101. Sulfasalazine-induced pericarditis in a patient with ulcerative colitis without recurrence when switching to mesalazine.
- Author
-
Perrot S, Aslangul E, Szwebel T, Gadhoum H, Romnicianu S, and Le Jeunne C
- Subjects
- Aminosalicylic Acids adverse effects, Colitis, Ulcerative complications, Colitis, Ulcerative drug therapy, Humans, Male, Middle Aged, Recurrence, Sulfasalazine therapeutic use, Aminosalicylic Acids therapeutic use, Colitis, Ulcerative prevention & control, Mesalamine therapeutic use, Pericarditis chemically induced, Sulfasalazine adverse effects
- Abstract
Introduction: Pericarditis is rarely reported in inflammatory bowel disease. Besides its common causes, pericarditis could be related to ulcerative colitis flare or to 5-aminosalicylic acid (5-ASA) treatment., Case Report: We report the case of a patient in whom fever, weight loss and pericarditis developed after 16 years of treatment with sulfasalazine for ulcerative colitis, after increasing the daily dosage from 1 to 3 g., Discussion: The patient recovered after treatment discontinuation and did not exhibit any recurrence of pericarditis when treatment with mesalazine was introduced., Conclusion: In conclusion, if pericarditis occurs in ulcerative colitis patients treated with 5-ASA compounds, the treatment should be considered as a possible cause, even after an increase of the dosage. In this case, discontinuation of the treatment and cautious switch to another 5-ASA compound should be tested.
- Published
- 2007
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