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622 results on '"Faure, Christophe"'

107. Development of the Brussels Infant and Toddler Stool Scale (‘BITSS’): protocol of the study

Author

Vandenplas, Yvan, primary, Szajewska, Hania, additional, Benninga, Marc, additional, Di Lorenzo, Carlo, additional, Dupont, Christophe, additional, Faure, Christophe, additional, Miqdadi, Mohamed, additional, Osatakul, Seksit, additional, Ribes-Konickx, Carmen, additional, Saps, Miguel, additional, Shamir, Raanan, additional, and Staiano, Annamaria, additional

Published
2017
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109. Prevalence and Predictive Factors of Histopathological Complications in Children with Esophageal Atresia.

Author

Petit, Laetitia-Marie, Righini-Grunder, Franziska, Ezri, Jessica, Jantchou, Prevost, Aspirot, Ann, Soglio, Dorothée Dal, and Faure, Christophe

Subjects
ESOPHAGEAL atresia, H2 receptor antagonists, EOSINOPHILIC esophagitis, REGRESSION analysis, CHI-squared test, URETHROPLASTY, TRACHEAL fistula, DISEASE progression, DIGESTIVE system endoscopic surgery, SURGICAL complications, PROTON pump inhibitors, BARRETT'S esophagus, LANSOPRAZOLE, ESOPHAGUS diseases, PROPORTIONAL hazards models, LONGITUDINAL method, DISEASE complications
Abstract

Objectives:  Endoscopic follow-up after esophageal atresia (EA) tracheoesophageal fistula (TEF) repair is recommended to detect esophageal histopathological complications. We investigated the prevalence of histopathologically proven esophageal complications (peptic esophagitis, gastric metaplasia, and eosinophilic esophagitis) and assessed the predictors of these complications in children with EA-TEF.Materials and Methods:  This is a prospective longitudinal cohort study performed between September 2005 and December 2014 comprising 77 children with EA-TEF followed-up until February 2017. Univariate analysis was performed using the Wilcoxon's rank-sum test for continuous variables and the Pearson's chi-square test for categorical variables. Multivariable analysis was performed using a Cox regression hazard model. The association between clinical factors and histopathologically proven complications was estimated using a Cox regression hazard model with time until the appearance of complications as the time scale.Results:  All 77 children received proton pump inhibitors (PPIs) (n = 73) or H2 receptor antagonists (H2RA). A total of 252 endoscopies were performed in 73 children (median 2.6/child, range: 1-29). Median age at study completion was 4.9 years (range: 2.3-11.5 years). Histopathologically proven complications occurred in 38 children (52%): peptic esophagitis (n = 32, 44%), eosinophilic esophagitis (n = 15, 21%), and gastric metaplasia (n = 9, 12%). A total of 82% patients were on PPI or H2RA at the time of diagnosis of histological complication. Multivariable Cox regression analysis showed that patients with recurrent anastomotic strictures (>3 dilations) had a higher risk of occurrence of histopathologically proven complications over time (hazard ratio: 3.11, 95% confidence interval [CI]: 1.53-6.34). On univariate analysis, the result of the first endoscopy was not associated with the occurrence of histopathologically proven complications (odds ratio: 0.8, 95% CI: 0.16-3.95).Conclusion:  Histopathologically proven complications with potential long-term consequences occurred in approximately 50% of children after EA-TEF repair. A history of recurrent anastomotic strictures is associated with the occurrence of these complications. The result of the first endoscopy does not predict the histopathological outcome. Children with EA-TEF warrant close and systematic long-term follow-up at specialized multidisciplinary clinics with endoscopic evaluation. [ABSTRACT FROM AUTHOR]

Published
2019
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110. Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia.

