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1,153 results on '"EVAN, ANDREW P."'

101. Apical membrane permeability of MDCK cells

Author

Rivers, Rickey L., McAteer, James A., Clendenon, Jeffrey L., Connors, Bret A., Evan, Andrew P., and Williams, James C., Jr.

Subjects
Cells -- Permeability, Permeability -- Physiological aspects, Cell junctions -- Physiological aspects, Biological sciences
Abstract

Apical membranes of Madin-Darby canine kidney (MDCK) cells have been shown to have a low permeability to water but their permeability to nonelectrolytes has not been investigated. In this study, it was shown that MDCK cells have a water-tight epithelial apical membrane. There were no differences in paracellular water flow among the cells. Membrane solute permeability was low, consistent with results for intact epithelial cells.

Published
1996

108. Why renal cysts grow

Author

Gardner, Kenneth D., Jr., Glew, Robert H., Evan, Andrew P., McAteer, James A., and Bernstein, Jay

Subjects
Kidney, Cystic -- Research, Saline water conversion -- Reverse osmosis process, Biological sciences
Abstract

Studies on renal cyst growth and development reveal that osmotic equilibration of water across cyst walls and the displacement of sodium by other solutes with osmotic activity are crucial components of the cyst growth process. Osmolytes in the lumina determine cyst volume. The mural cells proliferate and undergo necrosis in a process essential for cyst growth.

Published
1994

116. In Vivo Renal Tubule pH in Stone-Forming Human Kidneys

Author

Borofsky, Michael S., primary, Handa, Rajash K., additional, Evan, Andrew P., additional, Williams, James C., additional, Bledsoe, Sharon, additional, Coe, Fredric L., additional, Worcester, Elaine M., additional, and Lingeman, James E., additional

Published
2020
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117. A precision medicine approach uncovers a unique signature of neutrophils in patients with brushite kidney stones

Author

Makki, Mohammad Shahidul, primary, Winfree, Seth, additional, Lingeman, James E., additional, Witzmann, Frank, additional, Worcester, Elaine M., additional, Krambeck, Amy, additional, Coe, Fred, additional, Evan, Andrew P., additional, Bledsoe, Sharon, additional, Bergsland, Kristin, additional, Khochare, Suraj, additional, Barwinska, Daria, additional, Williams, James C., additional, and El-Achkar, Tarek M., additional

Published
2019
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122. Nondestructive analysis of urinary calculi using micro computed tomography

Author

Lingeman James E, Hatt Erin K, Kim Samuel C, Sommer Andre J, McAteer James A, Zarse Chad A, Evan Andrew P, and Williams James C

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Micro computed tomography (micro CT) has been shown to provide exceptionally high quality imaging of the fine structural detail within urinary calculi. We tested the idea that micro CT might also be used to identify the mineral composition of urinary stones non-destructively. Methods Micro CT x-ray attenuation values were measured for mineral that was positively identified by infrared microspectroscopy (FT-IR). To do this, human urinary stones were sectioned with a diamond wire saw. The cut surface was explored by FT-IR and regions of pure mineral were evaluated by micro CT to correlate x-ray attenuation values with mineral content. Additionally, intact stones were imaged with micro CT to visualize internal morphology and map the distribution of specific mineral components in 3-D. Results Micro CT images taken just beneath the cut surface of urinary stones showed excellent resolution of structural detail that could be correlated with structure visible in the optical image mode of FT-IR. Regions of pure mineral were not difficult to find by FT-IR for most stones and such regions could be localized on micro CT images of the cut surface. This was not true, however, for two brushite stones tested; in these, brushite was closely intermixed with calcium oxalate. Micro CT x-ray attenuation values were collected for six minerals that could be found in regions that appeared to be pure, including uric acid (3515 – 4995 micro CT attenuation units, AU), struvite (7242 – 7969 AU), cystine (8619 – 9921 AU), calcium oxalate dihydrate (13815 – 15797 AU), calcium oxalate monohydrate (16297 – 18449 AU), and hydroxyapatite (21144 – 23121 AU). These AU values did not overlap. Analysis of intact stones showed excellent resolution of structural detail and could discriminate multiple mineral types within heterogeneous stones. Conclusions Micro CT gives excellent structural detail of urinary stones, and these results demonstrate the feasibility of identifying and localizing most of the common mineral types found in urinary calculi using laboratory CT.

