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102. Black holes, gravitational waves and fundamental physics: a roadmap

Author

Leor Barack, Vitor Cardoso, Samaya Nissanke, Thomas P Sotiriou, Abbas Askar, Chris Belczynski, Gianfranco Bertone, Edi Bon, Diego Blas, Richard Brito, Tomasz Bulik, Clare Burrage, Christian T Byrnes, Chiara Caprini, Masha Chernyakova, Piotr Chruściel, Monica Colpi, Valeria Ferrari, Daniele Gaggero, Jonathan Gair, Juan García-Bellido, S F Hassan, Lavinia Heisenberg, Martin Hendry, Ik Siong Heng, Carlos Herdeiro, Tanja Hinderer, Assaf Horesh, Bradley J Kavanagh, Bence Kocsis, Michael Kramer, Alexandre Le Tiec, Chiara Mingarelli, Germano Nardini, Gijs Nelemans, Carlos Palenzuela, Paolo Pani, Albino Perego, Edward K Porter, Elena M Rossi, Patricia Schmidt, Alberto Sesana, Ulrich Sperhake, Antonio Stamerra, Leo C Stein, Nicola Tamanini, Thomas M Tauris, L Arturo Urena-López, Frederic Vincent, Marta Volonteri, Barry Wardell, Norbert Wex, Kent Yagi, Tiziano Abdelsalhin, Miguel Ángel Aloy, Pau Amaro-Seoane, Lorenzo Annulli, Manuel Arca-Sedda, Ibrahima Bah, Enrico Barausse, Elvis Barakovic, Robert Benkel, Charles L Bennett, Laura Bernard, Sebastiano Bernuzzi, Christopher P L Berry, Emanuele Berti, Miguel Bezares, Jose Juan Blanco-Pillado, Jose Luis Blázquez-Salcedo, Matteo Bonetti, Mateja Bošković, Zeljka Bosnjak, Katja Bricman, Bernd Brügmann, Pedro R Capelo, Sante Carloni, Pablo Cerdá-Durán, Christos Charmousis, Sylvain Chaty, Aurora Clerici, Andrew Coates, Marta Colleoni, Lucas G Collodel, Geoffrey Compère, William Cook, Isabel Cordero-Carrión, Miguel Correia, Álvaro de la Cruz-Dombriz, Viktor G Czinner, Kyriakos Destounis, Kostas Dialektopoulos, Daniela Doneva, Massimo Dotti, Amelia Drew, Christopher Eckner, James Edholm, Roberto Emparan, Recai Erdem, Miguel Ferreira, Pedro G Ferreira, Andrew Finch, Jose A Font, Nicola Franchini, Kwinten Fransen, Dmitry Gal’tsov, Apratim Ganguly, Davide Gerosa, Kostas Glampedakis, Andreja Gomboc, Ariel Goobar, Leonardo Gualtieri, Eduardo Guendelman, Francesco Haardt, Troels Harmark, Filip Hejda, Thomas Hertog, Seth Hopper, Sascha Husa, Nada Ihanec, Taishi Ikeda, Amruta Jaodand, Philippe Jetzer, Xisco Jimenez-Forteza, Marc Kamionkowski, David E Kaplan, Stelios Kazantzidis, Masashi Kimura, Shiho Kobayashi, Kostas Kokkotas, Julian Krolik, Jutta Kunz, Claus Lämmerzahl, Paul Lasky, José P S Lemos, Jackson Levi Said, Stefano Liberati, Jorge Lopes, Raimon Luna, Yin-Zhe Ma, Elisa Maggio, Alberto Mangiagli, Marina Martinez Montero, Andrea Maselli, Lucio Mayer, Anupam Mazumdar, Christopher Messenger, Brice Ménard, Masato Minamitsuji, Christopher J Moore, David Mota, Sourabh Nampalliwar, Andrea Nerozzi, David Nichols, Emil Nissimov, Martin Obergaulinger, Niels A Obers, Roberto Oliveri, George Pappas, Vedad Pasic, Hiranya Peiris, Tanja Petrushevska, Denis Pollney, Geraint Pratten, Nemanja Rakic, Istvan Racz, Miren Radia, Fethi M Ramazanoğlu, Antoni Ramos-Buades, Guilherme Raposo, Marek Rogatko, Roxana Rosca-Mead, Dorota Rosinska, Stephan Rosswog, Ester Ruiz-Morales, Mairi Sakellariadou, Nicolás Sanchis-Gual, Om Sharan Salafia, Anuradha Samajdar, Alicia Sintes, Majda Smole, Carlos Sopuerta, Rafael Souza-Lima, Marko Stalevski, Nikolaos Stergioulas, Chris Stevens, Tomas Tamfal, Alejandro Torres-Forné, Sergey Tsygankov, Kıvanç İ Ünlütürk, Rosa Valiante, Maarten van de Meent, José Velhinho, Yosef Verbin, Bert Vercnocke, Daniele Vernieri, Rodrigo Vicente, Vincenzo Vitagliano, Amanda Weltman, Bernard Whiting, Andrew Williamson, Helvi Witek, Aneta Wojnar, Kadri Yakut, Haopeng Yan, Stoycho Yazadjiev, Gabrijela Zaharijas, Miguel Zilhão, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut des Hautes Etudes Scientifiques (IHES), IHES, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut des Hautes Études Scientifiques (IHES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Barack, L., Cardoso, V., Nissanke, S., Sotiriou, T. P., Askar, A., Belczynski, C., Bertone, G., Bon, E., Blas, D., Brito, R., Bulik, T., Burrage, C., Byrnes, C. T., Caprini, C., Chernyakova, M., Chrusciel, P., Colpi, M., Ferrari, V., Gaggero, D., Gair, J., Garcia-Bellido, J., Hassan, S. F., Heisenberg, L., Hendry, M., Heng, I. S., Herdeiro, C., Hinderer, T., Horesh, A., Kavanagh, B. J., Kocsis, B., Kramer, M., Le Tiec, A., Mingarelli, C., Nardini, G., Nelemans, G., Palenzuela, C., Pani, P., Perego, A., Porter, E. K., Rossi, E. M., Schmidt, P., Sesana, A., Sperhake, U., Stamerra, A., Stein, L. C., Tamanini, N., Tauris, T. M., Urena-Lopez, L. A., Vincent, F., Volonteri, M., Wardell, B., Wex, N., Yagi, K., Abdelsalhin, T., Aloy, M. A., Amaro-Seoane, P., Annulli, L., Arca-Sedda, M., Bah, I., Barausse, E., Barakovic, E., Benkel, R., Bennett, C. L., Bernard, L., Bernuzzi, S., Berry, C. P. L., Berti, E., Bezares, M., Blanco-Pillado, J. J., Blazquez-Salcedo, J. L., Bonetti, M., Boskovic, M., Bosnjak, Z., Bricman, K., Brugmann, B., Capelo, P. R., Carloni, S., Cerda-Duran, P., Charmousis, C., Chaty, S., Clerici, A., Coates, A., Colleoni, M., Collodel, L. G., Compere, G., Cook, W., Cordero-Carrion, I., Correia, M., De