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735 results on '"Dignat-George, F."'

101. Un biomarqueur de la vasculopathie de l’adulte drépanocytaire ?

Author

Masson, E., primary, Lacroix, R., additional, Sautereau, N., additional, Eldin, C., additional, Ebbo, M., additional, Brun, M., additional, Arnaud, L., additional, Thuret, I., additional, Schleinitz, N., additional, Harle, J.-R., additional, Dignat George, F., additional, and Bernit, E., additional

Published
2014
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106. Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome : Relationship with oxidative stress

Author

Helal, O., Defoort, C., Robert, S., Marin, C., Lesavre, N., Lopez-Miranda, J., Risérus, Ulf, Basu, Samur, Lovegrove, J., McMonagle, J., Roche, H. M., Dignat-George, F., Lairon, D., Helal, O., Defoort, C., Robert, S., Marin, C., Lesavre, N., Lopez-Miranda, J., Risérus, Ulf, Basu, Samur, Lovegrove, J., McMonagle, J., Roche, H. M., Dignat-George, F., and Lairon, D.

Abstract

Background and aims: The Metabolic Syndrome (MetS) is associated with increased cardiovascular risk. Circulating microparticles (MP) are involved in the pathogenesis of atherothrombotic disorders and are raised in individual with CVD. We measured their level and cellular origin in subjects with MetS and analyzed their associations with 1/anthropometric and biological parameters of MetS, 2/inflammation and oxidative stress markers. Methods and results: Eighty-eight subjects with the MetS according to the NCEP-ATPIII definition were enrolled in a bicentric study and compared to 27 healthy controls. AnnexinV-positive MP (TMP), MP derived from platelets (PMP), erythrocytes (ErMP), endothelial cells (EMP), leukocytes (LMP) and granulocytes (PNMP) were determined by flow cytometry. MetS subjects had significantly higher counts/mu l of TMP (730.6 +/- 49.7 vs 352.8 +/- 35.6), PMP (416.0 +/- 43.8 vs 250.5 +/- 23.5), ErMP (243.8 +/- 22.1 vs 73.6 +/- 19.6) and EMP (7.8 +/- 0.8 vs 4.0 +/- 1.0) compared with controls. LMP and PNMP were not statistically different between groups. Multivariate analysis demonstrated that each criterion for the MetS influenced the number of TMP. Waist girth was a significant determinant of PMP and EMP level and blood pressure was correlated with EMP level. Glycemia positively correlated with PMP level whereas dyslipidemia influenced EMP and ErMP levels. Interestingly, the oxidative stress markers, plasma glutathione peroxy-dase and urinary 8-iso-prostaglandin F(2) alpha, independently influenced TMP and PMP levels whereas inflammatory markers did not, irrespective of MP type. Conclusion: Increased levels of TMP, PMP, ErMP and EMP are associated with individual metabolic abnormalities of MetS and oxidative stress. Whether MP assessment may represent a marker for risk stratification or a target for pharmacological intervention deserves further investigation.

Published
2011
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107. Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1alpha.

Author

Berda-Haddad, Y., Robert, S., Salers, P., Zekraoui, L., Farnarier, C., Dinarello, C.A., Dignat-George, F., Kaplanski, G., Berda-Haddad, Y., Robert, S., Salers, P., Zekraoui, L., Farnarier, C., Dinarello, C.A., Dignat-George, F., and Kaplanski, G.

