294 results on '"Early onset preeclampsia"'
Search Results
102. Evaluation of BRD4 levels in patients with early-onset preeclampsia
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Yasemin Dogan, Mustafa Behram, and Süleyman Cemil Oğlak
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Adult ,medicine.medical_specialty ,Cell Cycle Proteins ,Gastroenterology ,Preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Healthy control ,medicine ,Humans ,In patient ,Prospective Studies ,030219 obstetrics & reproductive medicine ,Proteinuria ,business.industry ,Early onset preeclampsia ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Blood pressure ,Reproductive Medicine ,Case-Control Studies ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Female ,medicine.symptom ,business ,Biomarkers ,Transcription Factors - Abstract
This study aimed to detect Bromodomain Containing Protein 4 (BRD4) concentrations in the serum of early-onset preeclamptic patients and compare them with the healthy control group.This prospective case-control study was performed from June 2019 to December 2019. Of the 80 pregnant patients included in the study, we enrolled 40 patients with early-onset preeclampsia as the study group, and 40 normotensive healthy gestational age- and gravidity-matched patients with normal blood pressure without proteinuria as the control group. Demographic characteristics, amount of proteinuria, and serum BRD4 concentrations were recorded.Maternal serum BRD4 concentrations were significantly higher in patients with preeclampsia (39.10 ± 42.14 ng/mL) compared to the participants in the control group (13.64 ± 7.24 ng/mL, p0.001). There was a positive intermediate correlation between serum BRD4 levels and the amount of proteinuria (r = 0.447, p = 0.006).Maternal serum BRD4 levels were significantly higher in preeclamptic patients compared to healthy pregnant women. Also, the amount of proteinuria was positively correlated with serum BRD4 levels. Although this preliminary study shows increased BRD4 levels in preeclampsia, its utility as a biomarker must be clarified.
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- 2021
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103. Screening for early-onset preeclampsia
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Howard Cuckle
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Pediatrics ,medicine.medical_specialty ,business.industry ,Early onset preeclampsia ,MEDLINE ,Obstetrics and Gynecology ,Pregnancy Trimester, First ,Text mining ,Pre-Eclampsia ,Pregnancy ,Humans ,Medicine ,Female ,business ,Placenta Growth Factor - Published
- 2021
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104. 641 Fetal growth restriction and risk of intrapartum cesarean among women with early onset preeclampsia
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Michelle R. Petrich, Emily N. Flagler, Emily A. Armstrong, Kara M. Rood, Maged M. Costantine, Erin M. Cleary, and Patricia K. Belle
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medicine.medical_specialty ,business.industry ,Obstetrics ,Early onset preeclampsia ,Fetal growth ,Obstetrics and Gynecology ,Medicine ,business - Published
- 2021
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105. Association between Val158Met COMT, TNF-α -857 C>T, TNFR1 36 A>G, IL-1α 4845 G>T and IL-10 -1082 A>G polymorphisms and risk of early-onset preeclampsia and its complications
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Jelena Lukic, Drina Topalov, Dragana Tomsevic, Nada Majkić-Singh, Ljiljana Mirkovic, Svetlana Ignjatović, and Tijana Krnjeta
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2. Zero hunger ,lcsh:R5-920 ,medicine.medical_specialty ,pre-eclampsia ,business.industry ,Early onset preeclampsia ,polymorphism, genetic ,comt protein, human ,cytokines ,3. Good health ,Interleukin 10 ,Endocrinology ,Internal medicine ,medicine ,Pharmacology (medical) ,lcsh:Medicine (General) ,business - Abstract
Background/Aim. Pre-eclampsia (PE) belongs to the group of hypertensive disorders in pregnancy with the global average incidence of 2.16%. It is considered as one of the leading causes of maternal and neonatal morbidity and mortality worldwide. The goal of this study was to assess the potential association between Val158Met catechol-o-methyltransferase (COMT), tumor necrosis factor-alpha (TNF-α) -857 C>T, tumor necrosis factor receptor 1 (TNFR1) 36 A>G, interleukin-1alpha (IL-1α) 4845 G>T and interleukin-10 (IL-10) -1082 A>G polymorphisms and risk of early-onset pre-eclampsia (PE) and its complications. Methods. The study included 47 early-onset PE patients, which were grouped by disease severity and by size for gestational age and 47 control cases. The Val158Met polymorphism was genotyped by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analysis and inflammatory cytokine polymorphisms by the Sanger sequencing method. Results. The COMT Met allele as well as IL-1α T showed a protective role, decreasing the risk of early-onset PE after age and body mass index (BMI) adjustments. The detected interactions between the COMT Met and IL-10 A alleles, as well as between the COMT Met and TNF-α T alleles were insignificant after age and BMI adjustments. Conclusion. COMT and IL-1α may be used as candidate genes for early-onset PE and its severe form and small for gestational age (SGA) complications.
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- 2017
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106. The two faces of preeclampsia
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Tamás P, Betlehem J, Szekeres-Barthó J, Kovács K, Wami GA, Vértes V, and Bódis J
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- Female, Humans, Infant, Newborn, Male, Placenta, Pregnancy, Proteinuria, Abruptio Placentae, Eclampsia, Hypertension, Pre-Eclampsia
- Abstract
During normal pregnancy, blood volume increases by nearly two liters. Distinctively, the absence and also the extreme extent regarding the volume expansion are likely accompanied with serious conditions. Undoubtedly, preeclampsia, defined as the appearance of hypertension and proteinuria during the second half of pregnancy, is not a homogenous disease. The early onset which begins prior to the 34th week, is characteristically a hypovolemia-associated form and depicts the placental origination, in which endothelial damage leads to hypertension and organ damage due to vasoconstriction and microthrombosis. Fetal blood supply progressively worsens due to placental insufficiency. The outcome of this condition often leads to fetal death, eclampsia, or placental abruption. Management is confined to a diligent prolongation of pregnancy to accomplish improved neonatal pulmonary function. The late onset form, associated with high cardiac output, is a maternal disease, in which obesity is a risk factor since it predisposes individuals to enhanced water retention, hypertension, and a weakened endothelial dysfunction. Initially, low extremity edema often times progresses to a generalized form and frequently results in hypertension. In several cases proteinuria appears. This condition entirely meets the preedampsia criteria. Fetal weight is normal or frequently over the average. It is very likely, the increasing parenchymal stasis will lead to ascites, eclampsia, or placental abruption. During the management of this hypervolemia-associated preedampsia, the administration of diuretic furosemide treatment seemingly offers promise.
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- 2022
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107. Differences in Mean Levels of Maternal Resistin Serum between Early Onset Preeclampsia (EOPE) and Late Onset Preeclampsia (LOPE)
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Yusrawati, P. Alfajra, and R. Machmud
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0301 basic medicine ,medicine.medical_specialty ,business.industry ,Early onset preeclampsia ,Obstetrics and Gynecology ,030209 endocrinology & metabolism ,Late onset preeclampsia ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Medicine ,Resistin ,business - Published
- 2016
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108. Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q
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Wei Long, Hongjuan Ding, Jingyun Li, Jun Li, Rong Shen, Xuejing Song, Can Rui, Li Meng, and Rui Zhang
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Adult ,0301 basic medicine ,medicine.medical_specialty ,Time Factors ,Reproductive medicine ,Apoptosis ,Transfection ,Cell Line ,Preeclampsia ,Andrology ,03 medical and health sciences ,lncRNA ,complement protein C1q ,Pre-Eclampsia ,Obstetrics and gynaecology ,Cell Movement ,Pregnancy ,Placenta ,medicine ,Humans ,reproductive and urinary physiology ,business.industry ,Complement C1q ,RPAIN ,Trophoblast ,medicine.disease ,early onset preeclampsia ,Long non-coding RNA ,Trophoblasts ,Complement system ,030104 developmental biology ,medicine.anatomical_structure ,Gene Expression Regulation ,Oncology ,Case-Control Studies ,embryonic structures ,Immunology ,Female ,RNA, Long Noncoding ,business ,Research Paper ,Signal Transduction - Abstract
// Xuejing Song 1, 2, * , Can Rui 1, * , Li Meng 3 , Rui Zhang 1 , Rong Shen 3 , Hongjuan Ding 1 , Jun Li 4 , Jingyun Li 4 , Wei Long 1 1 Department of Obstetrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China 2 Fourth Clinical Medicine College, Nanjing Medical University, Nanjing, China 3 Nanjing Maternity and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China 4 State key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China * These authors contributed equally to this work Correspondence to: Wei Long, email: wlong@njmu.edu.cn Jingyun Li, email: dagumahao@163.com Keywords: lncRNA, RPAIN, early onset preeclampsia, complement protein C1q Received: October 09, 2016 Accepted: December 01, 2016 Published: December 09, 2016 ABSTRACT Long non-coding RNAs (lncRNAs) are key regulatory molecules that are involved in a variety of biological processes and human diseases. Their impact on early onset preeclampsia remains unclear. In this study, we tested the expression of RPAIN (transcript variant 12 of RPA interacting protein, a non-coding RNA, NR_027683.1) in placenta tissues derived from 25 pregnant women with PE and 15 healthy pregnant women using quantitative real-time PCR. The effect of RPAIN on trophoblast proliferation, invasion, and apoptosis and the underlying mechanisms were examined in trophoblast cell lines (HTR-8/SVneo). The results showed that RPAIN expression levels were significantly increased in early onset preeclamptic placentas compared to normal controls. The proliferation and invasive abilities of the trophoblast cells were significantly inhibited, and the apoptosis abilities of the trophoblast cells were significantly promoted when RPAIN was overexpressed. In addition, the overexpression of RPAIN inhibited the expression of complement protein C1q. Furthermore, C1q overexpression rescued the decreased cell invasion and enhanced cell apoptosis in RPAIN-overexpressing trophoblast cells. Our results suggest that increased RPAIN levels may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1q. Therefore, we proposed RPAIN as a novel lncRNA molecule, which might contribute to the development of PE (preeclampsia) and might compose a potential diagnostic and therapeutic target for this disease.