La Cruz-Dombriz, A., Czinner, V. G., Destounis, K., Dialektopoulos, K., Doneva, D., Dotti, M., Drew, A., Eckner, C., Edholm, J., Emparan, R., Erdem, R., Ferreira, M., Ferreira, P. G., Finch, A., Font, J. A., Franchini, N., Fransen, K., Gal'Tsov, D., Ganguly, A., Gerosa, D., Glampedakis, K., Gomboc, A., Goobar, A., Gualtieri, L., Guendelman, E., Haardt, F., Harmark, T., Hejda, F., Hertog, T., Hopper, S., Husa, S., Ihanec, N., Ikeda, T., Jaodand, A., Jetzer, P., Jimenez-Forteza, X., Kamionkowski, M., Kaplan, D. E., Kazantzidis, S., Kimura, M., Kobayashi, S., Kokkotas, K., Krolik, J., Kunz, J., Lammerzahl, C., Lasky, P., Lemos, J. P. S., Levi Said, J., Liberati, S., Lopes, J., Luna, R., Ma, Y. -Z., Maggio, E., Mangiagli, A., Montero, M. M., Maselli, A., Mayer, L., Mazumdar, A., Messenger, C., Menard, B., Minamitsuji, M., Moore, C. J., Mota, D., Nampalliwar, S., Nerozzi, A., Nichols, D., Nissimov, E., Obergaulinger, M., Obers, N. A., Oliveri, R., Pappas, G., Pasic, V., Peiris, H., Petrushevska, T., Pollney, D., Pratten, G., Rakic, N., Racz, I., Radia, M., Ramazanoglu, F. M., Ramos-Buades, A., Raposo, G., Rogatko, M., Rosca-Mead, R., Rosinska, D., Rosswog, S., Ruiz-Morales, E., Sakellariadou, M., Sanchis-Gual, N., Sharan Salafia, O., Samajdar, A., Sintes, A., Smole, M., Sopuerta, C., Souza-Lima, R., Stalevski, M., Stergioulas, N., Stevens, C., Tamfal, T., Torres-Forne, A., Tsygankov, S., I Unluturk, Ki., Valiante, R., Van De Meent, M., Velhinho, J., Verbin, Y., Vercnocke, B., Vernieri, D., Vicente, R., Vitagliano, V., Weltman, A., Whiting, B., Williamson, A., Witek, H., Wojnar, A., Yakut, K., Yan, H., Yazadjiev, S., Zaharijas, G., Zilhao, M., Gravitation and Astroparticle Physics Amsterdam, GRAPPA (ITFA, IoP, FNWI), IoP (FNWI), High Energy Astrophys. & Astropart. Phys (API, FNWI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Sperhake, Ulrich [0000-0002-3134-7088], Drew, Amelia [0000-0001-8252-602X], Radia, Miren [0000-0001-8861-2025], Apollo - University of Cambridge Repository, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Ege Üniversitesi, Barack, L, Cardoso, V, Nissanke, S, Sotiriou, T, Askar, A, Belczynski, C, Bertone, G, Bon, E, Blas, D, Brito, R, Bulik, T, Burrage, C, Byrnes, C, Caprini, C, Chernyakova, M, Chruściel, P, Colpi, M, Ferrari, V, Gaggero, D, Gair, J, García-Bellido, J, Hassan, S, Heisenberg, L, Hendry, M, Heng, I, Herdeiro, C, Hinderer, T, Horesh, A, Kavanagh, B, Kocsis, B, Kramer, M, Le Tiec, A, Mingarelli, C, Nardini, G, Nelemans, G, Palenzuela, C, Pani, P, Perego, A, Porter, E, Rossi, E, Schmidt, P, Sesana, A, Sperhake, U, Stamerra, A, Stein, L, Tamanini, N, Tauris, T, Urena-López, L, Vincent, F, Volonteri, M, Wardell, B, Wex, N, Yagi, K, Abdelsalhin, T, Aloy, M, Amaro-Seoane, P, Annulli, L, Arca-Sedda, M, Bah, I, Barausse, E, Barakovic, E, Benkel, R, Bennett, C, Bernard, L, Bernuzzi, S, Berry, C, Berti, E, Bezares, M, Blanco-Pillado, J, Blázquez-Salcedo, J, Bonetti, M, Bošković, M, Bosnjak, Z, Bricman, K, Brügmann, B, Capelo, P, Carloni, S, Cerdá-Durán, P, Charmousis, C, Chaty, S, Clerici, A, Coates, A, Colleoni, M, Collodel, L, Compère, G, Cook, W, Cordero-Carrión, I, Correia, M, de la Cruz-Dombriz, Á, Czinner, V, Destounis, K, Dialektopoulos, K, Doneva, D, Dotti, M, Drew, A, Eckner, C, Edholm, J, Emparan, R, Erdem, R, Ferreira, M, Ferreira, P, Finch, A, Font, J, Franchini, N, Fransen, K, Gal’Tsov, D, Ganguly, A, Gerosa, D, Glampedakis, K, Gomboc, A, Goobar, A, Gualtieri, L, Guendelman, E, Haardt, F, Harmark, T, Hejda, F, Hertog, T, Hopper, S, Husa, S, Ihanec, N, Ikeda, T, Jaodand, A, Jetzer, P, Jimenez-Forteza, X, Kamionkowski, M, Kaplan, D, Kazantzidis, S, Kimura, M, Kobayashi, S, Kokkotas, K, Krolik, J, Kunz, J, Lämmerzahl, C, Lasky, P, Lemos, J, Levi Said, J, Liberati, S, Lopes, J, Luna, R, Ma, Y, Maggio, E, Mangiagli, A, Montero, M, Maselli, A, Mayer, L, Mazumdar, A, Messenger, C, Ménard, B, Minamitsuji, M, Moore, C, Mota, D, Nampalliwar, S, Nerozzi, A, Nichols, D, Nissimov, E, Obergaulinger, M, Obers, N, Oliveri, R, Pappas, G, Pasic, V, Peiris, H, Petrushevska, T, Pollney, D, Pratten, G, Rakic, N, Racz, I, Radia, M, Ramazanoğlu, F, Ramos-Buades, A, Raposo, G, Rogatko, M, Rosca-Mead, R, Rosinska, D, Rosswog, S, Ruiz-Morales, E, Sakellariadou, M, Sanchis-Gual, N, Sharan Salafia, O, Samajdar, A, Sintes, A, Smole, M, Sopuerta, C, Souza-Lima, R, Stalevski, M, Stergioulas, N, Stevens, C, Tamfal, T, Torres-Forné, A, Tsygankov, S, İ Ünlütürk, K, Valiante, R, van de Meent, M, Velhinho, J, Verbin, Y, Vercnocke, B, Vernieri, D, Vicente, R, Vitagliano, V, Weltman, A, Whiting, B, Williamson, A, Witek, H, Wojnar, A, Yakut, K, Yan, H, Yazadjiev, S, Zaharijas, G, and Zilhão, M

