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101. Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

Author

Koenig, Michelle R., primary, Razo, Elaina, additional, Mitzey, Ann, additional, Newman, Christina M., additional, Dudley, Dawn M., additional, Breitbach, Meghan E., additional, Semler, Matthew R., additional, Stewart, Laurel M., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Bach, Kathryn M., additional, Mohns, Mariel S., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Fritsch, Michael, additional, Dennis, Maria, additional, Teixeira, Leandro B. C., additional, Schotzko, Michele L., additional, Nork, T. Michael, additional, Rasmussen, Carol A., additional, Katz, Alex, additional, Nair, Veena, additional, Hou, Jiancheng, additional, Hartman, Amy, additional, Ver Hoeve, James, additional, Kim, Charlene, additional, Schneider, Mary L., additional, Ausderau, Karla, additional, Kohn, Sarah, additional, Jaeger, Anna S., additional, Aliota, Matthew T., additional, Hayes, Jennifer M., additional, Schultz-Darken, Nancy, additional, Eickhoff, Jens, additional, Antony, Kathleen M., additional, Noguchi, Kevin, additional, Zeng, Xiankun, additional, Permar, Sallie, additional, Prabhakaran, Vivek, additional, Capuano, Saverio, additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, O’Connor, David H., additional, and Mohr, Emma L., additional

Published
2020
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103. Optimizing direct RT-LAMP to detect transmissible SARS-CoV-2 from primary nasopharyngeal swab and saliva patient samples

Author

Dudley, Dawn M., primary, Newman, Christina M., additional, Weiler, Andrea M., additional, Ramuta, Mitchell D., additional, Shortreed, Cecilia G., additional, Heffron, Anna S., additional, Accola, Molly A., additional, Rehrauer, William M., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2020
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105. Immunophenotyping of Rhesus CMV ‐Specific CD8 T‐Cell Populations

Author

Pomplun, Nicholas L., primary, Vosler, Logan, additional, Weisgrau, Kim L., additional, Furlott, Jessica, additional, Weiler, Andrea M., additional, Abdelaal, Hadia M., additional, Evans, David T., additional, Watkins, David I., additional, Matano, Tetsuro, additional, Skinner, Pamela J., additional, Friedrich, Thomas C., additional, and Rakasz, Eva G., additional

Published
2020
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107. Initial evaluation of a mobile SARS-CoV-2 RT-LAMP testing strategy

Author

Newman, Christina M., primary, Ramuta, Mitchell D., additional, McLaughlin, Matthew T., additional, Wiseman, Roger W., additional, Karl, Julie A., additional, Dudley, Dawn M., additional, Stauss, Miranda R., additional, Maddox, Robert J., additional, Weiler, Andrea M., additional, Bliss, Mason I., additional, Fauser, Katrina N., additional, Haddock, Luis A., additional, Shortreed, Cecilia G., additional, Haj, Amelia K., additional, Accola, Molly A., additional, Heffron, Anna S., additional, Bussan, Hailey E., additional, Reynolds, Matthew R., additional, Harwood, Olivia E., additional, Moriarty, Ryan V., additional, Stewart, Laurel M., additional, Crooks, Chelsea M., additional, Prall, Trent M., additional, Neumann, Emma K., additional, Somsen, Elizabeth D., additional, Burmeister, Corrie B., additional, Hall, Kristi L., additional, Rehrauer, William M., additional, Friedrich, Thomas C., additional, O’Connor, Shelby L., additional, and O’Connor, David H., additional

Published
2020
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108. Distinct patterns of SARS-CoV-2 transmission in two nearby communities in Wisconsin, USA

Author

Moreno, Gage K., primary, Braun, Katarina M., additional, Riemersma, Kasen K., additional, Martin, Michael A., additional, Halfmann, Peter J., additional, Crooks, Chelsea M, additional, Prall, Trent, additional, Baker, David, additional, Baczenas, John J., additional, Heffron, Anna S., additional, Ramuta, Mitchell, additional, Khubbar, Manjeet, additional, Weiler, Andrea M., additional, Accola, Molly A., additional, Rehrauer, William M, additional, O’Connor, Shelby L., additional, Safdar, Nasia, additional, Pepperell, Caitlin S., additional, Dasu, Trivikram, additional, Bhattacharyya, Sanjib, additional, Kawaoka, Yoshihiro, additional, Koelle, Katia, additional, O’Connor, David H., additional, and Friedrich, Thomas C., additional

