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101. Genome-wide association study identifies five new schizophrenia loci

Author

Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., Clair, D. S., Corvin, A., Gurling, H., Werge, T., Rujescu, D., D. H. R., Pato, C. N., Malhotra, A. K., Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., Hert, M. D., Jönsson, E. G., Bitter, I., O. P. H., Collier, D. A., Tosato, Sarah, Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G., Byerley, W. F., Cahn, W., Cantor, R. M., Carr, V. J., Catts, S. V., Choudhury, K., Cloninger, C. R., Cormican, P., Craddock, N., Danoy, P. A., Datta, S., Haan, L. d., Demontis, D., Dikeos, D., Djurovic, S., Donnelly, P., Donohoe, G., Duong, L., Dwyer, S., Fink Jensen, A., Freedman, R., Freimer, N. B., Friedl, M., Georgieva, L., Giegling, I., Gill, M., Glenthøj, B., Godard, S., Hamshere, M., Hansen, M., Hansen, T., Hartmann, A. M., Henskens, F. A., Hougaard, D. M., Hultman, C. M., Ingason, A., Jablensky, A. V., Jakobsen, K. D., Jay, M., Jürgens, G., Kahn, R. S., Keller, M. C., Kenis, G., Kenny, E., Kim, Y., Kirov, G. K., Konnerth, H., Konte, B., Krabbendam, L., Krasucki, R., Lasseter, V. K., Laurent, C., Lawrence, J., Lencz, T., Lerer, F. B., Liang, K., Lichtenstein, P., Lieberman, J. A., Linszen, D. H., Lönnqvist, J., Loughland, C. M., Maclean, A. W., Maher, B. S., Maier, W., Mallet, J., Malloy, P., Mattheisen, M., Mattingsdal, M., Mcghee, K. A., Mcgrath, J. J., Mcintosh, A., Mclean, D. E., Mcquillin, A., Melle, I., Michie, P. T., Milanova, V., Morris, D. W., Mors, O., Mortensen, P. B., Moskvina, V., Muglia, P., Myin Germeys, I., Nertney, D. A., Nestadt, G., Nielsen, J., Nikolov, I., Nordentoft, M., Norton, N., Nöthen, M. M., O'Dushlaine, C. T., Olincy, A., Olsen, L., O'Neill, F. A., Orntoft, T. F., Owen, M. J., Pantelis, C., Papadimitriou, G., Pato, M. T., Peltonen, L., Petursson, H., Pickard, B., Pimm, J., Pulver, A. E., Puri, V., Quested, D., Quinn, E. M., Rasmussen, H. B., Réthelyi, J. M., Ribble, R., Rietschel, M., Riley, B. P., Ruggeri, Mirella, Schall, U., Schulze, T. G., Schwab, S. G., Scott, R. J., Shi, J., Sigurdsson, E., Silverman, J. M., C. C. A., Stefansson, K., Strange, A., Strengman, E., Stroup, T. S., Suvisaari, J., Terenius, L., Thirumalai, S., Thygesen, J. H., Timm, S., Toncheva, D., Den, E. v., J. v., Os, Winkel, R. v., Veldink, J., Walsh, D., Wang, A. G., Wiersma, D., Wildenauer, D. B., Williams, H. J., Williams, N. M., Wormley, B., Zammit, S., Sullivan, P. F., O'Donovan, M. C., Daly, M. J., Gejman, P. V., Genome Wide, S. P., ANS - Amsterdam Neuroscience, Adult Psychiatry, Functional Genomics, Educational Neuroscience, Clinical Child and Family Studies, Neuroscience Campus Amsterdam - integrative Analysis & Modeling, Neuroscience Campus Amsterdam - Attention & Cognition, LEARN! - Brain, learning and development, Psychiatrie & Neuropsychologie, and RS: MHeNs School for Mental Health and Neuroscience

Subjects
Male, Gene Dosage, Biology, VARIANTS, SUSCEPTIBILITY, ANCESTRY, Polymorphism, Single Nucleotide, Article, Linkage Disequilibrium, White People, 03 medical and health sciences, 0302 clinical medicine, microRNA, Genetics, Humans, Genetic Predisposition to Disease, Alleles, 030304 developmental biology, 0303 health sciences, Genome, Genome, Human, HERITABILITY, MICRORNA, BIPOLAR DISORDER, 3. Good health, schizophrenia, COMMON SNPS EXPLAIN, MicroRNAs, INDIVIDUALS, Logistic Models, Gene Expression Regulation, Haplotypes, LARGE PROPORTION, Genetic Loci, Case-Control Studies, Mutation, Female, HUMAN HEIGHT, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10 -11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10 -9), ANK3 (rs10994359, P = 2.5 × 10 -8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10 -9). © 2011 Nature America, Inc. All rights reserved.

Published
2011

102. Impact of a pharmacist-led palliative care education program focused on the appropriate use of opioids in Vietnam

Author

Trang Nguyen, Christine Do, Annie L Vong, Thuy Hong Do, Camilla Farrell, Trang Dang, The Than, Duong Le, and Khoa Duong

Subjects
palliative care, vietnam, opioids, pharmacist, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441, Pharmaceutical industry, HD9665-9675
Abstract

Providing palliative care service involves ensuring adequate pain control, which may necessitate the use of opioids. Vietnam has a long history of limited availability of opioids, resulting in healthcare providers’ inexperience and discomfort with prescribing them. This leads to unnecessary patients suffering due to undertreatment of pain. This cross-sectional study examined the impact of the first pharmacist-led online education program in a university hospital in Vietnam on learners’ knowledge and perceived confidence in managing opioids for analgesia in the palliative care setting. Participants filled out a voluntary survey utilizing a five-point Likert scale, within one week of completing the program. We used descriptive statistics and multiple linear regression models to analyze the data. Of the 480 participants enrolled, 28.3% completed the post-course survey. On a scale of 1 to 5, participants reported positive scores in all endpoints, with a mean score ranging from 3.57±0.99 to 3.96±0.83. Significant improvement was seen in confidence with using opioids after the course (p

Published
2022
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103. Réhabilitation améliorée après chirurgie urologique : une expérience monocentrique prospective évaluant l’impact sur la durée de séjour et les complications péri- et postopératoires

Author

Fakhfakh, S., primary, Pignot, G., additional, Traumann, M., additional, Tourret, M., additional, Rybikowski, S., additional, Koskas, Y., additional, Duong, L. Nguyen, additional, Cini, E., additional, Blache, J., additional, and Walz, J., additional

Published
2017
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105. The Galah Survey: Classification and Diagnostics with t-SNE Reduction of Spectral Information

Author

Traven, G., primary, Matijevič, G., additional, Zwitter, T., additional, Žerjal, M., additional, Kos, J., additional, Asplund, M., additional, Bland-Hawthorn, J., additional, Casey, A. R., additional, De Silva, G., additional, Freeman, K., additional, Lin, J., additional, Martell, S. L., additional, Schlesinger, K. J., additional, Sharma, S., additional, Simpson, J. D., additional, Zucker, D. B., additional, Anguiano, B., additional, Da Costa, G., additional, Duong, L., additional, Horner, J., additional, Hyde, E. A., additional, Kafle, P. R., additional, Munari, U., additional, Nataf, D., additional, Navin, C. A., additional, Reid, W., additional, and Ting, Y.-S., additional

Published
2017
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106. Towards Live Detection of Cancerous Tissue During Radical Prostatectomy Using a Raman Spectroscopy Probe

Author

Pinto, Michael, primary, Aubertin, K., additional, Desroches, J., additional, Jermyn, M., additional, Trinh, V.Q., additional, Vladoiu, M.C., additional, Grosset, A-A., additional, Lavallee, A. P., additional, Benzyane, I., additional, Faci, N., additional, Richard, M.E., additional, Duong, L., additional, Haas, C., additional, Badawy, Y., additional, Saad, F., additional, Zorn, K., additional, Lesage, F., additional, Leblond, F., additional, and Trudel, D., additional

Published
2017
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107. An economic evaluation of Wolbachia deployments for dengue control in Vietnam.

Author

Hugo C Turner, Duong Le Quyen, Reynold Dias, Phan Thi Huong, Cameron P Simmons, and Katherine L Anders

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

IntroductionDengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control in Vietnam-targeted at the highest burden urban areas.MethodsTen settings within Vietnam were identified as priority locations for potential future Wolbachia deployments (using a population replacement strategy). The effectiveness of Wolbachia deployments in reducing the incidence of symptomatic dengue cases was assumed to be 75%. We assumed that the intervention would maintain this effectiveness for at least 20 years (but tested this assumption in the sensitivity analysis). A cost-utility analysis and cost-benefit analysis were conducted.ResultsFrom the health sector perspective, the Wolbachia intervention was projected to cost US$420 per disability-adjusted life year (DALY) averted. From the societal perspective, the overall cost-effectiveness ratio was negative, i.e. the economic benefits outweighed the costs. These results are contingent on the long-term effectiveness of Wolbachia releases being sustained for 20 years. However, the intervention was still classed as cost-effective across the majority of the settings when assuming only 10 years of benefits.ConclusionOverall, we found that targeting high burden cities with Wolbachia deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains.

Published
2023
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108. Radiation-associated Cardiac Injury

Author

Robert, Eldabaje, Duong L, Le, Wendy, Huang, and Li-Xi, Yang

Subjects
Heart Injuries, Radiotherapy, Cardiovascular Diseases, Risk Factors, Humans, Breast Neoplasms, Female, Radiation Injuries, Hodgkin Disease
Abstract

Chest radiotherapy continues to play an important role in the treatment of breast cancer, Hodgkin's lymphoma, and other malignancies. Subsequent cardiac injury has been described involving essentially all structures of the heart, with most radiation-induced injury being progressive in nature. Our understanding over the multifactorial etiology and development of radiation-associated cardiac injury has advanced, leading to improved techniques aimed at decreasing cardiac radiation exposure and associated risks. Monitoring after radiotherapy clearly appears to be indicated; however, optimal recommendations regarding cardiac screening remain difficult to establish.

Published
2015

109. Review of RFID applications in perishable inventory management

Author

Duong, L., Wood, Lincoln, Wang, X., Duong, L., Wood, Lincoln, and Wang, X.