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- 2016
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109. Aortic intima-media thickness in neonates exposed to early-onset preeclampsia
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Ageliki A. Karatza, Despoina Gkentzi, Nikoleta Oikonomou, Gabriel Dimitriou, and Sotirios Fouzas
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Adult ,Male ,medicine.medical_specialty ,Preeclampsia ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,medicine ,Humans ,Vascular Diseases ,Postnatal day ,Aorta ,reproductive and urinary physiology ,business.industry ,Early onset preeclampsia ,Infant, Newborn ,Obstetrics and Gynecology ,medicine.disease ,female genital diseases and pregnancy complications ,Aortic intima ,Echocardiography ,embryonic structures ,Pediatrics, Perinatology and Child Health ,cardiovascular system ,Cardiology ,Female ,Aortic diameter ,Tunica Intima ,Tunica Media ,business - Abstract
Aortic intima-media thickness (aIMT) and its ratio to aortic diameter (aIMT/AoD) were measured on the second and fifth postnatal day in 39 neonates exposed to early-onset preeclampsia and 39 controls. Both aIMT and aIMT/AoD were higher in neonates exposed to preeclampsia (P 0.001 for all comparisons).
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- 2020
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110. Pravastatin for Early-onset Preeclampsia: A Randomized, Blinded, Placebo-controlled Trial
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S. Ahmad, P. Hewett, Versha Cheed, David J. Williams, A.T. Vince, Jane P Daniels, Khalid S. Khan, K. Spencer, Keqing Wang, A. Ahmed, and Lee J Middleton
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medicine.medical_specialty ,business.industry ,Early onset preeclampsia ,Internal medicine ,Placebo-controlled study ,Medicine ,business ,Pravastatin ,medicine.drug - Published
- 2020
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111. The effect of early-onset preeclampsia on the intestinal blood flow of preterm infants
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Saskia Maria Wiegerinck Fekete, Ligia Maria Suppo de Souza Rugolo, José Eduardo Corrente, Simone Manso de Carvalho Pelicia, and Universidade Estadual Paulista (Unesp)
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Physiology ,Gestational Age ,030204 cardiovascular system & hematology ,Preeclampsia ,preterm infant ,preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Medicine ,Humans ,Prospective Studies ,skin and connective tissue diseases ,reproductive and urinary physiology ,Gastrointestinal tract ,030219 obstetrics & reproductive medicine ,business.industry ,Early onset preeclampsia ,Hemodynamics ,Infant, Newborn ,Obstetrics and Gynecology ,Infant ,Blood flow ,medicine.disease ,female genital diseases and pregnancy complications ,Doppler ultrasonography ,embryonic structures ,Pediatrics, Perinatology and Child Health ,Female ,sense organs ,gastrointestinal tract ,business ,Blood Flow Velocity ,Infant, Premature - Abstract
Made available in DSpace on 2020-12-12T02:28:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 Background: Preeclampsia is associated with important vascular maternal changes. However, its repercussions on newborns’ circulation have hardly been reported. Objective: To investigate whether early-onset preeclampsia is associated with altered blood flow of the superior mesenteric artery (SMA) in preterm infants. Materials and methods: Prospective study with 60 preterm infants of mothers with early-onset preeclampsia (PE) and 60 of normotensive mothers, paired according to the gestational age, from 2013 to 2016. Maternal, gestational, and neonatal clinical data were evaluated. The outcome of interest was the blood flow velocity in SMA, evaluated by the peak systolic velocity and end-diastolic velocity and by the resistance index and pulsatility index, through the Doppler ultrasound in the first 72 h of life. Covariance analysis was used to determine the PE effect on the SMA blood flow, controlling for possible confounding variables. Results: The mean gestational age was 30 weeks. Infants of mothers with PE had significantly lower values of peak systolic and end-diastolic velocity (57.75 ± 17.49 and 12.29 ± 5.74) compared with the control group (67.17 ± 29.57 and 15.03 ± 7.52), even after control of covariates. Conclusion: Early-onset preeclampsia is associated with decreased blood flow of SMA in preterm infants on the first days of life. Faculdade de Medicina Universidade Estadual Paulista (UNESP) Instituto de Biociencias Universidade Estadual Paulista (UNESP) Faculdade de Medicina Universidade Estadual Paulista (UNESP) Instituto de Biociencias Universidade Estadual Paulista (UNESP)
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- 2019
112. Aspirin in the prevention of preeclampsia: the conundrum of how, who and when
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Renuka Shanmugalingam, Annemarie Hennessy, and Angela Makris
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medicine.medical_specialty ,Pregnancy ,Aspirin ,Dose-Response Relationship, Drug ,business.industry ,Early onset preeclampsia ,Anti-Inflammatory Agents, Non-Steroidal ,MEDLINE ,030204 cardiovascular system & hematology ,medicine.disease ,Preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Internal Medicine ,medicine ,Humans ,Female ,030212 general & internal medicine ,Intensive care medicine ,business ,medicine.drug - Abstract
Aspirin is widely used in preventing early onset preeclampsia in women who are identified as being high risk. Although the benefit of aspirin is increasingly evident and acknowledged, there remains many unanswered questions with regards to its optimal application in pregnancy. The issues mainly centre around the relatively modest risk reduction that is observed with the use of aspirin prophylactically. We aim to explore the reasons behind the conservative rate of benefit and aim to explore factors that are likely to influence the outcomes with the use of aspirin.
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- 2018
113. Comparison of serum soluble edoglin (sEng) level in eary onset preeclampsia, late onset preeclampsia and normal pregnant woman
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Mita Herdiyantini, Muhammad Ilham Aldika Akbar, and Aditiawarman Aditiawarman
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levels of soluble Endoglin (s-Eng) serum ,medicine.medical_specialty ,late onset preeclampsia ,business.industry ,Early onset preeclampsia ,Anti angiogenic ,Ischemia ,Normal pregnancy ,medicine.disease ,Late onset preeclampsia ,Gastroenterology ,female genital diseases and pregnancy complications ,early onset preeclampsia ,Preeclampsia ,Internal medicine ,medicine ,Soluble endoglin ,Endothelial dysfunction ,business ,reproductive and urinary physiology - Abstract
Objectives: This study aimed to compare the serum levels of soluble Endoglin (s-Eng) between early onset preeclampsia, late onset preeclampsia and normal pregnant women.Materials and Methods: This was an analytic observational study (Cross-Sectional) performed on 39 pregnant women with early-onset preeclampsia (EO-PE), late-onset preeclampsia (LO-PE), and normal pregnancy. The patients were consecutively chosen in Dr. Soetomo Hospital, Airlangga University Hospital and Dr. M. Soewandhi Hospital Surabaya in May-July 2016. The serum concentration of soluble Endoglin were collected by venous puncture taken from maternal circulation and measured by ELISA.Results: From this study, serum concentrations of soluble Endoglin was higher significantly on the early onset preeclampsia compared with late onset preeclampsia and normal pregnancy (47,65 ± 40,17 vs 13,46 ± 9,48 vs 6,11 ± 1,45 ng/mL; p=0.000). Conclusion: This study shows angiogenic imbalance was more prominent compared in early-onset than late-onset preeclampsia. This may be because the placental dysfunction, placental ischemia, which produce excessive anti angiogenic factors, whic later causing endothelial dysfunction was more related to early onset preeclampsia.
