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324,882 results on '"G Yang"'

101. Alloplastic and Implant Materials for Bone Grafting: a Literature Review

Author

U. F. Mukhametov, S. V. Lyulin, D. Y. Borzunov, I. F. Gareev, O. A. Beylerli, and G. Yang

Subjects
костная пластика, имплантационные материалы, дефект, остеокондукция, остеоиндукция, остеогенез, биосовместимые материалы, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Bone reconstruction aft er trauma, infection, tumour or congenital genetic disorder is an important subject of modern medicine usually relying on bone graft ing materials. Autologous bone or autograft is still considered the “gold standard” most eff ective in bone defect reconstruction and osseous regeneration. Having the advantages of autograft ing, a series of issues remain related to a limited donor material, painful graft taking and the risk of putative complications (nonunions, graft rejection, infection, iatrogenic fractures, post-microsurgery arteriovenous shunt thrombosis, etc.). Th erefore, improved biomaterials are demanded to adequately meet the autograft criteria. Choosing optimal graft materials becomes relevant, aside to the rationale of selecting new surgical techniques. Th e osteoconductive and osteoinductive property evaluation in modern osteoplastic materials comprises a research avenue into optimal graft development for osseous correction in maxillofacial surgery, neurosurgery, traumatology and orthopaedics. Such biomaterials can be combined with alloplastic graft s to attain the required properties of osteoconduction, osteoinduction and osteogenesis. Th is analytic literature review focuses on current state-of-the-art in alloplastic graft ing that, in our opinion, grounds the progress of auto- and allograft innovative development.

Published
2021
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102. New Central Nervous System Research from G. Yang and Colleagues Discussed

Subjects
Brain -- Injuries, Neurosciences, Health
Abstract

According to the authors of recent research published in the Journal of Neuroscience, 'Although the palmitoyl acyltransferase (PAT) zinc-finger DHHC containing 17 (zD17) has been implicated in genetic neurological disorders [...]

Published
2011

106. Multiple cooperative systems obtained by powder metallurgy-like processing method: Adenine containing phthalonitrile/graphene/ Fe3O4 high-performance composites with ultra-high EMI shielding

Author

H. Xiao, K. Zeng, J. H. Hu, and G. Yang

Subjects
polymer composites, adenine containing phthalonitrile, electromagnetic interference, heat resistance, uniform dispersion system, Materials of engineering and construction. Mechanics of materials, TA401-492, Chemical technology, TP1-1185
Abstract

Adenine containing phthalonitrile (ADCN)/graphene/Fe3O4 composites with excellent EMI performance, outstanding thermal, thermo-oxidative stability, and heat resistance ae introduced. The interactions between ADCN and nanofillers combined with high-energy ball milling-molding sintering processing method ensure the uniform dispersion of nanofillers in the matrix. The EMI shielding effectiveness (EMI SE) of ADCN/G/Fe3O4 is up to 50 dB with only 0.5 mm thickness, which is one of the best EMI performance compared with previous reports on conductive polymer composites (CPCs). The high-performance ADCN polymer introduces outstanding thermal, thermo-oxidative stability and heat resistance into the composites. The T5% in the air of composites could still maintain more than 491 °C, and the EMI value of composites after flame retardancy test could reach 40 dB. The results prove that ADCN/G/Fe3O4 composite is a promising candidate that could be used in the aerospace industry and under extreme working conditions.

Published
2021
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107. Search for signatures of sterile neutrinos with Double Chooz

Author

T. Abrahão, H. Almazan, J. C. dos Anjos, S. Appel, J. C. Barriere, I. Bekman, T. J. C. Bezerra, L. Bezrukov, E. Blucher, T. Brugière, C. Buck, J. Busenitz, A. Cabrera, M. Cerrada, E. Chauveau, P. Chimenti, O. Corpace, J. V. Dawson, Z. Djurcic, A. Etenko, H. Furuta, I. Gil-Botella, A. Givaudan, H. Gomez, L. F. G. Gonzalez, M. C. Goodman, T. Hara, J. Haser, D. Hellwig, L. Heuermann, A. Hourlier, M. Ishitsuka, J. Jochum, C. Jollet, K. Kale, M. Kaneda, M. Karakac, T. Kawasaki, E. Kemp, H. de Kerret, D. Kryn, M. Kuze, T. Lachenmaier, C. E. Lane, T. Lasserre, C. Lastoria, D. Lhuillier, H. P. Lima Jr, M. Lindner, J. M. López-Casta no, J. M. LoSecco, B. Lubsandorzhiev, J. Maeda, C. Mariani, J. Maricic, J. Martino, T. Matsubara, G. Mention, A. Meregaglia, T. Miletic, R. Milincic, A. Minotti, D. Navas-Nicolás, P. Novella, L. Oberauer, M. Obolensky, A. Onillon, A. Oralbaev, C. Palomares, I. M. Pepe, G. Pronost, J. Reichenbacher, B. Reinhold, S. Schönert, S. Schoppmann, L. Scola, R. Sharankova, V. Sibille, V. Sinev, M. Skorokhvatov, P. Soldin, A. Stahl, I. Stancu, L. F. F. Stokes, F. Suekane, S. Sukhotin, T. Sumiyoshi, Y. Sun, C. Veyssiere, B. Viaud, M. Vivier, S. Wagner, C. Wiebusch, G. Yang, and F. Yermia

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We present a search for signatures of neutrino mixing of electron anti-neutrinos with additional hypothetical sterile neutrino flavors using the Double Chooz experiment. The search is based on data from 5 years of operation of Double Chooz, including 2 years in the two-detector configuration. The analysis is based on a profile likelihood, i.e. comparing the data to the model prediction of disappearance in a data-to-data comparison of the two respective detectors. The analysis is optimized for a model of three active and one sterile neutrino. It is sensitive in the typical mass range $${5 \times 10^{-3}}\,\mathrm{eV}^2 \lesssim \varDelta m^2_{41} \lesssim {3 \times 10^{-1}}\,\mathrm{eV}^2 $$ 5 × 10 - 3 eV 2 ≲ Δ m 41 2 ≲ 3 × 10 - 1 eV 2 for mixing angles down to $$\sin ^2 2\theta _{14} \gtrsim {0.02} $$ sin 2 2 θ 14 ≳ 0.02 . No significant disappearance additionally to the conventional disappearance related to $$\theta _{13} $$ θ 13 is observed and correspondingly exclusion bounds on the sterile mixing parameter $$\theta _{14} $$ θ 14 as a function of $$ \varDelta m^2_{41} $$ Δ m 41 2 are obtained.

Published
2021
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108. Water sharing policies conditioned on hydrologic variability to inform reservoir operations

Author

G. Yang and P. Block

Subjects
Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

Water resources infrastructure is critical for energy and food security; however, the development of large-scale infrastructure, such as hydropower dams, may significantly alter downstream flows, potentially leading to water resources management conflicts and disputes. Mutually agreed upon water sharing policies for the operation of existing or new reservoirs is one of the most effective strategies for mitigating conflict, yet this is a complex task involving the estimation of available water, identification of users and demands, procedures for water sharing, etc. A water sharing policy framework that incorporates reservoir operating rules optimization based on conflicting uses and natural hydrologic variability, specifically tailored to drought conditions, is proposed. First, the trade-off between downstream and upstream water availability utilizing multi-objective optimization of reservoir operating rules is established. Next, reservoir operation with the candidate (optimal) rules is simulated, followed by their performance evaluations, and the rule selections for balancing water uses. Subsequently, a relationship between the reservoir operations simulated from the selected rules and drought-specific conditions is built to derive water sharing policies. Finally, the reservoir operating rules are re-optimized to evaluate the effectiveness of the drought-specific water sharing policies. With a case study of the Grand Ethiopian Renaissance Dam (GERD) on the Blue Nile river, it is demonstrated that the derived water sharing policy can balance GERD power generation and downstream releases, especially in dry conditions, effectively sharing the hydrologic risk in inflow variability among riparian countries. The proposed framework offers a robust approach to inform water sharing policies for sustainable management of water resources.

Published
2021
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110. Characterization of sequence determinants of enhancer function using natural genetic variation

Author

Marty G Yang, Emi Ling, Christopher J Cowley, Michael E Greenberg, and Thomas Vierbuchen

Subjects
gene regulation, transcription factors, enhancers, Medicine, Science, Biology (General), QH301-705.5
Abstract

Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant on enhancer function due to the complexity of DNA sequence motifs that determine transcription factor (TF) binding to enhancers in their native genomic context. Using F1-hybrid cells derived from crosses between distantly related inbred strains of mice, we identified thousands of enhancers with allele-specific TF binding and/or activity. We find that genetic variants located within the central region of enhancers are most likely to alter TF binding and enhancer activity. We observe that the AP-1 family of TFs (Fos/Jun) are frequently required for binding of TEAD TFs and for enhancer function. However, many sequence variants outside of core motifs for AP-1 and TEAD also impact enhancer function, including sequences flanking core TF motifs and AP-1 half sites. Taken together, these data represent one of the most comprehensive assessments of allele-specific TF binding and enhancer function to date and reveal how sequence changes at enhancers alter their function across evolutionary timescales.

Published
2022
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112. Supernova neutrino burst detection with the deep underground neutrino experiment

