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101. Exosomal miR-10527-5p Inhibits Migration, Invasion, Lymphangiogenesis and Lymphatic Metastasis by Affecting Wnt/β-Catenin Signaling via Rab10 in Esophageal Squamous Cell Carcinoma

Author: Xiao Z, Feng X, Zhou Y, Li P, Luo J, Zhang W, Zhou J, Zhao J, Wang D, Wang Y, Tian Z, and Zhao X
Subjects: esophageal squamous cell carcinoma, exosomes, mir-10527-5p, biomarker, lymphangiogenesis, Medicine (General), R5-920
Abstract: Zhaohua Xiao,1 Xumei Feng,2 Yongjia Zhou,1 Peiwei Li,3 Junwen Luo,1 Wenhao Zhang,1 Jie Zhou,1 Jiangfeng Zhao,1 Dong Wang,4 Yongjie Wang,5 Zhongxian Tian,1,6 Xiaogang Zhao1,6 1Department of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, 250033, People’s Republic of China; 2Health Management Center, The Second Hospital of Shandong University, Jinan, People’s Republic of China; 3Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan, People’s Republic of China; 4Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China; 5Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 6Key Laboratory of Chest Cancer, Shandong University, The Second Hospital of Shandong University, Jinan, People’s Republic of ChinaCorrespondence: Zhongxian Tian; Xiaogang Zhao, Department of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, 250033, People’s Republic of China, Tel +86-17660082365 ; +86-053185875009, Email tianzhongxian@email.sdu.edu.cn; zhaoxiaogang@sdu.edu.cnBackground: Cancer cell-derived exosomal microRNAs (miRNAs) play critical role in orchestrating intercellular communication between tumor cells and tumor microenvironmental factors, including lymphatic endothelial cells (LECs). Nevertheless, the functions and underlying mechanisms of exosomal miRNAs in lymphatic metastasis and lymphangiogenesis in esophageal squamous cell carcinoma (ESCC) remain unclear.Methods: Small RNA sequencing, Gene Expression Omnibus (GEO) analysis and qRT‒PCR were performed to identify the candidate exosomal miRNAs involved in ESCC metastasis. Receiver operating characteristic curve analysis was conducted to evaluate the diagnostic potential of exosomal miR-10527-5p in predicting lymph node metastasis (LNM) status. An in vitro coculture system was used to investigate the effects of exosomal miR-10527-5p on ESCC cells and human LECs (HLECs), followed by a popliteal LNM assay in vivo. The relationship between miR-10527-5p and Rab10 was identified by dual-luciferase reporter, fluorescence in situ hybridization and qRT‒PCR assays. Then, a series of rescue assays were performed to further investigate whether Rab10 is involved in exosomal miR-10527-5p mediated ESCC metastasis.Results: MiR-10527-5p was found to be notably reduced in both the plasma exosomes and tumor tissues of ESCC patients with LNM, and plasma exosomal miR-10527-5p had a high sensitivity and specificity for discrimination of LNM status. Moreover, exosome-shuttled miR-10527-5p suppressed the migration, invasion and epithelial-to-mesenchymal transition (EMT) of ESCC cells as well as the migration and tube formation of HLECs via Wnt/β-catenin signaling in vitro and in vivo. Further investigation revealed that Rab10 was a direct target of miR-10527-5p, and re-expression of Rab10 neutralized the inhibitory effects of exosomal miR-10527-5p.Conclusion: Our study demonstrated that exosomal miR-10527-5p had a strong capability to predict preoperative LNM status and anti-lymphangiogenic effect. Exosomal miR-10527-5p inhibited lymphangiogenesis and lymphatic metastasis of ESCC in a vascular endothelial growth factor-C (VEGF-C)-independent manner, showing potential as a therapeutic target for ESCC patients.Keywords: esophageal squamous cell carcinoma, exosomes, miR-10527-5p, biomarker, lymphangiogenesis
Published: 2023

102. The storage and preservation of meat: II—Nonthermal technologies

Author: Ahn, D.U., primary, Mendonca, A., additional, and Feng, X., additional
Published: 2023
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103. Contributors

Author: Ahn, D.U., primary, Basu, Lopa, additional, Calvo, Luis, additional, Champomier-Vergès, Marie-Christine, additional, Dasenaki, Marilena E., additional, Ertbjerg, Per, additional, Faustman, Cameron, additional, Feng, X., additional, Flores, Mónica, additional, Fontanesi, Luca, additional, Gehring, Kerri B., additional, Gerrard, David E., additional, Holman, Benjamin W.B., additional, Hopkins, David L., additional, Kang, Dacheng, additional, Kerry, Joe P., additional, Kritikou, Anastasia S., additional, Lianou, Alexandra, additional, López-Bote, Clemente, additional, Matarneh, Sulaiman K., additional, McGee, Mark, additional, Mendonca, A., additional, Miller, Rhonda K., additional, Moloney, Aidan P., additional, Nychas, George-John E., additional, Ockerman, Herbert W., additional, Panagou, Efstathios Z., additional, Ponnampalam, Eric N., additional, Purslow, Peter P., additional, Ramanathan, Ranjith, additional, Savell, Jeffrey W., additional, Scheffler, Tracy L., additional, Suman, Surendranath P., additional, Thomaidis, Nikolaos S., additional, Toldrá, Fidel, additional, Tyuftin, Andrey A., additional, Warner, Robyn Dorothy, additional, Wood, Jeffrey D., additional, Xiong, Youling L., additional, Zagorec, Monique, additional, and Zhang, Wangang, additional
Published: 2023
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104. A lithium-sulfur battery with a solution-mediated pathway operating under lean electrolyte conditions

Author: Wang, H, Shao, Y, Pan, H, Feng, X, Chen, Y, Liu, YS, Walter, ED, Engelhard, MH, Han, KS, Deng, T, Ren, G, Lu, D, Lu, X, Xu, W, Wang, C, Feng, J, Mueller, KT, Guo, J, Zavadil, KR, and Zhang, JG
Subjects: Macromolecular and Materials Chemistry, Materials Engineering, Nanotechnology
Abstract: Lithium-sulfur (Li–S) battery is one of the most promising candidates for the next generation energy storage systems. However, several barriers, including polysulfide shuttle effect, the slow solid-solid surface reaction pathway in the lower discharge plateau, and corrosion of Li anode still limit its practical applications, especially under the lean electrolyte condition required for high energy density. Here, we propose a solution-mediated sulfur reduction pathway to improve the capacity and reversibility of the sulfur cathode. With this method, a high coulombic efficiency (99%) and stable cycle life over 100 cycles were achieved under application-relevant conditions (S loading: 6.2 mg cm−2; electrolyte to sulfur ratio: 3 mLE gs−1; sulfur weight ratio: 72 wt%). This result is enabled by a specially designed Li2S4-rich electrolyte, in which Li2S is formed through a chemical disproportionation reaction instead of electrochemical routes. A single diglyme solvent was used to obtain electrolytes with the optimum range of Li2S4 concentration. Operando X-ray absorption spectroscopy confirms the solution pathway in a practical Li–S cell. This solution pathway not only introduces a new electrolyte regime for practical Li–S batteries, but also provides a new perspective for bypassing the inefficient surface pathway for other electrochemical processes.
Published: 2020

105. Reconstruction of Cherenkov image by multiple telescopes of LHAASO-WFCTA

Author: Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Zhe, Cao, Zhen, Chang, J., Chang, J. F., Chen, E. S., Chen, Liang, Chen, Liang, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, H. L., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., D’Ettorre Piazzoli, B., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Duan, K. K., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, W. H., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Levochkin, K., Li, B. B., Li, Cheng, Li, Cong, Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Long, W. J., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Min, Z., Mitthumsiri, W., Nan, Y. C., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. Y., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R., Wang, R. N., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yan, J. Z., Yang, C. W., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, Lu, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Y. L., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.
Published: 2022
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106. Electronic structure of the parent compound of superconducting infinite-layer nickelates

Author: Hepting, M., Li, D., Jia, C. J., Lu, H., Paris, E., Tseng, Y., Feng, X., Osada, M., Been, E., Hikita, Y., Chuang, Y. -D., Hussain, Z., Zhou, K. J., Nag, A., Garcia-Fernandez, M., Rossi, M., Huang, H. Y., Huang, D. J., Shen, Z. X., Schmitt, T., Hwang, H. Y., Moritz, B., Zaanen, J., Devereaux, T. P., and Lee, W. S.
Subjects: Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract: The search for oxide materials with physical properties similar to the cuprate high Tc superconductors, but based on alternative transition metals such as nickel, has grown and evolved over time. The recent discovery of superconductivity in doped infinite-layer nickelates RNiO2 (R = rare-earth element) further strengthens these efforts.With a crystal structure similar to the infinite-layer cuprates - transition metal oxide layers separated by a rare-earth spacer layer - formal valence counting suggests that these materials have monovalent Ni1+ cations with the same 3d electron count as Cu2+ in the cuprates. Here, we use x-ray spectroscopy in concert with density functional theory to show that the electronic structure of RNiO2 (R = La, Nd), while similar to the cuprates, includes significant distinctions. Unlike cuprates with insulating spacer layers between the CuO2 planes, the rare-earth spacer layer in the infinite-layer nickelate supports a weakly-interacting three-dimensional 5d metallic state. This three-dimensional metallic state hybridizes with a quasi-two-dimensional, strongly correlated state with 3dx2-y2 symmetry in the NiO2 layers. Thus, the infinite-layer nickelate can be regarded as a sibling of the rare earth intermetallics, well-known for heavy Fermion behavior, where the NiO2 correlated layers play an analogous role to the 4f states in rare-earth heavy Fermion compounds. This unique Kondo- or Anderson-lattice-like "oxide-intermetallic" replaces the Mott insulator as the reference state from which superconductivity emerges upon doping., Comment: 28 pages, 5 figures
Published: 2019
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107. I-mode investigation on the Experimental Advanced Superconducting Tokamak

