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369 results on '"Duarte, Emília"'

104. GDNF: a Key Player in Neuron-Glia Crosstalk and Survival of Nigrostriatal Dopaminergic Neurons.

Author

Malva, João O., Rego, Ana Cristina, Cunha, Rodrigo A., Oliveira, Catarina R., Duarte, Emília P., Saavedra, Ana, and Baltazar, Graça

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for dopaminergic neurons of the nigrostriatal pathway that degenerate in Parkinson's disease (PD). In animal models of PD, GDNF delivery has been shown to both protect dopaminergic neurons against toxin-induced injury and to rescue damaged neurons, promoting recovery of the motor deficit. GDNF may act both as a target-derived neurotrophic factor in the striatum, and as a local neurotrophic factor at the level of neuronal cell bodies in the substantia nigra. The neuroprotective and regenerative effects of GDNF are mediated by increases in the activity of antioxidant enzymes and induction of antiapoptotic proteins and cell adhesion molecules. [ABSTRACT FROM AUTHOR]

Published
2007
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105. Stuck! Stalling in Computer Games

Author

Cardoso, Pedro, Carvalhais, Miguel, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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106. Antecedents of Loyalty in Online Retail Stores in Customer Service

Author

do Espírito Santo, Pedro Manuel, Cardoso, Patrícia Azinheira, Marques, Alzira Maria Ascensão, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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110. Flexible Visual Identity Systems in Cultural Institutions

Author

Figueira, Maria, Raposo, Daniel, Brandão, João, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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112. Fondazione Italiana Tipoteca and Museo Bodoniano: The Spill-Over of Digitisation of Typographic Collections into the Museum’s Digital and Physical Realm

Author

Bonini Lessing, Emanuela F., Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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113. Alcântaras, o som é um sistema: Touch the Sound/Reach the Sound

Author

Brasil, Ramusyo, Alves, Cesário, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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116. Exploring the Factors Affecting the Wayfinding Experience of Elderly Users in General Hospitals: A Multi-Criteria Decision-Making Perspective

Author

Fan, Jieqiong, Choi, Albert Young, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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118. Macau Cultural Tapestry: Unravelling a City’s Visual Identity Through Its Patterns and Textures— Digital Archive and Mapping

Author

de Abreu, Filipa Martins, Seck, Mamadú, Pinheiro, Francisco Vizeu, Estadieu, Gérald, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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120. Beyond the Gaze: Decoding Behavioral Dynamics in Sans Serif Fonts Through Eye-Tracking Exploration

Author

Teixeira, Ana Rita, Brito-Costa, Sónia, de Almeida, Hugo, Espada, Sílvia, Antunes, Fernanda, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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121. Children and Youth Participation in Digital Environment: A Systematic Literature Review

Author

Costa, Conceição, Pereira, Sara, Brandão, Daniel, Pinto, Diana, Jardim, Carolina, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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122. Developing a Smart Pill Dispenser to Support Aging Individuals

Author

Viana, Óscar T., Lima, Octávio, Terroso, Miguel, Vilaça, João L., Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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123. Seeding a Sustainable Mindset to Reduce Energy Consumption and Carbon Footprint Through Sustainable Digital Design Principles

Author

Rafael, Sónia, Mirmotahari, Seyed Mohsen, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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124. Digital Environment to Support Well-Being, Empowerment and Experience of Care

Author

Losciale, Piera, Scarcelli, Alessandra, Di Roma, Annalisa, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Brandão, Daniel, editor, Martins, Nuno, editor, and Duarte, Emilia, editor

Published
2025
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128. Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells.

Author

Rosmaninho-Salgado, Joana, Araújo, Inês M., Álvaro, Ana Rita, Duarte, Emília P., and Cavadas, Cláudia

Subjects
CATECHOLAMINES, CHROMAFFIN cells, NEUROPEPTIDE Y, PROTEIN kinases, NITRIC oxide, GUANYLATE cyclase
Abstract

The adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release from mouse chromaffin cells. The stimulatory effect of NPY mediated by NPY Y1 receptor activation was lost in the absence of extracellular Ca2+. On the other hand, inhibition of nitric oxide synthase and guanylyl cyclase also decreased the stimulatory effect of NPY. Moreover, catecholamine release stimulated by NPY or by the nitric oxide donor (NOC-18) was inhibited by mitogen-activated protein kinase (MAPK) and protein kinase C inhibitors. In summary, in mouse chromaffin cells, NPY evokes catecholamine release by the activation the NPY Y1 receptor, in a Ca2+-dependent manner, by activating mitogen-activated protein kinase and promoting nitric oxide production, which in turn regulates protein kinase C and guanylyl cyclase activation. [ABSTRACT FROM AUTHOR]

Published
2007
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130. Two types of ω-agatoxin IVA-sensitive Ca2+ channels are coupled to adrenaline and noradrenaline release in bovine adrenal chromaffin cells.