Author

B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero, F. Azfar, H. Back, J. J. Back, C. Backhouse, P. Baesso, L. Bagby, R. Bajou, S. Balasubramanian, P. Baldi, B. Bambah, F. Barao, G. Barenboim, G. J. Barker, W. Barkhouse, C. Barnes, G. Barr, J. Barranco Monarca, N. Barros, J. L. Barrow, A. Bashyal, V. Basque, F. Bay, J. L. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, D. Belver, N. Benekos, F. Bento Neves, J. Berger, S. Berkman, P. Bernardini, R. M. Berner, H. Berns, S. Bertolucci, M. Betancourt, Y. Bezawada, M. Bhattacharjee, B. Bhuyan, S. Biagi, J. Bian, M. Biassoni, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, B. Blanco Siffert, F. D. M. Blaszczyk, G. C. Blazey, E. Blucher, J. Boissevain, S. Bolognesi, T. Bolton, M. Bonesini, M. Bongrand, F. Bonini, A. Booth, C. Booth, S. Bordoni, A. Borkum, T. Boschi, N. Bostan, P. Bour, S. B. Boyd, D. Boyden, J. Bracinik, D. Braga, D. Brailsford, A. Brandt, J. Bremer, C. Brew, E. Brianne, S. J. Brice, C. Brizzolari, C. Bromberg, G. Brooijmans, J. Brooke, A. Bross, G. Brunetti, N. Buchanan, H. Budd, D. Caiulo, P. Calafiura, J. Calcutt, M. Calin, S. Calvez, E. Calvo, L. Camilleri, A. Caminata, M. Campanelli, D. Caratelli, G. Carini, B. Carlus, P. Carniti, I. Caro Terrazas, H. Carranza, A. Castillo, C. Castromonte, C. Cattadori, F. Cavalier, F. Cavanna, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, M. Chalifour, C. Chang, E. Chardonnet, A. Chatterjee, S. Chattopadhyay, J. Chaves, H. Chen, M. Chen, Y. Chen, D. Cherdack, C. Chi, S. Childress, A. Chiriacescu, K. Cho, S. Choubey, A. Christensen, D. Christian, G. Christodoulou, E. Church, P. Clarke, T. E. Coan, A. G. Cocco, J. A. B. Coelho, E. Conley, J. M. Conrad, M. Convery, L. Corwin, P. Cotte, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, E. Cristaldo, R. Cross, C. Cuesta, Y. Cui, D. Cussans, M. Dabrowski, H. da Motta, L. Da Silva Peres, C. David, Q. David, G. S. Davies, S. Davini, J. Dawson, K. De, R. M. De Almeida, P. Debbins, I. De Bonis, M. P. Decowski, A. de Gouvêa, P. C. De Holanda, I. L. De Icaza Astiz, A. Deisting, P. De Jong, A. Delbart, D. Delepine, M. Delgado, A. Dell-Acqua, P. De Lurgio, J. R. T. de Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, G. Deptuch, A. De Roeck, V. De Romeri, J. J. De Vries, R. Dharmapalan, M. Dias, F. Diaz, J. S. Díaz, S. Di Domizio, L. Di Giulio, P. Ding, L. Di Noto, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, N. Dokania, M. J. Dolinski, L. Domine, D. Douglas, F. Drielsma, D. Duchesneau, K. Duffy, P. Dunne, T. Durkin, H. Duyang, O. Dvornikov, D. A. Dwyer, A. S. Dyshkant, M. Eads, D. Edmunds, J. Eisch, S. Emery, A. Ereditato, C. O. Escobar, L. Escudero Sanchez, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, A. Falcone, C. Farnese, Y. Farzan, J. Felix, E. Fernandez-Martinez, P. Fernandez Menendez, F. Ferraro, L. Fields, A. Filkins, F. Filthaut, R. S. Fitzpatrick, W. Flanagan, B. Fleming, R. Flight, J. Fowler, W. Fox, J. Franc, K. Francis, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, S. Fuess, I. Furic, A. P. Furmanski, A. Gago, H. Gallagher, A. Gallego-Ros, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, R. Gandhi, R. Gandrajula, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, S. Gardiner, D. Gastler, G. Ge, B. Gelli, A. Gendotti, S. Gent, Z. Ghorbani-Moghaddam, D. Gibin, I. Gil-Botella, C. Girerd, A. K. Giri, D. Gnani, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. V. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, J. A. Gonzalez-Cuevas, M. C. Goodman, O. Goodwin, S. Goswami, C. Gotti, E. Goudzovski, C. Grace, M. Graham, E. Gramellini, R. Gran, E. Granados, A. Grant, C. Grant, D. Gratieri, P. Green, S. Green, L. Greenler, M. Greenwood, J. Greer, W. C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, W. Gu, V. Guarino, R. Guenette, A. Guglielmi, B. Guo, K. K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, S. Gwon, A. Habig, A. Hackenburg, H. Hadavand, R. Haenni, A. Hahn, J. Haigh, J. Haiston, T. Hamernik, P. Hamilton, J. Han, K. Harder, D. A. Harris, J. Hartnell, T. Hasegawa, R. Hatcher, E. Hazen, A. Heavey, K. M. Heeger, J. Heise, K. Hennessy, S. Henry, M. A. Hernandez Morquecho, K. Herner, L. Hertel, A. S. Hesam, J. Hewes, A. Higuera, T. Hill, S. J. Hillier, A. Himmel, J. Hoff, C. Hohl, A. Holin, E. Hoppe, G. A. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Huang, J. Hugon, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, A. Ioannisian, R. Itay, A. Izmaylov, E. James, B. Jargowsky, F. Jediny, C. Jesùs-Valls, X. Ji, L. Jiang, S. Jiménez, A. Jipa, A. Joglekar, C. Johnson, R. Johnson, B. Jones, S. Jones, C. K. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. Kaboth, I. Kadenko, F. Kamiya, G. Karagiorgi, A. Karcher, M. Karolak, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, N. Kazaryan, E. Kearns, P. Keener, K. J. Kelly, E. Kemp, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, A. Khvedelidze, D. Kim, B. King, B. Kirby, M. Kirby, J. Klein, K. Koehler, L. W. Koerner, S. Kohn, P. P. Koller, M. Kordosky, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, F. Krennrich, I. Kreslo, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, R. Kumar, C. Kuruppu, V. Kus, T. Kutter, A. Lambert, K. Lande, C. E. Lane, K. Lang, T. Langford, P. Lasorak, D. Last, C. Lastoria, A. Laundrie, A. Lawrence, I. Lazanu, R. LaZur, T. Le, J. Learned, P. LeBrun, G. Lehmann Miotto, R. Lehnert, M. A. Leigui de Oliveira, M. Leitner, M. Leyton, L. Li, S. Li, S. W. Li, T. Li, Y. Li, H. Liao, C. S. Lin, S. Lin, A. Lister, B. R. Littlejohn, J. Liu, S. Lockwitz, T. Loew, M. Lokajicek, I. Lomidze, K. Long, K. Loo, D. Lorca, T. Lord, J. M. LoSecco, W. C. Louis, K. B. Luk, X. Luo, N. Lurkin, T. Lux, V. P. Luzio, D. MacFarland, A. A. Machado, P. Machado, C. T. Macias, J. R. Macier, A. Maddalena, P. Madigan, S. Magill, K. Mahn, A. Maio, A. Major, J. A. Maloney, G. Mandrioli, J. Maneira, L. Manenti, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, N. Martinez, D. A. Martinez Caicedo, S. Martynenko, K. Mason, A. Mastbaum, M. Masud, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, R. Mazza, A. Mazzacane, E. Mazzucato, E. McCluskey, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, A. Mefodiev, P. Mehta, P. Melas, M. Mellinato, O. Mena, S. Menary, H. Mendez, A. Menegolli, G. Meng, M. D. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, G. Michna, T. Miedema, J. Migenda, R. Milincic, W. Miller, J. Mills, C. Milne, O. Mineev, O. G. Miranda, S. Miryala, C. S. Mishra, S. R. Mishra, A. Mislivec, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. Molina, L. Molina Bueno, A. Montanari, C. Montanari, D. Montanari, L. M. Montano Zetina, J. Moon, M. Mooney, A. Moor, D. Moreno, B. Morgan, C. Morris, C. Mossey, E. Motuk, C. A. Moura, J. Mousseau, W. Mu, L. Mualem, J. Mueller, M. Muether, S. Mufson, F. Muheim, A. Muir, M. Mulhearn, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, S. Nagu, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, D. Navas-Nicolás, N. Nayak, M. Nebot-Guinot, L. Necib, K. Negishi, J. K. Nelson, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, D. Newhart, R. Nichol, E. Niner, K. Nishimura, A. Norman, A. Norrick, R. Northrop, P. Novella, J. A. Nowak, M. Oberling, A. Olivares Del Campo, A. Olivier, Y. Onel, Y. Onishchuk, J. Ott, L. Pagani, S. Pakvasa, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, S. Paramesvaran, S. Parke, Z. Parsa, M. Parvu, S. Pascoli, L. Pasqualini, J. Pasternak, J. Pater, C. Patrick, L. Patrizii, R. B. Patterson, S. J. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, S. J. M. Peeters, Y. Penichot, E. Pennacchio, A. Penzo, O. L. G. Peres, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, F. Piastra, L. Pickering, F. Pietropaolo, J. Pillow, J. Pinzino, R. Plunkett, R. Poling, X. Pons, N. Poonthottathil, S. Pordes, M. Potekhin, R. Potenza, B. V. K. S. Potukuchi, J. Pozimski, M. Pozzato, S. Prakash, T. Prakash, S. Prince, G. Prior, D. Pugnere, K. Qi, X. Qian, J. L. Raaf, R. Raboanary, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, M. Rajaoalisoa, I. Rakhno, H. T. Rakotondramanana, L. Rakotondravohitra, Y. A. Ramachers, R. Rameika, M. A. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, S. Ravat, H. Razafinime, J. S. Real, B. Rebel, D. Redondo, M. Reggiani-Guzzo, T. Rehak, J. Reichenbacher, S. D. Reitzner, A. Renshaw, S. Rescia, F. Resnati, A. Reynolds, G. Riccobene, L. C. J. Rice, K. Rielage, Y. Rigaut, D. Rivera, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, J. Rodriguez Rondon, A. J. Roeth, H. Rogers, S. Rosauro-Alcaraz, M. Rossella, J. Rout, S. Roy, A. Rubbia, C. Rubbia, B. Russell, J. Russell, D. Ruterbories, R. Saakyan, S. Sacerdoti, T. Safford, N. Sahu, P. Sala, N. Samios, M. C. Sanchez, D. A. Sanders, D. Sankey, S. Santana, M. Santos-Maldonado, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, V. Savinov, A. Scaramelli, A. Scarff, A. Scarpelli, T. Schaffer, H. Schellman, P. Schlabach, D. Schmitz, K. Scholberg, A. Schukraft, E. Segreto, J. Sensenig, I. Seong, A. Sergi, F. Sergiampietri, D. Sgalaberna, M. H. Shaevitz, S. Shafaq, M. Shamma, H. R. Sharma, R. Sharma, T. Shaw, C. Shepherd-Themistocleous, S. Shin, D. Shooltz, R. Shrock, L. Simard, N. Simos, J. Sinclair, G. Sinev, J. Singh, V. Singh, R. Sipos, F. W. Sippach, G. Sirri, A. Sitraka, K. Siyeon, D. Smargianaki, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, P. Snopok, M. Soares Nunes, H. Sobel, M. Soderberg, C. J. Solano Salinas, S. Söldner-Rembold, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, J. Soto-Oton, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, K. Spurgeon, R. Staley, M. Stancari, L. Stanco, H. M. Steiner, J. Stewart, B. Stillwell, J. Stock, F. Stocker, T. Stokes, M. Strait, T. Strauss, S. Striganov, A. Stuart, D. Summers, A. Surdo, V. Susic, L. Suter, C. M. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, R. Talaga, H. A. Tanaka, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tatar, R. Tayloe, A. M. Teklu, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, A. Thea, J. L. Thompson, C. Thorn, S. C. Timm, A. Tonazzo, M. Torti, M. Tórtola, F. Tortorici, D. Totani, M. Toups, C. Touramanis, J. Trevor, W. H. Trzaska, Y. T. Tsai, Z. Tsamalaidze, K. V. Tsang, N. Tsverava, S. Tufanli, C. Tull, E. Tyley, M. Tzanov, M. A. Uchida, J. Urheim, T. Usher, M. R. Vagins, P. Vahle, G. A. Valdiviesso, E. Valencia, Z. Vallari, J. W. F. Valle, S. Vallecorsa, R. Van Berg, R. G. Van de Water, D. Vanegas Forero, F. Varanini, D. Vargas, G. Varner, J. Vasel, G. Vasseur, K. Vaziri, S. Ventura, A. Verdugo, S. Vergani, M. A. Vermeulen, M. Verzocchi, H. Vieira de Souza, C. Vignoli, C. Vilela, B. Viren, T. Vrba, T. Wachala, A. V. Waldron, M. Wallbank, H. Wang, J. Wang, Y. Wang, K. Warburton, D. Warner, M. Wascko, D. Waters, A. Watson, P. Weatherly, A. Weber, M. Weber, H. Wei, A. Weinstein, D. Wenman, M. Wetstein, M. R. While, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, C. Wilkinson, Z. Williams, F. Wilson, R. J. Wilson, J. Wolcott, T. Wongjirad, K. Wood, L. Wood, E. Worcester, M. Worcester, C. Wret, W. Wu, Y. Xiao, G. Yang, T. Yang, N. Yershov, K. Yonehara, T. Young, B. Yu, J. Yu, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, L. Zazueta, G. P. Zeller, J. Zennamo, K. Zeug, C. Zhang, M. Zhao, E. Zhivun, G. Zhu, E. D. Zimmerman, M. Zito, S. Zucchelli, J. Zuklin, V. Zutshi, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the $$\nu _e$$ ν e spectral parameters of the neutrino burst will be considered.

Published
2021
Full Text
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113. Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment

Author

B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero, F. Azfar, H. Back, J. J. Back, C. Backhouse, P. Baesso, L. Bagby, R. Bajou, S. Balasubramanian, P. Baldi, B. Bambah, F. Barao, G. Barenboim, G. J. Barker, W. Barkhouse, C. Barnes, G. Barr, J. Barranco Monarca, N. Barros, J. L. Barrow, A. Bashyal, V. Basque, F. Bay, J. L. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, D. Belver, N. Benekos, F. Bento Neves, J. Berger, S. Berkman, P. Bernardini, R. M. Berner, H. Berns, S. Bertolucci, M. Betancourt, Y. Bezawada, M. Bhattacharjee, B. Bhuyan, S. Biagi, J. Bian, M. Biassoni, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, B. Blanco Siffert, F. D. M. Blaszczyk, G. C. Blazey, E. Blucher, J. Boissevain, S. Bolognesi, T. Bolton, M. Bonesini, M. Bongrand, F. Bonini, A. Booth, C. Booth, S. Bordoni, A. Borkum, T. Boschi, N. Bostan, P. Bour, S. B. Boyd, D. Boyden, J. Bracinik, D. Braga, D. Brailsford, A. Brandt, J. Bremer, C. Brew, E. Brianne, S. J. Brice, C. Brizzolari, C. Bromberg, G. Brooijmans, J. Brooke, A. Bross, G. Brunetti, N. Buchanan, H. Budd, D. Caiulo, P. Calafiura, J. Calcutt, M. Calin, S. Calvez, E. Calvo, L. Camilleri, A. Caminata, M. Campanelli, D. Caratelli, G. Carini, B. Carlus, P. Carniti, I. Caro Terrazas, H. Carranza, A. Castillo, C. Castromonte, C. Cattadori, F. Cavalier, F. Cavanna, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, M. Chalifour, C. Chang, E. Chardonnet, A. Chatterjee, S. Chattopadhyay, J. Chaves, H. Chen, M. Chen, Y. Chen, D. Cherdack, C. Chi, S. Childress, A. Chiriacescu, K. Cho, S. Choubey, A. Christensen, D. Christian, G. Christodoulou, E. Church, P. Clarke, T. E. Coan, A. G. Cocco, J. A. B. Coelho, E. Conley, J. M. Conrad, M. Convery, L. Corwin, P. Cotte, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, E. Cristaldo, R. Cross, C. Cuesta, Y. Cui, D. Cussans, M. Dabrowski, H. da Motta, L. Da Silva Peres, C. David, Q. David, G. S. Davies, S. Davini, J. Dawson, K. De, R. M. De Almeida, P. Debbins, I. De Bonis, M. P. Decowski, A. de Gouvêa, P. C. De Holanda, I. L. De Icaza Astiz, A. Deisting, P. De Jong, A. Delbart, D. Delepine, M. Delgado, A. Dell’Acqua, P. De Lurgio, J. R. T. de Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, G. Deptuch, A. De Roeck, V. De Romeri, J. J. De Vries, R. Dharmapalan, M. Dias, F. Diaz, J. S. Díaz, S. Di Domizio, L. Di Giulio, P. Ding, L. Di Noto, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, N. Dokania, M. J. Dolinski, L. Domine, D. Douglas, F. Drielsma, D. Duchesneau, K. Duffy, P. Dunne, T. Durkin, H. Duyang, O. Dvornikov, D. A. Dwyer, A. S. Dyshkant, M. Eads, D. Edmunds, J. Eisch, S. Emery, A. Ereditato, C. O. Escobar, L. Escudero Sanchez, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, A. Falcone, C. Farnese, Y. Farzan, J. Felix, E. Fernandez-Martinez, P. Fernandez Menendez, F. Ferraro, L. Fields, A. Filkins, F. Filthaut, R. S. Fitzpatrick, W. Flanagan, B. Fleming, R. Flight, J. Fowler, W. Fox, J. Franc, K. Francis, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, S. Fuess, I. Furic, A. P. Furmanski, A. Gago, H. Gallagher, A. Gallego-Ros, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, R. Gandhi, R. Gandrajula, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, S. Gardiner, D. Gastler, G. Ge, B. Gelli, A. Gendotti, S. Gent, Z. Ghorbani-Moghaddam, D. Gibin, I. Gil-Botella, C. Girerd, A. K. Giri, D. Gnani, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. V. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, J. A. Gonzalez-Cuevas, M. C. Goodman, O. Goodwin, S. Goswami, C. Gotti, E. Goudzovski, C. Grace, M. Graham, E. Gramellini, R. Gran, E. Granados, A. Grant, C. Grant, D. Gratieri, P. Green, S. Green, L. Greenler, M. Greenwood, J. Greer, W. C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, W. Gu, V. Guarino, R. Guenette, A. Guglielmi, B. Guo, K. K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, S. Gwon, A. Habig, A. Hackenburg, H. Hadavand, R. Haenni, A. Hahn, J. Haigh, J. Haiston, T. Hamernik, P. Hamilton, J. Han, K. Harder, D. A. Harris, J. Hartnell, T. Hasegawa, R. Hatcher, E. Hazen, A. Heavey, K. M. Heeger, J. Heise, K. Hennessy, S. Henry, M. A. Hernandez Morquecho, K. Herner, L. Hertel, A. S. Hesam, J. Hewes, A. Higuera, T. Hill, S. J. Hillier, A. Himmel, J. Hoff, C. Hohl, A. Holin, E. Hoppe, G. A. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Huang, J. Hugon, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, A. Ioannisian, R. Itay, A. Izmaylov, E. James, B. Jargowsky, F. Jediny, C. Jesùs-Valls, X. Ji, L. Jiang, S. Jiménez, A. Jipa, A. Joglekar, C. Johnson, R. Johnson, B. Jones, S. Jones, C. K. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. Kaboth, I. Kadenko, F. Kamiya, G. Karagiorgi, A. Karcher, M. Karolak, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, N. Kazaryan, E. Kearns, P. Keener, K. J. Kelly, E. Kemp, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, A. Khvedelidze, D. Kim, B. King, B. Kirby, M. Kirby, J. Klein, K. Koehler, L. W. Koerner, S. Kohn, P. P. Koller, M. Kordosky, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, F. Krennrich, I. Kreslo, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, R. Kumar, C. Kuruppu, V. Kus, T. Kutter, A. Lambert, K. Lande, C. E. Lane, K. Lang, T. Langford, P. Lasorak, D. Last, C. Lastoria, A. Laundrie, A. Lawrence, I. Lazanu, R. LaZur, T. Le, J. Learned, P. LeBrun, G. Lehmann Miotto, R. Lehnert, M. A. Leigui de Oliveira, M. Leitner, M. Leyton, L. Li, S. Li, S. W. Li, T. Li, Y. Li, H. Liao, C. S. Lin, S. Lin, A. Lister, B. R. Littlejohn, J. Liu, S. Lockwitz, T. Loew, M. Lokajicek, I. Lomidze, K. Long, K. Loo, D. Lorca, T. Lord, J. M. LoSecco, W. C. Louis, K. B. Luk, X. Luo, N. Lurkin, T. Lux, V. P. Luzio, D. MacFarland, A. A. Machado, P. Machado, C. T. Macias, J. R. Macier, A. Maddalena, P. Madigan, S. Magill, K. Mahn, A. Maio, J. A. Maloney, G. Mandrioli, J. Maneira, L. Manenti, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, N. Martinez, D. A. Martinez Caicedo, S. Martynenko, K. Mason, A. Mastbaum, M. Masud, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, R. Mazza, A. Mazzacane, E. Mazzucato, E. McCluskey, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, A. Mefodiev, P. Mehta, P. Melas, M. Mellinato, O. Mena, S. Menary, H. Mendez, A. Menegolli, G. Meng, M. D. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, G. Michna, T. Miedema, J. Migenda, R. Milincic, W. Miller, J. Mills, C. Milne, O. Mineev, O. G. Miranda, S. Miryala, C. S. Mishra, S. R. Mishra, A. Mislivec, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. Molina, L. Molina Bueno, A. Montanari, C. Montanari, D. Montanari, L. M. Montano Zetina, J. Moon, M. Mooney, A. Moor, D. Moreno, B. Morgan, C. Morris, C. Mossey, E. Motuk, C. A. Moura, J. Mousseau, W. Mu, L. Mualem, J. Mueller, M. Muether, S. Mufson, F. Muheim, A. Muir, M. Mulhearn, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, S. Nagu, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, D. Navas-Nicolás, N. Nayak, M. Nebot-Guinot, L. Necib, K. Negishi, J. K. Nelson, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, D. Newhart, R. Nichol, E. Niner, K. Nishimura, A. Norman, A. Norrick, R. Northrop, P. Novella, J. A. Nowak, M. Oberling, A. Olivares Del Campo, A. Olivier, Y. Onel, Y. Onishchuk, J. Ott, L. Pagani, S. Pakvasa, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, S. Paramesvaran, J. C. Park, S. Parke, Z. Parsa, M. Parvu, S. Pascoli, L. Pasqualini, J. Pasternak, J. Pater, C. Patrick, L. Patrizii, R. B. Patterson, S. J. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, S. J. M. Peeters, Y. Penichot, E. Pennacchio, A. Penzo, O. L. G. Peres, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, F. Piastra, L. Pickering, F. Pietropaolo, J. Pillow, J. Pinzino, R. Plunkett, R. Poling, X. Pons, N. Poonthottathil, S. Pordes, M. Potekhin, R. Potenza, B. V. K. S. Potukuchi, J. Pozimski, M. Pozzato, S. Prakash, T. Prakash, S. Prince, G. Prior, D. Pugnere, K. Qi, X. Qian, J. L. Raaf, R. Raboanary, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, M. Rajaoalisoa, I. Rakhno, H. T. Rakotondramanana, L. Rakotondravohitra, Y. A. Ramachers, R. Rameika, M. A. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, S. Ravat, H. Razafinime, J. S. Real, B. Rebel, D. Redondo, M. Reggiani-Guzzo, T. Rehak, J. Reichenbacher, S. D. Reitzner, A. Renshaw, S. Rescia, F. Resnati, A. Reynolds, G. Riccobene, L. C. J. Rice, K. Rielage, Y. Rigaut, D. Rivera, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, J. Rodriguez Rondon, A. J. Roeth, H. Rogers, S. Rosauro-Alcaraz, M. Rossella, J. Rout, S. Roy, A. Rubbia, C. Rubbia, B. Russell, J. Russell, D. Ruterbories, R. Saakyan, S. Sacerdoti, T. Safford, N. Sahu, P. Sala, N. Samios, M. C. Sanchez, D. A. Sanders, D. Sankey, S. Santana, M. Santos-Maldonado, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, V. Savinov, A. Scaramelli, A. Scarff, A. Scarpelli, T. Schaffer, H. Schellman, P. Schlabach, D. Schmitz, K. Scholberg, A. Schukraft, E. Segreto, J. Sensenig, I. Seong, A. Sergi, F. Sergiampietri, D. Sgalaberna, M. H. Shaevitz, S. Shafaq, M. Shamma, H. R. Sharma, R. Sharma, T. Shaw, C. Shepherd-Themistocleous, S. Shin, D. Shooltz, R. Shrock, L. Simard, N. Simos, J. Sinclair, G. Sinev, J. Singh, V. Singh, R. Sipos, F. W. Sippach, G. Sirri, A. Sitraka, K. Siyeon, D. Smargianaki, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, P. Snopok, M. Soares Nunes, H. Sobel, M. Soderberg, C. J. Solano Salinas, S. Söldner-Rembold, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, J. Soto-Oton, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, K. Spurgeon, R. Staley, M. Stancari, L. Stanco, H. M. Steiner, J. Stewart, B. Stillwell, J. Stock, F. Stocker, D. Stocks, T. Stokes, M. Strait, T. Strauss, S. Striganov, A. Stuart, D. Summers, A. Surdo, V. Susic, L. Suter, C. M. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, R. Talaga, H. A. Tanaka, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tatar, R. Tayloe, A. M. Teklu, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, A. Thea, J. L. Thompson, C. Thorn, S. C. Timm, J. Todd, A. Tonazzo, M. Torti, M. Tortola, F. Tortorici, D. Totani, M. Toups, C. Touramanis, J. Trevor, W. H. Trzaska, Y.-T. Tsai, Z. Tsamalaidze, K. V. Tsang, N. Tsverava, S. Tufanli, C. Tull, E. Tyley, M. Tzanov, M. A. Uchida, J. Urheim, T. Usher, M. R. Vagins, P. Vahle, G. A. Valdiviesso, E. Valencia, Z. Vallari, J. W. F. Valle, S. Vallecorsa, R. Van Berg, R. G. Van de Water, D. Vanegas Forero, F. Varanini, D. Vargas, G. Varner, J. Vasel, G. Vasseur, K. Vaziri, S. Ventura, A. Verdugo, S. Vergani, M. A. Vermeulen, M. Verzocchi, H. Vieira de Souza, C. Vignoli, C. Vilela, B. Viren, T. Vrba, T. Wachala, A. V. Waldron, M. Wallbank, H. Wang, J. Wang, Y. Wang, K. Warburton, D. Warner, M. Wascko, D. Waters, A. Watson, P. Weatherly, A. Weber, M. Weber, H. Wei, A. Weinstein, D. Wenman, M. Wetstein, M. R. While, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, C. Wilkinson, Z. Williams, F. Wilson, R. J. Wilson, J. Wolcott, T. Wongjirad, K. Wood, L. Wood, E. Worcester, M. Worcester, C. Wret, W. Wu, Y. Xiao, G. Yang, T. Yang, N. Yershov, K. Yonehara, T. Young, B. Yu, J. Yu, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, L. Zazueta, G. P. Zeller, J. Zennamo, K. Zeug, C. Zhang, M. Zhao, Y. Zhao, E. Zhivun, G. Zhu, E. D. Zimmerman, M. Zito, S. Zucchelli, J. Zuklin, V. Zutshi, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.

