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Cardiac glycosides show anticancer activities and their deoxy-sugar chains are vital for their anticancer effects. In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and get more potent anticancer agents, a series of MeON-neoglycosides of digoxigenin was synthesized and evaluated. First, ten 6-deoxy- and 2,6-dideoxy-d-glucopyranosyl donors were synthesized starting from methyl α-d-glucopyranoside and 2-deoxy-d-glucose. Meanwhile, the digoxigenin was obtained by acidic hydrolysis of commercially available digoxin as glycosyl acceptor. Then, a 22-member MeON-neoglycoside library of digoxigenin was successfully synthesized by neoglycosylation method. Finally, the induction of Nur77 expression and its translocation from the nucleus to cytoplasm together with cytotoxicity of these MeON-neoglycosides were evaluated. The SAR analysis revealed that C3 glycosylation is required for their induction of Nur77 expression. Moreover, some MeON-neoglycosides (2b and 8b) could significant induce the expression of Nur77 and its translocation from the nucleus to cytoplasm. However, these compounds showed no inhibitory effects on the proliferation of cancer cells, suggesting that they may not induce apoptosis of NIH-H460 cancer cells and their underlying potential and application toward cancer cells deserves future study.

An improved design of a dual-band circularly polarized (CP) square loop antenna under even-mode resonance is presented in this paper. The designed antenna is fed by a pair of orthogonal dipole launcher with fork-like stubs and connected with a simple balun above the ground plane. Four L-shaped tuning stubs can simultaneously excite the first two, odd-order even-modes. An approximate dual-band ratio design formula is also deduced by using data fitting technique. The proposed antenna exhibits identical CP sensing at its two resonant modes. The proposed approach is expected to get applications in dual-band circularly polarized antenna designs.

Lightning strike and electromagnetic induction resulted from lightning pose a serious threat to the electronic equipment and weapons on the naval ship. Systematic protection design is therefore essential to reduce the probability of electrical equipment and weapons being damaged. In this paper, we discussed the whole ship direct-lightning protection scheme, combining the installation of lightning rods on top of masts as well as the direct lightning strike protection and reinforcement of the local high structures such as ship borne medium-wave and short-wave communication antennas and large radar antennas. The design plans that developing lightning induction protection from different levels such as the platform, system, equipment or subsystem are analysed. The contents and methods of relevant verification and assessment test are also discussed.

A CuO-Al2O3 composite coating was obtained by an AC deposition and a followed secondary MAO treatment in an acidic copper sulfate electrolyte and an alkaline sodium hexametaphosphate electrolyte. Analyzes on phase and elemental composition and microstructure showed that a continuous CuO layer was formed on the top of the original MAO coating. EIS test suggested that after a secondary MAO treatment for 1 min, the samples obtained by AC deposition for 5 min had the best corrosion resistance, because of the barrier of CuO layer to the NaCl solution.

Diabetic nephropathy (DN) exhibits a deteriorating course that may lead to end-stage renal failure. Astragalosides have been clinically tested for the treatment of DN, but the mechanism is unclear at present. In this study, the effects of astragalosides were investigated on high glucose-induced proliferation and expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), type IV collagen (colIV) and fibronectin (FN) in glomerular mesangial cells (MCs). Cell proliferation was determined by 5-bromo-2'-deoxyuridine assay, and the expression of TGF-β1, CTGF, colIV and FN mRNA and proteins in MCs was detected by reverse transcription-polymerase chain reaction and ELISA assay, respectively. The results showed that high glucose clearly induced the proliferation of MCs and increased the expression of TGF-β1, CTGF, colIV and FN. Treatment with 50, 100, 200 µg/ml astragalosides inhibited cell proliferation and the expression of TGF-β1, CTGF, colIV and FN induced by high glucose. Thus, it is concluded that astragalosides inhibit the increased cell proliferation and expression of major extracellular matrix proteins that are induced by high glucose, indicating their value for the prophylaxis and therapy of DN.

Micro-arc oxidation (MAO) coatings were prepared on Al substrate in alkaline sodium hexametaphosphate, sodium silicate and sodium aluminate electrolytes, the breakdown voltage and responsive current respectively decreased and increased with increasing the electrolyte concentration. The behavior of electrolyte during MAO processes was analyzed and discussed based on the data of the coating microstructure, elemental and phase composition, and the carrier density and impedance of the coating. The behavior can be explained by a mechanism in which anions incorporated into the coating reduced the anion vacancies, thus reducing the carrier density and improving the impedance.

