101. Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type
- Author
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Elena Estrada, Pamela Sklar, Michele T. Pato, Carlos N. Pato, Jeffrey Tran, Donald M. Hilty, Jordan W. Smoller, and Sarah M. Hartz
- Subjects
Adult ,Male ,medicine.medical_specialty ,Psychosis ,Bipolar Disorder ,Population ,Schizoaffective disorder ,Logistic regression ,Article ,Nicotine ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Prevalence of mental disorders ,Internal medicine ,mental disorders ,medicine ,Humans ,Bipolar disorder ,education ,Genetics (clinical) ,education.field_of_study ,business.industry ,Tobacco Use Disorder ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Logistic Models ,Cohort ,Female ,sense organs ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N = 610), Bipolar disorder with psychosis (N = 1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N = 10065) using logistic regression. Among smokers (N = 6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR = 2.5; P
- Published
- 2015
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