Abstract

Item does not contain fulltext, Sterile inflammation resulting from cell death is due to the release of cell contents normally inactive and sequestered within the cell; fragments of cell membranes from dying cells also contribute to sterile inflammation. Endothelial cells undergoing stress-induced apoptosis release membrane microparticles, which become vehicles for proinflammatory signals. Here, we show that stress-activated endothelial cells release two distinct populations of particles: One population consists of membrane microparticles (<1 mum, annexin V positive without DNA and no histones) and another larger (1-3 mum) apoptotic body-like particles containing nuclear fragments and histones, representing apoptotic bodies. Contrary to present concepts, endothelial microparticles do not contain IL-1alpha and do not induce neutrophilic chemokines in vitro. In contrast, the large apoptotic bodies contain the full-length IL-1alpha precursor and the processed mature form. In vitro, these apoptotic bodies induce monocyte chemotactic protein-1 and IL-8 chemokine secretion in an IL-1alpha-dependent but IL-1beta-independent fashion. Injection of these apoptotic bodies into the peritoneal cavity of mice induces elevated serum neutrophil-inducing chemokines, which was prevented by cotreatment with the IL-1 receptor antagonist. Consistently, injection of these large apoptotic bodies into the peritoneal cavity induced a neutrophilic infiltration that was prevented by IL-1 blockade. Although apoptosis is ordinarily considered noninflammatory, these data demonstrate that nonphagocytosed endothelial apoptotic bodies are inflammatory, providing a vehicle for IL-1alpha and, therefore, constitute a unique mechanism for sterile inflammation.

Published
2011

108. Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop.

Author

UCL - (MGD) Laboratoire de biologie clinique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Lacroix, R, Robert, S, Poncelet, P, Kasthuri, R S, Key, N S, Dignat-George, F, Mullier, François, UCL - (MGD) Laboratoire de biologie clinique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Lacroix, R, Robert, S, Poncelet, P, Kasthuri, R S, Key, N S, Dignat-George, F, and Mullier, François

Published
2010

109. Le taux plasmatique de microparticules leucocytaires dépiste les plaques instables des patients asymptomatiques porteurs d’une sténose carotidienne serrée

Author

Sarlon-Bartoli, G., primary, Bennis, Y., additional, Lacroix, R., additional, Piercecchi-Marti, M., additional, Bartoli, M., additional, Arnaud, L., additional, Mancini, J., additional, Boudes, A., additional, Sarlon, E., additional, Leroyer, A., additional, Squarcioni, C., additional, Magnan, P., additional, Dignat-George, F., additional, and Sabatier, F., additional

Published
2013
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120. 245 Urodynamic and histologic effects of autologous adipose derived stem cells endoscopically injected in a porcin model of intrinsic sphincter deficiency

Author

Boissier, R., primary, Giraudo, L., additional, Veran, J., additional, Magalon, J., additional, Sabatier, F., additional, Giusiano, S., additional, Garcia, S., additional, Arnaud, L., additional, Dignat-George, F., additional, Magalon, G., additional, Lechevallier, E., additional, Berdah, S., additional, and Karsenty, G., additional

Published
2013
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121. Standardized counting of circulating platelet microparticles using currently available flow cytometers and scatter-based triggering: Forward or side scatter?

Author

Poncelet, P., Robert, S., Bouriche, T., Bez, J., Lacroix, R., and Dignat‐George, F.

Abstract

Clinical determination of MP counts using flow cytometry has not been fully accepted yet due to the lack of standardization protocols. In the past 5 years, we have proposed two versions of a method with reproducible PMP counts in plasma samples. Both methods use forward scatter (FSC)-based threshold set with reference beads of appropriate sizes; first using 0.5 µm beads and later with 0.3 µm beads. Both systems provide reproducible PMP counts. However, this technique works only with some of currently used commercial flow cytometers. Instruments with limited resolution or generating heterogeneous FSC signals are excluded. Such performances are incompatible with the required interinstrument standardization. Here we show that (i) flow cytometers with sub-optimal FSC capabilities generally have higher SSC resolution and background rejection capacity, and (ii) that the same biological entities, 'dim and bright PMP,' both can be counted using alternative strategies, either as previously described, based on FSC measurements, or as presented here, based on SSC detection. The critical element in the standardization protocol is the use of different sizes of reference beads. This study was designed to permit simultaneous access to both FSC- and SSC-optimized platforms. A new range of about 0.17-0.6 µm eq. (µm-equivalents) is proposed for an alternative SSC-based MP gate generating the same PMP counts as those obtained in the previously proposed 0.3-1 µm eq. FSC-based MP gate. The two equivalent standardization options reconcile intrinsically different scattering behaviors between SSC- and FCS - triggered instruments and open the opportunity for multicenter studies in the future. © 2015 International Society for Advancement of Cytometry [ABSTRACT FROM AUTHOR]

