273 results on '"Franke, Axel"'
Search Results
102. Near Wall Combustion in a Homogenous Charge Compression Ignition (HCCI) Engine
- Author
-
Hultqvist, Anders, Johansson, Bengt, Christensen, Magnus, Richter, Mattias, Engström, Johan, Franke, Axel, Hultqvist, Anders, Johansson, Bengt, Christensen, Magnus, Richter, Mattias, Engström, Johan, and Franke, Axel
- Abstract
NR 20151123
- Published
- 2000
103. Optical Diagnostics Applied to a Naturally Aspirated Homogeneous Charge Compression Ignition Engine
- Author
-
Richter, Mattias, Franke, Axel, Alden, Marcus, Hultqvist, Anders, Johansson, Bengt, Richter, Mattias, Franke, Axel, Alden, Marcus, Hultqvist, Anders, and Johansson, Bengt
- Abstract
Basic optical properties have been investigated in order to characterize the HCCI-combustion process. Basic optical properties of a Homogeneous Charge Compression Ignition (HCCI) engine have been investigated in order to characterize the combustion process. The absorption of light propagating through the combustion chamber has been spectrally resolved for four different fuels. Significant differences between the fuels could be detected. Complementary information could be obtained by recording spontaneous emission of radiation during combustion. Raman point measurements were used to quantify cycle-to-cycle variations of the equivalence ratio. The homogeneity of the charge was monitored by the use of two-dimensional tracer LIF. That method was also utilized to investigate the flame development. The experiments were performed in a six-cylinder, truck-sized engine with one cylinder modified to allow for optical access. The results obtained are believed to be valuable in future applications of optical diagnostics in similar environments., QC 20151124
- Published
- 1999
- Full Text
- View/download PDF
104. In Vitro Restoration of Post-Operatively Decreased IFN-Gamma Levels After Cardiac Surgery and Its Effect on Pro- and Anti-Inflammatory Mediators
- Author
-
Franke, Axel, primary, Lante, Wolfgang, additional, Markewitz, Andreas, additional, and Weinhold, Christian, additional
- Published
- 2006
- Full Text
- View/download PDF
105. Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know?
- Author
-
Franke, Axel, primary, Lante, Wolfgang, additional, Fackeldey, Volker, additional, Becker, Horst P., additional, Kurig, Edmond, additional, Zöller, Lothar G., additional, Weinhold, Christian, additional, and Markewitz, Andreas, additional
- Published
- 2005
- Full Text
- View/download PDF
106. Physical Fitness after Apical Resection for the Treatment of Primary Spontaneous Pneumothorax
- Author
-
Fackeldey, Volker, primary, Franke, Axel, additional, Schachtrupp, Alexander, additional, Becker, H. Peter, additional, and Schwab, Robert, additional
- Published
- 2005
- Full Text
- View/download PDF
107. Reply
- Author
-
Franke, Axel, primary, Lante, Wolfgang, additional, and Markewitz, Andreas, additional
- Published
- 2003
- Full Text
- View/download PDF
108. The Effect of In-Cylinder Gas Flow on the Interpretation of the Ionization Sensor Signal
- Author
-
Franke, Axel, primary, Einewall, Patrik, additional, Johansson, Bengt, additional, Wickström, Nicholas, additional, Reinmann, Raymond, additional, and Larsson, Anders, additional
- Published
- 2003
- Full Text
- View/download PDF
109. Analysis of the Ionization Equilibrium in the Post-Flame Zone
- Author
-
Franke, Axel, primary, Einewall, Patrik, additional, Reinmann, Raymond, additional, and Larsson, Anders, additional
- Published
- 2003
- Full Text
- View/download PDF
110. Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times
- Author
-
Franke, Axel, primary, Lante, Wolfgang, additional, Fackeldey, Volker, additional, Becker, Horst Peter, additional, Thode, Christian, additional, Kuhlmann, Wolf Dieter, additional, and Markewitz, Andreas, additional
- Published
- 2002
- Full Text
- View/download PDF
111. Creating Virtual Prototypes of Complex MEMS Transducers Using Reduced-Order Modelling Methods and VHDL-AMS.
- Author
-
Vachoux, A., Mähne, Torsten, Kehr, Kersten, Franke, Axel, Hauer, Jörg, and Schmidt, Bertram
- Published
- 2006
- Full Text
- View/download PDF
112. Employing an Ionization Sensor for Combustion Diagnostics in a Lean Burn Natural Gas Engine
- Author
-
Franke, Axel, primary, Einewall, Patrik, additional, Johansson, Bengt, additional, and Reinmann, Raymond, additional
- Published
- 2001
- Full Text
- View/download PDF
113. ALTERATIONS OF CELL-MEDIATED IMMUNITY FOLLOWING CARDIAC OPERATIONS: CLINICAL IMPLICATIONS AND OPEN QUESTIONS
- Author
-
Markewitz, Andreas, primary, Lante, Wolfgang, additional, Franke, Axel, additional, Marohl, Klaus, additional, Kuhlmann, Wolf Dieter, additional, and Weinhold, Christian, additional
- Published
- 2001
- Full Text
- View/download PDF
114. Dosage compensation rox!
- Author
-
Franke, Axel, primary and Baker, Bruce S, additional
- Published
- 2000
- Full Text
- View/download PDF
115. Calorimetric Characterization of Commercial Ignition Systems
- Author
-
Franke, Axel, primary and Reinmann, Raymond, additional
- Published
- 2000
- Full Text
- View/download PDF
116. A Study of the Homogeneous Charge Compression Ignition Combustion Process by Chemiluminescence Imaging
- Author
-
Anders, Hultqvist, primary, Christensen, Magnus, additional, Johansson, Bengt, additional, Franke, Axel, additional, Richter, Mattias, additional, and Aldén, Marcus, additional
- Published
- 1999
- Full Text
- View/download PDF
117. The rox1 and rox2 RNAs Are Essential Components of the Compensasome, which Mediates Dosage Compensation in Drosophila
- Author
-
Franke, Axel, primary and Baker, Bruce S, additional
- Published
- 1999
- Full Text
- View/download PDF
118. Spectroscopic studies of luminescent and ionically conducting Eu[N(CF3SO2)2]3-PPG4000 complexes
- Author
-
Ferry, Anders, primary, Furlani, Maurizio, additional, Franke, Axel, additional, Jacobsson, Per, additional, and Mellander, Bengt-Erik, additional
- Published
- 1998
- Full Text
- View/download PDF
119. Mechanisms of heritable gene silencing during Drosophila development
- Author
-
Franke, Axel, primary, Messmer, Sabine, additional, Möhrle, Axel, additional, Orlando, Valerio, additional, Zink, Daniele, additional, and Paro, Renato, additional
- Published
- 1994
- Full Text
- View/download PDF
120. Metal island films near the surface of optical coatings: deposition experiments and plasmon-absorption line adjustment of metal nanoclusters in organic and inorganic optical thin films.