For solving the applicability of size proportion ofcut tobacco under the Internet environment, The device adjusting size proportion of cut tobacco needs to be developed including a feeding belt conveyor, a tobacco regulating device, a discharging belt conveyor, a guiding groove and a fixed bracket. Among these devices the feeding belt conveyor adopts two-way control of size proportion ofcut tobacco without adjusting the choice; the device adjusting size proportion of cut tobacco consists of a feed roller of tobacco, a Uniform roller of tobacco and a Cut tobacco roller, mainly by adjusting the feeding roller of tobacco, Cut tobacco roller speed difference and gap adjustment to control size proportion cut tobacco. Application test was made in Henan tobacco corporation. The results showed that: the gap between the feeding roller and the broken roller are the significant factors in proportion of long stands rate, middle stands rate, short stands rate and small particles rate. the long stands rate is positively associated with the gap, the rest are negatively correlated with the gap, ② the rotational speed of cut tobacco smoothing roller, cut tobacco feeding roller, Cut tobacco cutting roller has certain effect on, proportion of long stands rate, middle stands rate, short stands rate and small particles rate and cannot be ignored in practical work. Conclusion: This design can improve the structure of the cut tobacco through the gap between the cut tobacco feed roller and the cut tobacco break roller. How to quantify the specific effect requires special research.

Numerous methods that generate time-varying speckle patterns have been used unsuccessfully to eliminate speckle. In this study, the speckle influence degree (SID) method is used in conjunction with a measurement system that emulates the human eyes. Time-varying speckle patterns are generated at different velocities, whereby the correlation degree between the speckle patterns, the correlation time, and SID, are calculated as a function of velocity. It is shown that the correlation time is 6 ms and SID is reduced to 6.4% when the velocity is increased up to 40 μ m ∕ ms . Further, when a chip motor with a velocity of 286 μ m ∕ ms is used to modulate speckle patterns, the correlation time and SID are reduced to 1 ms and 3.2%, respectively. Based on these results, the mechanism of time-varying speckle patterns is quantified for the first time, laying a scientific basis for proposing innovative methods of speckle elimination.

Poria cocos, an important medicinal and edible fungus, is well known in East Asia. The main active components are water-soluble polysaccharides (WPS) and triterpenoids. Due to the growing market demand, long cultivation period, and consumption of pine trunk during cultivation, alternative methods for producing P. cocos or its active components should be investigated. In this study, WPS, triterpenoids, monosaccharide composition, and essential oil in fermented mycelia and cultivated sclerotium were analyzed using UV spectrophotometry, HPLC, pre-column derivatization, and HS-GC/MS, respectively. Our results showed that the WPS and triterpenoids in mycelia are several times higher than those in sclerotium. Among the 62 compounds identified by HS-GC/MS analysis from the essential oil obtained from the fermentation media and a fresh external layer, the two main fragrances in common were linalool and methyl phenylacetate. Our results suggested that it is applicable to produce polysaccharides and triterpenoids by the fermentation of P. cocos, and a strategy to improve triterpenoid production in the fermentation process was proposed.

The interest conflict is an important factor affecting the supply chain (SC) performance, so it is very important to set up a reasonable coordination mechanism to eliminate the SC conflicts. Considering the fact that suppliers' effort performance level and fairness concern behavior are important factors affecting SC performance, we can develop SC models to analyze and compare SC decisions under the centralized decision and decentralized decision, and then we design a SC coordination mechanism through cost sharing. The results show that the designed coordination mechanism can effectively solve the conflict problem of SC, mobilize SC members’ motivation and initiative without damaging their profits, and realize the long-term cooperation between the retailer and multi-suppliers. It also can achieve the Pareto improvement and the sustainable development of SC.

Speckle contrast (SC) is universally used to evaluate speckle in laser display, which has virtues of briefness in calculating and definitude in physical meaning. But the results characterized by SC is usually inconsistent with human visual perception. In this study, an alternative framework for speckle evaluation, speckle influence degree (SID), is developed. It considers the effects of SC, sampling rate, and image resolution on perceived speckle by human eyes. Theoretical analysis is firstly conducted. Then, speckle images of different sampling rate, SC, and image resolution are generated and calculated. Finally, SID is shown to be a more comprehensive metric that could characterize the influence of sampling rate and image resolution and that is better matched with subjective perception of human eyes than SC.

Ceramic coatings were performed on aluminum through plasma electrolytic oxidation (PEO) in a Na5P3O10 solution with various concentrations of NaOH. It was revealed that the concentration of NaOH affected the types of anodic films and the activity of plasma discharges. Emphatic investigation was performed on the coatings fabricated in the electrolyte with addition of 1 g L−1 NaOH, focusing on the coating microstructure evolution and coating corrosion resistance. Some coatings were detached from the substrate, showing that the oxide particles on the anodic film C/S interface underwent profile variations from hemisphere to polygon, and its interpore distance decreased over time. The formations of pores of anodic films and plasma discharge of the PEO coatings were both easy to occur around the existing pores and the existing discharge channels. Fractured cross-section showed that a pancake-like structure corresponded to a discharge channel, a cavity, and a barrier layer protrusion whose area was similar to that of the corresponding pancake-like structure. The data of potentiodynamic polarization measurements showed that the sample treated with PEO for 10 min possessed the lowest icorr value of 4.97E-8 A cm−2, the most positive Epit value of −0.63 V, and the highest Rp value of 2.66E5 Ω cm2. EIS data of 10 min sample exhibited the highest R2 value of 1.61E6 Ω cm2, demonstrating the best corrosion resistance among these samples.