Published
2016
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123. Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

Author

Lacroix, R., primary, Plawinski, L., additional, Robert, S., additional, Doeuvre, L., additional, Sabatier, F., additional, Martinez de Lizarrondo, S., additional, Mezzapesa, A., additional, Anfosso, F., additional, Leroyer, A. S., additional, Poullin, P., additional, Jourde, N., additional, Njock, M.-S., additional, Boulanger, C. M., additional, Angles-Cano, E., additional, and Dignat-George, F., additional

Published
2012
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124. Circulating Lipoprotein-associated Phospholipase A2 in High-grade Carotid Stenosis: A New Biomarker for Predicting Unstable Plaque

Author

Sarlon-Bartoli, G., primary, Boudes, A., additional, Buffat, C., additional, Bartoli, M.A., additional, Piercecchi-Marti, M.D., additional, Sarlon, E., additional, Arnaud, L., additional, Bennis, Y., additional, Thevenin, B., additional, Squarcioni, C., additional, Nicoli, F., additional, Dignat-George, F., additional, Sabatier, F., additional, and Magnan, P.E., additional

Published
2012
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128. Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: Relationship with oxidative stress

Author

Helal, O., primary, Defoort, C., additional, Robert, S., additional, Marin, C., additional, Lesavre, N., additional, Lopez-Miranda, J., additional, Risérus, U., additional, Basu, S., additional, Lovegrove, J., additional, McMonagle, J., additional, Roche, H.M., additional, Dignat-George, F., additional, and Lairon, D., additional

Published
2011
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129. Malnutrition & inflammation in CKD 1-5