Subjects
High Energy Physics - Theory, cosmological model, Physics and Astronomy (miscellaneous), Event horizon, Astronomy, 01 natural sciences, General Relativity and Quantum Cosmology, Cosmology, Physics, Particles & Fields, Gravitation, High Energy Physics::Theory, black hole: formation, Vacuum energy, black hole, general relativity, NEUTRON-STAR, GENERAL-RELATIVITY, dark energy, STAR CLUSTER SIMULATIONS, gravitational wave, QC, QB, media_common, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, Quantum Science & Technology, [PHYS.HTHE]Physics [physics]/High Energy Physics - Theory [hep-th], hep-th, source modelling, BRANS-DICKE THEORY, fundamental physic, gravitational waves, QUASI-NORMAL MODES, Physical Sciences, birth and evolution of black holes, black holes, fundamental physics, gravitational-wave astronomy, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], HIGH-REDSHIFT FORMATION, Astrophysics - High Energy Astrophysical Phenomena, SCALAR-TENSOR THEORIES, General relativity, media_common.quotation_subject, gr-qc, Physics, Multidisciplinary, birth and evolution of black hole, FOS: Physical sciences, ST/R00045X/1, General Relativity and Quantum Cosmology (gr-qc), Astronomy & Astrophysics, gravitational radiation: direct detection, horizon, vacuum state: energy, Theoretical physics, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, inflation, 010306 general physics, STFC, Science & Technology, 010308 nuclear & particles physics, Gravitational wave, Physique, gravitational radiation, RCUK, ST/P000703/1, R-PROCESS NUCLEOSYNTHESIS, Astronomie, singularity, Universe, High Energy Physics - Theory (hep-th), gravitation, black hole: model, TIMING ARRAY LIMITS, Dark energy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], X-RAY BINARIES
Abstract

