126,048 results on '"Français A"'
Search Results
102. Design and characterization of a broadband PCB-based coaxial sensor for permittivity screening in skin cancer detection applications
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Fritiss, Mohamed Zied, primary, Poulichet, Patrick, additional, Takhedmit, Hakim, additional, Lanquetin, Laurent, additional, Protat, Stephane, additional, Vallade, Patrice, additional, Richalot, Elodie, additional, and Français, Olivier, additional
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- 2023
- Full Text
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103. Design and characterisation of a broadband PCB coaxial sensor for non-invasive skin cancer analysis
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Fritiss, Mohamed Zied, primary, Poulichet, Patrick, additional, Takhedmit, Hakim, additional, Lanquetin, Laurent, additional, Protat, Stephane, additional, Vallade, Patrice, additional, Richalot, Elodie, additional, and Français, Olivier, additional
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- 2023
- Full Text
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104. Electrorotation as a Versatile Tool to Estimate Dielectric Properties of Multi-scale Biological Samples: from Single Cell to Spheroid Analysis
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Trainito, C. I., Bayart, E., Bisceglia, E., Subra, F., Français, O., Le Pioufle, B., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor
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- 2016
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105. A Microfluidic Device for the Real-Time Characterization of Lipid Producing Algae Cell Population Submitted to a Pulsed Electric Field
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Bodénès, P., Lopes, F., Pareau, D., Français, O., Le Pioufle, B., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor
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- 2016
- Full Text
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106. Randomized Open-label Trial to Compare Efficacy and Tolerance of Corticosteroids and IVIg (PRNC)
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Laboratoire français de Fractionnement et de Biotechnologies
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- 2014
107. Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study
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van den Bent, Martin J, Baumert, Brigitta, Erridge, Sara C, Vogelbaum, Michael A, Nowak, Anna K, Sanson, Marc, Brandes, Alba Ariela, Clement, Paul M, Baurain, Jean Francais, Mason, Warren P, Wheeler, Helen, Chinot, Olivier L, Gill, Sanjeev, Griffin, Matthew, Brachman, David G, Taal, Walter, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H, Weber, Damien C, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Pascoe, Sarah, Herrlinger, Ulrich, Hau, Peter, Dhermain, Frederic, van Heuvel, Irene, Stupp, Roger, Aldape, Ken, Jenkins, Robert B, Dubbink, Hendrikus Jan, Dinjens, Winand N M, Wesseling, Pieter, Nuyens, Sarah, Golfinopoulos, Vassilis, Gorlia, Thierry, Wick, Wolfgang, and Kros, Johan M
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- 2017
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108. Compte rendu du séminaire de travail du Collège français d’échographie fœtal (CFEF) sur les référentiels et standards de biométrie fœtale. Juin 2017
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Collège français d’échographie fœtale (CFEF)
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- 2017
- Full Text
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109. Characterization of red blood cell microcirculatory parameters using a bioimpedance microfluidic device
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Xu, Tieying, Lizarralde-Iragorri, Maria A., Roman, Jean, Ghasemi, Rasta, Lefèvre, Jean-Pierre, Martincic, Emile, Brousse, Valentine, Français, Olivier, El Nemer, Wassim, and Le Pioufle, Bruno
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- 2020
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110. Impact of pulsed electric fields and mechanical compressions on the permeability and structure of Chlamydomonas reinhardtii cells
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Bensalem, Sakina, Pareau, Dominique, Cinquin, Bertrand, Français, Olivier, Le Pioufle, Bruno, and Lopes, Filipa
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- 2020
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111. Basics of Micro/Nano Fluidics and Biology
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Français, Olivier, primary, Madec, Morgan, additional, Dumas, Norbert, additional, Funfschilling, Denis, additional, and Uhring, Wilfried, additional
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- 2019
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112. Catalogue Officiel illustré de L’Exposition Centennale
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Français, De L’art, primary
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- 2019
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113. Orthopédie Traumatologie : Conforme à la réforme des EDN Ed. 3
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Collège Français des Chirurgiens Orthopédistes et Traumatologues, Collège Français des Chirurgiens Orthopédistes et Traumatologues, Collège Français des Chirurgiens Orthopédistes et Traumatologues, and Collège Français des Chirurgiens Orthopédistes et Traumatologues
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Proposant des ouvrages de cours de référence, la collection ECNi - LES REFERENTIELS tient compte de l’évolution des enseignements et des besoins des étudiants qui préparent les ECNi. Ses auteurs – tous professeurs universitaires - s’attachent à fournir au lecteur un outil complet de révisions, conforme au programme du concours. Dans cet ouvrage, le programme de la spécialité Orthopédie-Traumatologie est traité de façon complète, avec : Un cours de référence en accord avec les conférences de consensus ; Des tableaux, des encadrés et de l'iconographie en couleur pour y voir plus clair ; L’essentiel à retenir. Cet ouvrage très explicatif facilite l’apprentissage des notions en privilégiant leur compréhension, afin de réussir les ECNi.
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- 2022
114. Le grand livre de ma grossesse : Édition 2023-2024 Ed. 10
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Collège National Des Gynécologues Et Obstétriciens Français (Cngof), Hédon, Bernard, Evrard, Nicolas, Collège National Des Gynécologues Et Obstétriciens Français (Cngof), Collège National Des Gynécologues Et Obstétriciens Français (Cngof), Hédon, Bernard, Evrard, Nicolas, and Collège National Des Gynécologues Et Obstétriciens Français (Cngof)
- Abstract
Véritable mine d'informations concrètes et rassurantes, ce livre est le résultat du travail d'experts du Collège national des gynécologues et obstétriciens français (CNGOF). Ils ont compilé leur savoir pour le rendre accessible à toutes et vous permettre de vivre pleinement la merveilleuse aventure de votre grossesse. Les spécialistes du domaine (gynécologues, sages-femmes, pédiatres, pédopsychiatres, acupuncteurs, homéopathes...) répondent avec bienveillance à toutes les questions que vous vous posez pour vous aider à : comprendre tous les mécanismes de votre grossesse, du désir d'enfant à la fécondation ; suivre votre grossesse, mois par mois, semaine après semaine ; décrypter ce que le médecin voit et recherche à l'échographie ; connaître les traitements possibles contre les petits maux ; préparer votre accouchement ; anticiper votre retour à la maison avec bébé ; effectuer toutes les démarches administratives... Un guide ultra complet : près de 500 pages, 140 schémas explicatifs, 45 échographies décryptées et de nombreuses vidéos gratuites pour suivre mois par mois l'évolution de votre grossesse et préparer l'arrivée de bébé.
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- 2022
115. Intégrer l’étude des représentations linguistiques aux pratiques didactiques de l’enseignement du FLE.
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Enseignement et apprentissage du français comme langue, culture et vision du monde — Recherches transversales et pluridisciplinaires (13 et 14 octobre 202: Kaohsiung, Taiwan), Tielemans, Leyla, Enseignement et apprentissage du français comme langue, culture et vision du monde — Recherches transversales et pluridisciplinaires (13 et 14 octobre 202: Kaohsiung, Taiwan), and Tielemans, Leyla
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La notion de représentation linguistique (RL) intéresse aujourd’hui toutes les disciplines « sociocompatibles », pour reprendre l’expression du professeur Laurent Gajo — et la didactique des langues ne fait pas exception. La recherche a montré depuis longtemps que les représentations entretiennent un lien complexe et ambivalent avec les processus d’apprentissage, qu’elles contribuent à fortifier ou à ralentir. Ainsi, en ce qui concerne les langues, la perception de leur utilité, facilité, esthétique ou encore du capital sympathie des locuteurs encourage ou décourage le choix de les apprendre. Une fois le choix effectué ou imposé, les RL des apprenants guideront leur apprentissage et leur utilisation de la langue en question. En fait, leurs RL seront même déterminantes pour la réussite ou pour l’échec du processus d’acquisition. Elles constituent donc un enjeu de taille en didactique des langues-cultures, dès lors que leur étude permet, d’une part, de comprendre des dynamiques à l’œuvre durant l’utilisation et l’enseignement-apprentissage des langues, et, d’autre part, de mettre en place des stratégies didactiques appropriées.Cette contribution vise à introduire les enjeux de l’étude des représentations linguistiques (RL) dans le cadre de la didactique du français langue étrangère. Nous présenterons brièvement les aspects théoriques de cette notion extrêmement riche. À l’aide d’exemples concrets, nous explorerons le potentiel de l’étude des RL, autant pour le chercheur en didactique que pour l’enseignant de FLE., info:eu-repo/semantics/nonPublished
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- 2023
116. L’intervention précoce dans la psychose :l’impact des jeunes psychiatres dans la pratique clinique
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Congrès Français de Psychiatrie (15ème: 29/11-02/12/2023: Lyon (France)), Marchini, Simone, Congrès Français de Psychiatrie (15ème: 29/11-02/12/2023: Lyon (France)), and Marchini, Simone