- Author
-
Stenzel, Olaf, Stendal, Alexander, Roeder, Michael, Lebedev, Andrei, Franke, Axel, and von Borczyskowski, Christian
- Published
- 1997
- Full Text
- View/download PDF
121. EXOGENOUS IL-12 AND ITS EFFECT ON TH1/TH2 CELL ACTIVITY AFTER CARDIAC SURGERY.
- Author
-
Franke, Axel, Lante, Wolfgang, Kollig, Erwin, Koeller, Manfred, Schinkel, Christian, and Markewitz, Andreas
- Published
- 2009
- Full Text
- View/download PDF
122. Terror preparedness as a service of general interest: the Terror and Disaster Surgical Care (TDSC®)-course.
- Author
-
Achatz, Gerhard, Bieler, Dan, Franke, Axel, and Friemert, Benedikt
- Subjects
EDUCATION of surgeons ,DISASTERS ,EMERGENCY medical services ,MASS casualties ,PENETRATING wounds ,SERIAL publications ,TERRORISM ,PERIOPERATIVE care - Abstract
An editorial is presented on the threat of terror in Europe is ever present, and the number of attacks worldwide is unfortunately increasing, this means that must prepare health systems and the corresponding care facilities for treating the victims of such attacks. The article discusses that the Terror and Disaster Surgical Care (TDSC®)-course is designed to address this challenge, and the course was developed and implemented on the basis of an initiative launched in 2016.
- Published
- 2020
- Full Text
- View/download PDF
123. Hyporesponsiveness of T cell subsets after cardiac surgery: a product of altered cell function or merely a result of absolute cell count changes in peripheral blood?
- Author
-
Franke, Axel, Lante, Wolfgang, Kurig, Edmond, Zöller, Lothar G., Weinhold, Christian, and Markewitz, Andreas
- Subjects
- *
CARDIAC surgery , *T cells , *LYMPHOCYTES , *LEUCOCYTES - Abstract
Abstract: Objective: The activity of the specific immune system and especially the function of T helper (TH) cells are reduced after cardiac surgery. This decrease is followed by an increase in TH2 cell activity and a delayed recovery of TH1 cell function (TH1/TH2 shift). Neither the underlying cause nor the relationship between the absolute numbers of T lymphocyte subpopulations, the state of activation of these cells and cytokine synthesis in cell culture has been clarified. We conducted a prospective study in order to test the hypothesis that the decrease in specific immunity is not caused by dilution effects but by functional alterations in T cell subsets. Methods: Blood samples were obtained from 40 patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB) preoperatively (d0), immediately after surgery (dx), and on the 1st (d1), 3rd (d3) and 5th (d5) postoperative days. The samples were stimulated for 24h with staphylococcal enterotoxin B and lipopolysaccharide. Interferon (IFN)-gamma, interleukin (IL)-2, IL-4, and IL-5 concentrations were measured by flow cytometry using a cytokine bead array kit. We determined white blood cell counts, analysed lymphocyte populations, and assayed human leukocyte antigen (HLA)-DR expression on cluster of differentiation (CD)4+ and CD8+ lymphocytes. Cytokine concentrations were corrected to preoperative absolute numbers of T helper cells. Results: Leukocyte counts were elevated during the entire postoperative course with a maximum on dx. Absolute lymphocyte counts and especially the T cell subpopulations significantly increased immediately after surgery, then decreased to a minimum on d1 and increased again until they returned to preoperative levels on d3. The release of IFN-gamma, IL-2 and IL-4 was significantly reduced from dx to d5 with a minimum on d1. IL-5 was significantly reduced on dx and d1. When the concentrations were corrected to preoperative TH lymphocyte levels, IL-2 and IL-5 synthesis was significantly reduced only on dx and IL-4 release only on dx and d1. By contrast, IFN-gamma synthesis decreased postoperatively and remained suppressed until d5 with a minimum on d1. Only on d1 did an increase in HLA-DR expression give evidence of a change in the state of TH cell activation. Conclusions: The number of immune cells of the specific and the non-specific immune system is not reduced in the immediate postoperative period. Haemodilution thus has no detectable effect on immune function at this time point. Beginning on d1, the function of specific immune cells, especially TH lymphocytes, is severely suppressed. This functional alteration appears not to be preceded by T cell activation during CPB. Although TH cell activity begins to increase on d1, cytokine synthesis is reduced. When cytokine synthesis is corrected to the absolute number of TH cells in culture, there is strong evidence for an increase in TH2 cell activity. On the whole, these results corroborate the hypothesis of a TH1/TH2 shift that is primarily caused by an alteration of TH1 function. Neither haemodilution nor a preceding activation plays a major role. [Copyright &y& Elsevier]
- Published
- 2006
- Full Text
- View/download PDF
124. Is Interferon Gamma Suppression After Cardiac Surgery Caused by a Decreased Interleukin-12 Synthesis?
- Author
-
Franke, Axel, Lante, Wolfgang, Kurig, Edmond, Zöller, Lothar G., Weinhold, Christian, and Markewitz, Andreas
- Subjects
INTERFERONS ,CARDIAC surgery patients ,ANTIVIRAL agents ,INTERLEUKIN-12 - Abstract
Background: The suppression of interferon gamma (IFN-gamma) synthesis after cardiac surgery is discussed as a cause of postoperative immunosuppression that predisposes to postoperative infectious complications. Because several studies have suggested that interleukin-12 (IL-12) production by monocytes and macrophages is reduced after cardiac surgery, this might cause a decrease in IFN-gamma release. To better understand these processes, we assessed the role of IL-12 in IFN-gamma synthesis in vitro before and after cardiac surgery. Methods: Heparinized whole blood samples were obtained from 20 patients undergoing elective cardiac surgery preoperatively (day 0) and on the first (day 1), third (day 3), and fifth (day 5) postoperative days, and stimulated (24 hours) with staphylococcal enterotoxin B and lipopolysaccharide. Recombinant IL-12 was added at each time point investigated. Interferon-gamma, IL-12, IL-2, IL-4, and IL-5 concentrations and histocompatibility leukocyte antigen-DR (HLA-DR) expression on monocytes and macrophages were assayed by flow cytometry. Results: The HLA-DR expression, IL-12 release, and IFN-gamma synthesis were significantly reduced on day 1, day 3, and day 5. Recovery began on day 3. Interleukin-12 caused a significant increase in IFN-gamma synthesis at each time point. When IL-12 was added, IFN-gamma synthesis returned to preoperative levels on days 3 and 5. Conclusions: The synthesis of IFN-gamma is significantly reduced after cardiac surgery. The application of IL-12 causes an increase in IFN-gamma synthesis before surgery and a return of IFN-gamma to preoperative levels within a few days after surgery. These findings suggest that postoperative suppression of IFN-gamma release is caused by a decrease in IL-12 synthesis. In addition, IL-12 has a mainly proinflammatory effect both before and after surgery. [Copyright &y& Elsevier]
- Published
- 2006
- Full Text
- View/download PDF
125. Delayed recovery of human leukocyte antigen-DR expression after cardiac surgery with early non-lethal postoperative complications: only an epiphenomenon?