Abstract

Radio frequency identification (RFID) technology, which enables real time data collection, has been proposed as a promising solution in perishable inventory management. Research shows that RFID technology has many benefits for perishable products; therefore, this chapter presents an overview of RFID technology and its applications to perishable inventory management. The findings provide a comprehensive review and support the managers in evaluating an investment decision to implement RFID and employ RFID in inventory management for perishable products.

Published
2016

110. The muon anomalous magnetic moment and the standard model

Author

Hertzog, David W., Carey, R. M., Efstathiadis, E., Hare, M. F., Huang, X., Krienen, F., Lam, A., Logashenko, I., Miller, J. P., Paley, J., Peng, Q., Rind, O., Roberts, B. L., Sulak, L. R., Trofimov, A., Bennett, G. W., Brown, H. N., Bunce, G., Danby, G. T., Larsen, R., Lee, Y. Y., Meng, W., Mi, J., Morse, W. M., Nikas, D., Özben, C., Prigl, R., Semertzidis, Y. K., Warburton, D., Orlov, Y., Grossmann, A., zu Putlitz, G., von Walter, P., Debevec, P. T., Deninger, W., Gray, F. E., Onderwater, C. J G, Polly, C., Sossong, M., Urner, D., Yamamoto, A., Jungmann, K., Bousquet, B., Cushman, P., Duong, L., Giron, S., Kindem, J., Kronkvist, I., McNabb, R., Qian, T., Shagin, P., Druzhinin, V. P., Fedotovich, G. V., Grigoriev, D., Khazin, B. I., Ryskulov, N. M., Shatunov, Yu M., Solodov, E., Iwasaki, I., Deng, H., Deile, M., Dhawan, S. K., Farley, F. J M, Hughes, V. W., Kawall, D., Perdekamp, M. Grosse, Pretz, J., Redin, S. I., Sichtermann, E., Steinmetz, A., and Precision Frontier

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Anomalous magnetic dipole moment, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Anomaly (physics), Nuclear Experiment, Standard Model
Abstract

The muon anomalous magnetic moment measurement, when compared with theory, can be used to test many extensions to the standard model. The most recent measurement made by the Brookhaven E821 Collaboration reduces the uncertainty on the world average of a_mu to 0.7 ppm, comparable in precision to theory. This paper describes the experiment and the current theoretical efforts to establish a correct standard model reference value for the muon anomaly., Plenary Talk; PANIC'02 XVI Particles and Nuclear International Conference, Osaka, Japan; Sept. 30 - Oct. 4, 2002; Report describes the published 0.7 ppm result and updates the theory status

Published
2003

111. Cardiotoxicity of molecular-targeted drug therapy

Author

Duong L, Le, Huynh, Cao, and Li-Xi, Yang

Subjects
Heart Diseases, Animals, Humans, Antineoplastic Agents, Molecular Targeted Therapy
Abstract

Cardiotoxicity is a well-known side-effect described in patients receiving various antineoplastic agents. With the abundance of clinical research and a heavy focus on drug development over the past decade, there has been a major shift in the use of non-specific cytotoxic drugs to molecular-targeted drug therapy. However, as a result, it has become clear that these drugs have numerous adverse effects, both on-target and off-target. Small-molecule tyrosine kinase inhibitors and other molecular-targeted agents, including monoclonal antibodies, have been the primary agents associated with cardiotoxicity. As more molecular-targeted therapies are developed, early recognition and management of drug-related cardiotoxicity will be extremely important in order to reduce morbidity and mortality. Pre-treatment evaluation with a surface electrocardiogram, echocardiography, cardiac history, and comprehensive review of concomitant medications are the current mainstay of treatment. However, much is still unknown about the potential cardiotoxic side-effects of these drug and optimal management. In the present article, we aim to review the cardiovascular implications and related cardiotoxicities associated with molecular target-based chemotherapeutic agents, with special emphasis on hypertension, cardiac dysfunction, and QT prolongation. Their implication, mechanism, and management are discussed where possible.

Published
2014

112. The GALAH survey: observational overview andGaiaDR1 companion

Author

Martell, S. L., primary, Sharma, S., additional, Buder, S., additional, Duong, L., additional, Schlesinger, K. J., additional, Simpson, J., additional, Lind, K., additional, Ness, M., additional, Marshall, J. P., additional, Asplund, M., additional, Bland-Hawthorn, J., additional, Casey, A. R., additional, De Silva, G., additional, Freeman, K. C., additional, Kos, J., additional, Lin, J., additional, Zucker, D. B., additional, Zwitter, T., additional, Anguiano, B., additional, Bacigalupo, C., additional, Carollo, D., additional, Casagrande, L., additional, Da Costa, G. S., additional, Horner, J., additional, Huber, D., additional, Hyde, E. A., additional, Kafle, P. R., additional, Lewis, G. F., additional, Nataf, D., additional, Navin, C. A., additional, Stello, D., additional, Tinney, C. G., additional, Watson, F. G., additional, and Wittenmyer, R., additional

Published
2016
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114. First light results from the High Efficiency and Resolution Multi-Element Spectrograph at the Anglo-Australian Telescope

Author

Sheinis, A, Anguiano, B, Asplund, M, Bacigalupo, C, Barden, S, Birchall, M, Bland-Hawthorn, J, Brzeski, J, Cannon, R, Carollo, D, Case, S, Casey, A, Churilov, V, Warrick, C, Dean, R, De Silva, G, D'Orazi, V, Duong, L, Farrell, T, Fiegert, K, Freeman, K, Gabriella, F, Gers, L, Goodwin, M, Gray, D, Green, A, Heald, R, Heijmans, J, Ireland, M, Jones, D, Kafle, P, Keller, S, Klauser, U, Kondrat, Y, Kos, J, Lawrence, J, Lee, S, Mali, S, Martell, S, Mathews, D, Mayfield, D, Miziarski, S, Muller, R, Pai, N, Patterson, R, Penny, E, Orr, D, Schlesinger, K, Sharma, S, Shortridge, K, Simpson, J, Smedley, S, Smith, G, Stafford, D, Staszak, N, Vuong, M, Waller, L, de Boer, EW, Xavier, P, Zheng, J, Zhelem, R, Zucker, D, Zwitter, T, Sheinis, A, Anguiano, B, Asplund, M, Bacigalupo, C, Barden, S, Birchall, M, Bland-Hawthorn, J, Brzeski, J, Cannon, R, Carollo, D, Case, S, Casey, A, Churilov, V, Warrick, C, Dean, R, De Silva, G, D'Orazi, V, Duong, L, Farrell, T, Fiegert, K, Freeman, K, Gabriella, F, Gers, L, Goodwin, M, Gray, D, Green, A, Heald, R, Heijmans, J, Ireland, M, Jones, D, Kafle, P, Keller, S, Klauser, U, Kondrat, Y, Kos, J, Lawrence, J, Lee, S, Mali, S, Martell, S, Mathews, D, Mayfield, D, Miziarski, S, Muller, R, Pai, N, Patterson, R, Penny, E, Orr, D, Schlesinger, K, Sharma, S, Shortridge, K, Simpson, J, Smedley, S, Smith, G, Stafford, D, Staszak, N, Vuong, M, Waller, L, de Boer, EW, Xavier, P, Zheng, J, Zhelem, R, Zucker, D, and Zwitter, T

Published
2015

115. The GALAH survey: Scientific motivation

Author

De Silva, GM, Freeman, KC, Bland-Hawthorn, J, Martell, S, Wylie de Boer, E, Asplund, M, Keller, S, Sharma, S, Zucker, DB, Zwitter, T, Anguiano, B, Bacigalupo, C, Bayliss, D, Beavis, MA, Bergemann, M, Campbell, S, Cannon, R, Carollo, D, Casagrande, L, Casey, AR, Da Costa, G, D'Orazi, V, Dotter, A, Duong, L, Heger, A, Ireland, MJ, Kafle, PR, Kos, J, Lattanzio, J, Lewis, GF, Lin, J, Lind, K, Munari, U, Nataf, DM, O'Toole, S, Parker, Q, Reid, W, Schlesinger, KJ, Sheinis, A, Simpson, JD, Stello, D, Ting, YS, Traven, G, Watson, F, Wittenmyer, R, Yong, D, Žerjal, M, De Silva, GM, Freeman, KC, Bland-Hawthorn, J, Martell, S, Wylie de Boer, E, Asplund, M, Keller, S, Sharma, S, Zucker, DB, Zwitter, T, Anguiano, B, Bacigalupo, C, Bayliss, D, Beavis, MA, Bergemann, M, Campbell, S, Cannon, R, Carollo, D, Casagrande, L, Casey, AR, Da Costa, G, D'Orazi, V, Dotter, A, Duong, L, Heger, A, Ireland, MJ, Kafle, PR, Kos, J, Lattanzio, J, Lewis, GF, Lin, J, Lind, K, Munari, U, Nataf, DM, O'Toole, S, Parker, Q, Reid, W, Schlesinger, KJ, Sheinis, A, Simpson, JD, Stello, D, Ting, YS, Traven, G, Watson, F, Wittenmyer, R, Yong, D, and Žerjal, M

Abstract

The Galactic Archaeology with HERMES (GALAH) survey is a large high-resolution spectroscopic survey using the newly commissioned High Efficiency and Resolution Multi-Element Spectrograph (HERMES) on the Anglo-Australian Telescope. The HERMES spectrograph provides high-resolution (R ~ 28 000) spectra in four passbands for 392 stars simultaneously over a 2 deg field of view. The goal of the survey is to unravel the formation and evolutionary history of the Milky Way, using fossil remnants of ancient star formation events which have been disrupted and are now dispersed throughout the Galaxy. Chemical tagging seeks to identify such dispersed remnants solely from their common and unique chemical signatures; these groups are unidentifiable from their spatial, photometric or kinematic properties. To carry out chemical tagging, the GALAH survey will acquire spectra for a million stars down to V ~ 14. The HERMES spectra of FGK stars contain absorption lines from 29 elements including light proton-capture elements, α-elements, odd-Z elements, iron-peak elements and n-capture elements from the light and heavy s-process and the r-process. This paper describes the motivation and planned execution of the GALAH survey, and presents some results on the first-light performance of HERMES.