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2023
117. Continuité des soins à l’âge de transition (16-24 ans) :quel est le dispositif le plus approprié ?
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Congrès Français de Psychiatrie (15ème: 29/11-02/12/2023: Lyon (France)), Marchini, Simone, Purper-Ouakil, Diane, Frédéric, Haesebaert, Congrès Français de Psychiatrie (15ème: 29/11-02/12/2023: Lyon (France)), Marchini, Simone, Purper-Ouakil, Diane, and Frédéric, Haesebaert
- Abstract
info:eu-repo/semantics/nonPublished
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- 2023
118. Marine heatwaves on the rise: One of the strongest ever observed mass mortality event in temperate gorgonians
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Office français de la biodiversité (France), Agencia Estatal de Investigación (España), European Commission, Estaque, Tristan, Richaume, Justine, Bianchimani, Olivier, Schull, Quentin, Mérigot, Bastien, Bensoussan, Nathaniel, Bonhomme, Patrick, Vouriot, Pauline, Sartoretto, Stéphane, Monfort, Tiffany, Basthard-Bogain, Sòlene, Fargetton, Margaux, Gatti, Giulia, Barth, Laura, Cheminée, Adrien, Garrabou, Joaquim, Office français de la biodiversité (France), Agencia Estatal de Investigación (España), European Commission, Estaque, Tristan, Richaume, Justine, Bianchimani, Olivier, Schull, Quentin, Mérigot, Bastien, Bensoussan, Nathaniel, Bonhomme, Patrick, Vouriot, Pauline, Sartoretto, Stéphane, Monfort, Tiffany, Basthard-Bogain, Sòlene, Fargetton, Margaux, Gatti, Giulia, Barth, Laura, Cheminée, Adrien, and Garrabou, Joaquim
- Abstract
Climate change is currently impacting and threatening the entire biosphere, especially coastal marine ecosystems (Harley et al., 2006). In particular, climate change has been identified as a major driver of loss in coastal marine biodiversity and ecosystem functioning linked to the increase in the frequency and the intensity of marine heatwaves (MHWs)—anomalously prolonged periods of warm ocean temperatures or extremely warm temperature during short periods (Smith et al., 2023). The Mediterranean Sea has particularly experienced widespread mass mortality events (MMEs) driven by MHWs across the basin over the last two decades (Garrabou et al., 2022). During summer 2022, the NW Mediterranean was affected by one of the strongest MME ever recorded in the region affecting several species including gorgonians, sponges, bryozoans, bivalve molluscs, and calcareous algae. As in previous MMEs, mortality in these species resulted in the development of tissue necrosis affecting part of or the entirety of colonies (Figure 1a). In the Calanques National Park, France, two of its most emblematic species, the red gorgonian (Paramuricea clavata) and the red coral (Corallium rubrum), were dramatically affected. [...]
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- 2023
119. Continuité des soins à l’âge de transition (16-24 ans) :quel est le dispositif le plus approprié ?
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Congrès Français de Psychiatrie (15ème: 29 novembre - 1er décembre 2023: Lyon (France)), Marchini, Simone, Purper-Ouakil, Diane, Congrès Français de Psychiatrie (15ème: 29 novembre - 1er décembre 2023: Lyon (France)), Marchini, Simone, and Purper-Ouakil, Diane
- Abstract
info:eu-repo/semantics/nonPublished
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- 2023
120. L’intervention précoce dans la psychose :l’impact des jeunes psychiatres dans la pratique clinique
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Congrès Français de Psychiatrie (15ème: 29 novembre - 1er décembre 2023: Lyon (France)), Marchini, Simone, Congrès Français de Psychiatrie (15ème: 29 novembre - 1er décembre 2023: Lyon (France)), and Marchini, Simone
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info:eu-repo/semantics/nonPublished
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- 2023
121. Arctic mercury flux increased through the Last Glacial Termination with a warming climate
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A.P. Moller Foundation, University of Copenhagen, National Science Foundation (US), Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (Germany), National Institute of Polar Research (Japan), University of Bergen, Swiss National Science Foundation, Institut Polaire Français Paul Emile Victor, Institut des Géosciences de l'Environnement (France), University of Manitoba, Chinese Academy of Sciences, Beijing Normal University, European Commission, Ministry of Earth Sciences (India), Canada Research Chairs, Oeschger Centre for Climate Change Research (Switzerland), Aarhus University Research Foundation, Segato, Delia [0000-0003-3375-3319], Saiz-Lopez, A. [0000-0002-0060-1581], Mahajan, Anoop Sharad `[0000-0002-2909-5432], Wang, Feiyue [0000-0001-5297-0859], Corella, Juan Pablo [0000-0001-5127-9011], Cuevas, Carlos A. [0000-0002-9251-5460], Erhardt, Tobias [0000-0002-6683-6746], Zeppenfeld, Chantal [0000-0002-6340-5836], Kjær, Helle Astrid [0000-0002-3781-9509], Turetta, Clara [0000-0003-3130-2901], Cairns, Warren Raymond Lee [0000-0002-7128-7753], Barbante, Carlo [0000-0003-4177-2288], Spolaor, Andrea [0000-0001-8635-9193], Segato, Delia, Saiz-Lopez, A., Mahajan, Anoop Sharad, Wang, Feiyue, Corella, Juan Pablo, Cuevas, Carlos A., Erhardt, Tobias, Jensen, Camilla Marie, Zeppenfeld, Chantal, Kjær, Helle Astrid, Turetta, Clara, Cairns, Warren Raymond Lee, Barbante, Carlo, Spolaor, Andrea, A.P. Moller Foundation, University of Copenhagen, National Science Foundation (US), Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (Germany), National Institute of Polar Research (Japan), University of Bergen, Swiss National Science Foundation, Institut Polaire Français Paul Emile Victor, Institut des Géosciences de l'Environnement (France), University of Manitoba, Chinese Academy of Sciences, Beijing Normal University, European Commission, Ministry of Earth Sciences (India), Canada Research Chairs, Oeschger Centre for Climate Change Research (Switzerland), Aarhus University Research Foundation, Segato, Delia [0000-0003-3375-3319], Saiz-Lopez, A. [0000-0002-0060-1581], Mahajan, Anoop Sharad `[0000-0002-2909-5432], Wang, Feiyue [0000-0001-5297-0859], Corella, Juan Pablo [0000-0001-5127-9011], Cuevas, Carlos A. [0000-0002-9251-5460], Erhardt, Tobias [0000-0002-6683-6746], Zeppenfeld, Chantal [0000-0002-6340-5836], Kjær, Helle Astrid [0000-0002-3781-9509], Turetta, Clara [0000-0003-3130-2901], Cairns, Warren Raymond Lee [0000-0002-7128-7753], Barbante, Carlo [0000-0003-4177-2288], Spolaor, Andrea [0000-0001-8635-9193], Segato, Delia, Saiz-Lopez, A., Mahajan, Anoop Sharad, Wang, Feiyue, Corella, Juan Pablo, Cuevas, Carlos A., Erhardt, Tobias, Jensen, Camilla Marie, Zeppenfeld, Chantal, Kjær, Helle Astrid, Turetta, Clara, Cairns, Warren Raymond Lee, Barbante, Carlo, and Spolaor, Andrea
- Abstract
Mercury is a pollutant of global concern, especially in the Arctic, where high levels are found in biota despite its remote location. Mercury is transported to the Arctic via atmospheric, oceanic and riverine long-range pathways, where it accumulates in aquatic and terrestrial ecosystems. While present-day mercury deposition in the Arctic from natural and anthropogenic emissions is extensively studied, the control of past climate changes on natural mercury variability remains unknown. Here we present an Arctic mercury record covering the Last Glacial Termination to the early Holocene epoch (15.7–9.0 thousand years before 2000 ce), collected as part of the East Greenland Ice-Core Project. We find a threefold increase in mercury depositional fluxes from the Last Glacial Termination into the early Holocene, which coincided with abrupt regional climate warming. Atmospheric chemistry modelling, combined with available sea-ice proxies, indicates that oceanic mercury evaporation and atmospheric bromine drove the increase in mercury flux during this climatic transition. Our results suggest that environmental changes associated with climate warming may contribute to increasing mercury levels in Arctic ecosystems.