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Schneider, Anne, Gottrand, Frédéric, Bellaiche, Marc, Becmeur, François, Lachaux, Alain, Bridoux-Henno, Laure, Michel, Jean-Luc, Faure, Christophe, Philippe, Paul, Vandenplas, Yvan, Dupont, Claire, Breton, Anne, Gaudin, Jean, Lamireau, Thierry, Muyshont, Laurence, Podevin, Guillaume, Viola, Sheila, Bertrand, Valérie, Caldari, Dominique, Colinet, Stéphanie, Wanty, Catherine, Sauleau, Erik, Leteurtre, Emmanuelle, Michaud, Laurent, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Schneider, Anne, Gottrand, Frédéric, Bellaiche, Marc, Becmeur, François, Lachaux, Alain, Bridoux-Henno, Laure, Michel, Jean-Luc, Faure, Christophe, Philippe, Paul, Vandenplas, Yvan, Dupont, Claire, Breton, Anne, Gaudin, Jean, Lamireau, Thierry, Muyshont, Laurence, Podevin, Guillaume, Viola, Sheila, Bertrand, Valérie, Caldari, Dominique, Colinet, Stéphanie, Wanty, Catherine, Sauleau, Erik, Leteurtre, Emmanuelle, and Michaud, Laurent

Abstract

To study the prevalence of Barrett esophagus (BE) (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia (EA). SUMMARY OF BACKGROUND DATA: EA patients are at high risk of BE. METHODS: This multicenter prospective study included EA patients aged 15 to 19 years. All eligible patients were proposed an upper endoscopy with multistaged esophageal biopsies under general anesthesia. Histological suspicion of metaplasia was confirmed centrally. RESULTS: One hundred twenty patients [mean age, 16.5 years (±1.4)] were included; 70% had been treated for gastroesophageal reflux disease (GERD) during infancy. At evaluation, 8% were undernourished, 41% had received antireflux surgery, and 41% presented with GERD symptoms, although only 28% were receiving medical treatment. Esophagitis was found at endoscopy in 34% and confirmed at histology in 67%. BE was suspected after endoscopy in 37% and was confirmed by histology for 43% of patients (50 gastric and 1 intestinal metaplasia). No endoscopic or histological anomalies were found at the anastomosis site. BE was not significantly related to clinical symptoms. In multivariate analysis, BE was associated with EA without fistula (P = 0.03), previous multiple antireflux surgery (P = 0.04), esophageal dilation (P = 0.04), suspicion of BE at endoscopy (P < 0.001), and histological esophagitis (P = 0.02). CONCLUSIONS: Patients with EA are at high risk of persistent GERD and BE. The development of BE is related to GERD history. Long-term systematic follow-up of the esophageal mucosa including multistaged biopsies is required, even in asymptomatic patients.

Published
2016

111. Prevalence of barrett esophagus in adolescents and young adults with esophageal atresia

Author

Schneider, Anne, Vandenplas, Yvan, Dupont, Claire, Breton, Anne, Gaudin, Jean, Lamireau, Thierry, Muyshont, Laurence, Podevin, Guillaume, Viola, Sheila, Bertrand, Valérie, Caldari, Dominique, Gottrand, Frederic, Colinet, Stéphanie, Wanty, Catherine, Sauleau, Erik, Leteurtre, Emmanuelle, Michaud, Laurent, Bellaiche, Marc, Becmeur, Francois, Lachaux, Alain, Bridoux-Henno, Laure, Michel, Jean-Luc, Faure, Christophe, Philippe, Paul, Schneider, Anne, Vandenplas, Yvan, Dupont, Claire, Breton, Anne, Gaudin, Jean, Lamireau, Thierry, Muyshont, Laurence, Podevin, Guillaume, Viola, Sheila, Bertrand, Valérie, Caldari, Dominique, Gottrand, Frederic, Colinet, Stéphanie, Wanty, Catherine, Sauleau, Erik, Leteurtre, Emmanuelle, Michaud, Laurent, Bellaiche, Marc, Becmeur, Francois, Lachaux, Alain, Bridoux-Henno, Laure, Michel, Jean-Luc, Faure, Christophe, and Philippe, Paul