Published
2015

116. A Multi-criteria Inventory Management System for Perishable & Substitutable Products

Author

Duong, L., Wood, Lincoln, Wang, W., Duong, L., Wood, Lincoln, and Wang, W.

Abstract

Perishable products represent a vital area in the retail industry and our daily lives. However, when considered with product substitution (which provides more choices) the short lifetime of perishable products creates significant challenges for the inventory management (e.g., one-third of food products are wasted). The main question is: what is the suitable ‘inventory policy’ when we have products that are both perishable and substitutable? Appropriate performance metrics are proposed to evaluate the whole system and provide a robust solution while also being easy for professionals to understand and adopt. Therefore, this paper proposes to use multi-metric approach, including Order Rate Variance Ratio, Average Inventory, and Fill Rate. The paper extends inventory theory to consider inventory management of products where they possess multi-period lifetime, positive lead time, required customer service level, and each item is treated separately. Under these circumstances, as the first research adopting these easily captured and analysed performance metrics, the proposed model will enable management of realistic scenarios by incorporating multiple inventory characteristics that support cross-functional continuous improvement.

Published
2015

118. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

Author

Aj, Schork, Wk, Thompson, Pham P, Torkamani A, Jc, Roddey, Pf, Sullivan, Jr, Kelsoe, Donovan Mc, O., Furberg H, Tobacco and Genetics Consortium, Bipolar Disorder Psychiatric Genomics Consortium, Schizophrenia Psychiatric Genomics Consortium, Nj, Schork, Oa, Andreassen, Am, Dale, Absher D, Agudo A, Almgren P, Ardissino D, Tl, Assimes, Bandinelli S, Barzan L, Bencko V, Benhamou S, Ej, Benjamin, Bernardinelli L, Bis J, Boehnke M, Boerwinkle E, Di, Boomsma, Brennan P, Canova C, Castellsagué X, Chanock S, Chasman D, Di, Conway, Dackor J, Ej, Geus, Duan J, Elosua R, Everett B, Fabianova E, Ferrucci L, Foretova L, Sp, Fortmann, Franceschini N, Frayling T, Furberg C, Pv, Gejman, Groop L, Gu F, Guralnik J, Se, Hankinson, Haritunians T, Healy C, Hofman A, Holcátová I, Dj, Hunter, Sj, Hwang, Jp, Ioannidis, Iribarren C, Au, Jackson, Janout V, Kaprio J, Kim Y, Kjaerheim K, Jw, Knowles, Kraft P, Ladenvall C, Lagiou P, Lanthrop M, Lerman C, Df, Levinson, Levy D, Md, Li, Dy, Lin, Eh, Lips, Lissowska J, Lowry R, Lucas G, Tv, Macfarlane, Maes H, Pm, Mannucci, Mates D, Mauri F, Ja, Mcgovern, Jd, Mckay, McKnight B, Melander O, Pa, Merlini, Milaneschi Y, Kl, Mohlke, Donnell Cj, O., Pare G, Bw, Penninx, Perry J, Posthuma D, Sr, Preis, Psaty B, Quertermous T, Vs, Ramachandran, Richiardi L, Ridker P, Rose J, Rudnai P, Salomaa V, Ar, Sanders, Sm, Schwartz, Shi J, Jh, Smit, Hm, Stringham, Szeszenia-Dabrowska N, Tanaka T, Taylor K, Thacker E, Thornton L, Tiemeier H, Tuomilehto J, Ag, Uitterlinden, Cm, Duijn, Jm, Vink, Vogelzangs N, Bf, Voight, Walter S, Willemsen G, Zaridze D, Znaor A, Akil H, Anjorin A, Backlund L, Ja, Badner, Jd, Barchas, Tb, Barrett, Bass N, Bauer M, Bellivier F, Se, Bergen, Berrettini W, Blackwood D, Cs, Bloss, Breen G, Breuer R, We, Bunner, Burmeister M, Byerley W, Caesar S, Chambert K, Cichon S, St Clair D, Da, Collier, Corvin A, Wh, Coryell, Craddock N, Dw, Craig, Daly M, Day R, Degenhardt F, Djurovic S, Dudbridge F, Hj, Edenberg, Elkin A, Etain B, Ae, Farmer, Ma, Ferreira, Ferrier I, Flickinger M, Foroud T, Frank J, Fraser C, Frisén L, Es, Gershon, Gill M, Gordon-Smith K, Ek, Green, Ta, Greenwood, Grozeva D, Guan W, Gurling H, Ó, Gustafsson, Ml, Hamshere, Hautzinger M, Herms S, Hipolito M, Pa, Holmans, Cm, Hultman, Jamain S, Eg, Jones, Jones I, Jones L, Kandaswamy R, Jl, Kennedy, Gk, Kirov, Dl, Koller, Kwan P, Landén M, Langstrom N, Lathrop M, Lawrence J, Wb, Lawson, Leboyer M, Ph, Lee, Li J, Lichtenstein P, Lin D, Liu C, Fw, Lohoff, Lucae S, Pb, Mahon, Maier W, Ng, Martin, Mattheisen M, Matthews K, Mattingsdal M, Ka, Mcghee, McGuffin P, Mg, Mcinnis, McIntosh A, McKinney R, Aw, Mclean, Fj, Mcmahon, McQuillin A, Meier S, Melle I, Meng F, Pb, Mitchell, Gw, Montgomery, Moran J, Morken G, Dw, Morris, Moskvina V, Muglia P, Tw, Mühleisen, Wj, Muir, Müller-Myhsok B, Rm, Myers, Cm, Nievergelt, Nikolov I, Nimgaonkar V, Mm, Nöthen, Ji, Nurnberger, Ea, Nwulia, O'Dushlaine C, Osby U, Óskarsson H, Mj, Owen, Petursson H, Bs, Pickard, Porgeirsson P, Jb, Potash, Propping P, Sm, Purcell, Quinn E, Raychaudhuri S, Rice J, Rietschel M, Ruderfer D, Schalling M, Af, Schatzberg, Wa, Scheftner, Pr, Schofield, Tg, Schulze, Schumacher J, Mm, Schwarz, Scolnick E, Lj, Scott, Pd, Shilling, Sigurdsson E, Sklar P, En, Smith, Stefansson H, Stefansson K, Steffens M, Steinberg S, Strauss J, Strohmaier J, Szelinger S, Rc, Thompson, Tozzi F, Treutlein J, Jb, Vincent, Sj, Watson, Tf, Wienker, Williamson R, Sh, Witt, Wright A, Xu W, Ah, Young, Pp, Zandi, Zhang P, Zöllner S, Agartz I, Albus M, Alexander M, Rl, Amdur, Amin F, Bitter I, Dw, Black, Ad, Børglum, Ma, Brown, Bruggeman R, Ng, Buccola, Wf, Byerley, Cahn W, Rm, Cantor, Vj, Carr, Sv, Catts, Choudhury K, Cloninger C, Cormican P, Pa, Danoy, Datta S, DeHert M, Demontis D, Dikeos D, Donnelly P, Donohoe G, Duong L, Dwyer S, Fanous A, Fink-Jensen A, Freedman R, Nb, Freimer, Friedl M, Georgieva L, Giegling I, Glenthøj B, Godard S, Golimbet V, de Haan L, Hansen M, Hansen T, Am, Hartmann, Fa, Henskens, Dm, Hougaard, Ingason A, Av, Jablensky, Kd, Jakobsen, Jay M, Eg, Jönsson, Jürgens G, Rs, Kahn, Mc, Keller, Ks, Kendler, Kenis G, Kenny E, Konnerth H, Konte B, Krabbendam L, Krasucki R, Vk, Lasseter, Laurent C, Lencz T, Lerer F, Ky, Liang, Ja, Lieberman, Dh, Linszen, Lönnqvist J, Cm, Loughland, Aw, Maclean, Bs, Maher, Ak, Malhotra, Mallet J, Malloy P, Jj, Mcgrath, McLean DE, Pt, Michie, Milanova V, Mors O, Pb, Mortensen, Bj, Mowry, Myin-Germeys I, Neale B, Da, Nertney, Nestadt G, Nielsen J, Nordentoft M, Norton N, O'Neill F, Olincy A, Olsen L, Ra, Ophoff, Tf, Ørntoft, van Os J, Pantelis C, Papadimitriou G, Cn, Pato, Mt, Pato, Peltonen L, Pickard B, Op, Pietiläinen, Pimm J, Ae, Pulver, Puri V, Digby Quested, Hb, Rasmussen, Jm, Réthelyi, Ribble R, Bp, Riley, Rossin L, Ruggeri M, Rujescu D, Schall U, Sg, Schwab, Rj, Scott, Jm, Silverman, Cc, Spencer, Strange A, Strengman E, Stroup T, Suvisaari J, Terenius L, Thirumalai S, Timm S, Toncheva D, Tosato S, Ej, Den Oord, Veldink J, Pm, Visscher, Walsh D, Ag, Wang, Werge T, Wiersma D, Db, Wildenauer, Hj, Williams, Nm, Williams, van Winkel R, Wormley B., Biological Psychology, Functional Genomics, Educational Neuroscience, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, LEARN! - Social cognition and learning, Biophotonics and Medical Imaging, LEARN! - Brain, learning and development, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, EMGO+ - Mental Health, Neuroscience Campus Amsterdam - Brain Imaging Technology, LaserLaB - Biophotonics and Microscopy, ANS - Amsterdam Neuroscience, Adult Psychiatry, Psychiatry, Human genetics, Epidemiology and Data Science, NCA - Brain mechanisms in health and disease, NCA - Neurobiology of mental health, EMGO - Mental health, NCA - Brain imaging technology, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Gibson, Greg, Germeys, Inez, van Winkel, Ruud, and De Hert, Marc

