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529 results on '"Fowler Richard"'

104. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

Author

Kanagalaghatta R. Rajashankar, K. Conners, S. Emtage, Sean Buchanan, William B. Guggino, Philip Thomas, Patrick H. Thibodeau, John F. Hunt, Wayne A. Hendrickson, Xun Zhao, Don Lorimer, Hal A. Lewis, Michael R. Dorwart, Margaret C. Kearins, Marie Zhang, Kai W. Post, Fowler Richard, Xia Gao, J. Michael Sauder, Peter C. Maloney, Stephen K. Burley, Mark Dickey, Marc E. Rutter, and Stephanie Shriver

Subjects
Models, Molecular, Molecular Sequence Data, Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding cassette transporter, Biology, Crystallography, X-Ray, General Biochemistry, Genetics and Molecular Biology, Article, chemistry.chemical_compound, Mice, Protein structure, Adenosine Triphosphate, Animals, Amino Acid Sequence, Binding site, Phosphorylation, Molecular Biology, Binding Sites, General Immunology and Microbiology, General Neuroscience, Ligand (biochemistry), Cystic fibrosis transmembrane conductance regulator, Cell biology, Protein Structure, Tertiary, Adenosine Diphosphate, Biochemistry, chemistry, Cyclic nucleotide-binding domain, Mutation, Chloride channel, biology.protein, Adenosine triphosphate, Sequence Alignment
Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette (ABC) transporter that functions as a chloride channel. Nucleotide-binding domain 1 (NBD1), one of two ABC domains in CFTR, also contains sites for the predominant CF-causing mutation and, potentially, for regulatory phosphorylation. We have determined crystal structures for mouse NBD1 in unliganded, ADP- and ATP-bound states, with and without phosphorylation. This NBD1 differs from typical ABC domains in having added regulatory segments, a foreshortened subdomain interconnection, and an unusual nucleotide conformation. Moreover, isolated NBD1 has undetectable ATPase activity and its structure is essentially the same independent of ligand state. Phe508, which is commonly deleted in CF, is exposed at a putative NBD1-transmembrane interface. Our results are consistent with a CFTR mechanism, whereby channel gating occurs through ATP binding in an NBD1–NBD2 nucleotide sandwich that forms upon displacement of NBD1 regulatory segments.

Published
2003

106. The problem with governance

Author

Fowler, Richard

Subjects
Banking, finance and accounting industries, Business
Abstract

For very real reasons, executive management tends to keep the strategic vision closely held until that strategy becomes executable. That means there are fewer eyes looking at the strategy and [...]

Published
2015

107. Root cause

Author

Fowler, Richard

Subjects
Banking, finance and accounting industries, Business
Abstract

I've been in half a dozen audit groups, and one of the best things I've learned is the '5 Cs' basis of report writing. For any issue, we need to [...]

Published
2015

108. Emerging technologies

Author

Fowler, Richard

Subjects
Banking, finance and accounting industries, Business
Abstract

New technologies will emerge, we can all be assured of that. But we can also be assured that, with rare exceptions, no company will need to study, much less embrace, [...]

Published
2015

109. Epilogue: why did we do it?

Author

Fowler, Richard

Subjects
Canadian drama -- 20th century AD, Arts, visual and performing
Abstract

PRIMUS Theatre organized the Iace Age Festival and Symposium to reinforce the idea of the theater as community and as a way of social definition both within the theater organization and in a larger social context, that of the audience, the city or the country. The theater can both define inherited reality and show alternative models of human interaction. Realizing this ideal is a major challenge in the difficult social and economic times we live in.

Published
1996

113. Ethical standards

Author

Fowler, Richard

Subjects
Banking, finance and accounting industries, Business
Abstract

We cannot hold management to a higher ethical standard than we as auditors (or CAEs) are willing to accept. If anything, the opposite is true. But it needn't be courage [...]