Abstract

Objective: To study the prevalence of Barrett esophagus (BE) (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia (EA). Summary of Background Data: EA patients are at high risk of BE. Methods: This multicenter prospective study included EA patients aged 15 to 19 years. All eligible patients were proposed an upper endoscopy with multistaged esophageal biopsies under general anesthesia. Histological suspicion of metaplasia was confirmed centrally. Results: One hundred twenty patients [mean age, 16.5 years (1.4)] were included; 70% had been treated for gastroesophageal reflux disease (GERD) during infancy. At evaluation, 8% were undernourished, 41% had received antireflux surgery, and 41% presented with GERD symptoms, although only 28% were receiving medical treatment. Esophagitis was found at endoscopy in 34% and confirmed at histology in 67%. BE was suspected after endoscopy in 37% and was confirmed by histology for 43% of patients (50 gastric and 1 intestinal metaplasia). No endoscopic or histological anomalies were found at the anastomosis site. BE was not significantly related to clinical symptoms. In multivariate analysis, BE was associated with EA without fistula (P=0.03), previous multiple antireflux surgery (P=0.04), esophageal dilation (P=0.04), suspicion of BE at endoscopy (P<0.001), and histological esophagitis (P=0.02). Conclusions: Patients with EA are at high risk of persistent GERD and BE. The development of BE is related to GERD history. Long-term systematic follow-up of the esophageal mucosa including multistaged biopsies is required, even in asymptomatic patients. (NCT02495051)., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

112. Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia

Author

Schneider, Anne, primary, Gottrand, Frédéric, additional, Bellaiche, Marc, additional, Becmeur, François, additional, Lachaux, Alain, additional, Bridoux-Henno, Laure, additional, Michel, Jean-Luc, additional, Faure, Christophe, additional, Philippe, Paul, additional, Vandenplas, Yvan, additional, Dupont, Claire, additional, Breton, Anne, additional, Gaudin, Jean, additional, Lamireau, Thierry, additional, Muyshont, Laurence, additional, Podevin, Guillaume, additional, Viola, Sheila, additional, Bertrand, Valérie, additional, Caldari, Dominique, additional, Colinet, Stéphanie, additional, Wanty, Catherine, additional, Sauleau, Erik, additional, Leteurtre, Emmanuelle, additional, and Michaud, Laurent, additional

Published
2016
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116. Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate?

Author

Liu, Hai Lun, primary, Garzoni, Luca, additional, Herry, Christophe, additional, Durosier, Lucien Daniel, additional, Cao, Mingju, additional, Burns, Patrick, additional, Fecteau, Gilles, additional, Desrochers, André, additional, Patey, Natalie, additional, Seely, Andrew J. E., additional, Faure, Christophe, additional, and Frasch, Martin G., additional

Published
2016
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117. Role of Antidiarrhoeal Drugs as Adjunctive Therapies for Acute Diarrhoea in Children

Author

Faure, Christophe

Subjects
Article Subject
Abstract

Acute diarrhoea is a leading cause of child mortality in developing countries. Principal pathogens include Escherichia coli, rotaviruses, and noroviruses. 90% of diarrhoeal deaths are attributable to inadequate sanitation. Acute diarrhoea is the second leading cause of overall childhood mortality and accounts for 18% of deaths among children under five. In 2004 an estimated 1.5 million children died from diarrhoea, with 80% of deaths occurring before the age of two. Treatment goals are to prevent dehydration and nutritional damage and to reduce duration and severity of diarrhoeal episodes. The recommended therapeutic regimen is to provide oral rehydration solutions (ORS) and to continue feeding. Although ORS effectively mitigates dehydration, it has no effect on the duration, severity, or frequency of diarrhoeal episodes. Adjuvant therapy with micronutrients, probiotics, or antidiarrhoeal agents may thus be useful. The WHO recommends the use of zinc tablets in association with ORS. The ESPGHAN/ESPID treatment guidelines consider the use of racecadotril, diosmectite, or probiotics as possible adjunctive therapy to ORS. Only racecadotril and diosmectite reduce stool output, but no treatment has yet been shown to reduce hospitalisation rate or mortality. Appropriate management with validated treatments may help reduce the health and economic burden of acute diarrhoea in children worldwide.