- Author
-
Franke, Axel, Lante, Wolfgang, Zoeller, Lothar G, Kurig, Edmund, Weinhold, Christian, and Markewitz, Andreas
- Abstract
HLA-DR expression on peripheral blood monocytes is reduced after cardiac surgery. Little is known about the reconstitution of HLA-DR expression on peripheral blood monocytes in patients suffering from early non-fatal perioperative complications. We conducted a prospective study to prove whether these complications adversely affect the recovery of HLA-DR expression. Before surgery (d0), on the first (d1), third (d3), fifth (5th) postoperative days, blood samples were collected from 90 patients who underwent elective cardiac surgery with cardiopulmonary bypass (CPB). HLA-DR expression was analysed flow cytometrically. Eleven patients experienced postoperative complications [mechanical ventilation of 24-48 h (n=6); reinstitution of CPB (n=2) intraoperatively; laparotomy (n=1), re-thoracotomy (n=1), re-intubation (n=1) within the first 24 h after surgery]. All patients showed a reduced HLA-DR expression after surgery with nadirs at d1 and d3. Whereas the values increased from d3 to d5 in patients with an uneventful clinical course, HLA-DR expression remained suppressed in patients with complications. HLA-DR expression is reduced after cardiac surgery with CPB. A delayed recovery of HLA-DR expression is seen in patients with early perioperative complications. These non-fatal complications appear to represent a 'second hit' resulting in a prolonged deficiency of the innate immune system. This might predispose to further infectious and septic complications.
- Published
- 2008
- Full Text
- View/download PDF
126. ALTERATIONS OF CELLMEDIATED IMMUNITY FOLLOWING CARDIAC OPERATIONS CLINICAL IMPLICATIONS AND OPEN QUESTIONS
- Author
-
Markewitz, Andreas, Lante, Wolfgang, Franke, Axel, Marohl, Klaus, Kuhlmann, Wolf Dieter, and Weinhold, Christian
- Abstract
Cardiac surgery with cardiopulmonary bypass CPB is known to induce an immune response whose nature has been increasingly elucidated during the recent decade. Clinically, patients usually show two to three of the four symptoms, which define the socalled systemic inflammatory response syndrome SIRS. In addition, all parameters of the innate, nonspecific immune system, e.g., polymorphonuclear cells, elastase, and complement, are activated. This also applies to the proinflammatory mediators interleukin IL1, 6, and 8, and tumor necrosis factor TNF. Within the adaptive, specific immune system, a decrease of T lymphocytes and T helper TH cells is observed, whereas suppressor cytotoxic T cells and B cells appear to be nearly unaffected. Cytokine measurements provide more detailed information IL2 and IL12, which are important for the activation of the type1 THcell TH1mediated immune response, are depressed following cardiac operation. In contrast, IL10 and transforming growth factor essential to TH2mediated humoral or antiinflammatory immune response, are upregulated. In vivotests, e.g., delayed type hypersensitivity skin reaction and tetanus antibody production, confirm the polarization of the adaptive immune response towards the TH2 pathway. However, all these alterations usually do not result in clinical adverse events. Therefore, more information is needed about the immune response of patients at high preoperative risk or with serious perioperative complications to find out whether clinically relevant events are correlated to alterations of immune response. For this purpose, more readily available, standardized methods for immunologic monitoring appear highly desirable.
- Published
- 2001
127. Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila
- Author
-
Gorman, Monica, Franke, Axel, and Baker, Bruce S.
- Abstract
In Drosophila, dosage compensation occurs by transcribing the single male X chromosome at twice the rate of each of the two female X chromosomes. This hypertranscription requires four autosomal male-specific lethal(msl) genes and is negatively regulated by the Sxl gene in females. Two of the msls, the mle and msl-1 genes, encode proteins that are associated with hundreds of specific sites along the length of the male X chromosome. MLE and MSL-1 X chromosome binding are negatively regulated by Sxl in females and require the functions of the other msls in males. To investigate further the regulation of dosage compensation and the role of the msls in this process, we have cloned and molecularly characterized another msl, the msl-3 gene. We have found that MSL-3 is also associated with the male X chromosome. We have further investigated whether Sxl negatively regulates MSL-3 X-chromosome binding in females and whether MSL-3 X-chromosome binding requires the other msls. Our results suggest that the MLE, MSL-1 and MSL-3 proteins may associate with one another in a male-specific heteromeric complex on the X chromosome to achieve its hypertranscription.
- Published
- 1995
- Full Text
- View/download PDF
128. Evidence that MSL-mediated dosage compensation in Drosophila begins at blastoderm
- Author
-
Franke, Axel, Dernburg, Abby, Bashaw, Greg J., and Baker, Bruce S.
- Abstract
In Drosophila equalization of the amounts of gene products produced by X-linked genes in the two sexes is achieved by hypertranscription of the single male X chromosome. This process, dosage compensation, is controlled by a set of male-specific lethal (msl) genes, that appear to act at the level of chromatin structure. The properties of the MSL proteins have been extensively studied in the polytene salivary gland chromosomes where they bind to the same set of sites along the male X chromosome in a co-dependent manner. Here we report experiments that show that the MSL proteins first associate with the male X chromosome as early as blastoderm stage, slightly earlier than the histone H4 isoform acetylated at lysine 16 is detected on the X chromosome. MSL binding to the male X chromosome is observed in all somatic tissues of embryos and larvae. Binding of the MSLs to the X chromosome is also interdependent in male embryos and prevented in female embryos by the expression of Sex-lethal (Sxl). A delayed onset of binding of the MSLs in male progeny of homozygous mutant msl-1 or mle mothers coupled with the previous finding that such males have an earlier lethal phase supports the idea that msl-mediated dosage compensation begins early in embryogenesis. Other results show that the maleless (MLE) protein on embryo and larval chromosomes differs in its reactivity with antibodies; the functional significance of this finding remains to be explored.
- Published
- 1996
- Full Text
- View/download PDF
129. Creating Virtual Prototypes of Complex Micro-Electro-Mechanical Transducers Using Reduced-Order Modelling Methods and VHDL-AMS
- Author
-
Mähne, Torsten, Kehr, Kersten, Franke, Axel, Hauer, Jörg, Schmidt, Bertram, and Vachoux, Alain
- Subjects
surface micromachined (SMM) transducers ,reduced-order modelling (ROM) ,micro-electro-mechanical systems (MEMS) ,geometry/circuit/system level simulation ,finite element method (FEM) ,modal decomposition ,VHDL-AMS ,model extraction - Abstract
In this paper the creation of "virtual prototypes" of complex micro-electro-mechanical transducers is presented. Creating these behavioural models can be partially automatised using a reduced-order modelling (ROM) method. It uses modal decomposition to represent the movement of flexible structures. Shape functions model the energy conservation and full coupling between the different physical domains. Both modal shapes and shape functions for strain energy and lumped capacitances of the structure can be derived in a highly automated way from a detailed 3D finite elements (FE) model available from earlier design stages. Separating the generation of the reduced-order models (ROM) from the same FE model but for different operation directions circumvents current limitations of the used ROM method. These sub models are integrated into a full model of the transducer. VHDL-AMS is used to describe additional strong coupling effects between the different operation directions, which are not considered by the used ROM method itself. The application of this methodology on a commercially-available yaw rate sensor as an example for a complex transducer demonstrates the practical suitability of this approach.
130. Author reply to... Andrew Dickinson, Matt Gunning, Ramona Dolscheid-Pommerich, Birgit Stoffel-Wagner, Ingo Gräff, Holger Kiesewetter, Fred Zack and Andreas Büttner.