Subjects
False discovery rate, Netherlands Twin Register (NTR), Cancer Research, Linkage disequilibrium, Genome-wide association study, Linkage Disequilibrium, 0302 clinical medicine, 2.1 Biological and endogenous factors, Aetiology, Genetics (clinical), Genetics, 0303 health sciences, Statistics, Genomics, Single Nucleotide, Genome Scans, Tobacco and Genetics Consortium, Functional Genomics, Phenotype, complex trait, Research Article, Bipolar Disorder Psychiatric Genomics Consortium, lcsh:QH426-470, SNP, Single-nucleotide polymorphism, Computational biology, Biostatistics, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, "genome-wide association study", Genome Analysis Tools, Clinical Research, Schizophrenia Psychiatric Genomics Consortium, Genome-Wide Association Studies, Humans, Genetic Predisposition to Disease, Statistical Methods, Polymorphism, Molecular Biology, Genetic Association Studies, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Genetic association, Linkage (software), Human Genome, Computational Biology, Human Genetics, Heritability, R1, schizophrenia, lcsh:Genetics, Schizophrenia, Mathematics, 030217 neurology & neurosurgery, Genome-Wide Association Study, Developmental Biology
Abstract

Recent results indicate that genome-wide association studies (GWAS) have the potential to explain much of the heritability of common complex phenotypes, but methods are lacking to reliably identify the remaining associated single nucleotide polymorphisms (SNPs). We applied stratified False Discovery Rate (sFDR) methods to leverage genic enrichment in GWAS summary statistics data to uncover new loci likely to replicate in independent samples. Specifically, we use linkage disequilibrium-weighted annotations for each SNP in combination with nominal p-values to estimate the True Discovery Rate (TDR = 1−FDR) for strata determined by different genic categories. We show a consistent pattern of enrichment of polygenic effects in specific annotation categories across diverse phenotypes, with the greatest enrichment for SNPs tagging regulatory and coding genic elements, little enrichment in introns, and negative enrichment for intergenic SNPs. Stratified enrichment directly leads to increased TDR for a given p-value, mirrored by increased replication rates in independent samples. We show this in independent Crohn's disease GWAS, where we find a hundredfold variation in replication rate across genic categories. Applying a well-established sFDR methodology we demonstrate the utility of stratification for improving power of GWAS in complex phenotypes, with increased rejection rates from 20% in height to 300% in schizophrenia with traditional FDR and sFDR both fixed at 0.05. Our analyses demonstrate an inherent stratification among GWAS SNPs with important conceptual implications that can be leveraged by statistical methods to improve the discovery of loci., Author Summary Modern genome-wide association studies (GWAS) have failed to identify large portions of the genetic basis of common, complex traits. Recent work suggested this could be because many genetic variants, each with individually small effects, compose their genetic architecture, limiting the power of GWAS. Moreover, these variants appear more abundantly in and near genes. Using genome annotations, summary statistics from several of the largest GWAS, and established statistical methods for quantifying distributions of test statistics, we show a consistency across studies. Namely, we show that, across all assessed traits, the test statistics resulting from SNPs that are related to the 5′ UTR of genes show the largest abundance of associations, while SNPs related to exons and the 3′UTR are also enriched. SNPs related to introns are only moderately enriched, and intergenic SNPs show a depletion of associations relative to the average SNP. This enrichment corresponds directly to increased replication across independent samples and can be incorporated a priori into statistical methods to improve discovery and prediction. Our results contribute to on-going debates about the functional nature of the genetic architecture of complex traits and point to avenues for leveraging existing GWAS data for discovery in future GWA and sequencing studies.

Published
2013

119. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

Author

Terwisscha van Scheltinga, Af, Bakker, Sc, van Haren, Ne, Derks, Em, Buizer Voskamp, Je, Boos, Hb, Cahn, W, Hulshoff, Pol, Ripke, S, Ophoff, Ra, Kahn, Rs, Sanders, Ar, Kendler, Ks, Levinson, Df, Sklar, P, Holmans, Pa, Lin, Dy, Duan, J, Andreassen, Oa, Scolnick, E, Cichon, S, Clair, St, D, Corvin, A, Gurling, H, Werge, T, Rujescu, D, Blackwood, Dh, Pato, Cn, Malhotra, Ak, Purcell, S, Dudbridge, F, Neale, Bm, Rossin, L, Visscher, Pm, Posthuma, D, Ruderfer, Dm, Fanous, A, Stefansson, H, Steinberg, S, Mowry, Bj, Golimbet, V, Hert, De, M, Jonsson, Eg, Bitter, I, Pietiläinen, Op, Collier, Da, Tosato, Sarah, Agartz, I, Albus, M, Alexander, M, Amdur, Rl, Amin, F, Bass, N, Bergen, Se, Black, Dw, Børglum, Ad, Brown, Ma, Bruggeman, R, Buccola, Ng, Byerley, Wf, Cantor, Rm, Carr, Vj, Catts, Sv, Choudhury, K, Cloninger, C, Cormican, P, Craddock, N, Danoy, Pa, Datta, S, Haan, De, L, Demontis, D, Dikeos, D, Djurovic, S, Donnelly, P, Donohoe, G, Duong, L, Dwyer, S, Fink Jensen, A, Freedman, R, Freimer, Nb, Friedl, M, Georgieva, L, Giegline, I, Gill, M, Glenthøj, B, Godard, S, Hamshere, M, Hansen, M, Hansen, T, Hartmann, Am, Henskens, Fa, Hougaard, Dm, Hultman, Cm, Ingason, A, Jablensky, Av, Jakobsen, Kd, Jay, M, Jürgens, G, Keller, Mc, Kenis, G, Kenny, E, Kim, Y, Kirov, Gk, Konnerth, H, Konte, B, Krabbendam, L, Krasucki, R, Lasseter, Vk, Laurent, C, Lawrence, J, Lencz, T, Lerer, F, Liang, Ky, Lichtenstein, P, Lieberman, Ja, Linszen, Dh, Lönnqvist, J, Loughland, Cm, Maclean, Aw, Maher, Bs, Maier, W, Mallet, J, Malloy, P, Mattheisen, M, Mattingsdal, M, Mcghee, Ka, Mcgrath, Jj, Mcintosh, A, Mclean, De, Mcquillin, A, Melle, I, Michie, Pt, Milanova, V, Morris, Dw, Mors, O, Mortensen, Pb, Moskvina, V, Muglia, P, Myin Germeys, I, Nertney, Da, Nestadt, G, Nielsen, J, Nikolov, I, Nordentoft, M, Norton, N, Nöthen, Mm, O'Dushlaine, C, Olincy, A, Olsen, L, O'Neill, F, Ørntoft, Tf, Owen, Mj, Pantelis, C, Papadimitriou, G, Pato, Mt, Peltonen, L, Petursson, H, Pickard, B, Pimm, J, Pulver, Ae, Puri, V, Quested, D, Quinn, Em, Rasmussen, Hb, Réthelyi, Jm, Ribble, R, Rietschel, M, Riley, Bp, Ruggeri, Mirella, Schall, U, Schulze, Tg, Schwab, Sg, Scott, Rj, Shi, J, Sigurdsson, E, Silverman, Jm, Spencer, Cc, Stefansson, K, Strange, A, Strengman, E, Stroup, Ts, Suvisaari, J, Terenius, L, Thirumalai, S, Thygesen, Jh, Timm, S, Toncheva, D, van den Oord, E, van Os, J, Van, Winkel, R, Veldink, J, Walsh, D, Wang, Ag, Wiersma, D, Wildenauer, Db, Williams, Hj, Williams, Nm, Wormley, B, Zammit, S, Sullivan, Pf, O'Donovan, Mc, Daly, Mj, Gejman, Pv, ANS - Amsterdam Neuroscience, APH - Amsterdam Public Health, Adult Psychiatry, Functional Genomics, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Myin-Germeys, Inez, De Hert, Marc, and van Winkel, Ruud

Subjects
Adult, Male, Psychosis, Genotype, Single-nucleotide polymorphism, Genome-wide association study, Biology, Nerve Fibers, Myelinated, Polymorphism, Single Nucleotide, Article, White matter, genome-wide, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, mental disorders, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Biological Psychiatry, structural MRI, Genetics, neuroimaging, Case-control study, Brain, imaging, medicine.disease, 030227 psychiatry, 3. Good health, schizophrenia, Endophenotype, Phenotype, medicine.anatomical_structure, psychiatric, Schizophrenia, Case-Control Studies, Female, endophenotype, Genome-Wide Association Study, SNPs, Atrophy, 030217 neurology & neurosurgery
Abstract

BACKGROUND: Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume. METHODS: Odds ratios for genome-wide SNP data were calculated in the sample collected by the Psychiatric Genome-wide Association Study Consortium (8690 schizophrenia patients and 11,831 control subjects, excluding subjects from the present study). These were used to calculate individual polygenic schizophrenia (risk) scores in an independent sample of 152 schizophrenia patients and 142 healthy control subjects with available structural magnetic resonance imaging scans. RESULTS: In the entire group, the polygenic schizophrenia score was significantly associated with total brain volume (R2 = .048, p = 1.6 × 10(-4)) and white matter volume (R2 = .051, p = 8.6 × 10(-5)) equally in patients and control subjects. The number of (independent) SNPs that substantially influenced both disease risk and white matter (n = 2020) was much smaller than the entire set of SNPs that modulated disease status (n = 14,751). From the set of 2020 SNPs, a group of 186 SNPs showed most evidence for association with white matter volume and an explorative functional analysis showed that these SNPs were located in genes with neuronal functions. CONCLUSIONS: These results indicate that a relatively small subset of schizophrenia genetic risk variants is related to the (normal) development of white matter. This, in turn, suggests that disruptions in white matter growth increase the susceptibility to develop schizophrenia.

