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1,043 results on '"Felder, Robin A."'

102. Organ specificity of the dopamine1 receptor/adenyl cyclase coupling defect in spontaneously hypertensive rats

Author

Felder, Robin A., Kinoshita, Shohei, Ohbu, Keiou, Mouradian, M. Maral, Sibley, David R., Monsma, Frederick J., Minowa, Takashi, Minowa, Mari T., Canessa, leonardo M., and Jose, Pedro A.

Subjects
Dopaminergic mechanisms -- Physiological aspects, Adenylate cyclase -- Physiological aspects, Hypertension -- Physiological aspects, Biological sciences
Abstract

The interaction between adenyl cyclase and dopamine1 receptors was studied in spontaneously hypertensive rats (SHR) and compared with normotensive controls. A defective dopamine1 receptor-G protein coupling mechanism in proximal convoluted tubules (PCT) of the SHR was identified. This defect was assumed to be exclusive to the PCT because it was not observed in the renal collecting duct or in the striatum.

Published
1993

103. Expression of dopamine D1A receptor gene in proximal tubule of rat kidneys

Author

Yamaguchi, Ikuyo, Jose,Pedro A., Mouradian, M. Maral, Canessa, Leonardo M., Monsma, Frederick J., Jr., Sibley, David R., Takeyasu, Kunio, and Felder, Robin A.

Subjects
Dopamine receptors -- Genetic aspects, Kidney tubules -- Genetic aspects, Biological sciences
Abstract

Reverse polymerase chain reaction was utilized to generate copiesof the DNA fragment coding for the dopamine receptor D1A isolated from proximalconvoluted tubules (PCT) isolated from rat kidneys. The fragment was characterized using restriction fragment analysis, Southern blotting and nucleotide sequencing. Further, hybridization analysis using a solution containing PCT RNA demonstrated an RNA species corresponding to the DNA D1A gene.

Published
1993

104. Nephron specificity of dopamine receptor-adenylyl cyclase defect in spontaneous hypertension

Author

Ohbu, Keizou and Felder, Robin A.

Subjects
Dopamine receptors -- Physiological aspects, Hypertension -- Causes of, Kidney tubules -- Physiological aspects, Biological sciences
Abstract

Radioligand-binding studies and agonist induction of dopaminergic responses in the cortical collecting tubule (CCT) were carried out in spontaneously hypertensive (SHR) and normotensive rats to determine if CCT is also responsible in sodium retention due to defective coupling between the DA1 dopamine receptor and adenyl cyclase (AC). Genetic studies were also undertakento the same effect. Results reveal that coupling between DA1 and AC is normal in the CCT of SHR. Further, genetic analysis reveal that the defect in the DA1-AC interaction in the proximal tubule is not caused by mutation of the third cytoplasmic loop of the receptor.

Published
1993

114. Tandem Requirement for Full Renal D1R and D5R Activity

Author

Rozyyev, Selim, primary, Crusan, Annabelle P., additional, Tiu, Andrew C., additional, Jurgens, Julie A., additional, Quion, Justin Michael B., additional, Asico, Laureano D., additional, Felder, Robin A., additional, and Villar, Van Anthony M., additional

Published
2019
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117. Tandem Requirement for Renal D 1 R and D 5 R Functionality

Author

Rozyyev, Selim, primary, Crusan, Annabelle P, additional, Tiu, Andrew C, additional, Jurgens, Julie A, additional, Quion, Justin Michael B, additional, Asico, Laureano D, additional, Felder, Robin A, additional, Jose, Pedro A, additional, and Villar, Van Anthony M, additional

Published
2019
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118. Reading the future: the increased relevance of laboratory medicine in the next century

Author

Felder, Robin A., Graves, Seam, and Mifflin, Theodore

Subjects
Twenty-first century -- Forecasts and trends, Medical laboratories -- Forecasts and trends, Medical technology -- Forecasts and trends, Health care industry -- French Guiana
Abstract

Three clear trends have emerged in the field of clinical diagnostics. These are the development of laboratory automation systems, miniaturization and the commercialization of biotechnology. Other important trends that are likely to reshape the role of the clinical laboratory in the next century are the increased use of process control and data management, the development of advanced biometrics systems and the use of convenient, Web-based home health systems., With the countdown to the next millennium running out, it's only natural to look for deeper meaning in this chronological changeover. Using experience rather than tarot cards, these authors examine [...]

Published
1999

123. Automation of diagnostic testing

Author

Felder, Robin A. and Kost, Gerald J.

Subjects
Diagnostic services -- Technology application, Medical laboratories -- Technology application
Abstract

Modular stepwise automation is an ideal approach to automate small medical laboratories that cannot afford the total laboratory automation systems used by better funded commercial laboratories and regional laboratory networks. Modular systems are less expensive because they require a lesser degree of customization than large systems and can therefore be marketed pre-configured for the small laboratory., Laboratory Automation, while just in its infancy, now is considered essential by most clinical laboratories. Total laboratory automation systems automate all five steps in the test process, including preprocessing (sample [...]

Published
1998

131. Prospective evaluation of maternal serum human chorionic gonadotropin levels in 3428 pregnancies

Author

Bogart, Mark H., Jones, O.W., Felder, Robin A., Best, Robert G., Bradley, Linda, Butts, William, Crandall, Barbara, MacMahon, Wendy, Wians, Frank H., Jr., and Loeh, Paulette V.

Subjects
Human chromosome abnormalities -- Risk factors, Down syndrome -- Diagnosis, Fetus -- Abnormalities, Chorionic gonadotropin -- Measurement, Alpha fetoproteins -- Measurement, Health
Abstract

Pregnant women who are 35 years old or older are normally screened for fetal Down syndrome and other aneuploidy (chromosomal abnormalities). More recently, maternal blood levels of alpha-fetoprotein (AFP) have been considered, as well as age, as a risk factor for chromosomal disorders; however, these factors yield a detection rate of under 40 percent. Other studies have found an association between high levels of human chorionic gonadotropin (hCG), a hormone made by the implanted embryo and detected by pregnancy tests, and Down syndrome. Because this association has not been rigorously studied, data on these and other factors were collected from 3,428 pregnancies that were being screened for other defects. Of these, 255 pregnancies did not have normal outcomes, ranging from fetal death or distress to prematurity, twins, aneuploidy, and other abnormal outcomes. Of these 255 cases, 58 women did not have elevated hCG levels and 26 women did not have elevated AFP levels. Elevations in hCG levels, determined as multiples of the average level, when adjusted for weight, were higher in blacks and Orientals than in whites. Weight-adjusted average hCG levels for twin pregnancies with normal outcomes were also higher. Six of 11 pregnancies with aneuploidy had higher hCG levels, including four of six with Down syndrome. Of white women with normal outcomes, 10 percent had hCG levels more than double the average. Levels of hCG did not correlate with maternal age. The study indicates that adjustment of hCG levels for race and weight is important before they can be used to assess risk of Down syndrome. Further study to establish baseline levels is needed. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

142. Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells

Author

Gildea, John J., primary, Xu, Peng, additional, Kemp, Brandon A., additional, Carlson, Julia M., additional, Tran, Hanh T., additional, Bigler Wang, Dora, additional, Langouët-Astrié, Christophe J., additional, McGrath, Helen E., additional, Carey, Robert M., additional, Jose, Pedro A., additional, and Felder, Robin A., additional

Published
2018
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