What is known and objectives Tacrolimus is widely used for kidney transplantation in children. However, the narrow therapeutic window and considerable interindividual and intraindividual variabilities make tacrolimus untoward to design an optimum dosage for paediatric personalized medicine. Our research aims to establish the tacrolimus population pharmacokinetics (PPK) of Chinese paediatric kidney transplantation patients and to distinguish covariates impacting variabilities. Methods Chinese paediatric kidney transplantation patients treated with tacrolimus between January 2014 and April 2018 from Children's Hospital of Fudan University were retrospectively analysed. A total of 51 Chinese paediatric kidney transplantation patients were analysed using non-linear mixed effects modelling (NONMEM). The effects of population characteristics, biological features and drug combination were assessed. The final PPK model was evaluated using visual inspection of routine diagnostic plots and the internal validation method of bootstrap. Results Our data met the condition of a one-compartment model, and the final model was CL/F = 32.7 × (WT/70)0.75 × (1 - WZ × 0.341) × (HGB/97)-0.508 ; V/F = 1890 × (WT/70) × (POD/57)0.816 , where WT, WZ, HGB and POD were weight, Wuzhi capsule (extracted from schisandra sphenanthera, whose primary efficient constituents are schisantherin A, schisandrol B, schisandrin etc, and often used to treat drug-induced hepatitis in Chinese organ transplant patients), haemoglobin and post-transplant day, respectively. What is new and conclusion The tacrolimus PPK model in Chinese paediatric kidney transplantation patients was developed, and Wuzhi capsule and haemoglobin influence tacrolimus elimination in paediatric kidney transplantation patients.

Supplemental Digital Content is available in the text, Ductal carcinoma in situ (DCIS) represents a heterogeneous disease in its histologic appearance and biological potential. Some women treated for DCIS subsequently develop invasive breast cancer. DCIS with microinvasion is considered as the interim stage in the progression from DCIS to invasive breast cancer. Analysis of the differences between DCIS and DCIS with microinvasion may aid in understanding the characteristic of DCIS with microinvasion and identifying biological factors determining progression of DCIS to invasive disease. Retrospective analysis of 219 cases between 2012 and 2018 was performed in our institution. The pathological results and axillary lymph nodes status were collected. Analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in pure DCIS (164 cases), and DCIS with microinvasion (55 cases) using immunohistochemistry. DCIS with microinvasion had a higher nuclear grade (P

To investigate the clinical application of clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for sepsis, in order to promote the follow-up revision and further promotion of the Guidelines. Copies of 500 application evaluation questionnaire and 500 copies of applicability evaluation questionnaire were given to the clinicians who had used this Guideline in China, both in a form of registered questionnaire, and a database was established by Excel 2016 for descriptive statistical analysis. Copies of 211 application evaluation questionnaire and 211 copies of applicability evaluation questionnaire were collected. We can conclude from the survey that we should adjust the whole content and structure on the basis of better evaluation of the present recommendation scheme, update the prescription selection and clinical evidence of the recommendation scheme, and put forward the improvement measures for the hindrance factors in the application of the Guideline. Furthermore, in order to promote the Guideline more clearly, we should strengthen the doctor-patient education, improve guidance quality and increase the publicity, providing basis for the implementation and promotion strategies of the Guideline.

A novel multi-beam antenna based on Butler matrix is designed and realized. In this paper, Butler matrix adopts the substrate integrated waveguide and double layer technology to realize the miniaturization of the network, and the two-layer directional coupler achieves good matching and better flatness in amplitude and phase by using multiple slots, besides, the edge gradient short holes of short slot coupler is adopted to better ensure the equipartition of energy, and inhibit the emergence of TE30. The proposed multi-beam antenna has operation frequency range of 8.0 to 8.5GHz with perfect port matching performance. The maximum gain of the intermediate beam of the antenna reaches 11.2dBi, and the maximum gain of the beam on both sides reaches 10.0dBi with ± 38 ° beam point.

Objective: The aim of this study was to assess the effectiveness and safety of transdermal fentanyl for the treatment of moderate or severe cancer-related pain. Materials and Methods: Electronic databases including PubMed, Embase, the Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, and Chongqing Weipu and Wanfang Database were searched for relevant studies published prior to January 2015. Only randomized controlled trials on the use of the transdermal fentanyl patch for the treatment of cancer pain were selected. Two reviewers independently screened the studies and extracted data. The quality assessment of the studies included was based on the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). RevMan 5 (version 5.3) and Trial Sequential Analysis software (TSA, version 2.1, provided by Copenhagen Trial Unit, Denmark) were used for data analyses. Results: A total of 35 studies involving 3406 participants met the inclusion criteria for this meta-analysis. There was no statistically significant difference with regard to the effectiveness of management for cancer pain between the use of transdermal fentanyl patch and oral morphine (risk ratio = 1.00, 95% confidence interval, 0.97–1.03, P > 0.05). TSA results demonstrated that the cumulative Z-score crossed its monitoring boundaries, and therefore, reliable conclusions had been drawn. Moreover compared with oral morphine, the use of transdermal fentanyl patch resulted in statistically significantly decreased incidence of constipation, nausea and vomiting, drowsiness, and urinary retention. There was a significantly greater incidence of skin irritation in patients who used a transdermal fentanyl patch (P < 0.05). Conclusions: The findings from this study demonstrate that use of transdermal fentanyl for the management of moderate or severe cancer pain had more advantages compared to oral morphine.

