101. Neuropsychological function at first episode in treatment-resistant psychosis: findings from the ÆSOP-10 study
- Author
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Peter B. Jones, Abraham Reichenberg, Kevin Morgan, Julia Lappin, Izabela Pilecka, Anil Safak Kacar, Craig Morgan, Robin M. Murray, Arsime Demjaha, Paola Dazzan, Paul Fearon, Gillian A. Doody, Catherine Wise, James H. MacCabe, Kim Donoghue, Jolanta Zanelli, Eugenia Kravariti, Fowzia Ibrahim, Kaçar, Anıl Şafak, Kravariti, Eugenia, Demjaha, Arsime, Zanelli, Jolanta, Ibrahim, Fowzia, Wise, Catherine, MacCabe, James H., Reichenberg, Abraham, Pilecka, Izabela, Morgan, Kevin, Fearon, Paul, Morgan, Craig, Doody, Gillian A., Donoghue, Kim, Jones, Peter B., Dazzan, Paola, Lappin, Julia, Murray, Robin M., Graduate School of Health Sciences, and Department of Neuroscience
- Subjects
Adult ,Male ,Psychosis ,Adolescent ,Population ,Intelligence ,Cohort study ,Frst episode ,Neuropsychological ,Population-based ,Schizophrenia ,Treatment resistant ,Drug Resistance ,Psychology ,Psychiatry ,Context (language use) ,Neuropsychological Tests ,03 medical and health sciences ,Executive Function ,Young Adult ,0302 clinical medicine ,treatment resistant ,Medicine ,Humans ,psychosis ,education ,first episode ,Applied Psychology ,Spatial Memory ,First episode ,education.field_of_study ,business.industry ,Neuropsychology ,Original Articles ,Middle Aged ,Verbal reasoning ,medicine.disease ,neuropsychological ,United Kingdom ,030227 psychiatry ,3. Good health ,population-based ,schizophrenia ,Psychiatry and Mental health ,Cross-Sectional Studies ,Psychotic Disorders ,Linear Models ,Female ,Verbal memory ,business ,030217 neurology & neurosurgery ,Clinical psychology ,Follow-Up Studies - Abstract
Background: neuropsychological investigations can help untangle the aetiological and phenomenological heterogeneity of schizophrenia but have scarcely been employed in the context of treatment-resistant (TR) schizophrenia. No population-based study has examined neuropsychological function in the first-episode of TR psychosis. Methods: we report baseline neuropsychological findings from a longitudinal, population-based study of first-episode psychosis, which followed up cases from index admission to 10 years. At the 10-year follow up patients were classified as treatment responsive or TR after reconstructing their entire case histories. Of 145 cases with neuropsychological data at baseline, 113 were classified as treatment responsive, and 32 as TR at the 10-year follow-up. Results: compared with 257 community controls, both case groups showed baseline deficits in three composite neuropsychological scores, derived from principal component analysis: verbal intelligence and fluency, visuospatial ability and executive function, and verbal memory and learning (p valuesâ 0.001). Compared with treatment responders, TR cases showed deficits in verbal intelligence and fluency, both in the extended psychosis sample (t =-2.32; p = 0.022) and in the schizophrenia diagnostic subgroup (t =-2.49; p = 0.017). Similar relative deficits in the TR cases emerged in sub-/sensitivity analyses excluding patients with delayed-onset treatment resistance (p values, Medical Research Council UK (MRC); National Institute for Health Research (NIHR); Wellcome Trust; European Union (European Union); Horizon 2020; European Community's Seventh Framework Program; Stanley Medical Research Institute
- Published
- 2018