Published
2021
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115. Reactor rate modulation oscillation analysis with two detectors in Double Chooz

Author

The Double Chooz collaboration, T. Abrahão, H. Almazan, J. C. dos Anjos, S. Appel, J. C. Barriere, I. Bekman, T. J. C. Bezerra, L. Bezrukov, E. Blucher, T. Brugière, C. Buck, J. Busenitz, A. Cabrera, M. Cerrada, E. Chauveau, P. Chimenti, O. Corpace, J. V. Dawson, Z. Djurcic, A. Etenko, H. Furuta, I. Gil-Botella, A. Givaudan, H. Gomez, L. F. G. Gonzalez, M. C. Goodman, T. Hara, J. Haser, D. Hellwig, A. Hourlier, M. Ishitsuka, J. Jochum, C. Jollet, K. Kale, M. Kaneda, M. Karakac, T. Kawasaki, E. Kemp, H. de Kerret, D. Kryn, M. Kuze, T. Lachenmaier, C. E. Lane, T. Lasserre, C. Lastoria, D. Lhuillier, H. P. Lima, M. Lindner, J. M. López-Castaño, J. M. LoSecco, B. Lubsandorzhiev, J. Maeda, C. Mariani, J. Maricic, J. Martino, T. Matsubara, G. Mention, A. Meregaglia, T. Miletic, R. Milincic, A. Minotti, D. Navas-Nicolás, P. Novella, L. Oberauer, M. Obolensky, A. Onillon, A. Oralbaev, C. Palomares, I. M. Pepe, G. Pronost, J. Reichenbacher, B. Reinhold, S. Schönert, S. Schoppmann, L. Scola, R. Sharankova, V. Sibille, V. Sinev, M. Skorokhvatov, P. Soldin, A. Stahl, I. Stancu, L. F. F. Stokes, F. Suekane, S. Sukhotin, T. Sumiyoshi, Y. Sun, C. Veyssiere, B. Viaud, M. Vivier, S. Wagner, C. Wiebusch, G. Yang, and F. Yermia

Subjects
Neutrino Detectors and Telescopes (experiments), Oscillation, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A θ 13 oscillation analysis based on the observed antineutrino rates at the Double Chooz far and near detectors for different reactor power conditions is presented. This approach provides a so far unique simultaneous determination of θ 13 and the total background rates without relying on any assumptions on the specific background contributions. The analysis comprises 865 days of data collected in both detectors with at least one reactor in operation. The oscillation results are enhanced by the use of 24.06 days (12.74 days) of reactor-off data in the far (near) detector. The analysis considers the ν ¯ e $$ {\overline{\nu}}_e $$ interactions up to a visible energy of 8.5 MeV, using the events at higher energies to build a cosmogenic background model considering fast-neutrons interactions and 9Li decays. The background-model-independent determination of the mixing angle yields sin2(2θ 13) = 0.094 ± 0.017, being the best-fit total background rates fully consistent with the cosmogenic background model. A second oscillation analysis is also performed constraining the total background rates to the cosmogenic background estimates. While the central value is not significantly modified due to the consistency between the reactor-off data and the background estimates, the addition of the background model reduces the uncertainty on θ 13 to 0.015. Along with the oscillation results, the normalization of the anti-neutrino rate is measured with a precision of 0.86%, reducing the 1.43% uncertainty associated to the expectation.

Published
2021
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116. New Biomechanics Study Findings Recently Were Reported by G. Yang and Co-Researchers (Measurement of deformation rate in nasal septum deviation by three-dimensional computer tomography reconstruction and its application in nasal septoplasty ...)

Subjects
Biomechanics -- Measurement, Rhinoplasty -- Measurement, Computers, News, opinion and commentary
Abstract

2017 AUG 23 (VerticalNews) -- By a News Reporter-Staff News Editor at Computer Weekly News -- Data detailed on Biomechanics have been presented. According to news reporting originating from Guangdong, [...]

Published
2017

117. Solvent-free synthesis of oleic acid-based wax esters using recyclable acidic deep eutectic solvent

Author

Z. Li, W. Liu, and G. Yang

Subjects
Liquid wax esters, Esterification, Deep eutectic solvents, Solvent-free, p-toluenesulfonic acid, Nutrition. Foods and food supply, TX341-641
Abstract

Wax esters have been widely used in cosmetics and pharmaceutical products. Oleic acid wax esters can be used to replace spermaceti oil or jojoba oil. In this work, the acidic deep eutectic solvent (DES) composed of choline chloride and p-toluenesulfonic acid (1:4, mol/mol) was used as an efficient recyclable catalyst for the synthesis of oleic acid-based liquid wax esters through an esterification reaction. The esterification conversion of cetyl alcohol reached 99.1% under the following optimal reaction conditions: 5% DES as catalyst, molar ratio of fatty acid to alcohol of 1.3:1 and reaction temperature of 70 oC for 3h. The catalyst recovery experiments showed that this low-price acidic DES catalyst could be reused five times with uniform activity. Moreover, DES-catalyzed solvent-free esterification could be applied in the preparation of other oleic acid-based wax esters and excellent conversions (> 96%) could be obtained under such mild conditions.

Published
2022
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118. Inhibition of a C-rich oligodeoxynucleotide on activation of immune cells in vitro and enhancement of antibody response in mice G. Yang et al. An inhibitory ODN on immune activation.

Author

Guang Yang, Min Wan, Yongsheng Zhang, Luguo Sun, Ran Sun, Dali Hu, Xiaojing Zhou, Li Wang, Xiuli Wu, Liying Wang, and Yongli Yu

Subjects
*MITOCHONDRIAL DNA, *INFLUENZA viruses, *HERPESVIRUS diseases, *HERPESVIRUSES, *THERAPEUTICS
Abstract

To explore the possibility that human mitochondrial genomic DNA-mimicking oligodeoxynucleotides could regulate the immune response, a series of mitochondrial DNA-based oligodeoxynucleotides (MTODNs) were designed and studied to determine their immunoregulatory effects on immune cells activated by toll-like receptor (TLR) stimulation. The results showed that a C-rich MTODN, designated MT01, was able to inhibit the proliferation of human peripheral blood mononuclear cells (PBMCs) induced by cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) and the production of type I interferon (IFN) from human PBMCs stimulated by TLR agonists, including inactivated influenza virus, imiquimod, inactivated herpes simplex virus-1 (HSV-1) and CpG ODNs. In addition, MT01 inhibited the CpG ODN-enhanced antibody response and this inhibition could be related to the antagonism of TLR9-activation pathways in B cells. Notably, unlike the G-rich suppressive ODNs reported, MT01 is composed of ACCCCCTCT repeats. These data imply that MT01 represents a novel class of immunosuppressive ODNs that could be candidate biologicals with therapeutic use in TLR activation-associated diseases. [ABSTRACT FROM AUTHOR]

Published
2010
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119. Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280

Author

The T2K collaboration, K. Abe, N. Akhlaq, R. Akutsu, A. Ali, C. Alt, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, T. Arihara, Y. Asada, Y. Ashida, E. T. Atkin, Y. Awataguchi, S. Ban, M. Barbi, G. J. Barker, G. Barr, D. Barrow, C. Barry, M. Batkiewicz-Kwasniak, A. Beloshapkin, F. Bench, V. Berardi, L. Berns, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, T. Bonus, B. Bourguille, S. B. Boyd, D. Brailsford, A. Bravar, D. Bravo Berguño, C. Bronner, S. Bron, A. Bubak, M. Buizza Avanzini, J. Calcutt, T. Campbell, S. Cao, S. L. Cartwright, M. G. Catanesi, A. Cervera, A. Chappell, C. Checchia, D. Cherdack, N. Chikuma, G. Christodoulou, M. Cicerchia, J. Coleman, G. Collazuol, L. Cook, D. Coplowe, A. Cudd, A. Dabrowska, G. De Rosa, T. Dealtry, P. F. Denner, S. R. Dennis, C. Densham, F. Di Lodovico, N. Dokania, S. Dolan, T. A. Doyle, O. Drapier, J. Dumarchez, P. Dunne, A. Eguchi, L. Eklund, S. Emery-Schrenk, A. Ereditato, P. Fernandez, T. Feusels, A. J. Finch, G. A. Fiorentini, G. Fiorillo, C. Francois, M. Friend, Y. Fujii, R. Fujita, D. Fukuda, R. Fukuda, Y. Fukuda, K. Fusshoeller, C. Giganti, T. Golan, M. Gonin, A. Gorin, M. Guigue, D. R. Hadley, J. T. Haigh, P. Hamacher-Baumann, M. Hartz, T. Hasegawa, S. Hassani, N. C. Hastings, T. Hayashino, Y. Hayato, A. Hiramoto, M. Hogan, J. Holeczek, N. T. Hong Van, T. Honjo, F. Iacob, A. K. Ichikawa, M. Ikeda, T. Ishida, T. Ishii, M. Ishitsuka, K. Iwamoto, A. Izmaylov, N. Izumi, M. Jakkapu, B. Jamieson, S. J. Jenkins, C. Jesús-Valls, M. Jiang, S. Johnson, P. Jonsson, C. K. Jung, X. Junjie, P. B. Jurj, M. Kabirnezhad, A. C. Kaboth, T. Kajita, H. Kakuno, J. Kameda, D. Karlen, S. P. Kasetti, Y. Kataoka, Y. Katayama, T. Katori, Y. Kato, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, H. Kikutani, H. Kim, S. King, J. Kisiel, A. Knight, A. Knox, T. Kobata, T. Kobayashi, L. Koch, T. Koga, A. Konaka, L. L. Kormos, Y. Koshio, A. Kostin, K. Kowalik, H. Kubo, Y. Kudenko, N. Kukita, S. Kuribayashi, R. Kurjata, T. Kutter, M. Kuze, L. Labarga, J. Lagoda, M. Lamoureux, D. Last, M. Laveder, M. Lawe, M. Licciardi, T. Lindner, R. P. Litchfield, S. L. Liu, X. Li, A. Longhin, L. Ludovici, X. Lu, T. Lux, L. N. Machado, L. Magaletti, K. Mahn, M. Malek, S. Manly, L. Maret, A. D. Marino, L. Marti-Magro, J. F. Martin, T. Maruyama, T. Matsubara, K. Matsushita, V. Matveev, C. Mauger, K. Mavrokoridis, E. Mazzucato, M. McCarthy, N. McCauley, J. McElwee, K. S. McFarland, C. McGrew, A. Mefodiev, C. Metelko, M. Mezzetto, A. Minamino, O. Mineev, S. Mine, M. Miura, L. Molina Bueno, S. Moriyama, J. Morrison, Th. A. Mueller, L. Munteanu, S. Murphy, Y. Nagai, T. Nakadaira, M. Nakahata, Y. Nakajima, A. Nakamura, K. G. Nakamura, K. Nakamura, Y. Nakano, S. Nakayama, T. Nakaya, K. Nakayoshi, C. Nantais, C. E. R. Naseby, T. V. Ngoc, K. Niewczas, K. Nishikawa, Y. Nishimura, E. Noah, T. S. Nonnenmacher, F. Nova, P. Novella, J. Nowak, J. C. Nugent, H. M. O’Keeffe, L. O’Sullivan, T. Odagawa, T. Ogawa, R. Okada, K. Okumura, T. Okusawa, S. M. Oser, R. A. Owen, Y. Oyama, V. Palladino, J. L. Palomino, V. Paolone, M. Pari, W. C. Parker, S. Parsa, J. Pasternak, P. Paudyal, M. Pavin, D. Payne, G. C. Penn, L. Pickering, C. Pidcott, G. Pintaudi, E. S. Pinzon Guerra, C. Pistillo, B. Popov, K. Porwit, M. Posiadala-Zezula, A. Pritchard, B. Quilain, T. Radermacher, E. Radicioni, B. Radics, P. N. Ratoff, E. Reinherz-Aronis, C. Riccio, E. Rondio, S. Roth, A. Rubbia, A. C. Ruggeri, C. A. Ruggles, A. Rychter, K. Sakashita, F. Sánchez, G. Santucci, C. M. Schloesser, K. Scholberg, J. Schwehr, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, D. Sgalaberna, R. Shah, A. Shaikhiev, F. Shaker, A. Shaykina, M. Shiozawa, W. Shorrock, A. Shvartsman, A. Smirnov, M. Smy, J. T. Sobczyk, H. Sobel, F. J. P. Soler, Y. Sonoda, J. Steinmann, S. Suvorov, A. Suzuki, S. Y. Suzuki, Y. Suzuki, A. A. Sztuc, M. Tada, M. Tajima, A. Takeda, Y. Takeuchi, H. K. Tanaka, H. A. Tanaka, S. Tanaka, Y. Tanihara, M. Tani, N. Teshima, L. F. Thompson, W. Toki, C. Touramanis, T. Towstego, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. Vagins, S. Valder, Z. Vallari, D. Vargas, G. Vasseur, C. Vilela, W. G. S. Vinning, T. Vladisavljevic, V. V. Volkov, T. Wachala, J. Walker, J. G. Walsh, Y. Wang, D. Wark, M. O. Wascko, A. Weber, R. Wendell, M. J. Wilking, C. Wilkinson, J. R. Wilson, R. J. Wilson, K. Wood, C. Wret, Y. Yamada, K. Yamamoto, C. Yanagisawa, G. Yang, T. Yano, K. Yasutome, S. Yen, N. Yershov, M. Yokoyama, T. Yoshida, M. Yu, A. Zalewska, J. Zalipska, K. Zaremba, G. Zarnecki, M. Ziembicki, E. D. Zimmerman, M. Zito, S. Zsoldos, and A. Zykova

