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1,308 results on '"Ertl-Wagner, Birgit"'

101. Sachverzeichnis

Author

Stäbler, Axel, additional, Ertl-Wagner, Birgit, additional, and Hartmann, Marius, additional

Published
2019
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102. 7 Orbita

Author

Stäbler, Axel, additional, Ertl-Wagner, Birgit, additional, and Hartmann, Marius, additional

Published
2019
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103. Vorwort

Author

Stäbler, Axel, additional, Ertl-Wagner, Birgit, additional, and Hartmann, Marius, additional

Published
2019
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105. 9 Halsregion

Author

Stäbler, Axel, additional, Ertl-Wagner, Birgit, additional, and Hartmann, Marius, additional

Published
2019
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111. Qualitätswerkzeuge

Author

Ertl-Wagner, Birgit, Steinbrucker, Sabine, Wagner, Bernd C., Ertl-Wagner, Birgit, Steinbrucker, Sabine, and Wagner, Bernd C.

Published
2013
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119. Überprüfungsmethoden

Author

Ertl-Wagner, Birgit, Steinbrucker, Sabine, Wagner, Bernd C., Ertl-Wagner, Birgit, Steinbrucker, Sabine, and Wagner, Bernd C.

Published
2013
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120. Fragen und Fakten

Author

Ertl-Wagner, Birgit, Steinbrucker, Sabine, Wagner, Bernd C., Ertl-Wagner, Birgit, Steinbrucker, Sabine, and Wagner, Bernd C.

Published
2013
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121. Radiomic Features Based on MRI Predict Progression-Free Survival in Pediatric Diffuse Midline Glioma/Diffuse Intrinsic Pontine Glioma

Author

Wagner, Matthias W, Namdar, Khashayar, Napoleone, Marc, Hainc, Nicolin, Amirabadi, Afsaneh, Fonseca, Adriana, Laughlin, Suzanne, Shroff, Manohar M, Bouffet, Eric, Hawkins, Cynthia, Khalvati, Farzad, Bartels, Ute, Ertl-Wagner, Birgit Bettina, University of Zurich, and Wagner, Matthias W

Subjects
10043 Clinic for Neuroradiology, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, Radiology, Nuclear Medicine and imaging, General Medicine, Radiology, Nuclear Medicine and imaging
Abstract

Purpose: Biopsy-based assessment of H3 K27 M status helps in predicting survival, but biopsy is usually limited to unusual presentations and clinical trials. We aimed to evaluate whether radiomics can serve as prognostic marker to stratify diffuse intrinsic pontine glioma (DIPG) subsets. Methods: In this retrospective study, diagnostic brain MRIs of children with DIPG were analyzed. Radiomic features were extracted from tumor segmentations and data were split into training/testing sets (80:20). A conditional survival forest model was applied to predict progression-free survival (PFS) using training data. The trained model was validated on the test data, and concordances were calculated for PFS. Experiments were repeated 100 times using randomized versions of the respective percentage of the training/test data. Results: A total of 89 patients were identified (48 females, 53.9%). Median age at time of diagnosis was 6.64 years (range: 1–16.9 years) and median PFS was 8 months (range: 1–84 months). Molecular data were available for 26 patients (29.2%) (1 wild type, 3 K27M-H3.1, 22 K27M-H3.3). Radiomic features of FLAIR and nonenhanced T1-weighted sequences were predictive of PFS. The best FLAIR radiomics model yielded a concordance of .87 [95% CI: .86–.88] at 4 months PFS. The best T1-weighted radiomics model yielded a concordance of .82 [95% CI: .8–.84] at 4 months PFS. The best combined FLAIR + T1-weighted radiomics model yielded a concordance of .74 [95% CI: .71–.77] at 3 months PFS. The predominant predictive radiomic feature matrix was gray-level size-zone. Conclusion: MRI-based radiomics may predict progression-free survival in pediatric diffuse midline glioma/diffuse intrinsic pontine glioma.

Published
2022

122. Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency

Author

Das, Anirban, primary, Tabori, Uri, additional, Sambira Nahum, Lauren C., additional, Collins, Natalie B., additional, Deyell, Rebecca, additional, Dvir, Rina, additional, Faure-Conter, Cecile, additional, Hassall, Timothy E., additional, Minturn, Jane E., additional, Edwards, Melissa, additional, Brookes, Elissa, additional, Bianchi, Vanessa, additional, Levine, Adrian, additional, Stone, Simone C., additional, Sudhaman, Sumedha, additional, Sanchez Ramirez, Santiago, additional, Ercan, Ayse B., additional, Stengs, Lucie, additional, Chung, Jill, additional, Negm, Logine, additional, Getz, Gad, additional, Maruvka, Yosef E., additional, Ertl-Wagner, Birgit, additional, Ohashi, Pamela S., additional, Pugh, Trevor, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, and Morgenstern, Daniel A., additional

Published
2023
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150. Vorwort

Author

Stäbler, Axel, additional and Ertl-Wagner, Birgit, additional

Published
2018
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