Author: Feng, X., Liu, A. D., Zhou, C., Liu, Z. X., Wang, M. Y., Zhuang, G., Zou, X. L., Wang, T. B., Zhang, Y. Z., Xie, J. L., Liu, H. Q., Zhang, T., Liu, Y., Duan, Y. M., Hu, L. Q., Hu, G. H., Kong, D. F., Wang, S. X., Zhao, H. L., Li, Y. Y., Shao, L. M., Xia, T. Y., Ding, W. X., Lan, T., Li, H., Mao, W. Z., Liu, W. D., Gao, X., Li, J. G., Zhang, S. B., Zhang, X. H., Liu, Z. Y., Qu, C. M., Zhang, S., Zhang, J., Ji, J. X., Fan, H. R., and Zhong, X. M.
Subjects: Physics - Plasma Physics
Abstract: By analyzing large quantities of discharges in the unfavorable ion $ \vec B\times \nabla B $ drift direction, the I-mode operation has been confirmed in EAST tokamak. During the L-mode to I-mode transition, the energy confinement has a prominent improvement by the formation of a high-temperature edge pedestal, while the particle confinement remains almost identical to that in the L-mode. Similar with the I-mode observation on other devices, the $ E_r $ profiles obtained by the eight-channel Doppler backscattering system (DBS8)\cite{J.Q.Hu} show a deeper edge $ E_r $ well in the I-mode than that in the L-mode. And a weak coherent mode (WCM) with the frequency range of 40-150 kHz is observed at the edge plasma with the radial extend of about 2-3 cm. WCM could be observed in both density fluctuation and radial electric field fluctuation, and the bicoherence analyses showed significant couplings between WCM and high frequency turbulence, implying that the $ E_r $ fluctuation and the caused flow shear from WCM should play an important role during I-mode. In addition, a low-frequency oscillation with a frequency range of 5-10 kHz is always accompanied with WCM, where GAM intensity is decreased or disappeared. Many evidences show that the a low-frequency oscillation may be a novel kind of limited cycle oscillation but further investigations are needed to explain the new properties such as the harmonics and obvious magnetical perturbations., Comment: 14 pages, 7 figures
Published: 2019
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108. A large scale passive laser gyroscope for Earth rotation sensing

Author: Liu, K., Zhang, F. L., Li, Z. Y., Feng, X. H., Li, K., Lu, Z. H., Schreiber, K. U., Luo, J., and Zhang, J.
Subjects: Physics - Instrumentation and Detectors, Physics - Optics
Abstract: Earth rotation sensing has many applications in different disciplines, such as for the monitoring of ground motions, the establishment of UT1 and the test of the relativistic Lense-Thirring effect on the ground. We report the development of a 1 m*1 m heterolithic passive resonant gyroscope (PRG). By locking a pair of laser beams to adjacent modes of the square ring cavity in the clockwise and counter-clockwise directions, we achieve a rotation resolution of about 2E-9 rad/s at an integration time of 1000 s. The sensitivity of the PRG for rotations reaches a level of 2E-9 rad/s/rtHz in the 5-100~Hz region, currently limited by the detection noise, residual amplitude modulation and the mechanical instability of the cavity. Our initial results improve the reported rotation sensitivity of the PRGs and indicate that PRGs have a great potential for high-resolution Earth rotation sensing.
Published: 2019
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109. Suvemcitug as second-line treatment of advanced or metastatic solid tumors and with FOLFIRI for pretreated metastatic colorectal cancer: phase Ia/Ib open label, dose-escalation trials

Author: Mao, C., Ji, D., Ding, Y., Zhang, Y., Song, W., Liu, L., Wu, Y., Song, L., Feng, X., Zhang, J., Cao, J., and Xu, N.
Published: 2023
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110. Probing calcium solvation by XAS, MD and DFT calculations

Author: Yang, F, Liu, YS, Feng, X, Qian, K, Kao, LC, Ha, Y, Hahn, NT, Seguin, TJ, Tsige, M, Yang, W, Zavadil, KR, Persson, KA, and Guo, J
Subjects: Chemical Sciences
Abstract: The solvation shell structures of Ca2+ in aqueous and organic solutions probed by calcium L-edge soft X-ray absorption spectroscopy (XAS) and DFT/MD simulations show the coordination number of Ca2+ to be negatively correlated with the electrolyte concentration and the steric hindrance of the solvent molecule. In this work, the calcium L-edge soft XAS demonstrates its sensitivity to the surrounding chemical environment. Additionally, the total electron yield (TEY) mode is surface sensitive because the electron penetration depth is limited to a few nanometers. Thus this study shows its implications for future battery studies, especially for probing the electrolyte/electrode interface for electrochemical reactions under in situ/operando conditions.
Published: 2020

111. In-situ/operando soft x-ray spectroscopy characterization of energy and catalytic materials

Author: Liu, YS, Feng, X, Glans, PA, and Guo, J
Subjects: In-situ/operando, Soft x-ray spectroscopy, Electronic structure, Solar energy conversion, Photoelectrochemical, Interface, Physical Sciences, Chemical Sciences, Engineering, Energy
Abstract: The capabilities of soft x-ray absorption (XAS), soft x-ray emission spectroscopy (XES), resonant inelastic soft x-ray scattering (RIXS), and their application to characterization of solar energy materials are presented. We have discussed some recent developments of in-situ soft x-ray spectroscopy cells, which enable the investigation of critical solid/liquid or solid/gas interfaces in chemical and electrochemical processes under real-world practical conditions. In particular, in-situ soft x-ray spectroscopies can be utilized to probe the formation of intermediate species, charge separation upon illumination of sunlight and electron transfer to the interfacial reactions. A number of examples using soft x-ray spectroscopies to study these solar energy and catalytic materials are discussed to demonstrate how these powerful characterization tools could be helpful to further understand the energy conversion and energy storage systems.
Published: 2020

112. Electronic structure of the parent compound of superconducting infinite-layer nickelates

Author: Hepting, M, Li, D, Jia, CJ, Lu, H, Paris, E, Tseng, Y, Feng, X, Osada, M, Been, E, Hikita, Y, Chuang, Y-D, Hussain, Z, Zhou, KJ, Nag, A, Garcia-Fernandez, M, Rossi, M, Huang, HY, Huang, DJ, Shen, ZX, Schmitt, T, Hwang, HY, Moritz, B, Zaanen, J, Devereaux, TP, and Lee, WS
Subjects: Physical Sciences, Condensed Matter Physics, cond-mat.supr-con, cond-mat.str-el, Nanoscience & Nanotechnology
Abstract: The search continues for nickel oxide-based materials with electronic properties similar to cuprate high-temperature superconductors1-10. The recent discovery of superconductivity in the doped infinite-layer nickelate NdNiO2 (refs. 11,12) has strengthened these efforts. Here, we use X-ray spectroscopy and density functional theory to show that the electronic structure of LaNiO2 and NdNiO2, while similar to the cuprates, includes significant distinctions. Unlike cuprates, the rare-earth spacer layer in the infinite-layer nickelate supports a weakly interacting three-dimensional 5d metallic state, which hybridizes with a quasi-two-dimensional, strongly correlated state with [Formula: see text] symmetry in the NiO2 layers. Thus, the infinite-layer nickelate can be regarded as a sibling of the rare-earth intermetallics13-15, which are well known for heavy fermion behaviour, where the NiO2 correlated layers play an analogous role to the 4f states in rare-earth heavy fermion compounds. This Kondo- or Anderson-lattice-like 'oxide-intermetallic' replaces the Mott insulator as the reference state from which superconductivity emerges upon doping.
Published: 2020

113. Reversible Electrochemical Interface of Mg Metal and Conventional Electrolyte Enabled by Intermediate Adsorption

Author: Wang, H, Feng, X, Chen, Y, Liu, YS, Han, KS, Zhou, M, Engelhard, MH, Murugesan, V, Assary, RS, Liu, TL, Henderson, W, Nie, Z, Gu, M, Xiao, J, Wang, C, Persson, K, Mei, D, Zhang, JG, Mueller, KT, Guo, J, Zavadil, K, Shao, Y, and Liu, J
Abstract: Conventional electrolytes made by mixing simple Mg2+ salts and aprotic solvents, analogous to those in Li-ion batteries, are incompatible with Mg anodes because Mg metal readily reacts with such electrolytes, producing a passivation layer that blocks Mg2+ transport. Here, we report that, through tuning a conventional electrolyte - Mg(TFSI)2 (TFSI- is N(SO2CF3)2-) - with an Mg(BH4)2 cosalt, highly reversible Mg plating/stripping with a high Coulombic efficiency is achieved by neutralizing the first solvation shell of Mg cationic clusters between Mg2+ and TFSI- and enhanced reductive stability of free TFSI-. A critical adsorption step between Mg0 atoms and active Mg cation clusters involving BH4- anions is identified to be the key enabler for reversible Mg plating/stripping through analysis of the distribution of relaxation times (DRT) from operando electrochemical impedance spectroscopy (EIS), operando electrochemical X-ray absorption spectroscopy (XAS), nuclear magnetic resonance (NMR), and density functional theory (DFT) calculations.
Published: 2020