Published
2020
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109. Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis)

Author

Finch, Courtney L., primary, Crozier, Ian, additional, Lee, Ji Hyun, additional, Byrum, Russ, additional, Cooper, Timothy K., additional, Liang, Janie, additional, Sharer, Kaleb, additional, Solomon, Jeffrey, additional, Sayre, Philip J., additional, Kocher, Gregory, additional, Bartos, Christopher, additional, Aiosa, Nina M., additional, Castro, Marcelo, additional, Larson, Peter A., additional, Adams, Ricky, additional, Beitzel, Brett, additional, Di Paola, Nicholas, additional, Kugelman, Jeffrey R., additional, Kurtz, Jonathan R., additional, Burdette, Tracey, additional, Nason, Martha C., additional, Feuerstein, Irwin M., additional, Palacios, Gustavo, additional, Claire, Marisa C. St., additional, Lackemeyer, Matthew G., additional, Johnson, Reed F., additional, Braun, Katarina M., additional, Ramuta, Mitchell D., additional, Wada, Jiro, additional, Schmaljohn, Connie S., additional, Friedrich, Thomas C., additional, O’Connor, David H., additional, and Kuhn, Jens H., additional

Published
2020
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112. Long-Term Protection of Rhesus Macaques from Zika Virus Reinfection

Author

Moreno, Gage K., primary, Newman, Christina M., additional, Koenig, Michelle R., additional, Mohns, Mariel S., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Weisgrau, Kim L., additional, Vosler, Logan J., additional, Pomplun, Nicholas, additional, Schultz-Darken, Nancy, additional, Rakasz, Eva, additional, Dudley, Dawn M., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2020
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114. Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia

Author

Moncla, Louise H., primary, Bedford, Trevor, additional, Dussart, Philippe, additional, Horm, Srey Viseth, additional, Rith, Sareth, additional, Buchy, Philippe, additional, Karlsson, Erik A., additional, Li, Lifeng, additional, Liu, Yongmei, additional, Zhu, Huachen, additional, Guan, Yi, additional, Friedrich, Thomas C., additional, and Horwood, Paul F., additional

Published
2020
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116. Pharyngeal motor cortex grey matter abnormalities and retinal photoreceptor layer dysfunction in macaques exposed to Zika virus in utero

Author

Koenig, Michelle R., Razo, Elaina, Mitzey, Ann, Semler, Matthew R., Stewart, Laurel M., Breitbach, Meghan E., Newman, Christina M., Dudley, Dawn M., Weiler, Andrea M., Rybarczyk, Sierra, Bach, Kathryn M., Mohns, Mariel S., Simmons, Heather A., Mejia, Andres, Dennis, Maria, Teixeira, Leandro B. C., Schotzko, Michele L., Nork, T. Michael, Rasmussen, Carol A., Katz, Alex, Hou, Jiancheng, Hartman, Amy, Ver Hoeve, James, Kim, Charlene, Schneider, Mary L., Ausderau, Karla, Kohn, Sarah, Jaeger, Anna S., Aliota, Matthew T., Salamat, M. Shahriar, Hayes, Jennifer M., Schultz-Darken, Nancy, Eickhoff, Jens, Antony, Kathleen M., Noguchi, Kevin, Zeng, Xiankun, Permar, Sallie, Ikonomidou, Chrysanthy, Prabhakaran, Vivek, Capuano III, Saverio, Friedrich, Thomas C., Golos, Thaddeus G., O’Connor, David H., and Mohr, Emma L.