The grand challenges of contemporary fundamental physics-dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem-all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress. This write-up is an initiative taken within the framework of the European Action on 'Black holes, Gravitational waves and Fundamental Physics'., SCOPUS: re.j, info:eu-repo/semantics/published

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103. Black holes, gravitational waves and fundamental physics: a roadmap

Author

Ramazanoğlu, Fethi Mübin (ORCID 0000-0003-3075-1457 & YÖK ID 254225), Ünlütürk, Kıvanç İbrahim, Barack, Leor, Cardoso, Vitor, Nissanke, Samaya, Sotiriou, Thomas P., Askar, Abbas, Belczynski, Chris, Bertone, Gianfranco, Bon, Edi, Blas, Diego, Brito, Richard, Bulik, Tomasz, Burrage, Clare, Byrnes, Christian T., Caprini, Chiara, Chernyakova, Masha, Chrusciel, Piotr, Colpi, Monica, Ferrari, Valeria, Gaggero, Daniele, Gair, Jonathan, Garcia-Bellido, Juan, Hassan, S. F., Heisenberg, Lavinia, Hendry, Martin, Heng, Ik Siong, Herdeiro, Carlos, Hinderer, Tanja, Horesh, Assaf, Kavanagh, Bradley J., Kocsis, Bence, Kramer, Michael, Le Tiec, Alexandre, Mingarelli, Chiara, Nardini, Germano, Nelemans, Gijs, Palenzuela, Carlos, Pani, Paolo, Perego, Albino, Porter, Edward K., Rossi, Elena M., Schmidt, Patricia, Sesana, Alberto, Sperhake, Ulrich, Stamerra, Antonio, Stein, Leo C., Tamanini, Nicola, Tauris, Thomas M., Arturo Urena-Lopez, L., Vincent, Frederic, Volonteri, Marta, Wardell, Barry, Wex, Norbert, Yagi, Kent, Abdelsalhin, Tiziano, Angel Aloy, Miguel, Amaro-Seoane, Pau, Annulli, Lorenzo, Arca-Sedda, Manuel, Bah, Ibrahima, Barausse, Enrico, Barakovic, Elvis, Benkel, Robert, Bennett, Charles L., Bernard, Laura, Bernuzzi, Sebastiano, Berry, Christopher P. L., Berti, Emanuele, Bezares, Miguel, Juan Blanco-Pillado, Jose, Blazquez-Salcedo, Jose Luis, Bonetti, Matteo, Boskovic, Mateja, Bosnjak, Zeljka, Bricman, Katja, Bruegmann, Bernd, Capelo, Pedro R., Carloni, Sante, Cerda-Duran, Pablo, Charmousis, Christos, Chaty, Sylvain, Clerici, Aurora, Coates, Andrew, Colleoni, Marta, Collodel, Lucas G., Compere, Geoffrey, Cook, William, Cordero-Carrion, Isabel, Correia, Miguel, de la Cruz-Dombriz, Alvaro, Czinner, Viktor G., Destounis, Kyriakos, Dialektopoulos, Kostas, Doneva, Daniela, Dotti, Massimo, Drew, Amelia, Eckner, Christopher, Edholm, James, Emparan, Roberto, Erdem, Recai, Ferreira, Miguel, Ferreira, Pedro G., Finch, Andrew, Font, Jose A., Franchini, Nicola, Fransen, Kwinten, Gal'tsov, Dmitry, Ganguly, Apratim, Gerosa, Davide, Glampedakis, Kostas, Gomboc, Andreja, Goobar, Ariel, Gualtieri, Leonardo, Guendelman, Eduardo, Haardt, Francesco, Harmark, Troels, Hejda, Filip, Hertog, Thomas, Hopper, Seth, Husa, Sascha, Ihanec, Nada, Ikeda, Taishi, Jaodand, Amruta, Jetzer, Philippe, Jimenez-Forteza, Xisco, Kamionkowski, Marc, Kaplan, David E., Kazantzidis, Stelios, Kimura, Masashi, Kobayashi, Shiho, Kokkotas, Kostas, Krolik, Julian, Kunz, Jutta, Laemmerzahl, Claus, Lasky, Paul, Lemos, Jose P. S., Said, Jackson Levi, Liberati, Stefano, Lopes, Jorge, Luna, Raimon, Ma, Yin-Zhe, Maggio, Elisa, Mangiagli, Alberto, Montero, Marina Martinez, Maselli, Andrea, Mayer, Lucio, Mazumdar, Anupam, Messenger, Christopher, Menard, Brice, Minamitsuji, Masato, Moore, Christopher J., Mota, David, Nampalliwar, Sourabh, Nerozzi, Andrea, Nichols, David, Nissimov, Emil, Obergaulinger, Martin, Obers, Niels A., Oliveri, Roberto, Pappas, George, Pasic, Vedad, Peiris, Hiranya, Petrushevska, Tanja, Pollney, Denis, Pratten, Geraint, Rakic, Nemanja, Racz, Istvan, Radia, Miren, Ramazanoglu, Fethi M., Ramos-Buades, Antoni, Raposo, Guilherme, Rogatko, Marek, Rosca-Mead, Roxana, Rosinska, Dorota, Rosswog, Stephan, Ruiz-Morales, Ester, Sakellariadou, Mairi, Sanchis-Gual, Nicolas, Salafia, Om Sharan, Samajdar, Anuradha, Sintes, Alicia, Smole, Majda, Sopuerta, Carlos, Souza-Lima, Rafael, Stalevski, Marko, Stergioulas, Nikolaos, Stevens, Chris, Tamfal, Tomas, Torres-Forne, Alejandro, Tsygankov, Sergey, Valiante, Rosa, van de Meent, Maarten, Velhinho, Jose, Verbin, Yosef, Vercnocke, Bert, Vernieri, Daniele, Vicente, Rodrigo, Vitagliano, Vincenzo, Weltman, Amanda, Whiting, Bernard, Williamson, Andrew, Witek, Helvi, Wojnar, Aneta, Yakut, Kadri, Yan, Haopeng, Yazadjiev, Stoycho, Zaharijas, Gabrijela, Zilhao, Miguel, College of Sciences, Graduate School of Sciences and Engineering, and Department of Physics

