trend towards less plaque rupture and a significant reduction of TCFA at any site with statins, but not for STEMI. Conclusions Chronic pre-treatment with statins is associated with a reduced prevalence of ruptured plaques in patients presenting with ACS, particularly in those with NSTE-ACS. Statins bear hence the potential to reduce morbidity during the acute phase of ACS. [ABSTRACT FROM AUTHOR]

Published
2018
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137. Diagnostic accuracy of functional, imaging and biochemical tests for patients presenting with chest pain to the emergency department: A systematic review and meta-analysis

Author

Iannaccone, Mario, Gili, Sebastiano, De Filippo, Ovidio, D’Amico, Salvatore, Gagliardi, Marco, Bertaina, Maurizio, Mazzilli, Silvia, Rettegno, Sara, Bongiovanni, Federica, Gatti, Paolo, Ugo, Fabrizio, Boccuzzi, Giacomo G, Colangelo, Salvatore, Prato, Silvia, Moretti, Claudio, D’Amico, Maurizio, Noussan, Patrizia, Garbo, Roberto, Hildick-Smith, David, Gaita, Fiorenzo, and D’Ascenzo, Fabrizio

Abstract

Background: Non-invasive ischaemia tests and biomarkers are widely adopted to rule out acute coronary syndrome in the emergency department. Their diagnostic accuracy has yet to be precisely defined.Methods: Medline, Cochrane Library CENTRAL, EMBASE and Biomed Central were systematically screened (start date 1 September 2016, end date 1 December 2016). Prospective studies (observational or randomised controlled trial) comparing functional/imaging or biochemical tests for patients presenting with chest pain to the emergency department were included.Results: Overall, 77 studies were included, for a total of 49,541 patients (mean age 59.9 years). Fast and six-hour highly sensitive troponin T protocols did not show significant differences in their ability to detect acute coronary syndromes, as they reported a sensitivity and specificity of 0.89 (95% confidence interval 0.79–0.94) and 0.84 (0.74–0.9) vs 0.89 (0.78–0.94) and 0.83 (0.70–0.92), respectively. The addition of copeptin to troponin increased sensitivity and reduced specificity, without improving diagnostic accuracy. The diagnostic value of non-invasive tests for patients without troponin increase was tested. Coronary computed tomography showed the highest level of diagnostic accuracy (sensitivity 0.93 (0.81–0.98) and specificity 0.90 (0.93–0.94)), along with myocardial perfusion scintigraphy (sensitivity 0.85 (0.77–0.91) and specificity 0.92 (0.83–0.96)). Stress echography was inferior to coronary computed tomography but non-inferior to myocardial perfusion scintigraphy, while exercise testing showed the lower level of diagnostic accuracy.Conclusions: Fast and six-hour highly sensitive troponin T protocols provide an overall similar level of diagnostic accuracy to detect acute coronary syndrome. Among the non-invasive ischaemia tests for patients without troponin increase, coronary computed tomography and myocardial perfusion scintigraphy showed the highest sensitivity and specificity.

Published
2019
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138. Planned versus provisional rotational atherectomy for severe calcified coronary lesions: Insights From the ROTATE multi-center registry

Author

Kawamoto, Hiroyoshi, primary, Latib, Azeem, additional, Ruparelia, Neil, additional, Boccuzzi, Giacomo G., additional, Pennacchi, Mauro, additional, Sardella, Gennaro, additional, Garbo, Roberto, additional, Meliga, Emanuele, additional, D'Ascenzo, Fabrizio, additional, Moretti, Claudio, additional, Rossi, Marco Luciano, additional, Presbitero, Patrizia, additional, Ielasi, Alfonso, additional, Magri, Caroline, additional, Nakamura, Sunao, additional, and Colombo, Antonio, additional

Published
2016
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139. Single-Staged Compared With Multi-Staged PCI in Multivessel NSTEMI Patients

Author

Sardella, Gennaro, primary, Lucisano, Luigi, additional, Garbo, Roberto, additional, Pennacchi, Mauro, additional, Cavallo, Erika, additional, Stio, Rocco Edoardo, additional, Calcagno, Simone, additional, Ugo, Fabrizio, additional, Boccuzzi, Giacomo, additional, Fedele, Francesco, additional, and Mancone, Massimo, additional

Published
2016
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140. Impact of Culprit Plaque and Atherothrombotic Components on Incomplete Stent Apposition in Patients With ST-Elevation Myocardial Infarction Treated With Everolimus-Eluting Stents – An OCTAVIA Substudy –