Abstract

One third of infants who have prenatal Zika virus (ZIKV) exposure and lack significant defects consistent with congenital Zika syndrome (CZS) manifest neurodevelopmental deficits in their second year of life. We hypothesized that prenatal ZIKV exposure would lead to brain abnormalities and neurodevelopmental delays in infant macaques, as measured by quantitative hearing, neurodevelopmental, ocular and brain imaging studies. We inoculated 5 pregnant rhesus macaques with ZIKV during the first trimester, monitored pregnancies with serial ultrasounds, determined plasma viral RNA (vRNA) loads, and evaluated the infants for birth defects and neurodevelopmental deficits during their first week of life. ZIKV-exposed and control infants (n=16) were evaluated with neurobehavioral assessments, ophthalmic examinations, optical coherence tomography, electroretinography with visual evoked potentials, hearing examinations, magnetic resonance imaging (MRI) of the brain, gross post mortem examination, and histopathological and vRNA analyses of approximately 40 tissues and fluids. All 5 dams had ZIKV vRNA in plasma and seroconverted following ZIKV inoculation. One pregnancy resulted in a stillbirth. The ZIKV-exposed infants had decreased cumulative feeding volumes and weight gains compared with control infants, and also had grey matter abnormalities in the pharyngeal motor cortex identified by quantitative voxel-based morphometric comparisons. Quantitative ocular studies identified differences between ZIKV-exposed and control infants in retinal layer thicknesses and electroretinograms that were not identified in qualitative ophthalmic evaluations. Despite these findings of neuropathology, no ZIKV vRNA or IgM was detected in the infants. This suggests that ZIKV exposure without measurable vertical transmission can affect brain development in utero and that subtle neurodevelopmental delays may be detected with quantitative analyses in early infancy. Quantitative brain analyses, such as these, may predict neurodevelopmental delays that manifest later in childhood and allow early intervention and targeted therapies to improve functional outcomes of ZIKV exposed children. Author Summary Human infants with born to women with Zika virus infection during pregnancy are at risk for neurodevelopmental deficits later in childhood. We hypothesized that we could identify brain abnormalities associated with neurodevelopmental deficits in infant macaques exposed to Zika virus during pregnancy. We identified brain and retinal abnormalities in Zika virus-exposed infant macaques during their first week of life, which may be related to their findings of decreased feeding and slower weight gain. None of the infants had direct evidence of Zika virus infection in their tissues, body fluids or by detection of IgM antibodies. This suggests that Zika virus exposure during pregnancy can affect brain development in utero and that quantitative brain imaging analyses may predict neurodevelopmental delays. Early identification of Zika virus-exposed children at risk of neurodevelopmental deficits would promote targeted therapies in this population and improve the functional outcome of all Zika virus exposed children.

Published
2019
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117. Modeling Ebola virus persistence in human organoids

Author

Moreno, Gage, Buechler, Connor R., Braun, Katarina M., Semler, Matthew R., Baker, David A., Newman, Christina M., Kafetzopoulou, Liana E., Cornish, Joseph P., Chavez, Deborah, Guerra, Bernadette, Lanford, Robert, Brasky, Kathy, Kuhn, Jens H., Johnson, Reed F., Friedrich, Thomas C., Bailey, Adam Lee, and O’Connor, David H.

Published
2019
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119. Pre-existing SIV Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques

Author

Rodgers, Mark A., Ameel, Cassaundra, Ellis-Connell, Amy L., Balgeman, Alexis J., Maiello, Pauline, Barry, Gabrielle L., Friedrich, Thomas C., Klein, Edwin, O’Connor, Shelby L., and Scanga, Charles A.

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), is the leading cause of death among HIV positive patients. The precise mechanisms by which HIV impairs host resistance to a subsequent M.tb infection are unknown. We modeled this co-infection in Mauritian cynomolgus macaques (MCM) using SIV as an HIV surrogate. We infected seven MCM with SIVmac239 intrarectally and six months later co-infected them via bronchoscope with ~10 CFU M.tb . Another eight MCM were infected with M.tb alone. TB progression was monitored by clinical parameters, by culturing bacilli in gastric and bronchoalveolar lavages, and by serial 18 F-FDG PET/CT imaging. The eight MCM infected with M.tb alone displayed dichotomous susceptibility to TB, with four animals reaching humane endpoint within 13 weeks and four animals surviving >19 weeks post M.tb infection. In stark contrast, all seven SIV+ animals exhibited rapidly progressive TB following co-infection and all reached humane endpoint by 13 weeks. Serial PET/CT imaging confirmed dichotomous outcomes in MCM infected with M.tb alone and marked susceptibility to TB in all SIV+ MCM. Notably, imaging revealed a significant increase in TB granulomas between four and eight weeks post M.tb infection in SIV+, but not in SIV-naive MCM and implies that SIV impairs the ability of animals to contain M.tb dissemination. At necropsy, animals with pre-existing SIV infection had more extrapulmonary TB disease, more overall pathology, and increased bacterial loads than animals infected with M.tb alone. We thus developed a tractable MCM model in which to study SIV- M.tb co-infection and demonstrate that pre-existing SIV dramatically diminishes the ability to control M.tb co-infection. Author summary Mycobacterium tuberculosis ( M.tb ) is the etiologic agent of tuberculosis (TB) and infects a tremendous number of individuals. TB causes millions of deaths each year and is the leading cause of death in human immunodeficiency virus (HIV)-positive individuals. Currently, the mechanisms by which pre-existing HIV infection increases susceptibility to subsequent M.tb infection and predisposes an individual to TB disease are poorly understood. We developed a simian immunodeficiency virus (SIV) - M.tb co-infection model in Mauritian cynomolgus macaques (MCM) to investigate how SIV impairs the immune response to a subsequent M.tb infection. We show that naive MCM display variable resistance to TB while all SIV-infected MCM failed to control M.tb infection. Using quantitative measures of disease and serial PET/CT imaging, we show that SIV+ co-infected animals uniformly exhibit rapid TB progression, more tuberculosis disease dissemination, and increased mortality. This coinfection model will facilitate studies, provide unique insights into the defects underlying TB susceptibility in HIV+ individuals and will help us develop approaches to overcome these defects.