Author

Gursu, M., primary, Aydin, Z., additional, Karadag, S., additional, Uzun, S., additional, Ogul, S., additional, Kiris, A., additional, Doventas, Y., additional, Koldas, M., additional, Ozturk, S., additional, Kazancioglu, R., additional, Mandreoli, M., additional, Bellasi, A., additional, Baldrati, L., additional, Corradini, M., additional, Rigotti, A., additional, Russo, G., additional, David, S., additional, Malmusi, G., additional, DiNicolo', P., additional, Orsi, C., additional, Zambianchi, L., additional, Caruso, F., additional, Poisetti, P., additional, Fabbri, A., additional, Santoro, A., additional, Barton Pai, A., additional, Grabe, D., additional, Eisele, G., additional, Hutchison, C. A., additional, Bevins, A., additional, Lukacik, P., additional, Hughes, R. G., additional, Pratt, G., additional, Viana, J. L., additional, Bishop, N. C., additional, Kosmadakis, G., additional, Bevington, A., additional, Clapp, E. L., additional, Feehally, J., additional, Smith, A. C., additional, Joki, N., additional, Hase, H., additional, Tanaka, Y., additional, Iwasaki, M., additional, Yamaka, T., additional, Shigematsu, T., additional, Dou, L., additional, Gondouin, B., additional, Cerini, C., additional, Duval-Sabatier, A., additional, Poitevin, S., additional, Dignat-George, F., additional, Burtey, S., additional, Brunet, P., additional, Carrasco, F., additional, Salvador, F., additional, Origaca, C., additional, Nogueira, E., additional, Silva, N., additional, Silva, A., additional, Sikole, A., additional, Trajceska, L., additional, Selim, G., additional, Gelev, S., additional, Dzekova, P., additional, Amitov, V., additional, Arsov, S., additional, Dalboni, M., additional, Cruz, E., additional, Manfredi, S., additional, Mouro, M., additional, Quinto, M., additional, Grabulosa, C., additional, Batista, M., additional, Cendoroglo, M., additional, Hirayama, A., additional, Matsui, H., additional, Nagano, Y., additional, Ueda, A., additional, Aoyagi, K., additional, Owada, S., additional, Schepers, E., additional, Barreto, D., additional, Liabeuf, S., additional, Glorieux, G., additional, Eloot, S., additional, Barreto, F., additional, Massy, Z., additional, Vanholder, R., additional, Secara, I. F., additional, Oleniuc, M., additional, Nistor, I., additional, Onofriescu, M., additional, Covic, A., additional, Aguerrevere, S., additional, Granada, M., additional, Bayes, B., additional, Pastor, M., additional, Sancho, A., additional, Bonal, J., additional, Canas, L., additional, Lauzurica, R., additional, Teixido, J., additional, Troya, M., additional, Romero, R., additional, Capitanini, A., additional, D'Alessandro, C., additional, Ferretti, V., additional, Petrone, I., additional, Pasquariello, G., additional, Cupisti, A., additional, Parastayeva, M. M., additional, Berseneva, O. N., additional, Kucher, A. G., additional, Ivanova, G. T., additional, Smirnov, A. V., additional, Kayukov, I. G., additional, Kayabasi, H., additional, Esmer, S., additional, Yilmaz, Z., additional, Kadiroglu, A. K., additional, Yilmaz, M. E., additional, Radic, J., additional, Kovacic, V., additional, Radic, M., additional, Ljutic, D., additional, Sain, M., additional, Karakan, S., additional, Sezer, S., additional, Tutal, E., additional, Ozdemir Acar, F. N., additional, Bi, G., additional, Xing, C., additional, Chen, R., additional, Romero-Garcia, A., additional, Jacobo-Arias, F., additional, Martin del Campo, F., additional, Gonzalez-Espinoza, L., additional, Pazarin, L., additional, Cueto-Manzano, A. M., additional, Panagoutsos, S., additional, Kriki, P., additional, Mourvati, E., additional, Tziakas, D., additional, Chalikias, G., additional, Stakos, D., additional, Apostolakis, S., additional, Tsigalou, C., additional, Gioka, T., additional, Konstantinides, S., additional, Vargemezis, V., additional, Nascimento, M., additional, Hayashi, S., additional, Seeberger, A., additional, Yamamoto, T., additional, Qureshi, A. R., additional, Lind, B., additional, Riella, M., additional, Brodin, L.-A., additional, Lindholm, B., additional, Meier, P., additional, Menne, J., additional, Kruger, K., additional, Mooren, F. C., additional, Weissmann, N., additional, Seimetz, M., additional, Haller, H., additional, Gusev, E., additional, Solomatina, L., additional, Zhuravleva, J., additional, Striker, G., additional, Uribarri, J., additional, Cai, W., additional, Goodman, S., additional, Pyzik, R., additional, Grosjean, F., additional, Vlassara, H., additional, So, A., additional, Gimona, A., additional, Kiechle, T., additional, Shpilsky, A., additional, and Schlesinger, N., additional

Published
2011
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134. Abstract 5013: Body Mass Index is the Main Determinant of High On-treatment Platelet Reactivity and of Failed Dose Adjustment According to Platelet Reactivity Monitoring

Author

Bonello, N, primary, Armero, S, additional, Paganelli, F, additional, Mancini, J, additional, Maillard, L, additional, de Labriolle, A, additional, Barragan, P, additional, Bonello, Caroline, additional, Dignat-George, F, additional, Camoin-Jau, L, additional, and Bonello, Laurent, additional

Published
2009
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137. E014 Generation de plasmine par les microparticules endotheliales : un nouveau mecanisme dans la regulation des activites proteolytiques de l’endothelium

Author

Lacroix, R., primary, Sabatier, F., additional, Mialhe, A., additional, Basire, A., additional, Pannell, R., additional, Borghi, H., additional, Robert, S., additional, Lamy, E., additional, Plawinski, L., additional, Camoin-Jau, L., additional, Gurewich, V., additional, Angles-Cano, E., additional, and Dignat-George, F., additional

Published
2009
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139. Influence des traitements hypocholestérolémiants sur la déplétion lymphocytaire B induite par rituximab dans le contexte des maladies auto-immunes

Author

Chiche, L., primary, Mancini, J., additional, Branger, S., additional, Bornet, C.-E., additional, Jean, R., additional, Mazodier, K., additional, Kaplanski, G., additional, Schleinitz, N., additional, Durand, J.-M., additional, Dignat-George, F., additional, Nicolino-Brunet, C., additional, and Harle, J.-R., additional

Published
2008
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