Subjects
Other experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, dσ/dp and dσ/d cos(θ), and the total cross-sections in a limited phase-space in momentum and scattering angle (p > 300 MeV/c and θ ≤ 45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement.

Published
2020
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120. Long-baseline neutrino oscillation physics potential of the DUNE experiment

Author

B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero, F. Azfar, H. Back, J. J. Back, C. Backhouse, P. Baesso, L. Bagby, R. Bajou, S. Balasubramanian, P. Baldi, B. Bambah, F. Barao, G. Barenboim, G. J. Barker, W. Barkhouse, C. Barnes, G. Barr, J. Barranco Monarca, N. Barros, J. L. Barrow, A. Bashyal, V. Basque, F. Bay, J. L. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, D. Belver, N. Benekos, F. Bento Neves, J. Berger, S. Berkman, P. Bernardini, R. M. Berner, H. Berns, S. Bertolucci, M. Betancourt, Y. Bezawada, M. Bhattacharjee, B. Bhuyan, S. Biagi, J. Bian, M. Biassoni, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, B. Blanco Siffert, F. D. M. Blaszczyk, G. C. Blazey, E. Blucher, J. Boissevain, S. Bolognesi, T. Bolton, M. Bonesini, M. Bongrand, F. Bonini, A. Booth, C. Booth, S. Bordoni, A. Borkum, T. Boschi, N. Bostan, P. Bour, S. B. Boyd, D. Boyden, J. Bracinik, D. Braga, D. Brailsford, A. Brandt, J. Bremer, C. Brew, E. Brianne, S. J. Brice, C. Brizzolari, C. Bromberg, G. Brooijmans, J. Brooke, A. Bross, G. Brunetti, N. Buchanan, H. Budd, D. Caiulo, P. Calafiura, J. Calcutt, M. Calin, S. Calvez, E. Calvo, L. Camilleri, A. Caminata, M. Campanelli, D. Caratelli, G. Carini, B. Carlus, P. Carniti, I. Caro Terrazas, H. Carranza, A. Castillo, C. Castromonte, C. Cattadori, F. Cavalier, F. Cavanna, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, M. Chalifour, C. Chang, E. Chardonnet, A. Chatterjee, S. Chattopadhyay, J. Chaves, H. Chen, M. Chen, Y. Chen, D. Cherdack, C. Chi, S. Childress, A. Chiriacescu, K. Cho, S. Choubey, A. Christensen, D. Christian, G. Christodoulou, E. Church, P. Clarke, T. E. Coan, A. G. Cocco, J. A. B. Coelho, E. Conley, J. M. Conrad, M. Convery, L. Corwin, P. Cotte, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, E. Cristaldo, R. Cross, C. Cuesta, Y. Cui, D. Cussans, M. Dabrowski, H. da Motta, L. Da Silva Peres, C. David, Q. David, G. S. Davies, S. Davini, J. Dawson, K. De, R. M. De Almeida, P. Debbins, I. De Bonis, M. P. Decowski, A. de Gouvêa, P. C. De Holanda, I. L. De Icaza Astiz, A. Deisting, P. De Jong, A. Delbart, D. Delepine, M. Delgado, A. Dell’Acqua, P. De Lurgio, J. R. T. de Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, G. Deptuch, A. De Roeck, V. De Romeri, J. J. De Vries, R. Dharmapalan, M. Dias, F. Diaz, J. S. Díaz, S. Di Domizio, L. Di Giulio, P. Ding, L. Di Noto, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, N. Dokania, M. J. Dolinski, L. Domine, D. Douglas, F. Drielsma, D. Duchesneau, K. Duffy, P. Dunne, T. Durkin, H. Duyang, O. Dvornikov, D. A. Dwyer, A. S. Dyshkant, M. Eads, D. Edmunds, J. Eisch, S. Emery, A. Ereditato, C. O. Escobar, L. Escudero Sanchez, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, A. Falcone, C. Farnese, Y. Farzan, J. Felix, E. Fernandez-Martinez, P. Fernandez Menendez, F. Ferraro, L. Fields, A. Filkins, F. Filthaut, R. S. Fitzpatrick, W. Flanagan, B. Fleming, R. Flight, J. Fowler, W. Fox, J. Franc, K. Francis, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, S. Fuess, I. Furic, A. P. Furmanski, A. Gago, H. Gallagher, A. Gallego-Ros, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, R. Gandhi, R. Gandrajula, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, S. Gardiner, D. Gastler, G. Ge, B. Gelli, A. Gendotti, S. Gent, Z. Ghorbani-Moghaddam, D. Gibin, I. Gil-Botella, C. Girerd, A. K. Giri, D. Gnani, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. V. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, J. A. Gonzalez-Cuevas, M. C. Goodman, O. Goodwin, S. Goswami, C. Gotti, E. Goudzovski, C. Grace, M. Graham, E. Gramellini, R. Gran, E. Granados, A. Grant, C. Grant, D. Gratieri, P. Green, S. Green, L. Greenler, M. Greenwood, J. Greer, W. C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, W. Gu, V. Guarino, R. Guenette, A. Guglielmi, B. Guo, K. K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, S. Gwon, A. Habig, A. Hackenburg, H. Hadavand, R. Haenni, A. Hahn, J. Haigh, J. Haiston, T. Hamernik, P. Hamilton, J. Han, K. Harder, D. A. Harris, J. Hartnell, T. Hasegawa, R. Hatcher, E. Hazen, A. Heavey, K. M. Heeger, J. Heise, K. Hennessy, S. Henry, M. A. Hernandez Morquecho, K. Herner, L. Hertel, A. S. Hesam, J. Hewes, A. Higuera, T. Hill, S. J. Hillier, A. Himmel, J. Hoff, C. Hohl, A. Holin, E. Hoppe, G. A. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Huang, J. Hugon, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, A. Ioannisian, R. Itay, A. Izmaylov, E. James, B. Jargowsky, F. Jediny, C. Jesùs-Valls, X. Ji, L. Jiang, S. Jiménez, A. Jipa, A. Joglekar, C. Johnson, R. Johnson, B. Jones, S. Jones, C. K. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. Kaboth, I. Kadenko, F. Kamiya, G. Karagiorgi, A. Karcher, M. Karolak, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, N. Kazaryan, E. Kearns, P. Keener, K. J. Kelly, E. Kemp, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, A. Khvedelidze, D. Kim, B. King, B. Kirby, M. Kirby, J. Klein, K. Koehler, L. W. Koerner, S. Kohn, P. P. Koller, M. Kordosky, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, F. Krennrich, I. Kreslo, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, R. Kumar, C. Kuruppu, V. Kus, T. Kutter, A. Lambert, K. Lande, C. E. Lane, K. Lang, T. Langford, P. Lasorak, D. Last, C. Lastoria, A. Laundrie, A. Lawrence, I. Lazanu, R. LaZur, T. Le, J. Learned, P. LeBrun, G. Lehmann Miotto, R. Lehnert, M. A. Leigui de Oliveira, M. Leitner, M. Leyton, L. Li, S. Li, S. W. Li, T. Li, Y. Li, H. Liao, C. S. Lin, S. Lin, A. Lister, B. R. Littlejohn, J. Liu, S. Lockwitz, T. Loew, M. Lokajicek, I. Lomidze, K. Long, K. Loo, D. Lorca, T. Lord, J. M. LoSecco, W. C. Louis, K. B. Luk, X. Luo, N. Lurkin, T. Lux, V. P. Luzio, D. MacFarland, A. A. Machado, P. Machado, C. T. Macias, J. R. Macier, A. Maddalena, P. Madigan, S. Magill, K. Mahn, A. Maio, J. A. Maloney, G. Mandrioli, J. Maneira, L. Manenti, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, N. Martinez, D. A. Martinez Caicedo, S. Martynenko, K. Mason, A. Mastbaum, M. Masud, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, R. Mazza, A. Mazzacane, E. Mazzucato, E. McCluskey, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, A. Mefodiev, P. Mehta, P. Melas, M. Mellinato, O. Mena, S. Menary, H. Mendez, A. Menegolli, G. Meng, M. D. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, G. Michna, T. Miedema, J. Migenda, R. Milincic, W. Miller, J. Mills, C. Milne, O. Mineev, O. G. Miranda, S. Miryala, C. S. Mishra, S. R. Mishra, A. Mislivec, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. Molina, L. Molina Bueno, A. Montanari, C. Montanari, D. Montanari, L. M. Montano Zetina, J. Moon, M. Mooney, A. Moor, D. Moreno, B. Morgan, C. Morris, C. Mossey, E. Motuk, C. A. Moura, J. Mousseau, W. Mu, L. Mualem, J. Mueller, M. Muether, S. Mufson, F. Muheim, A. Muir, M. Mulhearn, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, S. Nagu, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, D. Navas-Nicolás, N. Nayak, M. Nebot-Guinot, L. Necib, K. Negishi, J. K. Nelson, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, D. Newhart, R. Nichol, E. Niner, K. Nishimura, A. Norman, A. Norrick, R. Northrop, P. Novella, J. A. Nowak, M. Oberling, A. Olivares Del Campo, A. Olivier, Y. Onel, Y. Onishchuk, J. Ott, L. Pagani, S. Pakvasa, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, S. Paramesvaran, S. Parke, Z. Parsa, M. Parvu, S. Pascoli, L. Pasqualini, J. Pasternak, J. Pater, C. Patrick, L. Patrizii, R. B. Patterson, S. J. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, S. J. M. Peeters, Y. Penichot, E. Pennacchio, A. Penzo, O. L. G. Peres, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, F. Piastra, L. Pickering, F. Pietropaolo, J. Pillow, J. Pinzino, R. Plunkett, R. Poling, X. Pons, N. Poonthottathil, S. Pordes, M. Potekhin, R. Potenza, B. V. K. S. Potukuchi, J. Pozimski, M. Pozzato, S. Prakash, T. Prakash, S. Prince, G. Prior, D. Pugnere, K. Qi, X. Qian, J. L. Raaf, R. Raboanary, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, M. Rajaoalisoa, I. Rakhno, H. T. Rakotondramanana, L. Rakotondravohitra, Y. A. Ramachers, R. Rameika, M. A. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, S. Ravat, H. Razafinime, J. S. Real, B. Rebel, D. Redondo, M. Reggiani-Guzzo, T. Rehak, J. Reichenbacher, S. D. Reitzner, A. Renshaw, S. Rescia, F. Resnati, A. Reynolds, G. Riccobene, L. C. J. Rice, K. Rielage, Y. Rigaut, D. Rivera, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, J. Rodriguez Rondon, A. J. Roeth, H. Rogers, S. Rosauro-Alcaraz, M. Rossella, J. Rout, S. Roy, A. Rubbia, C. Rubbia, B. Russell, J. Russell, D. Ruterbories, R. Saakyan, S. Sacerdoti, T. Safford, N. Sahu, P. Sala, N. Samios, M. C. Sanchez, D. A. Sanders, D. Sankey, S. Santana, M. Santos-Maldonado, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, V. Savinov, A. Scaramelli, A. Scarff, A. Scarpelli, T. Schaffer, H. Schellman, P. Schlabach, D. Schmitz, K. Scholberg, A. Schukraft, E. Segreto, J. Sensenig, I. Seong, A. Sergi, F. Sergiampietri, D. Sgalaberna, M. H. Shaevitz, S. Shafaq, M. Shamma, H. R. Sharma, R. Sharma, T. Shaw, C. Shepherd-Themistocleous, S. Shin, D. Shooltz, R. Shrock, L. Simard, N. Simos, J. Sinclair, G. Sinev, J. Singh, V. Singh, R. Sipos, F. W. Sippach, G. Sirri, A. Sitraka, K. Siyeon, D. Smargianaki, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, P. Snopok, M. Soares Nunes, H. Sobel, M. Soderberg, C. J. Solano Salinas, S. Söldner-Rembold, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, J. Soto-Oton, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, K. Spurgeon, R. Staley, M. Stancari, L. Stanco, H. M. Steiner, J. Stewart, B. Stillwell, J. Stock, F. Stocker, T. Stokes, M. Strait, T. Strauss, S. Striganov, A. Stuart, D. Summers, A. Surdo, V. Susic, L. Suter, C. M. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, R. Talaga, H. A. Tanaka, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tatar, R. Tayloe, A. M. Teklu, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, A. Thea, J. L. Thompson, C. Thorn, S. C. Timm, A. Tonazzo, M. Torti, M. Tortola, F. Tortorici, D. Totani, M. Toups, C. Touramanis, J. Trevor, W. H. Trzaska, Y. T. Tsai, Z. Tsamalaidze, K. V. Tsang, N. Tsverava, S. Tufanli, C. Tull, E. Tyley, M. Tzanov, M. A. Uchida, J. Urheim, T. Usher, M. R. Vagins, P. Vahle, G. A. Valdiviesso, E. Valencia, Z. Vallari, J. W. F. Valle, S. Vallecorsa, R. Van Berg, R. G. Van de Water, D. Vanegas Forero, F. Varanini, D. Vargas, G. Varner, J. Vasel, G. Vasseur, K. Vaziri, S. Ventura, A. Verdugo, S. Vergani, M. A. Vermeulen, M. Verzocchi, H. Vieira de Souza, C. Vignoli, C. Vilela, B. Viren, T. Vrba, T. Wachala, A. V. Waldron, M. Wallbank, H. Wang, J. Wang, Y. Wang, K. Warburton, D. Warner, M. Wascko, D. Waters, A. Watson, P. Weatherly, A. Weber, M. Weber, H. Wei, A. Weinstein, D. Wenman, M. Wetstein, M. R. While, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, C. Wilkinson, Z. Williams, F. Wilson, R. J. Wilson, J. Wolcott, T. Wongjirad, K. Wood, L. Wood, E. Worcester, M. Worcester, C. Wret, W. Wu, Y. Xiao, G. Yang, T. Yang, N. Yershov, K. Yonehara, T. Young, B. Yu, J. Yu, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, L. Zazueta, G. P. Zeller, J. Zennamo, K. Zeug, C. Zhang, M. Zhao, E. Zhivun, G. Zhu, E. D. Zimmerman, M. Zito, S. Zucchelli, J. Zuklin, V. Zutshi, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The sensitivity of the Deep Underground Neutrino Experiment (DUNE) to neutrino oscillation is determined, based on a full simulation, reconstruction, and event selection of the far detector and a full simulation and parameterized analysis of the near detector. Detailed uncertainties due to the flux prediction, neutrino interaction model, and detector effects are included. DUNE will resolve the neutrino mass ordering to a precision of 5 $$\sigma $$ σ , for all $$\delta _{\mathrm{CP}}$$ δ CP values, after 2 years of running with the nominal detector design and beam configuration. It has the potential to observe charge-parity violation in the neutrino sector to a precision of 3 $$\sigma $$ σ (5 $$\sigma $$ σ ) after an exposure of 5 (10) years, for 50% of all $$\delta _{\mathrm{CP}}$$ δ CP values. It will also make precise measurements of other parameters governing long-baseline neutrino oscillation, and after an exposure of 15 years will achieve a similar sensitivity to $$\sin ^{2} 2\theta _{13}$$ sin 2 2 θ 13 to current reactor experiments.