Subjects
General Relativity and Quantum Cosmology, Astronomy and astrophysics, Quantum science and technology, Gravitational waves, Gravitational-wave astronomy, Source modelling, Black holes, Fundamental physics, Birth and evolution of black holes, Physics, multidisciplinary, Physics, particles and fields
Abstract

The grand challenges of contemporary fundamental physics dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions.The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature.The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress., European Union (EU); European Cooperation in Science and Technology (COST); Polish National Science Center (NCN); Carl Tryggers Foundation; Science & Technology Facilities Council (STFC); European Union's H2020 ERC Consolidator Grant 'Matter and strong-field gravity: New frontiers in Einstein's theory'; European Research Council (ERC); Horizon 2020; Science & Technology Facilities Council (STFC; Ministry of Education and Science of the Republic of Serbia; Foundation for Polish Science; Austrian Science Fund (FWF); Polish National Center of Science (NCN); European Research Council (ERC); Hungarian National Research, Development, and Innovation Office; Swiss National Science Foundation (SNSF); European Union's H2020 ERC; H2020-MSCA-RISE-2015 Grant; National Science Foundation (NSF); PRACE; Simons Foundation; Ministry of Economy, Industry and Competitiveness of Spain; Slovenian Research Agency - Slovenia; EU H2020 under ERC; Spanish MINECO; Generalitat Valenciana; NASA by the Chandra X-ray Center; National Aeronautics & Space Administration (NASA); Scientific and Technological Research Council of Turkey (TÜBİTAK); H2020-MSCA-RISE-2017 Grant; Scientific and Technological Research Council of Turkey (TÜBİTAK); National Science Centre of Poland - European Union; Deutscher Akademischer Austausch Dienst (DAAD); GWAVES of ARIS-GRNET(Athens); Royal Society of London; Research Grant; Scientific and Technological Research Council of Turkey (TÜBİTAK)

Published
2019

104. Surveillance of Enterobacteriaceae from Diabetic Foot Infections in a Tunisian Hospital: Detection of E. coli- ST131- bla CTX-M-15 and K. pneumoniae -ST1- bla NDM-1 Strains.

Author

Arfaoui A, Martínez-Álvarez S, Abdullahi IN, Fethi M, Sayem N, Melki SBK, Ouzari HI, Torres C, and Klibi N

Subjects
Humans, Tunisia epidemiology, Hospitals, Bacterial Proteins genetics, Phylogeny, Diabetic Foot microbiology, Anti-Bacterial Agents pharmacology, beta-Lactamases genetics, Microbial Sensitivity Tests, Escherichia coli genetics, Escherichia coli drug effects, Escherichia coli isolation & purification, Drug Resistance, Multiple, Bacterial genetics, Klebsiella pneumoniae genetics, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae isolation & purification
Abstract

The study determined the prevalence, antimicrobial resistant (AMR) determinants, and genetic characteristics of Escherichia coli and Klebsiella pneumoniae isolates from patients with diabetic foot infection (DFI) in a Tunisian hospital. A total of 26 Escherichia spp. and Klebsiella spp. isolates were recovered and identified by MALDI-TOF-MS. Antimicrobial susceptibility testing, the detection of AMR determinants and Shiga-like toxin genes, phylogenetic grouping, and molecular typing were performed. Twelve E. coli , 10 K. pneumoniae , 3 K. oxytoca , and 1 E. hermanii were isolated. A multidrug-resistant phenotype was detected in 65.4% of the isolates. About 30.8% of isolates were extended-spectrum β-lactamase (ESBL) producers and mainly carried bla CTX -M-15 and bla CTX -M-14 genes. One bla NDM -1 -producing K. pneumoniae- ST1 strain was identified. Class 1 integrons were detected in 11 isolates and 5 gene cassette arrangements were noted: dfrA1+aadA1 ( n = 1), dfrA12+aadA2 ( n = 3), and dfrA17+aadA5 ( n = 1). Other non-β-lactam resistance genes detected were as follows (number of isolates): aac(3')-II (3), aac(6')-Ib-cr (8), qnrB (2), qnrS (4), cmlA (2), floR (4), sul1 (11), sul2 (11), and sul3 (2). The phylogroup B1 was the most frequent (41.7%) among E. coli , and two ESBL-producing isolates corresponded to the ST131-B2 lineage. The ESBL- and carbapenemase-producing Enterobacteriaceae in DFIs are described for the first time in Tunisia.

