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105. The Amazonian mangrove systems accumulate and release dissolved neodymium and hafnium to the oceans

Author

Antao Xu, Ed Hathorne, Michael Seidel, Te Liu, Nils E. Asp, Andrea Koschinsky, Thorsten Dittmar, and Martin Frank

Subjects
Geology, QE1-996.5, Environmental sciences, GE1-350
Abstract

Abstract Mangroves are essential tropical ecosystems nurturing a wide range of marine biodiversity and counteracting global warming by sequestering atmospheric carbon dioxide. Hence, the export mechanisms and fluxes of particulate and dissolved organic carbon and trace elements from mangroves directly influence coastal productivity, the global carbon cycle and thus global climate, which are, however, not well constrained. Here we find consistent radiogenic neodymium and hafnium isotopic compositions of porewater, sedimentary iron-manganese oxyhydroxides and coastal seawater, suggesting that the Amazonian mangrove belt supplies trace elements through porewater discharge, dissolution of iron-manganese oxyhydroxides and their interactions with seawater. Together, these processes supply 8.4 × 106 g yr-1 dissolved neodymium, equivalent to 64% of the total sources of neodymium to the Amazonian coastal seawater. Globally, mangrove systems along the continental margins contribute 6–9% of the net neodymium input to the ocean, which is similar to the contributions from atmospheric deposition. A contribution of this magnitude is potentially also the case for other trace elements, given the strong correlations between neodymium and iron (Pearson r = 0.92), and manganese (r = 0.75) concentrations across the entire river-ocean section, emphasizing the crucial role of mangrove system inputs in micro-nutrient cycling.

Published
2025
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106. Sesquinary catenae on the Martian satellite Phobos from reaccretion of escaping ejecta

Author

M. Nayak and E. Asphaug

Subjects
Science
Abstract

The origin of the numerous linear grooves and craters that litter the Martian moon Phobos' surface remains enigmatic. Here, by modelling low-velocity escaping ejecta from impacts to Phobos, the authors show that several of these chains can be explained by reimpacting sesquinary ejecta shortly after ejection.

Published
2016
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108. Recent electron cyclotron emission results on TCV

Author

Ch. Schlatter, Timothy Goodman, B. P. Duval, Victor Udintsev, P. Blanchard, A. Gudozhnik, Ph. Marmillod, Francesca Turco, M. A. Henderson, Olivier Sauter, L. Porte, E. Asp, H. Weisen, I. Klimanov, H. Shidara, M. Goniche, G. Turri, A. Mueck, X. Llobet, P. F. Isoz, G. Giruzzi, Stefano Coda, and E. Fable

Subjects
Physics, Nuclear and High Energy Physics, 020209 energy, Mechanical Engineering, Cyclotron, Magnetic confinement fusion, 02 engineering and technology, Electron, Tore Supra, 01 natural sciences, 010305 fluids & plasmas, law.invention, Nuclear Energy and Engineering, Physics::Plasma Physics, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Electron temperature, General Materials Science, Microturbulence, Tokamak à configuration variable, Atomic physics, Magnetohydrodynamics, Civil and Structural Engineering
Abstract

Electron cyclotron emission (ECE) diagnostics on Tokamak a Configuration Variable (TCV) allow study of the electron temperature evolution in time with good spatial and temporal resolution at the high field side and low field side at various lines of sight. That is why ECE is being widely used to obtain both qualitative and quantitative information on heat transport, magnetohydrodynamics (MHD) phenomena, and fast electron dynamics. In this paper, a new regime on TCV with regular oscillations of the electron temperature in electron cyclotron current drive (ECCD) driven fully noninductive discharges and in discharges with a combination of ohmic/ECCD driven current is discussed These oscillations are reminiscent of the oscillations of the central electron temperature (O-regime) seen on Tore Supra in fully noninductive lower hybrid current drive plasmas. A link between evolutions of the electron temperature, the MHD modes, and the current density profile on TCV is considered In order to yield information on the properties of microturbulence of electrostatic and magnetic origin on TCV, a correlation ECE radiometer is currently under development. A technical description of the diagnostic is presented in this paper.

110. Mud in the surf: Nature at work in a Brazilian Bay

Author

Duncan M. FitzGerald, Rodolfo José Angulo, William J. Cleary, Antonio H. F. Klein, Nils E. Asp, Ilya V. Buynevich, and Eduardo Siegle

Subjects
Sand mining, geography, geography.geographical_feature_category, Time frame, Oceanography, Work (electrical), Coastal plain, General Earth and Planetary Sciences, Sediment, Bay, Geology, Natural (archaeology), Deposition (geology)
Abstract

Massive discharge of mud from coastal rivers is a well-documented phenomenon. However, in areas with limited historical and instrumental records it is often difficult to assess the nature and history of the process. This article looks at Tijucas Bay, in southern Brazil (Figure 1a) (an area that was the landfall region in March 2004 for South America's first recorded hurricane [Bossack, 2004]), to examine the time frame for extensive deposition of fluid muds in the nearshore (Figure 1b). The new geological data suggest that whereas recent human activities (e.g., massive sand mining) along the Tijucas River may be important in increasing the suspended sediment discharge, the shift to a mud-dominated regime was part of the natural evolution of this coastal plain.

111. Current density evolution in electron internal transport barrier discharges in TCV

Author

E. Asp, Stefano Coda, Olivier Sauter, E. Fable, M. A. Henderson, Timothy Goodman, and C. Zucca

Subjects
Materials science, Tokamak, Physics, Plasma, Electron, Cyclotron Current Drive, Condensed Matter Physics, Electron transport chain, law.invention, Shear (sheet metal), Nuclear Energy and Engineering, law, Plasmas, Atomic physics, Current (fluid), Tokamak à configuration variable, Equilibria, Current density, Operation
Abstract

Simulations of the plasma current density evolution in electron internal transport barrier discharges on the Tokamak a Configuration Variable (TCV) have been performed, in order to determine the relationship between the safety-factor profile and the electron transport improvement. The results show that the formation of the transport barrier is correlated with the shear reversal in all cases studied, regardless of the different heating and current drive schemes. No indications were found of discrete effects related to low-order rational q surfaces. On the contrary, the increase in confinement along with the negative shear is gradual, but constant, indicating that the transition is smooth, although it can be very fast.