Published
2015

116. Bridging the Digital Divide in HIV Care

Author

Luque, Amneris E., primary, Corales, Roberto, additional, Fowler, Richard J., additional, DiMarco, Jamie, additional, van Keken, Adjuah, additional, Winters, Paul, additional, Keefer, Michael C., additional, and Fiscella, Kevin, additional

Published
2012
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120. Systems: The big kaboom

Author

Fowler, Richard

Subjects
Boating industry -- Safety and security measures, Liquefied petroleum gas -- Risk factors, Sailing -- Safety and security measures
Published
2002

124. Solid-phase gene assembly

Author

Beattie, Kenneth L. and Fowler, Richard F.

Subjects
Protein engineering -- Methods, Genetic engineering -- Methods, DNA, Environmental issues, Science and technology, Zoology and wildlife conservation
Published
1991

127. The acid tolerance response of enteropathogenic Salmonella and Escherichia coli strains : A proteomic characterisation and novel links with motility and virulence

Author

Fowler, Richard Paul. and Fowler, Richard Paul.

Abstract

This thesis concentrates on elucidating the mechanisms involved in the adaptation of exponentially growing EPEC and Salmonellai to inorganic and weak organic acids. An understanding of these mechanisms, collectively known as the acid tolerance response (ATR) is of relevance to both the food production and medicinal industries.One of the most striking findings is that flagellin, the major structural component of the bacterial flagellum, is down-regulated at pH 3.0 in acid adapted Salmonella. Further studies using reporter gene fusions indicate that the entire flagellar apparatus is transcriptionally repressed under these conditions. PhoPQ is found to mediate this mechanism, which results in a loss of cell motility, by acting directly or indirectly at the level of the flagellar fhCD master operon.One of the most striking findings is that flagellin, the major structural component of the bacterial flagellum, is down-regulated at pH 3.0 in acid adapted Salmonella. Further studies using reporter gene fusions indicate that the entire flagellar apparatus is transcriptionally repressed under these conditions. PhoPQ is found to mediate this mechanism, which results in a loss of cell motility, by acting directly or indirectly at the level of the flagellar flhCD master operon.Additional links between other virulence associated mechanisms and the ATR are also investigated. 2 ATR proteins regulated by PhoPQ are expressed similarly during the oxidative stress response. Correspondingly, survival assays indicate that an acid induced cross protection of oxidative stress in Salmonella is mediated by this global regulator. A further two regulators of pathogenesis (the BipA GTPase and the EAF plasmid) are characterised as negative regulators of the ATR in certain EPEC strains. It is concluded that ATR mechanisms are variable between different species and strains.Based on these results, it is proposed that intimate

Published
2000

128. The silky skills of a courtroom Beckham: RICHARD FOWLER

Author

Fowler, Richard

Subjects
Banking, finance and accounting industries, Business, Business, international
Abstract

The Office of Fair Trading thinks that the Queen's Counsel system may distort competition. The OFT's concerns have been set alongside reports that top silks earn Pounds 1m or more [...]

Published
2002

131. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

Author

Lewis, Hal A, primary, Buchanan, Sean G, additional, Burley, Stephen K, additional, Conners, Kris, additional, Dickey, Mark, additional, Dorwart, Michael, additional, Fowler, Richard, additional, Gao, Xia, additional, Guggino, William B, additional, Hendrickson, Wayne A, additional, Hunt, John F, additional, Kearins, Margaret C, additional, Lorimer, Don, additional, Maloney, Peter C, additional, Post, Kai W, additional, Rajashankar, Kanagalaghatta R, additional, Rutter, Marc E, additional, Sauder, J Michael, additional, Shriver, Stephanie, additional, Thibodeau, Patrick H, additional, Thomas, Philip J, additional, Zhang, Marie, additional, Zhao, Xun, additional, and Emtage, Spencer, additional

Published
2003
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134. Diffraction hardware testbed and model validation