Published
2024
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105. Molecular characterization of Pseudomonas aeruginosa from diabetic foot infections in Tunisia.

Author

Arfaoui A, Rojo-Bezares B, Fethi M, López M, Toledano P, Sayem N, Ben Khelifa Melki S, Ouzari HI, Klibi N, and Sáenz Y

Subjects
Humans, Tunisia epidemiology, Male, Female, Middle Aged, Aged, Prospective Studies, Biofilms growth & development, Virulence genetics, Multilocus Sequence Typing, Adult, Virulence Factors genetics, Drug Resistance, Multiple, Bacterial genetics, Aged, 80 and over, Prevalence, Pseudomonas aeruginosa genetics, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa isolation & purification, Pseudomonas aeruginosa classification, Pseudomonas aeruginosa pathogenicity, Diabetic Foot microbiology, Pseudomonas Infections microbiology, Pseudomonas Infections epidemiology, Anti-Bacterial Agents pharmacology, Microbial Sensitivity Tests
Abstract

Background. Pseudomonas aeruginosa is an invasive organism that frequently causes severe tissue damage in diabetic foot ulcers. Gap statement. The characterisation of P. aeruginosa strains isolated from diabetic foot infections has not been carried out in Tunisia. Purpose. The aim was to determine the prevalence of P. aeruginosa isolated from patients with diabetic foot infections (DFIs) in Tunisia and to characterize their resistance, virulence and molecular typing. Methods. Patients with DFIs admitted to the diabetes department of the International Hospital Centre of Tunisia, from September 2019 to April 2021, were included in this prospective study. P. aeruginosa were obtained from the wound swabs, aspiration and soft tissue biopsies during routine clinical care and were confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Antimicrobial susceptibility testing, serotyping, integron and OprD characterization, virulence, biofilm production, pigment quantification, elastase activity and molecular typing were analysed in all recovered P. aeruginosa isolates by phenotypic tests, specific PCRs, sequencing, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing. Results. Sixteen P. aeruginosa isolates (16.3 %) were recovered from 98 samples of 78 diabetic patients and were classified into 6 serotypes (O:11 the most frequent), 11 different PFGE patterns and 10 sequence types (three of them new ones). The high-risk clone ST235 was found in two isolates. The highest resistance percentages were observed to netilmicin (69 %) and cefepime (43.8 %). Four multidrug-resistant (MDR) isolates (25 %) were detected, three of them being carbapenem-resistant. The ST235-MDR strain harboured the In51 class 1 integron ( intI1 +aadA6+orfD+qacED1-sul1 ). According to the detection of 14 genes involved in virulence or quorum sensing, 5 virulotypes were observed, including 5 exoU -positive, 9 exoS -positive and 2 exoU/exoS -positive strains. The lasR gene was truncated by IS Ppu21 insertion sequence in one isolate, and a deletion of 64 bp in the rhlR gene was detected in the ST235-MDR strain. Low biofilm, pyoverdine and elastase production were detected in all P. aeruginosa ; however, the lasR -truncated strain showed a chronic infection phenotype characterized by loss of serotype-specific antigenicity, high production of phenazines and high biofilm formation. Conclusions. Our study demonstrated for the first time the prevalence and the molecular characterization of P. aeruginosa strains from DFIs in Tunisia, showing a high genetic diversity, moderate antimicrobial resistance, but a high number of virulence-related traits, highlighting their pathological importance.

Published
2024
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106. TNF-α -308A/G SNP association with kidney allograft rejection in Algerian population: A retrospective case-control study.

Author

Asmaa C, Rachida R, Asma D, Louiza K, Souad C, Leila B, Ali B, Messaoud S, Dalila K, Fethi M, Nawel S, Malika A, Bachira M, Nabila A, Chafia TB, and Habiba AAB

Subjects
Humans, Retrospective Studies, Case-Control Studies, Kidney, HLA Antigens genetics, Genotype, Allografts, Tumor Necrosis Factor-alpha genetics, Polymorphism, Single Nucleotide
Abstract

No consensus has been reached regarding the association beween the -308A/G single nucleotide polymorphism (SNP) in the tumor necrosis factor-α gene (TNFA) and kidney allograft rejection (KAR). Our retrospective case-control study aimed to assess the association of the SNP with KAR in Algerian patients who underwent kidney transplantation. The study enrolled 313 Algerian patients: 58 kidney-transplant recipients without rejection events (PWoR); 58 kidney-transplant recipients with at least one rejection event, with or without graft loss (PWR); and 197 healthy individuals (HI). The TNFA -308A/G SNP was genotyped using a real-time polymerase chain reaction. The results demonstrated that, the frequencies of TNFA -308A allele and AA genotype were higher in the PWR than in the HI groups (p = 0.001, OR = 2.26, CI = 1.33-3.77 and p = 0.0004, OR = 5.53, CI-1.89-16.6, respectively). Furthermore, the frequencies were higher among the PWR than among the PWoR groups (p = 0.001, OR = 3.29, CI = 1.56-7.21 and p = 0.0006, OR = 28.26, CI = 1.62-493.2, respectively), particularly among PWR patients with de novo anti-human leukocyte antigens (HLA) antibodies (PG-a-HLA-Ab). However, the frequency of TNFA -308G allele was lower in the PWR group than in the PWoR group (p = 0.001, OR = 0.3, CI = 0.1-0.64) and the HI group (p = 0.001, OR = 0.44, CI = 0.27-0.44). Our results suggest an association of the TNFA -308A/G alleles with KAR in Algerian patients who underwent kidney transplantation. Carriers of TNFA -308A allele who have PG-a-HLA-Ab might have a higher risk, whereas TNFA -308G allele carriers could have a lower risk of KAR. Thus, therapeutic strategies can be adapted to minimize KAR risk in patients who have a genetic proclivity for increased pro-inflammatory TNF-α activity., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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107. High Prevalence of GES-5 Variant and Co-Expression of VIM-2 and GES-45 among Clinical Pseudomonas aeruginosa Strains in Tunisia.