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- 2018
114. Fulminant severe HELLP syndrome in early onset preeclampsia: A case report
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A. Nikolov and N. Popovski
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Pediatrics ,medicine.medical_specialty ,business.industry ,HELLP syndrome ,Fulminant ,Early onset preeclampsia ,Internal Medicine ,Obstetrics and Gynecology ,Medicine ,business ,medicine.disease - Published
- 2019
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115. Evaluation of maternal serum progranulin levels in normotensive pregnancies, and pregnancies with early- and late-onset preeclampsia
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Mahmut Oncul, Abdullah Serdar Acikgoz, Abdullah Tuten, Onur Guralp, Arife Şimşek, Şerife Eskalen, Burcu Çakmak Dinçgez, and Mehmet Aytac Yuksel
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Adult ,medicine.medical_specialty ,Birth weight ,Blood Pressure ,Gestational Age ,Preeclampsia ,Progranulins ,Pre-Eclampsia ,Pregnancy ,medicine ,Birth Weight ,Humans ,Uncomplicated pregnancy ,Gynecology ,business.industry ,Early onset preeclampsia ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Late onset preeclampsia ,Pathophysiology ,Uterine Artery ,C-Reactive Protein ,Cross-Sectional Studies ,Pulsatile Flow ,Pediatrics, Perinatology and Child Health ,Immunology ,Intercellular Signaling Peptides and Proteins ,Female ,business - Abstract
To investigate the possible pathophysiological associations between progranulin (PGRN) and preeclampsia (PE), early-onset PE (EOPE) and late-onset PE (LOPE).A cross-sectional study was designed to include consecutive patients with uncomplicated pregnancy (n = 28), EOPE (n = 30) and LOPE (n = 22). Maternal levels of serum PGRN were measured with the use of an enzyme-linked immunosorbent assay kit.The mean serum PGRN level was significantly higher in women with PE compared to the control group (54.17 ± 4.20 pg/ml versus 42.37 ± 5.64 pg/ml, p0.001), in the LOPE group compared to the control group (51.63 ± 4.61 pg/ml versus 42.37 ± 5.64 pg/ml, p0.001) and also in women with EOPE compared to women with LOPE (56.03 ± 2.68 pg/ml versus 51.63 ± 4.61 pg/ml, p0.001). Serum PGRN was negatively correlated with gestational age at birth (r = -0.669, p = 0.001) and birth weight (r = -0.653, p = 0.001); and positively correlated with systolic (r = 0.653, p = 0.001) and diastolic blood pressure (r = 0.601, p = 0.001), C-reactive protein (r = 0.519, p = 0.001), uterine artery pulsatility (r = 0.441, p = 0.001) and resistance indices (r = 0.441, p = 0.001).Serum PGRN levels increase significantly in women with PE as an indirect sign of placental dysfunction. This increase is even more prominent in women with EOPE. The serum PGRN in the third trimester is positively correlated with gestational age at birth and birth weight.
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- 2015
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116. Combination of PAPPA, fhCGβ, AFP, PlGF, sTNFR1, and Maternal Characteristics in Prediction of Early-onset Preeclampsia
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Markku Ryynanen, Heikki Kouru, Anna Yliniemi, Jaana Marttala, K. Mäkikallio, and Teemu Korpimaki
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Cultural Studies ,Placental growth factor ,early-onset preeclampsia ,Linguistics and Language ,History ,Microarray ,pregnancy-associated plasma protein A (PAPPA) ,Bioinformatics ,Logistic regression ,soluble tumor necrosis factor receptor-1 (sTNFR1) ,lcsh:Gynecology and obstetrics ,Language and Linguistics ,Human chorionic gonadotropin ,Preeclampsia ,Andrology ,medicine ,alpha-fetoprotein (AFP) ,free β-subunit of human chorionic gonadotropin (fhCGβ) ,placental growth factor (PlGF) ,lcsh:RG1-991 ,Original Research ,business.industry ,Early onset preeclampsia ,lcsh:Public aspects of medicine ,lcsh:RA1-1270 ,medicine.disease ,Control subjects ,Blood proteins ,Anthropology ,business - Abstract
Objective To evaluate the efficacy of first-trimester markers–-pregnancy-associated plasma protein A (PAPPA), free human chorionic gonadotropin β (fhCGβ), alpha-fetoprotein (AFP), placental growth factor (PlGF), and soluble tumor necrosis factor receptor-1 (sTNFR1) together with maternal characteristics (MC) for prediction of early-onset preeclampsia (EOPE). Methods During 2005-2010, the abovementioned biomarkers were analyzed with logistic regression analysis in 64 EOPE and 752 control subjects to determine whether these biomarkers separately and in combination with MC would predict development of EOPE. Results PAPPA, fhCGβ, and PlGF levels were lower, whereas AFP and sTNFR1 levels were higher in mothers with EOPE compared to controls. The combination of all markers with MC (age, weight, and smoking status) detected 48% of the mothers with EOPE, with a 10% false-positive rate (FPR). Conclusions First-trimester maternal serum levels of PAPPA, fhCGβ, AFP, PlGF, and sTNFR1, together with MC, are predictive of development of subsequent EOPE. These markers, along with MC, form a suitable panel for predicting EOPE.
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- 2015
117. Role of IL-6 −174(G/C) promoter polymorphism in the etiology of early-onset preeclampsia
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Pratibha Nallari, Ananthapur Venkateshwari, Aruna Ramaiah, Sabnavis Sowmya, and Akka Jyothy
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Adult ,Aging ,medicine.medical_specialty ,Genotype ,Immunology ,Promoter polymorphism ,Inflammation ,Polymerase Chain Reaction ,Preeclampsia ,Gene Frequency ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Promoter Regions, Genetic ,Interleukin 6 ,Alleles ,Pharmacology ,Polymorphism, Genetic ,biology ,Interleukin-6 ,business.industry ,Early onset preeclampsia ,Interleukin ,medicine.disease ,Rheumatology ,Case-Control Studies ,biology.protein ,Etiology ,Female ,medicine.symptom ,business - Abstract
To investigate the relationship between IL-6 -174G/C promoter polymorphism and preeclampsia.A total of 140 preeclamptic women and 135 women with normal pregnancy were considered for the present study. A standard amplification refractory mutation system PCR was carried out for genotyping of IL-6 G-174C promoter polymorphism. Genotypic distribution was compared with values predicted by Hardy-Weinberg equilibrium using χ (2) test. Odds ratios and their respective 95 % confidence intervals were used to measure the strength of association.The frequencies observed, CC, GC and GG, were 53.5, 26.6 and 20 % in patients and 26.6, 23.7 and 49.6 % in the controls. There is a significant difference in the distribution of genotypes and alleles of IL-6 G-174 C between the two groups.The present study suggests that the IL-6 -174 promoter polymorphism is a major genetic regulator in the etiology of early-onset preeclampsia.
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- 2015
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118. Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia
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Matts Olovsson, Anders Larsson, Anna-Karin Wikström, and Katja Junus
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Adult ,Male ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Ultrasonography, Prenatal ,Preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Predictive Value of Tests ,Pregnancy ,Second trimester ,Natriuretic Peptide, Brain ,medicine ,Humans ,cardiovascular diseases ,Gynecology ,Chi-Square Distribution ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Early onset preeclampsia ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Plasma levels ,medicine.disease ,Peptide Fragments ,Case-Control Studies ,Pregnancy Trimester, Second ,embryonic structures ,Pediatrics, Perinatology and Child Health ,Biomarker (medicine) ,Female ,business ,Biomarkers ,hormones, hormone substitutes, and hormone antagonists - Abstract
Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53.0, 14.9-184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia.