Published
2004
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136. Ed Carstensen, advisor and mentor to the shockwave lithotripsy program project group

Author

McAteer, James, primary, Evan, Andrew P., additional, Lingeman, James E., additional, Willis, Lynn R., additional, Blomgren, Philip M., additional, Williams, James C., additional, Handa, Rajash, additional, Connors, Bret A., additional, Crum, Lawrence, additional, Bailey, Michael, additional, Matula, Tom, additional, Khokhlova, Vera A., additional, Sapozhnikov, Oleg A., additional, Cleveland, Robin, additional, Colonius, Tim, additional, and Pishchalnikov, Yuri A., additional

Published
2017
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138. Ed Carstensen, advisor and mentor to the shockwave lithotripsy program project group

Author

McAteer, James, Evan, Andrew P., Lingeman, James E., Willis, Lynn R., Blomgren, Philip M., Williams, James C., Handa, Rajash, Connors, Bret A., Crum, Lawrence, Bailey, Michael, Matula, Tom, Khokhlova, Vera A., Sapozhnikov, Oleg A., Cleveland, Robin, Colonius, Tim, Pishchalnikov, Yuri A., McAteer, James, Evan, Andrew P., Lingeman, James E., Willis, Lynn R., Blomgren, Philip M., Williams, James C., Handa, Rajash, Connors, Bret A., Crum, Lawrence, Bailey, Michael, Matula, Tom, Khokhlova, Vera A., Sapozhnikov, Oleg A., Cleveland, Robin, Colonius, Tim, and Pishchalnikov, Yuri A.

Abstract

In the 1980s shockwave lithotripsy emerged as a revolutionary advancement for the treatment of kidney stones. Initial studies with patients showed SWL to be highly effective. The technology was elegant, outcomes exceptionally positive and early tests suggested treatment was safe. As experience with SWL grew, limitations surfaced. A key finding was that SWs have the potential to induce significant trauma to the kidney. Our group convinced the NIH it was time to conduct a rigorous assessment to characterize the adverse effects of SWL and determine the mechanisms of SW action in stone breakage and tissue injury. The NIH Program Project Grant mechanism mandated we establish a panel of external advisors to help guide our work. We needed expertise in physical acoustics, cavitation and animal models of ultrasound exposure. We wanted a leading expert. We were extremely fortunate to land Ed Carstensen. Ed worked with us for nearly 15 years, well into our third renewal cycle. He was a brilliant scientist, a man dedicated to the highest standards of conduct in research. Ed taught us a great deal, he inspired by example and had an exceptional influence on our work and on the greater field of lithotripsy research.

Published
2017

146. CONTRASTING HISTOPATHOLOGY AND CRYSTAL DEPOSITS IN KIDNEYS OF IDIOPATHIC STONE FORMERS WHO PRODUCE HYDROXY APATITE, BRUSHITE, OR CALCIUM OXALATE STONES

Author

Evan, Andrew P, Lingeman, James E, Worcester, Elaine M, Sommer, Andre J, Phillips, Carrie L, Williams, James C, and Coe, Fredric L

Subjects
Adult, Calcium Phosphates, Male, Adolescent, Calcium Oxalate, X-Ray Microtomography, Middle Aged, Article, Kidney Calculi, Young Adult, Durapatite, Microscopy, Electron, Transmission, Humans, Female, Aged
Abstract

Our previous work has shown that stone formers who form calcium phosphate (CaP) stones that contain any brushite (BRSF) have a distinctive renal histopathology and surgical anatomy when compared with idiopathic calcium oxalate stone formers (ICSF). Here we report on another group of idiopathic CaP stone formers, those forming stone containing primarily hydroxyapatite, in order to clarify in what ways their pathology differs from BRSF and ICSF. Eleven hydroxyapatite stone formers (HASF) (2 males, 9 females) were studied using intra-operative digital photography and biopsy of papillary and cortical regions to measure tissue changes associated with stone formation. Our main finding is that HASF and BRSF differ significantly from each other and that both differ greatly from ICSF. Both BRSF and ICSF patients have significant levels of Randall's plaque compared with HASF. Intra-tubular deposit number is greater in HASF than BRSF and nonexistent in ICSF while deposit size is smaller in HASF than BRSF. Cortical pathology is distinctly greater in BRSF than HASF. Four attached stones were observed in HASF, three in 25 BRSF and 5-10 per ICSF patient. HASF and BRSF differ clinically in that both have higher average urine pH, supersaturation of CaP, and calcium excretion than ICSF. Our work suggests that HASF and BRSF are two distinct and separate diseases and both differ greatly from ICSF.

Published
2014

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