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- 2023
122. Demographic responses of Arctic seabirds to spring sea-ice variations
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European Commission, Institut Polaire Français, Fondation BNP Paribas, Agencia Estatal de Investigación (España), Sauser, Christophe, Angelier, Frédéric, Blévin, P., Chastel, Olivier, Gabrielsen, G.W., Jouanneau, W., Kato, Akiko, Moe, Børge, Ramírez Benítez, Francisco, Tartu, S., Descamps, Sébastien, European Commission, Institut Polaire Français, Fondation BNP Paribas, Agencia Estatal de Investigación (España), Sauser, Christophe, Angelier, Frédéric, Blévin, P., Chastel, Olivier, Gabrielsen, G.W., Jouanneau, W., Kato, Akiko, Moe, Børge, Ramírez Benítez, Francisco, Tartu, S., and Descamps, Sébastien
- Abstract
The Arctic experiences a rapid retreat of sea-ice, particularly in spring and summer, which may dramatically affect pagophilic species. In recent years, the decline of many Arctic seabird populations has raised concerns about the potential role of sea-ice habitats on their demography. Spring sea-ice drives the dynamics of phytoplankton blooms, the basis of Arctic food webs, and changes in spring sea-ice have the potential to affect the demographic parameters of seabirds through bottom-up processes. To better understand the effects of spring sea-ice on Arctic seabirds, we investigated the influence of spring sea-ice concentration on the survival and breeding success of three seabird species with contrasted foraging strategies in two Svalbard fjords in the high Arctic. We examined these relationships using long-term demographic data (2005–2021) from black-legged kittiwakes (Rissa tridactyla), Brünnich guillemots (Uria lomvia), and little auks (Alle alle). Spring sea-ice concentration was positively related to both the survival and breeding success of little auks, suggesting a higher sensitivity of this species to spring sea-ice. By contrast, the two other species were not particularly sensitive to changes in spring sea-ice, even though a potentially spurious negative effect on the breeding success of black-legged kittiwakes was observed. Overall, the study suggests that spring sea-ice may be involved in the demography of Arctic seabirds, but probably does not play a major role
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- 2023
123. A robust approach to estimate relative phytoplankton cell abundances from metagenomes
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European Commission, Fonds Français pour l'Environnement Mondial, Université Paris Sciences & Lettres, Agencia Estatal de Investigación (España), Pierella Karlusich, Juan J., Pelletier, Eric, Zinger, Lucie, Lombard, Fabien, Zingone, Adriana, Colin, Sebastien, Gasol, Josep M., Dorrell, Richard G., Henry, Nicolas, Scalco, Eleonora, Acinas, Silvia G., Wincker, Patrick, Vargas, Colomban de, Bowler, Chris, European Commission, Fonds Français pour l'Environnement Mondial, Université Paris Sciences & Lettres, Agencia Estatal de Investigación (España), Pierella Karlusich, Juan J., Pelletier, Eric, Zinger, Lucie, Lombard, Fabien, Zingone, Adriana, Colin, Sebastien, Gasol, Josep M., Dorrell, Richard G., Henry, Nicolas, Scalco, Eleonora, Acinas, Silvia G., Wincker, Patrick, Vargas, Colomban de, and Bowler, Chris
- Abstract
Phytoplankton account for >45% of global primary production, and have an enor-mous impact on aquatic food webs and on the entire Earth System. Their members are found among prokaryotes (cyanobacteria) and multiple eukaryotic lineages con-taining chloroplasts. Genetic surveys of phytoplankton communities generally consist of PCR amplification of bacterial (16S), nuclear (18S) and/or chloroplastic (16S) rRNA marker genes from DNA extracted from environmental samples. However, our appre-ciation of phytoplankton abundance or biomass is limited by PCR-amplification biases, rRNA gene copy number variations across taxa, and the fact that rRNA genes do not provide insights into metabolic traits such as photosynthesis. Here, we targeted the photosynthetic gene psbO from metagenomes to circumvent these limitations: the method is PCR-free, and the gene is universally and exclusively present in photosyn-thetic prokaryotes and eukaryotes, mainly in one copy per genome. We applied and validated this new strategy with the size-fractionated marine samples collected by Tara Oceans, and showed improved correlations with flow cytometry and microscopy than when based on rRNA genes. Furthermore, we revealed unexpected features of the ecology of these ecosystems, such as the high abundance of picocyanobacterial aggregates and symbionts in the ocean, and the decrease in relative abundance of phototrophs towards the larger size classes of marine dinoflagellates. To facilitate the incorporation of psbO in molecular- based surveys, we compiled a curated database of >18,000 unique sequences. Overall, psbO appears to be a promising new gene marker for molecular- based evaluations of entire phytoplankton communities
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- 2023
124. Hunting at the fringe of the desert: animal exploitation at Nahal Efe (northern Negev, Israel) during the Pre-Pottery Neolithic B
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Israel Science Foundation, Ministerio de Ciencia e Innovación (España), Fundación Palarq, Irene Levi Sala Care Archaeological Foundation, Agencia Estatal de Investigación (España), Centre de recherche français à Jérusalem, Generalitat de Catalunya, Ministerio de Universidades (España), European Commission, ICREA Acadèmia, Alcàntara, Roger, Sierra, Alejandro, Gourichon, Lionel, Saña, Maria, Alejandre, Judit, Teira, Luis, Vardi, Jacob, Borrell, Ferran, Israel Science Foundation, Ministerio de Ciencia e Innovación (España), Fundación Palarq, Irene Levi Sala Care Archaeological Foundation, Agencia Estatal de Investigación (España), Centre de recherche français à Jérusalem, Generalitat de Catalunya, Ministerio de Universidades (España), European Commission, ICREA Acadèmia, Alcàntara, Roger, Sierra, Alejandro, Gourichon, Lionel, Saña, Maria, Alejandre, Judit, Teira, Luis, Vardi, Jacob, and Borrell, Ferran
- Abstract
[EN] Nahal Efe is the largest and best preserved Middle PPNB site in the Negev (Israel), constituting a privileged data source for reconstructing the animal exploitation and subsistence strategies of the hunter-gatherer communities that inhabited the Negev 10,000 years ago. The preliminary results of the study of the faunal assemblage from excavation seasons 2015–2019 are presented in this paper. The zooarchaeological study indicates that during the Middle PPNB the community of hunter-gatherers at Nahal Efe exploited a wide spectrum of animal species, favoured by the great potential in terms of animal resources that the site’s surroundings offered, in a contact area between different eco-zones. Large and middle-sized ungulates, small carnivores, hares, and birds were captured, revealing the variability and adaptability of the hunting strategies of the community at Nahal Efe. Hunting, as a source of animal-based food, focused on the exploitation of ibex (C. nubiana) and gazelle (G. gazella) in similar proportions, which were most probably transported complete or almost complete to the site and intensively processed. Finally, another remarkable aspect of the faunal assemblage is the deposit of remains of at least three species of diurnal raptors inside a pit in one of the excavated residential buildings (Unit 10), evidencing the exploitation of birds of prey, most probably to acquire raw materials (e.g. feathers and talons). The presence of fox remains at the site also seems to be related to the procurement of raw materials, furs in this case, but its consumption is also suspected., [FR] Nahal Efe est le plus grand et le mieux préservé des sites du PPNB moyen du Néguev (Israël), constituant une source de données privilégiée pour reconstruire les stratégies d’exploitation animale et de subsistance des communautés de chasseurs-cueilleurs habitant le Néguev il y a 10 000 ans. Les résultats préliminaires de l’étude de l’assemblage faunique des saisons de fouilles 2015-2019 sont présentés dans cet article. L’étude zooarchéologique indique qu’au cours du PPNB moyen, la communauté de chasseurscueilleurs de Nahal Efe a exploité un large spectre d’espèces animales, favorisé par le grand potentiel en termes de ressources animales qu’offrait l’environnement du site, dans une zone de contact entre différentes écozones. Des ongulés de grande et moyenne taille, des petits carnivores, des lièvres et des oiseaux ont été capturés, révélant la variabilité et l’adaptabilité des stratégies de chasse de la communauté de Nahal Efe. La chasse, en tant que source d’aliments d’origine animale, s’est concentrée sur l’exploitation du bouquetin (C. nubiana) et de la gazelle (G. gazella) dans des proportions similaires, qui ont très probablement été transportés complets ou presque complets sur le site et transformés de manière intensive. Par ailleurs, un autre aspect remarquable de l’assemblage faunique est le dépôt de restes d’au moins trois espèces de rapaces diurnes à l’intérieur d’une fosse dans l’un des bâtiments résidentiels fouillés (unité 10), ce qui témoigne de l’exploitation des oiseaux de proie, très probablement pour acquérir des matières premières (par exemple des plumes et des serres). La présence de restes de renards sur le site semble également liée à l’acquisition de matières premières, en l’occurrence des fourrures, mais sa consommation est également suspectée.