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- 2016
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119. Assessment of the fullPIERS risk prediction model in women with early-onset preeclampsia
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J. Mark Ansermino, Shakila Thangaratinam, U. Vivian Ukah, Wessel Ganzevoort, Jennifer A. Hutcheon, Peter von Dadelszen, Beth A. Payne, Laura A. Magee, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, ARD - Amsterdam Reproduction and Development, Obstetrics and Gynaecology, and APH - Digital Health
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Adult ,medicine.medical_specialty ,Canada ,Gestational Age ,Risk Assessment ,Preeclampsia ,Decision Support Techniques ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Risk Factors ,Pregnancy ,Early Medical Intervention ,Internal Medicine ,Medicine ,Humans ,Model development ,030212 general & internal medicine ,10. No inequality ,Netherlands ,030219 obstetrics & reproductive medicine ,Receiver operating characteristic ,business.industry ,Obstetrics ,Early onset preeclampsia ,Pregnancy Outcome ,Infant, Newborn ,Gestational age ,Original Articles ,medicine.disease ,calibration ,Quality Improvement ,Confidence interval ,United Kingdom ,3. Good health ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Premature Birth ,Female ,prognosis ,business ,Risk assessment - Abstract
Supplemental Digital Content is available in the text., Early-onset preeclampsia is associated with severe maternal and perinatal complications. The fullPIERS model (Preeclampsia Integrated Estimate of Risk) showed both internal and external validities for predicting adverse maternal outcomes within 48 hours for women admitted with preeclampsia at any gestational age. This ability to recognize women at the highest risk of complications earlier could aid in preventing these adverse outcomes through improved management. Because the majority (≈70%) of the women in the model development had late-onset preeclampsia, we assessed the performance of the fullPIERS model in women with early-onset preeclampsia to determine whether it will be useful in this subgroup of women with preeclampsia. Three cohorts of women admitted with early-onset preeclampsia between 2012 and 2016, from tertiary hospitals in Canada, the Netherlands, and United Kingdom, were used. Using the published model equation, the probability of experiencing an adverse maternal outcome was calculated for each woman, and model performance was evaluated based on discrimination, calibration, and stratification. The total data set included 1388 women, with an adverse maternal outcome rate of 7.3% within 48 hours of admission. The model had good discrimination, with an area under the receiver operating characteristic curve of 0.80 (95% confidence interval, 0.75–0.86), and a calibration slope of 0.68. The estimated likelihood ratio at the predicted probability of ≥30% was 23.4 (95% confidence interval, 14.83–36.79), suggesting a strong evidence to rule in adverse maternal outcomes. The fullPIERS model will aid in identifying women admitted with early-onset preeclampsia in similar settings who are at the highest risk of adverse outcomes, thereby allowing timely and effective interventions.
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- 2018
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120. Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia
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J. Li, Dong J, Liu Xr, Wang Xt, Qingyou Liu, Ji M, and Fei Gao
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Adult ,Risk ,medicine.medical_specialty ,Genetic Linkage ,Gene Expression ,Logistic regression ,Bioinformatics ,Polymorphism, Single Nucleotide ,Gastroenterology ,Preeclampsia ,Asian People ,Gene Frequency ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Genotype ,Odds Ratio ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Promoter Regions, Genetic ,Molecular Biology ,Gene ,Alleles ,business.industry ,Early onset preeclampsia ,General Medicine ,Odds ratio ,medicine.disease ,Confidence interval ,Interleukin-10 ,Interleukin 10 ,Early Diagnosis ,Logistic Models ,Female ,business - Abstract
In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in conformance with Hardy-Weinberg equilibrium (HWE; P = 0.46 and 0.17). Unconditional logistic regression analyses revealed that individuals carrying the CC genotype of IL-10 -819T/C were associated with an increased risk of preeclampsia compared to the TT genotype. The odds ratio (95% confidence interval) for the CC genotype of IL-10 -819T/C was 1.71 (1.07-3.27) compared to the TT genotype. In conclusion, the results of our study indicated that the IL-10 -819T/C polymorphism was associated with an increased risk of preeclampsia in a Chinese population.
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- 2015
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121. Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study
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Karl Egan, Cathy Monteith, Fergal D. Malone, Barry Kevane, Sharon Cooley, Patricia B. Maguire, Hugh O'Connor, Fionnuala Ní Áinle, and Paulina B. Szklanna
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Adult ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Preeclampsia ,Time-to-Treatment ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Medicine ,Humans ,Mean platelet volume ,Pregnancy Trimesters ,Correlation of Data ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Proteinuria ,business.industry ,Obstetrics ,Early onset preeclampsia ,Obstetrics and Gynecology ,Retrospective cohort study ,Guideline ,medicine.disease ,Early Diagnosis ,Pediatrics, Perinatology and Child Health ,Hypertension ,Female ,medicine.symptom ,business ,Ireland ,Mean Platelet Volume - Abstract
Objective: To characterise Mean platelet volume (MPV) in patients with early onset preeclampsia (EOPE) and unaffected controls from time of first antenatal visit until the postpartum. Materials and methods: Retrospective secondary analysis of an observational study in an Irish tertiary referral centre with 9000 deliveries annually. The MPV of 27 women with EOPE was compared to 19 unaffected controls. The inclusion criteria for the disease state was the development of EOPE defined by the National Institute for Health and Care Excellence (NICE) guideline, as new onset hypertension presenting after 20 weeks and prior to 34 weeks with significant proteinuria. Between October 2013 and July 2015 we recruited 27 women with EOPE and 19 pregnant controls. Statistical analysis was performed using paired T-test of Mann-Whitney test where appropriate and a P-value Results: At time of diagnosis and late in the third trimester MPV was significantly increased to 9.0 (±0.3) fL in cases of EOPE in comparison to 8.5 (±0.6) fL in normotensive controls (P Conclusion: Despite an increased MPV at time of diagnosis of EOPE this study did not demonstrate a potential use for increased MPV as a first trimester screening tool.
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- 2017
122. Evaluation of maternal serum hypoxia inducible factor-1α, progranulin and syndecan-1 levels in pregnancies with early- and late-onset preeclampsia
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Ebru Alici Davutoglu, Asuman Akkaya Firat, Isil Uzun, Ilkbal Temel Yuksel, Nevin Yilmaz, Ayşegül Özel, and Riza Madazli
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0301 basic medicine ,Adult ,medicine.medical_specialty ,Normal pregnancy ,Preeclampsia ,Syndecan 1 ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Progranulins ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,medicine ,Humans ,Statistical analysis ,030219 obstetrics & reproductive medicine ,business.industry ,Early onset preeclampsia ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Late onset preeclampsia ,Hypoxia-Inducible Factor 1, alpha Subunit ,030104 developmental biology ,Endocrinology ,Cross-Sectional Studies ,Hypoxia-inducible factors ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Intercellular Signaling Peptides and Proteins ,Female ,Syndecan-1 ,business ,Biomarkers - Abstract
To determine the serum levels of HIF-1 α, progranulin, and syndecan-1 in preeclampsia (PE) and normal pregnancy, and to compare whether these markers demonstrate any difference between early-onset PE (EO-PE) and late-onset PE (LO-PE).This cross-sectional study was conducted on 27 women with EO-PE, 27 women with LO-PE, and 26 healthy normotensive pregnant controls matched for gestational age. Maternal levels of serum HIF-1 α, progranulin, and syndecan-1 were measured with the use of an enzyme-linked immunosorbent assay kit.Statistical analysis revealed significant differences between the control and the PE groups in progranulin (p .001) and syndecan-1 (p .001) levels. There were no significant differences in the serum HIF-1 α levels between these groups (p= .069). When PE patients were evaluated by considering subgroups; statistical analysis revealed significant inter-group differences in all biomarkers. Serum progranulin levels were significantly higher in LO-PE compared with the other two groups (EO-PE versus LO-PE and LO-PE versus controls p = .000). Control group presented significantly higher syndecan-1 levels, than EO and LO-PE (p .001). HIF-1 α levels positively correlated with progranulin levels (r = .439, p= .000).Serum progranulin may have potential to be used as a biomarker for the differentiation of EO-PE and LO-PE. The co-operative action between HIF-1 α and progranulin might play a key role in the pathogenesis of LO-PE. The predominant feature of LO-PE seems to be an inflammatory process, whereas in EO-PE placentation problem seems to be the main pathology.
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- 2017
123. Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity
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Anton F.J. de Haan, Joris J.A. van Esch, Olivier W.H. van der Heijden, and Arno van Heijst
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Adult ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Perinatal outcome ,Gestational Age ,Infant, Newborn, Diseases ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,Preeclampsia ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,medicine ,Humans ,030212 general & internal medicine ,Age of Onset ,Perinatal Mortality ,Netherlands ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Perinatal mortality ,business.industry ,Obstetrics ,Early onset preeclampsia ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Neonatal morbidity ,Neonatal outcomes ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Female ,Morbidity ,business ,Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] - Abstract
Contains fulltext : 182476.pdf (Publisher’s version ) (Open Access) OBJECTIVE: To evaluate neonatal outcomes of pregnancies complicated by early-onset preeclampsia (PE) and compare these outcomes to those of gestational age matched neonates born to mothers whose pregnancy was not complicated by early-onset PE. METHODS: We analyzed the outcome in 97 neonates born to mothers with early-onset PE (24-32 weeks amenorrhea at diagnosis) and compared it to that of 680 gestational age-matched neonates born between 25-36 weeks due to other etiologies and admitted to the Neonatal Intensive Care Unit (NICU) of a tertiary referral hospital in the Netherlands. We used Chi-square test, Wilcoxon test, and logistic regression analyses. RESULTS: Neonates born to PE mothers had a higher perinatal mortality (13% vs. 7%, p = 0.03) and infant mortality (16% vs. 9%, p= 0.03), a 20% lower birth weight (1150 vs. 1430 g, p
- Published
- 2017
124. An analysis of expectant management in women with early-onset preeclampsia in China
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Yifei Gao, Qi Wen Chen, F. Shen, and Min Zhao
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Adult ,medicine.medical_specialty ,Adolescent ,Renal function ,Preeclampsia ,Pre-Eclampsia ,Pregnancy ,Internal Medicine ,Humans ,Medicine ,Fetal Death ,reproductive and urinary physiology ,Expectant management ,Retrospective Studies ,Fetus ,business.industry ,Obstetrics ,Early onset preeclampsia ,Middle Aged ,medicine.disease ,Severe preeclampsia ,female genital diseases and pregnancy complications ,Biomarker (medicine) ,Female ,business - Abstract
Preeclampsia is a pregnancy-specific disorder and a leading cause of morbidity and mortality in both women and fetus. Although women with early severe preeclampsia are generally considered to require expedious delivery, expectant management may benefit for pregnancy prolongation. We performed a retrospective analysis of expectant management in early-onset preeclampsia, with or without fetal grow restriction (FGR) over a 6-year period, to investigate whether these women benefit from expectant management. Data including clinical parameters and liver and renal function from 186 nulliparous women with early-onset preeclampsia were analysed. In women with early-onset preeclampsia, 76.8% were delivered after 48 h and the median pregnancy prolongation was 8 days, whereas 23.2% were delivered within 48 h. There was no difference in maternal parameters, liver or renal functions between women in these two groups, regardless of the severity of preeclampsia. However, the stillbirth number was higher in preeclamptic women delivered after 48 h compared with those delivered within 48 h. Our study demonstrates that the decision for immediate delivery or expectant management was not associated with clinical parameter or laboratory biomarker of liver and renal function. However, the risk of stillbirth should still be taken into consideration when making the decision for immediate delivery or expectant management in the clinic.