The factors that influence environmentally-friendly powder rubber powdering are introduced. Types and dosage of isolation agent, types and dosage of coagulant, environmental antioxidant, condensation temperature, stirring speed on the effect of powder rubber are examined. Thus a simple method to prepare environmental powder rubber is provided.As a physical variation of traditional bulk rubber, powder rubber can change the situations that high energy consumption and high labor intensity of the former. And it also can make the mixing process become continuous, automated, energy-saving and so on. In recent years, with the progress of rubber processing industry, the demand of powder rubber increases rapidly. And there is a intense requirement of supplying environmentally-friendly powder rubber[1-3]. So it is very important to do this experiment.

The mechanism of cable crosstalk involving what and how does the factors affect the level of crosstalk is introduced in detail. A transmission line model for predicting crosstalk between power cable and the other wires nearby with common reference ground based on multiconductor transmission theory (MTL) is developed. Crosstalk among circuit configurations when the victim cables with load terminations are different types is analyzed and simulated. Models where the types of the victim lines are shielded coaxial cable, shielded twisted pair and unshielded twisted pair are simulated. It is found that the shielding can provide an attenuation of about 50dB than the unshielded cables. In addition, the condition of multi-cable coupling is simulated and some thoughts are brought out to inspire more detailed study. Finally, some measures are suggested to suppress the crosstalk between cables according to the two-type of coupling mechanism (inductive coupling and capacitive coupling).

We present long-term optical multi-band photometric monitoring of the blazar OJ 287 from 6 March 2010 to 3 April 2016, with high temporal resolution in the V R I -bands. The flux variations and colour-magnitude variations on long and short timescales were investigated to understand the emission mechanisms. In our observation, the major outbursts occurred in January 2016, as predicted by the binary pair of black holes model for OJ 287, with F v a r of 1.3∼2.1%, and variability amplitude (Amp) of 5.8∼9.0%. The intra-night variability (IDV) durations were from 18.5 to 51.3 min, and the minimal variability timescale was about 4.7 min. The colour-magnitude variation showed a weak positive correlation on the long timescale with Pearson’s r = 0 . 450 , while a negative correlation was found on intra-night timescales. We briefly discuss the possible physical mechanisms that are most likely to be responsible for the observed flux and colour-magnitude correlation variability.

A dual-frequency, circularly polarized (CP) square loop antenna under even-mode resonance is presented. The square loop antenna is diagonally fed by a fork-like dipole launcher. Four tuning stubs are symmetrically introduced near the current distribution nulls of the second odd-order resonant even-mode. In this way, the second odd-order even-mode is excited and dual-band circularly polarized characteristic can be realized. The dual-band behavior of the antenna is numerically studied and a closed-form formula is deduced. The preliminary result in this work is expected to be useful in future dual-band CP loop antenna designs.

Diabetic nephropathy (DN) is one of the most important causes that leads to end-stage renal disease and the efficacy of strategies currently available for the prevention of DN remains unsatisfactory. Sitagliptin (SIT), which is a dipeptidyl peptidase-4 inhibitor, exhibited a modest beneficial effect on glycated hemoglobin levels and is capable of ameliorating renal ischemia reperfusion injury. By determining the expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), collagen type IV (ColIV) and fibronectin (FN) levels in high glucose-cultured glomerular mesangial cells (MCs), the present study aimed to assess the anti-proliferative and anti-fibrotic effects of SIT on the therapeutic potential for the prevention of DN and its mechanism. Specifically, cell proliferation was determined via cell counting kit-8 assay, and the expression levels of TGF-β1 and CTGF mRNA were detected by reverse transcription polymerase chain reaction analysis. Furthermore, the secretion of TGF-β1, CTGF, ColIV and FN proteins was measured via enzyme-linked immunosorbent assays. The results demonstrated that high glucose induced the proliferation of MCs and enhanced the expression of TGF-β1, CTGF, ColIV and FN. Furthermore, treatment with SIT inhibited cell proliferation and the expression of TGF-β1, CTGF, ColIV and FN induced by high glucose. In conclusion, SIT inhibits cell proliferation and the expression of the major extracellular matrix proteins induced by high glucose, indicating its value for treating or relieving DN.