Author

Schaechter, David B., primary, Perkins, Patrick E., additional, Mammini, Paul V., additional, Swanson, David A., additional, Tischhauser, Chris W., additional, Benson, Robert S., additional, Andersen, Torben B., additional, Bruner, Richard S., additional, Fowler, Richard I., additional, Morimoto, Kevin T., additional, and Sievers, Lisa A., additional

Published
2003
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135. TQM implementation : a conceptual study of the impact of implementation on two companies : a comparative investigation about the understanding of and impact of Total Quality Management programmes within Post Haste Couriers, Palmerston North and Rayonier New Zealand, Wellington : a thesis presented in partial fulfilment of the requirements of the degree of Master of Business Studies at Massey University

Author

Fowler, Richard John and Fowler, Richard John

Abstract

Much has been written about the concepts associated with TQM, but little exists on the impact of TQM implementation in New Zealand companies. This paper is a comparative study on the understandings and impact of TQM within two New Zealand companies, Post Haste Couriers Palmerston North and Rayonier New Zealand, Wellington. Semi structured interviews were carried out and the data compared with a variety of theoretical approaches. The findings show that TQM means different things to different levels in a companies hierarchy and its successful implementation depends on the management style, company resourcing and the amount of control that can be exercised over the business environment.

Published
1996

140. Reviews of Books

Author

Early, Frances, primary, Fowler, Richard, additional, Gorman, Vanessa B., additional, Perdue, Peter C., additional, Headley, John M., additional, Rule, John C., additional, Konnert, Mark, additional, Steele, Ian K., additional, Thornton, John, additional, Kelsey, Harry, additional, Williamson, Arthur, additional, Kishlansky, Mark A., additional, Sonnino, Paul M., additional, James, John A., additional, Bély, Lucien, additional, Calloway, Colin G., additional, Campbell, I. C., additional, Jones, Robert E., additional, Duffy, Michael, additional, Stearns, Peter N., additional, Raeff, Marc, additional, Omissi, David, additional, Quijada, Mónica, additional, Sondhaus, Lawrence, additional, Saab, Ann Pottinger, additional, Carson, Penelope, additional, Lincoln, W. Bruce, additional, Sager, Eric W., additional, Feinstein, C. H., additional, Rock, David, additional, Moses, John A., additional, Cohn, Samuel, additional, Walter, Dierk, additional, Jaireth, Subhash, additional, MacKenzie, John M., additional, Benjamin, Jules R., additional, Beckett, Ian F. W., additional, Eckes, Alfred E., additional, Cain, Peter, additional, Johnston, Hugh, additional, Winter, Jay, additional, Herwig, Holger H., additional, Lungu, Dov B., additional, Sharp, Alan, additional, Strikwerda, Carl, additional, Thompson, John A., additional, Stephanson, Anders, additional, Connolly, S. J., additional, Larson, Robert H., additional, Campbell, John P., additional, Stokes, Lawrence D., additional, Cienciala, Anna M., additional, Gullace, Nicoletta F., additional, Hayes, Geoffrey, additional, Jones, Matthew, additional, Painter, David S., additional, Bassett, Michael, additional, Singh, Anita Inder, additional, Hardt, John P., additional, Hughes, Christopher W., additional, Rabe, Stephen G., additional, Dooley, Howard J., additional, Prados, John, additional, Krieger, Wolfgang, additional, Russ, Jonathan S., additional, Jones, G. W., additional, Freedman, Lawrence, additional, de Wit, Maarten J., additional, and Sherry, Michael, additional

Published
2000
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144. Connectivity

Author

Derfler, Frank J., Jr., Mallison, Donald, Fowler, Richard, and Henry, Bill

Published
1992

145. Spain comes of age

Author

Fowler, Richard

Subjects
Cosmetics industry -- Market share, Perfumes industry -- Spain, Toiletries industry -- Statistics, Business, Business, international, Pharmaceuticals and cosmetics industries
Published
1991

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