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Svrha ovog priručnika je senzibiliziranje ravnatelja odgojno-obrazovnih institucija i nositelja obrazovnih politika u našoj zemlji na važnost mentalnoga zdravlja djece i učenika, posebice u kontekstu odgoja i obrazovanja, te uloge dječjih vrtića, osnovnih i srednjih škola. Sadržajno obuhvaća suvremene teorijske spoznaje te praktične implikacije za odgojno- obrazovni kontekst u okviru osnaživanja mentalnoga zdravlja djece, učenika i odgojno- obrazovnih djelatnika. Pritom, također obuhvaća tri važna područja: područje socijalno- emocionalnih kompetencija, otpornosti i mentalnoga zdravlja.

A qualidade de vida (QV) manifesta-se, precocemente, em domínios fundamentais da vida (família, escola e grupo de pares) e na relação com variáveis sociodemográficas. Atualmente, as restrições no contacto com estes grupos, particularmente na infância e adolescência, exaltam a importância de estratégias promotoras da QV nos mais jovens. Caracterizou-se a QV de crianças e jovens, explorando a relevância da escola, família e grupo de pares, num estudo quantitativo não experimental, com 605 participantes (69.4% crianças, 8-12 anos e 30.6% jovens, 13-17 anos), maioritariamente do interior do país (77%), 56.8% femininos e 57.2% do meio rural. Utilizou-se um questionário sociodemográfico e o Kid-Kindl para avaliação das dimensões escola, família e pares, da QV. As crianças apresentaram melhores resultados em todas as dimensões e no total da QV (QVg), exceto na subescala família. Esta última destacou-se nas crianças femininas, enquanto a escola se mostrou negativamente associada à idade (rs=-.144, p=.023). As crianças do meio rural e agregados familiares numerosos superiorizaram-se na QVg e subescala de bem-estar emocional. O género diferenciou favoravelmente os jovens masculinos no bem-estar emocional. A idade e o meio não foram relevantes neste grupo, mas a adoção de um estilo de vida saudável associou-se positivamente ao bem-estar emocional e QVg. O regresso a estilos de vida marcados pela ruralidade e em família alargada parece constituir-se promissor no âmbito da QV, sobretudo dos mais novos, incluindo as relações com os pares. Numa altura em que o recurso às interações baseadas nas tecnologias se agravou pela pandemia COVID-19, intensifica-se o desafio. The quality of life (QoL) manifests itself, early, in fundamental domains of life (family, school and peer group) and in the relationship with sociodemographic variables. Currently, restrictions on contact with these groups, particularly in childhood and adolescence, highlight the importance of strategies that promote QoL in younger people. The QoL of children and young people was characterized, exploring the relevance of school, family, and peer group, in a non-experimental quantitative study, with 605 participants (69.4% children, 8-12 years and 30.6% young people, 13- 17 years), mostly from the inland of the country (77%), 56.8% female and 57.2% from rural areas. A sociodemographic questionnaire and the Kid-Kindl were used to assess the school, family and friends’ dimensions of QoL. Children showed better results in all dimensions and in global QoL (QoLg), except for the family subscale. The latter stood out among female children, while school was negatively associated with age (rs=-.144, p=.023). Children from rural areas and numerous households had superior QoLg and emotional well-being. Gender differentiated boys in emotional well-being subscale. Age and residence area were not relevant in this group, but adopting a healthy lifestyle was positively associated with emotional well-being and QoLg. The return to lifestyles marked by rurality and in the extended family seems to be promising in terms of QoL, especially for the younger ones, including in relationships with peers. At a time when the use of technologybased interactions has been increased by the COVID-19 pandemic, the challenge is higher. info:eu-repo/semantics/publishedVersion