112. Overview of JET results

Author

F. Romanelli, F. Laxaback, I. Abel, V. Afanesyev, G. Agarici, K. M. Aggarwal, M. Airila, R. Akers, T.h. Alarcon, A. Alexeev, A. Alfier, P. Allan, S. Almaviva, A. Alonso, M. Alonso, B. Alper, H. Altmann, D. Alves, V. Amosov, G. Anda, F. Andersson, E. Andersson Sund́en, V. Andreev, Y. Andrew, M. Angelone, M. Anghel, A. Anghel, C. Angioni, G. Apruzzese, N. Arcis, P. Arena, A. Argouarch, M. Ariola, A. Armitano, R. Armstrong, G. Arnoux, S. Arshad, G. Artaserse, J. F. Artaud, A. Ash, E. Asp, O. Asunta, C. V. Atanasiu, G. Atkins, M. D. Axton, C. Ayres, A. Baciero, V. Bailescu, B. Baiocchi, R. A. Baker, I. Balboa, C. Balorin, N. Balshaw, J. W. Banks, Y. F. Baranov, D. Barbier, I. L. Barlow, M. A. Barnard, R. Barnsley, L. Barrena, L. Barrera, M. Baruzzo, V. Basiuk, G. Bateman, P. Batistoni, N. Baumgarten, L. Baylor, B. Bazylev, P. S. Beaumont, K. Beausang, M. B́ecoulet, N. Bekris, M. Beldishevski, A. C. Bell, F. Belli, M. Bellinger, P. S. A. Belo, ́.E. Belonohy, P. E. Bennett, N. A. Benterman, G. Berger By, H. Bergsåker, H. Berk, J. Bernardo, B. Bertrand, M. N. A. Beurskens, B. Bieg, B. Bienkowska, T. Biewer, T. M. Biewer, M. Bigi, R. Bilato, J. Bird, J. Bizarro, T. R. Blackman, P. Blanchard, E. Blanco, J. Blum, V. Bobkov, A. Boboc, D. Boilson, I. Bolshakova, T. Bolzonella, L. Boncagni, G. Bonheure, X. Bonnin, D. Borba, A. Borthwick, A. Botrugno, C. Boulbe, F. Bouquey, C. Bourdelle, K. v. Bovert, M. Bowden, T. Boyce, H. J. Boyer, A. Bozhenkov, R. J. Brade, J. M. A. Bradshaw, J. Braet, V. Braic, G. C. Braithwaite, C. Brault, H. Braune, B. Breizman, S. Bremond, P. D. Brennan, A. Brett, J. Breue, S. Brezinsek, M. D. J. Bright, F. Briscoe, M. Brix, M. Brombin, B. C. Brown, D. P. D. Brown, A. Bruschi, J. Brzozowski, J. Bucalossi, M. A. Buckley, T. Budd, R. Budny, R. V. Budny, P. Bunting, P. Buratti, G. Burcea, P. R. Butcher, R. J. Buttery, R. Caç̃ao, G. Calabr`o, C. P. Callaghan, J. P. Caminade, P. G. Camp, D. C. Campling, J. Canik, B. Cannas, A. J. Capel, P. J. Card, A. Cardinali, T. Carlstrom, P. Carman, D. Carralero, L. Carraro, T. Carter, B. B. Carvalho, P. Carvalho, A. Casati, C. Castaldo, J. Caughman, R. Cavazzana, M. Cavinato, M. Cecconello, F. E. Cecil, A. Cenedese, C. Centioli, R. Cesario, C. D. Challis, M. Chandler, C. Chang, A. Chankin, I. T. Chapman, D. J. Child, P. Chiru, G. Chitarin, I. Chugonov, I. Chugunov, D. Ciric, F. Clairet, R. H. Clarke, R. Clay, M. Clever, J. P. Coad, P. A. Coates, V. Cocilovo, S. Coda, R. Coelho, J. Coenen, I. Coffey, L. Colas, M. Cole, S. Collins, S. Combs, J. Compan, J. E. Conboy, S. Conroy, N. Cook, S. P. Cook, D. Coombs, S. R. Cooper, Y. Corre, G. Corrigan, S. Cortes, D. Coster, G. F. Counsell, X. Courtois, M. Cox, T. Craciunescu, S. Cramp, F. Crisanti, O. Croft, K. Crombe, B. J. Crowley, N. Cruz, L. Cupido, M. Curuia, R. A. Cusack, A. Czarnecka, S. Dalley, E. T. Daly, A. Dalziel, D. Darrow, O. David, N. Davies, J. J. Davis, I. E. Day, C. Day, R. De Angelis, G. deArcas, M. R. de Baar, E. delaCal, E. de la Luna, J. L. de Pablos, G. De Temmerman, P. C. de Vries, F. Degli Agostini, E. Delabie, D. del Castillo Negrete, L. Delpech, G. Denisov, A. J. Denyer, R. F. Denyer, S. Devaux, P. Devynck, L. Di Matteo, L. DiPace, P. J. Dirken, A. Dnestrovskiy, D. Dodt, K. Dominiczak, S. E. Dorling, D. Douai, A. P. Down, P. T. Doyle, J. R. Drake, T. Dreischuh, V. Drozdov, P. Dumortier, D. Dunai, I. Duran, F. Durodíe, K. Dylst, R. Eaton, T. Edlington, A. M. Edwards, D. T. Edwards, P. K. Edwards, T.h. Eich, A. Ekedahl, T. Elevant, A. Elfimov, B. Ellingboe, C. G. Elsmore, B. Emmoth, G. Ericsson, L. G. Eriksson, A. Eriksson, B. Esposito, H. G. Esser, T. Estrada, E. A. Evangelidis, G. E. Evans, G. D. Ewart, D. T. Ewers, G. Falchetto, D. Falie, J. G. A. Fanthome, D. Farina, J. W. Farthing, A. Fasoli, B. Faugeras, N. Fedorczak, R. C. Felton, C. Fenzi, H. Fernandes, J. A. Ferreira, J. Ferreira, J. Ferron, J. A. Fessey, L. Figini, A. Figueiredo, J. Figueiredo, P. Finburg, K. H. Finken, U. Fischer, N. Fitzgerald, J. Flanagan, C. Fleming, A. Fonseca, A. D. Forbes, O. Ford, A. Formisano, D. Fraboulet, R. J. Francis, L. Frassinetti, R. Fresa, J. P. Friconneau, D. Frigione, J. C. Fuchs, K. Fullard, W. Fundamenski, M. Furno Palumbo, J. Gafert, K. Ǵal, R. Galṽao, S. Garavaglia, X. Garbet, J. Garcia, M. Gar cia Munoz, W. Gardner, P. Garibaldi, D. Garnier, L. Garzotti, M. Gatu Johnson, P. Gaudio, E. Gauthier, J. W. Gaze, D. F. Gear, J. Gedney, S. J. Gee, M. Gelfusa, E. Genangeli, S. Gerasimov, A. Geraud, T. Gerbaud, M. Gherendi, N. Ghirelli, J. C. Giacalone, L. Giacomelli, C. S. Gibson, C. Gil, S. J. Gilligan, C. G. Gimblett, D. Gin, E. Giovannozzi, C. Giroud, G. Giruzzi, S. Glowacz, J. Godwin, J. K. Goff, P. Gohil, V. Goloborod’ko, B. Gonçalves, M. Goniche, S. Gonzales, S. M. Gonźalezde Vicente, A. Goodyear, N. Gorelenkov, G. Gorini, R. Goulding, B. Graham, D. Graham, M. E. Graham, G. Granucci, J. Graves, N. R. Green, H. Greuner, E. Grigore, F. S. Griph, C. Grisolia, G. Gros, G. Grossetti, M. Groth, S. Gr̈unhagen, M. P. Gryaznevich, R. Guirlet, B. Gulejova, J. Gunn, A. Gupta, P. Guzdar, P. Hacek, L. J. Hackett, S. Hacquin, B. Haist, A. Hakola, S. J. Hall, S. P. HallworthCook, D. T. Hamilton, H. Han, R. C. Handley, S. Harding, J. D. W. Harling, D. Harting, M. J. Harvey, T. D. V. Haupt, E. Havlickova, N. C. Hawkes, R. Hawryluk, J. H. Hay, N. Hayashi, P. W. Haydon, I. R. Hayward, S. Hazel, P. J. L. Heesterman, W. Heidbrink, J. Heikkinen, C. Hellesen, T. Hellsten, O. N. Hemming, T. C. Hender, M. Henderson, C. Hennig, V. Hennion, C. Hidalgo, S. Higashijima, J. W. Hill, M. Hill, K. Hill, J. Hillairet, D. Hillis, T. Hirai, M. Hitchin, J. Hobirk, C. Hogan, C. H. A. Hogben, G. M. D. Hogeweij, I. C. Hollingham, R. Holyaka, D. A. Homfray, G. Honeyands, S. H. Hong, C. Hopf, B. A. Horn, A. R. Horton, L. D. Horton, S. P. Hotchin, M. R. Hough, W. Houlberg, D. F. Howell, M. Hron, A. Huber, T. M. Huddleston, Z. Hudson, M. Hughes, M. Ḧuhnerbein, C. C. Hume, A. J. Hunt, C. L. Hunter, T. S. Hutchinson, S. Huygen, G. Huysmans, V. Hyn̈onen, S. Ide, R. Igreja, C. Illescas, F. Imbeaux, D. Ivanova, E. Ivings, S. Jachmich, G. Jackson, P. Jacquet, K. Jakubowska, M. Jakubowski, P. V. James, R. J. E. Jaspers, S. Jednorog, I. Jenkins, M. A. C. Jennison, C. Jeskins, O. Jin Kwon, E. Joffrin, M. F. Johnson, R. Johnson, T. Johnson, D. Jolovic, V. Jonauskas, E. M. Jones, G. Jones, H. D. Jones, T. T. C. Jones, M. Jouvet, C. Juṕen, I. Kachtchouk, J. Kaczmarczyk, A. Kallenbach, J. K̈allne, D. Kalupin, S. Ḱalvin, G. Kamelander, R. Kamendje, A. Kappatou, S. Karttunen, W. Kasparek, I. Katramados, M. Kaufmann, G. Kaveney, A. S. Kaye, M. J. Kear, D. L. Keeling, D. Kelliher, M. Kempenaars, P. Khilar, N. G. Kidd, M. Kiisk, K. M. Kim, R. F. King, D. J. Kinna, V. Kiptily, G. Kirnev, N. Kirneva, K. Kirov, A. Kirschner, R. Kisielius, D. Kislov, G. Kiss, T. Kiviniemi, G. Kizane, A. Klein, A. Klix, M. Knaup, K. Kneuper, H. Kneupner, P. J. Knight, S. J. Knipe, M. Kocan, F. K̈ochl, G. Kocsis, C. Konz, T. Koppitz, A. Korotkov, H. R. Koslowski, V. Kotov, M. D. Kovari, K. Kovarik, G. Kramer, A. Krasilnikov, V. Krasilnikov, S. Kraus, A. Kreter, K. Krieger, A. Kritz, Y. Krivchenkov, U. Kruezi, M. Krychowiak, S. Krylov, I. Ksiazek, M. Kubic, S. Kuhn, W. K̈uhnlein, T. Kurki Suonio, A. Kurowski, B. Kuteev, A. Kuyanov, R. La Haye, M. Laan, C. Labate, A. Lachichi, N. Lam, P. Lang, M. T. Large, I. Lassiwe, J. R. Last, K. D. Lawson, M. Laxåback, R. A. Layne, E. Lazzaro, F. LeGuern, B. LeBlanc, H. J. Leggate, M. Lehnen, M. Leigheb, I. Lengar, M. Lennholm, E. Lerche, C. N. Lescure, Y. Li, A. Li Puma, Y. Liang, J. Likonen, Y. Lin, J. Linke, S. A. Linstead, B. Lipshultz, X. Litaudon, A. G. Litvak, Y. Liu, T. Loarer, A. Loarte, R. C. Lobel, P. J. Lomas, F. D. Long, J. L̈onnroth, D. J. Looker, J. Lopez, P.h. Lotte, M. J. Loughlin, A. B. Loving, C. Lowry, T. Luce, R. M. A. Lucock, A. Lukanitsa, A. M. Lungu, C. P. Lungu, A. Lyssoivan, P. Macheta, A. S. Mackenzie, M. Macrae, G. Maddaluno, G. P. Maddison, J. Madsen, P. Maget, C. Maggi, H. Maier, J. Mailloux, M. Makowski, C. J. Manning, M. Mansfield, M. E. Manso, P. Mantica, M. Mantsinen, M. Maraschek, C. Marchetto, M. A. Marchitti, M. Mardenfeld, J. L. Marechal, M. Marinelli, A. Marinoni, M. Marinucci, J. M̈arki, D. Marocco, C. A. Marren, D. Martin, D. L. Martin, G. Martin, Y. Martin, J. R. Mart́ın Soĺıs, K. Masaki, A. Masiello, M. Maslov, C. Maszl, A. Matilal, M. Mattei, G. F. Matthews, F. Maviglia, C. R. May, M. Mayer, M. L. Mayoral, D. Mazon, C. Mazzotta, E. Mazzucato, P. McCarthy, K. G. McClements, K. McCormick, P. A. McCullen, D. McCune, D. C. McDonald, R. Mcgregor, J. P. Mckivitt, A. Meakins, F. Medina, A. G. Meigs, M. Menard, L. Meneses, S. Menmuir, I. R. Merrigan, P.h. Mertens, A. Messiaen, H. Meyer, M. Miele, P. Migliucci, A. G. Miller, S. F. Mills, J. J. Milnes, K. Min Kim, T. Mindham, F. Mirizzi, E. Mirones, M. Mironov, R. Mitteau, J. Mlynar, P. Mollard, I. Monakhov, P. Monier Garbet, R. Mooney, S. Moradi, D. Moreau, P.h. Moreau, L. Moreira, A. Morgan, P. D. Morgan, C. Morlock, A. Moro, A. W. Morris, G. L. Mort, C. Mrozek, A. Mueck, H. W. M̈uller, M. Murakami, A. Murari, I. Mustata, F. Nabais, E. Nardon, G. Nash, V. Naulin, M. F. F. Nave, R. Nazikian, I. Nedzelski, C. R. Negus, J. D. Neilson, A. Neto, R. Neu, O. Neubauer, G. J. Newbert, M. Newman, K. J. Nicholls, A. Nicolai, L. Nicolas, P. Nieckchen, P. Nielsen, A. H. Nielsen, S. K. Nielsen, G. Nielson, J. Nieto, M. P. S. Nightingale, C. Noble, M. Nocente, M. Nora, H. Nordman, M. Norman, J. M. Noterdaeme, S. Nowak, I. Nunes, F. Ognissanto, T. O’Gorman, S. Olariu, A. Oleynikov, M. O’Mullane, J. Ongena, F. Orsitto, O. I. Oswuigwe, M. Ottaviani, N. Oyama, D. Pacella, K. Paget, S. Palazzo, J. Pamela, S. Pamela, R. Panek, L. Pangione, A. Panin, T.h. Panis, A. Pankin, A. Pantea, V. Parail, T.h. Parisot, A. Parkin, A. Parsloe, B. T. Parsons, R. Pasqualotto, P. Pastor, R. Paterson, M. K. Paul, D. Peach, R. J. H. Pearce, B. J. Pearson, I. J. Pearson, L. C. Pedrick, M. A. Pedrosa, B. Pegourie, R. Pereira, E. Perelli Cippo, G. Pereverzev, A. Perevezentsev, C.h. PerezvonThun, V. Pericoli Ridolfini, A. Perona, Y. Perrot, S. Peruzzo, S. Peschanyy, G. Petravich, L. Petrizzi, V. Petrov, V. Petrzilka, V. Philipps, G. Piazza, F. Piccolo, A. Pietropaolo, M. Pillon, S. D. Pinches, T. Pinna, G. Pintsuk, P. Piovesan, F. Pisano, R. Pitts, B. Plaum, V. Plyusnin, M. Polasik, F. M. Poli, N. Pomaro, O. Pompilian, L. Poncet, P. J. Pool, S. Popovichev, F. Porcelli, M. T. Porfiri, C. Portafaix, A. Pospieszczyk, G. Possnert, G. Prestopino, P. Prior, R. Prokopowicz, I. Proverbio, R. Pugno, M. E. Puiatti, K. Purahoo, V. Pustovitov, T.h. P̈utterich, D. P̈uttmann Kneupner, E. Rachlew, R. Rademaker, T. Rafiq, M. S. J. Rainford, G. Ramogida, K. Rantam̈aki, J. Rapp, J. J. Rasmussen, G. Ratt́a, G. Ravera, M. Reich, R. Reichle, D. Reiser, R. Reiss, D. Reiter, D. Rendell, C. Reux, G. Rewoldt, T. T. Ribeiro, V. Riccardo, D. Richards, F. Rigollet, F. G. Rimini, L. Rios, M. Riva, J. E. C. Roberts, R. J. Robins, D. S. Robinson, S. A. Robinson, D. W. Robson, H. Roche, M. R̈odig, N. Rodionov, V. Rohde, A. Rolfe, M. Romanelli, A. Romano, J. Romero, E. Ronchi, S. Rosanvallon, C.h. Roux, S. Rowe, M. Rubel, L. Ruchko, M. Ruiz, C. Ruset, M. Russell, A. Ruth, L. Ryc, A. Rydzy, F. Ryter, J. Rzadkiewicz, S. Saarelma, F. Sabathier, R. Sabot, S. Sadakov, P. Sagar, G. Saibene, A. Saille, F. Saint Laurent, A. Salmi, R. Salomaa, F. Salzedas, U. Samm, P. Sanchez, S. Sanders, S. G. Sanders, G. Sandford, K. Sandland, P. Sandquist, D. E. G. Sands, M. I. K. Santala, F. Sartori, R. Sartori, O. Sauter, A. Savelyev, A. Savtchkov, S. C. Scales, A. Scarabosio, N. Schaefer, C.h. Schlatter, V. Schmidt, A. Schmidt, O. Schmitz, S. Schmuck, M. Schneider, M. Scholz, K. Scḧopf, B. Schweer, J. Schweinzer, B. Scott, M. Seki, L. Semeraro, A. Semerok, G. Sergienko, F. Serra, M. Sertoli, M. M. J. Shannon, S. E. Sharapov, S. R. Shaw, A. Shevelev, R. Sievering, C. A. Silva, P. A. Simmons, A. Simonetto, D. Simpson, S. Sipila, A. C. C. Sips, A. Sirinelli, H. Sj̈ostrand, D. Skopintsev, K. S.l.a.b.k.o.w.s.k.a., P. G. Smith, J. Snipes, L. Snoj, S. Snyder, S. Soare, E. R. Solano, S. Soldatov, A. Soleto, W. Solomon, C. Soltane, P. Sonato, A. Sopplesa, A. Sorrentino, J. Sousa, C. B. C. Sowden, C. Sozzi, P. Sp̈ah, T. Spelzini, J. Spence, F. Spineanu, P. Spuig, A. Sẗabler, R. D. Stagg, M. F. Stamp, V. Stancalie, P. Stangeby, C. Stan Sion, D. E. Starkey, M. J. Stead, A. V. Stephen, A. L. Stevens, J. Stober, R. B. Stokes, D. Stork, D. Stoyanov, J. Strachan, P. Strand, M. Stransky, D. Strauss, D. Strintzi, W. Studholme, Y. SuNa, F. Subba, H. P. Summers, Y. Sun, C. Surdu Bob, E. Surrey, D. J. Sutton, J. Svensson, D. Swain, B. D. Syme, I. D. Symonds, T. Szepesi, A. Szydlowski, F. Tabares, V. Takalo, H. Takenaga, T. Tala, A. R. Talbot, C. Taliercio, C. Tame, G. Tardini, M. Tardocchi, L. Taroni, G. Telesca, A. Terra, A. O. Terrington, D. Testa, J. M. Theis, J. D. Thomas, P. D. Thomas, P. R. Thomas, V. K. Thompson, H. Thomsen, C. Thomser, A. Thyagaraja, P. A. Tigwell, I. Tiseanu, R. Tivey, J. M. Todd, T. N. Todd, M. Z. Tokar, S. Tosti, P. Trabuc, J. M. Travere, W. Treutterer, P. Trimble, A. Trkov, E. Trukhina, M. Tsalas, H. Tsige Tamirat, E. Tsitrone, D. Tskhakaya jun, O. Tudisco, S. Tugarinov, M. M. Turner, G. Turri, S. G. J. Tyrrell, N. Umeda, B. Unterberg, H. Urano, A. J. Urquhart, I. Uytdenhouwen, A. Vaccaro, A. P. Vadgama, G. Vagliasindi, D. Valcarcel, M. Valisa, J. Vallory, M. Valovic, D. Van Eester, B. van Milligen, G. J. van Rooij, C. A. F. Varandas, S. Vartanian, V. Vdovin, J. Vega, G. Verdoolaege, J. M. Verger, L. Vermare, C. Verona, T.h. Versloot, M. Vervier, J. Vicente, S. Villari, E. Villedieu, F. Villone, J. E. Vince, G. J. Vine, B. Viola, E. Vitale, R. Vitelli, M. Vlad, I. Voitsekhovitch, M. Vrancken, K. Vulliez, C. W. F. Waldon, M. Walker, M. J. Walsh, J. Waterhouse, M. L. Watkins, M. J. Watson, T. Wauters, M. W. Way, C. R. Webb, J. Weiland, H. Weisen, M. Weiszflog, R. Wenninger, A. T. West, J. M. Weulersse, B. Weyssow, M. R. Wheatley, A. D. Whiteford, A. M. Whitehead, A. G. Whitehurst, A. M. Widdowson, R. C. Wieggers, C. Wiegmann, S. Wiesen, A. Wilson, D. Wilson, D. J. Wilson, H. R. Wilson, M. Wischmeier, D. M. Witts, R. C. Wolf, J. Wolowski, P. Woscov, G. M. Wright, J. Wright, G. S. Xu, V. Yavorskij, V. Yerashok, J. Yorkshades, C. Young, D. Young, I. D. Young, X. Yuhong, L. Zabeo, A. Zabolotsky, L. Zaccarian, R. Zagorski, F. S. Zaitsev, S. Zajac, L. Zakharov, R. Zanino, V. Zaroschi, K. D. Zastrow, I. Zatz, B. Zefran, W. Zeidner, M. Zerbini, T. Zhang, Y. Zhu, E. Zilli, O. Zimmermann, V. Zoita, S. Zoletnik, W. Zwingman, JET EFDA Contributors, ALBANESE, Raffaele, AMBROSINO, GIUSEPPE, BELLIZIO, TERESA, CARANNANTE, GIUSEPPE, COCCORESE, VINCENZO, DE TOMMASI, GIANMARIA, MIANO, GIOVANNI, PIRONTI, ALFREDO, QUERCIA, ANTONIO, RUBINACCI, GUGLIELMO, J., Pamela, EMILIA R., Solano, AND JET EFDA, Contributor, J. M., Adam, G., Agarici, M., Agarici, H., Akhter, Albanese, Raffaele, Romanelli, F., Laxaback, F., Abel, I., Afanesyev, V., Agarici, G., Aggarwal, K. M., Airila, M., Akers, R., Alarcon, T. h., Alexeev, A., Alfier, A., Allan, P., Almaviva, S., Alonso, A., Alonso, M., Alper, B., Altmann, H., Alves, D., Ambrosino, Giuseppe, Amosov, V., Anda, G., Andersson, F., Andersson