114. Time-resolved RIXS experiment with pulse-by-pulse parallel readout data collection using X-ray free electron laser

Author: Lu, H, Gauthier, A, Hepting, M, Tremsin, AS, Reid, AH, Kirchmann, PS, Shen, ZX, Devereaux, TP, Shao, YC, Feng, X, Coslovich, G, Hussain, Z, Dakovski, GL, Chuang, YD, and Lee, WS
Subjects: Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences
Abstract: Time-resolved resonant inelastic X-ray scattering (RIXS) is one of the developing techniques enabled by the advent of X-ray free electron laser (FEL). It is important to evaluate how the FEL jitter, which is inherent in the self-amplified spontaneous emission process, influences the RIXS measurement. Here, we use a microchannel plate (MCP) based Timepix soft X-ray detector to conduct a time-resolved RIXS measurement at the Ti L3-edge on a charge-density-wave material TiSe2. The fast parallel Timepix readout and single photon sensitivity enable pulse-by-pulse data acquisition and analysis. Due to the FEL jitter, low detection efficiency of spectrometer, and low quantum yield of RIXS process, we find that less than 2% of the X-ray FEL pulses produce signals, preventing acquiring sufficient data statistics while maintaining temporal and energy resolution in this measurement. These limitations can be mitigated by using future X-ray FELs with high repetition rates, approaching MHz such as the European XFEL in Germany and LCLS-II in the USA, as well as by utilizing advanced detectors, such as the prototype used in this study.
Published: 2020

115. The Effect of a Three-Level Remote Alliance on Critical Care in Grassroot Areas: A Multi-Center, Retrospective Study

Author: Feng X, Zhang G, Zhang S, Chen D, Zhou M, Zeng L, and Yang T
Subjects: medical quality, remote alliance, in-place and online, critical care medicine, mortality rate, Medicine (General), R5-920
Abstract: Xiaodong Feng,1,&ast; Guiliang Zhang,1,&ast; Shiyang Zhang,2 Dihong Chen,3 Mengxue Zhou,1 Lihua Zeng,1 Tianmin Yang1 1Department of Critical Care Medicine, Mianzhu People’s Hospital, Mianzhu, 618200, People’s Republic of China; 2Department of Gastroenterology, Mianzhu People’s Hospital, Mianzhu, 618200, People’s Republic of China; 3Mianzhu People’s Hospital, Mianzhu, 618200, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaodong Feng, Department of Critical Care Medicine, Mianzhu People’s Hospital, No. 268, Section 1, Nanjing Avenue, Mianzhu, Sichuan Province, 618200, People’s Republic of China, Tel +8613518265506, Email fxd_3dek1@163.comPurpose: To explore an effective model to promote the homogeneous development of intensive care units (ICUs) in grassroot, impoverished and remote areas.Methods: A three-level remote alliance model (in-place and online assistance) was adopted to guide the cross-talk of ICUs between counties and cities. The observed indicators included the mortality of ICU patients and those with APACHE II scores ≥ 15 points, deep vein thrombosis, ventilator-associated pneumonia, the completion rate of septic shock goals in 3-hour and 6-hour bundles, and the rates of patient transfers.Results: After the implementation of the remote alliance, there was significant reduction in the mortality of ICU patients in the county and city-level tertiary hospitals (7.6% vs 4.5%, P = 0.004; OR = 1.734, 95% CI 1.189– 2.532) and the mortality rates of patients with APACHE II scores ≥ 15 points (11.9% vs 7.1%, P = 0.004; OR = 1.763, 95% CI 1.189– 2.614). There was a significant reduction in the incidence of ventilator-associated pneumonia (0.9% vs 5.0%, P < 0.001) and deep vein thrombosis (52.4% vs 13.6%, P < 0.001). The completion rate of 3-hour bundle therapies for septic shock was significantly improved (95.7% vs 68.4%, P < 0.001), as well as 6-hour bundle therapies for septic shock (97.9% vs 81.6%, P < 0.001). The hospital transfer rate decreased significantly in the grassroots and impoverished areas (2.6% vs 4.7%, P < 0.001).Conclusion: A three-level remote alliance might be helpful in improving the quality of critical care in remote areas and promoting the homogeneous development of disciplines.Keywords: medical quality, remote alliance, in-place and online, critical care medicine, mortality rate
Published: 2022

116. Study on interactive effect of waste seepage and chemical reaction on changes in properties of silty clay

Author: Guo, Y. L., Cao, L. W., Feng, X. H., and Xu, T. Y.
Published: 2022
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117. SYNTHESES, CRYSTAL STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF ZINC COMPLEXES DERIVED FROM 2-AMINO-N′- (PYRIDIN-2-YLMETHYLENE)BENZOHYDRAZIDE

Author: Zhang, L., Feng, X., Gu, Y., Yang, T., Li, X., Yu, H., and You, Z.
Published: 2022
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118. Reconstructing phase space of injection beam based on the measurement of accumulated beam: A novel tomography algorithm and its applications

Author: Liu, H. Y., primary, Xu, S. Y., additional, Li, M. T., additional, Yuan, Y. S., additional, Huang, L. S., additional, Feng, X. Y., additional, and Wang, S., additional
Published: 2024
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119. Study on the mechanism of stone column pile formation

Author: Cheng, Z, primary, Han, S, additional, Feng, X, additional, Zhang, J, additional, Wang, F, additional, and Zhang, D, additional
Published: 2024
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120. Development and calibration of a multi-delay coherence imaging diagnostic on the MAST-U tokamak

Author: Doyle, R. S., primary, Lonigro, N., additional, Allcock, J. S., additional, Silburn, S. A., additional, Turner, M. M., additional, Feng, X., additional, and Leggate, H., additional
Published: 2024
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121. Interaction between GAMs and Mean Flow Shear During SMBI Injection into HL-2A Tokamak

Author: Wang, M. Y., Zhou, C., Liu, A. D., Zhuang, G., Feng, X., Zhang, J., Liu, Z. Y., Ji, J. X., Zhong, X. M., Cheng, J., and Chen, C. Y.
Published: 2022
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122. Global Non-Potential Magnetic Models of the Solar Corona During the March 2015 Eclipse

Author: Yeates, A. R., Amari, T., Contopoulos, I., Feng, X., Mackay, D. H., Mikić, Z., Wiegelmann, T., Hutton, J., Lowder, C. A., Morgan, H., Petrie, G., Rachmeler, L. A., Upton, L. A., Canou, A., Chopin, P., Downs, C., Druckmüller, M., Linker, J. A., Seaton, D. B., and Török, T.
Subjects: Astrophysics - Solar and Stellar Astrophysics
Abstract: Seven different models are applied to the same problem of simulating the Sun's coronal magnetic field during the solar eclipse on 2015 March 20. All of the models are non-potential, allowing for free magnetic energy, but the associated electric currents are developed in significantly different ways. This is not a direct comparison of the coronal modelling techniques, in that the different models also use different photospheric boundary conditions, reflecting the range of approaches currently used in the community. Despite the significant differences, the results show broad agreement in the overall magnetic topology. Among those models with significant volume currents in much of the corona, there is general agreement that the ratio of total to potential magnetic energy should be approximately 1.4. However, there are significant differences in the electric current distributions; while static extrapolations are best able to reproduce active regions, they are unable to recover sheared magnetic fields in filament channels using currently available vector magnetogram data. By contrast, time-evolving simulations can recover the filament channel fields at the expense of not matching the observed vector magnetic fields within active regions. We suggest that, at present, the best approach may be a hybrid model using static extrapolations but with additional energization informed by simplified evolution models. This is demonstrated by one of the models., Comment: 29 pages, 11 figures, accepted for publication in Space Science Reviews
Published: 2018
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123. Micropipette aspiration method for characterizing biological materials with surface energy

Author: Ding, Y., Wang, G. F., Feng, X. Q., and Yu, S. W.
Subjects: Condensed Matter - Soft Condensed Matter
Abstract: Many soft biological tissues possess a considerable surface stress, which plays a significant role in their biophysical functions, but most previous methods for characterizing their mechanical properties have neglected the effects of surface stress. In this work, we investigate the micropipette aspiration to measure the mechanical properties of cells and soft tissues with surface effects. The neo-Hookean constitutive model is adopted to describe the hyperelasticity of the measured biological material, and the surface effect is considered through the finite element method. It is found that when the pipette radius or aspiration length is comparable to the elastocapillary length, surface energy may distinctly alter the aspiration response. Generally, both the aspiration length and the bulk normal stress decreases as surface energy increases, and thus neglecting the surface energy will lead to an overestimation of elastic modulus. Through dimensional analysis and numerical simulations, we provide an explicit relation between the imposed pressure and the aspiration length. This method can be applied to accurately determine the mechanical properties of soft biological tissues and organs, e.g., tumors and embryos., Comment: 19 pages and 6 figures
Published: 2018
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124. Successive X-class flares and coronal mass ejections driven by shearing motion and sunspot rotation in active region NOAA 12673