Published
2020
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121. Optimizing high-resolution Community Earth System Model on a heterogeneous many-core supercomputing platform

Author

S. Zhang, H. Fu, L. Wu, Y. Li, H. Wang, Y. Zeng, X. Duan, W. Wan, L. Wang, Y. Zhuang, H. Meng, K. Xu, P. Xu, L. Gan, Z. Liu, S. Wu, Y. Chen, H. Yu, S. Shi, S. Xu, W. Xue, W. Liu, Q. Guo, J. Zhang, G. Zhu, Y. Tu, J. Edwards, A. Baker, J. Yong, M. Yuan, Y. Yu, Q. Zhang, M. Li, D. Jia, G. Yang, Z. Wei, J. Pan, P. Chang, G. Danabasoglu, S. Yeager, N. Rosenbloom, and Y. Guo

Subjects
Geology, QE1-996.5
Abstract

With semiconductor technology gradually approaching its physical and thermal limits, recent supercomputers have adopted major architectural changes to continue increasing the performance through more power-efficient heterogeneous many-core systems. Examples include Sunway TaihuLight that has four management processing elements (MPEs) and 256 computing processing elements (CPEs) inside one processor and Summit that has two central processing units (CPUs) and six graphics processing units (GPUs) inside one node. Meanwhile, current high-resolution Earth system models that desperately require more computing power generally consist of millions of lines of legacy code developed for traditional homogeneous multicore processors and cannot automatically benefit from the advancement of supercomputer hardware. As a result, refactoring and optimizing the legacy models for new architectures become key challenges along the road of taking advantage of greener and faster supercomputers, providing better support for the global climate research community and contributing to the long-lasting societal task of addressing long-term climate change. This article reports the efforts of a large group in the International Laboratory for High-Resolution Earth System Prediction (iHESP) that was established by the cooperation of Qingdao Pilot National Laboratory for Marine Science and Technology (QNLM), Texas A&M University (TAMU), and the National Center for Atmospheric Research (NCAR), with the goal of enabling highly efficient simulations of the high-resolution (25 km atmosphere and 10 km ocean) Community Earth System Model (CESM-HR) on Sunway TaihuLight. The refactoring and optimizing efforts have improved the simulation speed of CESM-HR from 1 SYPD (simulation years per day) to 3.4 SYPD (with output disabled) and supported several hundred years of pre-industrial control simulations. With further strategies on deeper refactoring and optimizing for remaining computing hotspots, as well as redesigning architecture-oriented algorithms, we expect an equivalent or even better efficiency to be gained on the new platform than traditional homogeneous CPU platforms. The refactoring and optimizing processes detailed in this paper on the Sunway system should have implications for similar efforts on other heterogeneous many-core systems such as GPU-based high-performance computing (HPC) systems.

Published
2020
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122. Oxygenated products formed from OH-initiated reactions of trimethylbenzene: autoxidation and accretion

Author

Y. Wang, A. Mehra, J. E. Krechmer, G. Yang, X. Hu, Y. Lu, A. Lambe, M. Canagaratna, J. Chen, D. Worsnop, H. Coe, and L. Wang

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Gas-phase oxidation pathways and products of anthropogenic volatile organic compounds (VOCs), mainly aromatics, are the subject of intensive research, with attention paid to their contributions to secondary organic aerosol (SOA) formation and potentially new particle formation (NPF) in the urban atmosphere. In this study, a series of OH-initiated oxidation experiments of trimethylbenzene (TMB, C9H12) including 1,2,4-TMB, 1,3,5-TMB, 1,2,3-TMB, and 1,2,4-(methyl-D3)-TMBs (C9H9D3) were investigated in an oxidation flow reactor (OFR) in the absence and presence of NOx. Products were measured using a suite of state-of-the-art instruments, i.e. a nitrate-based chemical ionization–atmospheric pressure interface time-of-flight mass spectrometer (nitrate CI-APi-TOF), an iodide-adduct chemical ionization time-of-flight mass spectrometer (iodide CI-TOF) equipped with a Filter Inlet for Gases and AEROsols (FIGAERO), and a Vocus proton-transfer-reaction mass spectrometer (Vocus PTR). A large number of C9 products with 1–11 oxygen atoms and C18 products presumably formed from dimerization of C9 peroxy radicals were observed, hinting at the extensive existence of autoxidation and accretion reaction pathways in the OH-initiated oxidation reactions of TMBs. Oxidation products of 1,2,4-(methyl-D3)-TMBs with deuterium atoms in different methyl substituents were then used as a molecular basis to propose potential autoxidation reaction pathways. Accretion of C9 peroxy radicals is the most significant for aromatics with meta-substituents and the least for aromatics with ortho-substituents if the number and size of substituted groups are identical. The presence of NOx would suppress the formation of highly oxygenated molecules (HOMs) of C18 and enhance the formation of organonitrates and even dinitrate organic compounds. Our results show that the oxidation products of TMB are much more diverse and could be more oxygenated than the current mechanisms predict.

Published
2020
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123. Sterile neutrino oscillometry with Jinping

Author

M. V. Smirnov, Zh. J. Hu, J. J. Ling, Yu. N. Novikov, Z. Wang, and G. Yang

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The existence of sterile neutrino is an open question in neutrino physics up to now. The method of neutrino oscillometry provides a powerful tool to test the common 3 + 1 sterile neutrino hypothesis, i.e. three active flavors and one sterile flavor. There are several antineutrino sources which can be used for this method. One of them is the well known isotope chain of $$^{144}\mathrm{Ce}$$ 144Ce –$$^{144}{\mathrm{Pr}}$$ 144Pr with initial activity around 50–100 kCi. It has compact size and might be installed either outside or inside the detector. Another one is the short-lived isotope $$^8{\mathrm{Li}}$$ 8Li , which can be produced in nuclear reaction of a proton beam hitting a beryllium target. The lithium source has only the out-of-detector option due to its large size. The proposed Jinping water-based liquid scintillator detector will be used as a detection volume. Above experimental setups will allow us to cover the current best fit values of oscillation parameters with 90% C.L. At the same time, it is sensitive to the region of the Neutrino-4 result.

Published
2020
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124. Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling

Author

I. F. Gareev, O. A. Beylerli, G. Yang, and D. Zhang

Subjects
микро-рнк, длинные некодирующие рнк, студенистое ядро, генная экспрессия, полимеразная цепная реакция в реальном времени, коллагеназа ii типа, межпозвоночные диски, рнк расщепление, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background. With numerous extraction protocols for total RNA and RNA fractions, like microRNA (miRNA) and long non-coding RNA (lncRNA), available for various cell and tissue types, obtaining a high quantitative and qualitative yield from some special material, such as the nucleus pulposus, remains challenging. Nucleus pulposus is troublesome to manage in common RNA isolation protocols due to low cell content and high biopolymer concentrations, including proteoglycans and glycoproteins, which impair overall purity and yield. A major lack of reproducible methods for total and fraction RNA isolation directly from the nucleus pulposus impedes effective real-time PCR applications for downstream miRNA and lncRNA expression profiling in the course of intervertebral disc degeneration. In this study, we exploit the collagenase type II lytic properties to facilitate extraction of total and fraction RNA from the nucleus pulposus and compare results with the standard RNA isolation method.Materials and methods. Nucleus pulposus samples (n = 8) were obtained from September 2017 to December 2018 from patients with herniated discs in the lumbosacral spine diagnosed during surgery. Equal portions of samples were processed with the standard and original RNA isolation protocols.Results and discussion. Th e enzymatic lysis method for total and fraction RNA isolation from the nucleus pulposus of intervertebral discs demonstrated excellent integrity and high purity. No protein, polysaccharide or collagen contamination was detected.Conclusion. Th e method reported allows an improved quantitative and qualitative total and fraction RNA yield from the nucleus pulposus of intervertebral discs. Th e method can be used in future research on miRNA and lncRNA expression profiling with real-time PCR by improving the average cycle threshold value.

Published
2020
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125. Theia: an advanced optical neutrino detector

Author

M. Askins, Z. Bagdasarian, N. Barros, E. W. Beier, E. Blucher, R. Bonventre, E. Bourret, E. J. Callaghan, J. Caravaca, M. Diwan, S. T. Dye, J. Eisch, A. Elagin, T. Enqvist, V. Fischer, K. Frankiewicz, C. Grant, D. Guffanti, C. Hagner, A. Hallin, C. M. Jackson, R. Jiang, T. Kaptanoglu, J. R. Klein, Yu. G. Kolomensky, C. Kraus, F. Krennrich, T. Kutter, T. Lachenmaier, B. Land, K. Lande, J. G. Learned, V. Lozza, L. Ludhova, M. Malek, S. Manecki, J. Maneira, J. Maricic, J. Martyn, A. Mastbaum, C. Mauger, F. Moretti, J. Napolitano, B. Naranjo, M. Nieslony, L. Oberauer, G. D. Orebi Gann, J. Ouellet, T. Pershing, S. T. Petcov, L. Pickard, R. Rosero, M. C. Sanchez, J. Sawatzki, S. H. Seo, M. Smiley, M. Smy, A. Stahl, H. Steiger, M. R. Stock, H. Sunej, R. Svoboda, E. Tiras, W. H. Trzaska, M. Tzanov, M. Vagins, C. Vilela, Z. Wang, J. Wang, M. Wetstein, M. J. Wilking, L. Winslow, P. Wittich, B. Wonsak, E. Worcester, M. Wurm, G. Yang, M. Yeh, E. D. Zimmerman, S. Zsoldos, and K. Zuber

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract New developments in liquid scintillators, high-efficiency, fast photon detectors, and chromatic photon sorting have opened up the possibility for building a large-scale detector that can discriminate between Cherenkov and scintillation signals. Such a detector could reconstruct particle direction and species using Cherenkov light while also having the excellent energy resolution and low threshold of a scintillator detector. Situated deep underground, and utilizing new techniques in computing and reconstruction, this detector could achieve unprecedented levels of background rejection, enabling a rich physics program spanning topics in nuclear, high-energy, and astrophysics, and across a dynamic range from hundreds of keV to many GeV. The scientific program would include observations of low- and high-energy solar neutrinos, determination of neutrino mass ordering and measurement of the neutrino CP-violating phase $$\delta $$ δ , observations of diffuse supernova neutrinos and neutrinos from a supernova burst, sensitive searches for nucleon decay and, ultimately, a search for neutrinoless double beta decay, with sensitivity reaching the normal ordering regime of neutrino mass phase space. This paper describes Theia, a detector design that incorporates these new technologies in a practical and affordable way to accomplish the science goals described above.

Published
2020
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126. DROUGHT MONITORING IN SHANDONG PROVINCE BASED ON MODIFIED TEMPERATURE-VEGETATION-SOIL MOISTURE DRYNESS INDEX (TVMDI)

Author

H. Wan, Z. D. Wang, P. Guo, B. Wang, X. C. Li, C. H. Meng, and G. Yang

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Drought is one of the frequent natural disasters in Shandong province, which is characterized by high frequency and wide range. In response to frequent droughts that are not monitored in time, monitoring the changes of drought is of great significance to agricultural production and social development. This study used the Temperature-Vegetation-soil Moisture Dryness Index (TVMDI) model, combined with the optical MODIS land surface temperature, vegetation index, surface albedo data and microwave FY-3B soil moisture data, to monitor the drought of Shandong province in 2016. The precipitation and temperature data of weather station were used to validate the monitoring results. The results show that, in 2016, the drought in Shandong province mainly occurred in winter and spring, and the drought in summer was alleviated. From the perspective of space, the northern Shandong and the Shandong peninsula areas are relatively humid with less drought time, while the local areas in the central and southern Shandong province suffer from severe drought with longer drought time. From the perspective of correlation with meteorological factors, the average correlation coefficient between TVMDI and precipitation can reach 0.45, and the average correlation coefficient between TVMDI and temperature can reach 0.63.

Published
2020
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127. THE METHODOLOGY AND APPLICATION OF NEW THREE-DIMENSIONAL GUIDE SYSTEM AND INTELLIGENT SERVICE IN INTELLIGENT SCENIC SPOT: A CASE STUDY OF QIXING SCENIC SPOT IN GUILIN CITY, GUANGXI, CHINA

Author

B. S. Li, S. K. Wu, X. Li, J. H. Guo, B. L. Zhu, and W. G. Yang

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Nowadays, 3D navigation systems and intelligent services are costly to use, and the accuracy of intelligent navigation does not meet the needs of tourists, and the practicality is not strong. Based on the current situation of the construction of the smart scenic navigation system and the actual needs of tourists, this study determines the main principles and methods of the tour guide system and intelligent services. Taking a certain scenic spot as the specific research object, the A* algorithm is used to solve the path. By optimizing the online gracing service of the arc gis server network, the appropriate data interpolation method is used to improve the accuracy of the elevation data of the scenic spot, and the characteristics of the three-dimensional symbol system are combined. The 3D symbol design system is optimized, and a high-precision 3D navigation map model is established. Finally, the corresponding 3D tour guide system and scenic area intelligent service are designed based on this, and the principle and application flow of the intelligent scenic area navigation system construction are summarized. The three-dimensional map model and its navigation system designed by this research institute reduce the risk of tourists during the tour, improve the quality and efficiency of the tour, and provide a practical service optimization solution for the smart scenic three-dimensional navigation system. The construction and use cost of the high-precision three-dimensional navigation system in the scenic spot is reduced.