Submitted by Biblioteca Central (biblioteca@unicap.br) on 2021-03-16T13:20:14Z No. of bitstreams: 2 Ok_ana_maria_paixao_felix.pdf: 536166 bytes, checksum: 4eece690e8c4a5d579988a028a46f725 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2021-03-16T13:20:14Z (GMT). No. of bitstreams: 2 Ok_ana_maria_paixao_felix.pdf: 536166 bytes, checksum: 4eece690e8c4a5d579988a028a46f725 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2021-10-07 Motor stereotypes occur in a multitude of cases, although they are often associated with Autistic Spectrum Disorder (ASD). These stereotypes are commonly manifested in other specificities, such as in the case of people with visual impairment, senility, but there are still few Brazilian studies that deal with this subject in its diversity. We have as general objective to investigate the conception of motor stereotypes in the area of knowledge of the Health Sciences of CNPq, for this, we carry out a study of documentary character and bibliographic nature through a survey of scientific articles, dissertations and theses, in the databases: Scielo, Bireme, Google Scholar using the descriptors: (i) motor stereotypes; (ii) motor stereotypes and language; (iii) motor stereotypes, language and symptoms. We gave preference to articles published nationwide, as well as to works published from 2015 to 2019. In almost all of them, the results shown in the areas of Health Sciences were that, in the works consulted, motor stereotypes are seen as decontextualized repetitive movements, and considered as a symptom, with few allusions to language. It was also found that the medical field has the highest concentration of work on stereotypes and that its conception as a symptom prevails mainly linked to autism. To a lesser extent, the relationship between stereotypes as symptoms or behaviors was verified in other instances, such as dementia and Rett Syndrome. As estereotipias motoras acontecem em uma infinidade de casos, embora sejam frequentemente associadas ao Transtorno do Espectro Autista (TEA). Essas estereotipias são comumente manifestadas em outras especificidades como nos casos de pessoas com deficiência visual, senilidade, porém existem ainda, poucas pesquisas brasileiras que versem sobre esse assunto em sua diversidade. Temos como objetivo geral investigar a concepção das estereotipias motoras na área do conhecimento das Ciências da Saúde do CNPq, para isso, realizamos um estudo de caráter documental e de natureza bibliográfica através de um levantamento de artigos científicos, dissertações e teses, nas bases de dados: Scielo, Bireme, Google Acadêmico usando os descritores: (i) estereotipias motoras; (ii) estereotipias motoras e linguagem; (iii) estereotipias motoras, linguagem e sintomas. Demos preferência a artigos publicados em âmbito nacional, assim como, a trabalhos publicados a partir do ano de 2015 até 2019. Em quase sua totalidade, os resultados mostrados nas áreas das Ciências da Saúde, foram que, nos trabalhos consultados, as estereotipias motoras são vistas como movimentos repetitivos descontextualizados, e consideradas como sintoma, com poucas alusões à linguagem. Verificou-se também, que a área médica apresenta a maior concentração de trabalhos sobre estereotipias e que a concepção dela enquanto sintoma prevalece ligada principalmente ao autismo. Em menor quantidade, verificou-se a relação das estereotipias como sintomas ou comportamentos em outras instâncias como em demências e na Síndrome de Rett.

Additional file1 Fig S1. Violin plots comparing the distribution of the quantification values by gene, amplicon size and storage time including all samples. For each period of time, median values of copies/µL (depicted as Log10) per amplicon either between host and virus or for the two different amplicons within host and within viruses are compared by means of a Wilcoxon Mann–Whitney test. For each comparison, p-values for the null-hypothesis of non-different median values between the corresponding distributions are indicated. Fragments are represented as follows: “Human short” to represent 65 bp tubulin-β gene amplicon; “Human long” to represent 149 bp tubulin-β gene amplicon; “Viral short” to represent 69 bp L1 gene amplicon and “Viral long” to represent 134 bp L1 gene amplicon. Each period of time is represented below fragments.

Background Quality of the nucleic acids extracted from Formalin Fixed Paraffin Embedded (FFPE) samples largely depends on pre-analytic, fixation and storage conditions. We assessed the differential sensitivity of viral and human double stranded DNA (dsDNA) to degradation with storage time. Methods We randomly selected forty-four HPV16-positive invasive cervical cancer (ICC) FFPE samples collected between 1930 and 1935 and between 2000 and 2004. We evaluated through qPCR the amplification within the same sample of two targets of the HPV16 L1 gene (69 bp, 134 bp) compared with two targets of the human tubulin-β gene (65 bp, 149 bp). Results Both viral and human, short and long targets were amplified from all samples stored for 15 years. In samples archived for 85 years, we observed a significant decrease in the ability to amplify longer targets and this difference was larger in human than in viral DNA: longer fragments were nine times (CI 95% 2.6–35.2) less likely to be recovered from human DNA compared with 1.6 times (CI 95% 1.1–2.2) for viral DNA. Conclusions We conclude that human and viral DNA show a differential decay kinetics in FFPE samples. The faster degradation of human DNA should be considered when assessing viral DNA prevalence in long stored samples, as HPV DNA detection remains a key biomarker of viral-associated transformation.