Author

Bernelli, Chiara, primary, Shimamura, Kunihiro, additional, Komukai, Kenichi, additional, Capodanno, Davide, additional, Saia, Francesco, additional, Garbo, Roberto, additional, Burzotta, Francesco, additional, Sirbu, Vasile, additional, Coccato, Micol, additional, Campo, Gianluca, additional, Vignali, Luigi, additional, Yamamoto, Hirosada, additional, Niccoli, Giampaolo, additional, Ladich, Elena, additional, Biondi-Zoccai, Giuseppe, additional, and Guagliumi, Giulio, additional

Published
2016
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141. Retrograde Recanalization of Chronic Total Occlusions in Europe

Author

Galassi, Alfredo R., primary, Sianos, Georgios, additional, Werner, Gerald S., additional, Escaned, Javier, additional, Tomasello, Salvatore D., additional, Boukhris, Marouane, additional, Castaing, Marine, additional, Büttner, Joachim H., additional, Bufe, Alexander, additional, Kalnins, Artis, additional, Spratt, James C., additional, Garbo, Roberto, additional, Hildick-Smith, David, additional, Elhadad, Simon, additional, Gagnor, Andrea, additional, Lauer, Bernward, additional, Bryniarski, Leszek, additional, Christiansen, Evald H., additional, Thuesen, Leif, additional, Meyer-Geßner, Markus, additional, Goktekin, Omer, additional, Carlino, Mauro, additional, Louvard, Yves, additional, Lefèvre, Thierry, additional, Lismanis, Aigars, additional, Gelev, Valery L., additional, Serra, Antonio, additional, Marzà, Francesco, additional, Di Mario, Carlo, additional, and Reifart, Nicolaus, additional

Published
2015
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142. Zotarolimus-Eluting Versus Bare-Metal Stents in Uncertain Drug-Eluting Stent Candidates

Author

Valgimigli, Marco, primary, Patialiakas, Athanasios, additional, Thury, Attila, additional, McFadden, Eugene, additional, Colangelo, Salvatore, additional, Campo, Gianluca, additional, Tebaldi, Matteo, additional, Ungi, Imre, additional, Tondi, Stefano, additional, Roffi, Marco, additional, Menozzi, Alberto, additional, de Cesare, Nicoletta, additional, Garbo, Roberto, additional, Meliga, Emanuele, additional, Testa, Luca, additional, Gabriel, Henrique Mesquita, additional, Airoldi, Flavio, additional, Ferlini, Marco, additional, Liistro, Francesco, additional, Dellavalle, Antonio, additional, Vranckx, Pascal, additional, and Briguori, Carlo, additional

Published
2015
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143. Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry.

Author

Iannaccone, Mario, D'Ascenzo, Fabrizio, Frangieh, Antonio H., Niccoli, Giampaolo, Ugo, Fabrizio, Boccuzzi, Giacomo, Bertaina, Maurizio, Mancone, Massimo, Montefusco, Antonio, Amabile, Nicolas, Sardella, Gennaro, Motreff, Pascal, Toutouzas, Konstantinos, Colombo, Francesco, Garbo, Roberto, Biondi‐Zoccai, Giuseppe, Tamburino, Corrado, Omedè, Pierluigi, Moretti, Claudio, and D'amico, Maurizio

Published
2017
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144. Treatment of the chronic total occlusion: A call to action for the interventional community

Author

Carlino, Mauro, primary, Magri, Caroline J., additional, Uretsky, Barry F., additional, Brilakis, Emmanouil S., additional, Walsh, Simon, additional, Spratt, James C., additional, Hanratty, Colm, additional, Grantham, J. Aaron, additional, Rinfret, Stéphane, additional, Thompson, Craig A., additional, Lombardi, William L., additional, Galassi, Alfredo R., additional, Sianos, George, additional, Latib, Azeem, additional, Garbo, Roberto, additional, Karmpaliotis, Dimitri, additional, Kandzari, David E., additional, and Colombo, Antonio, additional

Published
2014
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145. Second-Generation Drug-Eluting Stent Implantation Followed by 6- Versus 12-Month Dual Antiplatelet Therapy

Author

Colombo, Antonio, primary, Chieffo, Alaide, additional, Frasheri, Arian, additional, Garbo, Roberto, additional, Masotti-Centol, Monica, additional, Salvatella, Neus, additional, Oteo Dominguez, Juan Francisco, additional, Steffanon, Luigi, additional, Tarantini, Giuseppe, additional, Presbitero, Patrizia, additional, Menozzi, Alberto, additional, Pucci, Edoardo, additional, Mauri, Josepa, additional, Cesana, Bruno Mario, additional, Giustino, Gennaro, additional, and Sardella, Gennaro, additional