Author: Yan, X. L., Wang, J. C., Pan, G. M., Kong, D. F., Xue, Z. K., Yang, L. H., Li, Q. L., and Feng, X. S.
Subjects: Astrophysics - Solar and Stellar Astrophysics
Abstract: We present a clear case study on the occurrence of two successive X-class flares including a decade-class flare (X9.3) and two coronal mass ejections (CMEs) triggered by shearing motion and sunspot rotation in active region NOAA 12673 on 2017 September 6. A shearing motion between the main sunspots with opposite polarities started on September 5 and even lasted after the second X-class flare on September 6. Moreover, the main sunspot with negative polarity rotated around its umbral center and another main sunspot with positive polarity also exhibited a slow rotation. The sunspot with negative polarity at the northwest of active region also began to rotate counter-clockwise before the onset of the first X-class flare. The successive formation and eruption of two S-shaped structures were closely related to the counter-clockwise rotation of three sunspots. It is also found that the rotation of sunspots is faster during four hours prior to the onset of the flares than the period before. The existence of a flux rope is found prior to the onset of two flares by using non-linear force free field extrapolation based on the vector magnetograms observed by SDO/HMI. These results suggest that shearing motion and sunspot rotation play an important role in the buildup of the free energy and the formation of flux ropes in the corona which produces solar flares and CMEs., Comment: 28 pages, 12 figures, ApJ
Published: 2018
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125. Machine learning prediction of photocatalytic lignin cleavage of C–C bonds based on density functional theory

Author: Zhang, T., Wu, C., Xing, Z., Zhang, J., Wang, S., Feng, X., Zhu, J., Lu, X., and Mu, L.
Published: 2022
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126. Antimony release and volatilization from rice paddy soils: Field and microcosm study

Author: Caplette, Jaime N., Gfeller, L., Lei, D., Liao, J., Xia, J., Zhang, H., Feng, X., and Mestrot, A.
Published: 2022
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127. Momentum-resolved resonant inelastic soft X-ray scattering (qRIXS) endstation at the ALS

Author: Chuang, YD, Feng, X, Cruz, A, Hanzel, K, Brown, A, Spucces, A, Frano, A, Lee, WS, Kim, J, Chen, YJ, Smith, B, Pepper, JS, Shao, YC, Huang, SW, Wray, LA, Gullikson, E, Shen, ZX, Devereaux, TP, Tremsin, A, Yang, W, Guo, J, Duarte, R, and Hussain, Z
Subjects: Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry, Condensed Matter Physics, Chemical Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural)
Abstract: A momentum resolved resonant inelastic X-ray scattering (qRIXS) experimental station with continuously rotatable spectrometers and parallel detection is designed to operate at different beamlines at synchrotron and free electron laser (FEL) facilities. This endstation, currently located at the Advanced Light Source (ALS), has five emission ports on the experimental chamber for mounting the high-throughput modular soft X-ray spectrometers (MXS) [24]. Coupled to the rotation from the supporting hexapod, the scattered X-rays from 27.5° (forward scattering) to 152.5° (backward scattering) relative to the incident photon beam can be recorded, enabling the momentum-resolved RIXS spectroscopy. The components of this endstation are described in details, and the preliminary RIXS measurements on highly oriented pyrolytic graphite (HOPG) reveal the low energy vibronic excitations from the strong electron-phonon coupling at C K edge around σ* band. The grating upgrade option to enhance the performance at low photon energies is presented and the potential of this spectroscopy is discussed in summary.
Published: 2019

128. Pyrene-Fused Pyrazaacenes with Eight Rectilinearly Arranged Aromatic Rings

Author: Wang, CZ, Feng, X, Elsegood, MRJ, Warwick, TG, Teat, SJ, Redshaw, C, Bi, YS, and Yamato, T
Subjects: pyrenes, azaacenes, density functional calculations, conjugation, photoelectric properties, Organic Chemistry
Abstract: A series of pyrene-fused azaacene-type conjugated molecules containing two pyrazine units and up to eight rectilinearly arranged aromatic rings were prepared by condensation coupling reactions in moderate yields. The geometries and electronic structures associated with 2 and 5 were evaluated by DFT calculations. Photophysical properties indicated that these systems possess delocalized structures, and their optoelectronic properties can be tuned by extending the π-conjugated length and introducing electronic-withdrawing groups. The compounds were thoroughly investigated by XRD studies, electrochemistry and DFT calculations. High thermal stability and tunable energy levels make them excellent candidates as a class of organic molecular materials.
Published: 2019

129. Multifunctional Theranostic Nanoparticles for Enhanced Tumor Targeted Imaging and Synergistic FUS/Chemotherapy on Murine 4T1 Breast Cancer Cell

Author: Kang Z, Yang M, Feng X, Liao H, Zhang Z, and Du Y
Subjects: focused ultrasound, multifunctional nanoparticle, synergistic therapy, phase transformation, acoustic cavitation, breast cancer, Medicine (General), R5-920
Abstract: Zhengyue Kang,1,2,&ast; Min Yang,1,2,&ast; Xiaoling Feng,1,2 Hongjian Liao,1,2 Zhifei Zhang,1,2 Yonghong Du1,2 1State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yonghong Du, State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People’s Republic of China, Tel/Fax +86-23-68485021, Email duyonghong@cqmu.edu.cnPurpose: Triple negative breast cancer (TNBC) is challenging for effective remission due to its very aggressive, extremely metastatic and resistant to conventional chemotherapy. Herein, a multifunctional theranostic nanoparticle was fabricated to enhance tumor targeted imaging and promote focused ultrasound (FUS) ablation and chemotherapy and sonodynamic therapy (SDT). A multi-modal synergistic therapy can improve the therapeutic efficacy and prognosis of TNBC.Methods: AS1411 aptamer modified PEG@PLGA nanoparticles encapsulated with perfluorohexane (PFH) and anti-cancer drug doxorubicin (DOX) were constructed (AS1411-DOX/PFH-PEG@PLGA) to enhance tumor targeted imaging to guide ablation and synergistic effect of FUS/chemotherapy. FUS was utilized to trigger the co-release of doxorubicin and simultaneously PFH phase transition and activate DOX for SDT effect. The physicochemical, phase-changeable imaging capability, biosafety of nanoparticles and multi-mode synergistic effects on growth of TNBC were thoroughly evaluated in vivo and in vitro.Results: The synthesized AS1411-DOX/PFH-PEG@PLGA (A-DPPs) nanoparticles are uniformly round with an average diameter of 306.03 ± 5.35 nm and the zeta potential of − 4.05 ± 0.13 mV, displaying high biosafety and FUS-responsive drug release in vitro and in vivo. AS1411 modified NPs specifically bind to 4T1 cells and elevate the ultrasound contrast agent (UCA) image contrast intensity via PFH phase-transition after FUS exposure. Moreover, the combined treatment of A-DPPs nanoparticles with FUS exhibited significantly higher apoptosis rate, stronger inhibitory effect on 4T1 cell invasion in vitro, induced more reactive oxygen species (ROS), and enhanced anti-tumor effect compared to a single therapy (p < 0.05). Additionally, the joint strategy resulted in more intense cavitation effect and larger ablated areas and reduced energy efficiency factor (EEF) both in vitro and in vivo.Conclusion: The multifunctional AS1411-DOX/PFH-PEG@PLGA nanoparticles can perform as a marvelous synergistic agent for enhanced FUS/chemotherapy, promote real-time contrast enhanced US imaging and improve the therapeutic efficacy and prognosis of TNBC.Keywords: focused ultrasound, multifunctional nanoparticle, synergistic therapy, phase transformation, acoustic cavitation, breast cancer
Published: 2022

130. Whole-genome and transcriptome analysis enhances precision cancer treatment options

Author: Pleasance, E., Bohm, A., Williamson, L.M., Nelson, J.M.T., Shen, Y., Bonakdar, M., Titmuss, E., Csizmok, V., Wee, K., Hosseinzadeh, S., Grisdale, C.J., Reisle, C., Taylor, G.A., Lewis, E., Jones, M.R., Bleile, D., Sadeghi, S., Zhang, W., Davies, A., Pellegrini, B., Wong, T., Bowlby, R., Chan, S.K., Mungall, K.L., Chuah, E., Mungall, A.J., Moore, R.A., Zhao, Y., Deol, B., Fisic, A., Fok, A., Regier, D.A., Weymann, D., Schaeffer, D.F., Young, S., Yip, S., Schrader, K., Levasseur, N., Taylor, S.K., Feng, X., Tinker, A., Savage, K.J., Chia, S., Gelmon, K., Sun, S., Lim, H., Renouf, D.J., Jones, S.J.M., Marra, M.A., and Laskin, J.
Published: 2022
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131. Regulated lithium deposition behavior by an artificial coating of Cu foil for dendrite-free lithium metal batteries

Author: Liu, Y., Xu, Y., Wang, J., Sun, Y., Feng, X., and Xiang, H.
Published: 2022
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132. Post-peak Stress–Strain Curves of Brittle Rocks Under Axial- and Lateral-Strain-Controlled Loadings

Author: Hou, P. Y., Cai, M., Zhang, X. W., and Feng, X. T.
Published: 2022
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133. FLAG Review 2021

Author: Aoki, Y., Blum, T., Colangelo, G., Collins, S., Morte, M. Della, Dimopoulos, P., Dürr, S., Feng, X., Fukaya, H., Golterman, M., Gottlieb, Steven, Gupta, R., Hashimoto, S., Heller, U. M., Herdoiza, G., Hernandez, P., Horsley, R., Jüttner, A., Kaneko, T., Lunghi, E., Meinel, S., Monahan, C., Nicholson, A., Onogi, T., Pena, C., Petreczky, P., Portelli, A., Ramos, A., Sharpe, S. R., Simone, J. N., Simula, S., Sint, S., Sommer, R., Tantalo, N., Van de Water, R., Wenger, U., and Wittig, H.
Published: 2022
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134. Data publication: Tunable Crystallinity and Electron Conduction in Wavy 2D Conjugated Metal-Organic Frameworks via Halogen Substitution