Sund́en, E., Andreev, V., Andrew, Y., Angelone, M., Anghel, M., Anghel, A., Angioni, C., Apruzzese, G., Arcis, N., Arena, P., Argouarch, A., Ariola, M., Armitano, A., Armstrong, R., Arnoux, G., Arshad, S., Artaserse, G., Artaud, J. F., Ash, A., Asp, E., Asunta, O., Atanasiu, C. V., Atkins, G., Axton, M. D., Ayres, C., Baciero, A., Bailescu, V., Baiocchi, B., Baker, R. A., Balboa, I., Balorin, C., Balshaw, N., Banks, J. W., Baranov, Y. F., Barbier, D., Barlow, I. L., Barnard, M. A., Barnsley, R., Barrena, L., Barrera, L., Baruzzo, M., Basiuk, V., Bateman, G., Batistoni, P., Baumgarten, N., Baylor, L., Bazylev, B., Beaumont, P. S., Beausang, K., B́ecoulet, M., Bekris, N., Beldishevski, M., Bell, A. C., Belli, F., Bellinger, M., Bellizio, Teresa, Belo, P. S. A., Belonohy, ́. E., Bennett, P. E., Benterman, N. A., Berger By, G., Bergsåker, H., Berk, H., Bernardo, J., Bertrand, B., Beurskens, M. N. A., Bieg, B., Bienkowska, B., Biewer, T., Biewer, T. M., Bigi, M., Bilato, R., Bird, J., Bizarro, J., Blackman, T. R., Blanchard, P., Blanco, E., Blum, J., Bobkov, V., Boboc, A., Boilson, D., Bolshakova, I., Bolzonella, T., Boncagni, L., Bonheure, G., Bonnin, X., Borba, D., Borthwick, A., Botrugno, A., Boulbe, C., Bouquey, F., Bourdelle, C., Bovert, K. v., Bowden, M., Boyce, T., Boyer, H. J., Bozhenkov, A., Brade, R. J., Bradshaw, J. M. A., Braet, J., Braic, V., Braithwaite, G. C., Brault, C., Braune, H., Breizman, B., Bremond, S., Brennan, P. D., Brett, A., Breue, J., Brezinsek, S., Bright, M. D. J., Briscoe, F., Brix, M., Brombin, M., Brown, B. C., Brown, D. P. D., Bruschi, A., Brzozowski, J., Bucalossi, J., Buckley, M. A., Budd, T., Budny, R., Budny, R. V., Bunting, P., Buratti, P., Burcea, G., Butcher, P. R., Buttery, R. J., Caç̃ao, R., Calabr`o, G., Callaghan, C. P., Caminade, J. P., Camp, P. G., Campling, D. C., Canik, J., Cannas, B., Capel, A. J., Carannante, Giuseppe, Card, P. J., Cardinali, A., Carlstrom, T., Carman, P., Carralero, D., Carraro, L., Carter, T., Carvalho, B. B., Carvalho, P., Casati, A., Castaldo, C., Caughman, J., Cavazzana, R., Cavinato, M., Cecconello, M., Cecil, F. E., Cenedese, A., Centioli, C., Cesario, R., Challis, C. D., Chandler, M., Chang, C., Chankin, A., Chapman, I. T., Child, D. J., Chiru, P., Chitarin, G., Chugonov, I., Chugunov, I., Ciric, D., Clairet, F., Clarke, R. H., Clay, R., Clever, M., Coad, J. P., Coates, P. A., Coccorese, Vincenzo, Cocilovo, V., Coda, S., Coelho, R., Coenen, J., Coffey, I., Colas, L., Cole, M., Collins, S., Combs, S., Compan, J., Conboy, J. E., Conroy, S., Cook, N., Cook, S. P., Coombs, D., Cooper, S. R., Corre, Y., Corrigan, G., Cortes, S., Coster, D., Counsell, G. F., Courtois, X., Cox, M., Craciunescu, T., Cramp, S., Crisanti, F., Croft, O., Crombe, K., Crowley, B. J., Cruz, N., Cupido, L., Curuia, M., Cusack, R. A., Czarnecka, A., Dalley, S., Daly, E. T., Dalziel, A., Darrow, D., David, O., Davies, N., Davis, J. J., Day, I. E., Day, C., De Angelis, R., Dearcas, G., de Baar, M. R., Delacal, E., de la Luna, E., de Pablos, J. L., De Temmerman, G., DE TOMMASI, Gianmaria, de Vries, P. C., Degli Agostini, F., Delabie, E., del Castillo Negrete, D., Delpech, L., Denisov, G., Denyer, A. J., Denyer, R. F., Devaux, S., Devynck, P., Di Matteo, L., Dipace, L., Dirken, P. J., Dnestrovskiy, A., Dodt, D., Dominiczak, K., Dorling, S. E., Douai, D., Down, A. P., Doyle, P. T., Drake, J. R., Dreischuh, T., Drozdov, V., Dumortier, P., Dunai, D., Duran, I., Durodíe, F., Dylst, K., Eaton, R., Edlington, T., Edwards, A. M., Edwards, D. T., Edwards, P. K., Eich, T. h., Ekedahl, A., Elevant, T., Elfimov, A., Ellingboe, B., Elsmore, C. G., Emmoth, B., Ericsson, G., Eriksson, L. G., Eriksson, A., Esposito, B., Esser, H. G., Estrada, T., Evangelidis, E. A., Evans, G. E., Ewart, G. D., Ewers, D. T., Falchetto, G., Falie, D., Fanthome, J. G. A., Farina, D., Farthing, J. W., Fasoli, A., Faugeras, B., Fedorczak, N., Felton, R. C., Fenzi, C., Fernandes, H., Ferreira, J. A., Ferreira, J., Ferron, J., Fessey, J. A., Figini, L., Figueiredo, A., Figueiredo, J., Finburg, P., Finken, K. H., Fischer, U., Fitzgerald, N., Flanagan, J., Fleming, C., Fonseca, A., Forbes, A. D., Ford, O., Formisano, A., Fraboulet, D., Francis, R. J., Frassinetti, L., Fresa, R., Friconneau, J. P., Frigione, D., Fuchs, J. C., Fullard, K., Fundamenski, W., Furno Palumbo, M., Gafert, J., Ǵal, K., Galṽao, R., Garavaglia, S., Garbet, X., Garcia, J., Gar cia Munoz, M., Gardner, W., Garibaldi, P., Garnier, D., Garzotti, L., Gatu Johnson, M., Gaudio, P., Gauthier, E., Gaze, J. W., Gear, D. F., Gedney, J., Gee, S. J., Gelfusa, M., Genangeli, E., Gerasimov, S., Geraud, A., Gerbaud, T., Gherendi, M., Ghirelli, N., Giacalone, J. C., Giacomelli, L., Gibson, C. S., Gil, C., Gilligan, S. J., Gimblett, C. G., Gin, D., Giovannozzi, E., Giroud, C., Giruzzi, G., Glowacz, S., Godwin, J., Goff, J. K., Gohil, P., Goloborod’Ko, V., Gonçalves, B., Goniche, M., Gonzales, S., Gonźalezde Vicente, S. M., Goodyear, A., Gorelenkov, N., Gorini, G., Goulding, R., Graham, B., Graham, D., Graham, M. E., Granucci, G., Graves, J., Green, N. R., Greuner, H., Grigore, E., Griph, F. S., Grisolia, C., Gros, G., Grossetti, G., Groth, M., Gr̈unhagen, S., Gryaznevich, M. P., Guirlet, R., Gulejova, B., Gunn, J., Gupta, A., Guzdar, P., Hacek, P., Hackett, L. J., Hacquin, S., Haist, B., Hakola, A., Hall, S. J., Hallworthcook, S. P., Hamilton, D. T., Han, H., Handley, R. C., Harding, S., Harling, J. D. W., Harting, D., Harvey, M. J., Haupt, T. D. V., Havlickova, E., Hawkes, N. C., Hawryluk, R., Hay, J. H., Hayashi, N., Haydon, P. W., Hayward, I. R., Hazel, S., Heesterman, P. J. L., Heidbrink, W., Heikkinen, J., Hellesen, C., Hellsten, T., Hemming, O. N., Hender, T. C., Henderson, M., Hennig, C., Hennion, V., Hidalgo, C., Higashijima, S., Hill, J. W., Hill, M., Hill, K., Hillairet, J., Hillis, D., Hirai, T., Hitchin, M., Hobirk, J., Hogan, C., Hogben, C. H. A., Hogeweij, G. M. D., Hollingham, I. C., Holyaka, R., Homfray, D. A., Honeyands, G., Hong, S. H., Hopf, C., Horn, B. A., Horton, A. R., Horton, L. D., Hotchin, S. P., Hough, M. R., Houlberg, W., Howell, D. F., Hron, M., Huber, A., Huddleston, T. M., Hudson, Z., Hughes, M., Ḧuhnerbein, M., Hume, C. C., Hunt, A. J., Hunter, C. L., Hutchinson, T. S., Huygen, S., Huysmans, G., Hyn̈onen, V., Ide, S., Igreja, R., Illescas, C., Imbeaux, F., Ivanova, D., Ivings, E., Jachmich, S., Jackson, G., Jacquet, P., Jakubowska, K., Jakubowski, M., James, P. V., Jaspers, R. J. E., Jednorog, S., Jenkins, I., Jennison, M. A. C., Jeskins, C., Jin Kwon, O., Joffrin, E., Johnson, M. F., Johnson, R., Johnson, T., Jolovic, D., Jonauskas, V., Jones, E. M., Jones, G., Jones, H. D., Jones, T. T. C., Jouvet, M., Juṕen, C., Kachtchouk, I., Kaczmarczyk, J., Kallenbach, A., K̈allne, J., Kalupin, D., Ḱalvin, S., Kamelander, G., Kamendje, R., Kappatou, A., Karttunen, S., Kasparek, W., Katramados, I., Kaufmann, M., Kaveney, G., Kaye, A. S., Kear, M. J., Keeling, D. L., Kelliher, D., Kempenaars, M., Khilar, P., Kidd, N. G., Kiisk, M., Kim, K. M., King, R. F., Kinna, D. J., Kiptily, V., Kirnev, G., Kirneva, N., Kirov, K., Kirschner, A., Kisielius, R., Kislov, D., Kiss, G., Kiviniemi, T., Kizane, G., Klein, A., Klix, A., Knaup, M., Kneuper, K., Kneupner, H., Knight, P. J., Knipe, S. J., Kocan, M., K̈ochl, F., Kocsis, G., Konz, C., Koppitz, T., Korotkov, A., Koslowski, H. R., Kotov, V., Kovari, M. D., Kovarik, K., Kramer, G., Krasilnikov, A., Krasilnikov, V., Kraus, S., Kreter, A., Krieger, K., Kritz, A., Krivchenkov, Y., Kruezi, U., Krychowiak, M., Krylov, S., Ksiazek, I., Kubic, M., Kuhn, S., K̈uhnlein, W., Kurki Suonio, T., Kurowski, A., Kuteev, B., Kuyanov, A., La Haye, R., Laan, M., Labate, C., Lachichi, A., Lam, N., Lang, P., Large, M. T., Lassiwe, I., Last, J. R., Lawson, K. D., Laxåback, M., Layne, R. A., Lazzaro, E., Leguern, F., Leblanc, B., Leggate, H. J., Lehnen, M., Leigheb, M., Lengar, I., Lennholm, M., Lerche, E., Lescure, C. N., Li, Y., Li Puma, A., Liang, Y., Likonen, J., Lin, Y., Linke, J., Linstead, S. A., Lipshultz, B., Litaudon, X., Litvak, A. G., Liu, Y., Loarer, T., Loarte, A., Lobel, R. C., Lomas, P. J., Long, F. D., L̈onnroth, J., Looker, D. J., Lopez, J., Lotte, P. h., Loughlin, M. J., Loving, A. B., Lowry, C., Luce, T., Lucock, R. M. A., Lukanitsa, A., Lungu, A. M., Lungu, C. P., Lyssoivan, A., Macheta, P., Mackenzie, A. S., Macrae, M., Maddaluno, G., Maddison, G. P., Madsen, J., Maget, P., Maggi, C., Maier, H., Mailloux, J., Makowski, M., Manning, C. J., Mansfield, M., Manso, M. E., Mantica, P., Mantsinen, M., Maraschek, M., Marchetto, C., Marchitti, M. A., Mardenfeld, M., Marechal, J. L., Marinelli, M., Marinoni, A., Marinucci, M., M̈arki, J., Marocco, D., Marren, C. A., Martin, D., Martin, D. L., Martin, G., Martin, Y., Mart́ın Soĺıs, J. R., Masaki, K., Masiello, A., Maslov, M., Maszl, C., Matilal, A., Mattei, M., Matthews, G. F., Maviglia, F., May, C. R., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mazzucato, E., Mccarthy, P., Mcclements, K. G., Mccormick, K., Mccullen, P. A., Mccune, D., Mcdonald, D. C., Mcgregor, R., Mckivitt, J. P., Meakins, A., Medina, F., Meigs, A. G., Menard, M., Meneses, L., Menmuir, S., Merrigan, I. R., Mertens, P. h., Messiaen, A., Meyer, H., Miano, Giovanni, Miele, M., Migliucci, P., Miller, A. G., Mills, S. F., Milnes, J. J., Min Kim, K., Mindham, T., Mirizzi, F., Mirones, E., Mironov, M., Mitteau, R., Mlynar, J., Mollard, P., Monakhov, I., Monier Garbet, P., Mooney, R., Moradi, S., Moreau, D., Moreau, P. h., Moreira, L., Morgan, A., Morgan, P. D., Morlock, C., Moro, A., Morris, A. W., Mort, G. L., Mrozek, C., Mueck, A., M̈uller, H. W., Murakami, M., Murari, A., Mustata, I., Nabais, F., Nardon, E., Nash, G., Naulin, V., Nave, M. F. F., Nazikian, R., Nedzelski, I., Negus, C. R., Neilson, J. D., Neto, A., Neu, R., Neubauer, O., Newbert, G. J., Newman, M., Nicholls, K. J., Nicolai, A., Nicolas, L., Nieckchen, P., Nielsen, P., Nielsen, A. H., Nielsen, S. K., Nielson, G., Nieto, J., Nightingale, M. P. S., Noble, C., Nocente, M., Nora, M., Nordman, H., Norman, M., Noterdaeme, J. M., Nowak, S., Nunes, I., Ognissanto, F., O’Gorman, T., Olariu, S., Oleynikov, A., O’Mullane, M., Ongena, J., Orsitto, F., Oswuigwe, O. I., Ottaviani, M., Oyama, N., Pacella, D., Paget, K., Palazzo, S., Pamela, J., Pamela, S., Panek, R., Pangione, L., Panin, A., Panis, T. h., Pankin, A., Pantea, A., Parail, V., Parisot, T. h., Parkin, A., Parsloe, A., Parsons, B. T., Pasqualotto, R., Pastor, P., Paterson, R., Paul, M. K., Peach, D., Pearce, R. J. H., Pearson, B. J., Pearson, I. J., Pedrick, L. C., Pedrosa, M. A., Pegourie, B., Pereira, R., Perelli Cippo, E., Pereverzev, G., Perevezentsev, A., Perezvonthun, C. h., Pericoli Ridolfini, V., Perona, A., Perrot, Y., Peruzzo, S., Peschanyy, S., Petravich, G., Petrizzi, L., Petrov, V., Petrzilka, V., Philipps, V., Piazza, G., Piccolo, F., Pietropaolo, A., Pillon, M., Pinches, S. D., Pinna, T., Pintsuk, G., Piovesan, P., Pironti, Alfredo, Pisano, F., Pitts, R., Plaum, B., Plyusnin, V., Polasik, M., Poli, F. M., Pomaro, N., Pompilian, O., Poncet, L., Pool, P. J., Popovichev, S., Porcelli, F., Porfiri, M. T., Portafaix, C., Pospieszczyk, A., Possnert, G., Prestopino, G., Prior, P., Prokopowicz, R., Proverbio, I., Pugno, R., Puiatti, M. E., Purahoo, K., Pustovitov, V., P̈utterich, T. h., P̈uttmann Kneupner, D., Quercia, Antonio, Rachlew, E., Rademaker, R., Rafiq, T., Rainford, M. S. J., Ramogida, G., Rantam̈aki, K., Rapp, J., Rasmussen, J. J., Ratt́a, G., Ravera, G., Reich, M., Reichle, R., Reiser, D., Reiss, R., Reiter, D., Rendell, D., Reux, C., Rewoldt, G., Ribeiro, T. T., Riccardo, V., Richards, D., Rigollet, F., Rimini, F. G., Rios, L., Riva, M., Roberts, J. E. C., Robins, R. J., Robinson, D. S., Robinson, S. A., Robson, D. W., Roche, H., R̈odig, M., Rodionov, N., Rohde, V., Rolfe, A., Romanelli, M., Romano, A., Romero, J., Ronchi, E., Rosanvallon, S., Roux, C. h., Rowe, S., Rubel, M., Rubinacci, Guglielmo, Ruchko, L., Ruiz, M., Ruset, C., Russell, M., Ruth, A., Ryc, L., Rydzy, A., Ryter, F., Rzadkiewicz, J., Saarelma, S., Sabathier, F., Sabot, R., Sadakov, S., Sagar, P., Saibene, G., Saille, A., Saint Laurent, F., Salmi, A., Salomaa, R., Salzedas, F., Samm, U., Sanchez, P., Sanders, S., Sanders, S. G., Sandford, G., Sandland, K., Sandquist, P., Sands, D. E. G., Santala, M. I. K., Sartori, F., Sartori, R., Sauter, O., Savelyev, A., Savtchkov, A., Scales, S. C., Scarabosio, A., Schaefer, N., Schlatter, C. h., Schmidt, V., Schmidt, A., Schmitz, O., Schmuck, S., Schneider, M., Scholz, M., Scḧopf, K., Schweer, B., Schweinzer, J., Scott, B., Seki, M., Semeraro, L., Semerok, A., Sergienko, G., Serra, F., Sertoli, M., Shannon, M. M. J., Sharapov, S. E., Shaw, S. R., Shevelev, A., Sievering, R., Silva, C. A., Simmons, P. A., Simonetto, A., Simpson, D., Sipila, S., Sips, A. C. C., Sirinelli, A., Sj̈ostrand, H., Skopintsev, D., K. S. l. a. b. k. o. w. s. k. a., Smith, P. G., Snipes, J., Snoj, L., Snyder, S., Soare, S., Solano, E. R., Soldatov, S., Soleto, A., Solomon, W., Soltane, C., Sonato, P., Sopplesa, A., Sorrentino, A., Sousa, J., Sowden, C. B. C., Sozzi, C., Sp̈ah, P., Spelzini, T., Spence, J., Spineanu, F., Spuig, P., Sẗabler, A., Stagg, R. D., Stamp, M. F., Stancalie, V., Stangeby, P., Stan Sion, C., Starkey, D. E., Stead, M. J., Stephen, A. V., Stevens, A. L., Stober, J., Stokes, R. B., Stork, D., Stoyanov, D., Strachan, J., Strand, P., Stransky, M., Strauss, D., Strintzi, D., Studholme, W., Suna, Y., Subba, F., Summers, H. P., Sun, Y., Surdu Bob, C., Surrey, E., Sutton, D. J., Svensson, J., Swain, D., Syme, B. D., Symonds, I. D., Szepesi, T., Szydlowski, A., Tabares, F., Takalo, V., Takenaga, H., Tala, T., Talbot, A. R., Taliercio, C., Tame, C., Tardini, G., Tardocchi, M., Taroni, L., Telesca, G., Terra, A., Terrington, A. O., Testa, D., Theis, J. M., Thomas, J. D., Thomas, P. D., Thomas, P. R., Thompson, V. K., Thomsen, H., Thomser, C., Thyagaraja, A., Tigwell, P. A., Tiseanu, I., Tivey, R., Todd, J. M., Todd, T. N., Tokar, M. Z., Tosti, S., Trabuc, P., Travere, J. M., Treutterer, W., Trimble, P., Trkov, A., Trukhina, E., Tsalas, M., Tsige Tamirat, H., Tsitrone, E., Tskhakaya jun, D., Tudisco, O., Tugarinov, S., Turner, M. M., Turri, G., Tyrrell, S. G. J., Umeda, N., Unterberg, B., Urano, H., Urquhart, A. J., Uytdenhouwen, I., Vaccaro, A., Vadgama, A. P., Vagliasindi, G., Valcarcel, D., Valisa, M., Vallory, J., Valovic, M., Van Eester, D., van Milligen, B., van Rooij, G. J., Varandas, C. A. F., Vartanian, S., Vdovin, V., Vega, J., Verdoolaege, G., Verger, J. M., Vermare, L., Verona, C., Versloot, T. h., Vervier, M., Vicente, J., Villari, S., Villedieu, E., Villone, F., Vince, J. E., Vine, G. J., Viola, B., Vitale, E., Vitelli, R., Vlad, M., Voitsekhovitch, I., Vrancken, M., Vulliez, K., Waldon, C. W. F., Walker, M., Walsh, M. J., Waterhouse, J., Watkins, M. L., Watson, M. J., Wauters, T., Way, M. W., Webb, C. R., Weiland, J., Weisen, H., Weiszflog, M., Wenninger, R., West, A. T., Weulersse, J. M., Weyssow, B., Wheatley, M. R., Whiteford, A. D., Whitehead, A. M., Whitehurst, A. G., Widdowson, A. M., Wieggers, R. C., Wiegmann, C., Wiesen, S., Wilson, A., Wilson, D., Wilson, D. J., Wilson, H. R., Wischmeier, M., Witts, D. M., Wolf, R. C., Wolowski, J., Woscov, P., Wright, G. M., Wright, J., G. S., Xu, Yavorskij, V., Yerashok, V., Yorkshades, J., Young, C., Young, D., Young, I. D., Yuhong, X., Zabeo, L., Zabolotsky, A., Zaccarian, L., Zagorski, R., Zaitsev, F. S., Zajac, S., Zakharov, L., Zanino, R., Zaroschi, V., Zastrow, K. D., Zatz, I., Zefran, B., Zeidner, W., Zerbini, M., Zhang, T., Zhu, Y., Zilli, E., Zimmermann, O., Zoita, V., Zoletnik, S., Zwingman, W., JET EFDA