Author

Fethi M, Rojo-Bezares B, Arfaoui A, Dziri R, Chichón G, Barguellil F, López M, El Asli MS, Toledano P, Ouzari HI, Sáenz Y, and Klibi N

Abstract

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are a global health concern. The antimicrobial resistance, virulence, and molecular typing of 57 CRPA isolated from 43 patients who attended a specific Tunisian hospital from September 2018 to July 2019 were analyzed. All but one were multidrug-resistant CRPA, and 77% were difficult-to-treat-resistant (DTR) isolates. The bla VIM-2 gene was detected in four strains (6.9%), and among the 36 bla GES -positive CRPA (62%), the bla GES-5 gene was the predominant variant (86%). Three strains co-harbored the bla VIM-2 and bla GES-45 genes, and seven CRPA carried the bla SHV-2a gene (14%). OprD alterations, including truncations by insertion sequences, were observed in 18 strains. Regarding the 46 class 1 integron-positive CRPA (81%), the bla GES-5 gene was located in integron In717, while the bla GES-29 and bla GES-45 genes were found in two new integrons (In2122 and In4879), and the bla VIM-2 gene was found in In1183 and the new integron In2142. Twenty-four PFGE patterns and thirteen sequence types (three new ones) were identified. The predominant serotype O:11 and exoU (81%) were mostly associated with ST235 and the new ST3385 clones. The seven bla SHV-2a- CRPA from different patients belonged to ST3385 and the same PFGE pattern. The bla GES-5 - and bla VIM-2 + bla GES-45 -positive CRPA recovered mostly from ICU patients belonged to the high-risk clone ST235. Our results highlight the alarming prevalence of bla GES-5- and ST235-CRPA, the co-existence of bla GES-45 and bla VIM-2 , and their location within integrons favoring their dissemination.

Published
2023
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108. Whole Genome Sequencing of a Citrobacter freundii Strain Isolated from the Hospital Environment: An Extremely Multiresistant NDM-1 and VIM-48 Coproducing Isolate.

Author

Dziri R, Kuşkucu MA, Arfaoui A, Fethi M, Ifaoui S, Bellaaj R, Ouzari I, Saltoğlu N, and Klibi N

Subjects
Citrobacter freundii genetics, Cross Infection microbiology, Genes, Bacterial, Humans, Microbial Sensitivity Tests, Multilocus Sequence Typing, Plasmids, RNA, Long Noncoding genetics, Whole Genome Sequencing, beta-Lactamases, Anti-Bacterial Agents pharmacology, Drug Resistance, Multiple, Bacterial genetics
Abstract

Citrobacter freundii has acquired resistance to several antimicrobial drugs, including last-resort antibiotics affecting, therefore, clinical efficacy and causing high rates of mortality. In this study, we investigate the whole genome sequence of a carbapenem-resistant C. freundii strain isolated from the hospital environment in Tunisia. A total of 210 samples were taken using sterile swabs, from inanimate surfaces, medical devices, and care staff, during the period extended between March and April 2019. After the microbiological analysis of samples and antimicrobial susceptibility testing, only one strain identified as C. freundii showing resistance to carbapenems was selected for the whole genome sequencing. The genome analysis revealed a high-level resistance to most antibiotics. Interestingly, we have noted the coexistence of bla NDM-1 and bla VIM-48 metallo-β-lactamase (MBL) encoding genes conferring resistance to carbapenems. Other β-lactamases encoding genes have also been detected, including bla TEM-1 , bla CMY-48 , and bla OXA-1 . Moreover, genes conferring resistance to aminoglycoside [ aac (3)-IId, ant (3″)-Ia, aad A, aac (6')-Ib], macrolide [ mph (A)], sulfonamide ( sul 1), trimethoprim ( dfr A1), tetracycline [ tet (D)], chloramphenicol [ cat (B3)], rifamycin ( arr -3), and quinolone ( qnr B) have been revealed. The multi-locus sequence typing analysis showed that this isolate could not be assigned to an existing sequence type (ST), but it is almost identical to ST22. The plasmid investigation revealed the presence of five plasmids belonging to diverse incompatibility groups (IncFII, IncHI1A, IncHI1B, IncN, and IncX3). To the best of our knowledge, our findings report the first detection of NDM-1 and VIM-48 coproducing C. freundii in Tunisia and the second detection in the world of the bla VIM-48 .