Author: Jastrzembski, K., Zhang, Y., Lu, Y., Sporrer, L., Pohl, D., Rellinghaus, B., Waentig, A. L., Zhang, H., Mücke, D., Fu, S., Polozij, M., Li, X., Zhang, J., Wang, M., Morag, A., Yu, M., Mateo-Alonso, A., Wang, H. I., Bonn, M., Kaiser, U., (0000-0003-2379-6251) Heine, T., Dong, R., Feng, X., Jastrzembski, K., Zhang, Y., Lu, Y., Sporrer, L., Pohl, D., Rellinghaus, B., Waentig, A. L., Zhang, H., Mücke, D., Fu, S., Polozij, M., Li, X., Zhang, J., Wang, M., Morag, A., Yu, M., Mateo-Alonso, A., Wang, H. I., Bonn, M., Kaiser, U., (0000-0003-2379-6251) Heine, T., Dong, R., and Feng, X.
Abstract: SinglePoint + band structure calculations for Cu3(HF-HH-cHBC)2 material using VASP software.
Published: 2024

135. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

Author: Vollset, S, Ababneh, H, Abate, Y, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, A, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdullahi, A, Abebe, M, Abiodun, O, Aboagye, R, Abolhassani, H, Abouzid, M, Aboye, G, Abreu, L, Absalan, A, Abualruz, H, Abubakar, B, Abukhadijah, H, Addolorato, G, Adekanmbi, V, Adetunji, C, Adetunji, J, Adeyeoluwa, T, Adha, R, Adhikary, R, Adnani, Q, Adzigbli, L, Afrashteh, F, Afzal, M, Afzal, S, Agbozo, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, B, Ahlstrom, A, Ahmad, A, Ahmad, F, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, H, Ahmed, S, Akinosoglou, K, Akkaif, M, Akrami, A, Akter, E, Al Awaidy, S, Al Hasan, S, Al Mosa, A, Al Ta'ani, O, Al Zaabi, O, Alahdab, F, Alajlani, M, Al-Ajlouni, Y, Alalalmeh, S, Al-Aly, Z, Alam, K, Alam, N, Alam, T, Alam, Z, Al-amer, R, Alanezi, F, Alanzi, T, Albakri, A, Aldhaleei, W, Aldridge, R, Alemohammad, S, Alemu, Y, Al-Gheethi, A, Al-Hanawi, M, Ali, A, Ali, I, Ali, M, Ali, R, Ali, S, Ali, V, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, S, Aljunid, S, Alla, F, Almazan, J, Al-Mekhlafi, H, Alqutaibi, A, Alrawashdeh, A, Alrousan, S, Al-Sabah, S, Alsabri, M, Altaany, Z, Al-Tammemi, A, Al-Tawfiq, J, Altirkawi, K, Aluh, D, Alvis-Guzman, N, Al-Wardat, M, Al-Worafi, Y, Aly, H, Alyahya, M, Alzoubi, K, Al-Zyoud, W, Amani, R, Ameyaw, E, Amin, T, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, M, Amu, H, Amugsi, D, Ancuceanu, R, Anderlini, D, Anderson, D, Andrade, P, Andrei, C, Andrei, T, Andrews, E, Anil, A, Anil, S, Anoushiravani, A, Antony, C, Antriyandarti, E, Anuoluwa, B, Anvari, S, Anyasodor, A, Appiah, F, Aquilano, M, Arab, J, Arabloo, J, Arafa, E, Arafat, M, Aravkin, A, Ardekani, A, Areda, D, Aregawi, B, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, A, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, S, Atorkey, P, Atout, M, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, A, Ayatollahi, H, Ayuso-Mateos, J, Azadnajafabad, S, Azeez, F, Azevedo, R, Badar, M, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, J, Bako, A, Balakrishnan, S, Balcha, W, Baltatu, O, Barchitta, M, Bardideh, E, Barker-Collo, S, Bärnighausen, T, Barqawi, H, Barteit, S, Basiru, A, Basso, J, Bastan, M, Basu, S, Bauckneht, M, Baune, B, Bayati, M, Bayileyegn, N, Behnoush, A, Behzadi, P, Beiranvand, M, Bello, O, Belo, L, Beloukas, A, Bemanalizadeh, M, Bensenor, I, Benzian, H, Beran, A, Berezvai, Z, Bernstein, R, Bettencourt, P, Beyene, K, Beyene, M, Bhagat, D, Bhagavathula, A, Bhala, N, Bhandari, D, Bharadwaj, R, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhattacharjee, N, Bhatti, G, Bhatti, J, Bhatti, M, Bhuiyan, M, Bisignano, C, Biswas, B, Bjørge, T, Bodolica, V, Bodunrin, A, Bonakdar Hashemi, M, Bora Basara, B, Borhany, H, Bosoka, S, Botero Carvajal, A, Bouaoud, S, Boufous, S, Boxe, C, Boyko, E, Brady, O, Braithwaite, D, Brauer, M, Brazo-Sayavera, J, Brenner, H, Brown, C, Browne, A, Brugha, T, Bryazka, D, Bulamu, N, Buonsenso, D, Burkart, K, Burns, R, Busse, R, Bustanji, Y, Butt, Z, Caetano dos Santos, F, Çakmak Barsbay, M, Calina, D, Campos, L, Cao, S, Capodici, A, Cárdenas, R, Carreras, G, Carugno, A, Carvalho, M, Castaldelli-Maia, J, Castelpietra, G, Cattaruzza, M, Caye, A, Cegolon, L, Cembranel, F, Cenko, E, Cerin, E, Chadban, S, Chadwick, J, Chakraborty, C, Chakraborty, S, Chalek, J, Chan, J, Chandika, R, Chandy, S, Charan, J, Chaudhary, A, Chaurasia, A, Chen, A, Chen, H, Chen, M, Chen, S, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Chimoriya, R, Ching, P, Chirinos-Caceres, J, Chitheer, A, Cho, D, Cho, W, Choi, D, Chong, B, Chong, C, Chopra, H, Chu, D, Chung, E, Chutiyami, M, Clayton, J, Cogen, R, Cohen, A, Columbus, A, Comfort, H, Conde, J, Connolly, J, Cooper, E, Cortese, S, Cruz-Martins, N, da Silva, A, Dadras, O, Dai, X, Dai, Z, Dalton, B, Damiani, G, Dandona, L, Dandona, R, Das, J, Das, S, Dash, N, Davletov, K, De la Hoz, F, De Leo, D, Debopadhaya, S, Delgado-Enciso, I, Denova-Gutiérrez, E, Dervenis, N, Desai, H, Devanbu, V, Dewan, S, Dhama, K, Dhane, A, Dhingra, S, Dias da Silva, D, Diaz, D, Diaz, L, Diaz, M, Dima, A, Ding, D, Do, T, do Prado, C, Dodangeh, M, Doegah, P, Dohare, S, Dong, W, D'Oria, M, Doshi, R, Dowou, R, Dsouza, H, Dsouza, V, Dube, J, Dumith, S, Duncan, B, Duraes, A, Duraisamy, S, Durojaiye, O, Dushpanova, A, Dutta, S, Dzianach, P, Dziedzic, A, Eboreime, E, Ebrahimi, A, Ebrahimi Kalan, M, Edinur, H, Efendi, F, Eikemo, T, Eini, E, Ekundayo, T, El Arab, R, El Sayed, I, Elamin, O, Elemam, N, Elgohary, G, Elhadi, M, Elmeligy, O, Elmoselhi, A, Elshaer, M, Elsohaby, I, Eltahir, M, Emeto, T, Eshrati, B, Eslami, M, Esmaeili, Z, Fabin, N, Fagbamigbe, A, Fagbule, O, Falzone, L, Fareed, M, Farinha, C, Faris, M, Faro, A, Fasihi, K, Fatehizadeh, A, Fauk, N, Fazylov, T, Feigin, V, Fekadu, G, Feng, X, Fereshtehnejad, S, Ferrara, P, Ferreira, N, Firew, B, Fischer, F, Fitriana, I, Flavel, J, Flor, L, Folayan, M, Foley, K, Fonzo, M, Force, L, Foschi, M, Freitas, A, Fridayani, N, Fukutaki, K, Furtado, J, Fux, B, Gaal, P, Gadanya, M, Gallus, S, Ganesan, B, Ganiyani, M, Gautam, R, Gebi, T, Gebregergis, M, Gebrehiwot, M, Getacher, L, Getahun, G, Gething, P, Ghadimi, D, Ghadirian, F, Ghafarian, S, Ghailan, K, Ghasemi, M, Ghasempour Dabaghi, G, Ghazy, R, Ghoba, S, Gholami, E, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Ghorbani Vajargah, P, Ghotbi, E, Gil, A, Gill, T, Girmay, A, Glasbey, J, Glushkova, E, Gnedovskaya, E, Göbölös, L, Goldust, M, Goleij, P, Golinelli, D, Gopalani, S, Goulart, A, Gouravani, M, Goyal, A, Grivna, M, Grosso, G, Guarducci, G, Gubari, M, Guicciardi, S, Guimarães, R, Gulati, S, Gulisashvili, D, Gunawardane, D, Guo, C, Gupta, A, Gupta, R, Gupta, S, Gupta, V, Haakenstad, A, Hadi, N, Haep, N, Hafiz, A, Haghmorad, D, Haile, D, Hajj Ali, A, Haj-Mirzaian, A, Halboub, E, Haller, S, Halwani, R, Hamagharib Abdullah, K, Hamdy, N, Hamoudi, R, Hanifi, N, Hankey, G, Haq, Z, Haque, 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Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Yu, Elaine A, Yu, Yong, Yuan, Chun-Wei, Yusuf, Hadiza, Zafar, Uzma, Zafari, Nima, Zahid, Mondal Hasan, Zakham, Fathiah, Zaki, Nazar, Zerfu, Taddese Alemu, Zhang, Haijun, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhiqiang, Zhao, Xiu-Ju George, Zhao, Yang, Zhao, Zhongyi, Zhong, Chenwen, Zhou, Bolun, Zhou, Juexiao, Zhou, Shangcheng, Zhu, Bin, Zhumagaliuly, Abzal, Zielińska, Magdalena, Zoghi, Ghazal, Zumla, Alimuddin, Zyoud, Sa'ed H, Zyoud, Samer H, Smith, Amanda E, and Murray, Christopher J L
Published: 2024

136. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Naghavi, M, Ong, K, Aali, A, Ababneh, H, Abate, Y, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdollahifar, M, Abdoun, M, Abdulah, D, Abdullahi, A, Abebe, M, Abebe, S, Abedi, A, Abegaz, K, Abhilash, E, Abidi, H, Abiodun, O, Aboagye, R, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, G, Abreu, L, Abrha, W, Abtahi, D, Abu Rumeileh, S, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, N, Aburuz, S, Abu-Zaid, A, Accrombessi, M, Adal, T, Adamu, A, Addo, I, Addolorato, G, Adebiyi, A, Adekanmbi, V, Adepoju, A, Adetunji, C, Adetunji, J, Adeyeoluwa, T, Adeyinka, D, Adeyomoye, O, Admass, B, Adnani, Q, Adra, S, Afolabi, A, Afzal, M, Afzal, S, Agampodi, S, Agasthi, P, Aggarwal, M, Aghamiri, S, Agide, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, M, Ahmad, S, Ahmad, T, Ahmadi, K, Ahmadzade, A, Ahmed, A, Ahmed, H, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Akara, E, Akbarialiabad, H, Akinosoglou, K, Akinyemiju, T, Akkaif, M, Akyirem, S, Al Hamad, H, Al Hasan, S, Alahdab, F, Alalalmeh, S, Alalwan, T, Al-Aly, Z, Alam, K, Alam, M, Alam, N, Al-amer, R, Alanezi, F, Alanzi, T, Al-Azzam, S, Albakri, A, Albashtawy, M, Albataineh, M, Alcalde-Rabanal, J, Aldawsari, K, Aldhaleei, W, Aldridge, R, Alema, H, Alemayohu, M, Alemi, S, Alemu, Y, Al-Gheethi, A, Alhabib, K, Alhalaiqa, F, Al-Hanawi, M, Ali, A, Ali, L, Ali, M, Ali, R, Ali, S, Alicandro, G, Alif, S, Alikhani, R, Alimohamadi, Y, Aliyi, A, Aljasir, M, Aljunid, S, Alla, F, Allebeck, P, Al-Marwani, S, Al-Maweri, S, Almazan, J, Al-Mekhlafi, H, Almidani, L, Almidani, O, Alomari, M, Al-Omari, B, Alonso, J, Alqahtani, J, Alqalyoobi, S, Alqutaibi, A, Al-Sabah, S, Altaany, Z, Altaf, A, Al-Tawfiq, J, Altirkawi, K, Aluh, D, Alvis-Guzman, N, Alwafi, H, Al-Worafi, Y, Aly, H, Aly, S, Alzoubi, K, Amani, R, Amare, A, Amegbor, P, Ameyaw, E, Amin, T, Amindarolzarbi, A, 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Published: 2024

137. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

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Published: 2024

138. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

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Yadollahpour, Ali, Yaghoubi, Sajad, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Yazdanpanah, Mohammad Hosein, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesuf, Subah Abderehim, Yezli, Saber, Yiğit, Arzu, Yiğit, Vahit, Yigzaw, Zeamanuel Anteneh, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Yu, Yong, Yusuf, Hadiza, Zahid, Mondal Hasan, Zakham, Fathiah, Zaki, Leila, Zaki, Nazar, Zaman, Burhan Abdullah, Zamora, Nelson, Zand, Ramin, Zandieh, Ghazal G Z, Zar, Heather J, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zhang, Haijun, Zhang, Ning, Zhang, Yunquan, Zhao, Hanqing, Zhong, Chenwen, Zhong, Panliang, Zhou, Juexiao, Zhu, Zhaohua, Ziafati, Makan, Zielińska, Magdalena, Zimsen, Stephanie R M, Zoladl, Mohammad, Zumla, Alimuddin, Zyoud, Samer H, Vos, Theo, and Murray, Christopher J L
Published: 2024

139. Sources, compositions, spatio-temporal distributions, and human health risks of bioaerosols: A review

Author: Feng, X., Xu, X., Yao, X., Zhao, Y., Tang, Y., Zhao, Z., Wei, Y., Mehmood, Tariq, Luo, X.-S., Feng, X., Xu, X., Yao, X., Zhao, Y., Tang, Y., Zhao, Z., Wei, Y., Mehmood, Tariq, and Luo, X.-S.
Abstract: Bioaerosols are a crucial part of atmospheric particulate matter (aerosols), combining physical and chemical aerosol properties with biological characteristics. They play a vital role in global ecosystems, climate change, air quality, and public health, and serve as an important pathway for transmitting respiratory infectious diseases. Major pandemics like H1N1, SARS, MERS, and COVID-19 have had far-reaching impacts on both human life and the global economy. Understanding the nexus ‘sources-spatial and temporal distributions-influencing factors-health risks’ of bioaerosols is crucial for developing strategies to mitigate pollution and prevent the spread of related epidemics. This review provides an overview of the primary sources of bioaerosols and their analysis methods, detailing the spatial and temporal distribution characteristics of their community structure across daily, annual, latitudinal gradient, vertical gradient, and urbanized environmental gradient variations. The study also elucidates the impact of land use types, meteorological conditions, climate change, and air quality on bioaerosols. It emphasizes the main exposure pathways, evaluation models, and constraints of pathogenic bioaerosols. Finally, this overview offers an outlook on the future development of bioaerosols and presents corresponding recommendations.
Published: 2024

140. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

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Alemohammad, SY, Alemu, YM, Al-Gheethi, AAS, Al-Hanawi, MK, Ali, A, Ali, I, Ali, MU, Ali, R, Ali, SSS, Ali, VE, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Almazan, JU, Al-Mekhlafi, HM, Alqutaibi, AY, Alrawashdeh, A, Alrousan, SM, Al-Sabah, SK, Alsabri, MA, Altaany, Z, Al-Tammemi, AB, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Alyahya, MS, Alzoubi, KH, Al-Zyoud, W, Amani, R, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Andrews, EA, Anil, A, Anil, S, Anoushiravani, A, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, S, Anyasodor, AE, Appiah, F, Aquilano, M, Arab, JP, Arabloo, J, Arafa, EA, Arafat, M, Aravkin, AY, Ardekani, A, Areda, D, Aregawi, BB, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, AA, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, SS, 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Published: 2024

141. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Ferrari, AJ, Santomauro, DF, Aali, A, Abate, YH, Abbafati, C, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdollahi, A, Abdullahi, A, Abegaz, KH, Abeldaño Zuñiga, RA, Aboagye, RG, Abolhassani, H, Abreu, LG, Abualruz, H, Abu-Gharbieh, E, Abu-Rmeileh, NME, Ackerman, IN, Addo, IY, Addolorato, G, Adebiyi, AO, Adepoju, AV, Adewuyi, HO, Afyouni, S, Afzal, S, Agodi, A, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, S, Ahmed, A, Ahmed, LA, Ahmed, MB, Ajami, M, Akinosoglou, K, Akkaif, MA, Al Hasan, SM, Alalalmeh, SO, Al-Aly, Z, Albashtawy, M, Aldridge, RW, Alemu, MD, Alemu, YM, Alene, KA, Al-Gheethi, AAS, Alharrasi, M, Alhassan, RK, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Alomari, MA, Al-Omari, B, Altaany, Z, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, S, Alzoubi, KH, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Ansari, H, Antony, CM, Anwar, S, Anwar, SL, Anwer, R, Anyanwu, PE, Arab, JP, Arabloo, J, Arafat, M, Araki, DT, Aravkin, AY, Arkew, M, Armocida, B, Arndt, MB, Arooj, M, Artamonov, AA, Aruleba, RT, Arumugam, A, Ashbaugh, C, Ashemo, MY, Ashraf, M, Asika, MO, Askari, E, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Awotidebe, AW, Awuviry-Newton, K, Ayala Quintanilla, BP, Ayuso-Mateos, JL, Azadnajafabad, S, Azevedo, RMS, Babu, AS, Badar, M, Badiye, AD, Baghdadi, S, Bagheri, N, Bah, S, Bai, R, Baker, JL, Bakkannavar, SM, Bako, AT, Balakrishnan, S, Bam, K, Banik, PC, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Barqawi, HJ, Barrow, A, Barteit, S, Barua, L, Bashiri Aliabadi, S, Basiru, A, Basu, S, Bathini, PP, Batra, K, Baune, BT, Bayileyegn, NS, Behnam, B, Behnoush, AH, Beiranvand, M, Bejarano Ramirez, DF, Bell, ML, Bello, OO, Beloukas, A, Bensenor, IM, Berezvai, Z, Bernabe, E, Bernstein, RS, Bettencourt, PJG, Bhagavathula, AS, Bhala, N, Bhandari, D, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhatti, R, Bhutta, ZA, Bikbov, B, Bishai, JD, Bisignano, C, Bitra, VR, Bjørge, T, Bodolica, V, Bodunrin, AO, Bogale, EK, Bonakdar Hashemi, M, Bonny, A, Bora Basara, B, Borhany, H, Boxe, C, Brady, OJ, Bragazzi, NL, Braithwaite, D, Brant, LC, Brauer, M, Breitner, S, Brenner, H, Brown, J, Brugha, T, Bulamu, NB, Buonsenso, D, Burkart, K, Burns, RA, Busse, R, Bustanji, Y, Butt, ZA, Byun, J, Caetano dos Santos, FL, Calina, D, Cámera, LA, Campos-Nonato, IR, Cao, C, Capodici, A, Carr, S, Carreras, G, Carugno, A, Carvalho, M, Castaldelli-Maia, JM, Castañeda-Orjuela, CA, Castelpietra, G, Catapano, AL, Cattaruzza, MS, Caye, A, Cegolon, L, Cembranel, F, Cenderadewi, M, Cerin, E, Chakraborty, PA, Chan, JSK, Chan, RNC, Chandika, RM, Chandrasekar, EK, Charalampous, P, Chattu, VK, Chatzimavridou-Grigoriadou, V, Chen, AW, Chen, A-T, Chen, CS, Chen, H, Chen, NM, Cheng, ETW, Chimed-Ochir, O, Chimoriya, R, Ching, PR, Cho, WCS, Choi, S, Chong, B, Chong, YY, Choudhari, SG, Chowdhury, R, Christensen, SWM, Chu, D-T, Chukwu, IS, Chung, E, Chutiyami, M, Claassens, MM, Cogen, RM, Columbus, A, Conde, J, Cortesi, PA, Cousin, E, Criqui, MH, Cruz-Martins, N, Dadras, O, Dai, S, Dai, X, Dai, Z, Dalaba, MA, Damiani, G, Das, JK, Das, S, Dashti, M, Dávila-Cervantes, CA, Davletov, K, De Leo, D, Debele, AT, Debopadhaya, S, DeCleene, NK, Deeba, F, Degenhardt, L, Del Bo', C, Delgado-Enciso, I, Demetriades, AK, Denova-Gutiérrez, E, Dervenis, N, Desai, HD, Desai, R, Deuba, K, Dhama, K, Dharmaratne, SD, Dhingra, S, Dias da Silva, D, Diaz, D, Diaz, LA, Diaz, MJ, Dima, A, Ding, DD, Dirac, MA, Do, THP, do Prado, CB, Dohare, S, Dominguez, R-MV, Dong, W, Dongarwar, D, D'Oria, M, Dorsey, ER, Doshmangir, L, Dowou, RK, Driscoll, TR, Dsouza, HL, Dsouza, V, Dube, J, Dumith, SC, Duncan, BB, Duraes, AR, Duraisamy, S, Durojaiye, OC, Dzianach, PA, Dziedzic, AM, Eboreime, E, Ebrahimi, A, Edinur, HA, 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Le, LKD, Le, NHH, Le, TDT, Leasher, JL, Ledda, C, Lee, M, Lee, PH, Lee, S-W, Lee, SW, Lee, W-C, Lee, YH, LeGrand, KE, Lenzi, J, Leong, E, Leung, J, Li, M-C, Li, W, Li, X, Li, Y, Lim, L-L, Lim, SS, Lindstrom, M, Linn, S, Liu, G, Liu, R, Liu, S, Liu, W, Liu, X, Llanaj, E, Lo, C-H, López-Bueno, R, Loreche, AM, Lorenzovici, L, Lozano, R, Lubinda, J, Lucchetti, G, Lunevicius, R, Lusk, JB, lv, H, Ma, ZF, Machairas, N, Madureira-Carvalho, ÁM, Magaña Gómez, JA, Maghazachi, AA, Maharjan, P, Mahasha, PW, Maheri, M, Mahjoub, S, Mahmoud, MA, Mahmoudi, E, Majeed, A, Makris, KC, Malakan Rad, E, Malhotra, K, Malik, AA, Malik, I, Malta, DC, Manla, Y, Mansour, A, Mansouri, P, Mansournia, MA, Mantilla Herrera, AM, Mantovani, LG, Manu, E, Marateb, HR, Mardi, P, Martinez, G, Martinez-Piedra, R, Martini, D, Martins-Melo, FR, Martorell, M, Marx, W, Maryam, S, Marzo, RR, Mathangasinghe, Y, Mathieson, S, Mathioudakis, AG, Mattumpuram, J, Maugeri, A, Mayeli, M, Mazidi, M, Mazzotti, A, McGrath, JJ, McKee, 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RC, Remuzzi, G, Renzaho, AMN, Reshmi, B, Reyes, LF, Rezaei, N, Rezaei Hachesu, P, Rezaeian, M, Rickard, J, Rodrigues, CF, Rodriguez, JAB, Roever, L, Ronfani, L, Roshandel, G, Rotimi, K, Rout, HS, Roy, B, Roy, N, Roy, P, Rubagotti, E, S N, C, Saad, AMA, Saber-Ayad, MM, Sabour, S, Sacco, S, Sachdev, PS, Saddik, B, Saddler, A, Sadee, BA, Sadeghi, E, Sadeghi, M, Saeb, MR, Saeed, U, Safi, SZ, Sagar, R, Sagoe, D, Saif, Z, Sajid, MR, Sakshaug, JW, Salam, N, Salami, AA, Salaroli, LB, Saleh, MA, Salem, MR, Salem, MZY, Sallam, M, Samadzadeh, S, Samargandy, S, Samodra, YL, Samy, AM, Sanabria, J, Sanna, F, Santos, IS, Santric-Milicevic, MM, Sarasmita, MA, Sarikhani, Y, Sarmiento-Suárez, R, Sarode, GS, Sarode, SC, Sarveazad, A, Sathian, B, Sathyanarayan, A, Satpathy, M, Sawhney, M, Scarmeas, N, Schaarschmidt, BM, Schmidt, MI, Schneider, IJC, Schumacher, AE, Schwebel, DC, Schwendicke, F, Sedighi, M, Senapati, S, Senthilkumaran, S, Sepanlou, SG, Sethi, Y, Setoguchi, S, Seylani, A, Shadid, J, Shafie, M, Shah, H, Shah, NS, Shah, PA, Shahbandi, A, Shahid, S, Shahid, W, Shahwan, MJ, Shaikh, MA, Shakeri, A, Shalash, AS, Sham, S, Shamim, MA, Shamshirgaran, MA, Shamsi, MA, Shanawaz, M, Shankar, A, Shannawaz, M, Sharath, M, Sharifan, A, Sharifi-Rad, J, Sharma, M, Sharma, R, Sharma, S, Sharma, U, Sharma, V, Shastry, RP, Shavandi, A, Shayan, AM, Shayan, M, Shehabeldine, AME, Shetty, PH, Shibuya, K, Shifa, JE, Shiferaw, D, Shiferaw, WS, Shigematsu, M, Shiri, R, Shitaye, NA, Shittu, A, Shivakumar, KM, Shivarov, V, Shokati Eshkiki, Z, Shool, S, Shrestha, S, Shuval, K, Sibhat, MM, Siddig, EE, Sigfusdottir, ID, Silva, DAS, Silva, JP, Silva, LMLR, Silva, S, Simpson, CR, Singal, A, Singh, A, Singh, BB, Singh, H, Singh, JA, Singh, M, Singh, P, Skou, ST, Sleet, DA, Slepak, ELN, Solanki, R, Soliman, SSM, Song, S, Song, Y, Sorensen, RJD, Soriano, JB, Soyiri, IN, Spartalis, M, Sreeramareddy, CT, Stark, BA, Starodubova, AV, Stein, C, Stein, DJ, Steiner, C, Steiner, TJ, Steinmetz, JD, Steiropoulos, P, 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Unsworth, CA, Upadhyay, E, Urso, D, Usman, JS, Vahabi, SM, Vaithinathan, AG, Van den Eynde, J, Varga, O, Varma, RP, Vart, P, Vasankari, TJ, Vasic, M, Vaziri, S, Vellingiri, B, Venketasubramanian, N, Veroux, M, Verras, G-I, Vervoort, D, Villafañe, JH, Violante, FS, Vlassov, V, Vollset, SE, Volovat, SR, Vongpradith, A, Waheed, Y, Wang, C, Wang, F, Wang, N, Wang, S, Wang, Y, Wang, Y-P, Ward, P, Wassie, EG, Weaver, MR, Weerakoon, KG, Weintraub, RG, Weiss, DJ, Weldemariam, AH, Wells, KM, Wen, YF, Whisnant, JL, Whiteford, HA, Wiangkham, T, Wickramasinghe, DP, Wickramasinghe, ND, Wilandika, A, Wilkerson, C, Willeit, P, Wimo, A, Woldegebreal, DH, Wolf, AW, Wong, YJ, Woolf, AD, Wu, C, Wu, F, Wu, X, Wu, Z, Wulf Hanson, S, Xia, Y, Xiao, H, Xu, X, Xu, YY, Yadav, L, Yadollahpour, A, Yaghoubi, S, Yamagishi, K, Yang, L, Yano, Y, Yao, Y, Yaribeygi, H, Yazdanpanah, MH, Ye, P, Yehualashet, SS, Yesuf, SA, Yezli, S, Yiğit, A, Yiğit, V, Yigzaw, ZA, Yismaw, Y, Yon, DK, Yonemoto, N, Younis, MZ, Yu, C, Yu, Y, Yusuf, H, Zahid, MH, Zakham, F, Zaki, L, Zaki, N, Zaman, BA, Zamora, N, Zand, R, Zandieh, GGZ, Zar, HJ, Zarrintan, A, Zastrozhin, MS, Zhang, H, Zhang, N, Zhang, Y, Zhao, H, Zhong, C, Zhong, P, Zhou, J, Zhu, Z, Ziafati, M, Zielińska, M, Zimsen, SRM, Zoladl, M, Zumla, A, Zyoud, SH, Vos, T, and Murray, CJL
Published: 2024