Contributors, Romanelli, F, Laxaback, M, Abel, I, Afanesyev, V, Agarici, G, Aggarwal, K, Airila, M, Akers, R, Alarcon, T, Albanese, R, Alexeev, A, Alfier, A, Allan, P, Almaviva, S, Alonso, A, Alonso, M, Alper, B, Altmann, H, Alves, D, Ambrosino, G, Amosov, V, Anda, G, Andersson, F, Andersson Sunden, E, Andreev, V, Andrew, Y, Angelone, M, Anghel, M, Anghel, A, Angioni, C, Apruzzese, G, Arcis, N, Arena, P, Argouarch, A, Ariola, M, Armitano, A, Armstrong, R, Arnoux, G, Arshad, S, Artaserse, G, Artaud, J, Ash, A, Asp, E, Asunta, O, Atanasiu, C, Atkins, G, Axton, M, Ayres, C, Baciero, A, Bailescu, V, Baiocchi, B, Baker, R, Balboa, I, Balorin, C, Balshaw, N, Banks, J, Baranov, Y, Barbier, D, Barlow, I, Barnard, M, Barnsley, R, Barrena, L, Barrera, L, Baruzzo, M, Basiuk, V, Bateman, G, Batiston, P, Baumgarten, N, Baylor, L, Bazylev, B, Beaumont, P, Beausang, K, Becoulet, M, Bekris, N, Beldishevski, M, Bell, A, Belli, F, Bellinger, M, Bellizio, T, Belo, P, Belonohy, E, Bennett, P, Benterman, N, Berger By, G, Bergsaker, H, Berk, H, Bernardo, J, Bertrand, B, Beurskens, M, Bieg, B, Bienkowska, B, Biewer, T, Bigi, M, Bilato, R, Bird, J, Bizarro, J, Blackman, T, Blanchard, P, Blanco, E, Blum, J, Bobkov, V, Boboc, A, Boilson, D, Bolshakova, I, Bolzonella, T, Boncagni, L, Bonheure, G, Bonnin, X, Borba, D, Borthwick, A, Botrugno, A, Boulbe, C, Bouquey, F, Bourdelle, C, Bovert, K, Bowden, M, Boyce, T, Boyer, H, Bozhenkov, A, Brade, R, Bradshaw, J, Braet, J, Braic, V, Braithwaite, G, Brault, C, Braune, H, Breizman, B, Bremond, S, Brennan, P, Brett, A, Breue, J, Brezinsek, S, Bright, M, Briscoe, F, Brix, M, Brombin, M, Brown, B, Brown, D, Bruschi, A, Brzozowski, J, Bucalossi, J, Buckley, M, Budd, T, Budny, R, Bunting, P, Buratti, P, Burcea, G, Butcher, P, Buttery, R, Cacao, R, Calabro, G, Callaghan, C, Caminade, J, Camp, P, Campling, D, Canik, J, Cannas, B, Capel, A, Carannante, G, Card, P, Cardinali, A, Carlstrom, T, Carman, P, Carralero, D, Carraro, L, Carter, T, Carvalho, B, Carvalho, P, Casati, A, Castaldo, C, Caughman, J, Cavazzana, R, Cavinato, M, Cecconello, M, Cecil, F, Cenedese, A, Centioli, C, Cesario, R, Challis, C, Chandler, M, Chang, C, Chankin, A, Chapman, I, Child, D, Chiru, P, Chitarin, G, Chugonov, I, Ciric, D, Clairet, F, Clarke, R, Clay, R, Clever, M, Coad, J, Coates, P, Coccorese, V, Cocilovo, V, Coda, S, Coelho, R, Coenen, J, Coffey, I, Colas, L, Cole, M, Collins, S, Combs, S, Compan, J, Conboy, J, Conroy, S, Cook, N, Cook, S, Coombs, D, Cooper, S, Corre, Y, Corrigan, G, Cortes, S, Coster, D, Counsell, G, Courtois, X, Cox, M, Craciunescu, T, Cramp, S, Crisanti, F, Croft, O, Crombe, K, Crowley, B, Cruz, N, Cupido, L, Curuia, M, Cusack, R, Czarnecka, A, Dalley, S, Daly, E, Dalziel, A, Darrow, D, David, O, Davies, N, Davis, J, Day, I, Day, C, De Angelis, R, de Arcas, G, de Baar, M, de la Cal, E, de la Luna, E, de Pablos, J, De Temmerman, G, De Tommasi, G, de Vries, P, Degli Agostini, F, Delabie, E, del Castillo Negrete, D, Delpech, L, Denisov, G, Denyer, A, Denyer, R, Devaux, S, Devynck, P, Di Matteo, L, Di Pace, L, Dirken, P, Dnestrovskiy, A, Dodt, D, Dominiczak, K, Dorling, S, Douai, D, Down, A, Doyle, P, Drake, J, Dreischuh, T, Drozdov, V, Dumortier, P, Dunai, D, Duran, I, Durodie, F, Dylst, K, Eaton, R, Edlington, T, Edwards, A, Edwards, D, Edwards, P, Eich, T, Ekedahl, A, Elevant, T, Elfimov, A, Ellingboe, B, Elsmore, C, Emmoth, B, Ericsson, G, Eriksson, L, Eriksson, A, Esposito, B, Esser, H, Estrada, T, Evangelidis, E, Evans, G, Ewart, G, Ewers, D, Falchetto, G, Falie, D, Fanthome, J, Farina, D, Farthing, J, Fasoli, A, Faugeras, B, Fedorczak, N, Felton, R, Fenzi, C, Fernandes, H, Ferreira, J, Ferron, J, Fessey, J, Figini, L, Figueiredo, A, Figueiredo, J, Finburg, P, Finken, K, Fischer, U, Fitzgerald, N, Flanagan, J, Fleming, C, Fonseca, A, Forbes, A, Ford, O, Formisano, A, Fraboulet, D, Francis, R, Frassinetti, L, Fresa, R, Friconneau, J, Frigione, D, Fuchs, J, Fullard, K, Fundamenski, W, Furno Palumbo, M, Gafert, J, Gal, K, Galvao, R, Garavaglia, S, Garbet, X, Garcia, J, Garcia Munoz, M, Gardner, W, Garibaldi, P, Garnier, D, Garzotti, L, Gatu Johnson, M, Gaudio, P, Gauthier, E, Gaze, J, Gear, D, Gedney, J, Gee, S, Gelfusa, M, Genangeli, E, Gerasimov, S, Geraud, A, Gerbaud, T, Gherendi, M, Ghirelli, N, Giacalone, J, Giacomelli, L, Gibson, C, Gil, C, Gilligan, S, Gimblett, C, Gin, D, Giovannozzi, E, Giroud, C, Giruzzi, G, Glowacz, S, Godwin, J, Goff, J, Gohil, P, Goloborod'Ko, V, Goncalves, B, Goniche, M, Gonzales, S, Gonzales de Vicente, S, Goodyear, A, Gorelenkov, N, Gorini, G, Goulding, R, Graham, B, Graham, D, Graham, M, Granucci, G, Graves, J, Green, N, Greuner, H, Grigore, E, Griph, F, Grisolia, C, Gros, G, Grossetti, G, Groth, M, Gruenhagen, S, Gryaznevich, M, Guirlet, R, Gulejova, B, Gunn, J, Gupta, A, Guzdar, P, Hacek, P, Hackett, L, Hacquin, S, Haist, B, Hakola, A, Hall, S, Hallworth Cook, S, Hamilton, D, Han, H, Handley, R, Harding, S, Harling, J, Harting, D, Harvey, M, Haupt, T, Havlickova, E, Hawkes, N, Hawryluk, R, Hay, J, Hayashi, N, Haydon, P, Hayward, I, Hazel, S, Heesterman, P, Heidbrink, W, Heikkinen, J, Hellesen, C, Hellsten, T, Hemming, O, Hender, T, Henderson, M, Hennig, C, Hennion, V, Hidalgo, C, Higashijima, S, Hill, J, Hill, M, Hill, K, Hillairet, J, Hillis, D, Hirai, T, Hitchin, M, Hobirk, J, Hogan, C, Hogben, C, Hogeweij, G, Hollingham, I, Holyaka, R, Homfray, D, Honeyands, G, Hong, S, Hopf, C, Horn, B, Horton, A, Horton, L, Hotchin, S, Hough, M, Houlberg, W, Howell, D, Hron, M, Huber, A, Huddleston, T, Hudson, Z, Hughes, M, Huehnerbein, M, Hume, C, Hunt, A, Hunter, C, Hutchinson, T, Huygen, S, Huysmans, G, Hynoenen, V, Ide, S, Igreja, R, Illescas, C, Imbeaux, F, Ivanova, D, Ivings, E, Jachmich, S, Jackson, G, Jacquet, P, Jakubowska, K, Jakubowski, M, James, P, Jaspers, R, Jednorog, S, Jenkins, I, Jennison, M, Jeskins, C, Jin Kwon, O, Joffrin, E, Johnson, M, Johnson, R, Johnson, T, Jolovic, D, Jonauskas, V, Jones, E, Jones, G, Jones, H, Jones, T, Jouvet, M, Jupen, C, Kachtchouk, I, Kaczmarczyk, J, Kallenbach, A, Kaellne, J, Kalupin, D, Kalvin, S, Kamelander, G, Kamendje, R, Kappatou, A, Karttunen, S, Kasparek, W, Katramados, I, Kaufmann, M, Kaveney, G, Kaye, A, Kear, M, Keeling, D, Kelliher, D, Kempenaars, M, Khilar, P, Kidd, N, Kiisk, M, Kim, K, King, R, Kinna, D, Kiptily, V, Kirnev, G, Kirneva, N, Kirov, K, Kirschner, A, Kisielius, R, Kislov, D, Kiss, G, Kiviniemi, T, Kizane, G, Klein, A, Klix, A, Knaup, M, Kneuper, K, Kneupner, H, Knight, P, Knipe, S, Kocan, M, Koechl, F, Kocsis, G, Konz, C, Koppitz, T, Korotkov, A, Koslowski, H, Kotov, V, Kovari, M, Kovarik, K, Kramer, G, Krasilnikov, A, Krasilnikov, V, Kraus, S, Kreter, A, Krieger, K, Kritz, A, Krivchenkov, Y, Kruezi, U, Krychowiak, M, Krylov, S, Ksiazek, I, Kubic, M, Kuhn, S, Kuehnlein, W, Kurki Suonio, T, Kurowski, A, Kuteev, B, Kuyanov, A, La Haye, R, Laan, M, Labate, C, Lachichi, A, Lam, N, Lang, P, Large, M, Lassiwe, I, Last, J, Lawson, K, Layne, R, Lazzaro, E, Le Guern, F, Leblanc, B, Leggate, H, Lehnen, M, Leigheb, M, Lengar, I, Lennholm, M, Lerche, E, Lescure, C, Li, Y, Li Puma, A, Liang, Y, Likonen, J, Lin, Y, Linke, J, Linstead, S, Lipshultz, B, Litaudon, X, Litvak, A, Liu, Y, Loarer, T, Loarte, A, Lobel, R, Lomas, P, Long, F, Loennroth, J, Looker, D, Lopez, J, Lotte, P, Loughlin, M, Loving, A, Lowry, C, Luce, T, Lucock, R, Lukanitsa, A, Lungu, A, Lungu, C, Lyssoivan, A, Macheta, P, Mackenzie, A, Macrae, M, Maddaluno, G, Maddison, G, Madsen, J, Maget, P, Maggi, C, Maier, H, Mailloux, J, Makowski, M, Manning, C, Mansfield, M, Manso, M, Mantica, P, Mantsinen, M, Maraschek, M, Marchetto, C, Marchitti, M, Mardenfeld, M, Marechal, J, Marinelli, M, Marinoni, A, Marinucci, M, Maerki, J, Marocco, D, Marren, C, Martin, D, Martin, G, Martin, Y, Martin Solis, J, Masaki, K, Masiello, A, Maslov, M, Maszl, C, Matilal, A, Mattei, M, Matthews, G, Maviglia, F, May, C, Mayer, M, Mayoral, M, Mazon, D, Mazzotta, C, Mazzucato, E, Mccarthy, P, Mcclements, K, Mccormick, K, Mccullen, P, Mccune, D, Mcdonald, D, Mcgregor, R, Mckivitt, J, Meakins, A, Medina, F, Meigs, A, Menard, M, Meneses, L, Menmuir, S, Merrigan, I, Mertens, P, Messiaen, A, Meyer, H, Miano, G, Miele, M, Migliucci, P, Miller, A, Mills, S, Milnes, J, Min Kim, K, Mindham, T, Mirizzi, F, Mirones, E, Mironov, M, Mitteau, R, Mlynar, J, Mollard, P, Monakhov, I, Monier Garbet, P, Mooney, R, Moradi, S, Moreau, D, Moreau, P, Moreira, L, Morgan, A, Morgan, P, Morlock, C, Moro, A, Morris, A, Mort, G, Mrozek, C, Mueck, A, Mueller, H, Murakami, M, Murari, A, Mustata, I, Nabais, F, Nardon, E, Nash, G, Naulin, V, Nave, M, Nazikian, R, Nedzelski, I, Negus, C, Neilson, J, Neto, A, Neu, R, Neubauer, O, Newbert, G, Newman, M, Nicholls, K, Nicolai, A, Nicolas, L, Nieckchen, P, Nielsen, P, Nielsen, A, Nielsen, S, Nielson, G, Nieto, J, Nightingale, M, Noble, C, Nocente, M, Nora, M, Nordman, H, Norman, M, Noterdaeme, J, Nowak, S, Nunes, I, Ognissanto, F, O'Gorman, T, Olariu, S, Oleynikov, A, O'Mullane, M, Ongena, J, Orsitto, F, Oswuigwe, O, Ottaviani, M, Oyama, N, Pacella, D, Paget, K, Palazzo, S, Pamela, J, Pamela, S, Panek, R, Pangione, L, Panin, A, Panis, T, Pankin, A, Pantea, A, Parail, V, Parisot, T, Parkin, A, Parsloe, A, Parsons, B, Pasqualotto, R, Pastor, P, Paterson, R, Paul, M, Peach, D, Pearce, R, Pearson, B, Pearson, I, Pedrick, L, Pedrosa, M, Pegourie, B, Pereira, R, Perelli Cippo, E, Pereverzev, G, Perevezentsev, A, Perez von Thun, C, Pericoli Ridolfini, V, Perona, A, Perrot, Y, Peruzzo, S, Peschanyy, S, Petravich, G, Petrizzi, L, Petrov, V, Petrzilka, V, Philipps, V, Piazza, G, Piccolo, F, Pietropaolo, A, Pillon, M, Pinches, S, Pinna, T, Pintsuk, G, Piovesan, P, Pironti, A, Pisano, F, Pitts, R, Plaum, B, Plyusnin, V, Polasik, M, Poli, F, Pomaro, N, Pompilian, O, Poncet, L, Pool, P, Popovichev, S, Porcelli, F, Porfiri, M, Portafaix, C, Pospieszczyk, A, Possnert, G, Prestopino, G, Prior, P, Prokopowicz, R, Proverbio, L, Pugno, R, Puiatti, M, Purahoo, K, Pustovitov, V, Puetterich, T, Puettmann Kneupner, D, Quercia, A, Rachlew, E, Rademaker, R, Rafiq, T, Rainford, M, Ramogida, G, Rantamaeki, K, Rapp, J, Rasmussen, J, Ratta, G, Ravera, G, Reich, M, Reichle, R, Reiser, D, Reiss, R, Reiter, D, Rendell, D, Reux, C, Rewoldt, G, Ribeiro, T, Riccardo, V, Richards, D, Rigollet, F, Rimini, F, Rios, L, Riva, M, Roberts, J, Robins, R, Robinson, D, Robinson, S, Robson, D, Roche, H, Roedig, M, Rodionov, N, Rohde, V, Rolfe, A, Romanelli, M, Romano, A, Romero, J, Ronchi, E, Rosanvallon, S, Roux, C, Rowe, S, Rubel, M, Rubinacci, G, Ruchko, L, Ruiz, M, Ruset, C, Russell, M, Ruth, A, Ryc, L, Rydzy, A, Ryter, F, Rzadkiewicz, J, Saarelma, S, Sabathier, F, Sabot, R, Sadakov, S, Sagar, P, Saibene, G, Saille, A, Saint Laurent, F, Salmi, A, Salomaa, R, Salzedas, F, Samm, U, Sanchez, P, Sanders, S, Sandford, G, Sandland, K, Sandquist, P, Sands, D, Santala, M, Sartori, F, Sartori, R, Sauter, O, Savelyev, A, Savtchkov, A, Scales, S, Scarabosio, A, Schaefer, N, Schlatter, C, Schmidt, V, Schmidt, A, Schmitz, O, Schmuck, S, Schneider, M, Scholz, M, Schoepf, K, Schweer, B, Schweinzer, J, Scott, B, Seki, M, Semeraro, L, Semerok, A, Sergienko, G, Serra, F, Sertoli, M, Shannon, M, Sharapov, S, Shaw, S, Shevelev, A, Sievering, R, Silva, C, Simmons, P, Simonetto, A, Simpson, D, Sipila, S, Sips, A, Sirinelli, A, Sjoestrand, H, Skopintsev, D, Slabkowska, K, Smith, P, Snipes, J, Snoj, L, Snyder, S, Soare, S, Solano, E, Soldatov, S, Soleto, A, Solomon, W, Soltane, C, Sonato, P, Sopplesa, A, Sorrentino, A, Sousa, J, Sowden, C, Sozzi, C, Spaeh, P, Spelzini, T, Spence, J, Spineanu, F, Spuig, P, Staebler, A, Stagg, R, Stamp, M, Stancalie, V, Stangeby, P, Stan Sion, C, Starkey, D, Stead, M, Stephen, A, Stevens, A, Stober, J, Stokes, R, Stork, D, Stoyanov, D, Strachan, J, Strand, P, Stransky, M, Strauss, D, Strintzi, D, Studholme, W, Su Na, Y, Subba, F, Summers, H, Sun, Y, Surdu Bob, C, Surrey, E, Sutton, D, Svensson, J, Swain, D, Syme, B, Symonds, I, Szepesi, T, Szydlowski, A, Tabares, F, Takalo, V, Takenaga, H, Tala, T, Talbot, A, Taliercio, C, Tame, C, Tardini, G, Tardocchi, M, Taroni, L, Telesca, G, Terra, A, Terrington, A, Testa, D, Theis, J, Thomas, J, Thomas, P, Thompson, V, Thomsen, H, Thomser, C, Thyagaraja, A, Tigwell, P, Tiseanu, I, Tivey, R, Todd, J, Todd, T, Tokar, M, Tosti, S, Trabuc, P, Travere, J, Treutterer, W, Trimble, P, Trkov, A, Trukhina, E, Tsalas, M, Tsige Tamirat, H, Tsitrone, E, Tskhakaya, D, Tudisco, O, Tugarinov, S, Turner, M, Turri, G, Tyrrell, S, Umeda, N, Unterberg, B, Urano, H, Urquhart, A, Uytdenhouwen, I, Vaccaro, A, Vadgama, A, Vagliasindi, G, Valcarcel, D, Valisa, M, Vallory, J, Valovic, M, Van Eester, D, van Milligen, B, van Rooij, G, Varandas, C, Vartanian, S, Vdovin, V, Vega, J, Verdoolaege, G, Verger, J, Vermare, L, Verona, C, Versloot, T, Vervier, M, Vicente, J, Villari, S, Villedieu, E, Villone, F, Vince, J, Vine, G, Viola, B, Vitale, E, Vitelli, R, Vlad, M, Voitsekhovitch, I, Vrancken, M, Vulliez, K, Waldon, C, Walker, M, Walsh, M, Waterhouse, J, Watkins, M, Watson, M, Wauters, T, Way, M, Webb, C, Weiland, J, Weisen, H, Weiszflog, M, Wenninger, R, West, A, Weulersse, J, Weyssow, B, Wheatley, M, Whiteford, A, Whitehead, A, Whitehurst, A, Widdowson, A, Wieggers, R, Wiegmann, C, Wiesen, S, Wilson, A, Wilson, D, Wilson, H, Wischmeier, M, Witts, D, Wolf, R, Wolowski, J, Woscov, P, Wright, G, Wright, J, Xu, G, Yavorskij, V, Yerashok, V, Yorkshades, J, Young, C, Young, D, Young, I, Yuhong, X, Zabeo, L, Zabolotsky, A, Zaccarian, L, Zagorski, R, Zaitsev, F, Zajac, S, Zakharov, L, Zanino, R, Zaroschi, V, Zastrow, K, Zatz, I, Zefran, B, Zeidner, W, Zerbini, M, Zhang, T, Zhu, Y, Zilli, E, Zimmermann, O, Zoita, V, Zoletnik, S, Zwingman, W, Correction Romanelli, F, Albanese, R., Ambrosino, G., Andersson Sundén, E., Bécoulet, M., Bellizio, T., Belonohy, É., Bovert, K. V., Cação, R., Calabró, G., Carannante, G., Coccorese, V., De Arcas, G., De Baar, M. R., De La Cal, E., De La Luna, E., De Pablos, J. L., De Tommasi, G., De Vries, P. C., Del Castillo Negrete, D., Di Pace, L., Durodié, F., Formisano, Alessandro, Gál, K., Galvão, R., Garcia Munoz, M., Goloborod'Ko, V., Gonçalves, B., González De Vicente, S. M., Grünhagen, S., Hallworth Cook, S. P., Hühnerbein, M., Hynönen, V., Jupén, C., Källne, J., Kálvin, S., Köchl, F., Kühnlein, W., Le Guern, F., Lönnroth, J., Märki, J., Martín Solís, J. R., Mattei, Massimiliano, Miano, G., Müller, H. W., O'Gorman, T., O'Mullane, M., Perez Von Thun, C. h., Pironti, A., Pütterich, T. h., Püttmann Kneupner, D., Quercia, A., Rantamäki, K., Rattá, G., Rödig, M., Rubinacci, G., Schöpf, K., Sjöstrand, H., Slabkowska, K., Späh, P., Stäbler, A., Su Na, Y., Tskhakaya Jun, D., Van Milligen, B., Van Rooij, G. J., Xu, G. S., Faculdade de Engenharia, Kamendjea, R., Alarcon, Th., Andersson-Sundén, E., Andrew, P. L., Argouach, A., Balbao, I., Berger-By, G., Bergkvist, T., Coutois, X., David, E., De-Angelis, R., Del-Castillo-Negrete, D., De-Tommasi, G., Deveaux, S., Eich, Th., Erents, S. K., Gatu-Johnson, M., Holmström, K., Kurki-Suonio, T., Lauro Taroni, L., Laxaback, M., Liu, Y. Q., Llewellyn Smith, C., Maviglia, A., Mertens, Ph., Monier-Garbet, P., Moreau, Ph., Norris, C., Noterdaeme, J. -M., Paméla, J., Panis, Th., Parisot, Th., Perez Von Thun, C., Perez Von Thun, Ch., Pericoli-Ridolfini, V., Phillips, V., Pütterich, Th., Püttmann-Kneupner, D., Roux, Ch., Saint-Laurent, F., Schlatter, Ch., Sundelin, P., Surdu-Bob, C., Hompson, V. K., Tsige-Tamirat, H., Tskhakaya, D., Uytdenhoven, I., Versloot, Th., Villedieux, E., Walden, A. D., Paméla, J, and Jet, C