- Author
-
Franke, Axel
- Published
- 2017
- Full Text
- View/download PDF
131. [Consideration and implementation of the elements of hospital mass casualty planning in the hospitals of the TraumaNetworks DGU® : An evaluation within the framework of the development process of the guidelines for clinical disaster medicine in Germany (LeiKliKatMeD) by the EKTC, NIS, AKUT, AUC].
- Author
-
Achatz G, Bieler D, Schweigkofler U, Hoefer C, Lehmann W, and Franke A
- Abstract
Background: The protection and maintenance of hospital functionality and treatment capacity require preventative planning and preparation for a mass casualty incident with respect to the scenarios, disasters or catastrophes to be expected. The hospital alarm and operations (KAEP) or stockpiling plan should include and organize the procedures and measures in the respective clinics and hospitals. The aim of the present study was to evaluate the hospitals of the Trauma Networks of the German Society for Trauma Surgery® (TNW DGU®) with respect to the established organizational structures and contents of the KAEP., Material and Method: In this study 622 hospitals from the TNW DGU® were surveyed to determine current treatment capacities depending on the principles and standards of care. This was done via the DGU Academy of Trauma Surgery (AUC) and an online-based survey with voluntary participation via a web-based platform (SurveyMonkey Europe UC, Dublin, Ireland). The data presented here represent an excerpt of the overall data focused on the topic of this paper. Of the 622 certified clinics 252 (40%) took part in the survey in December 2022 and 250 data sets could be evaluated., Results: Level I, II, III trauma centers (LTZ, RTZ, ÜRTZ) took part in equal numbers. Of the participating clinics 90% have a KAEP that has been updated in the last 3 years. The manual of the Federal Office of Civil Protection and Disaster Assistance (BBK) was known in two thirds of the clinics surveyed. Only 30% of the clinics adapted their own KAEP after it was published and only 40% exercised it in the last 3 years. Elements for the care of those affected and injured (psychosocial network, end-of-life care, care of relatives) were included in 25-44% of hospitals. Regardless of the certification, it became obvious that around 80% of the hospitals rely exclusively on one alarm procedure and only 20% use a redundant system with 2 or more notification procedures. The survey showed that more than 75% of the hospitals already have the option of selective or partial alerting. Depending on the triage category, the LTZs were able to initially admit an average of 2 SK I and 4 SK II patients. These capacities were almost doubled by the RTZ and tripled by the ÜTZ., Conclusion: The DGU Trauma Networks represent an essential part for the care in disaster and major disaster situations. The KAEP has been implemented in the majority of hospitals. Updating the KAEPs to current content, practicing and digital, selective and redundant systems for alerting represent a challenge. In addition, the harmonization of terms and organizational elements but also the establishment of care for relatives and the care and psychosocial emergency treatment (PSNV) have not yet been fully implemented. Ultimately, a KAEP must be implemented to make hospitals and the healthcare system more resilient to disasters and major disasters. It is important to support the hospitals and ensure that costs for exercises and training course formats are covered., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
132. [Care for Seriously Injured People in Military Conflicts].
- Author
-
Franke A, Sahm J, Bieler D, and Achatz G
- Subjects
- Humans, Germany, Ukraine, Military Personnel, Afghan Campaign 2001-, Armed Conflicts, Military Medicine, War-Related Injuries therapy, Multiple Trauma therapy
- Abstract
The current war in Ukraine has drawn public attention to the treatment of war injuries. Follow-up treatment in Germany is portrayed the clover leaf of the TraumaNetzwerke DGU, is largely based on the demands of the Federal Ministries for Defence and Health and is intended to enhance resilience in war.The present article presents the special features of the care of severely injured patients during hostilities and should provide insights into the expected results of treatment and the actual procedures. We emphasise the unpredictability of the care of the severely injured during hostilities.On the basis of a search of the literature for the deployment of the German Army in Afghanistan and for the current war in Ukraine, we present the challenges and the typical patterns of injuries. We discuss the factors that can influence the procedures and the quality of the results during hostilities and how these may differ from civil polytrauma care in Germany - which is well established and standardised.Even during deployment of the Federal Army or (as planned) NATO, care of the severely injured is under standardised conditions, as based on the algorithmic ATLS care and which is concentrated on bleeding control. The corresponding equipment and personnel are well established, well prepared and well trained.However, there may be special local conditions or special deployments that make it inevitable that emergency medical care will be more delayed than in the civil system in Germany and can only take place after protracted transport. The objective is always that soldiers in combat should be able to receive medical care that is equivalent to that received by all accident victims in Germany, whatever the time and site of the accident., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
133. [Challenge of limb care after violence and war with a special focus on imaging procedures].
- Author
-
Achatz G, Franke A, Friemert B, Forstmeier V, Andres T, Wendlandt M, Grunert M, von Lübken F, and Bieler D
- Subjects
- Humans, Extremities injuries, Extremities diagnostic imaging, Military Medicine methods, Violence, War-Related Injuries therapy, Warfare, Plastic Surgery Procedures methods
- Abstract
Background: Injury patterns in the area of the extremities following violence and war harbor many special features and require special attention. Destructive and complex defect injuries are often present, which necessitate elaborate and special reconstruction approaches, predominantly as part of a staged and multistaged procedure., Research Question: In this context, special attention must be paid to the diagnostic options as an essential aspect, as a clear diagnosis means that targeted treatment steps can be planned and implemented., Material and Method: The authors' experience in this field from military operations in Afghanistan, Iraq, the Republic of Mali, Kosovo and Georgia, as well as the core content of the Terror and Disaster Surgical Care (TDSC®) course on this topic, have been contextualized and incorporated. In addition, aspects of interdisciplinary cooperation with radiological and, in particular, nuclear medicine disciplines are taken into account in the daily routine., Results and Discussion: Extremity injuries in the context of violence and war are accompanied by complex bone and surrounding soft tissue defects due to the high energy impact. The principles of reconstruction familiar from everyday life can only be transferred one-to-one to a limited extent. The treatment pathways are often very long and complex and the questions of infection and tissue vitality must be answered again and again in stages. Interdisciplinary collaboration with the disciplines specialized in imaging procedures, particularly in the field of nuclear medicine, is one of the key building blocks for a successful treatment pathway., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
134. [Microbiological challenges in the treatment of war injuries].
- Author
-
Bieler D, Kollig E, Weber W, Hackenberg L, Pavlu F, Franke A, Friemert B, and Achatz G
- Subjects
- Humans, Germany, War-Related Injuries, Plastic Surgery Procedures methods, Military Medicine history, Military Medicine methods, Wound Infection microbiology, Wound Infection drug therapy, Antimicrobial Stewardship, Warfare, Anti-Bacterial Agents therapeutic use
- Abstract
The treatment of war injuries represents a continuing and recurrent challenge in modern reconstructive surgery. Previously, tumor resections and sepsis-related resections were mainly responsible for lengthy bone defects in Germany. In recent years another picture has increasingly emerged, particularly caused by the medical support of Ukraine. Aspects of military surgery are also becoming more important in civil hospitals, especially in the treatment of gunshot and explosion injuries. In Germany, war injuries are currently secondarily treated, as the distribution of patients is carried out according to the cloverleaf principle, weeks or months after the occurrence of the primary injury. In addition to complex bone and soft tissue defects of the extremities following such injuries, which often affect neural and vascular structures, reconstruction is often complicated by an increasing spectrum of multidrug-resistant pathogens. The definition of microbiological terms, such as contamination, colonization, critical colonization, local and systemic infections are important in the clinical routine in order to initiate a targeted treatment, especially in treatment with antibiotics. Wound swabs for determination of the spectrum of pathogens and the optimal testing of resistance are important for selecting the appropriate antibiotic agents. The concept of antibiotic stewardship (ABS) is established in many hospitals to improve the quality of antibiotic treatment and to minimize the formation of resistance. The selection of the method of reconstruction depends on the condition of the patient, the overall clinical constellation and the function to be expected after completion of treatment. The treatment of injuries due to violence and terrorism necessitates clear concepts and an interdisciplinary approach, especially with respect to microbiological challenges and increasing resistance situations., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
135. [Initial in-hospital treatment of patients with penetrating trauma due to violence and war].