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- 2014
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125. Complement and coagulation cascades is the main pathway involved in early onset preeclampsia revealed by maternal blood proteomics
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M. Palomo, H. Garcia, E. Gratacós, Fatima Crispi, Josep M. Campistol, Miquel Blasco, Joan Carles García-Pagán, L. Youssef, Ana Paula Dantas, and Maribel Diaz-Ricart
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Coagulation ,business.industry ,Early onset preeclampsia ,Immunology ,Internal Medicine ,Obstetrics and Gynecology ,Medicine ,Maternal blood ,business ,Proteomics ,Complement (complexity) - Published
- 2019
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126. Conditional Deletion of Phd2 in Spongiotrophoblasts Mimics Early Onset Preeclampsia
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Martin Post, Isabella Caniggia, Julien Sallais, Tyler R. Porter, and Chanho Park
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medicine.medical_specialty ,Endocrinology ,Reproductive Medicine ,business.industry ,Internal medicine ,Early onset preeclampsia ,Obstetrics and Gynecology ,Medicine ,business ,Developmental Biology - Published
- 2019
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127. First trimester Doppler velocimetry of the uterine artery ipsilateral to the placenta improves ability to predict early-onset preeclampsia
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Xiaojing Wang, Yang Jiao, Xian-Ying Liu, Christopher M. Morosky, Gui-Ying Zheng, Wen-Ling Song, Shu-Jing Shi, and Yan-Hui Zhao
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First trimester ,Adult ,medicine.medical_specialty ,Observational Study ,Ultrasonography, Prenatal ,Preeclampsia ,preeclampsia ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,placental laterality ,Placenta ,medicine.artery ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Uterine artery ,Prospective cohort study ,reproductive and urinary physiology ,uterine artery Doppler ,business.industry ,Obstetrics ,Early onset preeclampsia ,General Medicine ,Laser Doppler velocimetry ,medicine.disease ,female genital diseases and pregnancy complications ,Uterine Artery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,business ,Research Article - Abstract
This study sought to investigate the effects of placental laterality on the measurements of uterine artery (UtA) Doppler velocimetry and their application in predicting early-onset preeclampsia (PE). We conducted a prospective cohort study on all women with singleton, uncomplicated pregnancies scheduled for first-trimester nuchal translucency at our institution. Pulsatility index (PI) for both UtAs was measured by Doppler velocimetry, and placental laterality was determined. Additionally, pregnancy outcome data were abstracted from the medical records. Receiver operating characteristic curves (ROCs) were plotted. Of the 304 patients enrolled, 247 met the inclusion criteria. Among these patients, 240 had uncomplicated delivery, while 7 had early delivery at
- Published
- 2019
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128. Early Onset Preeclampsia Diagnosis Prior to the 20th Week of Gestation in a Twin Pregnancy Managed via Selective Reduction of an Intrauterine Growth Restriction Fetus: A Case Report and Literature Review.
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Konstantopoulos, Anastasios, Sfakianoudis, Konstantinos, Simopoulou, Mara, Kontogeorgi, Adamantia, Rapani, Anna, Grigoriadis, Sokratis, Pantou, Agni, Bathrellos, Nikolaos, Grammatis, Alexandros, and Pantos, Konstantinos
- Subjects
FETAL development ,ABORTION ,PREECLAMPSIA ,PREGNANCY ,LITERATURE reviews - Abstract
A single, healthy, 44-year-old perimenopausal woman pursuing a pregnancy, employed donor embryos, resulting to a dichorionic diamniotic twin pregnancy. In the 18th week of gestation severe symptoms indicated early onset preeclampsia reporting severe hypertension (BP 180/90 mmHg), intense headaches and nausea as well as elevated 24-h urine protein levels (1.5 g/day). Concurrently diagnosis of an IUGR fetus was concluded. Standard pharmaceutical administration for treating preeclampsia was ordered. Persistence of symptoms indicated recommendation for pregnancy termination, however the patient opted against this. Selective embryo reduction was performed as the last resort prior to pregnancy termination. Following selective reduction the headaches and nausea were successfully subdued and the patient's blood pressure was adjusted (mean BP 130/80 mmHg). This enabled further progression of pregnancy for an impressive 11 week-period, and a live birth on the 30th week. To conclude, only a few rare cases have been reported with diagnosis of early onset preeclampsia prior to the 20th week mark and none report live births. Albeit termination of pregnancy was recommended, the management of selective reduction of the IUGR fetus enabled successful treatment of preeclampsia coupled by a live birth of a healthy infant without any perinatal or postnatal complications reported. [ABSTRACT FROM AUTHOR]
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- 2020
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129. External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia
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van Kuijk, S.M., Delahaije, D.H., Dirksen, C., Scheepers, H.C., Spaanderman, M.E., Ganzevoort, W., Duvekot, J.J., Oudijk, M.A., van Pampus, M.G., von Dadelszen, P., Peeters, L.L., PreCare study group, the, Smits, L.J., Epidemiologie, MUMC+: KIO Kemta (9), Health Services Research, Obstetrie & Gynaecologie, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - Health Technology Assessment, RS: CAPHRI - Clinical epidemiology, RS: GROW - Developmental Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Obstetrics & Gynecology, Amsterdam Public Health, and Obstetrics and Gynaecology
- Subjects
Adult ,medicine.medical_specialty ,DIAGNOSIS ,Risk Assessment ,Preeclampsia ,1ST PREGNANCY ,DELIVERY ,Risk groups ,Pre-Eclampsia ,Predictive Value of Tests ,Pregnancy ,Recurrence ,Internal Medicine ,medicine ,Humans ,COHORT ,Registries ,Pregnancy outcomes ,Early onset ,Gynecology ,RISK ,Early-onset ,Receiver operating characteristic ,business.industry ,Obstetrics ,HYPERTENSIVE DISORDER ,Early onset preeclampsia ,External validation ,Obstetrics and Gynecology ,WOMEN ,Models, Theoretical ,medicine.disease ,LOW-PLASMA-VOLUME ,Cohort ,Female ,business ,Prediction - Abstract
Objective: To validate a previously published prediction model for recurrent early-onset preeclampsia (PE). Methods: We included 229 pregnant women with a history of early-onset PE and computed their risk using the prediction model, compared the predicted risk to their pregnancy outcomes and assessed performance of the model. Results: Early-onset PE recurred in 6.6% of participants. The area under the receiver operating characteristic curve was 59% (95% CI: 45-73). The model created groups that were only moderately different in terms of their risk. Conclusions: The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups.
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- 2014
130. In case you missed it: thePrenatal Diagnosissection editors bring you the most significant advances of 2013
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Alessandro Ghidini, Tim Van Mieghem, Brigitte H. W. Faas, Diana W. Bianchi, Lyn S. Chitty, Jan Deprest, and Lisa G. Shaffer
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medicine.medical_specialty ,business.industry ,Obstetrics ,Early onset preeclampsia ,Mother infant ,Obstetrics and Gynecology ,Twin twin transfusion ,University hospital ,humanities ,Child health ,Obstetrics and gynaecology ,Family medicine ,medicine ,University medical ,business ,health care economics and organizations ,Genetics (clinical) - Abstract
Mother Infant Research Institute at Tufts Medical Center, Boston, Massachusetts, USA Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane Washington, USA Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust and University College Hospital NHS Foundation Trust, London, UK Inova Alexandria Hospital, Alexandria, Virginia, USA *Correspondence to: Diana W. Bianchi. E-mail: dbianchi@tuftsmedicalcenter.org
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- 2014
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131. Correlation of serum collectrin level and preeclampsia onset: A case control study.