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- 2023
125. Ocean-wide comparisons of mesopelagic planktonic community structures
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Fonds Français pour l'Environnement Mondial, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), European Commission, Centre National de la Recherche Scientifique (France), European Molecular Biology Laboratory, Ministère de la Recherche et des Technologies (France), Agencia Estatal de Investigación (España), Rigonato, Janaina, Budinich, Marko, Murillo, Alejandro A., Brandão, Manoela C., Pierella Karlusich, Juan J., Soviadan, Yawouvi Dodji, Gregory, Ann C., Endo, Hisashi, Kokoszka, Florian, Vik, Dean, Henry, Nicolas, Frémont, Paul, Labadie, Karine, Zayed, Ahmed A., Dimier, Céline, Picheral, Marc, Searson, Sarah, Poulain, Julie, Kandels‐Lewis, Stefanie, Pesant, Stéphane, Karsenti, Eric, Tara Oceans Coordinators, Acinas, Silvia G., Bork, Peer, Bowler, Chris, Vargas, Colomban de, Eveillard, Damien, Gehlen, Marion, Iudicone, Daniele, Lombard, Fabien, Ogata, Hiroyuki, Stemmann, Lars, Sullivan, Matthew B., Sunagawa, Shinichi, Wincker, Patrick, Chaffron, Samuel, Jaillon, Olivier, Fonds Français pour l'Environnement Mondial, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), European Commission, Centre National de la Recherche Scientifique (France), European Molecular Biology Laboratory, Ministère de la Recherche et des Technologies (France), Agencia Estatal de Investigación (España), Rigonato, Janaina, Budinich, Marko, Murillo, Alejandro A., Brandão, Manoela C., Pierella Karlusich, Juan J., Soviadan, Yawouvi Dodji, Gregory, Ann C., Endo, Hisashi, Kokoszka, Florian, Vik, Dean, Henry, Nicolas, Frémont, Paul, Labadie, Karine, Zayed, Ahmed A., Dimier, Céline, Picheral, Marc, Searson, Sarah, Poulain, Julie, Kandels‐Lewis, Stefanie, Pesant, Stéphane, Karsenti, Eric, Tara Oceans Coordinators, Acinas, Silvia G., Bork, Peer, Bowler, Chris, Vargas, Colomban de, Eveillard, Damien, Gehlen, Marion, Iudicone, Daniele, Lombard, Fabien, Ogata, Hiroyuki, Stemmann, Lars, Sullivan, Matthew B., Sunagawa, Shinichi, Wincker, Patrick, Chaffron, Samuel, and Jaillon, Olivier
- Abstract
For decades, marine plankton have been investigated for their capacity to modulate biogeochemical cycles and provide fishery resources. Between the sunlit (epipelagic) layer and the deep dark waters, lies a vast and heterogeneous part of the ocean: the mesopelagic zone. How plankton composition is shaped by environment has been well-explored in the epipelagic but much less in the mesopelagic ocean. Here, we conducted comparative analyses of trans-kingdom community assemblages thriving in the mesopelagic oxygen minimum zone (OMZ), mesopelagic oxic, and their epipelagic counterparts. We identified nine distinct types of intermediate water masses that correlate with variation in mesopelagic community composition. Furthermore, oxygen, NO3− and particle flux together appeared as the main drivers governing these communities. Novel taxonomic signatures emerged from OMZ while a global co-occurrence network analysis showed that about 70% of the abundance of mesopelagic plankton groups is organized into three community modules. One module gathers prokaryotes, pico-eukaryotes and Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from oxic regions, and the two other modules are enriched in OMZ prokaryotes and OMZ pico-eukaryotes, respectively. We hypothesize that OMZ conditions led to a diversification of ecological niches, and thus communities, due to selective pressure from limited resources. Our study further clarifies the interplay between environmental factors in the mesopelagic oxic and OMZ, and the compositional features of communities
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- 2023
126. Distribution patterns of marine megafauna density in the Mediterranean Sea assessed through the ACCOBAMS Survey Initiative (ASI)
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Fondation Prince Albert II de Monaco, Ministerio de Agricultura, Alimentación y Medio Ambiente (España), Office français de la biodiversité (France), Ministero dell'Ambiente e della Tutela del Territorio e del Mare, Principality of Monaco, Cañadas, Ana, Pierantonio, Nino, Araújo, Hélder, David, Léa, Di Meglio, Nathalie, Dorémus, Ghislain, Gonzalvo, Joan, Holcer, Draško, Laran, Sophie, Lauriano, Giancarlo, Perri, Morgane, Ridoux, Vincent, Vázquez-Bonales, José Antonio, Panigada, Simone, Fondation Prince Albert II de Monaco, Ministerio de Agricultura, Alimentación y Medio Ambiente (España), Office français de la biodiversité (France), Ministero dell'Ambiente e della Tutela del Territorio e del Mare, Principality of Monaco, Cañadas, Ana, Pierantonio, Nino, Araújo, Hélder, David, Léa, Di Meglio, Nathalie, Dorémus, Ghislain, Gonzalvo, Joan, Holcer, Draško, Laran, Sophie, Lauriano, Giancarlo, Perri, Morgane, Ridoux, Vincent, Vázquez-Bonales, José Antonio, and Panigada, Simone
- Abstract
The ACCOBAMS Survey Initiative (ASI) is the first synoptic large-scale survey of the entire ACCOBAMS Area and as such it plays a key role in filling the current gaps in our biological and ecological knowledge of large vertebrate species occurring in the region. Data gathered during the ASI were analyzed in a distance sampling surface-modelling framework to assess the summer distribution, densities and patterns, as well as to investigate the correlates of these parameters, for large vertebrate species and taxa in the Mediterranean Basin. Static and dynamic explanatory variables, including water depth (m), distance to depth contours (km), distance to canyons and seabed slope (km), sea surface temperature (°C), mixed layer depth (m) and levels of chlorophyll-a (mg/l), were considered to predict density and compute its variance spatially at a resolution of 10x10 km. A strong longitudinal gradient from low densities in the east to high densities in the west is shared by most taxa. In addition, several taxa also showed a less marked latitudinal gradient varying in direction according to species, and finally, a few of them exhibited patchy distributions.
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- 2023
127. Investigating the Role of Shrub Height and Topography in Snow Accumulation on Low-Arctic Tundra using UAV-Borne Lidar
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Natural Sciences and Engineering Research Council of Canada, Fondation BNP Paribas, Institut Polaire Français Paul Emile Victor, Lamare, Maxim, Domine, Florent, Revuelto, Jesús, Pelletier, Maude, Arnaud, Laurent, Picard, Ghislain, Natural Sciences and Engineering Research Council of Canada, Fondation BNP Paribas, Institut Polaire Français Paul Emile Victor, Lamare, Maxim, Domine, Florent, Revuelto, Jesús, Pelletier, Maude, Arnaud, Laurent, and Picard, Ghislain
- Abstract
Expanding shrubs in the Arctic trap blowing snow, increasing snow height and accelerating permafrost warming. Topography also affects snow height as snow accumulates in hollows. The respective roles of topography and erect vegetation in snow accumulation were investigated using a UAV-borne lidar at two nearby contrasted sites in northern Quebec, Canada. The North site featured tall vegetation up to 2.5 m high, moderate snow height, and smooth topography. The South site featured lower vegetation, greater snow height, and rougher topography. There was little correlation between topography and vegetation height at both sites. Vegetation lower than snow height had very little effect on snow height. When vegetation protruded above the snow, snow height was well correlated with vegetation height. The topographic position index (TPI) was well correlated with snow height when it was not masked by the effect of protruding vegetation. The North site with taller vegetation therefore showed a good correlation between vegetation height and snow height, R2 = 0.37, versus R2 = 0.04 at the South site. Regarding topography, the reverse was observed between TPI and snow height, with R2 = 0.29 at the North site and R2 = 0.67 at the South site. The combination of vegetation height and TPI improved the prediction of snow height at the North site (R2 = 0.59) but not at the South site because vegetation height has little influence there. Vegetation was therefore the main factor determining snow height when it protruded above the snow. When it did not protrude, snow height was mostly determined by topography., [Significance Statement] Wind-induced snow drifting is a major snow redistribution process in the Arctic. Shrubs trap drifting snow, and drifting snow accumulates in hollows. Determining the respective roles of both these processes in snow accumulation is required to predict permafrost temperature and its emission of greenhouse gases, because thicker snow limits permafrost winter cooling. Using a UAV-borne lidar, we have determined snow height distribution over two contrasted sites in the Canadian low Arctic, with varied vegetation height and topography. When snow height exceeds vegetation height, topography is a good predictor of snow height, with negligible effect of buried vegetation. When vegetation protrudes above the snow, combining both topography and vegetation height is required for a good prediction of snow height.
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- 2023
128. Bromine, iodine and sodium along the EAIIST traverse: Bulk and surface snow latitudinal variability
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Programma Nazionale di Ricerche in Antartide, Agence Nationale de la Recherche (France), BNP Paribas, Institut Polaire Français Paul Emile Victor, Celli, G. [0000-0001-5526-7472], Scarchilli, C. [0000-0002-2414-2439], Cuevas, Carlos A. [0000-0002-9251-5460], Savarino, J. [0000-0002-6708-9623], Stenni, B. [0000-0003-4950-3664], Frezzotti, M. [0000-0002-2461-2883], Becagli, S. [0000-0003-3633-4849], Angot, H. [0000-0003-4673-8249], Spolaor, A. [0000-0001-8635-9193], Celli, G., Cairns, W. R. L., Scarchilli, C., Cuevas, Carlos A., Saiz-Lopez, A., Savarino, J., Stenni, B., Frezzotti, M., Becagli, S., Delmonte, B., Angot, H., Fernandez, R. P., Spolaor, A., Programma Nazionale di Ricerche in Antartide, Agence Nationale de la Recherche (France), BNP Paribas, Institut Polaire Français Paul Emile Victor, Celli, G. [0000-0001-5526-7472], Scarchilli, C. [0000-0002-2414-2439], Cuevas, Carlos A. [0000-0002-9251-5460], Savarino, J. [0000-0002-6708-9623], Stenni, B. [0000-0003-4950-3664], Frezzotti, M. [0000-0002-2461-2883], Becagli, S. [0000-0003-3633-4849], Angot, H. [0000-0003-4673-8249], Spolaor, A. [0000-0001-8635-9193], Celli, G., Cairns, W. R. L., Scarchilli, C., Cuevas, Carlos A., Saiz-Lopez, A., Savarino, J., Stenni, B., Frezzotti, M., Becagli, S., Delmonte, B., Angot, H., Fernandez, R. P., and Spolaor, A.