Published
2020
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128. Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals

Author

X. Li, X. Fu, G. Yang, and M. Du

Subjects
adipogenesis, fibro-adipogenic progenitors, skeletal muscle, marbling, meat, Animal culture, SF1-1100
Abstract

In the livestock industry, subcutaneous and visceral fat pads are considered as wastes, while intramuscular fat or marbling fat is essential for improving flavor and palatability of meat. Thus, strategies for optimizing fat deposition are needed. Intramuscular adipocytes provide sites for lipid deposition and marbling formation. In the present article, we addressed the origin and markers of intramuscular adipocyte progenitors – fibro-adipogenic progenitors (FAPs), as well as the latest progresses in mechanisms regulating the proliferation and differentiation of intramuscular FAPs. Finally, by targeting intramuscular FAPs, possible nutritional manipulations to improve marbling fat deposition are discussed. Despite recent progresses, the properties and regulation of intramuscular FAPs in livestock remain poorly understood and deserve further investigation.

Published
2020
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129. Integrated simulation analysis of the HL-2M high-parameter hybrid scenario

Author

Y. Zhong, G. Yang, X. Gong, P. Yu, Q. Tan, Q. Huang, P. Zheng, L. Yin, T. Yang, Z. Gao, Z. Wang, and M. Xu

Subjects
OMFIT, impurity concentration, pedestal density, HL-2M, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

On the basis of the OMFIT integrated simulation platform and the parameters of the HL-2M device, a hybrid scenario with a typical safety factor q profile is simulated using the joint injection method of neutral beam and electron cyclotron wave with a normalized toroidal beta ( β _N ) of 2.39. At the same time, by analyzing the effect of impurity concentration ( Z _eff ) and pedestal density ( n _e,ped ) on confinement, a higher parameters hybrid scenario is obtained, with β _N reaching 3.118. The research results indicate that the turbulent stabilization effect caused by Z _eff gradually decreases from strong to weak with the increase of Z _eff , whereas the radiation power loss increases linearly as Z _eff increases. Consequently, there exists an optimal Z _eff value for optimal confinement. In addition, it is found that the optimal Z _eff value decreases with the increase of n _e,ped . The research results are crucial for the HL-2M device to accomplish the 1 MA advanced scenario discharge target, and they serve as a reference for future impurity seeding experiments.

Published
2023
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131. New Superconductivity Study Findings Have Been Reported by G. Yang and Co-Researchers (Numerical and Experimental Analysis of CSR of Transformer Type for Bidirectional Reactive Power Compensation)

Subjects
Superconductors -- Reports -- Analysis, Transformers -- Reports -- Analysis, Corporate social responsibility -- Reports -- Analysis, Electronics
Abstract

2016 MAY 31 (VerticalNews) -- By a News Reporter-Staff News Editor at Electronics Newsweekly -- Investigators publish new report on Superconductivity. According to news reporting originating from Baoding, People's Republic [...]

Published
2016

133. Late‐onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbanceHow to cite this article: Tsai ACH, Morel CF, Scharer G, Yang M, Lerner‐Ellis JP, Rosenblatt DS, Thomas JA. 2007. Late‐onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance. Am J Med Genet Part A 143A:2430–2434.

Author

Tsai, Anne Chun‐Hui, Morel, Chantal F., Scharer, Gunter, Yang, Michael, Lerner‐Ellis, Jordan P., Rosenblatt, David S., and Thomas, Janet A.

Abstract

We report on the case of a 36‐year‐old Hispanic woman with a spinal cord infarct, who was subsequently diagnosed with methylmalonic aciduria and homocystinuria, cblC type (cblC). Mutation analysis revealed c.271dupA and c.482G > A mutations in the MMACHC gene. The patient had a past medical history significant for joint hypermobility, arthritis, bilateral cataracts, unilateral hearing loss, anemia, frequent urinary tract infections, and mental illness. There was no significant past history of mental retardation, failure to thrive, or seizure disorder as reported in classic cases of cblC. Prior to the thrombotic incident, the patient experienced increased paresthesia in the lower extremities, myelopathy, and impaired gait. Given her previous psychiatric history, she was misdiagnosed with malingering until hemiplegia and incontinence became apparent. The authors would like to emphasize the recognition of a neuropsychiatric presentation in late onset cblC. Ten other reported late onset cases with similar presentations are also reviewed. © 2007 Wiley‐Liss, Inc.

Published
2007
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135. OpenArray v1.0: a simple operator library for the decoupling of ocean modeling and parallel computing

Author

X. Huang, D. Wang, Q. Wu, Y. Li, S. Zhang, Y. Chen, M. Wang, Y. Gao, Q. Tang, Z. Fang, Z. Song, and G. Yang

Subjects
Geology, QE1-996.5
Abstract

Rapidly evolving computational techniques are making a large gap between scientific aspiration and code implementation in climate modeling. In this work, we design a simple computing library to bridge the gap and decouple the work of ocean modeling from parallel computing. This library provides 12 basic operators that feature user-friendly interfaces, effective programming, and implicit parallelism. Several state-of-the-art computing techniques, including computing graph and just-in-time compiling, are employed to parallelize the seemingly serial code and speed up the ocean models. These operator interfaces are designed using native Fortran programming language to smooth the learning curve. We further implement a highly readable and efficient ocean model that contains only 1860 lines of code but achieves a 91 % parallel efficiency in strong scaling and 99 % parallel efficiency in weak scaling with 4096 Intel CPU cores. This ocean model also exhibits excellent scalability on the heterogeneous Sunway TaihuLight supercomputer. This work presents a promising alternative tool for the development of ocean models.

Published
2019
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136. Extraction of Exosomes from Glioblastoma Multiforme Patients’ Blood Plasma

Author

I. F. Gareev, O. A. Beylerli, Sh. Zhao, G. Yang, J. Sun, A. T. Beilerli, and Sh. M. Safin

Subjects
глиобластома, новообразования, экзосомы, плазма, экстракция, центрифугирование, биомаркеры, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction. Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumour in adults associated with a poor prognosis. Exosomes have been shown to be useful non-invasive biomarkers for the diagnosis and prognosis of tumours, GBM included. Exosomes play a role of biological carriers which can perform various tasks through various signalling pathways of carcinogenesis, such as PI3K/AKT, SOX2, PTEN, ERK and STAT3.Materials and methods. Exosomes were isolated from blood plasma taken from patients diagnosed with GBM prior to surgical resection.Results and discussion. Plasma exosomes from patients with GBM had spherical shape and varied in size from 40 to 100 nm matching the exosomes’ morphological characteristics. The combination of ultrafiltration and double ultracentrifugation makes it possible to extract exosome examples from plasma without the presence of contaminating particles over 100 nm in size; the shape and size of these vesicles match the characteristics of exosomes isolated from other biological fluids.Conclusion. The experimental protocol for the extraction of exosomes from GBM patients’ plasma described here proves effective as a method used to ensure the purity of exosomes. Applying this method offers further opportunities for research into the role of exosomes in GBM pathogenesis. Equally this method can be used in research involving other human pathologies.

Published
2019
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137. Input Rationality Analysis of Three Degree of freedom Parallel Mechanism with Limbs of Embedding Structures

Author

G. Yang, J. Zhang, W. Li, and K. Qi

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Three degrees of freedom (3-DoF) parallel mechanism (PM) with limbs of embedding structures is a kind of PM with a coupling relationship between limbs. In order to obtain a more desirable motion, the analysis of its actuated pairs shall be conducted. However, the fact that the existence of limbs coupling results in non-unique limb group, this mechanism has multiple limb groups. In this regard, the traditional input selection theory is not suitable for direct application in the input rationality analysis. Aiming to avoid this, a general extended input selection theory and limb group selection rule are proposed. The former tackles the traditional input selection theory which is not suitable for analyzing the input of PM with limbs of embedding structures since it does not take the influence of group into consideration, whereas the latter makes the calculation of the former easier. Based on the extended input selection theory and the limb group selection rule, the input and configuration of the 3-DoF PM with limbs of embedding structures are improved.

Published
2019
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138. FCC Physics Opportunities

