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102. Effects of combining immunocastration and β-adrenergic agonists on the meat quality of Nellore cattle

Author

Mazon, Madeline R., primary, Antonelo, Daniel S., additional, Gómez, Juan F.M., additional, Nubiato, Keni E.Z., additional, Balage, Juliana M., additional, Silva, Henrique B., additional, Tapp, William N., additional, Leme, Paulo R., additional, Goulart, Rodrigo S., additional, Fukumasu, Heidge, additional, Johnson, Bradley J., additional, Pesce, Domingos M.C., additional, and Silva, Saulo L., additional

Published
2019
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111. Metabolomic signature of spermatozoa established during holding time is responsible for differences in boar sperm freezability†

Author

Torres, Mariana A, Pedrosa, Ana Carolina, Novais, Francisco José, Alkmin, Diego V, Cooper, Bruce R, Yasui, George S, Fukumasu, Heidge, Machaty, Zoltan, and de Andrade, André F C

Abstract

Holding at room temperature is the first step in most boar semen cryopreservation protocols. It is well accepted that a holding time (HT) of 24 h increases sperm cryotolerance. However, the effect of HT on ejaculates with different freezability is not entirely clear. The aim of this study was to understand how HT influences spermatic and seminal plasma metabolite profiles of boar ejaculates and how these possible changes affect freezability. A total of 27 ejaculates were collected and extended to 1:1 (v: v) with BTS and split into two aliquots. The first aliquot was cryopreserved without HT (0 h), and the second was held at 17°C for 24 h before cryopreservation. Spermatozoa and seminal plasma were collected by centrifugation at two times, before HT (0 h) and after HT (24 h), and subsequently frozen until metabolite extraction and UPLC–MS analysis. After thawing, the semen samples were evaluated for kinetics, membrane integrity, mitochondrial potential, membrane lipid peroxidation, and fluidity. The ejaculates were then allocated into two phenotypes (good ejaculate freezers [GEF] and poor ejaculate freezers [PEF]) based on the percent reduction in sperm quality (%RSQ) as determined by the difference in total motility and membrane integrity between raw and post-thaw samples cryopreserved after 24 h of HT. The metabolic profile of the seminal plasma did not seem to influence ejaculate freezability, but that of the spermatozoa were markedly different between GEF and PEF. We identified a number of metabolic markers in the sperm cells (including inosine, hypoxanthine, creatine, ADP, niacinamide, spermine, and 2-methylbutyrylcarnitine) that were directly related to the improvement of ejaculate freezability during HT; these were components of metabolic pathways associated with energy production. Furthermore, PEF showed an upregulation in the arginine and proline as well as the glutathione metabolism pathways. These findings help to better understand the effect of HT on boar sperm freezability and propose prospective metabolic markers that may predict freezability; this has implications in both basic and applied sciences.Acquisition of freezability of boar sperm occurs during holding time and involves changes in energy metabolism pathways.Creatine can be phosphorylated by ATP in Creatine phosphate, mainly at the mitochondria. Creatine phosphate is an alternative source for ADP phosphorylation in ATP. The Hypoxanthine-Inosine pathway is a different source of AMP–ADP–ATP conversion. Spermine increases the activation of cAMP, which can increase the energy production by the electron transport chain. Niacinamide is a precursor of NAD+, playing a role in the Krebs cycle and the electron transport chain. The 2-Methylbutyrylcarnitine is a product of isoleucine degradation and a source of succinate. GEF 0 h—good ejaculate freezer cryopreserved after 0 h of holding time at 17°C; GEF 24 h—good ejaculate freezer cryopreserved after 24 h of holding time at 17°C; PEF 0 h—poor ejaculate freezer cryopreserved after 0 h of holding time at 17°C; PEF 24 h— poor ejaculate freezer cryopreserved after 24 h of holding time at 17°C.