- Abstract
During the East Antarctic International Ice Sheet Traverse (Eaiist, december 2019), in an unexplored part of the East Antarctic Plateau, snow samples were collected to expand our knowledge of the latitudinal variability of iodine, bromine and sodium as well as their relation in connection with emission processes and photochemical activation in this unexplored area. A total of 32 surface (0-5 cm) and 32 bulk (average of 1 m depth) samples were taken and analysed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Our results show that there is no relevant latitudinal trend for bromine and sodium. For bromine they also show that it has no significant post-depositional mechanisms while its inland surface snow concentration is influenced by spring coastal bromine explosions. Iodine concentrations are several orders of magnitude lower than bromine and sodium and they show a decreasing trend in the surface samples concentration moving southward. This suggests that other processes affect its accumulation in surface snow, probably related to the radial reduction in the ozone layer moving towards central Antarctica. Even though all iodine, bromine and sodium present similar long-range transport from the dominant coastal Antarctic sources, the annual seasonal cycle of the ozone hole over Antarctica increases the amount of UV radiation (in the 280-320 nm range) reaching the surface, thereby affecting the surface snow photoactivation of iodine. A comparison between the bulk and surface samples supports the conclusion that iodine undergoes spring and summer snow recycling that increases its atmospheric lifetime, while it tends to accumulate during the winter months when photochemistry ceases.
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- 2023
129. The deep vault: a temporary refuge for temperate gorgonian forests facing marine heat waves
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BNP Paribas, European Commission, Università di Cagliari, Office français de la biodiversité (France), Labex Cemeb, Agencia Estatal de Investigación (España), Bramanti, Lorenzo, Manea, Elisabetta, Giordano, Bruna, Estaque, Tristan, Bianchimani, Olivier, Richaume, Justine, Mérigot, Bastien, Schull, Quentin, Sartoretto, Stéphane, Garrabou, Joaquim, Guizien, Katell, BNP Paribas, European Commission, Università di Cagliari, Office français de la biodiversité (France), Labex Cemeb, Agencia Estatal de Investigación (España), Bramanti, Lorenzo, Manea, Elisabetta, Giordano, Bruna, Estaque, Tristan, Bianchimani, Olivier, Richaume, Justine, Mérigot, Bastien, Schull, Quentin, Sartoretto, Stéphane, Garrabou, Joaquim, and Guizien, Katell
- Abstract
Climate change poses a significant threat to coastal areas, marked by the increasing intensity and frequency of marine heat waves observed in various ecosystems around the world. Over the last 25 years, a vast number of Mediterranean populations of the red gorgonian Paramuricea clavata have been impacted by marine heatwaves. The last mass mortality occurred during the summer of 2022 in the Western Mediterranean Sea, affecting mostly shallow populations (down to 30 m depth). Here we provide an assessment of the health status of mesophotic P. clavata populations down to 90 m depth to investigate a depth refuge hypothesis. Results show that the impact of marine heat waves decreases with depth, with a significant drop in mortality below 40 m depth. These observations support the hypothesis of a depth refuge from marine heat waves that may allow, at least temporarily, the maintenance of P. clavata in the Western Mediterranean Sea. The present study strongly advocates for further investigations and monitoring of the mesophotic zone to chart potential areas that could serve as deep refuge for gorgonians
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- 2023
130. Characterization of sequentially-staged cancer cells using electrorotation.
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Claudia I Trainito, Daniel C Sweeney, Jaka Čemažar, Eva M Schmelz, Olivier Français, Bruno Le Pioufle, and Rafael V Davalos
- Subjects
Medicine ,Science - Abstract
The identification and separation of cells from heterogeneous populations is critical to the diagnosis of diseases. Label-free methodologies in particular have been developed to manipulate individual cells using properties such as density and morphology. The electrical properties of malignant cells, including the membrane capacitance and cytoplasmic conductivity, have been demonstrated to be altered compared to non-malignant cells of similar origin. Here, we exploit these changes to characterize individual cells in a sequentially-staged in vitro cancer model using electrorotation (EROT)-the rotation of a cell induced by a rotating electric field. Using a microfabricated device, a dielectrophoretic force to suspend cells while measuring their angular velocity resulting from an EROT force applied at frequencies between 3 kHz to 10 MHz. We experimentally determine the EROT response for cells at three stages of malignancy and analyze the resultant spectra by considering models that include the effect of the cell membrane alone (single-shell model) and the combined effect of the cell membrane and nucleus (double-shell model). We find that the cell membrane is largely responsible for a given cell's EROT response between 3 kHz and 10 MHz. Our results also indicate that membrane capacitance, membrane conductance, and cytoplasmic conductivity increase with an increasingly malignant phenotype. Our results demonstrate the potential of using electrorotation as a means making of non-invasive measurements to characterize the dielectric properties of cancer cells.
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- 2019
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131. Microdevice for studying the in situ permeabilization and characterization of Chlamydomonas reinhardtii in lipid accumulation phase
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Bodénès, P., Lopes, F., Pareau, D., Français, O., and Le Pioufle, B.
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- 2016
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- View/download PDF
132. RF Characterization of Intracellular Microalgae Lipids
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Fellahi, A. El, Bore, T., Bodenes, P., Bensalem, S., Le Pioufle, B., Lopes, F., Martincic, E., and Français, O.
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- 2016
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- View/download PDF
133. Nanoparticle Electrical Analysis and Detection with a Solid-state Nanopore in a Microfluidic Device
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Roman, Jean, Français, Olivier, Jarroux, Nathalie, Patriarche, Gilles, Pelta, Juan, Le Pioufle, Bruno, and Bacri, Laurent
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- 2016
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134. Perioperative Coagulation Management in Cardiac Surgery. (ROTEM)
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Laboratoire français de Fractionnement et de Biotechnologies and Karine Nubret-Le coniat
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- 2011
135. REPI : a Randomized Open Label Trial Evaluating the Use of APC in Pre-Implantation Reconstruction of Maxilla
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Etablissement Français du Sang
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- 2008
136. Study of an Early Change of a Chemotherapeutic Doublet Versus Four Cycles of Chemotherapy in Advanced Non Small Cell Lung Cancer
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Groupe Français de Pneumologie Cancérologie (GFPC)
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- 2007
137. Autoantibodies against type I IFNs in patients with critical influenza pneumonia
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Zhang, Qian, Pizzorno, Andrés, Miorin, Lisa, Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Bizien, Lucy, Manry, Jeremy, Rosain, Jérémie, Philippot, Quentin, Goavec, Kelian, Wroblewski, Isabelle, Husebye, Eystein, Fellay, Jacques, Pothier, Pierre, Morand, Patrice, Navarrete, Nicolás, Franco, José Luis, Uddin, Mohammed J., Carratalà, Jordi, Merino Díaz, Laura, Palomo, Virginia, Seppänen, Mikko R.J., Särekannu, Karita, Aiuti, Alessandro, Retamar Gentil, Pilar, Debette, Stéphanie, Belot, Alexandre, Abel, Laurent, Soler Palacín, Pere, Abad Arranz, Maria, Aguilar Guisado, Manuela, Meyts, Isabelle, Casanova, Jean-Laurent, Gonzalez Granado, Luis L., Butte, Manish J., Itan, Yuval, Escoresca Ortega, Ana, Morio, Tomohiro, Padey, Blandine, Niubó, Jordi, Gallardo Ríos, Rafaela, Lau, Yu-lung, Triantafyllia, Vasiliki, Briones, Marisa, Saker, Kahina, Richard, Pascale, Drolet, Beth A., Espinosa Padilla, Sara, Wauters, Joost, Peigue Lafeuille, Helene, Valiente, Adoración, El Baghdadi, Jamila, Tiberghien, Pierre, Balsera-manzanero, María, Zins, Marie, Hammarström, Lennart, Andreakos, Evangelos, Notarangelo, Luigi D., Prando, Carolina, Condino-neto, Antonio, Dominguez Pinilla, Nerea, Aydillo, Teresa, Okamoto, Keisuke, Soumaré, Aïcha, Karamitros, Timokratis, Medina, Rafael A., Kisand, Kai, Ramírez Duque, Nieves, Feys, Simon, Romero Oraa, Laura, Kuo, Chen-yen, Lei, Wei-te, Quintana Murci, Lluis, Milner, Joshua D., Ku, Cheng-lung, Van De Beek, Diederik, Hsieh, Elena W.Y., Tal, Galit, Fournet, Thomas, Cerba Healthcare Group, Patural, Hugues, Novelli, Giuseppe, Lyon Antigrippe Working Group, Arias, Andrés A., Rovina, Nikoletta, Rodríguez-gallego, Carlos, Puel, Anne, Jouanguy, Emmanuelle, Vinh, Donald C., Henny, Joseph, Mogensen, Trine H., Cobat, Aurélie, Casari, Giorgio, Ramaswamy, Sathishkumar, Abelenda Alonso, Gabriela, Morel, Pascal, Trouillet Assant, Sophie, Tzourio, Christophe, Gallian, Pierre, Reipi Inf Working Group, García