101. NEWER CARDIOTONIC AGENTS – BENEFICIAL EFFECTS ON NEWBORN MYOCARDIUM
- Author
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Timothy L Degner, Thomas S. Klitzner, Ross R Ravin, and William F. Friedman
- Subjects
Inotrope ,medicine.medical_specialty ,Chemistry ,Dose dependence ,Cardiotonic Agents ,Amrinone ,Contractility ,Endocrinology ,Age groups ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Beneficial effects ,Dose response data ,medicine.drug - Abstract
Previous data has suggested a deleterious action of Amrinone (Am) on newborn (NB) myocardium. An investigation of the relationship between dose, age, and contractility has been undertaken using isolated right ventricular papillary muscles from NB (0-5 days), juvenile (J) (18-29 days), and adult (A) New Zealand white rabbits. At least six rabbits were studied in each age group using four sequential concentrations of Am (30, 100, 200, 500 mcg/ml). Peak tension (PT), maximum rate of tension development (+dP/dt) and maximum rate of relaxation (-dP/dT) were measured after a fifteen minute equilibration period at each concentration. Repeated measures analysis was used to compare dose response data between age groups. T-tests were used to compare normalized data from the various age groups at a given concentration. Adult heart demonstrated an increase in PT, +dP/dt and -dP/dT with each increase in Am concentration. NB and J heart demonstrated a significant (P
- Published
- 1987
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