Midazolam is a sedative used by patients with mechanical ventilation. However, the potential clinical value is not fully explored. In this report, we made use of a neuroblastoma-spinal cord hybrid motor neuron-like cell line NSC34, and elucidated the potential role of Midazolam on these cells under the insult of oxidative stress. We found the protective effect of Midazolam on motor neurons against cytotoxicity induced by the combination of oligomycin A and rotenone (O/R) or phenylarsine oxide. The characteristics of apoptosis, such as the ratio of TUNEL+ cells or the expression level of cleaved Caspase-3, was decreased by 22 or 45% in the presence of Midazolam. Furthermore, this effect was correlated with the JNK-ERK signaling pathway. Either phosphorylation of ERK or JNK was positively or negatively modulated with the treatment of Midazolam in NSC34 cells attacked by reactive oxygen species. Meanwhile, inhibition or activation of the JNK-ERK pathway regulated the protective effect of Midazolam on NSC34 cells with oxidative stress insult. Collectively, this study elucidated a previously unidentified clinical effect of Midazolam, and put forward the great promise that Midazolam may be considered as a potential candidate to the treatment of motor neuron disease.

rs5219 is in Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene, located at 11p15.1. Researches on the association between rs5219 gene polymorphism with type 2 diabetes mellitus (T2DM) were performed extensively, but the results remain controversial. To investigate the relationship, a meta-analysis involving 21,464 individuals was conducted.Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of this association. Publication bias was evaluated with Begg's test. Our research includes three gene models: allelic genetic model (K-allele vs. E-allele), recessive genetic model (KK vs. EK+EE) and dominant genetic model (EE vs. EK+KK).In allelic genetic model, subgroup analysis demonstrated rs5219 K-allele was relevant to T2DM risk in Caucasian (OR: 1.16, 95% CI: 1.09-1.24, P=0.000) and East Asian (OR: 1.19, 95% CI: 1.13-1.26, P=0.000), recessive genetic model indicated rs5219 KK genotype was related to T2DM risk in Caucasian, East Asian, South Asian, and North African (OR: 1.27, 95% CI: 1.17-1.38, P=0.000), dominant genetic model pointed out rs5219 EE genotype was an opposite association with T2DM risk in Caucasian (OR: 0.86, 95% CI: 0.78-0.94, P=0.001). No obvious evidence of publication bias was found.There was a believable evidence to verify that rs5219 variation was associated with T2DM.

Oxidative stress has a central role in the progression of diabetes mellitus (DM), which can directly result in the injury of islet β cells and consequent hyperglycemia. The aim of the present study was to evaluate the possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice. Oxidative stress was assessed by the levels of total antioxidative capability and glutathione in the serum. Fasting blood glucose and insulin levels, as well as the pancreas weight index and the histological changes in the pancreas, were also determined. The results showed that, after fours weeks of treatment with PPE, BBPE or PPE + BBPE, DM mice showed, to different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity. These changes were particularly evident in the DM mice subjected to the combined intervention strategy of PPE + BBPE. The histological findings indicated that the injury to the pancreatic islets in DM mice was also ameliorated following treatment. In conclusion, PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage; this finding may be useful in the prevention and treatment of DM.

By examining the compressive and flexural strength of composite and using scanning electron microscopy (SEM), we analyzed the influence of sodium hydroxide on the properties of FGD gypsum and slag composite materials and discussed the influence of sodium hydroxide on the setting time and mechanical strength of the composite materials and presented the action mechanism of sodium hydroxide as a stimulator. The results show that when the content of sodium hydroxide was percent of 0.25, the maximal strength of FGD gypsum-slag composite materials was reached.

When larger scale of small hydropower and wind power exist in power system, the traditional reserve capacity algorithm is no longer applicable at the same time of reducing the carbon emission. Aiming at the volatility and non-regulatory of small hydropower and wind power, considering the forecast error of small hydropower, wind power and load,the unit outage rate and other factors, combined with the actual operation parameters of one regional power system in Southwest of China, the wind-hydro – thermal power coordinated operation of multiple objective function optimization calculation model of reserve capacity is established. Using the weighted coefficient method of unified objective method, it transforms the multi-objective optimization problem into a single objective optimization one. Applying the exterior penalty function method, the constrained optimization problem is changed into a non-constrained optimization one. The improved particle swarm optimization algorithm is got by introducing the particle concentration cognition into traditional particle swarm optimization algorithm. The simulation results verify the validity of the model. To Compare them under different strategies, this method can get less fuel expenses of thermal power units in the case of lower loss of load probability (LOLP).With the small hydropower and wind power output size to optimize the spinning reserve capacity. The model and the algorithm are helpful for drawing up optimization strategies of the reserve capacity in those regions in which larger scale small hydropower and wind power exists.

As the development of the slurry pipeline transportation system complexity and intelligent,it is more difficult to establish the reliability of the system.This pape take advantage of the descriptions of dynamic systems of stochastic failure petri net,applying in the field of slurry pipeline transport system reliability analysis.At same time,with the combination of Markov theory, it established the model of the hydraulic system reliability analysis.The feasibility and availability of the method is proved through an example of hydraulic system of slurry pipeline transportation.

This paper begins with analyzing the hazard of system harmonics and proposing the effectiveness of active power filter (APF) in harmonic wave inhibition. Against the background of single-phase parallel type of APF, its working principle is introduced and its mathematical model is built. Next, analyzed in details is the single-phase parallel type of APF double loop control system based on outer voltage loop and inner current loop, with the specific design procedure of PI control parameters of outer voltage loop and inner current loop presented. Finally, through MATLAB simulation, the designed system control parameters undergo verification. The simulation result indicates such single-phase parallel type of APF based on the double loop PI controller with outer voltage loop and inner current loop can ensure stability of the DC bus voltage and make effective compensation for harmonics over the mid-and low-frequency bands.