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Al-Bayati MMJ, Al-Ani ART, and Ahmed HN
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- Adult, Blood Pressure, Case-Control Studies, Female, Gestational Age, Humans, Iraq, Pre-Eclampsia blood, Pregnancy, Prospective Studies, Membrane Glycoproteins blood
- Abstract
Background: Pre-eclampsia is a major contributor to pregnancy-associated morbidity and mortality and the management of this complex syndrome needs to be improved. Recently serum collectrin has emerged as a new member of the renin-angiotensin system that regulates the blood pressure through nitric oxide -endothelial nitric oxide synthase pathway., Objective: To evaluate the correlation of serum collectrin level and preeclampsia onset., Study Design: A prospective case control study., Patients and Methods: Ninety pregnant women attended the outpatient clinic Al-Yarmook Teaching Hospital in Baghdad / Iraq along the period from April 2018 until December 2018 had been divided into three groups. Group A included 30 pregnant women presented with early onset pre-eclampsia (before 34 weeks of gestation), group B included 30 pregnant women presented with late onset pre-eclampsia (at or after 34 weeks of gestation) and group C included 30 apparently healthy term pregnant women. Serum collectrin levels were measured for each pregnant woman by using enzyme-linked immunosorbent assay analyzer., Results: The mean serum collectrin was the lowest in pregnant women with early onset pre-eclampsia (61.65 ± 3.62 pg/ml) while it was (82.61 ± 6.41 pg/ml) for pregnant women with late onset pre-eclampsia and (101.11 ± 8.27 pg/ml) for healthy term pregnant women. These differences were found to be significant (p value = 0.001). This significant decrement was inversely correlated with the systolic blood pressure (r = -0.565, p-value = 0.001) and diastolic blood pressure and (r = -0.748, p-value = 0.001)., Conclusion: Serum collectrin levels had a significant role in controlling the blood pressure in pregnant women with a significant inverse correlation between serum collectrin concentrations and blood pressure., (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)
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- 2021
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132. Hypertension in Pregnancy
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Alyssa Politzer, Michelle Y. Owens, Sarah Son, Geroge R. Saade, Ira M. Bernstein, Bahaeddine M Sibai, Maurice L. Druzin, Eleni Tsigas, Phyllis August, S. Ananth Karumanchi, Joey P. Granger, Donna D. Johnson, Robert R. Gaiser, Marshall D. Lindheimer, Nancy O'Reilly, John R. Barton, George Bakris, Catherine Y. Spong, Karina Ngaiza, Gerald E. Joseph, Arun Jeyabalan, and James M. Roberts
- Subjects
Pregnancy ,medicine.medical_specialty ,Executive summary ,Obstetrics ,business.industry ,Early onset preeclampsia ,Hypertension in Pregnancy ,MEDLINE ,Obstetrics and Gynecology ,Hypertensive disorder ,Postpartum Hypertension ,Late onset preeclampsia ,medicine.disease ,medicine ,business - Published
- 2013
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133. Review: Potential druggable targets for the treatment of early onset preeclampsia
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John W. Downing, R. L. Paschall, Raymond F. Johnson, and Curtis L. Baysinger
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Pregnancy ,Aspirin ,Fetus ,business.industry ,Offspring ,Early onset preeclampsia ,Druggability ,Obstetrics and Gynecology ,medicine.disease ,Bioinformatics ,Preeclampsia ,Clinical trial ,Immunology ,Internal Medicine ,medicine ,business ,medicine.drug - Abstract
Placental delivery is the only known cure for early onset preeclampsia, a major cause of maternal and neonatal morbidity and mortality worldwide. Prolonging pregnancy beyond 25weeks without undue maternal risk favors fetal survival, improves neonatal outcome and saves money. In vitro experiments using human placental tissue and in vivo studies employing "preeclamptic" animal models reveal the presence of likely druggable targets, especially within the maladapted intracellular nucleotide transduction pathways of preeclampsia. This review focuses on some novel pharmacological treatment options targeting early onset severe preeclampsia. Human and animal derived experimental data support the possible roles of nitric oxide donors (glyceryltrinitrate), aspirin, dietary supplements (calcium, l-Arginine, anti-oxidant vitamins), phosphodiesterase-5 inhibitors, statins, carbon monoxide and most recently, hydrogen sulfide. Extension of pregnancy or improvement of the disorder using means applicable in under resourced areas of the world would have a major positive impact on women's health globally. We therefore advocate the immediate launch of clinical trials testing simple innovative therapies in large obstetric units of developing countries such as South Africa or Brazil where preeclampsia is endemic and a regular killer of both mothers and offspring.
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- 2013
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134. Novel Therapy for the Treatment of Early-Onset Preeclampsia
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Sara Ornaghi, Michael J. Paidas, Ornaghi, S, and Paidas, M
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medicine.medical_specialty ,placenta ,angiogenic imbalance ,Disease ,030204 cardiovascular system & hematology ,Pharmacologic intervention ,Preeclampsia ,preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Obstetrics and gynaecology ,Pre-Eclampsia ,Pregnancy ,medicine ,Humans ,Intensive care medicine ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Early onset preeclampsia ,Obstetrics and Gynecology ,medicine.disease ,Perinatal morbidity ,Maternal Mortality ,endothelial dysfunction ,inflammation ,Drug Design ,Female ,business - Abstract
Preeclampsia is a multisystem disorder affecting 2% to 8% of pregnancies and a leading cause of maternal and perinatal morbidity and mortality worldwide. Recent investigations have improved our understanding of the pathogenesis of this potentially life-threatening disease, especially in its early-onset form of manifestation. Despite these advances, therapeutic options are still limited and no effective pharmacologic interventions are currently available. Ongoing lines of research indicate some potential novel treatments targeting specific pathogenic steps. In this article we provide an updated overview of the multiple therapeutic approaches under preclinical and clinical assessment for the treatment of early-onset preeclampsia.
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- 2016
135. Association between placental growth factor levels in early onset preeclampsia with the occurrence of postpartum hemorrhage: A prospective cohort study
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Sanjib Kumar Ghosh, Shashi Raheja, Chitra Raghunandan, Sneh Agarwal, and Anita Tuli
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Placental growth factor ,Gynecology ,medicine.medical_specialty ,business.industry ,Early onset preeclampsia ,Obstetrics and Gynecology ,Logistic regression ,medicine.disease ,Preeclampsia ,Increased risk ,Internal Medicine ,Gestation ,Medicine ,Population study ,business ,Prospective cohort study ,reproductive and urinary physiology - Abstract
To determine the association between PlGF (placental growth factor) estimation in early second trimester (22-24weeks of gestation), with the occurrence of postpartum hemorrhage in pregnant women with early onset preeclampsia and whether the mode of delivery (cesarean or vaginal) has any association with increased risk of developing postpartum hemorrhage.A prospective cohort study was conducted on 788 pregnant women with singleton pregnancies diagnosed with early onset preeclampsia between March 2009 and June 2011. Maternal serum PlGF level estimation was done between 22 and 24weeks of gestation and a cut-off value of122pg/ml was determined by receiver operating characteristic (ROC) curve analysis for identifying those at risk of developing postpartum hemorrhage. Association between serum PlGF level122pg/ml and cesarean deliveries with the risk of developing postpartum hemorrhage was analyzed by logistic regression analysis and Odds ratio, which were computed. The results were considered statistically significant when P-value0.05.Proportion of study population developing postpartum hemorrhage.Logistic regression analysis showed the association of serum PlGF122pg/ml at 22-24weeks (Odds ratio 8.9516; 95% CI, 5.0728-15.7963) and that of cesarean delivery (Odds ratio 2.4252; 95% CI, 1.4573-4.0360) with the risk of developing postpartum hemorrhage. Both the associations were found to be statistically significant.Maternal serum PlGF level122pg/ml at 22-24weeks of gestation and cesarean delivery are both strongly associated with the risk of developing postpartum hemorrhage in pregnant women with early onset preeclampsia.