- Author
-
Achatz G, Franke A, Friemert B, Hoth P, Hube P, and Bieler D
- Subjects
- Humans, Germany, Hospitalization, Military Medicine methods, Violence psychology, War-Related Injuries therapy, Warfare, Wounds, Penetrating therapy, Wounds, Penetrating surgery
- Abstract
Background: Current political and social developments have brought the topics of violence, in this context attributable to terrorism and sabotage, and since February 2022 awareness of war in particular has again greatly increased. This article aims to present the contextualized dealing with penetrating injuries in terms of initial in-hospital treatment., Objective: The question remains to be answered as to what extent penetrating injuries require special attention and to what extent the treatment priorities, options and strategies as well as surgical treatment require adaptation of the usual approach in routine clinical practice in Germany., Material and Method: The experience of the authors in this field from military operations in Afghanistan, Iraq, the Republic of Mali, Kosovo and Georgia as well as the core content of the Terror and Disaster Surgical Care (TDSC®) course on this topic, have been contextualized and incorporated. In addition, aspects of a comprehensive systematic literature review and current data from a national evaluation on the topic of preparing hospitals in Germany for such scenarios are taken into account., Results and Discussion: The clinical systems need to be well-prepared for such casualties, especially if they require treatment in large numbers. This is precisely so because the majority of patients are in a relevantly threatening situation (usually in the sense of a hemorrhage), treatment must be very urgently provided and in such scenarios a lack of resources must always be overcome, at least temporarily, especially for example for blood transfusions., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
136. [National challenges for trauma surgery in Germany due to violence and war].
- Author
-
Franke A, Bieler D, Lehmann W, Pohlemann T, Friemert B, and Achatz G
- Subjects
- Germany, Humans, Traumatology, Terrorism, War-Related Injuries surgery, Ukraine, Acute Care Surgery, Violence psychology
- Abstract
Due to the war in Ukraine and the treatment of patients with war wounds in the hospitals of the TraumaNetworks of the German Society for Trauma Surgery (TraumaNetzwerke DGU®), injuries from life-threatening mission situations (LebEL), terrorism, violence and war have become a matter of daily professional life. Furthermore, the societal and global feeling of security has fundamentally changed. The much-cited term "turning point in history", the reorientation of the Armed Forces and the investigation of the resilience of the healthcare system with respect to the "fitness for war", approximate to the description of the current challenges for trauma surgery (UCH) in Germany. Based on the developments following the terrorist attacks in Paris in 2015 and in Brussels in 2016, a clarification is given as to which adaptations have already been successful and how quickly an improvement could successfully be achieved. In this context, the concept of tactical care and the course on Terror and Disaster Surgical Care (TDSC), for example, have been game changing. The main challenge currently lies in overcoming the structural alterations in the German healthcare system and professionally in the treatment of war wounded personnel from Ukraine. The knowledge gained from these two national tasks must be analyzed for the future development and adaptation of established treatment structures, e.g., of the TraumaNetzwerke DGU®, under the requirements of the increased resilience against war, terrorism and violence. The aim is to name that which has already been achieved with respect to the national challenges for UCH and at the same time to outline or discuss further necessities for improvements and elimination of possible gaps in capabilities., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
137. New Recommendations for the Care of Severely Injured Patients: Revision of the S3 Guideline on Treatment of Polytrauma/Severe Injuries.
- Author
-
Benning D, Hackenberg L, Pavlu F, Weber W, Franke A, Kollig E, and Bieler D
- Abstract
Die 3. Überarbeitung der S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung wurde unter der Federführung der Deutschen Gesellschaft für Unfallchirurgie (DGU) von insgesamt 26 Fachgesellschaften und Organisationen durchgeführt und stellt eine umfassende Aktualisierung der Handlungsempfehlungen zur Schwerverletzten-Versorgung auf Basis neuer wissenschaftlicher Erkenntnisse und Studien dar. Die Leitlinie enthält 332 Kernempfehlungen unterschiedlicher Empfehlungsgrade und dazugehörige Erläuterungen, die Expertenwissen und über 2400 zitierte Literaturstellen berücksichtigen und somit das höchste Niveau (S3) einer Leitlinie erfüllen. Die Änderungen, insbesondere zur Schockraumalarmierung, sind für den Rettungsdienst von besonderer Bedeutung. Zwei neue Kapitel mit Empfehlungen für die Blutstillung und Schmerzbehandlung in der prähospitalen Versorgung wurden hinzugefügt, insgesamt bleibt die Leitlinie ein wichtiger Standard für Entscheidungsfindungen bei Diagnostik und Therapie von Schwerverletzten., Competing Interests: DB ist Leitlinienkoordinator der aktuellen Aktualisierung der S3-Leitlinie Polytrauma. Alle anderen Autoren geben keinen Interessenkonflikt an., (Thieme. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
138. [Treatment of the wounded from the war in Ukraine in the trauma networks of the DGU-Requirement, reality and motivation over the course of 18 months…].
- Author
-
Franke A, Bieler D, Dühr S, Friemert B, Lehmann W, and Matthes G
- Subjects
- Humans, Ukraine, Hospitals, Surveys and Questionnaires, Motivation, Trauma Centers
- Abstract
Background: The war in Ukraine and the medical treatment of the wounded in hospitals in Germany has now represented a challenge for more than 15 months. The majority of trauma patients were distributed via the general holding center (GMLZ) at the Federal Office of Civil Protection and Disaster Assistance (BBK) by the cloverleaf concept and the trauma networks. Initially, numerous offers of assistance were promoted with great solidarity. For documentation of the current motivation situation and also for identification of the potential for improvement, a 2-stage survey of senior physicians in the organized and certified hospitals in the trauma networks was carried out., Material and Methods: An online survey of senior physicians of the trauma network hospitals was carried out with a semistructured written questionnaire in December 2022 and a follow-up survey during the Trauma Network Meeting (TNT) Congress in September 2023 in Frankfurt., Results: Of the questionnaires 113 could be evaluated in December 2022 and 70 completed questionnaires in September 2023. The answers came from national trauma centers (ÜTZ), regional trauma centers (RTZ) and local trauma centers (LTZ) each with approximately one third. On average 2.7 patients were treated in all participating hospitals up to December and up to September no more than 5 in more than half of the hospitals overall. The main challenges for all participants at both points in time were the long hospital stay, the demanding pathogen status and sometimes unclarified or not completely covered reimbursement of costs. Nevertheless, more than 80% of the specialist departments received backing from their hospital sponsors as well as their personnel for the continuing treatment of the wounded from Ukraine., Conclusion: The medical and professional challenges in the treatment of the wounded from Ukraine are, as expected, characterized by the demanding injury patterns of the musculoskeletal system and the colonization with multidrug-resistant pathogens. This results in a long course of treatment, where the remuneration does not always cover the costs. Despite these challenges the solidarity in the hospitals of the trauma networks is unbroken. Simultaneously, there are numerous possibilities for improvement in order to enhance the prerequisites for future comparable humanitarian assistance jointly with politics., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
139. [Inpatient surgical treatment in mass casualty situations and disasters-Current treatment capacities depending on alarm status of the hospital and treatment concept].