Published
2013

120. Hepatic hydrothorax

Author

Kiran Baikati, Duong L. Le, Ibrahim I. Jabbour, Shashideep Singhal, and Sury Anand

Subjects
Pharmacology, End Stage Liver Disease, Hydrothorax, Humans, Pharmacology (medical), General Medicine, Portasystemic Shunt, Transjugular Intrahepatic, Pleurodesis, Liver Transplantation
Abstract

Hepatic hydrothorax is defined as a pleural effusion in patients with liver cirrhosis in the absence of cardiopulmonary disease. The estimated prevalence among patients with liver cirrhosis is approximately 5-6%. The pathophysiology involves the passage of ascitic fluid from the peritoneal cavity to the pleural space through diaphragmatic defects. The diagnosis is made from clinical presentation and confirmed by diagnostic thoracentesis with pleural fluid analysis. The initial medical management is sodium restriction and diuretics, but liver transplantation provides the only definitive therapy. For patients who are not transplant candidates and those who await organ availability, other therapeutic modalities that are to be considered include transjugular intrahepatic portosystemic shunt placement, videoassisted thoracoscopic surgery repair, pleurodesis, and vasoconstrictors (eg, octreotide and terlipressin). The primary therapeutic goals are to reduce ascitic fluid production and improve symptoms to bridge the time for liver transplantation.

Published
2012

121. The role of endoscopy in bariatrics: past, present, and future

Author

Shashideep Singhal, Duong L. Le, Sushil Duddempudi, and Sury Anand

Subjects
medicine.medical_specialty, Malabsorption, Bariatrics, Gastroplasty, Gastric restriction, Bariatric Surgery, Endoscopy, Gastrointestinal, Weight loss, Surgical Stapling, medicine, Humans, Botulinum Toxins, Type A, medicine.diagnostic_test, Gastric emptying, business.industry, Mortality rate, Suture Techniques, Surgical procedures, medicine.disease, Endoscopy, Surgery, Obesity, Morbid, Gastric Emptying, Neuromuscular Agents, medicine.symptom, business
Abstract

The exponential increase in the rate of obesity and its associated co-morbidities has increased the demand for bariatric surgery. Over the past few decades, surgical weight reduction by gastric restriction, malabsorption, or a combination of both has been the preferred approach to achieve sustained weight loss in the morbidly obese. Although extremely effective, surgical procedures carry significant complications and risk with mortality rates of 1%. Because of the cost, surgical risk, and complications, there is a demand for less invasive procedures. Endoscopic approaches include placement of endoluminal space-occupying devices, stapling devices to reduce gastric volume, barrier devices to reduce small bowel absorptive area, and methods to regulate gastric emptying. Current and ongoing studies have delivered promising results across many aspects of endoscopic approaches. However, many technical obstacles still exist that have to be resolved with further research before endoscopic bariatrics can be widely deployed. At present the role of endoscopy is well established in preoperative evaluation as well as in recognition and management of many postoperative complications in bariatrics. In this article, we review the current and future endoscopic methods for weight reduction that are either in practice or in testing.

Published
2012

122. Genome-wide association study identifies five new schizophrenia loci

Author

Ripke, S. Sanders, A.R. Kendler, K.S. Levinson, D.F. Sklar, P. Holmans, P.A. Lin, D.-Y. Duan, J. Ophoff, R.A. Andreassen, O.A. Scolnick, E. Cichon, S. St. Clair, D. Corvin, A. Gurling, H. Werge, T. Rujescu, D. Blackwood, D.H.R. Pato, C.N. Malhotra, A.K. Purcell, S. Dudbridge, F. Neale, B.M. Rossin, L. Visscher, P.M. Posthuma, D. Ruderfer, D.M. Fanous, A. Stefansson, H. Steinberg, S. Mowry, B.J. Golimbet, V. De Hert, M. Jönsson, E.G. Bitter, I. Pietiläinen, O.P.H. Collier, D.A. Tosato, S. Agartz, I. Albus, M. Alexander, M. Amdur, R.L. Amin, F. Bass, N. Bergen, S.E. Black, D.W. Børglum, A.D. Brown, M.A. Bruggeman, R. Buccola, N.G. Byerley, W.F. Cahn, W. Cantor, R.M. Carr, V.J. Catts, S.V. Choudhury, K. Cloninger, C.R. Cormican, P. Craddock, N. Danoy, P.A. Datta, S. De Haan, L. Demontis, D. Dikeos, D. Djurovic, S. Donnelly, P. Donohoe, G. Duong, L. Dwyer, S. Fink-Jensen, A. Freedman, R. Freimer, N.B. Friedl, M. Georgieva, L. Giegling, I. Gill, M. Glenthøj, B. Godard, S. Hamshere, M. Hansen, M. Hansen, T. Hartmann, A.M. Henskens, F.A. Hougaard, D.M. Hultman, C.M. Ingason, A. Jablensky, A.V. Jakobsen, K.D. Jay, M. Jürgens, G. Kahn, R.S. Keller, M.C. Kenis, G. Kenny, E. Kim, Y. Kirov, G.K. Konnerth, H. Konte, B. Krabbendam, L. Krasucki, R. Lasseter, V.K. Laurent, C. Lawrence, J. Lencz, T. Lerer, F.B. Liang, K.-Y. Lichtenstein, P. Lieberman, J.A. Linszen, D.H. Lönnqvist, J. Loughland, C.M. MacLean, A.W. Maher, B.S. Maier, W. Mallet, J. Malloy, P. Mattheisen, M. Mattingsdal, M. McGhee, K.A. McGrath, J.J. McIntosh, A. McLean, D.E. McQuillin, A. Melle, I. Michie, P.T. Milanova, V. Morris, D.W. Mors, O. Mortensen, P.B. Moskvina, V. Muglia, P. Myin-Germeys, I. Nertney, D.A. Nestadt, G. Nielsen, J. Nikolov, I. Nordentoft, M. Norton, N. Nöthen, M.M. O'Dushlaine, C.T. Olincy, A. Olsen, L. O'Neill, F.A. Ørntoft, T.F. Owen, M.J. Pantelis, C. Papadimitriou, G. Pato, M.T. Peltonen, L. Petursson, H. Pickard, B. Pimm, J. Pulver, A.E. Puri, V. Quested, D. Quinn, E.M. Rasmussen, H.B. Réthelyi, J.M. Ribble, R. Rietschel, M. Riley, B.P. Ruggeri, M. Schall, U. Schulze, T.G. Schwab, S.G. Scott, R.J. Shi, J. Sigurdsson, E. Silverman, J.M. Spencer, C.C.A. Stefansson, K. Strange, A. Strengman, E. Stroup, T.S. Suvisaari, J. Terenius, L. Thirumalai, S. Thygesen, J.H. Timm, S. Toncheva, D. Van Den Oord, E. Van Os, J. Van Winkel, R. Veldink, J. Walsh, D. Wang, A.G. Wiersma, D. Wildenauer, D.B. Williams, H.J. Williams, N.M. Wormley, B. Zammit, S. Sullivan, P.F. O'Donovan, M.C. Daly, M.J. Gejman, P.V.

Abstract

We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10 -11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10 -9), ANK3 (rs10994359, P = 2.5 × 10 -8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10 -9). © 2011 Nature America, Inc. All rights reserved.

Published
2011

125. The GALAH survey: scientific motivation

Author

De Silva, G. M., primary, Freeman, K. C., additional, Bland-Hawthorn, J., additional, Martell, S., additional, de Boer, E. Wylie, additional, Asplund, M., additional, Keller, S., additional, Sharma, S., additional, Zucker, D. B., additional, Zwitter, T., additional, Anguiano, B., additional, Bacigalupo, C., additional, Bayliss, D., additional, Beavis, M. A., additional, Bergemann, M., additional, Campbell, S., additional, Cannon, R., additional, Carollo, D., additional, Casagrande, L., additional, Casey, A. R., additional, Da Costa, G., additional, D'Orazi, V., additional, Dotter, A., additional, Duong, L., additional, Heger, A., additional, Ireland, M. J., additional, Kafle, P. R., additional, Kos, J., additional, Lattanzio, J., additional, Lewis, G. F., additional, Lin, J., additional, Lind, K., additional, Munari, U., additional, Nataf, D. M., additional, O'Toole, S., additional, Parker, Q., additional, Reid, W., additional, Schlesinger, K. J., additional, Sheinis, A., additional, Simpson, J. D., additional, Stello, D., additional, Ting, Y.-S., additional, Traven, G., additional, Watson, F., additional, Wittenmyer, R., additional, Yong, D., additional, and Žerjal, M., additional

Published
2015
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126. CEO compensation from M&As in Australia

Author

Bugeja, M, Da Silva Rosa, R, Duong, L, Izan, H, and Faff, R

Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMilieux_THECOMPUTINGPROFESSION, ComputingMilieux_PERSONALCOMPUTING, ComputingMilieux_LEGALASPECTSOFCOMPUTING, GeneralLiterature_MISCELLANEOUS
Abstract

This paper investigates the extent to which Australian CEOs are compensated following the completion of mergers and acquisitions (M&A)with reference to the incentive alignment and managerial power perspective. Findings reveal that CEOs of acquiring ?rms receive signi?- cantly higher compensation in the year of completing M&As and one year after. This higher compensation is presented in all forms: bonus only, salary only, salary and bonus, and total compensation. It is also found that the incentive alignment and managerial power approach are not mutually exclusive and they both can have some degrees of explaining the variation of CEO compensation following mergers. We ?nd a positive correlation between CEO compensation and ?rm performance, and some measures of CEOs e?ort and skill in completing the deal. However, we observe that CEOs of bidding ?rms have signi?cantly lower bonus and total compensation if there is any entrenchment in the CEO governance process (i.e. CEO is also a chair of the board, or a member of the nominating committee). This result is sharply opposite to the US evidence (Gristein and Hribar (2004)) where CEO compensation after mergers is signi?cantly driven by CEO power. Overall our ?ndings are more consistent with the predictions of the incentive alignment theory rather than the managerial power theor

Published
2010

128. Improved limit on the muon electric dipole moment

Author

Bennett, G.W., Bousquet, B., Brown, H.N., Bunce, G., Carey, R.M., Cushman, P., Danby, G.T., Debevec, P.T., Deile, M., Deng, H., Deninger, W., Dhawan, S.K., Druzhinin, V.P., Duong, L., Efstathiadis, E., Farley, F.J.M., Fedotovich, G.V., Giron, S., Gray, F.E., Grigoriev, D., Grosse-Perdekamp, M., Grossmann, A., Hare, M.F., Hertzog, D.W., Huang, X., Hughes, V.W., Iwasaki, M., Jungmann, K., Kawall, D., Kawamura, M., Khazin, B.I., Kindem, J., Krienen, F., Kronkvist, I., Lam, A., Larsen, R., Lee, Y.Y., Logashenko, I., McNabb, R., Meng, W., Mi, J., Miller, J.P., Mizumachi, Y., Morse, W.M., Nikas, D., Onderwater, C.J.G., Orlov, Y., Ozben, C.S., Paley, J.M., Peng, Q., Polly, C.C., Pretz, J., Prigl, R., Putlitz, G.Z., Qian, T., Redin, S.I., Rind, O., Roberts, B.L., Ryskulov, N., Sedykh, S., Semertzidis, Y.K., Shagin, P., Shatunov, Y.M., Sichtermann, E.P., Solodov, E., Sossong, M., Steinmetz, A., Sulak, L.R., Timmermans, C., Trofimov, A., Urner, D., von Walter, P., Warburton, D., Winn, D., Yamamoto, A., and Zimmerman, D.