Subjects
Nuclear and High Energy Physics, 52.55.Fa Tokamaks, spherical tokamak, Materials science, Tokamak, Physics and Astronomy (all), Condensed Matter Physics, Física [Ciências exactas e naturais], Cyclotron, law.invention, Bootstrap current, Physical sciences [Natural sciences], law, Physics::Plasma Physics, ITER, divertor, FIS/03 - FISICA DELLA MATERIA, Nuclear and High Energy Physic, Jet (fluid), Safety factor, Divertor, 52.50.Qt Plasma heating by radio-frequency field, Settore FIS/01 - Fisica Sperimentale, magnetic confinement, Magnetic confinement fusion, Física, 52.55.Rk Power exhaust, JET, overview, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Computational physics, Physical sciences, ICR, ICP, helicons, ___, JET, Beta (plasma physics), Atomic physics, tokamaks
Abstract

Since the last IAEA conference, the scientific programme of JET has focused on the qualification of the integrated operating scenarios for ITER and on physics issues essential for the consolidation of design choices and the efficient exploitation of ITER. Particular attention has been given to the characterization of the edge plasma, pedestal energy and edge localized modes (ELMs), and their impact on plasma facing components (PFCs). Various ELM mitigation techniques have been assessed for all ITER operating scenarios using active methods such as resonant magnetic field perturbation, rapid variation of the radial field and pellet pacing. In particular, the amplitude and frequency of type I ELMs have been actively controlled over a wide parameter range (q(95) = 3-4.8, beta(N)

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114. Structural Positive Electrodes Engineered for Multifunctionality

Author

Richa Chaudhary, Amit Chetry, Johanna Xu, Zhenyuan Xia, and Leif E. Asp

Subjects
carbon fibre, electrophoretic deposition, lithium‐ion batteries, lithium‐iron phosphate, reduced graphene oxide, structural batteries, Science
Abstract

Abstract Multifunctional structural batteries are of high and emerging interest in a wide variety of high‐strength and lightweight applications. Structural batteries typically use pristine carbon fiber as the negative electrode, functionalized carbon fiber as the positive electrode, and a mechanically robust lithium‐ion transporting electrolyte. However, electrochemical cycling of carbon fibre‐based positive electrodes is still limited to tests in liquid electrolytes, which does not allow for to introduction of multifunctionality in real terms. To overcome these limitations, structural batteries with a structural battery electrolyte (SBE) are developed. This approach offers massless energy storage. The electrodes are manufactured using economically friendly, abundant, cheap, and non‐toxic iron‐based materials like olivine LiFePO4. Reduced graphene oxide, renowned for its high surface area and electrical conductivity, is incorporated to enhance the ion transport mechanism. Furthermore, a vacuum‐infused solid‐liquid electrolyte is cured to bolster the mechanical strength of the carbon fibers and provide a medium for lithium‐ion migration. Electrophoretic deposition is selected as a green process to manufacture the structural positive electrodes with homogeneous mass loading. A specific capacity of 112 mAh g−1 can be reached at C/20, allowing the smooth transport of Li‐ion in the presence of SBE. The modulus of positive electrodes exceeded 80 GPa. Structural battery‐positive half‐cells are demonstrated across various mass‐loadings, enabling them to be tailored for a diverse array of applications in consumer technology, electric vehicles, and aerospace sectors.

Published
2024
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115. Robust numerical analysis of fibrous composites from X-ray computed tomography image data enabling low resolutions

Author

Robert M. Auenhammer, Niels Jeppesen, Lars P. Mikkelsen, Vedrana A. Dahl, Brina J. Blinzler, and Leif E. Asp

Subjects
X-ray computed tomography, Computational mechanics, Computer Science, General Engineering, Ceramics and Composites, Composite materials, Structure tensor, Composite Science and Engineering, Finite element modelling
Abstract

X-ray computed tomography scans can provide detailed information about the state of the material after manufacture and in service. X-ray computed tomography aided engineering (XAE) was recently introduced as an automated process to transfer 3D image data to finite element models. The implementation of a structure tensor code for material orientation analysis in combination with a newly developed integration pointwise fibre orientation mapping allows an easy applicable, computationally cheap, fast, and accurate model set-up. The robustness of the proposed approach is demonstrated on a non-crimp fabric glass fibre reinforced composite for a low resolution case with a voxel size of 64 µm corresponding to more than three times the fibre diameter. Even though 99.8 % of the original image data is removed, the simulated elastic modulus of the considered non-crimp fabric composite is only underestimated by 4.7 % compared to the simulation result based on the original high resolution scan.

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116. X-ray scattering tensor tomography based finite element modelling of heterogeneous materials

Author

Robert M. Auenhammer, Jisoo Kim, Carolyn Oddy, Lars P. Mikkelsen, Federica Marone, Marco Stampanoni, and Leif E. Asp

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492, Computer software, QA76.75-76.765
Abstract

Abstract Among micro-scale imaging technologies of materials, X-ray micro-computed tomography has evolved as most popular choice, even though it is restricted to limited field-of-views and long acquisition times. With recent progress in small-angle X-ray scattering these downsides of conventional absorption-based computed tomography have been overcome, allowing complete analysis of the micro-architecture for samples in the dimension of centimetres in a matter of minutes. These advances have been triggered through improved X-ray optical elements and acquisition methods. However, it has not yet been shown how to effectively transfer this small-angle X-ray scattering data into a numerical model capable of accurately predicting the actual material properties. Here, a method is presented to numerically predict mechanical properties of a carbon fibre-reinforced polymer based on imaging data with a voxel-size of 100 μm corresponding to approximately fifteen times the fibre diameter. This extremely low resolution requires a completely new way of constructing the material’s constitutive law based on the fibre orientation, the X-ray scattering anisotropy, and the X-ray scattering intensity. The proposed method combining the advances in X-ray imaging and the presented material model opens for an accurate tensile modulus prediction for volumes of interest between three to six orders of magnitude larger than those conventional carbon fibre orientation image-based models can cover.