- Author
-
Franke A, Lehmann W, and Wurmb T
- Subjects
- Humans, Inpatients, Triage methods, Hospitals, Disaster Planning methods, Mass Casualty Incidents
- Abstract
Background: The functionality and treatment capacity of hospitals are decisive components to safeguard the in-hospital treatment of patients in crises and catastrophes. This is shown by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic and the war in Ukraine. The aim of this study is the elicitation of treatment capacities of hospitals in the trauma network of the German Society for Trauma Surgery (DGU) assuming a damage situation with a multitude of trauma patients needing treatment., Material and Method: The 622 hospitals in the trauma network were surveyed to elicit the current treatment capacities depending on the principles and standards of treatment. For this purpose, a questionnaire for voluntary participation in the survey was placed online via the Academy of Trauma Surgery (AUC) of the DGU and an electronic platform (SurveyMonkey). The data presented in this article represent an extract of the total data focussed on the issues involved in the study., Results: A total of 252 of the 622 hospitals certified in December 2022 (40%) participated in the survey and 250 datasets could be utilized. Local, regional and supraregional trauma centers were equally represented. Using a tactical abbreviated surgical control (TASC) focussed on survival, the treatment capacities in the individual triage categories could be increased with respect to the scenarios in question. It was also clear that the availability of teams skilled in the surgical treatment of body cavity injuries still represents a challenge., Conclusion: The results of the survey demonstrate the extent to which treatment capacities for the care of injured and wounded patients are currently available in the hospitals of the DGU trauma network and to what extent they can be increased. In this way, due the dynamics a mass casualty incident can initially lead locally and temporarily to a decompensated crisis management. The aim of all efforts and preparations must therefore be to durably strengthen hospitals so that this can be avoided as reliably as possible and to include these considerations in the hospital structural reform., (© 2023. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
140. [Inpatient surgical treatment in mass casualty situations and disasters-Principles, targets, concepts, preparation].
- Author
-
Franke A, Lehmann W, and Wurmb T
- Subjects
- Humans, Inpatients, Delivery of Health Care, Germany, SARS-CoV-2, Disaster Planning, Mass Casualty Incidents
- Abstract
Background: The war in Ukraine and the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic have moved the resilience of the healthcare system in Germany into the focus of a broad discussion. The preparation for such a damage situation is characterized by the relationship between the available treatment capacity and needs which go far beyond the norm. The aim of a resilient healthcare system must be to adequately react to such exceptional situations. Particularly in acute disaster and mass casualty situations, medical standards and an individualized surgical treatment must be maintained for as long as possible., Material, Method and Objective: The aim of this article is to elucidate the current terminology on medical treatment of patients in disasters from a surgical perspective, to further develop available concepts and possible concepts of crisis management based on three schematically presented scenarios. Furthermore, the general reaction possibilities for mobilization of treatment capacities are described., Results: In order to uniformly collate the quality of medical treatment in a damage situation, it is meaningful to include the stages of individualized treatment, compensated crisis care and decompensated crisis care. Within the framework of a mass casualty situation or a disaster, traumatological and surgical patients are predominant and the aim must be to maintain or restore the stage of a compensated crisis management. Depending on the extent of the damage situation, this can only be realized in a timely manner independent of state boundaries and by a superordinate central management structure. For a comprehensive provision of surgical treatment capacities, the depiction of a continuous overview of the situation with current resources and structural data of the hospitals in the affected region is necessary., Conclusion: The aim of all efforts and preparations must therefore be to durably strengthen hospitals and to train and develop this with respect to coping with a damage situation in disaster medicine. In this respect it is important to establish a consensus on terminology, the type of treatment and the tactical strategic principles of surgical treatment to cope with a disaster or damage situation., (© 2023. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
141. [Care of the severely injured in mass casualty incidents : What is the difference compared to emergency room management?]
- Author
-
Franke A, Bieler D, Achatz G, Suda AJ, Hoth P, Paffrath T, and Friemert B
- Subjects
- Humans, Emergency Service, Hospital, Hospitals, Workforce, Mass Casualty Incidents, Disaster Planning methods
- Abstract
The management of a severely injured patient according to the standards and principles of individualized trauma care is a well-established procedure in many hospitals. The process is structured and standardized by the content of several course formats. In contrast, a mass casualty incident (MCI, MANV) is a rare and exceptional situation. In this case the treatment priorities and approaches are changed. The main aim in this situation is to ensure the best possible chance of survival for every casualty by organizational measures to mobilize rooms, personnel and material and to temporarily abandon the standards of individualized trauma care. To be prepared for a MCl situation it is necessary to know the realistic scenarios, to update the hospital emergency plan and to adapt all treatment procedures to the transient lack of resources. This article gives an overview of this process and summarizes the current clinical concepts to cope with a MCl situation and the current principles for the care of the severely injured involving many casualties., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
142. Education and training as a key enabler of successful patient care in mass-casualty terrorist incidents.
- Author
-
Hoth P, Roth J, Bieler D, Friemert B, Franke A, Paffrath T, Blätzinger M, and Achatz G
- Subjects
- Humans, Prospective Studies, Retrospective Studies, Patient Care, Mass Casualty Incidents, Terrorism, Disaster Planning
- Abstract
Background and Purpose: The increase in terrorist attacks with sometimes devastating numbers of victims has become a reality in Europe and has led to a fundamental change in thinking and a reorientation in many fields including health policy. The purpose of this original work was to improve the preparedness of hospitals and to provide recommendations for training., Material and Methods: We conducted a retrospective literature search based on the Global Terrorism Database (GTD) for the period 2000 to 2017. Using defined search strategies, we were able to identify 203 articles. We grouped relevant findings into main categories with 47 statements and recommendations on education and training. In addition, we included data from a prospective questionnaire-based survey on this topic that we conducted at the 3rd Emergency Conference of the German Trauma Society (DGU) in 2019., Results: Our systematic review identified recurrent statements and recommendations. A key recommendation was that regular training should take place on scenarios that should be as realistic as possible and should include all hospital staff. Military expertise and competence in the management of gunshot and blast injuries should be integrated. In addition, medical leaders from German hospitals considered current surgical education and training to be insufficient for preparing junior surgeons to manage patients who have sustained severe injuries by terrorist events., Conclusion: A number of recommendations and lessons learned on education and training were repeatedly identified. They should be included in hospital preparations for mass-casualty terrorist incidents. There appear to be deficits in current surgical training which may be offset by establishing courses and exercises., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
143. Evaluation of the decision-making process within the table-top exercise of the Terror and Disaster Surgical Care (TDSC ® ) course.