Published
2022
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112. Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil

Author

Marques Rossi, Gabriel Augusto, Oliveira Silva, Higor, Gamero Aguilar, Carlos Eduardo, Lázaro Rochetti, Arina, Pascoe, Ben, Méric, Guillaume, Mourkas, Evangelos, Hitchings, Matthew D., Mathias, Luis Antonio, de Azevedo Ruiz, Vera Letticie, Fukumasu, Heidge, Sheppard, Samuel K., Centola Vidal, Ana Maria, Marques Rossi, Gabriel Augusto, Oliveira Silva, Higor, Gamero Aguilar, Carlos Eduardo, Lázaro Rochetti, Arina, Pascoe, Ben, Méric, Guillaume, Mourkas, Evangelos, Hitchings, Matthew D., Mathias, Luis Antonio, de Azevedo Ruiz, Vera Letticie, Fukumasu, Heidge, Sheppard, Samuel K., and Centola Vidal, Ana Maria

Abstract

The genomes of 262 Bacillus cereus isolates were analyzed including 69 isolates sampled from equipment, raw milk and dairy products from Brazil. The population structure of isolates showed strains belonging to known phylogenetic groups II, III, IV, V and VI. Almost all the isolates obtained from dairy products belonged to group III. Investigation of specific alleles revealed high numbers of isolates carrying toxin-associated genes including cytK (53.62%), hblA (59.42%), hblC (44.93%), hblD (53.62%), nheA (84.06%), nheB (89.86%) and nheC (84.06%) with isolates belonging to groups IV and V having significant higher prevalence of hblACD and group IV of CytK genes. Strains from dairy products had significantly lower prevalence of CytK and hblACD genes compared to isolates from equipment and raw milk/bulk tanks. Genes related to sucrose metabolism were detected at higher frequency in isolates obtained from raw milk compared to strains from equipment and utensils. The population genomic analysis demonstrated the diversity of strains and variability of putative function among B. cereus group isolates in Brazilian dairy production, with large numbers of strains potentially able to cause foodborne illness. This detailed information will contribute to targeted interventions to reduce milk contamination and spoilage associated with B. cereus in Brazil.

Published
2018
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115. Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil

Author

Rossi, Gabriel Augusto Marques, primary, Silva, Higor Oliveira, additional, Aguilar, Carlos Eduardo Gamero, additional, Rochetti, Arina Lázaro, additional, Pascoe, Ben, additional, Méric, Guillaume, additional, Mourkas, Evangelos, additional, Hitchings, Matthew D, additional, Mathias, Luis Antonio, additional, de Azevedo Ruiz, Vera Letticie, additional, Fukumasu, Heidge, additional, Sheppard, Samuel K, additional, and Vidal, Ana Maria Centola, additional

Published
2017
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118. Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency

Author

Mota, Lúcio Flávio Macedo, primary, Bonafé, Cristina Moreira, additional, Alexandre, Pâmela Almeida, additional, Santana, Miguel Henrique, additional, Novais, Francisco José, additional, Toriyama, Erika, additional, Pires, Aldrin Vieira, additional, da Luz Silva, Saulo, additional, Leme, Paulo Roberto, additional, Ferraz, José Bento Sterman, additional, and Fukumasu, Heidge, additional

Published
2017
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121. Erratum to::Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle

Author

Alexandre, Pamela A., Kogelman, Lisette J. A., Santana, Miguel H. A., Passarelli, Danielle, Pulz, Lidia H., Fantinato-Neto, Paulo, Silva, Saulo Luz, Leme, Paulo R., Strefezzi, Ricardo F., Coutinho, Luiz L., Ferraz, Jose B. S., Eler, Joanir P., Kadarmideen, Haja N., Fukumasu, Heidge, Alexandre, Pamela A., Kogelman, Lisette J. A., Santana, Miguel H. A., Passarelli, Danielle, Pulz, Lidia H., Fantinato-Neto, Paulo, Silva, Saulo Luz, Leme, Paulo R., Strefezzi, Ricardo F., Coutinho, Luiz L., Ferraz, Jose B. S., Eler, Joanir P., Kadarmideen, Haja N., and Fukumasu, Heidge

Published
2016

122. Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with feed conversion ratio in beef cattle