142. Size, distribution, and vulnerability of the global soil inorganic carbon

Author: Huang, Y., Song, X., Wang, Y.-P., Canadell, J.G., Luo, Y., Ciais, P., Chen, A., Hong, S., Wang, Y., Tao, F., Li, W., Xu, Y., Mirzaeitalarposhti, R., Elbasiouny, H., Savin, I., Shchepashchenko, D., Rossel, R., Goll, D., Chang, J., Houlton, B., Wu, H., Yang, F., Feng, X., Chen, Y., Liu, Y., Niu, S., Zhang, G.-L., Huang, Y., Song, X., Wang, Y.-P., Canadell, J.G., Luo, Y., Ciais, P., Chen, A., Hong, S., Wang, Y., Tao, F., Li, W., Xu, Y., Mirzaeitalarposhti, R., Elbasiouny, H., Savin, I., Shchepashchenko, D., Rossel, R., Goll, D., Chang, J., Houlton, B., Wu, H., Yang, F., Feng, X., Chen, Y., Liu, Y., Niu, S., and Zhang, G.-L.
Abstract: Global estimates of the size, distribution, and vulnerability of soil inorganic carbon (SIC) remain largely unquantified. By compiling 223,593 field-based measurements and developing machine-learning models, we report that global soils store 2305 ± 636 (±1 SD) billion tonnes of carbon as SIC over the top 2-meter depth. Under future scenarios, soil acidification associated with nitrogen additions to terrestrial ecosystems will reduce global SIC (0.3 meters) up to 23 billion tonnes of carbon over the next 30 years, with India and China being the most affected. Our synthesis of present-day land-water carbon inventories and inland-water carbonate chemistry reveals that at least 1.13 ± 0.33 billion tonnes of inorganic carbon is lost to inland-waters through soils annually, resulting in large but overlooked impacts on atmospheric and hydrospheric carbon dynamics.
Published: 2024
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143. Chiral behavior of $K \to \pi l \nu$ decay form factors in lattice QCD with exact chiral symmetry

Author: JLQCD Collaboration, Aoki, S., Cossu, G., Feng, X., Fukaya, H., Hashimoto, S., Kaneko, T., Noaki, J., and Onogi, T.
Subjects: High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract: We calculate the form factors of the $K \to \pi l \nu$ semileptonic decays in three-flavor lattice QCD, and study their chiral behavior as a function of the momentum transfer and the Nambu-Goldstone boson masses. Chiral symmetry is exactly preserved by using the overlap quark action, which enables us to directly compare the lattice data with chiral perturbation theory (ChPT). We generate gauge ensembles at a lattice spacing of 0.11fm with four pion masses covering 290-540 MeV and a strange quark mass m_s close to its physical value. By using the all-to-all quark propagator, we calculate the vector and scalar form factors with high precision. Their dependence on m_s and the momentum transfer is studied by using the reweighting technique and the twisted boundary conditions for the quark fields. We compare the results for the semileptonic form factors with ChPT at next-to-next-to leading order in detail. While many low-energy constants appear at this order, we make use of our data of the light meson electromagnetic form factors in order to control the chiral extrapolation. We determine the normalization of the form factors as f_+(0) = 0.9636(36)(+57/-35), and observe reasonable agreement of their shape with experiment., Comment: 34 pages, 13 figures
Published: 2017

144. The Predominance of Proteobacteria and Cyanobacteria in the Cycas dolichophylla Coralloid Roots Revealed by 16S rRNA Metabarcoding

Author: Zheng, Y., Chiang, T.-Y., Huang, Ch-Li, Feng, X.-Y., Yrjälä, K., and Gong, X.
Published: 2021
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145. Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.

Author: Hu, J, Feng, X, Valdearcos, M, Lutrin, D, Uchida, Y, Koliwad, SK, and Maze, M
Subjects: Blood-Brain Barrier, Hippocampus, Microglia, Macrophages, Animals, Mice, Inbred C57BL, Mice, Disease Models, Animal, Interleukin-6, Behavior, Animal, Male, Perioperative Period, Neurocognitive Disorders, cognitive dysfunction, cytokines, interleukin-6, surgery, tocilizumab, Neurosciences, Good Health and Well Being, Clinical Sciences, Anesthesiology
Abstract: BACKGROUND:Perioperative neurocognitive disorders (PND) result in long-term morbidity and mortality with no effective interventions available. Because interleukin-6 (IL-6), a pro-inflammatory cytokine, is consistently up-regulated by trauma, including after surgery, we determined whether IL-6 is a putative therapeutic target for PND in a mouse model. METHODS:Following institutional approval, adult (12-14 weeks) male C57/Bl6 mice were pretreated with the IL-6 receptor (IL6R) blocking antibody tocilizumab prior to open tibia fracture with internal fixation under isoflurane anaesthesia. Inflammatory and behavioural responses in a trace fear conditioning (TFC) paradigm were assessed postoperatively. Separately, the effects of IL-6 administration or of depletion of bone marrow-derived monocytes (BM-DMs) with clodrolip on the inflammatory and behavioural responses were assessed. Blood brain barrier disruption, hippocampal microglial activation, and infiltration of BM-DMs were each assessed following IL-6 administration. RESULTS:The surgery-induced decrement in freezing time in the TFC assay, indicative of cognitive decline, was attenuated by tocilizumab (P
Published: 2018

146. IEA EBC Annex 66: Definition and simulation of occupant behavior in buildings

Author: Yan, D, Hong, T, Dong, B, Mahdavi, A, D'Oca, S, Gaetani, I, and Feng, X
Subjects: Occupant behavior, Energy modeling, Interdisciplinary approach, Energy use, IEA EBC Annex 66, Building performance, Building & Construction, Engineering, Built Environment and Design
Abstract: More than 30% of the total primary energy in the world is consumed in buildings. It is crucial to reduce building energy consumption in order to preserve energy resources and mitigate global climate change. Building performance simulations have been widely used for the estimation and optimization of building performance, providing reference values for the assessment of building energy consumption and the effects of energy-saving technologies. Among the various factors influencing building energy consumption, occupant behavior has drawn increasing attention. Occupant behavior includes occupant presence, movement, and interaction with building energy devices and systems. However, there are gaps in occupant behavior modeling as different energy modelers have employed varied data and tools to simulate occupant behavior, therefore producing different and incomparable results. Aiming to address these gaps, the International Energy Agency (IEA) Energy in Buildings and Community (EBC) Programme Annex 66 has established a scientific methodological framework for occupant behavior research, including data collection, behavior model representation, modeling and evaluation approaches, and the integration of behavior modeling tools with building performance simulation programs. Annex 66 also includes case studies and application guidelines to assist in building design, operation, and policymaking, using interdisciplinary approaches to reduce energy use in buildings and improve occupant comfort and productivity. This paper highlights the key research issues, methods, and outcomes pertaining to Annex 66, and offers perspectives on future research needs to integrate occupant behavior with the building life cycle.
Published: 2017

147. Coupling between the Alfvén eigenmode and edge-coherent mode on the experimental advanced superconducting tokamak

Author: Wang, M Y, primary, Liu, A D, additional, Zhou, C, additional, Zhuang, G, additional, Feng, X, additional, Zhang, J, additional, Zhong, X M, additional, Zhang, R B, additional, Wang, Y H, additional, Yang, J X, additional, Li, H, additional, Lan, T, additional, Xie, J L, additional, Liu, H Q, additional, Liu, Z X, additional, Mao, W Z, additional, Ding, W X, additional, and Liu, W D, additional
Published: 2024
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148. Detection of molecular recurrence in early-stage bladder cancer patients using a urinary tumor DNA assay after TransUrethral Resection of Bladder Tumor (TURBT)

Author: Zhang, R., primary, Hao, R., additional, Jingyu, Z., additional, Di, J., additional, Lei, Q., additional, Feng, X., additional, Cancan, J., additional, Yue, Z., additional, Xiaogang, Z., additional, Du, P., additional, Shidong, J., additional, Guanglei, C., additional, and Haige, C., additional
Published: 2024
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149. Effects of soyhulls with different particle size on the growth performance, blood indices and gut microbiota of yellow feather broilers

Author: Chen, X., primary, Luo, C., additional, Liu, Y., additional, Li, T., additional, Zhang, H., additional, and Feng, X., additional
Published: 2024
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150. Comparing novel electrophysiological biomarkers and circulating cardiac biomarkers in predicting cardiovascular mortality and all-cause mortality in the Akershus Sleep Apnea (ASAP) epidemiological cohort

Author: Hrubos-Strøm, H., primary, Øverby, T.C., additional, Sigurdardottir, F., additional, Feng, X., additional, Nikkonen, S., additional, Korkalainen, H., additional, Leppanen, T., additional, Töyräs, J., additional, and Arnardottir, E.S., additional
Published: 2024
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