In order to solve the difficult problem in lung CT image segmentation, the segmentation method based on Mixture Active Contour Model is proposed and the learning algorithm is presented. It gets the prior information of lung CT image segmentation through Gaussian Mixture Model, couples the penalty term and edge detection of the level set function. Experimental results illustrate the effectiveness of the method based on MACM in solving lung CT image segmentation.

Theresistance of slurry pipelinetransportation has greatly impact on slurry transportation system. In order toimprove transportation efficiency,energy utilization rate,taking theappropriate drag reduction technology has a very important significance.Thispaper presents drag reduction technologies for slurry transportationapplications,including micro-bubble drag reduction technology and vibrationdrag reduction technology.

It is very important to recycle and deal with them effectively for environment protection resources saving. In this paper, on the basis of relevant knowledge of classified recycling, we combine the situation of our surveying actually, establish electronic information platform which is suitable waste electronics. More important being, we design a recovery bins can be classified recycling battery. What’s more, according to the waste electronics recycling system, we put forward to increase the recovery rate and the better classified recycling.

In view of the fact that the complex control of car moving device, its small application range, the difficulty to reach the accurate location of vehicles and so on, therefor a new design and research for a car moving device of remote control is proposed; The Mecanum wheel is chosen to achieve the omnidirectional movement, so that the vehicle can reach the predetermined position quickly. The electro-hydraulic push rod is used to realize the automatic lifting ,and it is also convenient and efficient; In addition, AT89C52 microcontroller which cost less but can meet the requirements realize the control.

This dual-ducted SUAV is a nonlinear and strong coupling of multiple-input and multiple-output system, and particularly between the pitch and roll channels channel coupling is strong, in order to implement effective control, it must be decoupled. The traditional methods are difficult to achieve effective control of the strong coupling of multivariable systems. Neural network which has a strong learning ability, is able to learn from the sample and can adapt to changing learning condition. Thus, the neural network can be used to simulate the learning process of operator, and operating characteristics information of objects can be excavated from the measured data, and accordingly change the parameters of the controller and decoupling network. This paper presents a attitude control algorithm of the dual-ducted SUAV which combine ADRC algorithms with neural network decoupling control algorithm, to design a SUAV decoupling controller. The simulation results showed that the attitude control channels between the pitch and roll were independently of each other, indicating a good solution to decouple the coupling between the pitch and roll channels based on neural network algorithm.

This dual-ducted SUAV is a nonlinear and strong coupling of multiple-input and multiple-output system, and particularly between the pitch and roll channels channel coupling is strong, in order to implement effective control, it must be decoupled. The traditional methods are difficult to achieve effective control of the strong coupling of multivariable systems. For the SUAV model of nonlinear coupling characteristics, based on the establishment of the UAV attitude model, this paper designed an attitude ADRC decoupling controller. The simulation showed this ADRC decoupling controller had strong robustness and immunity, and solved the channels coupling between the pitch and roll.

Based on the sub-mini dual ducted UAV dynamics analysis of Newton, and according to the characteristics of the hovering and variable posture mechanism, this paper combined methods of mechanism analysis with system identification to get the attitude model of under actuated sub-mini dual ducted UAV, which contained input variable, output variable and some unknown parameters. Then the subspace method used the real flying data to identify above the attitude model. Finally，the correctness of the identification model was verified.

Recently, the UAV has become the research focus at home and abroad. this paper puts forward a unconventional type: double ducted tilting Subminiature UAV system (SUAV) , and carries out the research of the control system for this SUAV. Since SUAV flight attitude control process has strong time-varying characteristics, and there are random disturbances, the conventional control methods with unchanged parameters are often unworkable. An on-line adaptive ADRC control system is designed in this paper. An on-line adaptive ADRC system implements a simultaneous on-line tuning of ADRC rules and output scale of ADRC control system. The flight experiment showed that the proposed adaptive ADRC system provides quicker response, smaller overshoot, higher precision, robustness and adaptive ability. It satisfies the needs of autonomous flight.

Since Small Unmanned Helicopter flight attitude control process has strong time-varying characteristics, and there are random disturbances, the conventional control methods with unchanged parameters are often unworkable. An on-line adaptive ADRC control system is designed in this paper. An on-line adaptive ADRC system implements a simultaneous on-line tuning of ADRC rules and output scale of ADRC control system. The flight experiment showed that the proposed adaptive ADRC system provides quicker response, smaller overshoot, higher precision, robustness and adaptive ability. It satisfies the needs of autonomous flight.

In this work, a general expression of the thermo-acoustic (TA) emission from nanocrystalline porous silicon (nc-PS) is derived by using a fully thermally-mechanically coupled multilayer TA model. This expression takes thermal, mechanical, and geometry properties of every layer in a multilayer structure, as well as the thermal contact resistances between layers into consideration and hence agrees well with the experimental results. Therefore, many fundamental problems in thermally induced ultrasonic emission from nanoporous silicon can be studied.