Published
2024
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119. Advancing Structural Battery Composites: Robust Manufacturing for Enhanced and Consistent Multifunctional Performance

Author

Mohammad Siam Siraj, Samia Tasneem, David Carlstedt, Shanghong Duan, Marcus Johansen, Carl Larsson, Johanna Xu, Fang Liu, Fredrik Edgren, and Leif E. Asp

Subjects
biomimetics, carbon fiber composites, lithium-ion batteries, multifunctional materials, resin-infusion, self-sustaining materials, Environmental technology. Sanitary engineering, TD1-1066, Renewable energy sources, TJ807-830
Abstract

Multifunctional materials offer a possibility to create lighter and more resource‐efficient products and thereby improve energy efficiency. Structural battery composites are one type of such a multifunctional material with potential to offer massless energy storage for electric vehicles and aircraft. Although such materials have been demonstrated, their performance level and consistency must be improved. Also, the cell dimensions need to be increased. Herein, a robust manufacturing procedure is developed and structural battery composite cells are repeatedly manufactured with double the multifunctional performance and size compared to state‐of‐the‐art structural battery cells. Furthermore, six structural battery cells are selected and laminated into a structural battery composite multicell demonstrator to showcase the technology. The multicell demonstrator performance is characterized for two different electrical configurations. The low variability in the multifunctional properties of the cells verifies the potential for upscaling offered by the proposed manufacture technique.

Published
2023
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120. Dataset of non-crimp fabric reinforced composites for an X-ray computer tomography aided engineering process

Author

Robert M. Auenhammer, Lars P. Mikkelsen, Leif E. Asp, and Brina J. Blinzler

Subjects
Composites, X-ray computer tomography, Segmentation, Finite element modelling, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract

This data in brief article describes a dataset used for an X-ray computer tomography aided engineering process consisting of X-ray computer tomography data and finite element models of non-crimp fabric glass fibre reinforced composites. Additional scanning electron microscope images are provided for the validation of the fibre volume fraction. The specimens consist of 4 layers of unidirectional bundles each supported by off-axis backing bundles with an average orientation on ±80° The finite element models, which were created solely on the image data, simulate the tensile stiffness of the samples. The data can be used as a benchmark dataset to apply different segmentation algorithms on the X-ray computer tomography data. It can be further used to run the models using different finite element solvers.

Published
2020
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121. Composite Design for a Foiling Optimist Dinghy

Author

Carolyn Oddy, Elias Blomstrand, Daniel Johansson, Niklas Karlsson, Niklas Olofsson, Petra Steen, Martin Fagerström, Leif E. Asp, John McVeagh, Matz Brown, and Christian Finnsgård

Subjects
carbon fibre reinforced polymer design, Optimist dinghy, foiling, General Works
Abstract

In April 2017, a foiling Optimist dingy designed entirely by students, was successfully tested under standard sailing conditions in the waters outside Gothenburg. In order to achieve take of wind speeds as low as 6 m/s, a stiff and lightweight design of the dinghy and its foiling components was necessary. There have been few successful attempts to make an Optimist foil in a stable manner, as such there were no standards or recommendations available for the design. Therefore, a simulation driven structural design methodology for hydrofoils, centreboards, centreboard-to-hull connections, and necessary hull reinforcements using sandwich structures was adopted. The proposed design was then manufactured, allowing for a significantly stiffer hull and a 20% decrease in weight over a conventional Optimist. Excluding the rig and sail, the final weight came to 27 kg.

Published
2018
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122. Monensin induces secretory granule-mediated cell death in eosinophils.

Author

Vraila M, Asp E, Melo FR, Grujic M, Rollman O, Pejler G, and Lampinen M

Subjects
Humans, Granzymes metabolism, Granzymes pharmacology, Secretory Vesicles metabolism, Cytoplasmic Granules, Eosinophils, Monensin pharmacology, Monensin metabolism
Abstract

Background: Eosinophils contribute to the pathology of several types of disorders, in particular of allergic nature, and strategies to limit their actions are therefore warranted., Objective: We sought to evaluate the possibility of targeting the acidic, lysosome-like eosinophil granules as a potential means of inducing eosinophil cell death., Methods: To this end, we used monensin, an ionophoric drug that has previously been shown to permeabilize the secretory granules of mast cells, thereby inducing cell death., Results: Our findings reveal that monensin induces cell death in human eosinophils, whereas neutrophils were less affected. Blockade of granule acidification reduced the effect of monensin on the eosinophils, demonstrating that granule acidity is an important factor in the mechanism of cell death. Furthermore, monensin caused an elevation of the granule pH, which was accompanied by a decrease of the cytosolic pH, hence indicating that monensin caused leakage of acidic contents from the granules into the cytosol. In agreement with a granule-targeting mechanism, transmission electron microscopy analysis revealed that monensin caused extensive morphological alterations of the eosinophil granules, as manifested by a marked loss of electron density. Eosinophil cell death in response to monensin was caspase-independent, but dependent on granzyme B, a pro-apoptotic serine protease known to be expressed by eosinophils., Conclusions: We conclude that monensin causes cell death of human eosinophils through a granule-mediated mechanism dependent on granzyme B., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2023
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123. Fetal alcohol spectrum disorder and confabulation in psycholegal settings: A beginner's guide for criminal justice, forensic mental health, and legal interviewers.

Author

Brown J, Jonason A, Asp E, McGinn V, Carter MN, Spiller V, and Jozan A

Subjects
Adult, Crime, Criminal Law, Female, Humans, Mental Health, Pregnancy, Fetal Alcohol Spectrum Disorders, Prenatal Exposure Delayed Effects
Abstract

Fetal alcohol spectrum disorders (FASD) are neurodevelopmental/neurobehavioral conditions caused by prenatal alcohol exposure (PAE). Impairments caused by PAE contribute to the over-representation of individuals with FASD in the United States juvenile and adult criminal justice systems. These same impairments can equally impact on individuals with FASD who are witnesses to or victims of crime who also have to navigate the complexities of the criminal justice system. Difficulties include increased susceptibility to confabulation throughout the legal process that, in turn, can contribute to increased rates of poor outcomes including false confessions and wrongful convictions. Individuals with FASD are particularity at risk of confabulation when they are subjected to tactics, such as stressful and anxiety-provoking situations, threats, and leading, suggestive, or coercive questioning. Many professionals in the forensic context are unfamiliar with FASD or related confabulation risk and may unintentionally utilize tactics that intensify impacts of pre-existing impairment. This article serves as a beginner's guide for professionals working in criminal justice settings by (a) providing research-based overviews of FASD and confabulation, (b) describing how FASD may lead to confabulation, and (c) suggesting ways that professionals can modify protocols when interacting with individuals with FASD. Suggestions in this article hold the potential to decrease the risk of confabulation in the criminal justice system and decrease problematic outcomes, such as false confessions and wrongful convictions among individuals with FASD., (© 2021 John Wiley & Sons Ltd.)

Published
2022
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124. Suggestibility and confabulation among individuals with Fetal Alcohol Spectrum Disorder: A review for criminal justice, forensic mental health, and legal interviewers.

Author

Brown J, Asp E, Carter MN, Spiller V, and Bishop-Deaton D

Subjects
Comorbidity, Humans, Fetal Alcohol Spectrum Disorders diagnosis, Fetal Alcohol Spectrum Disorders epidemiology, Fetal Alcohol Spectrum Disorders psychology, Interviews as Topic methods, Law Enforcement methods, Neurodevelopmental Disorders epidemiology, Suggestion
Abstract

Fetal Alcohol Spectrum Disorders (FASD) are conditions arising from prenatal alcohol exposure which results in a range of neurodevelopmental deficits in areas including cognition, memory, language, executive functioning, emotional regulation, and adaptive functioning. Deficits in various neurodevelopmental areas can range from mild to severe, depending on many factors including the quantity and timing of alcohol exposure during the prenatal development period. During interviews in criminal justice, forensic mental health, and legal contexts (e.g., criminal investigations, cross examination, victim interviews, interviews for lawsuits, forensic evaluations, pre-sentence investigations), deficits associated with FASD may elevate the risk of suggestibility and confabulation. These issues can result in negative jurisprudence-related outcomes, including impulsive Miranda rights waivers, incorrect assumptions of competency, inaccurate or incomplete information gathering, misinterpretation of intent, witness reliability issues, court ordered treatment completion problems, probation and parole violations, false confessions, and false accusations. The aim of the present article is to explain the context in which these issues can arise and provide criminal justice, forensic mental health, and legal professionals with key guidelines that can assist in minimizing suggestibility and confabulation when interviewing persons with FASD. We hope that the suggestions and strategies presented in this article will reduce potential obstructions of justice and enhance the quality of information obtained from individuals impacted by FASD. A brief discussion is also provided to identify additional research and training opportunities needed to clarify "best practices" for professionals tasked with evaluating the challenges facing this unique population., (Copyright © 2020. Published by Elsevier Ltd.)

Published
2020
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125. Measuring the complex syntax of school-aged children in language sample analysis: A known-groups validation study.

Author

Cahill P, Cleave P, Asp E, Squires B, and Kay-Raining Bird E

Subjects
Child, Cross-Sectional Studies, Female, Humans, Male, Multilingualism, Nova Scotia, Reproducibility of Results, Students psychology, Child Language, Language Development Disorders diagnosis, Language Tests standards, Linguistics
Abstract

Background: Complex syntax is affected by developmental language disorder (DLD) during the school years. Targeting areas of syntactic difficulty for children with DLD may yield useful assessment techniques., Aims: To determine whether wh-movement can be measured in language samples from typically developing mono- and bilingual school-aged children, and, if so, to provide preliminary evidence of validity by comparison with traditional measures of syntax in a cross-sectional, known-groups design., Methods & Procedures: Participants were 48 typically developing children recruited from the Canadian province of Nova Scotia in four groups: monolingual English and bilingual French-English children in early (7-8 years of age) and late (11-12 years of age) elementary school. Language samples were collected and analysed with mean use of wh-movement, mean length of utterance and clausal density. These measures were compared for effects of age, bilingual development and elicitation task., Outcomes & Results: The results from all measures closely paralleled each other, providing preliminary evidence of validity. Wh-movement-based and traditional measures demonstrated similar age-related and discourse genre effects. Neither demonstrated an effect of mono- versus bilingual development., Conclusions & Implications: The results confirm research interest in syntactic movement as an area of language assessment. Further research is required to understand its application to clinical populations. What this paper adds What is already known on the subject Complex syntax is known to be an area of difficulty for children with DLD. Certain syntactic constructions appear to be particularly difficult for these children. Assessments targeting these areas of difficulty are emerging. What this paper adds to existing knowledge The paper compares traditional measures of syntax with measures based on wh-movement. It shows similar results for both types of measures, suggesting construct and convergent validity. Results suggest that syntactic movement is an age-appropriate area of assessment for elementary school-aged children's language. What are the potential or actual clinical implications of this work? Language sample assessment measures based on wh-movement appear promising. The impact of task effects of the discourse genre on assessing syntax must be carefully considered in research and clinical practice., (© 2020 Royal College of Speech and Language Therapists.)

Published
2020
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126. Stability and Inter-domain Interactions Modulate Amyloid Binding Activity of a General Amyloid Interaction Motif.

Author

Asp E, Proschitsky M, Lulu M, Rockwell-Postel C, Tsubery H, and Krishnan R

Subjects
Amyloidogenic Proteins chemistry, Animals, Escherichia coli chemistry, Escherichia coli Proteins chemistry, Humans, Models, Molecular, Protein Binding, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Unfolding, Recombinant Fusion Proteins chemistry, Recombinant Fusion Proteins metabolism, Amyloidogenic Proteins metabolism, Escherichia coli metabolism, Escherichia coli Proteins metabolism
Abstract

The M13 tip protein, g3p, binds the C-terminal domain of the bacterial membrane protein TolA via β-sheet augmentation, facilitating viral entry into Escherichia coli. G3p binding leads to rearrangement of the β strands and partial unfolding of TolA. G3p also binds multiple amyloid assemblies with high affinity, and it can remodel them into amorphous aggregates. We previously showed that amyloid binding activity is defined by the two g3p N-terminal domains, which we call the general amyloid interaction motif (GAIM). GAIM-hIgG1Fc fusions, which add immune effector function to amyloid targeting of GAIM, mediate reduction of two CNS amyloid deposits, Aβ plaques and tau tangles, in transgenic animal models of neurodegenerative disease. We carried out site-directed mutagenesis of GAIM to identify variants with altered amyloid binding and remodeling activity. A small set of residues along the inner strands of the two domains regulates both activities. The specificity of amyloid binding is governed by individual domain stability and inter-domain interactions. Our studies reveal several lines of similarity between GAIM binding to amyloids and g3p binding to its E. coli membrane target, TolA. Based on these studies, we designed new GAIM fusions that show enhanced binding potency towards multiple amyloid aggregates., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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127. NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.

Author

Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH, Gilead S, Nadeem M, Dodiya HB, Shoaga S, Mufson EJ, Tsubery H, Krishnan R, Wright J, Solomon B, Fisher R, and Gannon KS

Abstract

Introduction: Alzheimer's disease (AD) is characterized by appearance of both extracellular senile plaques and intracellular neurofibrillary tangles, comprised of aggregates of misfolded amyloid-β (Aβ) and hyper-phosphorylated tau, respectively. In a previous study, we demonstrated that g3p, a capsid protein from bacteriophage M13, binds to and remodels misfolded aggregates of proteins that assume an amyloid conformation. We engineered a fusion protein ("NPT088") consisting of the active fragment of g3p and human-IgG 1 -Fc., Methods: Aged Tg2576 mice or rTg4510 mice received NPT088 weekly via IP injection. Cognitive and/or functional motor endpoints were monitored during dosing. Pathology was quantified biochemically and immunohistochemically., Results: NPT088-lowered Aβ plaque and improved cognitive performance of aged Tg2576 mice. Moreover, NPT088 reduced phospho-tau pathology, reduced brain atrophy, and improved cognition in rTg4510 mice., Discussion: These observations establish NPT088 as a novel therapeutic approach and potential drug class that targets both Aβ and tau, the hallmark pathologies of AD.

Published
2016
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128. Mediterranean Way of Drinking and Longevity.

Author

Giacosa A, Barale R, Bavaresco L, Faliva MA, Gerbi V, La Vecchia C, Negri E, Opizzi A, Perna S, Pezzotti M, and Rondanelli M

Subjects
Cardiovascular Diseases prevention & control, Female, Flavonols chemistry, Humans, Liver Cirrhosis epidemiology, Liver Cirrhosis etiology, Male, Mediterranean Region, Neoplasms epidemiology, Neoplasms etiology, Phenols chemistry, Resveratrol, Risk Factors, Sex Factors, Sirtuins drug effects, Sirtuins metabolism, Stilbenes administration & dosage, Alcohol Drinking adverse effects, Alcohol Drinking mortality, Diet, Mediterranean, Longevity, Wine analysis
Abstract

The relation between alcohol consumption and mortality is a J-shaped curve in most of the many studies published on this topic. The Copenhagen Prospective Population Studies demonstrated in the year 2000 that wine intake may have a beneficial effect on all cause mortality that is additive to that of alcohol. Wine contains various poliphenolic substances which may be beneficial for health and in particular flavonols (such as myricetin and quercetin), catechin and epicatechin, proanthocyanidins, anthocyanins, various phenolic acids and the stilbene resveratrol. In particular, resveratrol seems to play a positive effect on longevity because it increases the expression level of Sirt1, besides its antioxidant, anti-inflammatory and anticarcinogenic properties. Moderate wine drinking is part of the Mediterranean diet, together with abundant and variable plant foods, high consumption of cereals, olive oil as the main (added) fat and a low intake of (red) meat. This healthy diet pattern involves a "Mediterranean way of drinking," that is a regular, moderate wine consumption mainly with food (up to two glasses a day for men and one glass for women). Moderate wine drinking increases longevity, reduces the risk of cardiovascular diseases and does not appreciably influence the overall risk of cancer.

Published
2016
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129. Remodeling Amyloid Fibers: Baker's Yeast Shows Us the Way.