Sastre, Adolfo, Constantinescu, Stefan N., Hamzeh Cognasse, Hind, Haerynck, Filomeen, Flores, Carlos, Bousfiha, Ahmed A., García Salum, Tamara, Shahrooei, Mohammed, Slaby, Ondrej, Fragkou, Paraskevi C., Argaud, Laurent, Shcherbina, Anna, Al-muhsen, Saleh, Biggs, Catherine M., Bogunovic, Dusan, Planas, Anna M., Heath, James R., Von Bernuth, Horst, Dufouil, Carole, Bolze, Alexandre, Boeuf, Benoit, Rodríguez Gallego, Carlos, Christodoulou, John, Bondarenko, Anastasiia, Martin, Fernando, Koltsida, Ourania, Sediva, Anna, Ruiz Hernandez, José Juan, Bonneaudeau, Brigitte, Cannet, Dorothée, Etablissement Français Du Sang Study Group, Froidure, Antoine, Laurent, Emilie, Galani, Ioanna Evdokia, Gregersen, Peter K., Lemonnier, Sylvie, Spaan, András N., Darmon, Michael, Grimbacher, Bodo, Del Mar Muñoz Garcia, Maria, Zawadzki, Pawel, Henrickson, Sarah E., O'farrelly, Cliona, Rosa Calatrava, Manuel, Lachaize, Morgane, Okada, Satoshi, Vanker, Martti, Bryceson, Yenan, Ling, Yun, Cooper, Megan A., Lucas, Carrie L., Maniatis, Tom, Romero Vázquez, Gloria María, Mansouri, Davood, Castagnoli, Riccardo, Maródi, László, Mironska, Kristina, Rapti, Vasiliki, Baris Feldman, Hagit, Pozzetto, Bruno, Renia, Laurent, Tancevski, Ivan, Imai, Kohsuke, Ozcelik, Tayfun, Pan-hammarström, Qiang, Al-mulla, Fahd, Pape, Jean W., Etzioni, Amos, Souweine, Bertrand, Perez De Diego, Rebeca, Sánchez Cordero, Maria Jose, Solé Violán, Jordi, Perlin, David S., Queromes, Gregory, Anderson, Mark S., Resnick, Igor, Pesole, Graziano, Su, Helen C., Vanderbeke, Lore, Hagin, David, Jeanne, Michel, Desai, Murkesh, Ferres, Marcela, Sánchez Céspedes, Javier, Perroquin, Magali, Ng, Lisa F.P., Abou Tayoun, Ahmad, Le Corre, Nicole, Snow, Andrew L., Temel, Şehime Gülsün, Tsiodras, Sotirios, Coeuret Pellicer, Mireille, Javouhey, Etienne, Turvey, Stuart E., Covid Human Genetic Effort, Rombauts, Alexander, Zatz, Mayana, Uddin, K.m. Furkan, Fievet, Nathalie, Jarvis, Erich D., Rodríguez De Castro, Felipe, Ferreres, José, Flaig, Amandine, Pujol, Aurora, Cognasse, Fabrice, Sancho Shimizu, Vanessa, Nadif, Rachel, Hanna, Suhair, Constances Cohort, Goldberg, Marcel, Brodin, Petter, Le Got, Stéphane, Ozguler, Anna, Quenot, Jean Pierre, Novelli, Antonio, Cordero, Elisa, Colomb, Benoit, Cupic, Anastasija, Mehlal Sedkaoui, Souad, Sallette, Jérôme, Hernu, Romain, Bustamante, Carlos D., Lina, Bruno, Halwani, Rabih, Casalegno, Jean Sebastien, Schwebel, Carole, Salamanca Rivera, Celia, 3C-Dijon Study, Tangye, Stuart G., Dalgard, Clifton L., Howard Hughes Medical Institute, Rockefeller University, St. Giles Foundation, National Institutes of Health (US), National Center for Advancing Translational Sciences (US), Fisher Center for Alzheimer's Research Foundation, Meyer Foundation, JPB Foundation, Agence Nationale de la Recherche (France), European Commission, Square Foundation, Ministre de l'Enseignement Supérieur, de la Recherche et de l'Innovation (France), Institut National de la Santé et de la Recherche Médicale (France), Université Paris Cité, Center for Research for Influenza Pathogenesis (US), National Institute of Allergy and Infectious Diseases (US), Center of Excellence for Influenza Research and Response (US) CEIRR, Agencia Nacional de Investigación y Desarrollo (Chile), Centre National de la Recherche Scientifique (France), Ministère des Solidarités et de la Santé (France), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Sociedad Española de Neumología y Cirugía Torácica, Cabildo de Tenerife, Hellenic Foundation for Research and Innovation, Fondation pour la Recherche Médicale, Fondation Bettencourt Schueller, Ministerio de Ciencia, Innovación y Universidades (España), Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Junta de Andalucía, Research Foundation - Flanders, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang [La Plaine Saint-Denis] (EFS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Biotechnologie et Microbiologie Appliquée (LBMA), Université Bordeaux Segalen - Bordeaux 2-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR - laboratoire associé), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), 01057100, HORIZON-HLTH-2021-DISEASE-04, MESRI-COVID-19, ANR-10-LABX-62-IBEID, P18-RT-3320, CGIEU0000219140, RTC-2017-6471-1, REIPI RD16/0016/0009, National Institutes of Health, NIH: R01AI088364, R01AI163029, Howard Hughes Medical Institute, HHMI, National Institute of Allergy and Infectious Diseases, NIAID: 75N93021C00014, U19AI135972, U19AI142733, U19AI168631, Jeffrey Modell Foundation, JMF, Glenn Foundation for Medical Research, GFMR: ANRS-COV05, EA20170638020, EQU201903007798, Pfizer, Albert Ellis Institute, AEI, National Center for Advancing Translational Sciences, NCATS: UL1 TR001866, JPB Foundation, JPBF, Horizon 2020 Framework Programme, H2020: 824110, Fondation du Souffle, FdS, College of Natural Resources and Sciences, Humboldt State University, CNRS, Ministerio de Ciencia, Innovación y Universidades, MCIU, Instituto Tecnológico y de Energías Renovables, ITER, SCOR Corporate Foundation for Science, Agence Nationale de la Recherche, ANR: ANR-10-IAHU-01, Institut National de la Santé et de la Recherche Médicale, Inserm, Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT: 1161971, 1212023, Association Nationale de la Recherche et de la Technologie, ANRT, Fonds Wetenschappelijk Onderzoek, FWO: G0B5120N, G0C8517N, G0E8420N, KU Leuven: C16/18/007, Instituto de Salud Carlos III, ISCIII: COV20_01333, COV20_01334, PI12/01565, European Regional Development Fund, ERDF: CB21/13/00006, University of the East, UE, Hellenic Foundation for Research and Innovation, ΕΛ.ΙΔ.Ε.Κ, Université de Paris, SINOVAC outside the submitted work. P. Retamar-Gentil reported personal fees from Merck outside the submitted work. I. Meyts reported grants from CSL-Behring outside the submitted work. E. Andreakos reported grants from Janssen Pharmaceuticals during the conduct of the study. J. Wauters reported grants and personal fees from Pfizer and Gilead outside the submitted work. L. Vanderbeke reported grants from Research Foundation Flanders and non-financial support from Pfizer outside the submitted work. S. Feys reported grants from Pfizer outside the submitted work. J. Casalegno reported 'other' from Pfizer and grants from Sanofi outside the submitted work. M. Rosa-Calatrava reported a patent to WO2016/146836 licensed (Signia Therapeutics), a patent to WO2017/174593 licensed (Signia Therapeutics), and a patent to WO2019/224489 licensed (Signia Therapeutics), and is the co-founder of Signia Therapeutics SAS. S. Trouillet-Assant reported non-financial support from BioMérieux outside the submitted work. A. Garcia-Sastre reported 'other' from Vivaldi Biosciences, Pagoda, Contrafect, Vaxalto, Accurius, Curelab oncology, and Curelab veterinary, personal fees from Avimex, 7Hills, Esperovax, Pfizer, Farmak, Applied Biological Laboratories, Paratus, Pharmamar, Pfizer, and Synairgen, grants from Pfizer, Pharmamar, Blade Therapeutics, Avimex, Accurius, Dyna-vax, Kenall Manufacturing, ImmunityBio, Nanocomposix, Merck, Model Medicines, Atea Pharma, Shenwa Biosciences, Johnson & Johnson, 7 Hills, Hexamer, N-fold LLC, and Applied Biological Laboratories outside the submitted work, in addition, A. Garcia-Sastre had a patent for influenza virus vaccines and uses thereof issued, and invited speaker in meeting events organized by Seqirus, Janssen, Abbott, and Astrazeneca. J. Casanova reported a patent to PCT/US2021/ 042741 pending. No other disclosures were reported., We thank Dr. Cato Jacobs for her contribution to the sampling of UZLeuven patients in Belgium. The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH, R01AI088364 and R01AI163029), the National Center for Advancing Translational Sciences, NIH Clinical and Translational Science Award program (UL1 TR001866), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JPB Foundation, the French National Research Agency (ANR) under the 'Investments for the Future' program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (EQU201903007798), the ANRS-COV05, ANR-RHU program ANR-21-RHUS-08, ANR GENVIR (ANR-20-CE93-003), ANR GenMISC (ANR-21-COVR-0039), and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the European Union’s Horizon 2020 research and innovation program under grant agreement 824110 (EASI-genomics), the HORIZON-HLTH-2021-DISEASE-04 program under grant agreement 01057100 (UNDINE), the Square Foundation, Grandir–Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Sci-ence, the French Ministry of Higher Education, Research, and Innovation (MESRI-COVID-19), Institut National de la Santé et de la Recherche Médicale (INSERM), REACTing-INSERM, and the Université Paris Cité. This work was partly supported by the Center for Research on Influenza Pathogenesis and Transmis-sion, a National Institute of Allergy and Infectious Diseases (NIAID)–funded Center of Excellence for Influenza Research and Response (contract no. 75N93021C00014), and the FLUOMICS Consortium (NIH-NIAID grant U19AI135972) to both A. García-Sastre and R.A. Medina, and by NIAID grant U19AI142733 and U19AI168631 to A. García-Sastre. Work in the Medina laboratory was also supported by the PIA ACT 1408, FONDECYT 1161971 and 1212023 grants from Agencia Nacional de Investigación y De-sarrollo of Chile. The VirPath team is supported by INSERM REACTing (Research & Action Emerging Infectious Diseases), CNRS, and Mérieux Research grants. B. Padey is supported by an ANRT CIFRE PhD scholarship. For the Lyon cohort, specimen collection and study was supported by a grant from the French Ministry of Health PHRC-I 2013 ANTIGRIPPE. C. Rodríguez-Gallego and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333, COV20_01334, and PI12/01565, Spanish Ministry for Science and Innovation RTC-2017-6471-1, AEI/ FEDER, UE), Grupo DISA, Fundación MAPFRE Guanarteme, Sociedad Española de Neumología y Cirugía