Author

Satana, Miguel Henrique de Almedia, Junior, Gerson Antônio Oliveira, Cesar, Aline Silva Mello, Freua, Mateus Castelani, Gomes, Rodrigo da Costra, Silva, Saulo da Luz e, Leme, Paulo Roberto, Fukumasu, Heidge, Carvalho, Minos Esperandio, Ventura, Ricardo Vierira, Coutinho, Luiz Lehmann, Kadarmideen, Haja, Ferraz, José Bento Sterman, Satana, Miguel Henrique de Almedia, Junior, Gerson Antônio Oliveira, Cesar, Aline Silva Mello, Freua, Mateus Castelani, Gomes, Rodrigo da Costra, Silva, Saulo da Luz e, Leme, Paulo Roberto, Fukumasu, Heidge, Carvalho, Minos Esperandio, Ventura, Ricardo Vierira, Coutinho, Luiz Lehmann, Kadarmideen, Haja, and Ferraz, José Bento Sterman

Published
2016

123. System biology approach to detect and assign biological functions and regulator genes to feed efficiency traits in Nellore cattle

Author

Alexandre, Pâmela, Kogelman, Lisette, Santana, Miguel, Eler, Joanir, Kadarmideen, Haja, and Fukumasu, Heidge

Abstract

The objective of this study was to use a system biology approach to identify biological mechanisms involved on feed efficiency in Nellore cattle and its possible regulator genes. Two modules of co-expressed and highly inter-connected genes correlated to feed efficiency were identified as well as five regulator genes.

Published
2014

124. Genome-wide CNV analysis reveals variants associated with growth traits in Bos indicus

Author

Zhou, Yang, primary, Utsunomiya, Yuri T., additional, Xu, Lingyang, additional, Hay, El Hamidi abdel, additional, Bickhart, Derek M., additional, Alexandre, Pamela Almeida, additional, Rosen, Benjamin D., additional, Schroeder, Steven G., additional, Carvalheiro, Roberto, additional, de Rezende Neves, Haroldo Henrique, additional, Sonstegard, Tad S., additional, Van Tassell, Curtis P., additional, Ferraz, José Bento Sterman, additional, Fukumasu, Heidge, additional, Garcia, Jose Fernando, additional, and Liu, George E., additional

Published
2016
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125. Erratum to: Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle

Author

Alexandre, Pamela A., primary, Kogelman, Lisette J. A., additional, Santana, Miguel H. A., additional, Passarelli, Danielle, additional, Pulz, Lidia H., additional, Fantinato-Neto, Paulo, additional, Silva, Saulo Luz, additional, Leme, Paulo R., additional, Strefezzi, Ricardo F., additional, Coutinho, Luiz L., additional, Ferraz, José B. S., additional, Eler, Joanir P., additional, Kadarmideen, Haja N., additional, and Fukumasu, Heidge, additional

Published
2016
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126. Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle

Author

Alexandre, Pamela A., Kogelman, Lisette, Santana, Miguel H. A., Passarelli, Danielle, Pulz, Lidia H., Fantinato-Neto, Paulo, Silva, Paulo L., Leme, Paulo R., Strefezzi, Ricardo F., Coutinho, Luiz L., Ferraz, José B. S., Eler, Joanie P., Kadarmideen, Haja, Fukumasu, Heidge, Alexandre, Pamela A., Kogelman, Lisette, Santana, Miguel H. A., Passarelli, Danielle, Pulz, Lidia H., Fantinato-Neto, Paulo, Silva, Paulo L., Leme, Paulo R., Strefezzi, Ricardo F., Coutinho, Luiz L., Ferraz, José B. S., Eler, Joanie P., Kadarmideen, Haja, and Fukumasu, Heidge

Published
2015

127. Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle

Author

Alexandre, Pamela A., primary, Kogelman, Lisette J. A., additional, Santana, Miguel H. A., additional, Passarelli, Danielle, additional, Pulz, Lidia H., additional, Fantinato-Neto, Paulo, additional, Silva, Paulo L., additional, Leme, Paulo R., additional, Strefezzi, Ricardo F., additional, Coutinho, Luiz L., additional, Ferraz, José B. S., additional, Eler, Joanie P., additional, Kadarmideen, Haja N., additional, and Fukumasu, Heidge, additional

Published
2015
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128. Brazilian Journal of Veterinary Pathology

