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1,015 results on '"Echeverría, Javier"'

109. Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects.

Author

Bagheri Bavandpouri, Faezeh Sadat, Azizi, Atefeh, Abbaszadeh, Fatemeh, Kiani, Amir, Farzaei, Mohammad Hosein, Mohammadi-Noori, Ehsan, Fakhri, Sajad, and Echeverría, Javier

Subjects
SPINAL cord injuries, MATRIX metalloproteinases, NEURALGIA, SPINAL cord, GLUTATHIONE
Abstract

Background: Considering the complex pathological mechanisms behind spinal cord injury (SCI) and the adverse effects of present non-approved drugs against SCI, new studies are needed to introduce novel multi-target active ingredients with higher efficacy and lower side effects. Polydatin (PLD) is a naturally occurring stilbenoid glucoside recognized for its antioxidative and anti-inflammatory properties. This study aimed to assess the effects of PLD on sensory-motor function following SCI in rats. Methods: Following laminectomy and clip compression injury at the thoracic 8 (T8)-T9 level of the spinal cord, rats were randomly assigned to five groups: Sham, SCI, and three groups receiving different doses of PLD treatment (1, 2, and 3 mg/kg). Over 4 weeks, behavioral tests were done such as von Frey, acetone drop, hot plate, Basso-Beattie-Bresnahan, and inclined plane test. At the end of the study, changes in catalase and glutathione activity, nitrite level, activity of matrix metalloproteinase 2 (MMP2) and MMP9 as well as spinal tissue remyelination/neurogenesis, were evaluated. Results: The results revealed that PLD treatment significantly improved the behavioral performance of the animals starting from the first week after SCI. Additionally, PLD increased catalase, and glutathione levels, and MMP2 activity while reduced serum nitrite levels and MMP9. These positive effects were accompanied by a reduction in the size of the lesion and preservation of neuronal count. Conclusion: In conclusion, PLD showed neuroprotective effects in SCI rats by employing anti-inflammatory and antioxidant effects, through which improve sensory and motor function. [ABSTRACT FROM AUTHOR]

Published
2024
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110. Exudate and Propolis from Escallonia pulverulenta : Phytochemical Characterization and Antibacterial Activity.

Author

Jorquera, Bairon, Valenzuela-Barra, Gabriela, Mayorga, Ailin, Mejía, Jessica, Núñez, Gabriel, Gómez, Miguel, Montenegro, Gloria, Vera Quezada, Waleska E., Echeverría, Javier, Costa de Camargo, Adriano, Lino von Poser, Gilsane, and Bridi, Raquel

Subjects
PROPOLIS, ENDEMIC species, STREPTOCOCCUS pyogenes, PHENOLIC acids, PHENOLS
Abstract

Propolis is a complex mixture formed from exudates that bees collect from plants and then mix with beeswax and their own salivary enzymes. Chilean propolis is characterized by the presence of phenolic compounds, which are considered responsible for the biological activities. The endemic species Escallonia pulverulenta (Ruiz and Pav.) Pers. [Escalloniaceae] is a recognized source of exudate to produce propolis. This study reports for the first time the chemical profile and antibacterial activity of E. pulverulenta exudate and leaves, as well as two samples of Chilean propolis. Palynological and morphological analysis showed the presence of E. pulverulenta as one of the main species in the propolis samples. UPLC-MS/MS analyses enabled the identification of phenolic acids in the leaves and in the propolis. Conversely, flavonoids are mainly present in exudates and propolis. Quercetin is the most abundant flavonol in the exudate, with similar concentrations in the propolis samples. Nevertheless, the main compound present in both samples of propolis was the flavanone pinocembrin. The antibacterial results obtained for exudate and propolis have shown a similar behavior, especially in the inhibition of Streptococcus pyogenes. These results show the importance of the exudates collected by the bees in the chemical composition and antibacterial capacity of propolis. [ABSTRACT FROM AUTHOR]

Published
2024
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112. The Philosophy of Technoworlds and Technopersons

Author

Echeverría, Javier, Vermaas, Pieter E., Editor-in-chief, Didier, Christelle, Series editor, Cressman, Darryl, Series editor, Doorn, Neelke, Series editor, Laspra, Belén, editor, and López Cerezo, José Antonio, editor

Published
2018
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121. Chara sp. Charophyceae

Author

Echeverría, Javier, Paniagua-Zambrana, Narel Y., Bussmann, Rainer W., Bussmann, Rainer W., Editor-in-Chief, and Paniagua-Zambrana, Narel Y., Editor-in-Chief

Published
2020
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128. Anthemis arvensis L. Asteraceae

Author

Echeverría, Javier, Paniagua-Zambrana, Narel Y., Bussmann, Rainer W., Bussmann, Rainer W., Editor-in-Chief, and Paniagua-Zambrana, Narel Y., Editor-in-Chief

Published
2020
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131. Oxychloe andina Phil. Juncaceae

Author

Echeverría, Javier, Paniagua-Zambrana, Narel Y., Bussmann, Rainer W., Bussmann, Rainer W., Editor-in-Chief, and Paniagua-Zambrana, Narel Y., Editor-in-Chief

Published
2020
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135. Nostoc sp. Nostocaceae

Author

Echeverría, Javier, Paniagua-Zambrana, Narel Y., Bussmann, Rainer W., Bussmann, Rainer W., Editor-in-Chief, and Paniagua-Zambrana, Narel Y., Editor-in-Chief

Published
2020
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