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- 2012
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136. Impaired autophagy and transthyretin protein aggregation in early onset preeclampsia
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Tomoko Shima, Tae Kusabiraki, Osamu Yoshino, Akemi Ushijima, Azusa Sameshima, Aiko Aoki, Shigeru Saito, Akitoshi Nakashima, and Surendra Sharma
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medicine.medical_specialty ,biology ,business.industry ,Early onset preeclampsia ,Immunology ,Autophagy ,Obstetrics and Gynecology ,Protein aggregation ,Transthyretin ,Endocrinology ,Reproductive Medicine ,Internal medicine ,biology.protein ,medicine ,Immunology and Allergy ,business - Published
- 2017
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137. Impaired autophagy and transthyretin protein aggregation in early onset preeclampsia
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Akitoshi Nakashima
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medicine.medical_specialty ,biology ,business.industry ,Early onset preeclampsia ,Autophagy ,Obstetrics and Gynecology ,Protein aggregation ,Transthyretin ,Endocrinology ,Reproductive Medicine ,Internal medicine ,medicine ,biology.protein ,business ,Developmental Biology - Published
- 2017
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138. [OP.5B.06] CONCENTRIC LEFT VENTRICULAR REMODELING IS ASSOCIATED WITH EARLY ONSET PREECLAMPSIA IN WOMEN WITHOUT PREEXISTENT HYPERTENSION
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Francesca Pezzutto, L. Martorana, Valentina Fagotto, L.A. Sechi, A. Rossi, Cristiana Catena, Lorenza Driul, and G.L. Colussi
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medicine.medical_specialty ,Physiology ,business.industry ,Early onset preeclampsia ,Internal medicine ,Internal Medicine ,medicine ,Cardiology ,Concentric ,Cardiology and Cardiovascular Medicine ,business ,Ventricular remodeling ,medicine.disease - Published
- 2017
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139. 924: First trimester early-onset preeclampsia and expanded down syndrome screening: Maternal race/ethnicity adjustments
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Hsiao-Pin Liu, Terrence W. Hallahan, and David A. Krantz
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Down syndrome screening ,medicine.medical_specialty ,Race ethnicity ,First trimester ,Obstetrics ,business.industry ,Early onset preeclampsia ,medicine ,Obstetrics and Gynecology ,business - Published
- 2019
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140. Increased Postnatal Inflammation in Mechanically Ventilated Preterm Infants Born to Mothers with Early-Onset Preeclampsia
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Irmeli Nupponen, Hannele Laivuori, Eero Kajantie, Sture Andersson, Heikki Repo, Sanna Siitonen, and R Turunen
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Adult ,medicine.medical_specialty ,Neutrophils ,Birth weight ,Gestational Age ,Inflammation ,Monocytes ,Preeclampsia ,Leukocyte Count ,Obstetric Labor, Premature ,Pre-Eclampsia ,Pregnancy ,medicine ,Birth Weight ,Humans ,reproductive and urinary physiology ,Phagocytes ,Respiratory Distress Syndrome, Newborn ,CD11b Antigen ,Respiratory distress ,biology ,business.industry ,Obstetrics ,Early onset preeclampsia ,C-reactive protein ,Infant, Newborn ,Gestational age ,medicine.disease ,Respiration, Artificial ,female genital diseases and pregnancy complications ,Fetal Diseases ,C-Reactive Protein ,Pediatrics, Perinatology and Child Health ,biology.protein ,Premature Birth ,Female ,medicine.symptom ,business ,Infant, Premature ,Developmental Biology - Abstract
Background: Preeclampsia and preterm labor often underlie preterm birth, and are associated with maternal inflammation. In preterm infants, respiratory distress syndrome (RDS) and mechanical ventilation are associated with systemic inflammation. Objective: We aimed to study whether early-onset preeclampsia or preterm labor modulate the systemic inflammation affecting preterm infants with RDS. Methods: We recruited mechanically ventilated infants with gestational ages Results: As compared with infants born after preterm labor, infants born after early-onset preeclampsia had higher CD11b expression on days 1–6 on both neutrophils and monocytes. In addition, infants born after early-onset preeclampsia had higher CRP concentrations on days 2–6 (all p < 0.05). Conclusions: As compared with infants born after preterm labor to mothers without preeclampsia, infants born after early-onset preeclampsia presented with a stronger postnatal systemic inflammatory reaction. Antenatal exposure to preeclampsia may induce fetal leukocyte priming and regulation of inflammation, and thereby modify postnatal inflammatory reactions and morbidity.
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- 2011
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141. 8. Maternal recall of a history of early-onset preeclampsia, late-onset preeclampsia or gestational hypertension: a questionnaire study
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Pim W. Teunissen, Laurien J. Zeverijn, Anouk Bokslag, Christianne J.M. de Groot, and Anne B. Fons
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Gestational hypertension ,Pregnancy ,medicine.medical_specialty ,Recall ,business.industry ,Obstetrics ,Early onset preeclampsia ,Maternal recall ,Obstetrics and Gynecology ,030204 cardiovascular system & hematology ,medicine.disease ,Late onset preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Internal Medicine ,Medicine ,030212 general & internal medicine ,business ,Questionnaire study - Abstract
Objective: This study assessed women’s ability to recall different types of hypertensive disorders of pregnancy because of its disproportionate cardiovascular risk later in life. Methods: Participa...
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- 2018
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142. Expression of MMP 9 and TIMP 1 in human placenta from early onset preeclampsia
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Arora Pallavi, Mochan Sankat, Rani Neerja, Kshetrapal Pallavi, Sharma Arundhati, Dhingra Renu, Luthra kalpana, Gupta Sunil, Saxena Shobhit, and Bhatla Neerja
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Andrology ,business.industry ,Early onset preeclampsia ,Medicine ,Human placenta ,Anatomy ,Matrix metalloproteinase ,business ,Pathology and Forensic Medicine - Published
- 2018
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143. High performance of maternal characteristics and assessment of uterine artery Doppler waveform for the prediction of early-onset preeclampsia
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Lionel Carbillon
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medicine.medical_specialty ,Uterus ,Ultrasonography, Prenatal ,symbols.namesake ,Pre-Eclampsia ,Predictive Value of Tests ,Pregnancy ,Internal medicine ,medicine.artery ,medicine ,Humans ,Waveform ,Uterine artery ,business.industry ,Early onset preeclampsia ,Uterine artery doppler ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,medicine.disease ,Pregnancy Trimester, First ,Uterine Artery ,medicine.anatomical_structure ,Predictive value of tests ,symbols ,Cardiology ,Female ,business ,Doppler effect - Published
- 2018
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144. Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia
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Helena Åkerud, Anders Larsson, Anna-Karin Olsson, Anna-Karin Wikström, Karin Kårehed, and Matts Olovsson
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Adult ,medicine.medical_specialty ,Histidine-rich glycoprotein ,Placenta ,Gestational Age ,Fibrinogen ,Preeclampsia ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Tissue Distribution ,Blood Coagulation ,reproductive and urinary physiology ,business.industry ,Early onset preeclampsia ,Pregnancy Outcome ,Endothelial Cells ,Proteins ,Obstetrics and Gynecology ,Gestational age ,General Medicine ,medicine.disease ,Immunohistochemistry ,Endocrinology ,Coagulation ,Female ,business ,medicine.drug - Abstract
OBJECTIVE: To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia. DESIGN: The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestational weeks 35-42) preeclampsia. As controls concerning the plasma levels of fibrinogen, we used samples from non-pregnant fertile women, healthy pregnant women at gestational weeks 24-32 and healthy pregnant women at gestational weeks 35-42. Placental samples from women with healthy pregnancies at gestational weeks 35-42 served as controls in the immunohistochemical staining. SETTING: Uppsala University Hospital, Uppsala. METHODS: Plasma fibrinogen levels were analyzed and the placental tissue expression of fibrinogen and HRG determined by immunohistochemistry. RESULTS: Plasma level of fibrinogen was increased in early-onset, but not late-onset, preeclampsia. Levels of fibrinogen were significantly lower, and that of HRG significantly higher, in placentas from women with early-onset preeclampsia as compared with control placentas (p = 0.01 and 0.001). CONCLUSIONS: HRG and fibrinogen might be involved in the hypercoagulability and the angiogenic imbalance seen in early-onset preeclampsia.
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- 2010
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145. Protective role of maternal p.Val158Met catechol-omethyltransferase polymorphism against early-onset preeclampsia and its complications
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Ljiljana Mirkovic, Tijana Krnjeta, Dragana Tomasevic, Ivan Soldatovic, Jelena Lukic, Nada Majkić-Singh, Drina Topalov, and Svetlana Ignjatović
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0301 basic medicine ,early-onset preeclampsia ,Candidate gene ,medicine.medical_specialty ,sga ,CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM ,Gastroenterology ,Preeclampsia ,polymorphism ,lcsh:Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Disease severity ,Internal medicine ,Genotype ,Medicine ,lcsh:QD415-436 ,Allele ,comt ,SGA ,Original Paper ,030219 obstetrics & reproductive medicine ,business.industry ,Early onset preeclampsia ,severe ,Gestational age ,medicine.disease ,COMT ,030104 developmental biology ,nervous system ,business - Abstract
SummaryBackground: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE.Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis.Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference observed was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95%CI=0.092-0.7836) and PE complications including severe early-onset PE (OR= 0.304; 95%CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95%CI=0.081-0.874).Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.
