Search

In the context of increasing British discomfort with the cult of sensibility in the 1790s, medical writers redefined the profile of the melancholic as a highly rational, rather than emotional, [...]

Evaluation of Fishman's exchange framework of financial organizations in remarriage reveals that remarried couples prefer pooling of financial resources but organize their finances depending on family requirements and own preferences. However, remarried couples prefer to choose an appropriate financial system for their specific needs, as financial pooling is not applicable to all remarried couples. Pooling of financial resources is a positive indicator of emotional bonding between the remarried couples.

Abstract Background Control of skeletal muscle mass and force production is a complex physiological process involving numerous regulatory systems. Agents that increase skeletal muscle cAMP levels have been shown to modulate skeletal muscle mass and force production. The dopamine 1 receptor and its closely related homolog, the dopamine 5 receptor, are G-protein coupled receptors that are expressed in skeletal muscle and increase cAMP levels when activated. Thus we hypothesize that activation of the dopamine 1 and/or 5 receptor will increase skeletal muscle cAMP levels thereby modulating skeletal muscle mass and force production. Methods We treated isolated mouse tibialis anterior (TA) and medial gastrocnemius (MG) muscles in tissue bath with the selective dopamine 1 receptor and dopamine 5 receptor agonist SKF 81297 to determine if activation of skeletal muscle dopamine 1 and dopamine 5 receptors will increase cAMP. We dosed wild-type mice, dopamine 1 receptor knockout mice and dopamine 5 receptor knockout mice undergoing casting-induced disuse atrophy with SKF 81297 to determine if activation of the dopamine 1 and dopamine 5 receptors results in hypertrophy of non-atrophying skeletal muscle and preservation of atrophying skeletal muscle mass and force production. Results In tissue bath, isolated mouse TA and MG muscles responded to SKF 81297 treatment with increased cAMP levels. Treating wild-type mice with SKF 81297 reduced casting-induced TA and MG muscle mass loss in addition to increasing the mass of non-atrophying TA and MG muscles. In dopamine 1 receptor knockout mice, extensor digitorum longus (EDL) and soleus muscle mass and force was not preserved during casting with SKF 81297 treatment, in contrast to significant preservation of casted wild-type mouse EDL and soleus mass and EDL force with SKF 81297 treatment. Dosing dopamine 5 receptor knockout mice with SKF 81297 did not significantly preserve EDL and soleus muscle mass and force although wild-type mouse EDL mass and force was significantly preserved SKF 81297 treatment. Conclusions These data demonstrate for the first time that treatment with a dopamine 1/5 receptor agonist results in (1) significant preservation of EDL, TA, MG and soleus muscle mass and EDL muscle force production during periods of atrophy and (2) hypertrophy of TA and MG muscle. These effects appear to be mainly mediated by both the dopamine 1 and dopamine 5 receptors.

Abstract Background Muscle weakness is associated with a variety of chronic disorders such as emphysema (EMP) and congestive heart failure (CHF) as well as aging. Therapies to treat muscle weakness associated with chronic disease or aging are lacking. Corticotrophin releasing factor 2 receptor (CRF2R) agonists have been shown to maintain skeletal muscle mass and force production in a variety of acute conditions that lead to skeletal muscle wasting. Hypothesis We hypothesize that treating animals with a CRF2R agonist will maintain skeletal muscle mass and force production in animals with chronic disease and in aged animals. Methods We utilized animal models of aging, CHF and EMP to evaluate the potential of CRF2R agonist treatment to maintain skeletal muscle mass and force production in aged animals and animals with CHF and EMP. Results In aged rats, we demonstrate that treatment with a CRF2R agonist for up to 3 months results in greater extensor digitorum longus (EDL) force production, EDL mass, soleus mass and soleus force production compared to age matched untreated animals. In the hamster EMP model, we demonstrate that treatment with a CRF2R agonist for up to 5 months results in greater EDL force production in EMP hamsters when compared to vehicle treated EMP hamsters and greater EDL mass and force in normal hamsters when compared to vehicle treated normal hamsters. In the rat CHF model, we demonstrate that treatment with a CRF2R agonist for up to 3 months results in greater EDL and soleus muscle mass and force production in CHF rats and normal rats when compared to the corresponding vehicle treated animals. Conclusions These data demonstrate that the underlying physiological conditions associated with chronic diseases such as CHF and emphysema in addition to aging do not reduce the potential of CRF2R agonists to maintain skeletal muscle mass and force production.