Author

A. Abada, M. Abbrescia, S. S. AbdusSalam, I. Abdyukhanov, J. Abelleira Fernandez, A. Abramov, M. Aburaia, A. O. Acar, P. R. Adzic, P. Agrawal, J. A. Aguilar-Saavedra, J. J. Aguilera-Verdugo, M. Aiba, I. Aichinger, G. Aielli, A. Akay, A. Akhundov, H. Aksakal, J. L. Albacete, S. Albergo, A. Alekou, M. Aleksa, R. Aleksan, R. M. Alemany Fernandez, Y. Alexahin, R. G. Alía, S. Alioli, N. Alipour Tehrani, B. C. Allanach, P. P. Allport, M. Altınlı, W. Altmannshofer, G. Ambrosio, D. Amorim, O. Amstutz, L. Anderlini, A. Andreazza, M. Andreini, A. Andriatis, C. Andris, A. Andronic, M. Angelucci, F. Antinori, S. A. Antipov, M. Antonelli, M. Antonello, P. Antonioli, S. Antusch, F. Anulli, L. Apolinário, G. Apollinari, A. Apollonio, D. Appelö, R. B. Appleby, Ara. Apyan, Arm. Apyan, A. Arbey, A. Arbuzov, G. Arduini, V. Arı, S. Arias, N. Armesto, R. Arnaldi, S. A. Arsenyev, M. Arzeo, S. Asai, E. Aslanides, R. W. Aßmann, D. Astapovych, M. Atanasov, S. Atieh, D. Attié, B. Auchmann, A. Audurier, S. Aull, S. Aumon, S. Aune, F. Avino, G. Avrillaud, G. Aydın, A. Azatov, G. Azuelos, P. Azzi, O. Azzolini, P. Azzurri, N. Bacchetta, E. Bacchiocchi, H. Bachacou, Y. W. Baek, V. Baglin, Y. Bai, S. Baird, M. J. Baker, M. J. Baldwin, A. H. Ball, A. Ballarino, S. Banerjee, D. P. Barber, D. Barducci, P. Barjhoux, D. Barna, G. G. Barnaföldi, M. J. Barnes, A. Barr, J. Barranco García, J. Barreiro Guimarães da Costa, W. Bartmann, V. Baryshevsky, E. Barzi, S. A. Bass, A. Bastianin, B. Baudouy, F. Bauer, M. Bauer, T. Baumgartner, I. Bautista-Guzmán, C. Bayındır, F. Beaudette, F. Bedeschi, M. Béguin, I. Bellafont, L. Bellagamba, N. Bellegarde, E. Belli, E. Bellingeri, F. Bellini, G. Bellomo, S. Belomestnykh, G. Bencivenni, M. Benedikt, G. Bernardi, J. Bernardi, C. Bernet, J. M. Bernhardt, C. Bernini, C. Berriaud, A. Bertarelli, S. Bertolucci, M. I. Besana, M. Besançon, O. Beznosov, P. Bhat, C. Bhat, M. E. Biagini, J.-L. Biarrotte, A. Bibet Chevalier, E. R. Bielert, M. Biglietti, G. M. Bilei, B. Bilki, C. Biscari, F. Bishara, O. R. Blanco-García, F. R. Blánquez, F. Blekman, A. Blondel, J. Blümlein, T. Boccali, R. Boels, S. A. Bogacz, A. Bogomyagkov, O. Boine-Frankenheim, M. J. Boland, S. Bologna, O. Bolukbasi, M. Bomben, S. Bondarenko, M. Bonvini, E. Boos, B. Bordini, F. Bordry, G. Borghello, L. Borgonovi, S. Borowka, D. Bortoletto, D. Boscherini, M. Boscolo, S. Boselli, R. R. Bosley, F. Bossu, C. Botta, L. Bottura, R. Boughezal, D. Boutin, G. Bovone, I. Božović Jelisavc̆ić, A. Bozbey, C. Bozzi, D. Bozzini, V. Braccini, S. Braibant-Giacomelli, J. Bramante, P. Braun-Munzinger, J. A. Briffa, D. Britzger, S. J. Brodsky, J. J. Brooke, R. Bruce, P. Brückman De Renstrom, E. Bruna, O. Brüning, O. Brunner, K. Brunner, P. Bruzzone, X. Buffat, E. Bulyak, F. Burkart, H. Burkhardt, J.-P. Burnet, F. Butin, D. Buttazzo, A. Butterworth, M. Caccia, Y. Cai, B. Caiffi, V. Cairo, O. Cakir, R. Calaga, S. Calatroni, G. Calderini, G. Calderola, A. Caliskan, D. Calvet, M. Calviani, J. M. Camalich, P. Camarri, M. Campanelli, T. Camporesi, A. C. Canbay, A. Canepa, E. Cantergiani, D. Cantore-Cavalli, M. Capeans, R. Cardarelli, U. Cardella, A. Cardini, C. M. Carloni Calame, F. Carra, S. Carra, A. Carvalho, S. Casalbuoni, J. Casas, M. Cascella, P. Castelnovo, G. Castorina, G. Catalano, V. Cavasinni, E. Cazzato, E. Cennini, A. Cerri, F. Cerutti, J. Cervantes, I. Chaikovska, J. Chakrabortty, M. Chala, M. Chamizo-Llatas, H. Chanal, D. Chanal, S. Chance, A. Chancé, P. Charitos, J. Charles, T. K. Charles, S. Chattopadhyay, R. Chehab, S. V. Chekanov, N. Chen, A. Chernoded, V. Chetvertkova, L. Chevalier, G. Chiarelli, G. Chiarello, M. Chiesa, P. Chiggiato, J. T. Childers, A. Chmielińska, A. Cholakian, P. Chomaz, M. Chorowski, W. Chou, M. Chrzaszcz, E. Chyhyrynets, G. Cibinetto, A. K. Ciftci, R. Ciftci, R. Cimino, M. Ciuchini, P. J. Clark, Y. Coadou, M. Cobal, A. Coccaro, J. Cogan, E. Cogneras, F. Collamati, C. Colldelram, P. Collier, J. Collot, R. Contino, F. Conventi, C. T. A. Cook, L. Cooley, G. Corcella, A. S. Cornell, G. H. Corral, H. Correia-Rodrigues, F. Costanza, P. Costa Pinto, F. Couderc, J. Coupard, N. Craig, I. Crespo Garrido, A. Crivellin, J. F. Croteau, M. Crouch, E. Cruz Alaniz, B. Curé, J. Curti, D. Curtin, M. Czech, C. Dachauer, R. T. D’Agnolo, M. Daibo, A. Dainese, B. Dalena, A. Daljevec, W. Dallapiazza, L. D’Aloia Schwartzentruber, M. Dam, G. D’Ambrosio, S. P. Das, S. DasBakshi, W. da Silva, G. G. da Silveira, V. D’Auria, S. D’Auria, A. David, T. Davidek, A. Deandrea, J. de Blas, C. J. Debono, S. De Curtis, N. De Filippis, D. de Florian, S. Deghaye, S. J. de Jong, C. Del Bo, V. Del Duca, D. Delikaris, F. Deliot, A. Dell’Acqua, L. Delle Rose, M. Delmastro, E. De Lucia, M. Demarteau, D. Denegri, L. Deniau, D. Denisov, H. Denizli, A. Denner, D. d’Enterria, G. de Rijk, A. De Roeck, F. Derue, O. Deschamps, S. Descotes-Genon, P. S. B. Dev, J. B. de Vivie de Régie, R. K. Dewanjee, A. Di Ciaccio, A. Di Cicco, B. M. Dillon, B. Di Micco, P. Di Nezza, S. Di Vita, A. Doblhammer, A. Dominjon, M. D’Onofrio, F. Dordei, A. Drago, P. Draper, Z. Drasal, M. Drewes, L. Duarte, I. Dubovyk, P. Duda, A. Dudarev, L. Dudko, D. Duellmann, M. Dünser, T. du Pree, M. Durante, H. Duran Yildiz, S. Dutta, F. Duval, J. M. Duval, Ya. Dydyshka, B. Dziewit, S. Eisenhardt, M. Eisterer, T. Ekelof, D. El Khechen, S. A. Ellis, J. Ellis, J. A. Ellison, K. Elsener, M. Elsing, Y. Enari, C. Englert, H. Eriksson, K. J. Eskola, L. S. Esposito, O. Etisken, E. Etzion, P. Fabbricatore, A. Falkowski, A. Falou, J. Faltova, J. Fan, L. Fanò, A. Farilla, R. Farinelli, S. Farinon, D. A. Faroughy, S. D. Fartoukh, A. Faus-Golfe, W. J. Fawcett, G. Felici, L. Felsberger, C. Ferdeghini, A. M. Fernandez Navarro, A. Fernández-Téllez, J. Ferradas Troitino, G. Ferrara, R. Ferrari, L. Ferreira, P. Ferreira da Silva, G. Ferrera, F. Ferro, M. Fiascaris, S. Fiorendi, C. Fiorio, O. Fischer, E. Fischer, W. Flieger, M. Florio, D. Fonnesu, E. Fontanesi, N. Foppiani, K. Foraz, D. Forkel-Wirth, S. Forte, M. Fouaidy, D. Fournier, T. Fowler, J. Fox, P. Francavilla, R. Franceschini, S. Franchino, E. Franco, A. Freitas, B. Fuks, K. Furukawa, S. V. Furuseth, E. Gabrielli, A. Gaddi, M. Galanti, E. Gallo, S. Ganjour, Jia. Gao, Jie. Gao, V. Garcia Diaz, M. García Pérez, L. García Tabarés, C. Garion, M. V. Garzelli, I. Garzia, S. M. Gascon-Shotkin, G. Gaudio, P. Gay, S.-F. Ge, T. Gehrmann, M. H. Genest, R. Gerard, F. Gerigk, H. Gerwig, P. Giacomelli, S. Giagu, E. Gianfelice-Wendt, F. Gianotti, F. Giffoni, S. S. Gilardoni, M. Gil Costa, M. Giovannetti, M. Giovannozzi, P. Giubellino, G. F. Giudice, A. Giunta, L. K. Gladilin, S. Glukhov, J. Gluza, G. Gobbi, B. Goddard, F. Goertz, T. Golling, D. Gonçalves, V. P. Goncalves, R. Gonçalo, L. A. Gonzalez Gomez, S. Gorgi Zadeh, G. Gorine, E. Gorini, S. A. Gourlay, L. Gouskos, F. Grancagnolo, A. Grassellino, A. Grau, E. Graverini, H. M. Gray, Ma. Greco, Mi. Greco, J.-L. Grenard, O. Grimm, C. Grojean, V. A. Gromov, J. F. Grosse-Oetringhaus, A. Grudiev, K. Grzanka, J. Gu, D. Guadagnoli, V. Guidi, S. Guiducci, G. Guillermo Canton, Y. O. Günaydin, R. Gupta, R. S. Gupta, J. Gutierrez, J. Gutleber, C. Guyot, V. Guzey, C. Gwenlan, Ch. Haberstroh, B. Hacışahinoğlu, B. Haerer, K. Hahn, T. Hahn, A. Hammad, C. Han, M. Hance, A. Hannah, P. C. Harris, C. Hati, S. Haug, J. Hauptman, V. Haurylavets, H-J. He, A. Hegglin, B. Hegner, K. Heinemann, S. Heinemeyer, C. Helsens, Ana. Henriques, And. Henriques, P. Hernandez, R. J. Hernández-Pinto, J. Hernandez-Sanchez, T. Herzig, I. Hiekkanen, W. Hillert, T. Hoehn, M. Hofer, W. Höfle, F. Holdener, S. Holleis, B. Holzer, D. K. Hong, C. G. Honorato, S. C. Hopkins, J. Hrdinka, F. Hug, B. Humann, H. Humer, T. Hurth, A. Hutton, G. Iacobucci, N. Ibarrola, L. Iconomidou-Fayard, K. Ilyina-Brunner, J. Incandela, A. Infantino, V. Ippolito, M. Ishino, R. Islam, H. Ita, A. Ivanovs, S. Iwamoto, A. Iyer, S. Izquierdo Bermudez, S. Jadach, D. O. Jamin, P. Janot, P. Jarry, A. Jeff, P. Jenny, E. Jensen, M. Jensen, X. Jiang, J. M. Jiménez, M. A. Jones, O. R. Jones, J. M. Jowett, S. Jung, W. Kaabi, M. Kado, K. Kahle, L. Kalinovskaya, J. Kalinowski, J. F. Kamenik, K. Kannike, S. O. Kara, H. Karadeniz, V. Karaventzas, I. Karpov, S. Kartal, A. Karyukhin, V. Kashikhin, J. Katharina Behr, U. Kaya, J. Keintzel, P. A. Keinz, K. Keppel, R. Kersevan, K. Kershaw, H. Khanpour, S. Khatibi, M. Khatiri Yanehsari, V. V. Khoze, J. Kieseler, A. Kilic, A. Kilpinen, Y.-K. Kim, D. W. Kim, U. Klein, M. Klein, F. Kling, N. Klinkenberg, S. Klöppel, M. Klute, V. I. Klyukhin, M. Knecht, B. Kniehl, F. Kocak, C. Koeberl, A. M. Kolano, A. Kollegger, K. Kołodziej, A. A. Kolomiets, J. Komppula, I. Koop, P. Koppenburg, M. Koratzinos, M. Kordiaczyńska, M. Korjik, O. Kortner, P. Kostka, W. Kotlarski, C. Kotnig, T. Köttig, A. V. Kotwal, A. D. Kovalenko, S. Kowalski, J. Kozaczuk, G. A. Kozlov, S. S. Kozub, A. M. Krainer, T. Kramer, M. Krämer, M. Krammer, A. A. Krasnov, F. Krauss, K. Kravalis, L. Kretzschmar, R. M. Kriske, H. Kritscher, P. Krkotic, H. Kroha, M. Kucharczyk, S. Kuday, A. Kuendig, G. Kuhlmann, A. Kulesza, Mi. Kumar, Mu. Kumar, A. Kusina, S. Kuttimalai, M. Kuze, T. Kwon, F. Lackner, M. Lackner, E. La Francesca, M. Laine, G. Lamanna, S. La Mendola, E. Lançon, G. Landsberg, P. Langacker, C. Lange, A. Langner, A. J. Lankford, J. P. Lansberg, T. Lari, P. J. Laycock, P. Lebrun, A. Lechner, K. Lee, S. Lee, R. Lee, T. Lefevre, P. Le Guen, T. Lehtinen, S. B. Leith, P. Lenzi, E. Leogrande, C. Leonidopoulos, I. Leon-Monzon, G. Lerner, O. Leroy, T. Lesiak, P. Lévai, A. Leveratto, E. Levichev, G. Li, S. Li, R. Li, D. Liberati, M. Liepe, D. A. Lissauer, Z. Liu, A. Lobko, E. Locci, E. Logothetis Agaliotis, M. P. Lombardo, A. J. Long, C. Lorin, R. Losito, A. Louzguiti, I. Low, D. Lucchesi, M. T. Lucchini, A. Luciani, M. Lueckhof, A. J. G. Lunt, M. Luzum, D. A. Lyubimtsev, M. Maggiora, N. Magnin, M. A. Mahmoud, F. Mahmoudi, J. Maitre, V. Makarenko, A. Malagoli, J. Malclés, L. 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Putti, A. Pyarelal, H. Quack, M. Quispe, A. Racioppi, H. Rafique, V. Raginel, M. Raidal, N. S. Ramírez-Uribe, M. J. Ramsey-Musolf, R. Rata, P. Ratoff, F. Ravotti, P. Rebello Teles, M. Reboud, S. Redaelli, E. Renner, A. E. Rentería-Olivo, M. Rescigno, J. Reuter, A. Ribon, A. M. Ricci, W. Riegler, S. Riemann, B. Riemann, T. Riemann, J. M. Rifflet, R. A. Rimmer, R. Rinaldesi, L. Rinolfi, O. Rios Rubiras, T. Risselada, A. Rivetti, L. Rivkin, T. Rizzo, T. Robens, F. Robert, A. J. Robson, E. Rochepault, C. Roda, G. Rodrigo, M. Rodríguez-Cahuantzi, C. Rogan, M. Roig, S. Rojas-Torres, J. Rojo, G. Rolandi, G. Rolando, P. Roloff, A. Romanenko, A. Romanov, F. Roncarolo, A. Rosado Sanchez, G. Rosaz, L. Rossi, A. Rossi, R. Rossmanith, B. Rousset, C. Royon, X. Ruan, I. Ruehl, V. Ruhlmann-Kleider, R. Ruiz, L. Rumyantsev, R. Ruprecht, A. I. Ryazanov, A. Saba, R. Sadykov, D. Saez de Jauregui, M. Sahin, B. Sailer, M. Saito, F. Sala, G. P. Salam, J. Salfeld-Nebgen, C. A. Salgado, S. Salini, J. M. Sallese, T. Salmi, A. Salzburger, O. A. Sampayo, S. Sanfilippo, J. Santiago, E. Santopinto, R. Santoro, A. Sanz Ull, X. Sarasola, I. H. Sarpün, M. Sauvain, S. Savelyeva, R. Sawada, G. F. R. Sborlini, A. Schaffer, M. Schaumann, M. Schenk, C. Scheuerlein, I. Schienbein, K. Schlenga, H. Schmickler, R. Schmidt, D. Schoerling, A. Schoning, T. Schörner-Sadenius, M. Schott, D. Schulte, P. Schwaller, C. Schwanenberger, P. Schwemling, N. Schwerg, L. Scibile, A. Sciuto, E. Scomparin, C. Sebastiani, B. Seeber, M. Segreti, P. Selva, M. Selvaggi, C. Senatore, A. Senol, L. Serin, M. Serluca, N. Serra, A. Seryi, L. Sestini, A. Sfyrla, M. Shaposhnikov, E. Shaposhnikova, B. Yu. Sharkov, D. Shatilov, J. Shelton, V. Shiltsev, I. P. Shipsey, G. D. Shirkov, A. Shivaji, D. Shwartz, T. Sian, S. Sidorov, A. Siemko, L. Silvestrini, N. Simand, F. Simon, B. K. Singh, A. Siódmok, Y. Sirois, E. Sirtori, R. Sirvinskaite, B. Sitar, T. Sjöstrand, P. Skands, E. Skordis, K. Skovpen, M. Skrzypek, E. Slade, P. Slavich, R. Slovak, V. Smaluk, V. Smirnov, W. Snoeys, L. Soffi, P. Sollander, O. Solovyanov, H. K. Soltveit, H. Song, P. Sopicki, M. Sorbi, L. Spallino, M. Spannowsky, B. Spataro, P. Sphicas, H. Spiesberger, P. Spiller, M. Spira, T. Srivastava, J. Stachel, A. Stakia, J. L. Stanyard, E. Starchenko, A. Yu. Starikov, A. M. Staśto, M. Statera, R. Steerenberg, J. Steggemann, A. Stenvall, F. Stivanello, D. Stöckinger, L. S. Stoel, M. Stöger-Pollach, B. Strauss, M. Stuart, G. Stupakov, S. Su, A. Sublet, K. Sugita, L. Sulak, M. K. Sullivan, S. Sultansoy, T. Sumida, K. Suzuki, G. Sylva, M. J. Syphers, A. Sznajder, M. Taborelli, N. A. Tahir, E. Tal Hod, M. Takeuchi, C. Tambasco, J. Tanaka, K. Tang, I. Tapan, S. Taroni, G. F. Tartarelli, G. Tassielli, L. Tavian, T. M. Taylor, G. N. Taylor, A. M. Teixeira, G. Tejeda-Muñoz, V. I. Telnov, R. Tenchini, H. H. J. ten Kate, K. Terashi, A. Tesi, M. Testa, C. Tetrel, D. Teytelman, J. Thaler, A. Thamm, S. Thomas, M. T. Tiirakari, V. Tikhomirov, D. Tikhonov, H. Timko, V. Tisserand, L. M. Tkachenko, J. Tkaczuk, J. Ph. Tock, B. Todd, E. Todesco, R. Tomás Garcia, D. Tommasini, G. Tonelli, F. Toral, T. Torims, R. Torre, Z. Townsend, R. Trant, D. Treille, L. Trentadue, A. Tricoli, A. Tricomi, W. Trischuk, I. S. Tropin, B. Tuchming, A. A. Tudora, B. Turbiarz, I. Turk Cakir, M. Turri, T. Tydecks, J. Usovitsch, J. Uythoven, R. Vaglio, A. Valassi, F. Valchkova, M. A. Valdivia Garcia, P. Valente, R. U. Valente, A.-M. Valente-Feliciano, G. Valentino, L. Vale Silva, J. M. Valet, R. Valizadeh, J. W. F. Valle, S. Vallecorsa, G. Vallone, M. van Leeuwen, U. H. van Rienen, L. van Riesen-Haupt, M. Varasteh, L. Vecchi, P. Vedrine, G. Velev, R. Veness, A. Ventura, W. Venturini Delsolaro, M. Verducci, C. B. Verhaaren, C. Vernieri, A. P. Verweij, O. Verwilligen, O. Viazlo, A. Vicini, G. Viehhauser, N. Vignaroli, M. Vignolo, A. Vitrano, I. Vivarelli, S. Vlachos, M. Vogel, D. M. Vogt, V. Völkl, P. Volkov, G. Volpini, J. von Ahnen, G. Vorotnikov, G. G. Voutsinas, V. Vysotsky, U. Wagner, R. Wallny, L.-T. Wang, R. Wang, K. Wang, B. F. L. Ward, T. P. Watson, N. K. Watson, Z. Wa̧s, C. Weiland, S. Weinzierl, C. P. Welsch, J. Wenninger, M. Widorski, U. A. Wiedemann, H.-U. Wienands, G. Wilkinson, P. H. Williams, A. Winter, A. Wohlfahrt, T. Wojtoń, D. Wollmann, J. Womersley, D. Woog, X. Wu, A. Wulzer, M. K. Yanehsari, G. Yang, H. J. Yang, W.-M. Yao, E. Yazgan, V. Yermolchik, Ay. Yilmaz, Al. Yilmaz, H.-D. Yoo, S. A. Yost, T. You, C. Young, T.-T. Yu, F. Yu, A. Zaborowska, S. G. Zadeh, M. Zahnd, M. Zanetti, L. Zanotto, L. Zawiejski, P. Zeiler, M. Zerlauth, S. M. Zernov, G. Zevi Dell Porta, Z. Zhang, Y. Zhang, C. Zhang, H. Zhang, Z. Zhao, Y.-M. Zhong, J. Zhou, D. Zhou, P. Zhuang, G. Zick, F. Zimmermann, J. Zinn-Justin, L. Zivkovic, A. V. Zlobin, M. Zobov, J. Zupan, J. Zurita, and The FCC Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.