Torácica and Cab-ildo Insular de Tenerife (CGIEU0000219140 and 'Apuestas, científicas del Instituto Tecnológico y de Energías Renovables para colaborar en la lucha contra la COVID-19'). E. Andreakos is supported by the Hellenic Foundation for Research and Innovation (INTERFLU, no. 1574). P. Bastard was supported by the French Foundation for Medical Research (EA20170638020) and by the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). This study was supported by Plan Nacional de I+D+i 2013-2016 and In-stituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0009), cofinanced by European Regional Development Fund 'A way to achieve Eu-rope', Operative Program Intelligence Growth 2014-2020 (CB21/13/00006) also was supported by CIBER-Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea–Next Generation EU and Consejería de Economía, Conocimiento, Empresas y Universidad, Secretaría General de Universidades, Investigación y Tecnología, Junta de Andalucía, Spain (P18-RT-3320). I. Meyts is a Senior Clinical Investigator at the Research Foundation–Flanders and is supported by the CSL Behring Chair of Primary Immunodeficiencies, a CSL-Behring Research Grant, KU Leuven C1 grant C16/18/007, a VIB GC PID Grant, Fonds Wetenschappelijk Onderzoek grants G0C8517N, G0B5120N, and G0E8420N, and the Jeffrey Modell Foundation. Open Access funding provided by Rockefeller University. Author contributions: Q. Zhang, A. Pizzorno, L. Miorin, P., The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH, R01AI088364 and R01AI163029), the National Center for Advancing Translational Sciences, NIH Clinical and Translational Science Award program (UL1 TR001866), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JPB Foundation, the French National Research Agency (ANR) under the 'Investments for the Future' program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (EQU201903007798), the ANRS-COV05, ANR-RHU program ANR-21-RHUS-08, ANR GENVIR (ANR-20-CE93-003), ANR GenMISC (ANR-21-COVR-0039), and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the European Union’s Horizon 2020 research and innovation program under grant agreement 824110 (EASI-genomics), the HORIZON-HLTH-2021-DISEASE-04 program under grant agreement 01057100 (UNDINE), the Square Foundation, Grandir–Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, the French Ministry of Higher Education, Research, and Innovation (MESRI-COVID-19), Institut National de la Santé et de la Recherche Médicale (INSERM), REACTing-INSERM, and the Université Paris Cité. This work was partly supported by the Center for Research on Influenza Pathogenesis and Transmission, a National Institute of Allergy and Infectious Diseases (NIAID)–funded Center of Excellence for Influenza Research and Response (contract no. 75N93021C00014), and the FLUOMICS Consortium (NIH-NIAID grant U19AI135972) to both A. García-Sastre and R.A. Medina, and by NIAID grant U19AI142733 and U19AI168631 to A. García-Sastre. Work in the Medina laboratory was also supported by the PIA ACT 1408, FONDECYT 1161971 and 1212023 grants from Agencia Nacional de Investigación y De-sarrollo of Chile. The VirPath team is supported by INSERM REACTing (Research & Action Emerging Infectious Diseases), CNRS, and Mérieux Research grants. B. Padey is supported by an ANRT CIFRE PhD scholarship. For the Lyon cohort, specimen collection and study was supported by a grant from the French Ministry of Health PHRC-I 2013 ANTIGRIPPE. C. Rodríguez-Gallego and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333, COV20_01334, and PI12/01565, Spanish Ministry for Science and Innovation RTC-2017-6471-1, AEI/ FEDER, UE), Grupo DISA, Fundación MAPFRE Guanarteme, Sociedad Española de Neumología y Cirugía Torácica and Cabildo Insular de Tenerife (CGIEU0000219140 and 'Apuestas, científicas del Instituto Tecnológico y de Energías Renovables para colaborar en la lucha contra la COVID-19'). E. Andreakos is supported by the Hellenic Foundation for Research and, Innovation (INTERFLU, no. 1574). P. Bastard was supported by the French Foundation for Medical Research (EA20170638020) and by the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). This study was supported by Plan Nacional de I+D+i 2013-2016 and In-stituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0009), cofinanced by European Regional Development Fund 'A way to achieve Europe', Operative Program Intelligence Growth 2014-2020 (CB21/13/00006) also was supported by CIBER-Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea–Next Generation EU and Consejería de Economía, Conocimiento, Empresas y Universidad, Secretaría General de Universidades, Investigación y Tecnología, Junta de Andalucía, Spain (P18-RT-3320). I. Meyts is a Senior Clinical Investigator at the Research Foundation–Flanders and is supported by the CSL Behring Chair of Primary Immunodeficiencies, a CSL-Behring Research Grant, KU Leuven C1 grant C16/18/007, a VIB GC PID Grant, Fonds Wetenschappelijk Onderzoek grants G0C8517N, G0B5120N, and G0E8420N, and the Jeffrey Modell Foundation. Open Access funding provided by Rockefeller University., ANR-20-CO11-0001,AABIFNCOV,Bases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19.(2020), ANR-20-CE93-0003,GENVIR,Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères(2020), ANR-21-COVR-0039,GenMIS-C,Recherche des Déficits immunitaires innées monogéniques prédisposant au syndrome inflammatoire multisystémique chez l'enfant.(2021), and ANR-21-RHUS-0008,COVIFERON,Covid-19 and interferons: from discovery to therapy(2021)
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INTERFERON ,Cerba HealthCare Group ,Immunology ,SEVERE COVID-19 ,Pneumònia ,Autoanticossos ,DETERMINANTS ,IMMUNITY ,Grip ,NEUTRALIZING ANTIBODIES ,3C-Dijon Study ,INFECTION ,Influenza, Human ,Medicine and Health Sciences ,Immunology and Allergy ,Humans ,COVID Human Genetic Effort ,MYASTHENIA-GRAVIS PATIENTS ,Autoantibodies ,REIPI INF Working Group ,Etablissement Français du Sang Study Group ,Yellow Fever Vaccine ,COVID-19 ,Pneumonia ,ALLELES ,Lyon Antigrippe Working Group ,Influenza ,ALPHA ,Settore MED/03 ,Interferon Type I ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,BURDEN ,Constances Cohort - Abstract
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients 70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 × 10-5), especially those, The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH; R01AI088364 and R01AI163029), the National Center for Advancing Translational Sciences, NIH Clinical and Translational Science Award program (UL1 TR001866), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JPB Foundation, the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (EQU201903007798), the ANRS-COV05, ANR-RHU program ANR-21-RHUS-08, ANR GENVIR (ANR-20-CE93-003), ANR GenMISC (ANR-21-COVR-0039), and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the European Union’s Horizon 2020 research and innovation program under grant agreement 824110 (EASI-genomics), the HORIZON-HLTH-2021-DISEASE-04 program under grant agreement 01057100 (UNDINE), the Square Foundation, Grandir–Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, the French Ministry of Higher Education, Research, and Innovation (MESRI-COVID-19), Institut National de la Santé et de la Recherche Médicale (INSERM), REACTing-INSERM, and the Université Paris Cité. This work was partly supported by the Center for Research on Influenza Pathogenesis and Transmission, a National Institute of Allergy and Infectious Diseases (NIAID)–funded Center of Excellence for Influenza Research and Response (contract no. 75N93021C00014), and the FLUOMICS Consortium (NIH-NIAID grant U19AI135972) to both A. García-Sastre and R.A. Medina, and by NIAID grant U19AI142733 and U19AI168631 to A. García-Sastre. Work in the Medina laboratory was also supported by the PIA ACT 1408, FONDECYT 1161971 and 1212023 grants from Agencia Nacional de Investigación y Desarrollo of Chile. The VirPath team is supported by INSERM REACTing (Research & Action Emerging Infectious Diseases), CNRS, and Mérieux Research grants. B. Padey is supported by an ANRT CIFRE PhD scholarship. For the Lyon cohort, specimen collection and study was supported by a grant from the French Ministry of Health PHRC-I 2013 ANTIGRIPPE. C. Rodríguez-Gallego and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333, COV20_01334, and PI12/01565, Spanish Ministry for Science and Innovation RTC-2017-6471-1; AEI/FEDER, UE), Grupo DISA, Fundación MAPFRE Guanarteme, Sociedad Española de Neumología y Cirugía Torácica and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas, científicas del Instituto Tecnológico y de Energías Renovables para colaborar en la lucha contra la COVID-19”). E. Andreakos is supported by the Hellenic Foundation for Research and Innovation (INTERFLU, no. 1574). P. Bastard was supported by the French Foundation for Medical Research (EA20170638020) and by the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). This study was supported by Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0009); cofinanced by European Regional Development Fund “A way to achieve Europe”; Operative Program Intelligence Growth 2014-2020 (CB21/13/00006) also was supported by CIBER-Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea–Next Generation EU and Consejería de Economía, Conocimiento, Empresas y Universidad, Secretaría General de Universidades, Investigación y Tecnología, Junta de Andalucía, Spain (P18-RT-3320). I. Meyts is a Senior Clinical Investigator at the Research Foundation–Flanders and is supported by the CSL Behring Chair of Primary Immunodeficiencies, a CSL-Behring Research Grant, KU Leuven C1 grant C16/18/007, a VIB GC PID Grant, Fonds Wetenschappelijk Onderzoek grants G0C8517N, G0B5120N, and G0E8420N, and the Jeffrey Modell Foundation. Open Access funding provided by Rockefeller University.