Published
2013
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122. Sa2006 DNA Methylation in the Intestine and Peripheral Blood Reveal Distinct Associations With Crohn's Disease in Children

Author

Dupont-Lucas, Claire, primary, Samarani, Suzanne, additional, Deslandres, Colette, additional, Koestler, Devin, additional, Grandjean-Blanchet, Charlotte, additional, Mack, David R., additional, Faure, Christophe, additional, Jantchou, Prévost, additional, Marcil, Valerie, additional, Sagala, Patrick, additional, Duchatellier, Carl-Frederic, additional, Seidman, Ernest G., additional, Ahmad, Ali, additional, and Amre, Devendra K., additional

Published
2015
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131. Association Between the PTPN2 Gene and Crohnʼs Disease

Author

Marcil, Valerie, primary, Mack, David R., additional, Kumar, Vijay, additional, Faure, Christophe, additional, Carlson, Christopher S., additional, Beaulieu, Patrick, additional, Israel, David, additional, Krupoves, Alfreda, additional, Costea, Irina, additional, Lambrette, Philippe, additional, Grimard, Guy, additional, Dong, Jinsong, additional, Seidman, Ernest G., additional, Amre, Devendra K., additional, and Levy, Emile, additional

Published
2013
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137. Esophageal Impedance Monitoring for Gastroesophageal Reflux

Author

Mousa, Hayat M, primary, Rosen, Rachel, additional, Woodley, Frederick W, additional, Orsi, Marina, additional, Armas, Daneila, additional, Faure, Christophe, additional, Fortunato, John, additional, O'Connor, Judith, additional, Skaggs, Beth, additional, and Nurko, Samuel, additional

Published
2011
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146. Current pediatric indications for cisapride: A position paper by a panel convened by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition

Author

Vandenplas, Yvan, Belli, Dominique, Badriul, Hegar, Branski, David, Cadranel, Samy, Cervetto, J.L., Cleghorn, Geoffrey John G., Cucchiara, Salvatore, Davidson, Geoffrey Paul, Dias, Jorge Amil, Dupont, Christophe, Faure, Christophe, Firmansyah, Agus, Gottrand, Fréderique, Hassall, Eric, Heymans, Hugo Sa, Quak, Seng Hock, Jasinski, Christopher, Kneepkens, Frank, Koletzko, Sibylle, Kostovski, Aco, Leung, Y.K., Markiewicz, M., Maherzi, Abed, Ramirez-Mayans, Jaime Alfonso J., Milla, Peter P.J., Nurko, Samuel, Olafsdottir, Edda, Orsi, María Clelia M., Rodrigues Silva, Luciana, Poets, K., Polanco, Isabel Allué, Seo, Jeong Jea, Spolidoro, José, Saelzer, E., Staiano, Annamaria Maria, Szajewska, Hania, Vandenplas, Yvan, Belli, Dominique, Badriul, Hegar, Branski, David, Cadranel, Samy, Cervetto, J.L., Cleghorn, Geoffrey John G., Cucchiara, Salvatore, Davidson, Geoffrey Paul, Dias, Jorge Amil, Dupont, Christophe, Faure, Christophe, Firmansyah, Agus, Gottrand, Fréderique, Hassall, Eric, Heymans, Hugo Sa, Quak, Seng Hock, Jasinski, Christopher, Kneepkens, Frank, Koletzko, Sibylle, Kostovski, Aco, Leung, Y.K., Markiewicz, M., Maherzi, Abed, Ramirez-Mayans, Jaime Alfonso J., Milla, Peter P.J., Nurko, Samuel, Olafsdottir, Edda, Orsi, María Clelia M., Rodrigues Silva, Luciana, Poets, K., Polanco, Isabel Allué, Seo, Jeong Jea, Spolidoro, José, Saelzer, E., Staiano, Annamaria Maria, and Szajewska, Hania

Abstract

SCOPUS: re.j, info:eu-repo/semantics/published

Published
2000

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