In an attempt to investigate the formation rule and corrosion resistance of the plasma electrolytic oxidation (PEO) coating on crevice surface of AZ31 magnesium alloy, the crevice coatings were fabricated on the samples of irregular shapes with different values of crevice width. The value of crevice width was varied from 200 to 350 μm for investigating the effect of crevice width on the surface and cross-sectional morphology, phase composition, corrosion resistance of crevice coatings. The results indicated that the crevice coating differs markedly in morphology and corrosion resistance when the value of crevice width reaches 350 μm, in spite of all coated samples have similar phase compositions. The effect of current density and ultrasound treatment on crevice coatings thickness were also studied systematically. Studies have shown that the increase of current density and the introduction of ultrasound treatment are both favorable for the crevice coatings.

We review the sound attenuation in fluid due to the thermal diffusion and viscous dissipation and derive the formula of the sound attenuation coefficient in fluid by solving a fully thermally–mechanically coupled equation set. Problem occurring in Stokes–Kirchhoff relation, the well-known and widely used classical formula for sound attenuation coefficient, is therefore found and pointed out. The reason for its generation is analyzed and verified. An improved formula to replace Stokes–Kirchhoff relation is suggested and the typical case for the error in calculating sound pressure level (SPL) of attenuated sound wave in fluid between the two formulas is also given.

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism affects postnatal behaviors and is associated with a variety of neuropsychiatric disorders. However, the mechanisms underlying the BDNFMet variant induced dysfunctions of the central nervous system remain obscure. In order to identify the candidate genes and pathways responsible for the dysfunctions associated with this BDNF variation, we analyzed the expression of genes in the hippocampus, prefrontal cortex, and amygdala of the BDNFMet variant mice in comparison with the wild-type mice using Illumina bead microarray. Transcriptome profiling analysis revealed region-distinctive and gene-dose dependent changes of gene expression associated with the BDNFMet variant. BDNFMet variant mice exhibited altered expression of genes associated with translational machinery, neuronal plasticity and mitochondrial function based on the gene ontology (GO) annotation. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the chemokine, cell adhesion, ubiquitin-proteosome and wnt signaling pathways were altered in the BDNFMet variant mice brain. Finally, the CX3CL1/CX3CR1 signaling was identified to be impaired in the hippocampus and microinjection of CX3CL1 into the hippocampus could rescue the hippocampal dependent memory deficits in BDNFMet/Met mice, indicating that CX3CL1 may be an effective treatment option for memory disorders in humans with this genetic BDNF variation. These findings will help us further understanding the molecular mechanisms involved in the BDNFMet associated behavior and neuroanatomy alternations. © 2013 Wiley Periodicals, Inc.

Chaos is extremely sensitive to initial conditions, which makes the system with even smaller initial amount of changes can eventually evolve into a very different result. In an indirect field-oriented control of induction motor drive when estimated errors exist, within a certain range of parameters the system may evolve into chaotic motion through period-doubling bifurcation. In this paper an adaptive controller for synchronizing two indirect field-oriented induction motor drives under chaotic state is presented. Simulation results show that with the state-error feedback controller, synchronous state may be achieved rapidly and robustly.

A period-doubling bifurcation may occur when the estimation error of the rotor time constant exists in an indirect field-oriented control (IFOC) of induction motor drives. Then chaos oscillations appear under some parameter values which are usually tested by the Largest Lyapunov exponents. In this paper, we apply the modified 0-1 method to detect chaos phenomenon instead, and design a controller to suppress chaos in the IFOC system. Simulation results indicate that the proper parameter region of the controller can be obtained with this method, and with the adaptive controller the system can quit from the chaotic state into the stable state effectively and robustly. The 0-1 method identifies chaotic behaviors directly through the time series without constructing phase space. Therefore, the proposed method is not affected by the complexity of the system and is not sensitive to noises.

Objective To compare the biomechanical properties of two lag screws proximal femoral nail(PFN) when they are placed in different points of the neck of femur in the treatment of intertrochanteric fracture of femur. Method Three pairs of fresh femora of adults aging from 55 to 65 are taken. They are made into AO type A1.1 intertrochanteric fracture. Fracture specimens are fixed by PFN. The mechanical testing machine loads the fracture model at a speed of 0.5mm/s. The stress distribution of the fracture broken ends, the opening angle of the fracture broken ends, and the relationship between load and displacement are recorded respectively. Result The stress change of the group inferior of the small trochanter is smaller than that of the group superior. The opening angle of the fracture of the group inferior is smaller than that of the group superior. The displacement of the top of the femoral head of the group inferior is smaller than that of the group superior. Conclusion The performance of the group inferior is better than that of the group superior. Thus it can be concluded that when two lag screws of PFN were placed in the middle and below 1/3 part of femoral neck, the biomechanical properties are better, the structure is relatively more stable, and the stress bearing is more reasonable.

Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidney, but the efficacy of current strategies available for the prevention of DN remains unsatisfactory. The purpose of this study was to assess whether sitagliptin (SIT) has therapeutic potential for prevention of DN and to investigate its possible mechanism. The effects of SIT on DN were investigated in rats with type 2 diabetes mellitus (T2DM) and rat mesangial cells (MCs) induced by high glucose. T2DM rats were administered at a dose of 10 mg/kg SIT. The kidney index, 24 h urinary protein, blood urea nitrogen (BUN), serum creatinine (Cr), accumulation of glycogen and collagens were investigated by different methods. MCs were administered with SIT at doses of 0.1, 1 and 10 µmol/ml. The possible mechanism of SIT on protection of diabetic kidney injury was examined by expression of transforming growth factor-β1 (TGF-β1)/Smad pathway. The results showed that the SIT-treated diabetic rats significantly reduced diabetic kidney injury by inhibiting the kidney index and attenuating 24 h urinary protein, reducing BUN and serum creatinine, inhibiting progressive renal fibrosis and increassing extracellular matrix including collagen IV and fibronectin. Further studies showed that inhibition of renal fibrosis in SIT-treated diabetic rats and MCs were associated with rebalancing of TGF-β1/Smad pathway. Sitagliptin may be a potent agent for preventing the progression of DN through inhabiting TGF-β1/Smad-mediated renal fibrosis.

Because the structure of power system is getting larger and more complex, the configuration of PMU become a more complicated problems. Some algorithms are used to optimize the configuration schemes and achieves anticipated goals, however some of them can not improve the measurement accuracy and increase the computational efficiency at the same time. In order to enhance the precision of state estimation and the efficiency of optimal configuration, this paper models genetic algorithm into the MapReduce model, so the MapReduce genetic algorithm(MRGA) possesses some parallel computing performance, such as scalability, better fitness convergence and so on. MRGA is implemented on computing clusters of Hadoop to search the optimal configuration of PMU. Meanwhile, this feasibility and the computing performance of MRGA is verified by IEEE14-node system, IEEE118-node system, and Wp2383-node system. This method has significant advantages in the installed PMU number, the diversity of solution, the astringency and the practicability.

// Jian-Ping Li 1, 2, * , Zhi-Jun Huang 3, 4, * , Xing-Sheng Lu 5, * , Yi-Chan Zhou 1 , Yun Shao 1 , Xiao-Pu He 1 , Su-Rong Chen 2 , Dong-Dong Wang 2 , Li-Sen Qin 6 , Wei-Hao Sun 1 1 Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China 2 Department of Oncology, Yancheng Fist People’s Hospital, Yancheng, China 3 Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China 4 Department of Surgery, Yancheng Fist People’s Hospital, Yancheng, China 5 Department of Hepatobiliary Surgery, Suzhou Municipal Hospital, Suzhou, China 6 Department of Neurosurgery, Yancheng Pavilion Lake District People’s Hospital, Yancheng, China * Co-first authors Correspondence to: Wei-Hao Sun, email: swh@njmu.edu.cn , weihaosun@hotmail.com Keywords: colorectal cancer (CRC), PKC412, AKT, Bcl-2, receptor tyrosine kinases Received: July 29, 2016 Accepted: September 29, 2016 Published: October 21, 2016 ABSTRACT The potential effect of PKC412, a small molecular multi-kinase inhibitor, in colorectal cancer (CRC) cells was evaluated here. We showed that PKC412 was cytotoxic and anti-proliferative against CRC cell lines (HT-29, HCT-116, HT-15 and DLD-1) and primary CRC cells. PKC412 provoked caspase-dependent apoptotic death, and induced G2-M arrest in the CRC cells. AKT activation was inhibited by PKC412 in CRC cells. Reversely, expression of constitutively-active AKT1 (CA-AKT1) decreased the PKC412’s cytotoxicity against HT-29 cells. We propose that Bcl-2 could be a primary resistance factor of PKC412. ABT-737, a Bcl-2 inhibitor, or Bcl-2 siRNA knockdown, dramatically potentiated PKC412’s lethality against CRC cells. Forced Bcl-2 over-expression, on the other hand, attenuated PKC412’s cytotoxicity. Significantly, PKC412 oral administration suppressed AKT activation and inhibited HT-29 tumor growth in nude mice. Mice survival was also improved with PKC412 administration. These results indicate that PKC412 may have potential value for CRC treatment.

The highly pathogenic avian influenza (HPAI) H5N1 virus has caused several outbreaks in domestic poultry. Despite great efforts to control the spread of this virus, it continues to evolve and poses a substantial threat to public health because of a high mortality rate. In this study, we sequenced whole genomes of eight H5N1 avian influenza viruses isolated from domestic poultry in eastern China and compared them with those of typical influenza virus strains. Phylogenetic analyses showed that all eight genomes belonged to clade 2.3.2.1 and clade 7.2, the two main circulating clades in China. Viruses that clustered in clade 2.3.2.1 shared a high degree of homology with H5N1 isolates located in eastern Asian. Isolates that clustered in clade 7.2 were found to circulate throughout China, with an east-to-west density gradient. Pathogenicity studies in mice showed that these isolates replicate in the lungs, and clade 2.3.2.1 viruses exhibit a notably higher degree of virulence compared to clade 7.2 viruses. Our results contribute to the elucidation of the biological characterization and pathogenicity of HPAI H5N1 viruses.