Subjects
Experimental High Energy Physics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Contains fulltext : 75224.pdf (Author’s version preprint ) (Open Access) 18 p.

Published
2009

129. Statistical equations and methods applied to the precision muon (g-2) experiment at BNL

Author

Bennett, G. W., Bousquet, B., Brown, H. N., Bunce, G., Carey, R. M., Cushman, P., Danby, G. T., Debevec, P. T., Deile, M., Deng, H., Deninger, W., Dhawan, S. K., Druzhinin, V. P., Duong, L., Efstathiadis, E., Farley, F. J. M., Fedotovich, G. V., Giron, S., Gray, F., Grigoriev, D., Grosse-Perdekamp, M., Grossmann, A., Hare, M., Hertzog, D. W., Huang, X., Hughes, V. W., Iwasaki, M., Jungmann, K., Kawall, D., Kawamura, M., Khazin, B. I., Kindem, J., Krienen, F., Kronkvist, I., Lam, A., Larsen, R., Lee, Y. Y., Logashenko, I. B., McNabb, R., Meng, W., Mi, J., Miller, J. P., Morse, W. M., Nikas, D., Onderwater, C. T. G., Orlov, Yu. F., Ozben, C., Paley, J., Peng, Q., Polly, C., Pretz, J., Prigl, R., Putlitz, G. Zu, Qian, T., Redin, S. I., Rind, O., Roberts, B. L., Ryskulov, N. M., Sedykh, S., Semertzidis, Y. K., Shagin, P., Shatunov, Yu. M., Sichtermann, E. P., Solodov, E. P., Sossong, M., Steinmetz, A., Sulak, L., Timmermans, C., Trofimov, A., Urner, D., von Walter, P., Warburton, D., Winn, D., Yamamoto, A., Zimmerman, D., and KVI - Center for Advanced Radiation Technology

Subjects
systematic errors, statistical errors, correlations, POSITIVE MUON, set-subset variance, X(2) minimization fit, ANOMALOUS MAGNETIC-MOMENT, bias of fit parameters
Abstract

In the muon (g - 2) experiment at Brookhaven National Laboratory, the spin precession frequency omega(a) is obtained from a standard chi(2) minimization fit applied to the time distribution of decay electrons. The unusually high accuracy (similar to 0.5 ppm) of the experiment puts stringent requirements on the quality of the fit and the level of understanding of the statistical properties of the fitted parameters. We discuss the properties of the fits and their implications on the derived value for omega(a), including estimates of the effect of an imperfect fit function, methods of including additional external information to reduce the error, the effects of splitting the data into many smaller subsets of data, applying different weighting methods to the data using energy information, and various tests of data suitability. (c) 2007 Elsevier B.V. All rights reserved.

Published
2007

130. Maximum nullity and zero forcing of circulant graphs

Author

Duong Linh, Kroschel Brenda K., Riddell Michael, Vander Meulen Kevin N., and Van Tuyl Adam

Subjects
zero forcing, minimum rank, maximum nullity, circulant graph, bipartite graph, graph product, 05c50, 05c75, 05c76, 15a03, Mathematics, QA1-939
Abstract

The zero forcing number of a graph has been applied to communication complexity, electrical power grid monitoring, and some inverse eigenvalue problems. It is well-known that the zero forcing number of a graph provides a lower bound on the minimum rank of a graph. In this paper we bound and characterize the zero forcing number of various circulant graphs, including families of bipartite circulants, as well as all cubic circulants. We extend the definition of the Möbius ladder to a type of torus product to obtain bounds on the minimum rank and the maximum nullity on these products. We obtain equality for torus products by employing orthogonal Hankel matrices. In fact, in every circulant graph for which we have determined these numbers, the maximum nullity equals the zero forcing number. It is an open question whether this holds for all circulant graphs.

Published
2020
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131. Analyse multi-capteurs d'un écoulement décollé turbulent

Author

Hoarau, C., Duong, L., Borée, J., Laumonier, J., Gervais, Y., Valière, J.C., Laboratoire d'Etudes Aérodynamiques (LEA), Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS), and Caton, Samuel

Subjects
[PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics], [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], [SPI.MECA] Engineering Sciences [physics]/Mechanics [physics.med-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

132. First CDMS II WIMP Search Results from the Soudan Underground Laboratory

Author

Akerib, D.S., primary, Armel-Funkhouser, M.S., additional, Attisha, M.J., additional, Baudis, L., additional, Bauer, D.A., additional, Brink, P.L., additional, Bunker, R., additional, Cabrera, B., additional, Caldwell, D.O., additional, Chang, C.L., additional, Crisler, M.B., additional, Cushman, P., additional, Dixon, R., additional, Dragowsky, M.R., additional, Driscoll, D.D., additional, Duong, L., additional, Ferril, R., additional, Filippini, J., additional, Gaitskell, R.J., additional, Holmgren, D., additional, Huber, M.E., additional, Kamat, S., additional, Lu, A., additional, Mahapatra, R., additional, Mandic, V., additional, Meunier, P., additional, Mirabolfathi, N., additional, Nelson, H., additional, Nelson, R., additional, Ogburn, R.W., additional, Perera, T.A., additional, Ramberg, E., additional, Rau, W., additional, Reisetter, A., additional, Ross, R.R., additional, Saab, T., additional, Sadoulet, B., additional, Sander, J., additional, Savage, C., additional, Schnee, R.W., additional, Seitz, D.N., additional, Serfass, B., additional, Sirois, A.J., additional, Sundqvist, K.M., additional, Thompson, J-P.F., additional, Wang, G., additional, Yellin, S., additional, and Young, B.A., additional

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133. The SuperCDMS Experiment

Author

Schnee, R.W., primary, Akerib, D.S., additional, Attisha, M.J., additional, Bailey, C.N., additional, Baudis, L., additional, Bauer, D.A., additional, Brink, P.L., additional, Brusov, P.P., additional, Bunker, R., additional, Cabrera, B., additional, Caldwell, D.O., additional, Chang, C.L., additional, Cooley, J., additional, Crisler, M.B., additional, Cushman, P., additional, Denes, P., additional, Dragowsky, M.R., additional, Duong, L., additional, Filippini, J., additional, Gaitskell, R.J., additional, Golwala, S.R., additional, Grant, D.R., additional, Hennings-Yeomans, R., additional, Holmgren, D., additional, Huber, M.E., additional, Irwin, K., additional, Lu, A., additional, Mahapatra, R., additional, Meunier, P., additional, Mirabolfathi, N., additional, Nelson, H., additional, Ogburn, R.W., additional, Ramberg, E., additional, Reisetter, A., additional, Saab, T., additional, Sadoulet, B., additional, Sander, J., additional, Seitz, D.N., additional, Serfass, B., additional, Sundqvist, K.M., additional, Thompson, J-P.F., additional, Yellin, S., additional, Yoo, J., additional, and Young, B.A., additional

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134. Hepatic Hydrothorax

Author

Baikati, Kiran, primary, Le, Duong L., additional, Jabbour, Ibrahim I., additional, Singhal, Shashideep, additional, and Anand, Sury, additional

Published
2014
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136. Evaluating Capacity Development: Experiences from Research and Development Organizations around the World

Author

Horton, D., Alexaki, A., Bennett-Lartey, S., Brice, K. N., Campilan, D., Carden, F., de Souza Silva, J., Duong, L. T., Khadar, I., Boza, A. M., Muniruzzaman, I. K., Perez, J., Chang, M. S., Vernooy, R., Watts, J., and Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase

Subjects
Institutional capacity building, Capacity building, Evaluative processes
Abstract

Metadata only record Although capacity building has become a prevailing objective of most international research and development projects, its methods and standards of evaluation remain unclear. The authors of this book seek to further the discussion on capacity building evaluation and make recommendations by drawing from a several evaluation studies completed by the International System for National Agricultural Research in the Netherlands in 2000. Additionally, they maintain that evaluative studies should also contribute to the effort to which they pertain by producing relevant products that are useful to the development project itself.

