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584 results on '"Drouet C"'

101. Les facteurs modifiant la sévérité des angio-œdèmes bradykiniques (AOBK) héréditaires diffèrent selon le type d’angio-œdème

Author

Charignon, D., primary, Ghannam, A., additional, Defendi, F., additional, Ponard, D., additional, Monnier, N., additional, Lopez-Trascasa, M., additional, Launay, D., additional, Caballero, T., additional, Djenouhat, K., additional, Fain, O., additional, Cichon, S., additional, Martin, L., additional, and Drouet, C., additional

Published
2014
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104. THU0154 Biomarker Sets PREDICT Therapeutic Response to Tnf-Inhibitors in Rheumatoid Arthritis and Spondyloarthritis Patients: A Theragnostic Approach in A Multicenter Cohort: Table 1.

Author

Baillet, A., primary, Trocmé, C., additional, Marotte, H., additional, Soubrier, M., additional, Tébib, J., additional, Thomas, T., additional, Miossec, P., additional, Pellot-Prades, B., additional, Grange, L., additional, Toussaint, B., additional, Juvin, R., additional, Morel, F., additional, Drouet, C., additional, and Gaudin, P., additional

Published
2014
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105. Chronic restraint stress induces severe disruption of the T-cell specific response to tetanus toxin vaccine

Author

Tournier, J- N, Mathieu, J, Mailfert, Y, Multon, E, Drouet, C, Jouan, A, and Drouet, E

Subjects
Male, Mice, Inbred BALB C, Original Articles, Lymphocyte Activation, Lymphocyte Subsets, Mice, Immunoglobulin M, Tetanus Toxin, Stress, Physiological, T-Lymphocyte Subsets, Immunoglobulin G, Chronic Disease, Concanavalin A, Animals, Cytokines, Corticosterone, Cell Division, Spleen
Abstract

Chronic stress is known to induce immunological disorders. In the present study we examined the consequences of chronic restraint stress on the immune response to tetanus toxin in mice. We investigated the repartition of subsets of lymphoid cells in blood and spleen, the functional ability of lymphocytes to proliferate and to produce cytokines, and antibody titres against tetanus toxin following stress. We report discordance of the stimulation index of lymphocytes in the restraint group: the proliferating rate severely decreased following stimulation with a relevant antigen, whereas it increased with mitogen. Thus, we report a decrease in cytokine production with relevant antigen (interferon-gamma and interleukin-10), without a T helper type 1 and 2 secretion imbalance. Moreover, we observed an alteration in the humoral response, including a delay in isotype maturation and an immunoglobulin G1/G2a imbalance.

Published
2001

107. Co-operation between human CR1 (CD35) and CR2 (CD21) in internalization of their C3b and iC3b ligands by murine-transfected fibroblasts

Author

Grattone, M L, Villiers, C L, Villiers, M-B, Drouet, C, and Marche, P N

Subjects
B-Lymphocytes, Antibodies, Monoclonal, chemical and pharmacologic phenomena, Original Articles, Fibroblasts, Transfection, Mice, Complement C3b, Receptors, Complement 3b, Animals, Humans, Receptors, Complement 3d, Dimerization, Cells, Cultured, Protein Binding
Abstract

CR1 and CR2 are expressed as associated proteins on the B-lymphocyte surface. To investigate their respective contributions to the internalization of C3 fragments, transfected murine fibroblasts expressing human CR1, CR2, or both CR1 and CR2 were produced. CR1- and CR1-CR2-expressing cells bound C3b and C3b-dimer whereas CR2- and CR1-CR2-expressing cells bound iC3b and C3de. In all cases, maximum binding was achieved at low ionic strength. CR1-CR2-positive cells internalized two- to threefold more C3b and 1.5-fold more iC3b than CR1- and CR2-single-positive cells, respectively. Internalization of the anti-CR1 antibody J3D3, or C3de was at the same level, in both double-transfected and single-transfected cells. Furthermore, the internalization of C3b dimer by CR1-CR2 cells was impaired in the presence of OKB7, an anti-CR2-blocking antibody, but it was not altered in CR1 cells. Taken together, these findings suggest that CR1 and CR2 collaborate to internalize C3b and iC3b proteins. We suggest that the induction of conformational changes of the ligands enhances their binding to both receptors.

Published
1999

109. Approche mécanistique de l'oxydation du CO sur manganites spinelles lacunaires par l'observation d'une correlation entre le taux de nonstoechiométrie et l'activité catalytique

Author

Laberty, C., Drouet, C., Alphonse, P., Rousset, J.L., Mirodatos, C., IRCELYON, ProductionsScientifiques, Institut de recherches sur la catalyse (IRC), and Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.CATA] Chemical Sciences/Catalysis, [CHIM.CATA]Chemical Sciences/Catalysis
Published
1998

113. Evidence for intracellular complement activation vital to Th1 immunity

Author

Liszewski, M.K., primary, Kolev, M., additional, Le Friec, G., additional, Leung, M., additional, Bertram, P.M., additional, Pickering, M.C., additional, Drouet, C., additional, Meri, S., additional, Arstila, T.P., additional, Pekkarinen, P.T., additional, Reinheckel, T., additional, Cordoba, S. Rodriguez de, additional, Afzali, B., additional, Atkinson, J.P., additional, and Kemper, C., additional

Published
2013
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