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- 2016
146. Multicenter impact analysis of a model for predicting recurrent early-onset preeclampsia: A before-after study
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Luc J.M. Smits, Hubertina C.J. Scheepers, W. Ganzevoort, J.J. Duvekot, Carmen D. Dirksen, M.G. van Pampus, Martijn A. Oudijk, Denise H.J. Delahaije, Marc E. A. Spaanderman, Louis L. Peeters, S. M. J. van Kuijk, Obstetrics & Gynecology, MUMC+: KIO Kemta (9), Epidemiologie, Health Services Research, Obstetrie & Gynaecologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: CAPHRI - R5 - Optimising Patient Care, and Obstetrics and Gynaecology
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Adult ,Pediatrics ,medicine.medical_specialty ,recurrence ,Risk Assessment ,Preeclampsia ,preeclampsia ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Standard care ,Pre-Eclampsia ,Pregnancy ,Risk Factors ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Registries ,Young adult ,Reference group ,Before after study ,validation ,030219 obstetrics & reproductive medicine ,business.industry ,Early onset preeclampsia ,Pregnancy Outcome ,Obstetrics and Gynecology ,Models, Theoretical ,medicine.disease ,prediction model ,Impact ,Controlled Before-After Studies ,Female ,business ,Risk assessment - Abstract
Objective: This study aims to determine the impact of using a prediction model for recurrent preeclampsia to customize antenatal care in subsequent pregnancies. Methods: We compared care consumption, pregnancy outcomes, and self-reported health state of two risk-based subgroups, and compared these to a reference group receiving standard care. Results: We included a total of 311 women from 12 hospitals. Compared to standard care, recurrence-risk guided care did not lead to different outcomes or self-perceived health. Conclusion: Our study exemplifies that recurrence-risk-based stratification of antenatal care in former preeclampsia patients is feasible; it does not lead to worse pregnancy outcomes.
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- 2016
147. Effect of maternal omega-3 fatty acids and vitamin E supplementation on placental apoptotic markers in rat model of early and late onset preeclampsia.
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Kasture, Vaishali, Kale, Anvita, Randhir, Karuna, Sundrani, Deepali, and Joshi, Sadhana
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PREECLAMPSIA , *VITAMIN E , *OMEGA-3 fatty acids , *TRETINOIN , *PREGNANCY complications , *B cells , *OXIDATIVE stress - Abstract
Disturbed placentation results in pregnancy complications like preeclampsia. Placental development is influenced by apoptosis during trophoblast differentiation and proliferation. Increased oxidative stress upregulates placental apoptosis. We have earlier reported increased oxidative stress, lower omega-3 fatty acids and vitamin E levels in women with preeclampsia. Current study examines effect of maternal omega-3 fatty acids and vitamin E supplementation on apoptotic markers across gestation in a rat model of preeclampsia. Pregnant Wistar rats were randomly assigned to control; early onset preeclampsia (EOP); late onset preeclampsia (LOP); early onset preeclampsia + omega-3 fatty acid + vitamin E supplementation (EOP + O + E) and late onset preeclampsia + omega-3 fatty acid + vitamin E supplementation (LOP + O + E) groups. Animals (Control, EOP, EOP + O + E) were sacrificed at d14 and d20 of gestation while animals (LOP, LOP + O + E) were sacrificed at d20 to collect blood and placentae. Protein and mRNA levels of apoptotic markers were analyzed by ELISA and RT-PCR respectively. Protein levels of proapoptotic markers like Bcl-2 associated X-protein (BAX) (p < 0.05), caspase-8 and 3 (p < 0.01 for both) and malondialdehyde (p < 0.01) were higher only in the EOP group as compared to control. However, the antiapoptotic marker, B cell lymphoma 2 (Bcl-2) protein levels were lower in both the subtypes of preeclampsia (p < 0.01 for both). Our findings suggest that supplementation was beneficial in reducing the caspase-8 and 3 in early onset preeclampsia but did not normalize BAX and Bcl-2 levels. This has implications for reducing placental apoptosis in preeclampsia. [ABSTRACT FROM AUTHOR]
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- 2019
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148. Angiogenic markers sFlt-1 and PIGF can be used to predict the course of early-onset preeclampsia
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Daniel Surbek, Luigi Raio, Marc Baumann, and Z Tan
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Oncology ,medicine.medical_specialty ,PIGF ,business.industry ,Internal medicine ,Early onset preeclampsia ,Maternity and Midwifery ,Pediatrics, Perinatology and Child Health ,medicine ,Obstetrics and Gynecology ,business - Published
- 2015
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149. Magnesium sulphate can prolong pregnancy in patients with severe early-onset preeclampsia
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Akihiko Ueda, Eiji Kondoh, Kaoru Kawasaki, Yoshitsugu Chigusa, Ikuo Konishi, and Haruta Mogami
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Adult ,medicine.medical_specialty ,Pediatrics ,chemistry.chemical_element ,Gestational Age ,030204 cardiovascular system & hematology ,Statistics, Nonparametric ,Preeclampsia ,03 medical and health sciences ,Magnesium Sulfate ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Medicine ,Humans ,In patient ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Magnesium ,Platelet Count ,Early onset preeclampsia ,Pregnancy Outcome ,Obstetrics and Gynecology ,Historically Controlled Study ,Retrospective cohort study ,medicine.disease ,Severe preeclampsia ,Tocolytic Agents ,chemistry ,Pediatrics, Perinatology and Child Health ,Acute Disease ,Disease Progression ,Gestation ,Premature Birth ,Female ,business - Abstract
To assess whether long-term use of magnesium sulphate prolongs pregnancy in patients with severe early-onset preeclampsia.Retrospective cohort study included all singleton pregnancies with severe early-onset preeclampsia, expectantly managed in our institution between 2005 and 2013. Obstetric and perinatal outcomes were compared between patients managed using a current protocol that tolerates long-term (over 48 h) use of magnesium sulphate (long-term group, n = 26) and a historical control group (control group, n = 15) that underwent conventional treatment (up to 48 h use of magnesium sulphate).Long-term group showed significant prolongation of pregnancy compared with the control group (9.2 ± 7.9 versus 16.6 ± 9.3 d, log-rank test, p = 0.021), which was also observed in patients with severe preeclampsia occurring before 28 weeks' gestation (n = 11, 4.5 ± 5.2 versus 13.2 ± 6.8 d, log-rank test, p = 0.035). In contrast to a progressive decrease of platelet count in patients managed without magnesium sulphate, administration of magnesium sulphate for 7 d prevented the decrease of platelet count (p = 0.001). Thirty two percent of patients (13/41) experienced a major complication irrespective of duration of magnesium sulphate use.Long-term use of magnesium sulphate prolonged pregnancy in patients with severe early-onset preeclampsia and can help alleviate progression of preeclampsia.
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- 2015
150. PP089. A new expectant management of early-onset preeclampsia
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Y. Shen and L. Ren
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Gynecology ,medicine.medical_specialty ,Obstetrics ,business.industry ,Birth weight ,Early onset preeclampsia ,Ischemia ,Obstetrics and Gynecology ,Intrauterine growth restriction ,Gestational age ,medicine.disease ,Preeclampsia ,Continuous use ,Internal Medicine ,medicine ,business ,Expectant management - Abstract
Introduction Early-onset and severe preeclampsia (PE) is a leading cause of maternal and prenatal morbidity and mortality. It has been challenging for doctors to produce good outcomes for both preeclamptic mothers and their babies. Objectives To ameliorate this situation, a new expectant management was introduced in this study. Methods Umbilical blood velocity was monitored in 10 cases of early-onset preeclampsia patients who were treated continuously with magnesium sulfate accordingly. Results The average gestational age when PE initiated was 28±3 weeks (ranging from 23 to 31weeks). The mean days prolonged by expectant management were 32.5±23.6 days (ranging from 8 to 95days). The average gestational age at delivery was 34±1weeks (ranging from 31 +3 to 37weeks). The mean amount of magnesium sulfate used was 310.5±252.3g (ranging from 70 to 1000g). 10 pregnant women were all with abnormal umbilical blood velocity when admitted. All 10 babies were born alive. The mean birth weight was 1848±669g (ranging from 900 to 3120g). 9 (90%) babies were premature, and 6 (60%) babies had intrauterine growth restriction. There was no mortality or morbidity in both mothers and newborns. Conclusion Early-onset preeclampsia is a process of stress injuries directly caused by feta-placental ischemia, which could be monitored by measuring the umbilical blood velocity by Doppler Ultrasound. Continuous use of magnesium sulfate may better maternal and prenatal outcomes by dilating placental blood vessels and increasing the umbilical blood.
- Published
- 2015
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