Abstract Background Duchenne muscular dystrophy results from mutation of the dystrophin gene, causing skeletal and cardiac muscle loss of function. The mdx mouse model of Duchenne muscular dystrophy is widely utilized to evaluate the potential of therapeutic regimens to modulate the loss of skeletal muscle function associated with dystrophin mutation. Importantly, progressive loss of diaphragm function is the most consistent striated muscle effect observed in the mdx mouse model, which is the same as in patients suffering from Duchenne muscular dystrophy. Methods Using the mdx mouse model, we have evaluated the effect that corticotrophin releasing factor 2 receptor (CRF2R) agonist treatment has on diaphragm function, morphology and gene expression. Results We have observed that treatment with the potent CRF2R-selective agonist PG-873637 prevents the progressive loss of diaphragm specific force observed during aging of mdx mice. In addition, the combination of PG-873637 with glucocorticoids not only prevents the loss of diaphragm specific force over time, but also results in recovery of specific force. Pathological analysis of CRF2R agonist-treated diaphragm muscle demonstrates that treatment reduces fibrosis, immune cell infiltration, and muscle architectural disruption. Gene expression analysis of CRF2R-treated diaphragm muscle showed multiple gene expression changes including globally decreased immune cell-related gene expression, decreased extracellular matrix gene expression, increased metabolism-related gene expression, and, surprisingly, modulation of circadian rhythm gene expression. Conclusion Together, these data demonstrate that CRF2R activation can prevent the progressive degeneration of diaphragm muscle associated with dystrophin gene mutation.

This article reviews remarriage trends and the social, financial, and developmental challenges facing remarried families. The article suggests ways home economists can apply their skills to help strengthen these families through research, education, and service. (CT)

Reviews several child-related consumer protection issues subject to industry short-sightedness and regulatory manipulation. Indicates that although it may be unrealistic to believe that child-related consumer protection should receive priority, children do merit special consideration as consumers. (JOW)

Examines the Social Security benefit inequities between male and female workers and between one- and two-earner families and traces the cause of such disparities. Discusses the evolution of today's Social Security System and presents two proposals for a possible reform of the system. (CT)

Social workers are provided with better understanding of the challenges and needs of rural, low-income families as a basis for interventions and support. It was seen that at a certain point, most mothers had incomes that was less than 130% of poverty level and was not adequate to support families financially.

Investigates the relative value of keyword searching versus authority control on an online catalog. Need for keywords in nonpreferred headings to be truncated to match terms in bibliographic records; Usefulness of cataloging fields in retrieving cataloging records using nonpreferred terms as access points; Overview of coding alternate forms.

After 20 years of service in the British Army in India, Sir Lionel Smith, KCB (1777–1842) was appointed Governor of Barbados and Governor General of the Windward Islands in order to enact the abolition of slavery in the West Indies. During his three-year tenure, Smith relied on two major rhetorical strategies to advocate for the rights of free Afro-Barbadians and enslaved/apprenticed people. In general, Smith invoked utilitarian arguments, derived from his experience in India, when presenting free Afro-Barbadian men’s demands for equal voting rights, but also resorted to a more humanitarian mode, characteristic of abolitionist rhetoric, when arguing for judicial system reforms that would benefit enslaved and apprenticed people. This essay analyzes the ways in which Smith’s positions resonated with or diverged from those of the Colonial Office, and from those of Barbadian people of color, based on correspondence with the Colonial Office, including two documents written by free men of color, and one by an apprentice. Although Smith was eager to apply the British colonial policy he experienced in India to the impending social changes in the West Indies, the Colonial Office was not as willing to draw these parallels, responding more enthusiastically to Smith’s use of abolitionist rhetoric. [ABSTRACT FROM AUTHOR]