- Author
-
Achatz G, Reckziegel A, Friemert B, Blätzinger M, Hinz-Bauer S, Franke A, Bieler D, Paffrath T, and Hoth P
- Subjects
- Humans, Prospective Studies, Triage, Disasters, Disaster Planning, Wounds, Gunshot surgery
- Abstract
Purpose: The threat of terror is omnipresent in Europe and the number of attacks worldwide is increasing. The target of attacks in Europe is usually the civilian population. Incalculable dangerous situations at the scene of the event and severe injury patterns such as complex gunshot and explosion injuries with a high number of highly life-threatening people present rescue forces, emergency physicians and subsequently hospitals with medical, organizational as well as tactical and strategic challenges. The Terror and Disaster Surgical Care (TDSC
® ) course trains clinical decision-makers to meet these challenges of a TerrorMASCAL in the first 24-48 h., Methods: A table-top exercise was developed for the TDSC® course as a decision training tool, which was prospectively evaluated in six courses. The evaluation took place in 3 courses of the version 1.0, in 3 courses in the further developed version 2.0 to different target values like, e.g., the accuracy of the in-hospital triage. Furthermore, 16 TDSC® course instructors were evaluated., Results: For the evaluation, n = 360 patient charts for version 1.0 and n = 369 for version 2.0 could be evaluated. Overall, the table-top exercise was found to be suitable for training of internal clinical decision makers. Version 2.0 was also able to depict the action and decision-making paths in a stable and valid manner compared to the previous version 1.0. The evaluation of the instructors also confirmed the further value and improvement of version 2.0., Conclusion: With this prospective study, the table-top exercise of the TDSC® course was tested for decision stability and consistency of the participants' decision paths. This could be proven for the selected target variables, it further showed an improvement of the training situation. A further development of the table-top exercise, in particular also using digital modules, will allow a further optimization. http://www.bundeswehrkrankenhaus-ulm.de., (© 2023. The Author(s).)- Published
- 2023
- Full Text
- View/download PDF
144. International efforts for improved terror preparedness: a necessity and an obligation.
- Author
-
Achatz G, Bieler D, Franke A, and Friemert B
- Subjects
- Humans, Hospitalization, Terrorism
- Published
- 2023
- Full Text
- View/download PDF
145. Effect of surgical stabilization of rib fractures in polytrauma: an analysis of the TraumaRegister DGU ® .
- Author
-
Becker L, Schulz-Drost S, Spering C, Franke A, Dudda M, Lefering R, Matthes G, and Bieler D
- Subjects
- Critical Care, Humans, Intensive Care Units, Length of Stay, Retrospective Studies, Multiple Trauma complications, Multiple Trauma surgery, Rib Fractures complications
- Abstract
Purpose: In severely injured patients with multiple rib fractures the beneficial effect of surgical stabilization is still unknown. The existing literature shows divergent results and especially the indication and the right timing of an operation are subject of a broad discussion. The aim of this study was to determine the influence of a surgical stabilization of rib fractures (SSRF) on the outcome in a multi-center database with special regard to the duration of ventilation, intensive care and overall hospital stay., Methods: Data from the TraumaRegister DGU
® collected between 2008 and 2017 were used to evaluate patients over 16 years with severe rib fractures (AIS ≥ 3). In addition to the basic comparison a matched pair analysis of 395 pairs was carried out in order to find differences and to increase comparability., Results: In total 483 patients received an operative treatment and 29,447 were treated conservatively. SSRF was associated with a significantly lower mortality rate (7.6% vs. 3.3%, p = 0.008) but a longer ventilation time and longer stay as well as in the intensive care unit (ICU) as the overall hospital stay. Both matched pair groups showed a good or very good neurological outcome according to the Glasgow Outcome Scale (GOS) in 4 of 5 cases. Contrary to the existing recommendations most of the patients were not operated within 48 h., Conclusions: In our data set, obviously most of the patients were not treated according to the recent literature and showed a delay in the time for operative care of well over 48 h. This may lead to an increased rate of complications and a longer stay at the ICU and the hospital in general. Despite of these findings patients with operative treatment show a significant lower mortality rate., (© 2022. The Author(s).)- Published
- 2022
- Full Text
- View/download PDF
146. [Safety aspects, emergency preparedness and hazard prevention in hospitals concerning mass casualty incidents (MCI)/terror-related MCI : Prospects on future challenges based on survey results from the 3rd emergency conference of the DGU].
- Author
-
Hoth P, Bieler D, Friemert B, Franke A, Blätzinger M, and Achatz G
- Subjects
- Emergency Service, Hospital, Hospitals, Humans, Civil Defense, Disaster Planning methods, Mass Casualty Incidents prevention & control
- Abstract
Background: Worldwide terrorist activities since "9/11" and subsequently also in the European region have led to a rethinking in the context of the evaluation of critical infrastructure in Germany, also with respect to security at and in hospitals., Objective: This publication deals with the evaluation of existing concepts on topics such as "alerting", "security", "communication" and "preparation" in the aforementioned context., Material and Methods: Based on a literature review as well as a survey among participants of the 3rd emergency conference of the DGU (German Society for Trauma Surgery), this topic and the currently existing situation are further analyzed and presented., Results: The data obtained illustrate that while the majority of hospitals have a hospital alert and response planning, the frequency of updates and intrahospital communication to increase awareness show significant variation. Furthermore, the results illustrate a heterogeneity of the existing intrahospital alerting concepts as well as a lack of security concepts and cooperation with security and guard services. Furthermore, it is evident that the topic of a possible CBRN (chemical, biological, radiological, nuclear) threat is not yet adequately perceived or implemented in the risk analysis., Discussion: The latent threat of terrorist activities appears to have led German hospitals to address the issue of hospital alarm and response planning in their assessment as critical infrastructure and to have implemented this for the most part; however, the subordinated areas and the consequences that can be derived from alarm planning do not yet show the necessary stringency to ultimately ensure adequate responses in these special scenarios with respect to security in and at German hospitals., (© 2021. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
147. Evaluation of a standardized instrument for post hoc analysis of trauma-team-activation-criteria in 75,613 injured patients an analysis of the TraumaRegister DGU ® .