Author

Cassali, Geovanni Dantas, Lavalle, Gleidice E., De Nardi, Andrigo B., Ferreira, Enio, Bertagnolli, Angélica Cavalheiro, Lima, Alessandra Estrela da Silva, Alessi, Antonio C., Daleck, Carlos R., Salgado, Breno S., Fernandes, Cristina G., Sobral, Renata A., Amorim, Renée L., Gamba, Conrado O., Damasceno, Karine Araújo, Auler, Patricia de Alencar, Magalhães, Georgia M., Silva, Juliana O., Raposo, Josiane B., Ferreira, Ana M. R., Oliveira, Luciana O., Malm, Christina, Zuccari, Debora Aparecida Pires de Campos, Tanaka, Neide M., Ribeiro, Lorena R., Campos, Liliane Cunha, Souza, Cristina Maria de, Leite, Juliana S., Soares, Luciana M. C., Cavalcanti, Mariana F., Fonteles, Zilmara G. C., Schuch, Isabel D., Paniago, Juliana, Oliveira, Taismara S., Terra, Erika M., Castanheira, Thais L. L., Felix, Anelize O. C., Carvalho, Gabriel D., Guim, Thomas N., Guim, Tainã N., Garrido, Eduardo, Fernandes, Simone C., Maia, Frederico C. L., Dagli, Maria L. Z., Rocha, Noeme S., Fukumasu, Heidge, Grandi, Fabrizio, Machado, João P., Silva, Silvana M. M. S., Bezerril, Juliana Evangelista, Frehse, Michele S., Almeida, Elan Cardozo Paes de, and Campos, Cecília Bonolo de

Subjects
dogs, Mammary neoplasms, animal, medical oncology
Abstract

Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-10T18:30:55Z No. of bitstreams: 1 Consenso.pdf: 1884898 bytes, checksum: bcdbc659df1c1845ee705b8b9160deb2 (MD5) Made available in DSpace on 2012-02-10T18:30:55Z (GMT). No. of bitstreams: 1 Consenso.pdf: 1884898 bytes, checksum: bcdbc659df1c1845ee705b8b9160deb2 (MD5) Previous issue date: 2011-06 The purpose of this paper is to establish criteria that could guide the diagnosis, prognosis and treatment of canine mammary neoplasias. It was elaborated during the Mammary Pathology Meeting: Diagnosis, Prognosis and Treatment of the Canine Mammary Neoplasm, held on November 6th and 7th, 2010 in Belo Horizonte – MG, Brazil, sponsored by the Laboratory of Comparative Pathology – UFMG, with the support of the Brazilian Association of Veterinary Pathology (ABPV) and Brazilian Association of Veterinary Oncology (ABROVET). Academics from several regions of Brazil were present and contributed to this work.

Published
2011

134. Electroporation Transiently Decreases GJB2 (Connexin 26) Expression in B16/BL6 Melanoma Cell Line

Author

Rangel, Marcelo Monte Mór, primary, Chaible, Lucas Martins, additional, Nagamine, Marcia Kazumi, additional, Mennecier, Gregory, additional, Cogliati, Bruno, additional, de Oliveira, Krishna Duro, additional, Fukumasu, Heidge, additional, Sinhorini, Idércio Luiz, additional, Mir, Lluis Maria, additional, and Dagli, Maria Lúcia Zaidan, additional

Published
2014
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136. Genome-wide association analysis of feed intake and residual feed intake in Nellore cattle

Author

Santana, Miguel HA, primary, Utsunomiya, Yuri T, additional, Neves, Haroldo HR, additional, Gomes, Rodrigo C, additional, Garcia, José F, additional, Fukumasu, Heidge, additional, Silva, Saulo L, additional, Oliveira Junior, Gerson A, additional, Alexandre, Pâmela A, additional, Leme, Paulo R, additional, Brassaloti, Ricardo A, additional, Coutinho, Luiz L, additional, Lopes, Thiago G, additional, Meirelles, Flávio V, additional, Eler, Joanir P, additional, and Ferraz, José BS, additional

Published
2014
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140. Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle.