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138. Endophthalmitis After Intravitreal Injections: Incidence, Presentation, Management, and Visual Outcome
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Berthon, Laurent, Maftouhi, Quaranta-El, Bakhti, Amina, Conrath, John, Le Mer, Yannick, Ramahefasolo, Christiane Besse, Coscas, Florence, Français, Catherine, Grenet, Typhaine, Cohen, Salomon Yves, Uzzan, Joël, Razavi, Sam, Saleh, Maher, Delbosc, Bernard, Chaine, Gilles, Fajnkuchen, Franck, Giocanti, Audrey, Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Querques, Giuseppe, Chevreaud, Olivier, Souied, Eric, Musson, Cécile, Chiquet, Christophe, Fortoul, Vincent, Kodjikian, Laurent, Straub, Morgane, Burillon, Carole, Berrod, Jean-Paul, Baillif, Stéphanie, Girmens, Jean-François, Pérol, Julien, Leveziel, Nicolas, Boissonnot, Michèle, Muraine, Marc, Gaucher, David, Le Lez, Marie-Laure, Pisella, Pierre-Jean, Dossarps, Denis, Bron, Alain M., Koehrer, Philippe, Aho-Glélé, Ludwig S., and Creuzot-Garcher, Catherine
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- 2015
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139. Study of the Effectiveness of Rituximab in Adults With Chronic and Severe Immune Thrombocytopenic Purpura and Candidate for a Splenectomy
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Etablissement Français du Sang
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- 2005
140. A generic and label free method based on dielectrophoresis for the continuous separation of microorganism from whole blood samples
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Bisceglia, Emilie, Cubizolles, Myriam, Trainito, Claudia Irene, Berthier, Jean, Pudda, Catherine, Français, Olivier, Mallard, Frédéric, and Le Pioufle, Bruno
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- 2015
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141. Analysis of pulsed electric field effects on cellular tissue with Cole–Cole model: Monitoring permeabilization under inhomogeneous electrical field with bioimpedance parameter variations
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Trainito, C.I., Français, O., and Le Pioufle, B.
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- 2015
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142. IFREMER - EMODnet Chemistry Questionnaire regarding QA/QC procedures - 2022
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IFREMER-Institut Français De Recherche Pour L'Exploitation De La Mer
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Questionnaire regarding QA/QC procedures - Abstract
EMODnet Chemistry Questionnaire to collect, from data originators, information regarding QA/QC procedures for seawater, biota, and sediment samples
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- 2023
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143. Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission
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Adrie, Christophe, Lugosi, Maxime, Sonneville, Romain, Souweine, Bertrand, Ruckly, Stéphane, Cartier, Jean-Charles, Garrouste-Orgeas, Maité, Schwebel, Carole, Timsit, Jean-François, Timsit, Jean-François, Azoulay, Elie, Cohen, Yves, Garrouste-Orgeas, Maïté, Soufir, Lilia, Zahar, Jean-Ralph, Adrie, Christophe, Darmon, Michael, Alberti, Corinne, Clec’h, Christophe, Français, Adrien, Vesin, Aurélien, Ruckly, Stephane, Lecorre, Frederik, Nakache, Didier, Vannieuwenhuyze, Aurélien, Allaouchiche, Bernard, Ara-Somohano, Claire, Argault, Laurent, Bonadona, Agnès, Bornstain, Caroline, Bouadma, Lila, Boyer, Alexandre, Cheval, Christine, Colin, Jean-Pierre, Dumenil, Anne-Sylvie, Descorps-Declere, Adrien, Fosse, Jean-Philippe, Hamidfar-Roy, Rebecca, Jamali, Samir, Khallel, Hatem, Laplace, Christian, Lautrette, Alexandre, Lazard, Thierry, Le Miere, Eric, Lugosi, Maxime, Marcotte, Guillaume, Montesino, Laurent, Mourvillier, Bruno, Misset, Benoît, Moreau, Delphine, Pigné, Etienne, Ruckly, Stéphane, Souweine, Bertrand, Schwebel, Carole, Troché, Gilles, Thuong, Marie, Thierry, Guillaume, Toledano, Dany, Vantalon, Eric, Tournegros, Caroline, Ferrand, Loïc, Kaddour, Nadira, Berthe, Boris, Mellouk, Kaouttar, Deiler, Veronique, Tiercelet, Kelly, Letrou, Sophie, Théodose, Igor, Fournier, Julien, and On behalf of the OUTCOMEREA study group
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- 2017
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144. High Density Cell Electrofusion on Chip using an Array of Non-connected Metallic Pads.
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Feriel Hamdi, Wei Wang, Frédéric Subra, Elisabeth Dufour-Gergam, Olivier Français, and Bruno Le Pioufle
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- 2013
145. Positioning and Orientation of Adherent Cells in a Microfluidic Chip using the Micro Patterning of a Parylene-C Film.
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Claire Dalmay, Jun-Jung Lai, Laurent Griscom, Olivier Français, Bruno Le Pioufle, Frédéric Subra, Patrick Tauc, and Joseph Lautru
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- 2011
146. Towards a Statistical Description of Experimental Data for Detection-estimation Problems in DNA Translocations through Nanopores.
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Stéphane Michelet, Jean-Pierre Barbot, Olivier Français, Pierre-Yves Joubert, Pascal Larzabal, R. Kawano, H. Sasaki, T. Osaki, S. Takeuchi, and Bruno Le Pioufle
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- 2011
147. How medium osmolarity influences dielectrophoretically assisted on-chip electrofusion
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Hamdi, Feriel Siham, Français, Olivier, Dufour-Gergam, Elisabeth, and Le Pioufle, Bruno
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- 2014
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148. A Microfluidic Device Based on Standing Surface Acoustic Waves for Sorting and Trapping Microparticles
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Mezzanzanica, Gianluca, primary, Agazzi, Luigi, additional, Siena, Martina, additional, Français, Olivier, additional, and Mariani, Stefano, additional
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- 2022
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149. Nanomanipulation of Living Cells on a Chip Using Electric Field: General Concepts and Microdevices.
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Julien Villemejane, Guillaume Mottet, Olivier Français, Bruno Le Pioufle, Jean-Pierre Lefevre, Marion Woytasik, Elisabeth Dufour-Gergam, and Lluis M. Mir
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- 2010
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150. Effects of habituation, research and ecotourism on faecal glucocorticoid metabolites in wild western lowland gorillas: Implications for conservation management
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Shutt, Kathryn, Heistermann, Michael, Kasim, Adetayo, Todd, Angelique, Kalousova, Barbora, Profosouva, Ilona, Petrzelkova, Klara, Fuh, Terrence, Dicky, Jean-Francais, Bopalanzognako, Jean-Bruno, and Setchell, Joanna M.
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- 2014
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