- Author
-
Bieler D, Trentzsch H, Franke A, Baacke M, Lefering R, Paffrath T, Becker L, Düsing H, Heindl B, Jensen KO, Oezkurtul O, Schweigkofler U, Sprengel K, Wohlrath B, and Waydhas C
- Subjects
- Germany, Humans, Injury Severity Score, Length of Stay, Registries, Accidents, Triage
- Abstract
Introduction: To improve the quality of criteria for trauma-team-activation it is necessary to identify patients who benefited from the treatment by a trauma team. Therefore, we evaluated a post hoc criteria catalogue for trauma-team-activation which was developed in a consensus process by an expert group and published recently. The objective was to examine whether the catalogue can identify patients that died after admission to the hospital and therefore can benefit from a specialized trauma team mostly., Materials and Methods: The catalogue was applied to the data of 75,613 patients from the TraumaRegister DGU
® between the 01/2007 and 12/2016 with a maximum abbreviated injury score (AIS) severity ≥ 2. The endpoint was hospital mortality, which was defined as death before discharge from acute care., Results: The TraumaRegister DGU® dataset contains 18 of the 20 proposed criteria within the catalogue which identified 99.6% of the patients who were admitted to the trauma room following an accident and who died during their hospital stay. Moreover, our analysis showed that at least one criterion was fulfilled in 59,785 cases (79.1%). The average ISS in this group was 21.2 points (SD 9.9). None of the examined criteria applied to 15,828 cases (average ISS 8.6; SD 5). The number of consensus-based criteria correlated with the severity of injury and mortality. Of all deceased patients (8,451), only 31 (0.37%) could not be identified on the basis of the 18 examined criteria. Where only one criterion was fulfilled, mortality was 1.7%; with 2 or more criteria, mortality was at least 4.6%., Discussion: The consensus-based criteria identified nearly all patients who died as a result of their injuries. If only one criterion was fulfilled, mortality was relatively low. However, it increased to almost 5% if two criteria were fulfilled. Further studies are necessary to analyse and examine the relative weighting of the various criteria. Our instrument is capable to identify severely injured patients with increased in-hospital mortality and injury severity. However, a minimum of two criteria needs to be fulfilled. Based on these findings, we conclude that the criteria list is useful for post hoc analysis of the quality of field triage in patients with severe injury., (© 2021. The Author(s).)- Published
- 2022
- Full Text
- View/download PDF
148. Emergency response to terrorist attacks: results of the federal-conducted evaluation process in Germany.
- Author
-
Wurmb T, Franke A, Schorscher N, Kowalzik B, Helm M, Bohnen R, Helmerichs J, Grueneisen U, Cwojdzinski D, Jung G, Lücking G, and Weber M
- Subjects
- Germany, Humans, Quality Improvement, Disaster Planning, Emergency Medical Services organization & administration, Mass Casualty Incidents, Rescue Work organization & administration, Terrorism
- Abstract
Purpose: Rescue missions during terrorist attacks are extremely challenging for all rescue forces (police as well as non-police forces) involved. To improve the quality and safety of the rescue missions during an active killing event, it is obligatory to adapt common rescue mission goals and strategies., Methods: After the recent attacks in Europe, the Federal Office of Civil Protection and Disaster Assistance started an evaluation process on behalf of the Federal Ministry of the Interior and the Federal Ministry of Health. This was done to identify weaknesses, lessons learned and to formulate new adapted guidelines., Results: The presented bullet point recommendations summarise the basic and most important results of the ongoing evaluation process for the Federal Republic of Germany. The safety of all the rescue forces and survival of the greatest possible number of casualties are the priority goals. Furthermore, the preservation and re-establishment of the socio-political integrity are the overarching goals of the management of active killing events. Strategic incident priorities are to stop the killing and to save as much lives as possible. The early identification and prioritised transportation of casualties with life-threatening non-controllable bleeding are major tasks and the shortest possible on-scene time is an important requirement with respect to safety issues., Conclusion: With respect to hazard prevention tactics within Germany, we attributed the highest priority impact to the bullet points. The focus of the process has now shifted to intense work about possible solutions for the identified deficits and implementation strategies of such solutions during mass killing incidents.
- Published
- 2020
- Full Text
- View/download PDF
149. Terrorist attacks: common injuries and initial surgical management.
- Author
-
Bieler D, Franke A, Kollig E, Güsgen C, Mauser M, Friemert B, and Achatz G
- Subjects
- Humans, Triage, Blast Injuries surgery, Emergency Service, Hospital organization & administration, Mass Casualty Incidents, Terrorism, Wounds, Gunshot surgery
- Abstract
Terrorism-related incidents and shootings that involve the use of war weapons and explosives are associated with gunshot and blast injuries. Despite the perceived threat of terrorism, these incidents and injuries are rare in Germany. For this reason, healthcare providers are unlikely to have a full understanding of the special aspects of managing these types of injuries. Until a clear and complete picture of the situation is available after a terrorist or shooter incident, tactical and strategic approaches to the clinical management of the injured must be tailored to circumstances that have the potential to overwhelm resources temporarily. Hospitals providing initial care must be aware that the first patients who are taken to medical facilities will present with uncontrollable bleeding from injuries to the trunk and body cavities. To improve the outcome of these patients in extremis, the aim of the index surgery is to stop the bleeding and control the contamination. Unlike damage control surgery, which is tailored to the patient's condition, tactical abbreviated surgical care (TASC) is first and foremost adapted to the overall situation. Once the patients are stabilised and all information on the situation is available, the surgical management and reconstruction of gunshot and blast injuries can follow the principles of damage control (DC) and definitive early total care (ETC). The purpose of this article is to provide an overview of the pathophysiology of gunshot and blast injuries, wound ballistics, and the approach and procedures of successful surgical management.
- Published
- 2020
- Full Text
- View/download PDF
150. Why do some trauma patients die while others survive? A matched-pair analysis based on data from Trauma Register DGU®.
- Author
-
Bieler D, Paffrath T, Schmidt A, Völlmecke M, Lefering R, Kulla M, Kollig E, and Franke A
- Subjects
- Accidents classification, Adult, Age Factors, Blood Transfusion, Emergency Medical Services, Female, Fluid Therapy, Germany epidemiology, Hemoglobins, Humans, International Normalized Ratio, Intubation statistics & numerical data, Male, Multiple Organ Failure, Sex Factors, Survival Rate, Trauma Severity Indices, Data Analysis, Matched-Pair Analysis, Registries, Wounds and Injuries mortality
- Abstract
Purpose: The mortality rate for severely injured patients with the injury severity score (ISS) ≥16 has decreased in Germany. There is robust evidence that mortality is influenced not only by the acute trauma itself but also by physical health, age and sex. The aim of this study was to identify other possible influences on the mortality of severely injured patients., Methods: In a matched-pair analysis of data from Trauma Register DGU®, non-surviving patients from Germany between 2009 and 2014 with an ISS≥16 were compared with surviving matching partners. Matching was performed on the basis of age, sex, physical health, injury pattern, trauma mechanism, conscious state at the scene of the accident based on the Glasgow coma scale, and the presence of shock on arrival at the emergency room., Results: We matched two homogeneous groups, each of which consisted of 657 patients (535 male, average age 37 years). There was no significant difference in the vital parameters at the scene of the accident, the length of the pre-hospital phase, the type of transport (ground or air), pre-hospital fluid management and amounts, ISS, initial care level, the length of the emergency room stay, the care received at night or from on-call personnel during the weekend, the use of abdominal sonographic imaging, the type of X-ray imaging used, and the percentage of patients who developed sepsis. We found a significant difference in the new injury severity score, the frequency of multi-organ failure, hemoglobine at admission, base excess and international normalized ratio in the emergency room, the type of accident (fall or road traffic accident), the pre-hospital intubation rate, reanimation, in-hospital fluid management, the frequency of transfusion, tomography (whole-body computed tomography), and the necessity of emergency intervention., Conclusion: Previously postulated factors such as the level of care and the length of the emergency room stay did not appear to have a significant influence in this study. Further studies should be conducted to analyse the identified factors with a view to optimising the treatment of severely injured patients. Our study shows that there are significant factors that can predict or influence the mortality of severely injured patients., (Copyright © 2020 Chinese Medical Association. Production and hosting by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.