Author

Asp E, Proschitsky M, and Krishnan R

Subjects
Humans, Male, Amyloid antagonists & inhibitors, Anti-HIV Agents chemistry, Anti-HIV Agents pharmacology, HIV Infections drug therapy, HIV-1, Heat-Shock Proteins chemistry, Heat-Shock Proteins pharmacology, Peptide Fragments chemistry, Peptide Fragments pharmacology, Saccharomyces cerevisiae Proteins chemistry, Saccharomyces cerevisiae Proteins pharmacology
Abstract

Proteopathies are a large and diverse group of human diseases that are caused by protein misfolding. Well-known examples of proteopathies are Alzheimer's and Parkinson's disease, which are both linked to amyloid fibril formation. In this issue of Chemistry & Biology, Castellano et al. (2015) describe the way to harness the power of a protein from baker's yeast, Hsp104, to disaggregate the fibrils., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Published
2015
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130. A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

Author

Krishnan R, Tsubery H, Proschitsky MY, Asp E, Lulu M, Gilead S, Gartner M, Waltho JP, Davis PJ, Hounslow AM, Kirschner DA, Inouye H, Myszka DG, Wright J, Solomon B, and Fisher RA

Subjects
Bacterial Outer Membrane Proteins chemistry, Bacterial Outer Membrane Proteins metabolism, Bacteriophage M13 genetics, Capsid Proteins genetics, Escherichia coli Proteins chemistry, Escherichia coli Proteins metabolism, Humans, Kinetics, Membrane Transport Proteins chemistry, Membrane Transport Proteins metabolism, Models, Molecular, Neurodegenerative Diseases etiology, Neurodegenerative Diseases metabolism, Protein Binding, Protein Conformation, Protein Folding, Protein Interaction Domains and Motifs, Protein Multimerization, Recombinant Fusion Proteins chemistry, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins metabolism, alpha-Synuclein chemistry, alpha-Synuclein metabolism, tau Proteins chemistry, tau Proteins metabolism, Amyloid beta-Peptides chemistry, Amyloid beta-Peptides metabolism, Bacteriophage M13 metabolism, Capsid Proteins chemistry, Capsid Proteins metabolism
Abstract

Misfolded protein aggregates, characterized by a canonical amyloid fold, play a central role in the pathobiology of neurodegenerative diseases. Agents that bind and sequester neurotoxic intermediates of amyloid assembly, inhibit the assembly or promote the destabilization of such protein aggregates are in clinical testing. Here, we show that the gene 3 protein (g3p) of filamentous bacteriophage mediates potent generic binding to the amyloid fold. We have characterized the amyloid binding and conformational remodeling activities using an array of techniques, including X-ray fiber diffraction and NMR. The mechanism for g3p binding with amyloid appears to reflect its physiological role during infection of Escherichia coli, which is dependent on temperature-sensitive interdomain unfolding and cis-trans prolyl isomerization of g3p. In addition, a natural receptor for g3p, TolA-C, competitively interferes with Aβ binding to g3p. NMR studies show that g3p binding to Aβ fibers is predominantly through middle and C-terminal residues of the Aβ subunit, indicating β strand-g3p interactions. A recombinant bivalent g3p molecule, an immunoglobulin Fc (Ig) fusion of the two N-terminal g3p domains, (1) potently binds Aβ fibers (fAβ) (KD=9.4nM); (2); blocks fAβ assembly (IC50~50nM) and (3) dissociates fAβ (EC50=40-100nM). The binding of g3p to misfolded protein assemblies is generic, and amyloid-targeted activities can be demonstrated using other misfolded protein systems. Taken together, our studies show that g3p(N1N2) acts as a general amyloid interaction motif., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Published
2014
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131. A new role for Hedgehogs in juxtacrine signaling.

Author

Pettigrew CA, Asp E, and Emerson CP Jr

Subjects
Animals, Carcinogenesis genetics, Female, Hedgehog Proteins genetics, Humans, Male, Paracrine Communication, Pregnancy, Prostatic Neoplasms genetics, Prostatic Neoplasms pathology, Protein Processing, Post-Translational, Signal Transduction genetics, Cell Differentiation genetics, Hedgehog Proteins metabolism
Abstract

The Hedgehog pathway plays important roles in embryonic development, adult stem cell maintenance and tumorigenesis. In mammals these effects are mediated by Sonic, Desert and Indian Hedgehog (Shh, Dhh and Ihh). Shh undergoes autocatalytic cleavage and dual lipidation prior to secretion and forming a response gradient. Post-translational processing and secretion of Dhh and Ihh ligands has not previously been investigated. This study reports on the synthesis, processing, secretion and signaling activities of SHH, IHH and DHH preproteins expressed in cultured cells, providing unexpected evidence that DHH does not undergo substantial autoprocessing or secretion, and does not function in paracrine signaling. Rather, DHH functions as a juxtacrine signaling ligand to activate a cell contact-mediated HH signaling response, consistent with its localised signaling in vivo. Further, the LnCAP prostate cancer cell, when induced to express endogenous DHH and SHH, is active only in juxtacrine signaling. Domain swap studies reveal that the C-terminal domain of HH regulates its processing and secretion. These findings establish a new regulatory role for HHs in cell-mediated juxtacrine signaling in development and cancer., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)

Published
2014
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132. Benefit of the doubt: a new view of the role of the prefrontal cortex in executive functioning and decision making.

Author

Asp E, Manzel K, Koestner B, Denburg NL, and Tranel D

Abstract

The False Tagging Theory (FTT) is a neuroanatomical model of belief and doubt processes that proposes a single, unique function for the prefrontal cortex. Here, we review evidence pertaining to the FTT, the implications of the FTT regarding fractionation of the prefrontal cortex, and the potential benefits of the FTT for new neuroanatomical conceptualizations of executive functions. The FTT provides a parsimonious account that may help overcome theoretical problems with prefrontal cortex mediated executive control such as the homunculus critique. Control in the FTT is examined via the "heuristics and biases" psychological framework for human judgment. The evidence indicates that prefrontal cortex mediated doubting is at the core of executive functioning and may explain some biases of intuitive judgments.

Published
2013
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133. A quantitative meta-analysis of functional imaging studies of social rejection.

Author

Cacioppo S, Frum C, Asp E, Weiss RM, Lewis JW, and Cacioppo JT

Subjects
Cerebral Cortex, Humans, Brain Mapping, Magnetic Resonance Imaging, Psychological Distance
Abstract

Early neuroimaging studies using Cyberball suggested that social rejection activated the pain matrix, as identified in studies of physical pain. However, these early studies were characterized by small sample sizes. Our statistical multi-level kernel density analysis (MKDA) of Cyberball neuroimaging studies with 244 participants fails to support the claim that social rejection operates on the same pain matrix as nociceptive stimuli, questioning whether social pain is more figurative or literal. We also performed an MKDA of the neuroimaging studies of reliving a romantic rejection to test whether the pain matrix was activated if the rejection were more meaningful. Results again failed to support the notion that rejection activates the neural matrix identified in studies of physical pain. Reliving an unwanted rejection by a romantic partner was significantly characterized by activation within and beyond the "Cyberball" brain network, suggesting that the neural correlates of social pain are more complex than previously thought.

Published
2013
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134. Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.

Author

Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, and Himmelfarb J

Subjects
Cell Culture Techniques, Cell Survival drug effects, Endothelial Cells cytology, Endothelial Cells drug effects, Epithelial Cells cytology, Epithelial Cells drug effects, Humans, Microfluidic Analytical Techniques instrumentation, Microfluidic Analytical Techniques methods, Pericytes cytology, Pericytes drug effects, Xenobiotics toxicity, Kidney Tubules cytology
Abstract

Kidney disease is a public health problem that affects more than 20 million people in the US adult population, yet little is understood about the impact of kidney disease on drug disposition. Consequently there is a critical need to be able to model the human kidney and other organ systems, to improve our understanding of drug efficacy, safety, and toxicity, especially during drug development. The kidneys in general, and the proximal tubule specifically, play a central role in the elimination of xenobiotics. With recent advances in molecular investigation, considerable information has been gathered regarding the substrate profiles of the individual transporters expressed in the proximal tubule. However, we have little knowledge of how these transporters coupled with intracellular enzymes and influenced by metabolic pathways form an efficient secretory and reabsorptive mechanism in the renal tubule. Proximal tubular secretion and reabsorption of xenobiotics is critically dependent on interactions with peritubular capillaries and the interstitium. We plan to robustly model the human kidney tubule interstitium, utilizing an ex vivo three-dimensional modular microphysiological system with human kidney-derived cells. The microphysiological system should accurately reflect human physiology, be usable to predict renal handling of xenobiotics, and should assess mechanisms of kidney injury, and the biological response to injury, from endogenous and exogenous intoxicants.

Published
2013
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135. A neuropsychological test of belief and doubt: damage to ventromedial prefrontal cortex increases credulity for misleading advertising.

Author

Asp E, Manzel K, Koestner B, Cole CA, Denburg NL, and Tranel D

Abstract

We have proposed the False Tagging Theory (FTT) as a neurobiological model of belief and doubt processes. The theory posits that the prefrontal cortex is critical for normative doubt toward properly comprehended ideas or cognitions. Such doubt is important for advantageous decisions, for example in the financial and consumer purchasing realms. Here, using a neuropsychological approach, we put the FTT to an empirical test, hypothesizing that focal damage to the ventromedial prefrontal cortex (vmPFC) would cause a "doubt deficit" that would result in higher credulity and purchase intention for consumer products featured in misleading advertisements. We presented 8 consumer ads to 18 patients with focal brain damage to the vmPFC, 21 patients with focal brain damage outside the prefrontal cortex, and 10 demographically similar healthy comparison participants. Patients with vmPFC damage were (1) more credulous to misleading ads; and (2) showed the highest intention to purchase the products in the misleading advertisements, relative to patients with brain damage outside the prefrontal cortex and healthy comparison participants. The pattern of findings was obtained even for ads in which the misleading bent was "corrected" by a disclaimer. The evidence is consistent with our proposal that damage to the vmPFC disrupts a "false tagging mechanism" which normally produces doubt and skepticism for cognitive representations. We suggest that the disruption increases credulity for misleading information, even when the misleading information is corrected for by a disclaimer. This mechanism could help explain poor financial decision-making when persons with ventromedial prefrontal dysfunction (e.g., caused by neurological injury or aging) are exposed to persuasive information.

Published
2012
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136. Authoritarianism, religious fundamentalism, and the human prefrontal cortex.

Author

Asp E, Ramchandran K, and Tranel D

Subjects
Adult, Aged, Brain Injuries etiology, Female, Humans, Male, Middle Aged, Multivariate Analysis, Prefrontal Cortex diagnostic imaging, Psychometrics, Statistics as Topic, Tomography, X-Ray Computed, Authoritarianism, Brain Injuries pathology, Brain Injuries psychology, Prefrontal Cortex physiopathology, Religion
Abstract

Objective: The psychological processes of doubting and skepticism have recently become topics of neuroscientific investigation. In this context, we developed the False Tagging Theory, a neurobiological model of the belief and doubt process, which proposes that the prefrontal cortex is critical for normative doubt regarding properly comprehended cognitive representations. Here, we put our theory to an empirical test, hypothesizing that patients with prefrontal cortex damage would have a doubt deficit that would manifest as higher authoritarianism and religious fundamentalism., Method: Ten patients with bilateral damage to the ventromedial prefrontal cortex (vmPFC), 10 patients with damage to areas outside the vmPFC, and 16 medical comparison patients, who experienced life-threatening (but non-neurological) medical events, completed a series of scales measuring authoritarianism, religious fundamentalism, and specific religious beliefs., Results: vmPFC patients reported significantly higher authoritarianism and religious fundamentalism than the other groups. The degrees of authoritarianism and religious fundamentalism in the vmPFC group were significantly higher than normative values, as well; by contrast, the comparison groups did not differ from normative values. Moreover, vmPFC patients reported increased specific religious beliefs after brain injury., Conclusions: The findings support the False Tagging Theory and suggest that the vmPFC is critical for psychological doubt and resistance to authoritarian persuasion.

Published
2012
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137. Dimensions of personality disturbance after focal brain damage: investigation with the Iowa Scales of Personality Change.

Author

Barrash J, Asp E, Markon K, Manzel K, Anderson SW, and Tranel D

Subjects
Adult, Aged, Brain Injuries pathology, Cognition Disorders etiology, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mood Disorders etiology, Neuropsychological Tests, Personality Disorders classification, Prefrontal Cortex pathology, Principal Component Analysis, Social Behavior, Statistics, Nonparametric, Brain Injuries complications, Personality Assessment, Personality Disorders diagnosis, Personality Disorders etiology, Psychometrics
Abstract

This study employed a multistep, rational-empirical approach to identify dimensions of personality disturbance in brain-damaged individuals: (a) Five dimensions were hypothesized based on empirical literature and conceptual grounds; (b) principal components analysis was performed on the Iowa Scales of Personality Change (ISPC) to determine the pattern of covariance among 30 personality characteristics; (c) when discrepancies existed between principal components analysis results and conceptually based dimensions, empirical findings and clinical considerations were weighed to determine assignment of ISPC scales to dimensions; (d) the fit of data to the refined dimensions was assessed by examination of intercorrelations; (e) differential predictions concerning the relationship of dimensions to ventromedial prefrontal cortex (vmPFC) damage were tested. This process resulted in the specification of five dimensions: Disturbed Social Behavior, Executive/Decision-Making Deficits, Diminished Motivation/Hypo-Emotionality, Irascibility, and Distress. In accord with predictions, the 28 participants with vmPFC lesions, compared to 96 participants with focal lesions elsewhere in the brain, had significantly more Disturbed Social Behavior and Executive/Decision-Making Deficits and tended to have more Diminished Motivation/Hypo-Emotionality. Irascibility was not significantly higher among the vmPFC group, and the groups had very similar levels of Distress. The findings indicate that conceptually distinctive dimensions with differential relationships to vmPFC can be derived from the Iowa Scales of Personality Change.

Published
2011
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138. When "don't worry" communicates fear: Children's perceptions of parental reassurance and distraction during a painful medical procedure.

Author

McMurtry MC, Chambers CT, McGrath PJ, and Asp E

Subjects
Adaptation, Psychological, Adult, Analysis of Variance, Child, Child, Preschool, Facial Expression, Fear psychology, Female, Humans, Male, Pain Measurement, Statistics, Nonparametric, Stress, Psychological psychology, Pain psychology, Parent-Child Relations, Phlebotomy psychology, Social Perception
Abstract

Children's distress during painful medical procedures is strongly influenced by adult behavior. Adult reassurance (e.g., "it's okay") is associated with increased child distress whereas distraction is associated with increased child coping. It is unknown why reassurance shows this counterintuitive relationship with child distress. The present research investigated whether children perceive their parents as fearful when they reassure using complementary observational and experimental methodologies. One hundred children (40 boys, 60 girls) 5-10years old (M=8.02, SD=1.69) and their parents (86 mothers, 14 fathers) participated. First, spontaneous parent-child interactions during pediatric venipuncture were captured and used for a video-mediated recall task in which the children viewed instances of parental reassurance and distraction and rated their parents' fear and happiness. Second, the children were asked to rate the intensity of parental fear and happiness for 12 video vignettes showing an actor posing as a parent during venipuncture. To determine whether the children's perceptions varied with the qualities of the behavior, the vignettes manipulated: facial expression (happy vs. fearful), vocal tone (rising vs. falling), and content (informative reassurance vs. uninformative reassurance vs. distraction). For both tasks, the children provided higher ratings of fear during reassurance than distraction. In response to the vignettes, the children gave higher ratings of parental fear for a fearful facial expression, but the influence of vocal tone differed with the verbal content of the utterance. The results provide insight into the complexity of adult reassurance and highlight the important role of parental facial expression, tone, and verbal content during painful medical procedures., (Copyright 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.)

Published
2010
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139. Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.