Published
2018
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122. Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

Author

Koenig, Michelle R., primary, Razo, Elaina, additional, Mitzey, Ann, additional, Newman, Christina M., additional, Dudley, Dawn M., additional, Breitbach, Meghan E., additional, Semler, Matthew R., additional, Stewart, Laurel M., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Bach, Kathryn M., additional, Mohns, Mariel S., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Fritsch, Michael, additional, Dennis, Maria, additional, Teixeira, Leandro B. C., additional, Schotzko, Michele L., additional, Nork, T. Michael, additional, Rasmussen, Carol A., additional, Katz, Alex, additional, Nair, Veena, additional, Hou, Jiancheng, additional, Hartman, Amy, additional, Hoeve, James Ver, additional, Kim, Charlene, additional, Schneider, Mary L., additional, Ausderau, Karla, additional, Kohn, Sarah, additional, Jaeger, Anna S., additional, Aliota, Matthew T., additional, Hayes, Jennifer M., additional, Schultz-Darken, Nancy, additional, Eickhoff, Jens, additional, Antony, Kathleen M., additional, Noguchi, Kevin, additional, Zeng, Xiankun, additional, Permar, Sallie, additional, Prabhakaran, Vivek, additional, Capuano, Saverio, additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, O’Connor, David H., additional, and Mohr, Emma L., additional

Published
2019
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123. CD8β Depletion Does Not Prevent Control of Viral Replication or Protection from Challenge in Macaques Chronically Infected with a Live Attenuated Simian Immunodeficiency Virus

Author

Sutton, Matthew S., primary, Ellis-Connell, Amy, additional, Balgeman, Alexis J., additional, Barry, Gabrielle, additional, Weiler, Andrea M., additional, Hetzel, Scott J., additional, Zhou, Yan, additional, Lau-Kilby, Annie W., additional, Mason, Rosemarie D., additional, Biris, Kristin K., additional, Mascola, John R., additional, Sullivan, Nancy J., additional, Roederer, Mario, additional, Friedrich, Thomas C., additional, and O’Connor, Shelby L., additional

Published
2019
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124. Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques

Author

Breitbach, Meghan E., primary, Newman, Christina M., additional, Dudley, Dawn M., additional, Stewart, Laurel M., additional, Aliota, Matthew T., additional, Koenig, Michelle R., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Crooks, Chelsea M., additional, Young, Ginger, additional, Semler, Matthew R., additional, Weiler, Andrea M., additional, Barry, Gabrielle L., additional, Heimsath, Holly, additional, Mohr, Emma L., additional, Eichkoff, Jens, additional, Newton, Wendy, additional, Peterson, Eric, additional, Schultz-Darken, Nancy, additional, Permar, Sallie R., additional, Dean, Hansi, additional, Capuano, Saverio, additional, Osorio, Jorge E., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2019
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125. Long-term protection of rhesus macaques from Zika virus reinfection

Author

Moreno, Gage K., primary, Newman, Christina M., additional, Koenig, Michelle R., additional, Mohns, Mariel S., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Vosler, Logan J., additional, Pomplun, Nicholas, additional, Schultz-Darken, Nancy, additional, Rakasz, Eva, additional, Dudley, Dawn M., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2019
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126. Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia

Author

Moncla, Louise H., primary, Bedford, Trevor, additional, Dussart, Philippe, additional, Horm, Srey Viseth, additional, Rith, Sareth, additional, Buchy, Philippe, additional, Karlsson, Erik A, additional, Li, Lifeng, additional, Liu, Yongmei, additional, Zhu, Huachen, additional, Guan, Yi, additional, Friedrich, Thomas C., additional, and Horwood, Paul F., additional

Published
2019
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127. Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission

Author

Jaeger, Anna S., primary, Murrieta, Reyes A., additional, Goren, Lea R., additional, Crooks, Chelsea M., additional, Moriarty, Ryan V., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Semler, Matthew R., additional, Huffman, Christopher, additional, Mejia, Andres, additional, Simmons, Heather A., additional, Fritsch, Michael, additional, Osorio, Jorge E., additional, Eickhoff, Jens C., additional, O’Connor, Shelby L., additional, Ebel, Gregory D., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2019
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128. Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus

Author

Sutton, Matthew S., primary, Ellis-Connell, Amy, additional, Balgeman, Alexis J., additional, Barry, Gabrielle, additional, Weiler, Andrea M., additional, Hetzel, Scott J., additional, Zhou, Yan, additional, Kilby, Annie, additional, Mason, Rosemarie D., additional, Biris, Kristin K., additional, Mascola, John R., additional, Sullivan, Nancy J., additional, Roederer, Mario, additional, Friedrich, Thomas C., additional, and O’Connor, Shelby L., additional

Published
2019
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131. Preexisting Simian Immunodeficiency Virus Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques

Author

Rodgers, Mark A., primary, Ameel, Cassaundra, additional, Ellis-Connell, Amy L., additional, Balgeman, Alexis J., additional, Maiello, Pauline, additional, Barry, Gabrielle L., additional, Friedrich, Thomas C., additional, Klein, Edwin, additional, O’Connor, Shelby L., additional, and Scanga, Charles A., additional

Published
2018
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133. Immunophenotyping of Rhesus CMV‐Specific CD8 T‐Cell Populations.

Author

Pomplun, Nicholas L., Vosler, Logan, Weisgrau, Kim L., Furlott, Jessica, Weiler, Andrea M., Abdelaal, Hadia M., Evans, David T., Watkins, David I., Matano, Tetsuro, Skinner, Pamela J., Friedrich, Thomas C., and Rakasz, Eva G.

Abstract

A vaccine to ameliorate cytomegalovirus (CMV)‐related pathogenicity in transplantation patients is considered a top priority. A therapeutic vaccine must include components that elicit both neutralizing antibodies, and highly effective CD8 T‐cell responses. The most important translational model of vaccine development is the captive‐bred rhesus macaque (Macaca mulatta) of Indian origin. There is a dearth of information on rhesus cytomegalovirus (rhCMV)‐specific CD8 T cells due to the absence of well‐defined CD8 T‐cell epitopes presented by classical MHC‐I molecules. In the current study, we defined two CD8 T‐cell epitopes restricted by high‐frequency Mamu alleles: the Mamu‐A1*002:01 restricted VY9 (VTTLGMALY aa291‐299) epitope of protein IE‐1, and the Mamu‐A1*008:01 restricted NP8 (NPTDRPIP aa96‐103) epitope of protein phosphoprotein 65‐2. We developed tetramers and determined the level, phenotype, and functional capability of the two epitope‐specific T‐cell populations in circulation and various tissues. We demonstrated the value of these tetramers for in situ tetramer staining. Here, we first provided critical reagents and established a flow cytometric staining strategy to study rhCMV‐specific T‐cell responses in up to 40% of captive‐bred rhesus macaques. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals LLC on behalf of International Society for Advancement of Cytometry. [ABSTRACT FROM AUTHOR]

Published
2021
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134. Effect of Previous-Season Influenza Vaccination on Serologic Response in Children During 3 Seasons, 2013–2014 Through 2015–2016.