Published
2014
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146. TCT-190 Percutaneous Coronary Intervention Versus Medical Therapy For Coronary Chronic Total Occlusion: Result From The Italian Registry Of Chronic Total Occlusion (IRCTO)

Author

Tomasello, Salvatore D., primary, Giubilato, Simona, additional, Rubartelli, Paolo, additional, Marzocchi, Antonio, additional, Gagnor, Andrea, additional, Garbo, Roberto, additional, Niccoli, Giampaolo, additional, Tamburino, Corrado, additional, and Galassi, Alfredo R., additional

Published
2014
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147. Mechanisms of Atherothrombosis and Vascular Response to Primary Percutaneous Coronary Intervention in Women Versus Men With Acute Myocardial Infarction

Author

Guagliumi, Giulio, primary, Capodanno, Davide, additional, Saia, Francesco, additional, Musumeci, Giuseppe, additional, Tarantini, Giuseppe, additional, Garbo, Roberto, additional, Tumminello, Gabriele, additional, Sirbu, Vasile, additional, Coccato, Micol, additional, Fineschi, Massimo, additional, Trani, Carlo, additional, De Benedictis, Mauro, additional, Limbruno, Ugo, additional, De Luca, Leonardo, additional, Niccoli, Giampaolo, additional, Bezerra, Hiram, additional, Ladich, Elena, additional, Costa, Marco, additional, Biondi Zoccai, Giuseppe, additional, and Virmani, Renu, additional

Published
2014
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148. Prevalence and outcome of patients with cancer and acute coronary syndrome undergoing percutaneous coronary intervention: a BleeMACS substudy

Author

Iannaccone, Mario, D’Ascenzo, Fabrizio, Vadalà, Paolo, Wilton, Stephen B, Noussan, Patrizia, Colombo, Francesco, Raposeiras Roubín, Sergio, Abu Assi, Emad, González-Juanatey, José Ramón, Simao Henriques, Jose Paulo, Saucedo, Jorge, Kikkert, Wouter J, Nuñez-Gil, Iván, Ariza-Sole, Albert, Song, Xian-tao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Moretti, Claudio, Garbo, Roberto, Huczek, Zenon, Nie, Shao-Ping, Fujii, Toshiharu, Correia, Luis CL, Kawashiri, Masa-aki, García Acuña, José María, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Giordana, Francesca, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Yan, Yan, Fan, Jing-Yao, Ikari, Yuji, Nakahashi, Takuya, Sakata, Kenji, Gaita, Fiorenzo, Yamagishi, Masakazu, Kalpak, Oliver, and Kedev, Sasko

Abstract

Background: The prevalence and outcome of patients with cancer that experience acute coronary syndrome (ACS) have to be determined.Methods and results: The BleeMACS project is a multicentre observational registry enrolling patients with acute coronary syndrome undergoing percutaneous coronary intervention worldwide in 15 hospitals. The primary endpoint was a composite event of death and re-infarction after one year of follow-up. Bleedings were the secondary endpoint. 15,401 patients were enrolled, 926 (6.4%) in the cancer group and 14,475 (93.6%) in the group of patients without cancer. Patients with cancer were older (70.8±10.3 vs. 62.8±12.1 years, P<0.001) with more severe comorbidities and presented more frequently with non-ST-segment elevation myocardial infarction compared with patients without cancer. After one year, patients with cancer more often experienced the composite endpoint (15.2% vs. 5.3%, P<0.001) and bleedings (6.5% vs. 3%, P<0.001). At multiple regression analysis the presence of cancer was the strongest independent predictor for the primary endpoint (hazard ratio (HR) 2.1, 1.8–2.5, P<0.001) and bleedings (HR 1.5, 1.1–2.1, P=0.015). Despite patients with cancer generally being undertreated, beta-blockers (relative risk (RR) 0.6, 0.4–0.9, P=0.05), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (RR 0.5, 0.3–0.8, P=0.02), statins (RR 0.3, 0.2–0.5, P<0.001) and dual antiplatelet therapy (RR 0.5, 0.3–0.9, P=0.05) were shown to be protective factors, while proton pump inhibitors (RR 1, 0.6–1.5, P=0.9) were neutral.Conclusion: Cancer has a non-negligible prevalence in patients with acute coronary syndrome undergoing percutaneous coronary intervention, with a major risk of cardiovascular events and bleedings. Moreover, these patients are often undertreated from clinical despite medical therapy seems to be protective. Registration:The BleeMACS project (NCT02466854).

Published
2018
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