Author

Asp E, Nilsson D, and Sunnerhagen P

Subjects
Chromatography, Affinity, Electrophoresis, Gel, Two-Dimensional, Eukaryotic Initiation Factor-2 genetics, Eukaryotic Initiation Factor-3 genetics, Fungal Proteins genetics, Immunoprecipitation, Mitogen-Activated Protein Kinases genetics, Nitrogen deficiency, Osmotic Pressure, Oxidative Stress, Phosphorylation, Polyribosomes, Schizosaccharomyces genetics, Schizosaccharomyces growth & development, Schizosaccharomyces pombe Proteins genetics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Eukaryotic Initiation Factor-2 metabolism, Eukaryotic Initiation Factor-3 metabolism, Fungal Proteins metabolism, Mitogen-Activated Protein Kinases metabolism, Protein Biosynthesis, Schizosaccharomyces metabolism, Schizosaccharomyces pombe Proteins metabolism
Abstract

Signaling by stress-activated mitogen-activated protein kinase (MAPK) pathways influences translation efficiency in mammalian cells and budding yeast. We have investigated the stress-activated MAPK from fission yeast, Sty1, and its downstream protein kinase, Mkp1/Srk1, for physically associated proteins using tandem affinity purification tagging. We find Sty1, but not Mkp1, to bind to the translation elongation factor eukaryotic elongation factor 2 (eEF2) and the translation initiation factor eukaryotic initiation factor 3a (eIF3a). The Sty1-eIF3a interaction is weakened under oxidative or hyperosmotic stress, whereas the Sty1-eEF2 interaction is stable. Nitrogen deprivation causes a transient strengthening of both the Sty1-eEF2 and the Sty1-Mkp1 interactions, overlapping with the time of maximal Sty1 activation. Analysis of polysome profiles from cells under oxidative stress, or after hyperosmotic shock or nitrogen deprivation, shows that translation in sty1 mutant cells recovers considerably less efficiently than that in the wild type. Cells lacking the Sty1-regulated transcription factor Atf1 are deficient in maintaining and recovering translational activity after hyperosmotic shock but not during oxidative stress or nitrogen starvation. In cells lacking Sty1, eIF3a levels are decreased, and phosphorylation of eIF3a is reduced. Taken together, our data point to a central role in translational adaptation for the stress-activated MAPK pathway in fission yeast similar to that in other investigated eukaryotes, with the exception that fission yeast MAPK-activated protein kinases seem not to be directly involved in this process.

Published
2008
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140. Naming dynamic and static actions: neuropsychological evidence.

Author

Tranel D, Manzel K, Asp E, and Kemmerer D

Subjects
Adult, Aged, Aged, 80 and over, Brain Diseases etiology, Dominance, Cerebral physiology, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Names, Nonlinear Dynamics, Reaction Time physiology, Brain Diseases physiopathology, Brain Mapping, Cognition physiology, Neuropsychological Tests statistics & numerical data, Pattern Recognition, Visual physiology
Abstract

There has been considerable interest in identifying the neural correlates of action naming, but the bulk of previous work on this topic has utilized static stimuli. Recent research comparing the visual processing of dynamic versus static actions suggests that these two types of stimuli engage largely overlapping neural systems, raising the possibility that the higher-order processing requirements for naming dynamic and static actions might not be very different. To explore this issue in greater depth, we developed the Dynamic Action Naming Test (DANT), which consists of 158 video clips 3-5s in length, for each of which the participant is asked to produce the most appropriate verb. We administered the DANT to 78 brain-damaged patients drawn from our Patient Registry, and to a demographically matched group of 50 normal participants. Out of the 16 patients who performed defectively on the DANT, nearly all (15/16) had damage in the left hemisphere. Lesion analysis indicated that the frontal operculum was the most frequent area of damage in the 15 patients; also, damage to the posterolateral temporal-occipital sector (in and near MT) was specifically related to defective dynamic action naming. Most of the brain-damaged participants (n=71) also received our Static Action Naming Test (SANT), and we found that performances on verb items that were common across the DANT and SANT were highly correlated (R=.91). Moreover, patients who failed the DANT almost invariably also failed the SANT. These findings lend further support to the hypothesis that there is considerable commonality in the neural systems underlying the use of verbs to orally name dynamic and static actions, a conclusion that is in turn compatible with the concept of "representational momentum". Our results also contribute more generally to the rapidly growing field of research on embodied cognition.

Published
2008
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141. Effect of galantamine on verbal repetition in AD: a secondary analysis of the VISTA trial.

Author

Rockwood K, Fay S, Jarrett P, and Asp E

Subjects
Aged, Aged, 80 and over, Alzheimer Disease drug therapy, Communication Disorders etiology, Diagnostic Imaging, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Neuropsychological Tests, Severity of Illness Index, Treatment Outcome, Video Recording, Alzheimer Disease complications, Cholinesterase Inhibitors therapeutic use, Communication Disorders drug therapy, Galantamine therapeutic use
Abstract

Objectives: To understand how commonly diminution of verbal repetition was a goal of treatment in patients with Alzheimer disease (AD), how commonly that goal was achieved, whether goal attainment might be attributable to galantamine treatment, and whether change in verbal repetition is a marker of the overall treatment response., Methods: This is a secondary analysis of the Video-Imaging Synthesis of Treating Alzheimer's Disease study, a 4-month, double-blind, randomized, placebo-controlled trial of galantamine in 130 community-dwelling patients with mild to moderate AD. The primary outcome was Goal Attainment Scaling, in which individualized problems identified by patients/caregivers and treating physicians were assessed bimonthly., Results: Reduction of verbal repetition was set as a treatment goal in 44% (n = 57) of randomized patients. More patients/caregivers (32%) set repetition goals than did physicians (18%). After 4 months, more galantamine-treated patients showed diminution of verbal repetition (58%) than did placebo-treated patients (24%; p < 0.01). Reduction of verbal repetition correlated with improvement in clinical measures, but not in standardized ones., Conclusions: Reduction of verbal repetition is a common goal of Alzheimer disease treatment. After 4 months, patients treated with galantamine were more likely to experience a reduction of verbal repetition than those treated with placebo. Diminution of verbal repetition was associated with other improvements, suggesting it might be a clinical marker of a positive treatment response.

Published
2007
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142. Parental reassurance and pediatric procedural pain: a linguistic description.

Author

McMurtry CM, McGrath PJ, Asp E, and Chambers CT

Subjects
Adult, Affective Symptoms, Anxiety psychology, Child, Preschool, Father-Child Relations, Female, Humans, Immunization psychology, Male, Mother-Child Relations, Needlestick Injuries psychology, Phonetics, Adaptation, Psychological, Pain psychology, Parents psychology, Verbal Behavior
Abstract

Unlabelled: Certain parental behaviors are associated with child coping and others with child distress when children undergo painful medical procedures. The finding that parental reassurance is linked with increases in child distress is perplexing and counterintuitive. The objective of the present study was to provide a detailed linguistic description of the speech functions and tones parents use when reassuring during painful medical procedures. Videotapes of 28 5-year-old children (12 boys, 16 girls) receiving immunizations who were accompanied by their parents were examined. The majority of reassuring verbalizations were statements; minor clauses (eg, "okay") were the next most frequent type of utterance. Half of the reassuring verbalizations were spoken with a falling tone, which is indicative of speaker certainty and protectiveness. This detailed linguistic approach offers new insights into the qualities of parental reassurance during painful medical procedures. Further research is needed to elucidate the complex interactions of tone, speech function, and reassurance and their effects on child distress., Perspective: This article presents a detailed description of parental reassurance during pediatric immunizations. The description of the linguistic qualities of reassurance can help inform future research examining which characteristics of reassurance are associated with child distress and can help guide parental behavior during immunizations.

Published
2007
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143. Verbal repetition in patients with Alzheimer's disease who receive donepezil.

Author

Asp E, Cloutier F, Fay S, Cook C, Robertson ML, Fisk J, Dei DW, and Rockwood K

Subjects
Aged, Aged, 80 and over, Alzheimer Disease psychology, Cognition Disorders drug therapy, Cognition Disorders etiology, Donepezil, Female, Follow-Up Studies, Humans, Male, Memory, Short-Term, Nootropic Agents therapeutic use, Psychiatric Status Rating Scales, Treatment Outcome, Alzheimer Disease drug therapy, Cholinesterase Inhibitors therapeutic use, Indans therapeutic use, Piperidines therapeutic use, Verbal Behavior drug effects
Abstract

Background: Current outcome measures for Alzheimer's disease (AD) drugs have been criticized as insufficiently patient-centred. One commonly unmeasured goal of patients and caregivers is verbal repetition., Objectives: We examined how often reducing repetition (of questions, statements or stories) was set as treatment goal, whether and when it responded, and how change in repetition correlated with change in other domains., Methods: This is a secondary analysis of the open-label Atlantic Canada Alzheimer's Disease Investigation of Expectations study of donepezil for mild-moderate AD in 100 community-dwelling people. Goal Attainment Scaling, an individualized account of the goals of treatment, was the primary outcome measure., Results: Reducing repetition was a treatment goal in 46%, who were not systematically different from others. Of 18 patients in whom repetition improved for 9 months, 83% (15) showed a response at 3 months. Early (3-month) response correlated best with the overall level of goal attainment (r = 0.74) and changes in leisure activities (r = 0.69) and social interactions (r = 0.68) compared with changes in cognition (r = 0.44) or behaviour (r = 0.11). Correlations with the ADAS-Cog and MMSE change scores remained only modest (at 12 months = -0.25 and 0.19, respectively). Correlations with the CIBIC-Plus were higher (-0.47 at 3 months and -0.43 at 12 months)., Conclusion: Diminution of repetition is common, and appears to mark response to cholinesterase inhibition in some patients. Responders generally also show improved cognition and function, perhaps as an aspect of improved executive function.

Published
2006
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144. Self-referential tags in the discourse of people with Alzheimer's disease.

Author

Asp E, Song X, and Rockwood K

Subjects
Aged, Alzheimer Disease drug therapy, Cholinesterase Inhibitors therapeutic use, Humans, Speech, Alzheimer Disease physiopathology, Brain physiopathology, Self Concept, Verbal Behavior
Abstract

In a study of the discourse of 100 people with Alzheimer's disease treated for 12 months with donepezil, we observed that, as a group, they used a form of tag, described here as a self-referential tag (SRT), 14 times more frequently than did caregivers. Patients use SRTs to check propositions dependent on episodic memory as in I haven't seen the doctor recently, have I? and to monitor information flow as in I told you that already, didn't I? Based on criteria developed for distinguishing checking from monitoring tags, we document the type and frequency of patients' SRT use in the ACADIE corpus and analyze these in relation to standard measures of cognitive function (Mini Mental State Exam and Alzheimer's Disease Assessment Scale-cognitive sub-scale) at baseline and 12 months. Patients using monitoring SRTs (N=31), with or without checking SRTs, show significantly better cognitive test scores at 12 months, than are seen in patients who never use tags (N=29), or who only use checking tags (N=40). SRT use may be an independent measure of potential treatment responsiveness.

Published
2006
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145. Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1.

Author

Asp E and Sunnerhagen P

Subjects
Amino Acid Sequence, Conjugation, Genetic, Fungal Proteins, Genes, Fungal, Intracellular Signaling Peptides and Proteins, Meiosis, Mitogen-Activated Protein Kinases genetics, Mitosis, Models, Biological, Molecular Sequence Data, Mutation, Nitrogen metabolism, Phosphorylation, Protein Serine-Threonine Kinases genetics, Saccharomyces cerevisiae enzymology, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins, Schizosaccharomyces cytology, Schizosaccharomyces genetics, Sequence Homology, Amino Acid, Species Specificity, Mitogen-Activated Protein Kinases metabolism, Protein Serine-Threonine Kinases metabolism, Schizosaccharomyces enzymology, Schizosaccharomyces pombe Proteins
Abstract

Mkp1 ( MAPKAP kinase Schizosaccharomyces pombe 1) and Mkp2 are two members from fission yeast of the sub-class of putative MAPK-activated protein kinases in yeasts, the other known members being Rck1 and Rck2 from Saccharomyces cerevisiae. The Mkp1 protein is readily co-immunoprecipitated with Sty1 from S. pombe extracts; Mkp2 shows a weaker interaction with Sty1. In mkp1 mutants, conjugation and meiosis proceed more readily and rapidly than in wild-type cells, in analogy to what was previously found for S. cerevisiae rck1 mutants. Conversely, overexpression of mkp1(+) delays meiosis. Mkp1 is phosphorylated in vivo in a sty1(+)-dependent manner; this modification is removed when cells are starved for nitrogen, a condition that is conducive to entry into stationary phase and meiosis. Overexpression of mkp1(+), like a sty1 mutation, also causes vegetative cells to elongate. The level of Mkp1 phosphorylation drops as cells enter mitosis. We have localised Mkp1 to the cytoplasm, excluded from the nucleus, in vegetative cells. The Mkp1 protein accumulates in zygotic asci and is concentrated within spores. The mkp2(+) gene has no noticeable impact on meiosis. Mkp2 is excluded from the nucleus in vegetative cells, and is concentrated at the septa of dividing cells. Mkp2 does not accumulate in meiotic cells.

Published
2003
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146. Cutaneous surgeons cannot predict blood-thinner status by intraoperative visual inspection.

Author

West SW, Otley CC, Nguyen TH, Phillips PK, Roenigk RK, Byrd DR, Asp E, and Weaver AL

Subjects
Adult, Aged, Aged, 80 and over, Anticoagulants administration & dosage, Aspirin administration & dosage, Aspirin blood, Female, Humans, Male, Middle Aged, Observation, Platelet Aggregation Inhibitors administration & dosage, Predictive Value of Tests, Prospective Studies, Vitamin E administration & dosage, Vitamin E blood, Warfarin administration & dosage, Warfarin blood, Anticoagulants blood, Dermatologic Surgical Procedures, Hemostasis, Surgical, Mohs Surgery, Platelet Aggregation Inhibitors blood
Abstract

Cutaneous surgeons cannot predict blood-thinner status by intraoperative visual inspection. Many surgeons believe they can discern whether a patient is taking an anticoagulant or a platelet inhibitor (blood thinner) by visual inspection of intraoperative oozing. However, there is little objective evidence to support this strongly held belief. The authors' objective was to determine whether visual inspection of intraoperative oozing during cutaneous surgery is accurate in identifying use of blood thinners. Blinded physician evaluators observed intraoperative oozing in 110 patients having cutaneous excisional surgery, rated the amount of oozing, and judged the likelihood that the patient was taking a blood-thinning agent. On the basis of the impressions of the most senior evaluator, 43 patients having used aspirin in the past 14 days or warfarin or vitamin E in the past 2 days, seven were judged as definitely or probably taking blood-thinning agents (sensitivity, 16.3 percent; 95 percent confidence interval, 6.8 to 30.7 percent). Of 67 patients who did not report recent use of a blood-thinning agent, just 11 were judged as definitely or probably taking blood-thinning agents (false-positive rate, 16.4 percent; 95 percent confidence interval, 8.5 to 27.5 percent). The level of training of the physicians doing the judging did not affect diagnostic sensitivity. Only 10 of the 110 patients (9.1 percent) were assessed as exhibiting excessive oozing, and of those, only four (40 percent) were actually taking a blood thinner. Results were similar when only patients who were taking aspirin or warfarin were analyzed. Thus, contrary to a commonly and strongly held belief, visual inspection of intraoperative oozing during cutaneous excisional surgery correlates poorly with blood-thinner use by patients. The data add further evidence that use of blood thinners does not have an objectively measurable adverse effect during cutaneous surgery.

Published
2002
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147. Structure and chromosomal localization of the rat salivary Psp and Smgb genes.

Author

Gupta N, Asp E, Levan G, and Mirels L

Subjects
Animals, Base Sequence, Chromosome Mapping, DNA chemistry, DNA genetics, DNA isolation & purification, Exons, Genetic Linkage, In Situ Hybridization, Fluorescence, Introns, Male, Molecular Sequence Data, Rats, Rats, Sprague-Dawley, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, Transcription, Genetic, Genes genetics, Salivary Glands metabolism, Salivary Proteins and Peptides genetics
Abstract

SMGB and PSP are among the most abundant products of the immature acinar cells in developing rat parotid and submandibular glands and are also products of the sublingual gland serous demilunes. Previous analysis of Smgb and Psp cDNA clones demonstrated a high degree of sequence similarity between the signal peptide-encoding and 3' untranslated regions of these transcripts, although the secreted proteins themselves are more divergent. The current study reports the upstream sequences, genomic organization and localization of the Psp and Smgb genes. Both structural genes contain nine exons and are present at 3q41-3q42, where they are arranged in tandem and separated by 21kb. In addition to the previously observed sequence similarity, Psp and Smgb are highly homologous throughout exon 1 and at 365 of 600bp immediately upstream of the transcription start site. These findings indicate that the Psp and Smgb genes arose by tandem duplication and divergence. The similar neonatal submandibular and parotid gland expression patterns observed for these genes are likely to be due to closely conserved or shared enhancer(s).

Published
2000
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