Published
2019
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139. Intra-regional transport of black carbon between the south edge of the North China Plain and central China during winter haze episodes

Author

H. Zheng, S. Kong, F. Wu, Y. Cheng, Z. Niu, S. Zheng, G. Yang, L. Yao, Q. Yan, J. Wu, M. Zheng, N. Chen, K. Xu, Y. Yan, D. Liu, D. Zhao, T. Zhao, Y. Bai, S. Li, and S. Qi

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Black carbon (BC), which is formed from the incomplete combustion of fuel sources (mainly fossil fuel, biofuel and open biomass burning), is a chemically inert optical absorber in the atmosphere. It has significant impacts on global climate, regional air quality and human health. During transportation, its physical and chemical characteristics as well as its sources change dramatically. To investigate the properties of BC (i.e., mass concentration, sources and optical properties) during intra-regional transport between the southern edge of the North China Plain (SE-NCP) and central China (CC), simultaneous BC observations were conducted in a megacity (Wuhan – WH) in CC, in three borderline cities (Xiangyang – XY, Suixian – SX and Hong'an – HA; from west to east) between the SE-NCP and CC, and in a city (Luohe – LH) in the SE-NCP during typical winter haze episodes. Using an Aethalometer, the highest equivalent BC (eBC) mass concentrations and the highest aerosol absorption coefficients (σabs) were found in LH in the SE-NCP, followed by the borderline cities (XY, SX and HA) and WH. The levels, sources, optical properties (i.e., σabs and absorption Ångström exponent, AAE) and geographic origins of eBC were different between clean and polluted periods. Compared with clean days, higher eBC levels (26.4 %–163 % higher) and σabs (18.2 %–236 % higher) were found during pollution episodes due to the increased combustion of fossil fuels (increased by 51.1 %–277 %), which was supported by the decreased AAE values (decreased by 7.40 %–12.7 %). The conditional bivariate probability function (CBPF) and concentration-weighted trajectory (CWT) results showed that the geographic origins of biomass burning (BCbb) and fossil fuel (BCff) combustion-derived BC were different. Air parcels from the south dominated for border sites during clean days, with contributions of 46.0 %–58.2 %, whereas trajectories from the northeast showed higher contributions (37.5 %–51.2 %) during pollution episodes. At the SE-NCP site (LH), transboundary influences from the south (CC) exhibited a more frequent impact (with air parcels from this direction comprising 47.8 % of all parcels) on the ambient eBC levels during pollution episodes. At WH, eBC was mainly from the northeast transport route throughout the observation period. Two transportation cases showed that the mass concentrations of eBC, BCff and σabs all increased, from upwind to downwind, whereas AAE decreased. This study highlights that intra-regional prevention and control for dominant sources at each specific site should be considered in order to improve the regional air quality.

Published
2019
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140. TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Author

Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, and David J. Rawlings

Subjects
Genetics, QH426-470, Cytology, QH573-671
Abstract

Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clinically favorable hereditary persistence of fetal hemoglobin (HPFH) phenotype. We developed TALENs targeting the homologous HBG promoters to de-repress fetal hemoglobin. Transfection of human CD34+ cells with TALEN mRNA resulted in indel generation in HBG1 (43%) and HBG2 (74%) including the 13-bp HPFH deletion (∼6%). Erythroid differentiation of edited cells revealed a 4.6-fold increase in γ-hemoglobin expression as detected by HPLC. Assessment of TALEN-edited CD34+ cells in vivo in a humanized mouse model demonstrated sustained presence of indels in hematopoietic cells up to 24 weeks. Indel rates remained unchanged following secondary transplantation consistent with editing of long-term repopulating stem cells (LT-HSCs). Human γ-hemoglobin expressing F cells were detected by flow cytometry approximately 50% more frequently in edited animals compared to mock. Together, these findings demonstrate that TALEN-mediated indel generation in the γ-hemoglobin promoter leads to high levels of fetal hemoglobin expression in vitro and in vivo, suggesting that this approach can provide therapeutic benefit in patients with SCD or β-thalassemia. Keywords: TALEN, hemoglobinopathy, HBG, hemoglobin, HPFH, SCD, sickle cell disease, thalassemia, gene editing, HSC

Published
2019
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141. Application of the Fengyun 3 C GNSS occultation sounder for assessing the global ionospheric response to a magnetic storm event

Author

W. Bai, G. Wang, Y. Sun, J. Shi, G. Yang, X. Meng, D. Wang, Q. Du, X. Wang, J. Xia, Y. Cai, C. Liu, W. Li, C. Wu, D. Zhao, and D. Wu

Subjects
Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract

The rapid advancement of global navigation satellite system (GNSS) occultation technology in recent years has made it one of the most advanced space-based remote sensing technologies of the 21st century. GNSS radio occultation has many advantages, including all-weather operation, global coverage, high vertical resolution, high precision, long-term stability, and self-calibration. Data products from GNSS occultation sounding can greatly enhance ionospheric observations and contribute to space weather monitoring, forecasting, modeling, and research. In this study, GNSS occultation sounder (GNOS) results from a radio occultation sounding payload aboard the Fengyun 3 C (FY3-C) satellite were compared with ground-based ionosonde observations. Correlation coefficients for peak electron density (NmF2) derived from GNOS Global Position System (GPS) and Beidou navigation system (BDS) products with ionosonde data were higher than 0.9, and standard deviations were less than 20 %. Global ionospheric effects of the strong magnetic storm event in March 2015 were analyzed using GNOS results supported by ionosonde observations. The magnetic storm caused a significant disturbance in NmF2 level. Suppressed daytime and nighttime NmF2 levels indicated mainly negative storm conditions. In two longitude section zones of geomagnetic inclination between 40 and 80∘, the results of average NmF2 observed by GNOS and ground-based ionosondes showed the same basic trends during the geomagnetic storm and confirmed the negative effect of this storm event on the ionosphere. The analysis demonstrates the reliability of the GNSS radio occultation sounding instrument GNOS aboard the FY3-C satellite and confirms the utility of ionosphere products from GNOS for statistical and event-specific ionospheric physical analyses. Future FY3 series satellites and increasing numbers of Beidou navigation satellites will provide increasing GNOS occultation data on the ionosphere, which will contribute to ionosphere research and forecasting applications.

Published
2019
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142. Evaluation of Potato virus X mild mutants for cross protection against severe infection in China

Author

Q. Q. Cong, Y. Wang, J. Liu, Y. F. Lan, Z. K. Guo, J. G. Yang, X.-D. Li, and Y. P. Tian

Subjects
Cross protection, Potato virus X, RNA dependent RNA polymerase, Virulence, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Cross protection is a promising alternative to control plant viral diseases. One critical factor limiting the application of cross protection is the availability of attenuated mutants or mild strains. Potato virus X (PVX) infects many crops and induces huge economic losses to agricultural production. However, researches on the variability and mechanism of PVX virulence are scarce. Methods The mutants were obtained by introducing mutations into the RNA dependent RNA polymerase (RdRp) gene of PVX via site-directed mutagenesis. Attenuated mutants were screen according to their symptoms in Nicotiana benthamiana plants. The protection efficacy against severe infection were evaluated with interval of 5, 10 and 15 days. Results Among the 40 mutants obtained, four mutants carrying substitutions of either Glu46, Asn863, Asn968 or Glu1001 to Ala in PVX RdRp showed drastically attenuated symptom, accompanying with reduced accumulation levels of coat protein, plus- and minus-sense RNAs. When the interval between protective and challenging inoculations was 15 days, mutant E1001A (with substitution of Glu1001 to Ala in RdRp) provided complete protection against severe infection in both Nicotiana benthamiana and tomato, while E46A (Glu46 mutated to Ala) provided incomplete protection. To reduce the risk of reverse mutation, we constructed mutant dM which carries double mutations of both Glu46 and Glu1001 to Ala in RdRp. The mutant dM could provide effective protection against severe PVX infection. Conclusion Mutations of Glu46, Asn863, Asn968 or Glu1001 to Ala in PVX RdRp significantly reduced the viral symptoms. Mutants E1001A and E46A could provide effective protection against wild type PVX in both Nicotiana benthamiana and tomato. These results provide theoretical and practical bases for the control of PVX via cross protection.

Published
2019
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143. A proxy for atmospheric daytime gaseous sulfuric acid concentration in urban Beijing

Author

Y. Lu, C. Yan, Y. Fu, Y. Chen, Y. Liu, G. Yang, Y. Wang, F. Bianchi, B. Chu, Y. Zhou, R. Yin, R. Baalbaki, O. Garmash, C. Deng, W. Wang, T. Petäjä, V.-M. Kerminen, J. Jiang, M. Kulmala, and L. Wang

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Gaseous sulfuric acid (H2SO4) is known as one of the key precursors for atmospheric new particle formation (NPF) processes, but its measurement remains challenging. Therefore, a proxy method that is able to derive gaseous sulfuric acid concentrations from parameters that can be measured relatively easily and accurately is highly desirable for the atmospheric chemistry community. Although such methods are available for clean atmospheric environments, a proxy that works well in a polluted atmosphere, such as that found in Chinese megacities, is yet to be developed. In this study, the gaseous sulfuric acid concentration was measured in February–March 2018, in urban Beijing using a nitrate based – long time-of-flight chemical ionization mass spectrometer (LToF-CIMS). A number of atmospheric parameters were recorded concurrently including the ultraviolet radiation B (UVB) intensity, the concentrations of O3, NOx (sum of NO and NO2), SO2, and HONO, and aerosol particle number size distributions. A proxy for atmospheric daytime gaseous sulfuric acid concentration was derived via a statistical analysis method using the UVB intensity, [SO2], the condensation sink (CS), [O3], and [HONO] (or [NOx]) as the predictor variables, where square brackets denote the concentrations of the corresponding species. In this proxy method, we considered the formation of gaseous sulfuric acid from reactions of SO2 and OH radicals during the daytime, and the loss of gaseous sulfuric acid due to its condensation onto the preexisting particles. In addition, we explored the formation of OH radicals from the conventional gas-phase photochemistry using O3 as a proxy and from the photolysis of HONO using HONO (and subsequently NOx) as a proxy. Our results showed that the UVB intensity and [SO2] are dominant factors in the production of gaseous sulfuric acid, and that the simplest proxy could be constructed with the UVB intensity and [SO2] alone. When the OH radical production from both homogenously and heterogeneously formed precursors were considered, the relative errors were reduced by up to 20 %.

Published
2019
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144. Robust Optimization for Micromachine Design Problems Involving Multimodal Distributions

Author

Z. L. Huang, J. W. Zhang, Tarun Kumar, T. G. Yang, S. G. Deng, and F. Y. Li

Subjects
Probabilistic model, multimodal distribution, robust optimization, micromachine design, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The conventional robust optimization methods usually focus on problems with unimodal random variables. In real applications, input random variables may follow multimodal distributions with multiple peaks in their probability density. When multimodal random variables are involved, the conventional methods, such as the mean-variance-based methods, will be not accurate. This paper presents an efficient robust optimization method, which provides a potential computational tool for engineering problems involving multimodal random variables. A robustness metric is formulated by introducing the concept of accepting/rejecting the limit to calculate the failure probability of the performance response, which can directly capture the multimodal characteristics of the performance. A second-order higher moment method is presented to efficiently conduct the probability calculation in the inner loop of design optimization. The proposed decoupling strategy drives the probability calculation and the design optimization sequentially and alternately. This method is applied to the three micromachine design problems, including a sweat-rate sensor, a piezoelectric sensor, and an image sensing module. The numerical results show that the method has excellent engineering practicality due to the comprehensive performance in terms of efficiency, accuracy, and convergence.

Published
2019
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145. A Lagrangian approach towards extracting signals of urban CO2 emissions from satellite observations of atmospheric column CO2 (XCO2): X-Stochastic Time-Inverted Lagrangian Transport model ('X-STILT v1')

Author

D. Wu, J. C. Lin, B. Fasoli, T. Oda, X. Ye, T. Lauvaux, E. G. Yang, and E. A. Kort

Subjects
Geology, QE1-996.5
Abstract

Urban regions are responsible for emitting significant amounts of fossil fuel carbon dioxide (FFCO2), and emissions at the finer, city scales are more uncertain than those aggregated at the global scale. Carbon-observing satellites may provide independent top-down emission evaluations and compensate for the sparseness of surface CO2 observing networks in urban areas. Although some previous studies have attempted to derive urban CO2 signals from satellite column-averaged CO2 data (XCO2) using simple statistical measures, less work has been carried out to link upwind emission sources to downwind atmospheric columns using atmospheric models. In addition to Eulerian atmospheric models that have been customized for emission estimates over specific cities, the Lagrangian modeling approach – in particular, the Lagrangian particle dispersion model (LPDM) approach – has the potential to efficiently determine the sensitivity of downwind concentration changes to upwind sources. However, when applying LPDMs to interpret satellite XCO2, several issues have yet to be addressed, including quantifying uncertainties in urban XCO2 signals due to receptor configurations and errors in atmospheric transport and background XCO2.In this study, we present a modified version of the Stochastic Time-Inverted Lagrangian Transport (STILT) model, X-STILT, for extracting urban XCO2 signals from NASA's Orbiting Carbon Observatory 2 (OCO-2) XCO2 data. X-STILT incorporates satellite profiles and provides comprehensive uncertainty estimates of urban XCO2 enhancements on a per sounding basis. Several methods to initialize receptor/particle setups and determine background XCO2 are presented and discussed via sensitivity analyses and comparisons. To illustrate X-STILT's utilities and applications, we examined five OCO-2 overpasses over Riyadh, Saudi Arabia, during a 2-year time period and performed a simple scaling factor-based inverse analysis. As a result, the model is able to reproduce most observed XCO2 enhancements. Error estimates show that the 68 % confidence limit of XCO2 uncertainties due to transport (horizontal wind plus vertical mixing) and emission uncertainties contribute to ∼ 33 % and ∼ 20 % of the mean latitudinally integrated urban signals, respectively, over the five overpasses, using meteorological fields from the Global Data Assimilation System (GDAS). In addition, a sizeable mean difference of −0.55 ppm in background derived from a previous study employing simple statistics (regional daily median) leads to a ∼ 39 % higher mean observed urban signal and a larger posterior scaling factor. Based on our signal estimates and associated error impacts, we foresee X-STILT serving as a tool for interpreting column measurements, estimating urban enhancement signals, and carrying out inverse modeling to improve quantification of urban emissions.

Published
2018
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146. Cooperative trajectory shaping guidance law for multiple anti-ship missiles

Author

G. Yang, Y. Fang, W. Ma, S. Zhu, and W. Fu

Subjects
Aerospace Engineering
Abstract

To enhance the performance of anti-ship missiles cooperative attack, this paper proposes a finite-time trajectory shaping-based cooperative guidance law (TSCGL). Firstly, the cooperative guidance model is established on segmented linearisation of the missile’s heading angle. Then, a trajectory shaping guidance law for a single missile is derived by a weighted optimal energy cost function and Schwarz inequality. On this basis, a finite-time TSCGL is proposed combined with trajectory shaping technology and finite-time theory. The desirable finite-time convergence performance can ensure a simultaneous attack. Through an improved method of time-to-go estimation, it is independent of small-angle assumption and relaxes the launching conditions of the missiles. Additionally, the proposed finite-time TSCGL can achieve better damage performance through energy management. Finally, simulation results demonstrate the effectiveness and superiority of the proposed finite-time TSCGL.

Published
2023

147. New Radiotherapy Data Have Been Reported by G. Yang and Co-Authors (Dosimetric coverage of the prostate, normal tissue sparing, and acute toxicity with high-dose-rate brachytherapy for large prostate volumes)

Subjects
Brachytherapy, Toxicity, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2015 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news originating from Newnan, Georgia, [...]

Published
2015

150. Findings from G. Yang and Co-Authors Broaden Understanding of Rheumatoid Arthritis (Does Socioeconomic Status Affect Outcomes in Early Inflammatory Arthritis? Data from a Canadian Multisite Suspected Rheumatoid Arthritis Inception Cohort)

Subjects
Rheumatoid factor, Arthritis -- Patient outcomes, Social class, Health
Abstract

By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Arthritis have been presented. According to news reporting originating in London, Canada, by NewsRx journalists, [...]

Published
2015

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