Author

McLean, Huong Q, King, Jennifer P, Talley, Pamela, Flannery, Brendan, Spencer, Sarah, Levine, Min Z, Friedrich, Thomas C, and Belongia, Edward A

Subjects
HEMAGGLUTINATION tests, INFLUENZA vaccines, SEASONS, VIRAL antibodies, VIRAL antigens, SEASONAL influenza, ANTIBODY formation, CHILDREN
Abstract

Background The effects of repeated influenza vaccination in children are not well understood. In this study, we evaluated previous vaccination effects on antibody response after vaccination with trivalent inactivated influenza vaccine (IIV) or quadrivalent live-attenuated influenza vaccine (LAIV) among school-aged children (5–17 years) across 3 seasons. Methods Children were enrolled in the fall of 2013, 2014, and 2015. The participants received IIV or LAIV according to parent preference (2013–2014) or our randomization scheme (2014–2015). All study children received IIV in 2015–2016. Hemagglutination-inhibition assays measured antibody response to egg-grown vaccine strains from prevaccination and postvaccination serum samples. Geometric mean titers (GMTs) and increases in GMTs from before to after vaccination (geometric mean fold rise [GMFR]) were estimated from repeated-measures linear mixed models. Results We enrolled 161 children in 2013–2014, 128 in 2014–2015, and 126 in 2015–2016. Among the IIV recipients, responses to the influenza A(H1N1)pdm09 and B vaccine strains were lowest among children who had received a previous-season IIV. The GMFRs for strains A(H1N1)pdm09 and B were 1.5 to 2.3 for previous-season IIV and 4.3 to 12.9 for previous-season LAIV or no previous vaccine. GMFRs were lower for strain A(H3N2), and differences according to previous-season vaccination history were smaller and not significant in most seasons. Most children had a post-IIV vaccination titer of ≥40 for vaccine strains in all seasons, regardless of previous-season vaccination history. Little to no increase in antibody levels was observed after vaccination with LAIV. Conclusions Serologic response to vaccination was greatest for IIV, but previous-season vaccination modified IIV response to A(H1N1)pdm09 and B. Influenza A(H3N2) responses were low in all groups, and LAIV generated minimal serologic response against all strains. [ABSTRACT FROM AUTHOR]

Published
2020
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135. Zika viruses of both African and Asian lineages cause fetal harm in a vertical transmission model

Author

Jaeger, Anna S., primary, Murreita, Reyes A., additional, Goren, Lea R., additional, Crooks, Chelsea M., additional, Moriarty, Ryan V., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Semler, Matthew R., additional, Huffman, Christopher, additional, Mejia, Andres, additional, Simmons, Heather A., additional, Fritsch, Michael, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, Ebel, Gregory D., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2018
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138. Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010

Author

Imai, Hirotaka, primary, Dinis, Jorge M., additional, Zhong, Gongxun, additional, Moncla, Louise H., additional, Lopes, Tiago J.S., additional, McBride, Ryan, additional, Thompson, Andrew J., additional, Peng, Wenjie, additional, Le, Mai thi Q., additional, Hanson, Anthony, additional, Lauck, Michael, additional, Sakai-Tagawa, Yuko, additional, Yamada, Shinya, additional, Eggenberger, Julie, additional, O’Connor, David H., additional, Suzuki, Yasuo, additional, Hatta, Masato, additional, Paulson, James C., additional, Neumann, Gabriele, additional, Friedrich, Thomas C., additional, and Kawaoka, Yoshihiro, additional

Published
2018
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140. Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

Author

Aliota, Matthew T., primary, Dudley, Dawn M., additional, Newman, Christina M., additional, Weger-Lucarelli, James, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Breitbach, Meghan E., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Haj, Amelia K., additional, Moriarty, Ryan V., additional, Mohns, Mariel S., additional, Mohr, Emma L., additional, Venturi, Vanessa, additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Schotzko, Michele L., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Hayes, Jennifer M., additional, Capuano, Saverio, additional, Davenport, Miles P., additional, Friedrich, Thomas C., additional, Ebel, Gregory D., additional, O’Connor, Shelby L., additional, and O’Connor, David H., additional

Published
2018
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141. Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses

Author

Schouest, Blake, primary, Weiler, Andrea M., additional, Janaka, Sanath Kumar, additional, Myers, Tereance A., additional, Das, Arpita, additional, Wilder, Sarah C., additional, Furlott, Jessica, additional, Baddoo, Melody, additional, Flemington, Erik K., additional, Rakasz, Eva G., additional, Evans, David T., additional, Friedrich, Thomas C., additional, and Maness, Nicholas J., additional

Published
2018
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142. Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection

Author

Mohr, Emma L., primary, Block, Lindsey N., additional, Newman, Christina M., additional, Stewart, Laurel M., additional, Koenig, Michelle, additional, Semler, Matthew, additional, Breitbach, Meghan E., additional, Teixeira, Leandro B. C., additional, Zeng, Xiankun, additional, Weiler, Andrea M., additional, Barry, Gabrielle L., additional, Thoong, Troy H., additional, Wiepz, Gregory J., additional, Dudley, Dawn M., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Morgan, Terry K., additional, Salamat, M. Shahriar, additional, Kohn, Sarah, additional, Antony, Kathleen M., additional, Aliota, Matthew T., additional, Mohns, Mariel S., additional, Hayes, Jennifer M., additional, Schultz-Darken, Nancy, additional, Schotzko, Michele L., additional, Peterson, Eric, additional, Capuano, Saverio, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, Friedrich, Thomas C., additional, O’Connor, David H., additional, and Golos, Thaddeus G., additional

Published
2018
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143. Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Author

Dudley, Dawn M., primary, Newman, Christina M., additional, Lalli, Joseph, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Mohns, Mariel S., additional, Breitbach, Meghan E., additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Mohr, Emma L., additional, Capuano III, Saverio, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, O’Connor, David H., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2017
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145. Molecularly barcoded Zika virus libraries to probein vivoevolutionary dynamics

Author

Aliota, Matthew T., primary, Dudley, Dawn M., additional, Newman, Christina M., additional, Weger-Lucarelli, James, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Breitbach, Meghan E., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Mohns, Mariel S., additional, Mohr, Emma L., additional, Venturi, Vanessa, additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Schotzko, Michele L., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Hayes, Jennifer M., additional, Capuano, Saverio, additional, Davenport, Miles P., additional, Friedrich, Thomas C., additional, Ebel, Gregory D., additional, O’Connor, Shelby L., additional, and O’Connor, David H., additional

Published
2017
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146. Viral factors in influenza pandemic risk assessment

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Raman, Rahul, Lipsitch, Marc, Barclay, Wendy, Russell, Charles J, Belser, Jessica A, Cobey, Sarah, Kasson, Peter M, Lloyd-Smith, James O, Maurer-Stroh, Sebastian, Riley, Steven, Beauchemin, Catherine AA, Bedford, Trevor, Friedrich, Thomas C, Handel, Andreas, Herfst, Sander, Murcia, Pablo R, Roche, Benjamin, Wilke, Claus O, Russell, Colin A, Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Raman, Rahul, Lipsitch, Marc, Barclay, Wendy, Russell, Charles J, Belser, Jessica A, Cobey, Sarah, Kasson, Peter M, Lloyd-Smith, James O, Maurer-Stroh, Sebastian, Riley, Steven, Beauchemin, Catherine AA, Bedford, Trevor, Friedrich, Thomas C, Handel, Andreas, Herfst, Sander, Murcia, Pablo R, Roche, Benjamin, Wilke, Claus O, and Russell, Colin A

Abstract

The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk.

Published
2017

147. Ocular and uteroplacental pathology in macaque congenital Zika virus infection

Author

Mohr, Emma L., primary, Block, Lindsey N., additional, Newman, Christina M., additional, Stewart, Laurel M., additional, Koenig, Michelle, additional, Semler, Matthew, additional, Breitbach, Meghan E., additional, Teixeira, Leandro B.C., additional, Zeng, Xiankun, additional, Weiler, Andrea M., additional, Barry, Gabrielle L., additional, Thoong, Troy H., additional, Wiepz, Gregory J., additional, Dudley, Dawn M., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Morgan, Terry K., additional, Shahriar Salamat, M., additional, Kohn, Sarah, additional, Antony, Kathleen M., additional, Aliota, Matthew T., additional, Mohns, Mariel S., additional, Hayes, Jennifer M., additional, Schultz-Darken, Nancy, additional, Schotzko, Michele L., additional, Peterson, Eric, additional, Capuano, Saverio, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, Friedrich, Thomas C., additional, O’Connor, David H., additional, and Golos, Thaddeus G., additional

Published
2017
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148. Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

Author

Dudley, Dawn M., primary, Newman, Christina M., additional, Lalli, Joseph, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Mohns, Mariel S., additional, Breitbach, Meghan E., additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Mohr, Emma L., additional, Capuano, Saverio, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, O’Connor, David H., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2017
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