101. MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma.
- Author
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Xiong J, Wu Y, Chen D, Zhang Z, Liu Y, Luo J, and Xu H
- Subjects
- Humans, Male, Female, Middle Aged, Risk Factors, Aged, Fatty Liver complications, Fatty Liver epidemiology, Adult, Logistic Models, Case-Control Studies, Waist Circumference, Colorectal Neoplasms etiology, Colorectal Neoplasms epidemiology, Adenoma epidemiology, Obesity, Abdominal complications, Obesity, Abdominal epidemiology
- Abstract
Objective: To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma., Methods: A total of 1395 subjects were enrolled and divided into a colorectal adenoma group (593 subjects) and a control group (802 subjects) according to the inclusion and exclusion criteria. The characteristics of patients in the colorectal adenoma group and the control group were compared by the chi-square test. Univariate and multivariate logistic analyses were used to analyze independent risk factors and associations with different MAFLD subtypes. Colorectal adenoma characteristics and the proportion of patients with high-risk colorectal adenoma were also compared., Results: High-density lipoprotein (HDL-C) was significantly lower in patients in the colorectal adenoma group than in those in the control group (P < 0.001). Logistic regression analysis revealed that age, obesity status, central obesity status, hypertension status, diabetes status, fatty liver status, smoking history, BMI, waist circumference, triglyceride level, HDL-C level, fasting blood glucose level and degree of hepatic steatosis were all independent risk factors for colorectal adenoma. Notably, MAFLD was associated with a significantly increased risk of colorectal adenoma in patients with central obesity (P < 0.001). In addition, obesity, central obesity, diabetes, fatty liver and degree of hepatic steatosis were all shown to be independent risk factors for high-risk colorectal adenoma. In addition, a greater proportion of MAFLD patients with central obesity than those without central obesity had high-risk colorectal adenoma., Conclusion: MAFLD and central obesity are independently associated with the development of colorectal adenoma. MAFLD with central obesity is associated with an increased risk of colorectal adenoma and high-risk adenoma., (© 2024. The Author(s).)
- Published
- 2024
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