Additional file 1. Supplementary figures.

Dissertação de Mestrado em Design eom a especialização em Design de Comunicação apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção grau de Mestre. O seguinte estudo enquadra-se no âmbito do Mestrado de Design de Comunicação, mais concretamente nas áreas da Ilustração e do Design Editorial, como meios de comunicação da temática da prevenção de riscos focada nos incêndios florestais e rurais. A escolha deste tema surge do facto de existir pouca informação sobre incêndios florestais e rurais no mercado nacional dedicados às crianças, tendo em conta que Portugal ocupa uma das posições mais elevadas no ranking de incêndios florestais da Europa. Este projecto centrou-se na criação de um suporte editorial de raiz: um livro destinado a crianças entre os sete e os dez anos, que contém informações pertinentes relativamente a prevenções e ações em caso de incêndios rurais e florestais. Para que as informações e a mensagem ética presentes fossem corretamente absorvidas, ponderadas e por fim apreendidas, procurou-se utilizar uma linguagem, não só a nível visual, mas também textual, de fácil compreensão e igualmente lúdica, com o intuito de motivar o público infantil. Assim, procedeu-se à criação de uma história, à sua ilustração e ao seu design e organização editorial. Recorreu-se a uma metodologia mista, numa primeira abordagem qualitativa não intervencionista, com seguimento de uma fase intervencionista. O resultado final deste estudo consistiu num objeto capaz de contribuir para o universo da ilustração para a infância e para a consciencialização e aprendizagem das temáticas abordadas. ABSTRACT: The following study and project was developed within the scope of the Master of Communication Design, specifically in the areas of Illustration and Editorial Design, as a means of communication on the theme of risk prevention focused on forest and rural fires. The choice of this theme arises from the fact that there is little information on forest and rural fires in the national market dedicated to children, taking into account that Portugal occupies one of the highest positions in the ranking of forest fires in Europe. This project focused on creating an editorial support from scratch: a book for children between seven and ten years old, which contains pertinent information regarding prevention and actions to take, in case of rural and forest fires. In order for this information and ethical message present be correctly absorbed, pondered and perceived, we tried to use a language, not only visually but also textual, easy to understand and equally playful, in order to motivate the infant audience. Therefore, a story was created, illustrated and designed, and organized in a picture book. A mixed methodology was used, first, a qualitative non-interventionist approach followed by an interventionist phase. The result of this study consist of an object capable of contributing to the universe of illustration for childhood and for the awareness and learning of the themes addressed. N/A

Mechanical cues induce a variety of downstream effects on cells, including the regulation of stem cell behavior. Cell fate is typically characterized on biomaterial substrates where mechanical and chemical properties can be precisely tuned; however, most of these substrates do not recapitulate the biological complexity of the extracellular matrix (ECM). Here, hydrogels are engineered for mechanobiological studies using two major components of the ECM: hyaluronic acid (HA) and fibronectin (FN). Rather than typical surface chemisorption of FN to substrates, the system contains full‐length FN covalently crosslinked to HA throughout the hydrogel. The control over the mechanical properties of the hydrogel independent of the concentration of FN and the ability to culture viable cells either on top or encapsulated within the hydrogels are shown. Interestingly, human mesenchymal stem cells (MSCs) experience an increase in nuclear translocation of the yes‐associated protein (YAP) to the nucleus when cultured on (2D) substrates with increasing amounts of FN while maintaining constant hydrogel stiffness. However, this FN dependence on nuclear YAP translocation is not observed for MSCs encapsulated in (3D) hydrogels. This work develops complex hydrogels that recapitulate features of the ECM for the control of stem cells in both 2D and 3D environments.