Published
2003

138. Publisher’s Note: Measurement of the positive muon anomalous magnetic moment to 0.7 ppm (vol 89, art no 101804, 2002)

Author

Bennett, GW, Bousquet, B, Brown, HN, Bunce, G, Carey, RM, Cushman, P, Danby, GT, Debevec, PT, Deile, M, Deng, H, Deninger, W, Dhawan, SK, Druzhinin, VP, Duong, L, Efstathiadis, E, Farley, FJM, Fedotovich, GV, Giron, S, Gray, FE, Grigoriev, D, Grosse-Perdekamp, M, Grossmann, A, Hare, MF, Hertzog, DW, Huang, X, Hughes, VW, Iwasaski, M, Jungmann, K, Kawall, D, Khazin, BI, Kindem, J, Krienen, F, Kronkvist, I., Lam, A, Larsen, R, Lee, YY, Logashenko, I., McNabb, R, Meng, W, Mi, J, Miller, JP, Morse, WM, Nikas, D, Onderwater, CJG, Orlov, Y, Ozben, CS, Paley, JM, Peng, Q, Polly, CC, and Pretz, J

Published
2002

139. Environmental Hazard of Polypropylene from Disposable Face Masks Linked to the COVID-19 Pandemic and Its Possible Mitigation Techniques through a Green Approach

Author

Selvakumar Vijayalakshmi, Preethi Gopalsamy, Karnan Muthusamy, Dinesh Kumar Sundarraj, Steffi Pulikondan francis, Thiyagarajan Ramesh, Deog-Hwan Oh, Duong Ly Thi Thuy, Tuyet Thi Anh Truong, Huu Tap Van, and Shankar Karuppannan

Subjects
Chemistry, QD1-999
Abstract

The COVID-19 outbreak again underlined plastic items’ importance in our daily lives. The public has widely utilized disposable face masks constructed of polypropylene polymer materials as effective and inexpensive personal protective equipment (PPE) to inhibit virus transmission. The consequences of this have resulted in millions of tons of plastic garbage littering the environment due to inappropriate disposal and mismanagement. Surgical masks are among them, and this study aimed to assess the biodegrading efficiency of disposable face masks using Pseudomonas aeruginosa VJ 1. This work used a bacterial strain, Pseudomonas aeruginosa VJ 1, obtained from sewage water-contaminated surface soil in Tiruchirappalli, India, to investigate the biodegradation of polypropylene (PP) face masks. The mask pieces were incubated with Pseudomonas aeruginosa VJ 1 culture in three different solid and liquid media for 30 days at 37°C. Surface changes and variations in the intensity of functional groups and carbonyl index variations were confirmed using Field Emission Scanning Electron Microscopy (FE-SEM) and Fourier Transform Infrared Spectroscopy (FTIR) analysis to ensure microbial degradation (up to 5.37% weight reduction of PP films within 30 days). These findings show that Pseudomonas aeruginosa VJ 1 could be a good choice for biodegrading PP masks without harming our health or the environment. There is a need for a novel solution for the degradation of PP. The methods and strain presented here reveal the potential biodegrading agents of PP masks.

Published
2022
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141. CEO Compensation from M&As in Australia

Author

Bugeja, M, Da Silva Rosa, R, Duong, L, Izan, HY, Bugeja, M, Da Silva Rosa, R, Duong, L, and Izan, HY

Abstract

We investigate Australian CEO compensation following mergers and acquisitions (M&As). We find CEOs of acquiring firms receive higher compensation in the year of M&A completion and one year after. We also find a positive correlation between CEO compensation and firm performance, and some measures of CEO effort and skill in completing the deal. However, CEOs of bidding firms receive a lower bonus and other compensation if they wield more managerial power (that is, if the CEO sits on the nominating committee, has a higher level of share ownership, or the board has more executive directors). This result is in sharp contrast to the US where compensation is influenced by CEO power. Overall our findings are more consistent with the predictions of the incentive alignment theory rather than the managerial power theory. © 2012 Blackwell Publishing Ltd.

Published
2012

142. Status of the new muon (g-2) experiment

Author

Nodulman, L, Roberts, B L, Carey, R M, Earle, W, Efstathiadis, E F, Hare, M, Hazen, E S, Krienen, F, Miller, J P, Paley, J M, Rind, O, Sulak, Lawrence R, Trofimov, A V, Brown, H, Brown, H N, Bunce, G M, Danby, G T, Larsen, R, Lee, Y Y, Meng, W, Morse, W M, Pai, C, Prigl, R, Semertzidis, Y K, Warburton, D, Druzhinin, V P, Fedotovich, G V, Khazin, B I, Logashenko, I B, Ryskulov, N M, Shatunov, Yu M, Solodov, E P, Orlov, Yu F, Winn, D, Grossmann, A, Gerhäuser, J, Jungmann, Klaus, zu Putlitz, Gisbert, Debevec, P T, Gray, F, Hertzog, D W, Onderwater, A, Polly, C, Sedykh, S N, Sossong, M, Urner, D, Yamamoto, A, Cushman, P B, Kindem, J, Duong, L, Giron, S, Kronkvist, I J, McNabb, R, Zimmerman, D, Iwasaki, M, Kawamura, M, Deng, H, Dhawan, S K, Farley, Francis J M, Hughes, V W, Kawall, D, Pretz, J, Redin, S I, and Steinmetz, A

Subjects
Detectors and Experimental Techniques
Published
2000

143. New measurement of the anomalous magnetic moment of the positive muon

Author

Carey, RM, Earle, W, Efstathiadis, E, Hare, MF, Hazen, ES, Hughes, BJ, Krienen, F, Miller, JP, Monich, Ouyang, J, Rind, O, Roberts, BL, Sulak, LR, Trofimov, A, Varner, G, Worstell, WA, Benedict, E, Logashenko, I., Benante, J, Brown, HN, Bunce, G, Cullen, J, Danby, GT, Geller, J, Hseuh, H, Jackson, JW, Jia, L, Kochis, S, Larsen, R, Lee, YY, Mapes, M, Meng, W, Morse, WM, Pai, C, Pearson, C, Polk, T., Prigl, R, Rankowitz, S, Sandberg, J, Semertzidis, YK, Shutt, R, Snydstrup, L, Soukas, A, Stillman, A, Tallerico, T, Tanaka, M, Toldo, F, von Lintig, D, Warburton, D, Woodle, K, Chertovskikh, A, Druzhinin, VP, Fedotovich, GV, Grigorev, DN, Golubev, VB, Khazin, BI, Maksimov, A, Merzliakov, Y, Ryskulov, N, Serednyakov, S, Shatunov, YM, Solodov, E, Orlov, Y, Winn, D, Grossmann, A, Gerhaeuser, J, Jungmann, K, von Walter, P, zu Putlitz, G, Bunker, B, Deninger, W, Debevec, PT, Hertzog, DW, Jones, TD, Polly, C, Sedykh, S, Urner, D, Haeberlen, U, Endo, K, Hirabayashi, H, Kurokawa, S, Yamamoto, A, Green, MA, Cushman, P, Kindem, J, Duong, L, Giron, S, McNabb, R, Miller, D, Zimmerman, D, Mizumachi, Y, Iwasaki, M, Ahn, HE, Deng, H, Dhawan, SK, Disco, A, Farley, FJM, Fei, Erkang, Grosse-Perdekamp, M, Hughes, VW, Kawall, D, Redin, SI, Steinmetz, A, and Precision Frontier

Subjects
G-2, Physics::Accelerator Physics, NMR
Abstract

The muon anomalous magnetic moment has been measured in a new experiment at Brookhaven. Polarized muons were stored in a superferric ring, and the angular frequency difference, omega(a), between the spin precession and orbital frequencies was determined by measuring the time distribution of high-energy decay positrons. The ratio R of omega(a) to the Larmor precession frequency of free protons, omega(p), in the storage-ring magnetic field was measured. We find R = 3.707 220(48) X 10(-3). With mu(mu)/mu(p) = 3.183 345 47(47) this gives a(mu+) = 1 165 925(15) X 10(-9) (+/-13 ppm), in good agreement with the previous CERN measurements for mu(+) and mu(-) and of approximately the same precision.

Published
1999

144. CEO compensation from M&As in Australia

Author

Faff, R, Bugeja, M, Da Silva Rosa, R, Duong, L, Izan, H, Faff, R, Bugeja, M, Da Silva Rosa, R, Duong, L, and Izan, H

Abstract

This paper investigates the extent to which Australian CEOs are compensated following the completion of mergers and acquisitions (M&A)with reference to the incentive alignment and managerial power perspective. Findings reveal that CEOs of acquiring ?rms receive signi?- cantly higher compensation in the year of completing M&As and one year after. This higher compensation is presented in all forms: bonus only, salary only, salary and bonus, and total compensation. It is also found that the incentive alignment and managerial power approach are not mutually exclusive and they both can have some degrees of explaining the variation of CEO compensation following mergers. We ?nd a positive correlation between CEO compensation and ?rm performance, and some measures of CEOs e?ort and skill in completing the deal. However, we observe that CEOs of bidding ?rms have signi?cantly lower bonus and total compensation if there is any entrenchment in the CEO governance process (i.e. CEO is also a chair of the board, or a member of the nominating committee). This result is sharply opposite to the US evidence (Gristein and Hribar (2004)) where CEO compensation after mergers is signi?cantly driven by CEO power. Overall our ?ndings are more consistent with the predictions of the incentive alignment theory rather than the managerial power theor

Published
2010

145. Analysis of the low-energy electron-recoil spectrum of the CDMS experiment

Author

Ahmed, Z., Akerib, D. S., Arrenberg, S., Bailey, C. N., Balakishiyeva, D., Baudis, L., Bauer, D. A., Beaty, J., Brink, P. L., Bruch, T., Bunker, R., Cabrera, B., Caldwell, D. O., Cooley, J., Cushman, P., DeJongh, F., Dragowsky, M. R., Duong, L., Figueroa-Feliciano, E., Filippini, J., Fritts, M., Golwala, S. R., Grant, D. R., Hall, J., Hennings-Yeomans, R., Hertel, S., Holmgren, D., Hsu, L., Huber, M. E., Kamaev, O., Kiveni, M., Kos, M., Leman, S. W., Mahapatra, R., Mandic, V., Moore, D., McCarthy, K. A., Mirabolfathi, N., Nelson, H., Ogburn, R. W., Pyle, M., Qiu, X., Ramberg, E., Rau, W., Reisetter, A., Saab, T., Sadoulet, B., Sander, J., Schnee, R. W., Seitz, D. N., Serfass, B., Sundqvist, K. M., Wang, G., Yellin, S., Yoo, J., Young, B. A., Collaboration, the CDMS, Ahmed, Z., Akerib, D. S., Arrenberg, S., Bailey, C. N., Balakishiyeva, D., Baudis, L., Bauer, D. A., Beaty, J., Brink, P. L., Bruch, T., Bunker, R., Cabrera, B., Caldwell, D. O., Cooley, J., Cushman, P., DeJongh, F., Dragowsky, M. R., Duong, L., Figueroa-Feliciano, E., Filippini, J., Fritts, M., Golwala, S. R., Grant, D. R., Hall, J., Hennings-Yeomans, R., Hertel, S., Holmgren, D., Hsu, L., Huber, M. E., Kamaev, O., Kiveni, M., Kos, M., Leman, S. W., Mahapatra, R., Mandic, V., Moore, D., McCarthy, K. A., Mirabolfathi, N., Nelson, H., Ogburn, R. W., Pyle, M., Qiu, X., Ramberg, E., Rau, W., Reisetter, A., Saab, T., Sadoulet, B., Sander, J., Schnee, R. W., Seitz, D. N., Serfass, B., Sundqvist, K. M., Wang, G., Yellin, S., Yoo, J., Young, B. A., and Collaboration, the CDMS