Author

Baltazar, Graça, Ladeira, Idalina, Carvalho, Arsélio P., and Duarte, Emília P.

Abstract

To clarify the role of P-type Ca2+ channels in catecholamine release from adrenal chromaffin cells we examined the concentration dependence of the effect of ω-agatoxin IVA on the release both of adrenaline and noradrenaline induced by a K+-evoked depolarization. ω-Agatoxin IVA caused a biphasic dose-dependent inhibition of secretion with a high-potency component (IC50<1 nM), responsible for 10–15% of catecholamine release evoked by 70 mM K+, and a low-potency component that accounted for about 40% of release, with IC50 values of 57 nM and 48 nM for noradrenaline and adrenaline release, respectively. The release of catecholamines from chromaffin cells was also inhibited dose dependently by ω-conotoxin MVIIC with IC50 values of 182 and 218 nM for noradrenaline and adrenaline release, respectively. The effects of 3 nM ω-agatoxin IVA and 3 μM ω-conotoxin MVIIC were additive, indicating that at the concentrations used the toxins were acting at independent sites, presumably, P- and Q-type Ca2+ channels. The blockade of Q-type channels inhibited the release of adrenaline (72 ± 4.1%) significantly more than the release of noradrenaline (50 ± 2.7%), suggesting a higher density or a closer coupling of these channels to exocytosis in adrenergic chromaffin cells. The blockade of P-type channels caused a greater inhibition of catecholamine secretion at low levels of K+-evoked depolarization and shorter times of stimulation than that observed at higher levels of stimulation. The contribution of Q-type channels to catecholamine secretion did not change significantly with the intensity of stimulation. The data show that two types of ω-agatoxin IVA-sensitive Ca2+ channels are coupled to catecholamine release in chromaffin cells, and that the contribution of P-type channels to secretion is larger at low levels of depolarization. [ABSTRACT FROM AUTHOR]

Published
1997
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131. Critical Transition: Merging Approaches Toward Sustainability

Author

Jakobsone, Liene, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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133. Echinodesign: Case Study for Bio-Inspired Projects

Author

Soares, Theska, Vicente, Marcelo, Perricone, Valentina, Arruda, Amilton, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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135. Interactions to Be: The Case of Speculative Interactive Print Media

Author

Neves, Marco, Silva, Sofia, Bozzi, Carolina, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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138. Bio-Sustainable Materials for Tailor-Made Well-Being: A Case Study of Behavioral Packaging for Cosmetics Self-Production

Author

Ricci, Marina, Di Roma, Annalisa, Scarcelli, Alessandra, Fiorentino, Michele, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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141. Kinetic Calendar for Emotional vs Physical Stress Tracking in Women

Author

Dominguez, Mariel, Giambattista, Angela, Di Lucchio, Loredana, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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144. S&S’21 Marine Plastic Pollution, Design & Circular Economy

Author

Farinha, Isabel, Duarte, Carlos A. M., de Carvalho, Mafalda Gil, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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146. Material Inter-actions vs Sense Trans-action. Grit Surfaces

Author

Pagliarulo, Rosa, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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147. PhD Research for 'Trans-action': The Role of Research Questions

Author

Clemente, Violeta, Tschimmel, Katja, Pombo, Fátima, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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148. A Design-Based Approach to Support Hospital Wards in the Digital Turn. The Development of a Case Study to Support Hospital Ward in Reducing Errors in Therapy; a Problem of Intergenerational and Cultural Gaps

Author

Penati, Antonella Valeria, Standoli, Carlo Emilio, Pellecchia, Gaia Maria, Lavizzari, Francesca, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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149. Smart Outdoors for Elderly: Insights from Expert Interviews

Author

Satte, Felipe, Ayanoglu, Hande, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Duarte, Emilia, editor, and Di Roma, Annalisa, editor

Published
2023
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