Author

Santana, Miguel, Junior, Gerson, Cesar, Aline, Freua, Mateus, Gomes, Rodrigo, Silva, Saulo, Leme, Paulo, Fukumasu, Heidge, Carvalho, Minos, Ventura, Ricardo, Coutinho, Luiz, Kadarmideen, Haja, and Ferraz, José

Abstract

The use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore ( Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid, and protein metabolism. The metabolic pathways found in this study are related to processes directly connected to feed efficiency in beef cattle. It was observed that, even though different genomic regions and genes were found between the two approaches (GWAS and CNV), the metabolic processes covered were related to each other. Therefore, a combination of the approaches complement each other and lead to a better understanding of the FCR. [ABSTRACT FROM AUTHOR]

Published
2016
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141. Genome-wide CNV analysis reveals variants associated with growth traits in Bos indicus.

Author

Yang Zhou, Utsunomiya, Yuri T., Lingyang Xu, El Hamidi abdel Hay, Bickhart, Derek M., Alexandre, Pamela Almeida, Rosen, Benjamin D., Schroeder, Steven G., Carvalheiro, Roberto, de Rezende Neves, Haroldo Henrique, Sonstegard, Tad S., Van Tassell, Curtis P., Ferraz, José Bento Sterman, Fukumasu, Heidge, Garcia, Jose Fernando, and Liu, George E.

Subjects
BIOLOGICAL variation, ZEBUS, SINGLE nucleotide polymorphisms, BEEF cattle, FALSE discovery rate
Abstract

Background: Apart from single nucleotide polymorphism (SNP), copy number variation (CNV) is another important type of genetic variation, which may affect growth traits and play key roles for the production of beef cattle. To date, no genome-wide association study (GWAS) for CNV and body traits in beef cattle has been reported, so the present study aimed to investigate this type of association in one of the most important cattle subspecies: Bos indicus (Nellore breed). Results: We have used intensity data from over 700,000 SNP probes across the bovine genome to detect common CNVs in a sample of 2230 Nellore cattle, and performed GWAS between the detected CNVs and nine growth traits. After filtering for frequency and length, a total of 231 CNVs ranging from 894 bp to 4,855,088 bp were kept and tested as predictors for each growth trait using linear regression analysis with principal components correction. There were 49 significant associations identified among 17 CNVs and seven body traits after false discovery rate correction (P < 0.05). Among the 17 CNVs, three were significant or marginally significant for all the traits. We have compared the locations of associated CNVs with quantitative trait locus and the RefGene database, and found two sets of 9 CNVs overlapping with either known QTLs or genes, respectively. The gene overlapping with CNV100, KCNJ12, is a functional candidate for muscle development and plays critical roles in muscling traits. Conclusion: This study presents the first CNV-based GWAS of growth traits using high density SNP microarray data in cattle. We detected 17 CNVs significantly associated with seven growth traits and one of them (CNV100) may be involved in growth traits through KCNJ12. [ABSTRACT FROM AUTHOR]

Published
2016
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142. Chronic exposure of lung alveolar epithelial type II cells to tobacco‐specific carcinogen NNK results in malignant transformation: A new in vitro lung carcinogenesis model

Author

Mennecier, Gregory, primary, Torres, Luciana N., additional, Cogliati, Bruno, additional, Sanches, Daniel S., additional, Mori, Claudia M., additional, Latorre, Andréia O., additional, Chaible, Lucas M., additional, Mackowiak, Ivone I., additional, Nagamine, Marcia K., additional, Da Silva, Tereza C., additional, Fukumasu, Heidge, additional, and Dagli, Maria Lucia Zaidan, additional

Published
2012
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146. Pfaffia paniculata (Brazilian ginseng) roots decrease proliferation and increase apoptosis but do not affect cell communication in murine hepatocarcinogenesis

Author

da Silva, Tereza Cristina, primary, Cogliati, Bruno, additional, da Silva, Ana Paula, additional, Fukumasu, Heidge, additional, Akisue, Gokithi, additional, Nagamine, Márcia Kazumi, additional, Matsuzaki, Patrícia, additional, Haraguchi, Mitsue, additional, Górniak, Silvana Lima, additional, and Dagli, Maria Lúcia Zaidan, additional

Published
2010
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