Published
2022
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109. Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant Pseudomonas aeruginosa Tunisian Clinical Isolates.

Author

Troudi A, Fethi M, Selim El Asli M, Bolla JM, Klibi N, and Brunel JM

Abstract

The growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are needed. Recently, we demonstrated that combination of a tetracycline antibiotic with various polyaminoisoprenyl adjuvants can sustain the life span and enhance the activity of these drugs against Pseudomonas aeruginosa reference strain (PA01). In the context of our continuing studies, the effective approach of antibiotic-adjuvant was investigated against a large panel of P. aeruginosa Tunisian clinical strains collected from the Military Hospital of Tunis. In this paper, we demonstrated that the combination of a farnesyl spermine compound 3 used at concentrations ranging from 2.5 to 10 µM, in the presence of doxycycline or minocycline leads to a significant decrease of P. aeruginosa antibiotic resistance.

Published
2020
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110. Treatment of pre-eruptive intracoronal resorption: A scoping review.

Author

Chouchene F, Hammami W, Ghedira A, Masmoudi F, Baaziz A, Fethi M, and Ghedira H

Subjects
Child, Dental Pulp, Humans, Tooth Eruption, Dental Caries, Tooth Resorption, Tooth, Unerupted
Abstract

Aim: Pre-eruptive intra-coronal resorption (PEIR) is a rare condition that can affect children's dentition. Showing the same aspect of dental caries, these lesions are diagnosed in non-erupted teeth. The aetiology is not yet defined and no consensus on their treatment is available. Thus, the aim of the present scoping review of the literature was to try to establish a protocol for treatment and management of PEIR defects., Methods: The search was performed on Medline via PubMed, Science Direct and EBSCOhost' databases using the appropriate Medical Subject Headings (MESH) terms. Studies that described the PEIR were considered eligible and the data from the selected papers were extracted and analysed independently by two authors., Results: Out of 172 articles identified in initial research, 15 articles were selected for reviewing. Interventions varied from preventive treatment to extraction, depending on the lesion severity and its proximity to the pulp., Conclusion: Non-operative procedures, conservative approaches and extractions were recommended for the management of PEIR, depending on the extent of the lesions. Overall, further researches should be conducted to explore the effectiveness of the approaches of PEIR management.

Published
2020
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111. [Squamous cell carcinomas of the scrotum: about 7 cases with review of the literature].

Author

Halfya A, Elmortaji K, Redouane R, Fethi M, Rafik A, Mohamed E, and Abdessamad C

Subjects
Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bleomycin administration & dosage, Cisplatin administration & dosage, Early Detection of Cancer, Genital Neoplasms, Male diagnosis, Genital Neoplasms, Male etiology, Genital Neoplasms, Male therapy, Humans, Incidence, Lymph Node Excision, Lymphatic Metastasis, Male, Methotrexate administration & dosage, Middle Aged, Neoadjuvant Therapy, Radiotherapy, Adjuvant, Plastic Surgery Procedures, Skin Transplantation, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell etiology, Carcinoma, Squamous Cell therapy, Genital Neoplasms, Male epidemiology, Scrotum pathology
Published
2015
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112. [Primitif colonic lymphoma: a rare digestive tumor].

Author

Daldoul S, El Jeri K, Talbi G, Fethi M, Najjar T, and Zaouche A

Subjects
Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Colonic Neoplasms diagnosis, Lymphoma, B-Cell, Marginal Zone diagnosis
Published
2014

113. Restriction mapping of βS locus among Tunisian sickle-cell patients.

Author

Imen M, Ikbel BM, Leila C, Fethi M, Amine Z, Mohamed B, and Salem A

Subjects
Adolescent, Child, Child, Preschool, DNA Mutational Analysis, Emigration and Immigration, Female, Fetal Hemoglobin genetics, Humans, Infant, Male, Multigene Family, Polymorphism, Restriction Fragment Length, Restriction Mapping, Tunisia, Anemia, Sickle Cell genetics, Haplotypes genetics, beta-Globins genetics
Abstract

Objectives: The polymorphism of the β-globin gene haplotypes and frameworks is useful in the determination of the unicentric and multicentric origin of a mutational event. In our study, the haplotypes linked to the Tunisian β(S) mutation are determined to improve our knowledge of the chromosomal background of the β-globin gene in sickle-cell anemia in Tunisia., Methods: The authors have investigated 242 unrelated individuals. Haplotype analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism-based methods. Seven polymorphic sites in the β-globin gene cluster were examined. The correlation of these various haplotypes with Hb F expression was studied., Results: The Benin haplotype (Ben) was largely predominant (60.54%) followed by the Atypical haplotype A (8.43%) and Bantu (Ban) (2.71%) haplotypes. A total of 94 chromosomes had atypical haplotypes, 78 (23.49%) had A1 [-----++], 11 (3.31%) had A2 [-------], and five (1.5%) had B1 [--+--++]. The Benin haplotype is associated with a fairly low HbF levels., Conclusion: The very high frequency of the Benin haplotype in our study suggests that the β(S) mutation present in Tunisia may have originated from the Benin region and was brought to Tunisia along the slave trade routes. However, another atypical haplotype observed a new emergence in our population and could be considered as specific to Tunisian chromosome β(S)., (Copyright © 2011 Wiley-Liss, Inc.)

Published
2011
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