Abstract

We report on the analysis of the low-energy electron-recoil spectrum from the CDMS II experiment using data with an exposure of 443.2 kg-days. The analysis provides details on the observed counting rate and possible background sources in the energy range of 2 - 8.5 keV. We find no significant excess in the counting rate above background, and compare this observation to the recent DAMA results. In the framework of a conversion of a dark matter particle into electromagnetic energy, our 90% confidence level upper limit of 0.246 events/kg/day at 3.15 keV is lower than the total rate above background observed by DAMA by 8.9$\sigma$. In absence of any specific particle physics model to provide the scaling in cross section between NaI and Ge, we assume a Z^2 scaling. With this assumption the observed rate in DAMA differs from the upper limit in CDMS by 6.8$\sigma$. Under the conservative assumption that the modulation amplitude is 6% of the total rate we obtain upper limits on the modulation amplitude a factor of ~2 less than observed by DAMA, constraining some possible interpretations of this modulation., Comment: 4 pages, 3 figures

Published
2009
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146. An Improved Limit on the Muon Electric Dipole Moment

Author

Bennett, G. W., Bousquet, B., Brown, H. N., Bunce, G., Carey, R. M., Cushman, P., Danby, G. T., Debevec, P. T., Deile, M., Deng, H., Deninger, W., Dhawan, S. K., Druzhinin, V. P., Duong, L., Efstathiadis, E., Farley, F. J. M., Fedotovich, G. V., Giron, S., Gray, F. E., Grigoriev, D., Grosse-Perdekamp, M., Grossmann, A., Hare, M. F., Hertzog, D. W., Huang, X., Hughes, V. W., Iwasaki, M., Jungmann, K., Kawall, D., Kawamura, M., Khazin, B. I., Kindem, J., Krienen, F., Kronkvist, I., Lam, A., Larsen, R., Lee, Y. Y., Logashenko, I., McNabb, R., Meng, W., Mi, J., Miller, J. P., Mizumachi, Y., Morse, W. M., Nikas, D., Onderwater, C. J. G., Orlov, Y., Ozben, C. S., Paley, J. M., Peng, Q., Polly, C. C., Pretz, J., Prigl, R., Putlitz, G. zu, Qian, T., Redin, S. I., Rind, O., Roberts, B. L., Ryskulov, N., Sedykh, S., Semertzidis, Y. K., Shagin, P., Shatunov, Yu. M., Sichtermann, E. P., Solodov, E., Sossong, M., Steinmetz, A., Sulak, L. R., Timmermans, C., Trofimov, A., Urner, D., von Walter, P., Warburton, D., Winn, D., Yamamoto, A., Zimmerman, D., Bennett, G. W., Bousquet, B., Brown, H. N., Bunce, G., Carey, R. M., Cushman, P., Danby, G. T., Debevec, P. T., Deile, M., Deng, H., Deninger, W., Dhawan, S. K., Druzhinin, V. P., Duong, L., Efstathiadis, E., Farley, F. J. M., Fedotovich, G. V., Giron, S., Gray, F. E., Grigoriev, D., Grosse-Perdekamp, M., Grossmann, A., Hare, M. F., Hertzog, D. W., Huang, X., Hughes, V. W., Iwasaki, M., Jungmann, K., Kawall, D., Kawamura, M., Khazin, B. I., Kindem, J., Krienen, F., Kronkvist, I., Lam, A., Larsen, R., Lee, Y. Y., Logashenko, I., McNabb, R., Meng, W., Mi, J., Miller, J. P., Mizumachi, Y., Morse, W. M., Nikas, D., Onderwater, C. J. G., Orlov, Y., Ozben, C. S., Paley, J. M., Peng, Q., Polly, C. C., Pretz, J., Prigl, R., Putlitz, G. zu, Qian, T., Redin, S. I., Rind, O., Roberts, B. L., Ryskulov, N., Sedykh, S., Semertzidis, Y. K., Shagin, P., Shatunov, Yu. M., Sichtermann, E. P., Solodov, E., Sossong, M., Steinmetz, A., Sulak, L. R., Timmermans, C., Trofimov, A., Urner, D., von Walter, P., Warburton, D., Winn, D., Yamamoto, A., and Zimmerman, D.

Abstract

Three independent searches for an electric dipole moment (EDM) of the positive and negative muons have been performed, using spin precession data from the muon g-2 storage ring at Brookhaven National Laboratory. Details on the experimental apparatus and the three analyses are presented. Since the individual results on the positive and negative muon, as well as the combined result, d=-0.1(0.9)E-19 e-cm, are all consistent with zero, we set a new muon EDM limit, |d| < 1.9E-19 e-cm (95% C.L.). This represents a factor of 5 improvement over the previous best limit on the muon EDM., Comment: 19 pages, 15 figures, 7 tables

Published
2008
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149. The SuperCDMS Experiment

Author

Klapdor-Kleingrothaus, Hans Volker, Arnowitt, Richard, Schnee, R. W., Akerib, D. S., Attisha, M. J., Bailey, C. N., Baudis, L., Bauer, D. A., Brink, P. L., Brusov, P. P., Bunker, R., Cabrera, B., Caldwell, D. O., Chang, C. L., Cooley, J., Crisler, M. B., Cushman, P., Denes, P., Dragowsky, M. R., Duong, L., Filippini, J., Gaitskell, R. J., Golwala, S. R., Grant, D. R., Hennings-Yeomans, R., Holmgren, D., Huber, M. E., Irwin, K., Lu, A., Mahapatra, R., Meunier, P., Mirabolfathi, N., Nelson, H., Ogburn, R. W., Ramberg, E., Reisetter, A., Saab, T., Sadoulet, B., Sander, J., Seitz, D. N., Serfass, B., Sundqvist, K. M., Thompson, J-P. F., Yellin, S., Yoo, J., Young, B. A., Klapdor-Kleingrothaus, Hans Volker, Arnowitt, Richard, Schnee, R. W., Akerib, D. S., Attisha, M. J., Bailey, C. N., Baudis, L., Bauer, D. A., Brink, P. L., Brusov, P. P., Bunker, R., Cabrera, B., Caldwell, D. O., Chang, C. L., Cooley, J., Crisler, M. B., Cushman, P., Denes, P., Dragowsky, M. R., Duong, L., Filippini, J., Gaitskell, R. J., Golwala, S. R., Grant, D. R., Hennings-Yeomans, R., Holmgren, D., Huber, M. E., Irwin, K., Lu, A., Mahapatra, R., Meunier, P., Mirabolfathi, N., Nelson, H., Ogburn, R. W., Ramberg, E., Reisetter, A., Saab, T., Sadoulet, B., Sander, J., Seitz, D. N., Serfass, B., Sundqvist, K. M., Thompson, J-P. F., Yellin, S., Yoo, J., and Young, B. A.

Abstract

Nonluminous, nonbaryonic, weakly interacting massive particles (WIMPs) [1, 2] may constitute most of the matter in the universe [3]. WIMPs are expected to be in a roughly isothermal Galactic halo. They would interact elastically with nuclei, generating a recoil energy of a few tens of keV, at a rate ≾1 event kg⁻¹ d⁻¹ [2, 4, 5].

Published
2006

150. Beyond the CDMS-II Dark Matter Search: SuperCDMS

Author

Brink, P. L., Cabrera, B., Chang, C. L., Cooley, J., Ogburn, R. W., Akerib, D. S., Bailey, C. N., Brusov, P. P., Dragowsky, M. R., Grant, D. R., Hennings-Yeomans, R., Schnee, R. W., Attisha, M. J., Gaitskell, R. J., Thompson, J-P. F., Baudis, L., Saab, T., Bauer, D. A., Crisler, M. B., Holmgren, D., Ramberg, E., Yoo, J., Bunker, R., Caldwell, D. O., Mahapatra, R., Nelson, H., Sander, J., Yellin, S., Cushman, P., Duong, L., Reisetter, A., Denes, P., Lu, A., Sadoulet, B., Filippini, J., Meunier, P., Mirabolfathi, N., Seitz, D. N., Serfass, B., Sundqvist, K. M., Golwala, S. R., Huber, M. E., Irwin, K. D., Young, B. A., Brink, P. L., Cabrera, B., Chang, C. L., Cooley, J., Ogburn, R. W., Akerib, D. S., Bailey, C. N., Brusov, P. P., Dragowsky, M. R., Grant, D. R., Hennings-Yeomans, R., Schnee, R. W., Attisha, M. J., Gaitskell, R. J., Thompson, J-P. F., Baudis, L., Saab, T., Bauer, D. A., Crisler, M. B., Holmgren, D., Ramberg, E., Yoo, J., Bunker, R., Caldwell, D. O., Mahapatra, R., Nelson, H., Sander, J., Yellin, S., Cushman, P., Duong, L., Reisetter, A., Denes, P., Lu, A., Sadoulet, B., Filippini, J., Meunier, P., Mirabolfathi, N., Seitz, D. N., Serfass, B., Sundqvist, K. M., Golwala, S. R., Huber, M. E., Irwin, K. D., and Young, B. A.

Abstract

Presently the CDMS-II collaboration's Weakly Interacting Massive Particle (WIMP) search at the Soudan Underground Laboratory sets the most stringent exclusion limits of any WIMP cold dark matter direct-detection experiment. To extend our reach further, to WIMP-nucleon cross sections in the range $10^{-46} - 10^{-44}$cm$^2$, we propose SuperCDMS, which would take advantage of a very deep site. One promising site is the recently approved SNOLab facility in Canada. In this paper we will present our overall plan, identify primary issues, and set the goals that need to be met prior to embarking upon each phase of SuperCDMS., Comment: Submitted to Texas Symposium on Relativistic Astrophysics held at Stanford, Dec. 2004. Paper has 6 pages, 4 figures

Published
2005

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