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104. Supreme Court On Evaluation Of Claims To Computer-Implemented Inventions Under 35 U.S.C. § 101

Author

Duncan, Margaret

Subjects
CLS Bank International -- Cases, Alice Corporation Proprietary Ltd. -- Cases, Computer software industry -- Cases, Financial services industry -- Cases, Patent infringement -- Cases, Company legal issue, Financial services industry, Business, international
Abstract

On June 19, 2014, the Supreme Court of the United States issued its much anticipated decision in Alice Corporation Pty. Ltd. v. CLS Bank International et al., confirming that computer-implemented [...]

Published
2014

126. Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis StrainW83

Author

Nelson, Karen E., primary, Fleischmann, Robert D., additional, DeBoy, Robert T., additional, Paulsen, Ian T., additional, Fouts, Derrick E., additional, Eisen, Jonathan A., additional, Daugherty, Sean C., additional, Dodson, Robert J., additional, Durkin, A. Scott, additional, Gwinn, Michelle, additional, Haft, Daniel H., additional, Kolonay, James F., additional, Nelson, William C., additional, Mason, Tanya, additional, Tallon, Luke, additional, Gray, Jessica, additional, Granger, David, additional, Tettelin, Hervé, additional, Dong, Hong, additional, Galvin, Jamie L., additional, Duncan, Margaret J., additional, Dewhirst, Floyd E., additional, and Fraser, Claire M., additional

Published
2004
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134. Paradoxes of the Flesh: Emotion and Contradiction in Fitness/Beauty Magazine Discourse.

Author

Duncan, Margaret Carlisle and Klos, Lori A.

Subjects
*PHYSICAL fitness, *PERSONAL beauty, *REDUCING diets, *WOMEN'S periodicals, *OBESITY, *EPIDEMICS
Abstract

Analyzing women’s fitness/beauty magazines for advice on diet and exercise reveals a range of contradictions, the focus of this research. Contradictory diet and fitness discourses signify our culture’s paradoxical expectations for women’s bodies, ensuring that virtually no woman can measure up. In short, the production of feminine bodies is rigged for failure. Starting with Spitzack’s (1990) initial insights into the “aesthetics of health” and fat as disease, we explicate, through textual analysis, the underlying principles of eight essential contradictions in diet and fitness discourses (e.g., diets are freeing), principles that both necessitate and enable the discursive net in which contemporary women are ensnared. Comparisons are drawn between the themes that Spitzack elaborated and those uncovered by our examination 20 years later. Connections are made to the obesity “epidemic” and implications are discussed. Future research should investigate the actual interpretation and utilization of these contradictory messages among magazine readers. [ABSTRACT FROM PUBLISHER]

Published
2014
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143. IDS Disclosure Not 'Effective' to Limit Claim Terms

Author

Duncan, Margaret and Serauskas, Joy Ann

Subjects
Abbott Laboratories (Abbott Park, Illinois) -- Cases, Abbott Laboratories (Abbott Park, Illinois) -- Intellectual property, Baxter Pharmaceutical Products Inc. -- Cases, Baxter Pharmaceutical Products Inc. -- Intellectual property, Pharmaceutical industry -- Cases, Pharmaceutical industry -- Intellectual property, Disclosure of information, Company legal issue, Business, international
Abstract

Article by Margaret Duncan and Joy Ann Serauskas The U.S. Court of Appeals for the Federal Circuit reversed a finding of non-infringement, finding it based on an improper claim interpretation [...]

Published
2003

149. A Two-Component System Regulates Hemin Acquisition in Porphyromonas gingivalis.

Author

Scott, Jodie C., Klein, Brian A., Duran-Pinedo, Ana, Hu, Linden, and Duncan, Margaret J.

Subjects
HEMIN, GRAM-negative bacteria, ORAL microbiology, PORPHYROMONAS gingivalis infections, CELLULAR signal transduction, COMPARATIVE studies, HISTIDINE kinases
Abstract

Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we discovered that the latter was mutant in histidine kinase (PGN_0752), while the cognate response regulator (PGN_0753) remained intact. Microarray-based transcriptional profiling and ChIP-seq assays were carried out with an ATCC 33277 transconjugant containing the functional histidine kinase from strain W83 (PG0719). The data showed that the regulon of this signal transduction system contained genes that were involved in hemin acquisition, including gingipains, at least three transport systems, as well as being self-regulated. Direct regulation by the response regulator was confirmed by electrophoretic mobility shift assays. In addition, the system appears to be activated by hemin and the regulator acts as both an activator and repressor. [ABSTRACT FROM AUTHOR]

Published
2013
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150. CovR and VicRK Regulate Cell Surface Biogenesis Genes Required for Biofilm Formation in Streptococcus mutans.

Author

Stipp, Rafael N., Boisvert, Heike, Smith, Daniel J., Höfling, José F., Duncan, Margaret J., and Mattos-Graner, Renata O.

Subjects
CELL membranes, ORIGIN of life, STREPTOCOCCUS mutans, BIOFILMS, MICROBIAL virulence, POLYSACCHARIDE synthesis, MOLECULAR genetics, GENETIC regulation, MICROBIOLOGY
Abstract

The two-component system VicRK and the orphan regulator CovR of Streptococcus mutans co-regulate a group of virulence genes associated with the synthesis of and interaction with extracellular polysaccharides of the biofilm matrix. Knockout mutants of vicK and covR display abnormal cell division and morphology phenotypes, although the gene function defects involved are as yet unknown. Using transcriptomic comparisons between parent strain UA159 with vicK (UAvic) or covR (UAcov) deletion mutants together with electrophoretic motility shift assays (EMSA), we identified genes directly regulated by both VicR and CovR with putative functions in cell wall/surface biogenesis, including gbpB, wapE, smaA, SMU.2146c, and lysM. Deletion mutants of genes regulated by VicR and CovR (wapE, lysM, smaA), or regulated only by VicR (SMU.2146c) or CovR (epsC) promoted significant alterations in biofilm initiation, including increased fragility, defects in microcolony formation, and atypical cell morphology and/or chaining. Significant reductions in mureinolytic activity and/or increases in DNA release during growth were observed in knockout mutants of smaA, wapE, lysM, SMU.2146c and epsC, implying roles in cell wall biogenesis. WapE and lysM mutations also affected cell hydrophobicity and sensitivity to osmotic or oxidative stress. Finally, vicR, covR and VicRK/CovR-targets (gbpB, wapE, smaA, SMU.2146c, lysM, epsC) are up-regulated in UA159 during biofilm initiation, in a sucrose-dependent manner. These data support a model in which VicRK and CovR coordinate cell division and surface biogenesis with the extracellular synthesis of polysaccharides, a process apparently required for formation of structurally stable biofilms in the presence of sucrose. [ABSTRACT FROM AUTHOR]

Published
2013
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