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Your search keyword '"Fellous, M."' showing total 712 results
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712 results on '"Fellous, M."'

130. SRY protein is expressed in ovotestis and streak gonads from human sex-reversal.

Author

Salas-Cortés, L., Jaubert, F., Nihoul-Feketé, C., Brauner, R., Rosemblatt, M., and Fellous, M.

Subjects
GONADS, MAMMALS, Y chromosome, SERTOLI cells, TURNER'S syndrome, INTERSEX people, GERM cells
Abstract

In mammals, a master gene located on the Y chromosome, the testis-determining gene SRY, controls sex determination. SRY protein is expressed in the genital ridge before testis determination, and in the testis it is expressed in Sertoli and germ cells. Completely sex-reversed patients are classified as either 46,XX males or 46,XY females. SRY mutations have been described in only 15% of patients with 46,XY complete or partial gonadal dysgenesis. However, although incomplete or partial sex-reversal affects 46,XX true hermaphrodites, 46,XY gonadal dysgenesis, and 46,XX/46,XY mosaicism, only 15% of the 46,XX true hermaphrodites analyzed have the SRY gene. Here, we demonstrate that the SRY protein is expressed in the tubules of streak gonads and rete testis, indicating that the SRY protein is normally expressed early during testis determination. Based on these results, we propose that some factors downstream from SRY may be mutated in these 46,XY sex-reversal patients. We have also analyzed SRY protein expression in the ovotestis from 46,XX true hermaphrodites and 46,XX/46,XY mosaicism, demonstrating SRY protein expression in both testicular and ovarian portions in these patients. This suggests that the SRY protein does not inhibit ovary development. These results confirm that other factors are needed for complete testis development, in particular, those downstream of the SRY protein. Copyright © 2001 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2000
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147. Reactivity of Human Lymphoid and Lymphoblastoid Cells with Peanut Agglutinin: Detection of a Blood Cell Subset which Lacks Detectable Membrane HLA.

Author

Ballet, J.-J., Fellous, M., Sharon, N., Reisner, Y., and Agrapart, M.

Subjects
LYMPHOID tissue, IMMUNE system, LYMPHATICS, LYMPHOBLASTOID cell lines, PEANUTS, AGGLUTININS
Abstract

The number of cells reacting with fluorescein-labelled peanut agglutinin varies widely among human lymphoid organs. By separation techniques, reactive cells from tonsils were characterized as E-negative, non-immunoglobulin-bearing lymphocytes. In peripheral blood, the lectin reacted with a small percentage of lymphoid and monocytoid cells which lacked HLA membrane determinants but expressed the β2-microglobulin antigens. The latter phenotype was also found on human lymphoblastoid cell lines. Lectin binding thus provides an effective means of characterizing these cell subsets. [ABSTRACT FROM AUTHOR]

Published
1980
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148. Receptors for IgM on Human Lymphoblastoid B and T Cell Lines.

Author

Preud'homme, J.L., Gonnot, M., Fellous, M., and Sellgmann, M.

Subjects
IMMUNOGLOBULIN M, IMMUNOGLOBULINS, LYMPHOBLASTOID cell lines, CELL lines, T cells, LYMPHOCYTES, IMMUNE system
Abstract

Receptors for the Fc of IgM were studied together with other lymphocyte markers on cells from nineteen human lymphoblastoid cell lines. Receptors for IgM were found on three of seven T lines and three of twelve B lines studied. Culture conditions needed for an optimal detection of the receptor were different for B and T lines. The presence of the receptor for IgM could not be correlated with that of any other membrane marker. [ABSTRACT FROM AUTHOR]

Published
1979
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149. The Study of Human la-Like Specificities Using Antibody Eluates from Human Lymphoblastoid Cell Lines.

Author

Kamoun, M., Fellous, M., Lepage, V., and Dausset, J.

Subjects
CELL culture, BLOOD plasma, HLA histocompatibility antigens, ANTIGENS, IMMUNITY, IMMUNOGLOBULINS
Abstract

Five sera from multiparous women were absorbed and eluted from the Daudi cell line devoid of HLA antigens. These eluates recognized a specificity, Ly-Li1, of the Ly-Li system. Further absorption of one eluate on Bjab or Raji cell line subdivided this specificity. Family studies showed that the five eluates from the Daudi cell line segregate into two distinct groups. [ABSTRACT FROM AUTHOR]

Published
1977
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